Affinage

RPLP1

Large ribosomal subunit protein P1 · UniProt P05386

Round 2 corrected
Length
114 aa
Mass
11.5 kDa
Annotated
2026-04-28
130 papers in source corpus 10 papers cited in narrative 10 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPLP1 is an acidic phosphoprotein of the 60S ribosomal subunit stalk that functions in translation elongation and selective translational regulation. It assembles specifically into the large ribosomal subunit via its conserved C-terminal domain shared with P0 and P2, forming a stalk complex analogous to bacterial L7/L12–L10 that coordinates elongation factor interactions (PMID:3323886, PMID:23636399). RPLP1 relieves ribosome pausing at mRNA sequences encoding multi-pass transmembrane domains, facilitating co-translational folding and protein stability, and is particularly critical for flavivirus polyprotein translation (PMID:32890404, PMID:27974556). Genetic ablation in mice does not impair global protein synthesis but selectively alters translation of cell cycle, stress-response, and protein-folding transcripts, causing CNS-specific progenitor cell death and perinatal lethality, while overexpression drives E2F1/cyclin E–dependent proliferation and cooperates with oncogenic Ras in cellular transformation (PMID:24959908, PMID:19233166).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 1987 High

    Identification of RPLP1 as a conserved acidic phosphoprotein of the 60S stalk resolved the molecular identity and subunit specificity of the mammalian L7/L12-analogous complex.

    Evidence cDNA cloning, in vitro translation, immunoprecipitation, and ribosome reconstitution assembly assay

    PMID:3323886

    Open questions at the time
    • No functional assay for translation activity
    • Stoichiometry of P1/P2 heterodimer on the stalk not determined
    • Phosphorylation site(s) not mapped
  2. 2009 Medium

    Demonstration that RPLP1 overexpression drives E2F1-dependent proliferation and cooperates with Ras for transformation established RPLP1 as an active proliferative driver, not merely a housekeeping ribosomal component.

    Evidence Retroviral screen in MEFs, E2F1 promoter-reporter assay, cyclin E western blot, soft-agar transformation assay with RasVal12

    PMID:19233166

    Open questions at the time
    • Mechanism linking RPLP1 to E2F1 promoter activation unknown
    • Whether this effect requires ribosomal incorporation or a ribosome-independent function is unresolved
    • No loss-of-function counterpart in this study
  3. 2013 High

    Cryo-EM visualization of the human ribosomal stalk placed RPLP1 architecturally, showing how the stalk co-evolved with metazoan rRNA to coordinate elongation factor binding.

    Evidence High-resolution cryo-EM of human and Drosophila 80S ribosomes with atomic model building

    PMID:23636399

    Open questions at the time
    • RPLP1 C-terminal domain largely unresolved due to flexibility
    • No direct visualization of RPLP1–elongation factor interface
    • Dynamic stalk conformations during translocation not captured
  4. 2014 High

    Mouse knockout revealed that RPLP1 is dispensable for bulk translation but essential for selective translational control of cell cycle and stress-response proteins, and required for CNS progenitor survival and brain development.

    Evidence Germline and CNS-conditional Rplp1 knockout mice; 2D-DIGE proteomics, immunohistochemistry, flow cytometry

    PMID:24959908

    Open questions at the time
    • Ribosome profiling not performed to identify direct translational targets
    • Mechanism of selective translation (mRNA features conferring RPLP1 dependence) unknown
    • Functional redundancy with RPLP2 not assessed in vivo
  5. 2017 High

    Identification of RPLP1/2 as essential host factors for flavivirus infection pinpointed their requirement at the viral translation step, linking the stalk's elongation function to a pathological context.

    Evidence Genome-scale RNAi screen, siRNA knockdown in A549 and HuH-7 cells, metabolic labeling, viral and transgene expression assays, in vivo mosquito experiments

    PMID:27974556

    Open questions at the time
    • Whether viral RNA features (e.g., structured UTRs) specifically require stalk activity not determined
    • Contribution of P1 vs P2 individually not separated
    • No structural data on stalk–viral polysome interaction
  6. 2020 High

    Ribosome profiling resolved the mechanism: RPLP1/2 relieve ribosome pausing at sequences encoding multi-pass transmembrane domains, linking stalk function to co-translational membrane protein folding and explaining the selective translational defects seen in knockouts.

    Evidence Ribo-seq in RPLP1/2-depleted cells, protein stability assays, bioinformatic analysis of TMD-containing transcripts

    PMID:32890404

    Open questions at the time
    • Direct biophysical mechanism by which the stalk facilitates TMD co-translational folding is unknown
    • Whether RPLP1 and RPLP2 are functionally redundant or contribute distinct activities to pause resolution is unclear
    • Extent of TMD-pausing phenotype in vivo (animal models) not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The biophysical mechanism by which the ribosomal stalk P1/P2 complex relieves elongation pausing at TMD-encoding sequences, and whether RPLP1 has ribosome-independent functions in proliferation signaling, remain unresolved.
  • No reconstituted system to test stalk-dependent pause resolution biochemically
  • RPLP1 vs RPLP2 functional specificity not dissected
  • Structural basis for selective mRNA dependence on stalk proteins unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0045182 translation regulator activity 2
Localization
GO:0005840 ribosome 3 GO:0005829 cytosol 2
Pathway
R-HSA-392499 Metabolism of proteins 4 R-HSA-1640170 Cell Cycle 2
Partners
RPLP0RPLP2
Complex memberships
60S ribosomal subunit stalk (P0-P1-P2 complex)80S ribosome

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1987 Human acidic ribosomal phosphoprotein P1 (RPLP1) was identified and its cDNA cloned. RPLP1 shares a nearly identical carboxy-terminal 17-amino-acid sequence (KEESEESD(D/E)DMGFGLFD-COOH) with P0 and P2, explaining their immunological cross-reactivity. In vitro synthesized RPLP1 assembled specifically into 60S but not 40S ribosomes and formed a complex analogous to bacterial L7/L12 and L10, indicating RPLP1 is part of the large ribosomal subunit stalk. cDNA cloning, in vitro transcription/translation, immunoprecipitation, ribosome assembly assay Molecular and cellular biology High 3323886
1995 Mammalian ribosomal protein RPLP1 (P1) was structurally characterized as an acidic phosphoprotein homologous to bacterial L7/L12; it is located in the 60S ribosomal subunit stalk and its mRNA carries a terminal oligopyrimidine (TOP) tract characteristic of ribosomal protein mRNAs, linking translational regulation to ribosome biogenesis. Amino acid sequencing, sequence comparison, structural analysis of ribosomal proteins Biochemistry and cell biology Medium 8722009
2007 The RPLP1 gene and protein are highly conserved across mammals (human, mouse, rat, bovine, porcine, and giant panda), with >88% amino acid sequence identity. The protein contains Casein kinase II phosphorylation sites and N-myristoylation sites. Recombinant His-tagged RPLP1 was expressed in E. coli as an ~18 kDa polypeptide consistent with the predicted molecular weight. RT-PCR cDNA cloning, sequence analysis, prokaryotic overexpression International journal of biological sciences Low 18071584
2009 Overexpression of Rplp1 in primary mouse embryonic fibroblasts (MEFs) bypassed replicative senescence, produced a two-fold increase in E2F1 promoter activity, and upregulated cyclin E. Co-expression of Rplp1 with mutant Ras (RasVal12) caused oncogenic transformation of NIH3T3 cells as demonstrated by soft-agar colony formation, establishing Rplp1 as a driver—not merely a consequence—of cell proliferation. Retroviral cDNA library screen, promoter-reporter assay, soft-agar transformation assay, western blot, MEF immortalization assay Experimental cell research Medium 19233166
2013 Cryo-EM structures of the human and Drosophila 80S ribosomes revealed the architectural position of ribosomal stalk proteins including RPLP1 within the large subunit, showing their co-evolution with metazoan-specific ribosomal RNA and their role in forming the stalk structure that coordinates translation elongation factor interactions. High-resolution cryo-electron microscopy, atomic model building Nature High 23636399
2014 Germline disruption of Rplp1 in mice caused body size reduction, male infertility, and high rates of early postnatal death, while CNS-specific deletion (Rplp1CNSΔ) resulted in perinatal lethality and brain atrophy with reduced neocortex, midbrain, and ganglionic eminence. Rplp1 knockout neocortex exhibited progenitor cell proliferation arrest and apoptosis with dysregulation of cyclin A, cyclin E, p21CIP1, p27KIP1, and p53. Deletion in primary MEFs caused proliferation arrest and premature senescence. Importantly, Rplp1 deletion did not alter global protein synthesis but changed expression of specific protein subsets involved in protein folding, unfolded protein response, and cell death, indicating a 'translational fine-tuning' role. Conditional and germline mouse knockout, immunohistochemistry, flow cytometry, western blot, 2D-DIGE proteomics, histology PloS one High 24959908
2015 Near-atomic resolution cryo-EM structure of the human 80S ribosome (average 3.6 Å, best 2.9 Å) was determined, providing atomic-level detail of the ribosomal stalk where RPLP1 resides, including visualization of rRNA entities, amino acid side chains, tRNA binding sites, and subunit interface remodeling during ribosomal rotation. Single-particle cryo-electron microscopy, atomic model building Nature High 25901680
2017 RPLP1 and RPLP2 (RPLP1/2) were identified as essential host factors for dengue virus (DENV), yellow fever virus (YFV), and Zika virus (ZIKV) infection. Knockdown of RPLP1/2 strongly reduced early DENV protein accumulation and reduced DENV structural proteins expressed from an exogenous transgene, indicating a requirement specifically at the translation step. While RPLP1/2 depletion caused only modest and cell-line-specific effects on global protein synthesis (increased in A549, decreased in HuH-7), it strongly impaired viral translation elongation through the viral open reading frame, consistent with their known role in orchestrating translation elongation via the ribosomal stalk. Genome-scale RNAi screen, siRNA knockdown, metabolic labeling, viral infection assay in two human cell lines and Aedes aegypti mosquitoes, transgene expression assay Journal of virology High 27974556
2020 RPLP1/2 relieve ribosome pausing within the dengue virus envelope protein coding sequence, specifically at sequences encoding the N-terminus of the envelope protein immediately downstream of two adjacent transmembrane domains (TMDs). Ribosome profiling of RPLP1/2-depleted cells showed increased ribosome pausing at this region and disproportionate effects on mRNAs encoding multiple TMDs, implying a general role for RPLP1/2 in facilitating elongation through multi-pass transmembrane protein-coding sequences, likely by improving co-translational folding efficiency and subsequent protein stability. siRNA knockdown, ribosome profiling (Ribo-seq), protein stability assays, bioinformatic analysis of TMD-containing mRNAs Nucleic acids research High 32890404
2020 CNN3 (calponin 3) promotes cervical cancer cell viability and motility partly through upregulation of RPLP1 mRNA expression, as demonstrated by RNA sequencing identifying RPLP1 as a downstream target of CNN3, and rescue experiments showing that RPLP1 overexpression partially reverses the phenotypes inhibited by CNN3 silencing, placing RPLP1 downstream of CNN3 in a pro-tumorigenic pathway. siRNA knockdown, RNA-seq, qRT-PCR, proliferation/migration/invasion assays, xenograft mouse model, rescue overexpression experiments Scientific reports Medium 32051425

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2861 17081983
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nature biotechnology 1336 16964243
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nature cell biology 490 21423176
2013 Structures of the human and Drosophila 80S ribosome. Nature 481 23636399
2006 Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature 480 16541025
2020 SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses. Cell 449 33080218
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2011 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nature immunology 405 21642987
2004 The molecular mechanics of eukaryotic translation. Annual review of biochemistry 396 15189156
2015 Structure of the human 80S ribosome. Nature 380 25901680
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
2002 The P1' specificity of tobacco etch virus protease. Biochemical and biophysical research communications 330 12074568
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2006 Phosphoproteome analysis of the human mitotic spindle. Proceedings of the National Academy of Sciences of the United States of America 281 16565220
2003 Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell 276 14567916
1987 Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. Molecular and cellular biology 275 3323886
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
1995 Structure and evolution of mammalian ribosomal proteins. Biochemistry and cell biology = Biochimie et biologie cellulaire 265 8722009
2011 A directed protein interaction network for investigating intracellular signal transduction. Science signaling 258 21900206
2005 Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. Nature methods 243 16094384
2004 Genome of bacteriophage P1. Journal of bacteriology 225 15489417
1991 Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution. The EMBO journal 178 1710977
1988 An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters. Cell 164 2904838
1996 The role of MCM/P1 proteins in the licensing of DNA replication. Trends in biochemical sciences 159 8882583
1999 P1 ParA interacts with the P1 partition complex at parS and an ATP-ADP switch controls ParA activities. The EMBO journal 142 10064607
1987 Cloning and sequence analysis of cytadhesin P1 gene from Mycoplasma pneumoniae. Infection and immunity 124 3119495
2011 Impact of ectoenzymes on p2 and p1 receptor signaling. Advances in pharmacology (San Diego, Calif.) 113 21586362
1999 Intracellular localization of P1 ParB protein depends on ParA and parS. Proceedings of the National Academy of Sciences of the United States of America 99 10611311
1998 Corepression of the P1 addiction operon by Phd and Doc. Journal of bacteriology 93 9829946
1977 Replication of prophage P1 during the cell cycle of Escherichia coli. Molecular & general genetics : MGG 91 325389
1987 Two DNA antirestriction systems of bacteriophage P1, darA, and darB: characterization of darA- phages. Virology 87 3029954
2004 PTEN regulates Mdm2 expression through the P1 promoter. The Journal of biological chemistry 84 15090541
2003 Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 76 12540498
2002 Solution structure of a luteoviral P1-P2 frameshifting mRNA pseudoknot. Journal of molecular biology 76 12225754
2010 Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors. Human pathology 74 21040949
2012 G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions. Purinergic signalling 72 22371149
1988 Analysis of the nucleotide sequence of the P1 operon of Mycoplasma pneumoniae. Gene 72 2468577
1970 Morphological variants of coliphage P1. Journal of virology 72 4193834
1988 Identification of P1 gene domain containing epitope(s) mediating Mycoplasma pneumoniae cytoadherence. The Journal of experimental medicine 69 2450165
1977 P1 and P3 proteins of influenza virus are required for complementary RNA synthesis. Journal of virology 69 850306
2000 Proteins complexed to the P1 adhesin of Mycoplasma pneumoniae. Microbiology (Reading, England) 67 10746778
1983 The conformation around the peptide bond between the P1- and P2-positions is important for catalytic activity of some proline-specific proteases. Biochimica et biophysica acta 66 6340741
2017 RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein Accumulation. Journal of virology 65 27974556
2004 Plasmid partitioning and the spreading of P1 partition protein ParB. Molecular microbiology 56 15130136
1987 Both P1 and P2 protamine genes are expressed in mouse, hamster, and rat. Biology of reproduction 54 3676400
2008 Host-specific effect of P1 exchange between two potyviruses. Molecular plant pathology 53 18705848
2015 Binding forces of Streptococcus mutans P1 adhesin. ACS nano 52 25671413
2002 Architecture of Fis-activated transcription complexes at the Escherichia coli rrnB P1 and rrnE P1 promoters. Journal of molecular biology 51 11866514
2014 Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems. Frontiers in immunology 49 24917862
2017 DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes. Scientific reports 48 28798419
2010 Micrococcin P1: structure, biology and synthesis. Natural product reports 48 20179875
1995 The tripartite immunity system of phages P1 and P7. FEMS microbiology reviews 48 7669337
1993 Evolution of protamine P1 genes in primates. Journal of molecular evolution 48 8308910
1997 Diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) controls the timing of cell division in Escherichia coli. Genes to cells : devoted to molecular & cellular mechanisms 46 9286857
2010 Partitioning of P1 plasmids by gradual distribution of the ATPase ParA. Molecular microbiology 44 21091504
1990 The c4 repressors of bacteriophages P1 and P7 are antisense RNAs. Cell 43 1696181
2013 The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures. Neuropharmacology 42 23541722
1996 Three functions of bacteriophage P1 involved in cell lysis. Journal of bacteriology 42 8576044
2015 Outer membrane protein P1 is the CEACAM-binding adhesin of Haemophilus influenzae. Molecular microbiology 41 26179342
1991 Primary structure of nuclease P1 from Penicillium citrinum. European journal of biochemistry 41 1915339
2017 The multicomponent antirestriction system of phage P1 is linked to capsid morphogenesis. Molecular microbiology 40 28509398
1987 P1 plasmid replication requires methylated DNA. The EMBO journal 39 2826133
2014 RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PloS one 38 24959908
2002 Loop-inserted and thermostabilized structure of P1-P1' cleaved ovalbumin mutant R339T. Journal of molecular biology 36 11779232
1993 Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus. The Journal of biological chemistry 36 8428967
2009 Rplp1 bypasses replicative senescence and contributes to transformation. Experimental cell research 35 19233166
1998 Cloning and expression of diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L. The Biochemical journal 35 9425114
1984 Stimulation of DNA synthesis by microinjection of diadenosine 5',5''-P1, P4-tetraphosphate (Ap4A) into Xenopus laevis oocytes. Developmental biology 35 6724135
2002 Genetic polymorphism of cytochrome P450 1A1 (Cyp1A1) and glutathione transferases (M1, T1 and P1) among Africans. Clinical chemistry and laboratory medicine 34 12435115
1989 Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase. Journal of bacteriology 34 2556364
2011 P1 peptidase--a mysterious protein of family Potyviridae. Journal of biosciences 33 21451259
2020 A Pd1-Ps-P1 Feedback Loop Controls Pubescence Density in Soybean. Molecular plant 32 33065270
2010 Uptake of Hydrocarbon by Pseudomonas fluorescens (P1) and Pseudomonas putida (K1) Strains in the Presence of Surfactants: A Cell Surface Modification. Water, air, and soil pollution 32 21258434
2012 Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. Life sciences 31 22580287
1994 Interaction of human P1 and P2 protamines with DNA. Biochemical and biophysical research communications 31 8024562
1990 Structure of the ecdysone-inducible P1 gene of Drosophila melanogaster. Journal of molecular biology 30 1696317
1989 The superimmunity gene sim of bacteriophage P1 causes superinfection exclusion. Virology 30 2763457
1991 Effect of regB on expression from the P1 and P2 promoters of the Pseudomonas aeruginosa regAB operon. Journal of bacteriology 29 1917842
1995 Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants. Journal of bacteriology 28 7730268
1989 Chromosomal localization and structure of the human P1 protamine gene. Genomics 28 2613245
2016 A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report. BMC cancer 27 27519597
2011 The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment. Life sciences 27 22100511
2020 CNN3 acts as a potential oncogene in cervical cancer by affecting RPLP1 mRNA expression. Scientific reports 26 32051425
2016 Transcriptional Auto-Regulation of RUNX1 P1 Promoter. PloS one 26 26901859
1989 Three additional operators, Op21, Op68, and Op88, of bacteriophage P1. Evidence for control of the P1 dam methylase by Op68. The Journal of biological chemistry 26 2536753
2020 Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins. Nucleic acids research 25 32890404
2010 Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase. Structure (London, England : 1993) 25 21070949
2006 Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography. Proceedings of the National Academy of Sciences of the United States of America 25 17038498
2003 Novel ubiquitin fusion proteins: ribosomal protein P1 and actin. Journal of molecular biology 25 12729753
1991 Null mutation in the stringent starvation protein of Escherichia coli disrupts lytic development of bacteriophage P1. Gene 25 1721886
1985 Transfection by genomic DNA of cytochrome P1-450 enzymatic activity and inducibility. Molecular and cellular biology 25 3990691
2008 BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety. Bioorganic & medicinal chemistry letters 24 18249539
1992 Transcriptional control via translational repression by c4 antisense RNA of bacteriophages P1 and P7. Genes & development 24 1459462
2022 The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy. Blood cancer journal 23 36347832
2021 bHLH transcription factors LP1 and LP2 regulate longitudinal cell elongation. Plant physiology 23 34618066
2008 Requirements for surface expression and function of adhesin P1 from Streptococcus mutans. Infection and immunity 23 18362133
2001 Complete nucleotide sequence of the mycoplasma virus P1 genome. Plasmid 23 11322826
1992 C1 repressor of phage P1 is inactivated by noncovalent binding of P1 Coi protein. The Journal of biological chemistry 23 1740459
1988 The c1 repressor of bacteriophage P1. Isolation and characterization of the repressor protein. The Journal of biological chemistry 23 2826478
1980 Mutations in coliphage p1 affecting host cell lysis. Journal of virology 23 16789200
2017 Development of novel LP1-based analogues with enhanced delta opioid receptor profile. Bioorganic & medicinal chemistry 22 28734666
1989 Organization of the immunity region immI of bacteriophage P1 and synthesis of the P1 antirepressor. Journal of molecular biology 22 2585500
1989 Protein-DNA interactions in regulation of P1 plasmid replication. Journal of bacteriology 21 2644199
2018 Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20 29603035
2008 P1 nuclease cleavage is dependent on length of the mismatches in DNA. DNA repair 20 18524693
2005 The response to cyclophosphamide in steroid-sensitive nephrotic syndrome is influenced by polymorphic expression of glutathion-S-transferases-M1 and -P1. Pediatric nephrology (Berlin, Germany) 20 15717164
2018 Mycoplasma pneumoniae induces allergy by producing P1-specific immunoglobulin E. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19 29555351
2008 alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. Peptides 19 18588930
2007 cDNA cloning and overexpression of acidic ribosomal phosphoprotein P1 gene (RPLP1) from the giant panda. International journal of biological sciences 19 18071584
2003 The involvement of diadenosine 5',5"'-P1,P4-tetraphosphate in cell cycle arrest and regulation of apoptosis. Biochemical pharmacology 19 12504798
2002 Neisseria gonorrhoeae porin P1.B induces endosome exocytosis and a redistribution of Lamp1 to the plasma membrane. Infection and immunity 19 12379671
1997 Epitope specificity of murine and human bactericidal antibodies against PorA P1.7,16 induced with experimental meningococcal group B vaccines. FEMS immunology and medical microbiology 19 9093834
1994 Substrate specificity of porcine renin: P1', P1, and P3 residues of renin substrates are crucial for activity. Biochemistry 19 7981226
2020 Isolation and Expansion of Neurospheres from Postnatal (P1-3) Mouse Neurogenic Niches. Journal of visualized experiments : JoVE 18 32510488
2016 Evaluation of N-substituent structural variations in opioid receptor profile of LP1. Bioorganic & medicinal chemistry 18 27234885
2015 A Novel Lactobacillus casei LP1 Producing 1,4-Dihydroxy-2-Naphthoic Acid, a Bifidogenic Growth Stimulator. Preventive nutrition and food science 18 25866754
2005 Crystal structure of an Anti-meningococcal subtype P1.4 PorA antibody provides basis for peptide-vaccine design. Journal of molecular biology 18 16038932
2016 Collectin CL-P1 utilizes C-reactive protein for complement activation. Biochimica et biophysica acta 17 26922829
1995 A YAC-, P1-, and cosmid-based physical map of the BRCA1 region on chromosome 17q21. Genomics 17 7774927