Affinage

TCF20

Transcription factor 20 · UniProt Q9UGU0

Length
1960 aa
Mass
211.8 kDa
Annotated
2026-06-10
44 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TCF20 (SPBP) is a large nuclear multidomain chromatin-binding transcriptional coregulator that tunes gene expression by docking on nucleosomes and partnering with sequence-specific transcription factors (PMID:10995766, PMID:22081970). It contains an N-terminal transactivating region, an AT-hook DNA-binding domain, a bipartite NLS, and a C-terminal ePHD/ADD zinc finger, and it engages chromatin through two independent nucleosome-interaction domains—a core region adjacent to the AT-hook (also required for nuclear localization) and the histone-tail-dependent ePHD/ADD domain—conferring low nuclear mobility and strong chromatin enrichment (PMID:10995766, PMID:22081970). As a coregulator it enhances the activity of c-Jun, Ets1, Sp1, and Pax6 (PMID:10995766), cooperates with TopBP1 on Ets1 target promoters such as c-myc and MMP3 (PMID:17913746), coactivates the androgen receptor at the probasin promoter in competition with Pax6 (PMID:21935435), and drives NRF2-dependent antioxidant transcription including p62/SQSTM1 (PMID:24416372); conversely it acts as a context-dependent repressor of phosphorylated, liganded estrogen receptor alpha, restraining ERα-dependent breast cancer cell proliferation (PMID:15831449). Its interactions are modulated by RNF4, which promotes SPBP-DNA complex formation and transactivation (PMID:10849425). In the nervous system TCF20 is essential for cortical neurogenesis, acting through a TCF20→TDG→TCF-4 axis in which TDG-controlled DNA methylation at the TCF-4 promoter governs neural differentiation (PMID:32510763), and it controls dendritic arborization, spine formation, and pre-/postsynaptic protein expression (PMID:39801227). TCF20 assembles into a brain chromatin complex with MeCP2 (and PHF14) to coregulate neuronal genes, an interaction disrupted by Rett-causing MECP2 mutations and by patient PHF14 mutations (PMID:35074918). Loss-of-function TCF20 mutations are associated with autism spectrum disorder (PMID:25228304).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2000 Medium

    Established TCF20/SPBP as a multidomain nuclear transcriptional coactivator, defining its functional architecture and first transcription-factor targets.

    Evidence Domain mapping by deletion analysis and cotransfection reporter assays with c-Jun, Ets1, Sp1, Pax6

    PMID:10995766

    Open questions at the time
    • No endogenous target genes identified
    • Coactivation shown only in overexpression reporter context
  2. 2000 Medium

    Identified RNF4 as a physical cofactor that potentiates SPBP-DNA complex formation and transactivation, and showed the internal PHD/LAP zinc finger autoregulates this interaction.

    Evidence In vitro EMSA binding, cotransfection transactivation assays, domain mapping

    PMID:10849425

    Open questions at the time
    • Mechanism of RNF4-enhanced DNA binding unresolved
    • No genome-wide co-occupancy data
  3. 2005 High

    Showed phosphorylation-dependent recruitment of SPBP to ERα AF1 and a repressive role on activated ERα, establishing context-dependent repressor function and a phospho-specific recognition mode.

    Evidence Phage display for phosphoserine binders, purified in vitro binding with phosphomimic S118E, cellular co-IP, proliferation assay in ERα-dependent breast cancer lines

    PMID:15831449

    Open questions at the time
    • Switch between coactivator and corepressor roles not mechanistically defined
    • Endogenous ERα target genes not profiled
  4. 2007 High

    Defined a TopBP1 partnership through reciprocal domain interactions, placing SPBP on endogenous Ets1 promoters with a functional secretion phenotype.

    Evidence Yeast two-hybrid, in vitro binding, co-IP, ChIP on c-myc/MMP3 promoters, siRNA knockdown reducing MMP3 secretion

    PMID:17913746

    Open questions at the time
    • Structural basis of ePHD-BRCT6 contact unknown
    • Breadth of TopBP1-SPBP coregulated genes not mapped
  5. 2011 Medium

    Demonstrated SPBP coactivation of the androgen receptor and competitive antagonism by Pax6, linking coregulator recruitment to DNA-binding-domain contacts.

    Evidence Cotransfection reporters, ChIP on probasin promoter, co-IP and domain mapping

    PMID:21935435

    Open questions at the time
    • Physiological relevance in prostate tissue not tested
    • Competition shown in overexpression context
  6. 2012 High

    Resolved how SPBP physically engages chromatin, identifying two independent nucleosome-binding domains and linking one to nuclear localization.

    Evidence In vitro nucleosome-binding with deletion constructs, FRAP, nuclear fractionation, immunofluorescence in HeLa

    PMID:22081970

    Open questions at the time
    • Histone modification specificity of ePHD/ADD binding not defined
    • In vivo genome-wide nucleosome targeting unknown
  7. 2013 Medium

    Established evolutionary conservation and cross-braced zinc-finger topology of the SPBP C-terminal region, generalizing nucleosome-binding to the RAI1 homologue.

    Evidence Phylogenetic analysis, in vitro and yeast-cell interaction studies

    PMID:24205348

    Open questions at the time
    • No experimentally determined high-resolution structure
    • Functional consequence of conservation untested in vivo
  8. 2014 Medium

    Placed SPBP within the NRF2 antioxidant program as a coactivator driving p62/SQSTM1 and autophagy-linked gene expression.

    Evidence ARE reporter assays, siRNA knockdown with IF/Western, cotransfection synergy, colocalization in nuclear speckles

    PMID:24416372

    Open questions at the time
    • Direct SPBP-NRF2 contact not mapped
    • ARE occupancy by SPBP not shown by ChIP
  9. 2014 Low

    Linked TCF20 loss-of-function mutations to autism spectrum disorder, connecting the coregulator to human neurodevelopmental disease.

    Evidence Cytogenetics, Sanger sequencing of TCF20 ORFs, exome sequencing identifying de novo and inherited variants

    PMID:25228304

    Open questions at the time
    • Genetic association without protein-level functional assays in this study
    • Causal mechanism of variants undefined
  10. 2020 High

    Defined a developmental signaling axis showing TCF20 is required for cortical neurogenesis via TDG-mediated DNA demethylation controlling TCF-4.

    Evidence Conditional knockout mice, RNA-seq, ChIP-qPCR identifying TDG, epistasis rescue by TDG/TCF-4 overexpression

    PMID:32510763

    Open questions at the time
    • Direct TCF20 binding at the TDG locus vs indirect effect not fully separated
    • Whether TCF20 acts as activator or repressor of TDG unresolved
  11. 2022 High

    Identified the MeCP2-TCF20 chromatin complex and showed its disruption underlies Rett and MECP2 duplication phenotypes, integrating TCF20 into a neuronal epigenetic regulatory module.

    Evidence BioID proteomics, co-IP, in vivo genetic epistasis (Tcf20 reduction rescuing MECP2 overexpression mice), patient PHF14 mutation validation

    PMID:35074918

    Open questions at the time
    • Stoichiometry and assembly order of the complex unknown
    • Genome-wide MeCP2-TCF20 co-regulated targets only partially defined
  12. 2023 Medium

    Broadened TCF20 phenotypes beyond brain, revealing roles in liver fibrosis, ECM gene regulation, and mitochondrial metabolism in knockout mice.

    Evidence Homologous recombination knockout, Seahorse metabolic assays, GC-MS proteomics, gene expression and behavioral phenotyping

    PMID:37312667

    Open questions at the time
    • Direct transcriptional targets driving metabolic phenotype not identified
    • Tissue-specific mechanisms not separated from systemic effects
  13. 2025 Medium

    Demonstrated TCF20 control of dendritic arborization, spine formation, and synaptic protein expression, mechanistically linking it to synaptic gene programs.

    Evidence siRNA knockdown in rat cortical cultures, RNA-seq, synaptosomal Western blots, dendritic morphology imaging

    PMID:39801227

    Open questions at the time
    • Direct vs indirect regulation of individual synaptic genes not distinguished
    • Whether changes reflect transcriptional coregulation by TCF20 at these loci untested
  14. 2025 Medium

    Extended MeCP2-TCF20 complex function to osteogenesis, showing it suppresses HDAC1 to activate Wnt/β-catenin signaling in periodontal ligament stem cells.

    Evidence IP-MS, RNA-seq, siRNA/overexpression, Western blot, ALP/ARS osteogenic assays

    PMID:41094547

    Open questions at the time
    • Direct complex occupancy at the HDAC1 locus not shown
    • Generalizability beyond this stem cell context unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TCF20 switches between coactivation and corepression, and what determines its genome-wide chromatin targeting within the MeCP2/RAI1/PHF14/HMG20A complex, remains unresolved.
  • No high-resolution structure of TCF20 domains or complex
  • Genome-wide direct binding map lacking
  • Determinants of activator-vs-repressor behavior undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 5 GO:0042393 histone binding 2 GO:0060090 molecular adaptor activity 2 GO:0003677 DNA binding 1
Localization
GO:0000228 nuclear chromosome 2 GO:0005634 nucleus 2 GO:0005654 nucleoplasm 1
Pathway
R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1266738 Developmental Biology 2 R-HSA-4839726 Chromatin organization 2 R-HSA-8953897 Cellular responses to stimuli 1
Partners
ARESR1ETS1MECP2PAX6PHF14RNF4TOPBP1
Complex memberships
MeCP2-TCF20-PHF14 chromatin complexTCF20/PHF14 brain chromatin complex (MeCP2, RAI1, TCF20, PHF14, HMG20A)

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 SPBP (TCF20) is a nuclear multidomain protein containing an N-terminal transactivating region, a novel DNA-binding domain with an AT-hook motif, a bipartite nuclear localization signal, and a C-terminal zinc finger domain of the trithorax family. It functions as a transcriptional coactivator, enhancing the transcriptional activity of c-Jun, Ets1, Sp1, and Pax6 in cotransfection experiments. Functional domain mapping by deletion analysis, cotransfection reporter assays, PCR analyses of multitissue cDNA panels, cDNA cloning and sequencing The Journal of biological chemistry Medium 10995766
2000 SPBP (TCF20) physically interacts with the RING finger protein RNF4; both are ubiquitously expressed nuclear proteins. RNF4 facilitates accumulation of specific SPBP-DNA complexes in vitro and acts as a positive cofactor in SPBP-mediated transactivation. SPBP's internal PHD/LAP-type zinc finger domain can form intra-chain protein-protein contacts that negatively modulate the SPBP-RNF4 interaction. In vitro binding assays (EMSA), cotransfection transactivation assays, domain mapping of the PHD/LAP zinc finger interaction The Journal of biological chemistry Medium 10849425
2005 SPBP (TCF20) is recruited exclusively to the phosphorylated form of estrogen receptor alpha (ERα) AF1 domain. In a purified system, SPBP bound only in vitro-phosphorylated ERα AF1 or the phosphoserine mimic S118E, with the interaction domain mapped to a 42-amino-acid fragment of SPBP. In cells, SPBP preferentially interacted with liganded and phosphorylated ERα and functioned as a repressor of activated ERα, inhibiting proliferation of ERα-dependent breast cancer cell lines. Phage display screen for phosphoserine-specific binders, in vitro binding assay with purified proteins and phosphoserine mimic, co-immunoprecipitation in cells, cell proliferation assay Molecular and cellular biology High 15831449
2007 SPBP (TCF20) physically interacts with TopBP1 via the ePHD domain of SPBP and the BRCT6 domain of TopBP1. Together they cooperate as co-activators of Ets1 on c-myc P1P2 and MMP3 promoters with more-than-additive effect. Both proteins associate with these promoters. Depletion of SPBP by siRNA reduced MMP3 secretion by 50% in phorbol ester-stimulated human fibroblasts. Yeast two-hybrid screen, in vitro binding confirmation, co-immunoprecipitation in vivo, chromatin immunoprecipitation (ChIP), reporter assays, siRNA knockdown Nucleic acids research High 17913746
2011 SPBP (TCF20) acts as a transcriptional coactivator of the androgen receptor (AR), enhancing AR activity on the probasin promoter. Pax6 represses AR-mediated transactivation by competing with SPBP for binding to AR, reducing SPBP recruitment to the probasin promoter. The interaction between AR and SPBP, and between AR and Pax6, was mapped to the DNA-binding domains of the respective proteins. Cotransfection reporter assays, chromatin immunoprecipitation (ChIP), co-immunoprecipitation and domain-mapping binding studies PloS one Medium 21935435
2012 SPBP (TCF20) contains two independent nucleosome-binding domains: a novel core nucleosome-interaction domain at residues 1551–1666 (adjacent to the AT-hook motif) and the C-terminal ePHD/ADD domain that associates with nucleosomes in a histone tail-dependent manner. The 1551–1666 region is critically important for proper nuclear localization of SPBP. Both SPBP and its homologue RAI1 are strongly enriched on chromatin in interphase HeLa cells and display low nuclear mobility. In vitro nucleosome-binding assays with domain deletion constructs, fluorescence recovery after photobleaching (FRAP), nuclear fractionation, immunofluorescence The Biochemical journal High 22081970
2013 The ePHD/ADD-like domain and novel nucleosome-binding domain of SPBP (TCF20) are highly conserved in vertebrate evolution. In vitro and yeast-cell interaction studies showed the C-terminal region adopts a cross-braced topology of zinc finger interactions similar to other structurally determined ePHD/ADD domains. Experimental data confirmed that the conserved novel nucleosome-binding region of RAI1 (homologue) can bind nucleosome core and histones. Phylogenetic analysis, in vitro interaction studies, yeast cell interaction assays, evolutionary conservation analysis PloS one Medium 24205348
2014 SPBP (TCF20) functions as a transcriptional coactivator of NRF2. Sulforaphane induces SPBP expression, and SPBP stimulates p62/SQSTM1 expression via ARE elements in its promoter. siRNA-mediated knockdown of SPBP significantly decreases p62/SQSTM1 expression and p62 body formation in HeLa cells, and reduces sulforaphane-induced NRF2 and LC3B expression. Overexpressed SPBP and NRF2 act synergistically on the p62/SQSTM1 promoter and colocalize in nuclear speckles. Reporter gene assays (ARE-driven promoters), siRNA knockdown with immunofluorescence and Western blot, cotransfection synergy assay, colocalization by fluorescence microscopy PloS one Medium 24416372
2014 TCF20 is a transcriptional coregulator structurally and functionally related to RAI1; de novo and rare inherited loss-of-function mutations in TCF20 are associated with autism spectrum disorder. A de novo missense and frameshift mutations in TCF20 were identified, supporting TCF20 as an ASD-associated gene. Cytogenetic characterization (FISH, Southern blotting, inverse PCR), Sanger sequencing of TCF20 open reading frames, exome sequencing Journal of medical genetics Low 25228304
2020 TCF20 is essential for cortical neurogenesis in mice. TCF20 deletion reduces neuron number and causes abnormal brain function. ChIP-qPCR and transcriptome analysis identified TDG (DNA demethylation factor) as a downstream target gene of TCF20. TDG controls DNA methylation at the TCF-4 promoter, affecting TCF-4 expression and neural differentiation. Overexpression of TDG or TCF-4 rescues neurogenesis deficits caused by TCF20 knockdown. Conditional knockout mouse model, RNA-seq transcriptome analysis, ChIP-qPCR, rescue experiments by overexpression, immunofluorescence EMBO reports High 32510763
2022 TCF20 forms a complex with MeCP2 at the chromatin interface. RTT-causing mutations in MECP2 disrupt the MeCP2-TCF20 interaction. TCF20 and MeCP2 are highly coexpressed in neurons and coregulate key neuronal gene expression. Reducing Tcf20 partially rescued behavioral deficits caused by MECP2 overexpression in mice (MECP2 duplication syndrome model). A PHF14 missense mutation in a patient abolishes the MeCP2-PHF14-TCF20 interaction. Proximity-dependent biotinylation (BioID) proteomics, co-immunoprecipitation, genetic epistasis in mouse behavioral model (Tcf20 reduction in MECP2 overexpression mice), patient mutation functional validation Proceedings of the National Academy of Sciences of the United States of America High 35074918
2023 Tcf20 knockout in mice results in impaired neural development and neonatal death. Heterozygous Tcf20 mice show higher CCl4-induced liver fibrosis and differential expression of extracellular matrix homeostasis genes, along with autism-like behavioral phenotypes. Tcf20-null embryonic livers and MEF cells show differential expression of mitochondrial oxidative phosphorylation proteins, increased mitochondrial metabolic activity, and altered citric acid cycle metabolites. Homologous recombination knockout mouse, Seahorse metabolic analysis, gas chromatography-mass spectrometry proteomics, gene expression analysis, behavioral phenotyping Liver international Medium 37312667
2025 TCF20 plays a central role in dendritic arborization and dendritic spine formation in neurons. TCF20 knockdown in rat cortical cultures causes downregulation of pre- and postsynaptic pathways and reduced levels of GABRA1, BDNF, PSD-95, c-Fos, GluN2B, and GABRA5, with upregulation of GluA2, in both total homogenates and synaptosomal preparations. siRNA knockdown in rat cortical cultures, RNA sequencing, Western blot of synaptosomal fractions, immunofluorescence for dendritic morphology Journal of neurochemistry Medium 39801227
2025 The MeCP2-TCF20 complex directly suppresses HDAC1 expression in periodontal ligament stem cells, thereby activating the Wnt/β-catenin signaling pathway and promoting osteogenic differentiation. M2 macrophage-derived exosomes activate the MeCP2-TCF20 complex in this context. Immunoprecipitation-mass spectrometry (IP-MS), RNA sequencing, siRNA knockdown and overexpression validation, Western blot, ALP/ARS osteogenic assays Stem cell research & therapy Medium 41094547
2024 The TCF20/PHF14 chromatin complex in the mammalian brain includes MeCP2, RAI1, TCF20, PHF14, and HMG20A, and plays a role in epigenetic and transcriptional regulation. Mutations in genes encoding components of this complex are linked to neurodevelopmental disorders. Review and synthesis of existing experimental findings from prior BioID, co-IP, and genetic studies (no new primary experiments reported in this review paper) Genes Low 39766920

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. The Journal of biological chemistry 49 10995766
2000 Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. The Journal of biological chemistry 44 10849425
1997 HlyX, the FNR homologue of Actinobacillus pleuropneumoniae, is a [4Fe-4S]-containing oxygen-responsive transcription regulator that anaerobically activates FNR-dependent class I promoters via an enhanced AR1 contact. Molecular microbiology 40 9179852
2019 De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome. Genome medicine 39 30819258
2005 SPBP is a phosphoserine-specific repressor of estrogen receptor alpha. Molecular and cellular biology 39 15831449
2022 Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Proceedings of the National Academy of Sciences of the United States of America 37 35074918
2014 De novo and rare inherited mutations implicate the transcriptional coregulator TCF20/SPBP in autism spectrum disorder. Journal of medical genetics 36 25228304
2014 SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. PloS one 35 24416372
2011 T4-Like genome organization of the Escherichia coli O157:H7 lytic phage AR1. Journal of virology 32 21507986
2016 De novo nonsense and frameshift variants of TCF20 in individuals with intellectual disability and postnatal overgrowth. European journal of human genetics : EJHG 31 27436265
2000 Characterization of the distal tail fiber locus and determination of the receptor for phage AR1, which specifically infects Escherichia coli O157:H7. Journal of bacteriology 31 11029414
2020 TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice. EMBO reports 27 32510763
2012 Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP. The Biochemical journal 27 22081970
1998 Downregulation of Escherichia coli yfiD expression by FNR occupying a site at -93.5 involves the AR1-containing face of FNR. Molecular microbiology 25 9767578
2007 The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. Nucleic acids research 24 17913746
2000 Two distinct pathways for anaerobic degradation of aromatic compounds in the denitrifying bacterium Thauera aromatica strain AR-1. Archives of microbiology 23 10795679
1991 endAFS, a novel family E endoglucanase gene from Fibrobacter succinogenes AR1. Journal of bacteriology 21 1708767
2013 A phylogenetic study of SPBP and RAI1: evolutionary conservation of chromatin binding modules. PloS one 20 24205348
1998 Anaerobic degradation of alpha-resorcylate by Thauera aromatica strain AR-1 proceeds via oxidation and decarboxylation to hydroxyhydroquinone. Archives of microbiology 19 9531634
2002 Anaerobic degradation of protocatechuate (3,4-dihydroxybenzoate) by Thauera aromatica strain AR-1. FEMS microbiology letters 17 12076800
2011 Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP. PloS one 16 21935435
1998 AR1 is an integral part of the adenovirus type 2 E1A-CR3 transactivation domain. Journal of virology 15 9621060
2018 A previously unrecognized 22q13.2 microdeletion syndrome that encompasses TCF20 and TNFRSF13C. American journal of medical genetics. Part A 14 30216695
2012 Characterization and genetic analysis of an EIN4-like sequence (CaETR-1) located in QTL(AR1) implicated in ascochyta blight resistance in chickpea. Plant cell reports 14 22238063
2021 Rare and de novo duplications containing TCF20 are associated with a neurodevelopmental disorder. Clinical genetics 12 34904221
2019 DbdR, a New Member of the LysR Family of Transcriptional Regulators, Coordinately Controls Four Promoters in the Thauera aromatica AR-1 3,5-Dihydroxybenzoate Anaerobic Degradation Pathway. Applied and environmental microbiology 12 30389770
2015 Identification of the Gene Cluster for the Anaerobic Degradation of 3,5-Dihydroxybenzoate (α-Resorcylate) in Thauera aromatica Strain AR-1. Applied and environmental microbiology 12 26253674
1991 Molecular cloning, expression, and characterization of endoglucanase genes from Fibrobacter succinogenes AR1. Applied and environmental microbiology 12 2014986
2023 A syndrome featuring developmental disorder of the nervous system induced by a novel mutation in the TCF20 gene, rarely concurrent immune disorders: a case report. Frontiers in genetics 5 37303953
2023 Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans. Liver international : official journal of the International Association for the Study of the Liver 5 37312667
2023 Electrochemical oxidation of azo dyes degradation by RuO2-IrO2-TiO2 electrode with biodegradation Aeromonas hydrophila AR1 and its degradation pathway: An integrated approach. Chemosphere 5 37879370
1985 Detection of human pancreatic adenocarcinomas by histochemical staining with monoclonal antibody AR1-28. Diagnostic immunology 5 3899466
2024 Epigenetic Regulation and Neurodevelopmental Disorders: From MeCP2 to the TCF20/PHF14 Complex. Genes 4 39766920
1987 Reactivity of monoclonal anti-human pancreatic carcinoma antibodies AR2-20 and AR1-28 with tumors of nonpancreatic origin. The American journal of pathology 4 2433945
2025 Regulation of Dendrite and Dendritic Spine Formation by TCF20. Journal of neurochemistry 3 39801227
1991 The involvement of transcriptional read-through from internal promoters in the expression of a novel endoglucanase gene FSendA, from Fibrobacter succinogenes AR1. Nucleic acids research 3 2027774
2025 M2-exo promote orthodontic bone remodeling via the MeCP2-TCF20-HDAC1 axis. Stem cell research & therapy 2 41094547
2011 Surveillance of single-cell behavior in different subpopulations of Ralstonia pickettii AR1 during growth and polyhydroxybutyrate production phases by flow cytometry. Journal of basic microbiology 2 21780145
2002 Analysis of the baseplate region of phage AR1 that specifically infects Escherichia coli O157:H7. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2 12542256
2024 Association Between CYP2D7 and TCF20 Polymorphisms and Coronary Heart Disease. Cardiovascular toxicology 1 39060884
2024 Chemical Characterization and In Vitro Evaluation of Glucans from Fermentation-Produced Nutraceutical Bionutri-AR1®: Antioxidant and Immunomodulatory Properties. Pharmaceutics 1 39598528
2003 Human act and AR1 sequences differentially regulate murine and human D1A dopamine receptor promoters. Molecules and cells 1 12872983
2025 Germline mosaicism in TCF20-associated neurodevelopmental disorders: a case study and literature review. Journal of human genetics 0 40011607
2025 A Boy with a Novel Variant in TCF20: An Expanded Phenotype and a Brief Review of the Literature. Children (Basel, Switzerland) 0 41300659

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