- Length
- 190 aa
- Mass
- 21.3 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
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Mechanism profile
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Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2008 | RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. | Nature cell biology | 691 | 18408734 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2008 | Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. | Nature cell biology | 607 | 18408733 |
| 2010 | An atlas of combinatorial transcriptional regulation in mouse and man. | Cell | 573 | 20211142 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2005 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | Genome research | 409 | 16344560 |
| 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. | Genome research | 401 | 8889548 |
| 2001 | The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A. | Human molecular genetics | 299 | 11726556 |
| 2007 | SUMO-targeted ubiquitin ligases in genome stability. | The EMBO journal | 293 | 17762865 |
| 2017 | Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. | Proceedings of the National Academy of Sciences of the United States of America | 282 | 28611215 |
| 2012 | RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. | Genes & development | 276 | 22661229 |
| 2007 | Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. | The EMBO journal | 251 | 17762864 |
| 2004 | Functional proteomics mapping of a human signaling pathway. | Genome research | 247 | 15231748 |
| 2019 | Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. | ACS chemical biology | 245 | 31059647 |
| 2012 | SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. | Genes & development | 209 | 22661230 |
| 2014 | Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins. | The Journal of cell biology | 185 | 24637324 |
| 1998 | Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. | Molecular and cellular biology | 177 | 9710597 |
| 2013 | The protein interaction landscape of the human CMGC kinase group. | Cell reports | 174 | 23602568 |
| 2010 | A human MAP kinase interactome. | Nature methods | 165 | 20936779 |
| 2014 | A cellular system that degrades misfolded proteins and protects against neurodegeneration. | Molecular cell | 157 | 24882209 |
| 2012 | RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. | Science signaling | 153 | 23211528 |
| 2011 | Mechanism of ubiquitylation by dimeric RING ligase RNF4. | Nature structural & molecular biology | 149 | 21857666 |
| 2017 | RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. | BMC biology | 135 | 29117863 |
| 2011 | Purification and identification of endogenous polySUMO conjugates. | EMBO reports | 134 | 21252943 |
| 2004 | Regulation of the large (approximately 1000 kb) imprinted murine Ube3a antisense transcript by alternative exons upstream of Snurf/Snrpn. | Nucleic acids research | 134 | 15226413 |
| 2009 | A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. | Molecular systems biology | 130 | 19690564 |
| 2009 | Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. | Genome research | 129 | 19549727 |
| 2007 | The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination. | Molecular and cellular biology | 124 | 17591698 |
| 2022 | The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin. | Nature cell biology | 122 | 35013556 |
| 2016 | USP7 is a SUMO deubiquitinase essential for DNA replication. | Nature structural & molecular biology | 119 | 26950370 |
| 2007 | Toward a confocal subcellular atlas of the human proteome. | Molecular & cellular proteomics : MCP | 114 | 18029348 |
| 2020 | A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation. | Science advances | 112 | 33188014 |
| 2010 | The SUMO protease SENP6 is essential for inner kinetochore assembly. | The Journal of cell biology | 108 | 20212317 |
| 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | Molecular medicine (Cambridge, Mass.) | 108 | 20379614 |
| 2021 | Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity. | Nature communications | 107 | 34599178 |
| 2016 | PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. | Genes & development | 103 | 27056668 |
| 2020 | The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules. | Molecular cell | 101 | 32521226 |
| 2012 | RNF4 is required for DNA double-strand break repair in vivo. | Cell death and differentiation | 100 | 23197296 |
| 2004 | Negative modulation of androgen receptor transcriptional activity by Daxx. | Molecular and cellular biology | 98 | 15572661 |
| 2015 | Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains. | Nature structural & molecular biology | 97 | 26148049 |
| 2000 | The RING finger protein SNURF modulates nuclear trafficking of the androgen receptor. | Journal of cell science | 95 | 10934038 |
| 2013 | RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. | Genes & development | 91 | 24142876 |
| 2015 | c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. | Cell cycle (Georgetown, Tex.) | 87 | 25895136 |
| 2008 | Activation of the Slx5-Slx8 ubiquitin ligase by poly-small ubiquitin-like modifier conjugates. | The Journal of biological chemistry | 86 | 18499666 |
| 2005 | Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae. | DNA repair | 86 | 16325482 |
| 2017 | The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. | Nature communications | 85 | 29180619 |
| 2000 | A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. | The Journal of biological chemistry | 81 | 10713105 |
| 2009 | RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. | Nucleic acids research | 79 | 20026589 |
| 2014 | SUMO chain-induced dimerization activates RNF4. | Molecular cell | 72 | 24656128 |
| 2010 | RING domain dimerization is essential for RNF4 function. | The Biochemical journal | 72 | 20681948 |
| 2017 | Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4. | The EMBO journal | 71 | 28275011 |
| 2013 | Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements. | PLoS genetics | 71 | 23935535 |
| 2010 | Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. | Molecular biology of the cell | 68 | 20943951 |
| 2016 | SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin. | Molecular biology of the cell | 67 | 26960795 |
| 2014 | ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation. | Blood | 65 | 25395419 |
| 2005 | Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae. | Genetics | 65 | 16387868 |
| 2000 | Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms. | The Journal of biological chemistry | 65 | 10617653 |
| 2004 | SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies. | Experimental cell research | 63 | 15707587 |
| 2007 | Fission yeast Rnf4 homologs are required for DNA repair. | The Journal of biological chemistry | 61 | 17502373 |
| 2010 | Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen. | Proceedings of the National Academy of Sciences of the United States of America | 58 | 20696907 |
| 2021 | Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway. | The EMBO journal | 57 | 34346517 |
| 2017 | Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis. | Molecular therapy : the journal of the American Society of Gene Therapy | 55 | 28143738 |
| 2009 | Role of SUMO in RNF4-mediated promyelocytic leukemia protein (PML) degradation: sumoylation of PML and phospho-switch control of its SUMO binding domain dissected in living cells. | The Journal of biological chemistry | 51 | 19380586 |
| 2001 | A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15. | Human molecular genetics | 51 | 11159938 |
| 2016 | RNF4-Dependent Oncogene Activation by Protein Stabilization. | Cell reports | 48 | 27653698 |
| 2011 | The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax. | Blood | 47 | 22106342 |
| 2010 | Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase. | Molecular and cellular biology | 46 | 20516210 |
| 2016 | miR-762 promotes porcine immature Sertoli cell growth via the ring finger protein 4 (RNF4) gene. | Scientific reports | 45 | 27596571 |
| 2023 | Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. | Molecular cell | 44 | 37059091 |
| 2014 | RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. | EMBO reports | 44 | 24714598 |
| 2007 | Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathway. | DNA repair | 44 | 17669696 |
| 2004 | Transcriptional coregulator SNURF (RNF4) possesses ubiquitin E3 ligase activity. | FEBS letters | 44 | 14987998 |
| 2004 | SNURF-SNRPN and UBE3A transcript levels in patients with Angelman syndrome. | Human genetics | 44 | 15014980 |
| 2003 | The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. | The Journal of biological chemistry | 44 | 12885770 |
| 2001 | RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors. | The American journal of pathology | 44 | 11583949 |
| 2000 | Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. | The Journal of biological chemistry | 44 | 10849425 |
| 2014 | An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress. | The Journal of biological chemistry | 41 | 24907272 |
| 2014 | PML, SUMO, and RNF4: guardians of nuclear protein quality. | Molecular cell | 40 | 24996060 |
| 2012 | Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms. | PloS one | 39 | 23028697 |
| 2004 | Influence of in vitro manipulation on the stability of methylation patterns in the Snurf/Snrpn-imprinting region in mouse embryonic stem cells. | Nucleic acids research | 39 | 15004243 |
| 2003 | Translational regulation of a novel testis-specific RNF4 transcript. | Molecular reproduction and development | 39 | 12874792 |
| 2015 | RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway. | The Journal of clinical investigation | 36 | 25751062 |
| 2015 | Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4). | The Journal of biological chemistry | 36 | 25969536 |
| 2005 | Characterization of cis- and trans-acting elements in the imprinted human SNURF-SNRPN locus. | Nucleic acids research | 36 | 16116039 |
| 2016 | Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression. | Cell reports | 35 | 27134171 |
| 2009 | The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. | Cell cycle (Georgetown, Tex.) | 35 | 19270524 |
| 2007 | The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity. | Cell cycle (Georgetown, Tex.) | 35 | 18032921 |
| 2006 | Purification of the yeast Slx5-Slx8 protein complex and characterization of its DNA-binding activity. | Nucleic acids research | 35 | 17020915 |
| 2001 | Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. | The Journal of biological chemistry | 35 | 11696545 |
| 2010 | Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference. | BMC cancer | 33 | 20167086 |
| 2001 | PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. | The Journal of biological chemistry | 33 | 11719514 |
| 2019 | RNF4-A Paradigm for SUMOylation-Mediated Ubiquitination. | Proteomics | 32 | 31566917 |
| 2024 | Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation. | Nature structural & molecular biology | 31 | 38649616 |
| 2009 | Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis. | European journal of human genetics : EJHG | 31 | 19471314 |
| 2006 | Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells. | Stem cells (Dayton, Ohio) | 31 | 17170068 |
| 1998 | Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3. | Genomics | 31 | 9479498 |
| 2015 | CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase. | Nucleic acids research | 28 | 25948581 |
| 2013 | Role of RNF4 in the ubiquitination of Rta of Epstein-Barr virus. | The Journal of biological chemistry | 28 | 23504328 |
| 2003 | Down-regulation of estrogen receptor beta and transcriptional coregulator SNURF/RNF4 in testicular germ cell cancer. | European urology | 28 | 14644130 |
| 2000 | Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region. | Developmental dynamics : an official publication of the American Association of Anatomists | 27 | 10822263 |
| 2007 | Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. | Molecular and cellular biology | 26 | 18086879 |
| 2015 | RNF4 negatively regulates NF-κB signaling by down-regulating TAB2. | FEBS letters | 25 | 26299341 |
| 2014 | Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain. | The Biochemical journal | 25 | 24844634 |
| 2008 | Identification of polymorphism and association analysis with reproductive traits in the porcine RNF4 gene. | Animal reproduction science | 24 | 18358646 |
| 2016 | RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. | Cell cycle (Georgetown, Tex.) | 23 | 26766492 |
| 2001 | The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity. | The Journal of biological chemistry | 23 | 11319220 |
| 2013 | Small mosaic deletion encompassing the snoRNAs and SNURF-SNRPN results in an atypical Prader-Willi syndrome phenotype. | American journal of medical genetics. Part A | 22 | 24311433 |
| 2019 | SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models. | Disease models & mechanisms | 21 | 30559154 |
| 2014 | Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells. | DNA repair | 21 | 25588990 |
| 2006 | Expression of the Snurf-Snrpn IC transcript in the oocyte and its putative role in the imprinting establishment of the mouse 7C imprinting domain. | Journal of human genetics | 21 | 16429232 |
| 2017 | A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR. | Journal of molecular cell biology | 20 | 28201649 |
| 2002 | Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice. | Human molecular genetics | 19 | 12075010 |
| 2022 | RNF4 controls the extent of replication fork reversal to preserve genome stability. | Nucleic acids research | 18 | 35640614 |
| 2020 | Knockdown of endogenous RNF4 exacerbates ischaemia-induced cardiomyocyte apoptosis in mice. | Journal of cellular and molecular medicine | 18 | 32722882 |
| 2018 | Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation. | Nature communications | 18 | 30479332 |
| 2017 | The Epstein-Barr virus miR-BHRF1-1 targets RNF4 during productive infection to promote the accumulation of SUMO conjugates and the release of infectious virus. | PLoS pathogens | 17 | 28414785 |
| 2002 | Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation. | Mechanisms of development | 17 | 12351196 |
| 2022 | DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR. | DNA repair | 16 | 35124373 |
| 2016 | A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability. | Cellular signalling | 16 | 27312341 |
| 2007 | Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter. | Journal of human genetics | 16 | 17262171 |
| 2024 | WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis. | Nature communications | 15 | 39025847 |
| 2020 | Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance. | The Journal of investigative dermatology | 15 | 32360601 |
| 2014 | SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. | Genes to cells : devoted to molecular & cellular mechanisms | 15 | 25205350 |
| 2021 | RNF4 Regulates the BLM Helicase in Recovery From Replication Fork Collapse. | Frontiers in genetics | 14 | 34868226 |
| 2021 | RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1. | EMBO reports | 14 | 34897944 |
| 2017 | A novel deletion of SNURF/SNRPN exon 1 in a patient with Prader-Willi-like phenotype. | European journal of medical genetics | 14 | 28554868 |
| 2021 | The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1. | International journal of molecular sciences | 13 | 34071450 |