Affinage

UBE2D1

Ubiquitin-conjugating enzyme E2 D1 · UniProt P51668

Round 2 corrected
Length
147 aa
Mass
16.6 kDa
Annotated
2026-04-28
68 papers in source corpus 13 papers cited in narrative 13 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

UBE2D1 (UbcH5A) is a promiscuous E2 ubiquitin-conjugating enzyme that partners with a broad spectrum of RING-domain and U-box E3 ubiquitin ligases to catalyze both K48- and K63-linked polyubiquitination, thereby regulating the stability and trafficking of diverse substrates central to tumor suppression, hypoxia response, NF-κB signaling, and protein quality control. Reconstituted biochemistry has demonstrated UBE2D1 as a functional E2 for MDM2-mediated p53 ubiquitination (PMID:9450543), VHL complex–dependent HIF1α ubiquitination (PMID:10973499), BRCA1-BARD1 polyubiquitin chain assembly (PMID:11278247), CHIP-directed chaperone substrate ubiquitination (PMID:11557750), A20-catalyzed K48-linked ubiquitination of RIP1 (PMID:15258597), RNF4-mediated degradation of poly-SUMO-modified PML (PMID:18408734), and TRAF2-dependent K63-linked ubiquitination of RIP1 stimulated by sphingosine-1-phosphate (PMID:20577214). In ribosome-associated quality control, the cofactor TCF25 orients the acceptor ubiquitin on the UBE2D1~Ub thioester to impose K48-linkage specificity during Listerin-mediated ubiquitination of stalled nascent chains [PMID:bio_10.1101_2024.10.17.618946]. Selective inhibition of the UBE2D family in cells increases the abundance of approximately 20% of the detectable proteome, underscoring UBE2D1's central role in global ubiquitin-dependent proteostasis [PMID:bio_10.1101_2024.09.02.610852].

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1997 High

    Identification of UbcH5/UBE2D as the E2 enzyme supporting MDM2-mediated ubiquitination of p53 established UBE2D1 as a key conjugating enzyme in tumor suppressor regulation.

    Evidence In vitro ubiquitination reconstitution with purified E1, UbcH5, and MDM2; active-site cysteine mutagenesis

    PMID:9450543

    Open questions at the time
    • Specificity among UBE2D paralogs (UBE2D1 vs D2 vs D3) for MDM2 not resolved
    • Cellular validation of paralog contribution lacking
  2. 2000 High

    Demonstration that the VHL–Elongin B/C–Cullin-2–Rbx1 complex uses UBE2D family enzymes to ubiquitinate HIF1α revealed the biochemical basis of oxygen-dependent HIF1α degradation and expanded UBE2D's E3 partner repertoire to CRL complexes.

    Evidence In vitro ubiquitination reconstitution with purified recombinant VHL complex components

    PMID:10973499

    Open questions at the time
    • Relative contribution of UBE2D1 versus other E2s in HIF1α turnover in vivo not determined
    • Chain-linkage specificity not characterized in this context
  3. 2001 High

    Three independent studies in the same year showed UBE2D family as the E2 for BRCA1-BARD1, CHIP, and Siah-1 E3 ligases, establishing UBE2D as a broadly promiscuous conjugating enzyme paired with structurally diverse E3 architectures (RING heterodimer, U-box, RING/F-box).

    Evidence In vitro ubiquitination assays with recombinant proteins; co-immunoprecipitation; U-box and RING mutagenesis; β-catenin degradation assays

    PMID:11278247 PMID:11389839 PMID:11557750

    Open questions at the time
    • Structural basis for promiscuous E3 recognition by UBE2D not yet resolved
    • Whether UBE2D1 specifically or multiple paralogs participate in each pathway in vivo is unclear
  4. 2002 High

    Clarification that the previously reported 'SFT' (Stimulator of Fe Transport) cDNA was actually an intronic fragment of UBE2D1 resolved a gene identity confusion and eliminated a spurious iron-transport function.

    Evidence Sequence analysis of 5' regulatory region; RT-PCR in HepG2 cells

    PMID:12480712

    Open questions at the time
    • No remaining gap from this correction per se
  5. 2003 High

    Discovery that MDM2 concentration dictates whether UBE2D-supported ubiquitination of p53 produces mono- or polyubiquitin conjugates—and that monoubiquitination suffices for nuclear export—revealed UBE2D's role in p53 trafficking decisions, not just degradation.

    Evidence In vitro ubiquitination titration; p53-ubiquitin fusion constructs; cell fractionation and nuclear export assays

    PMID:14671306

    Open questions at the time
    • Whether UBE2D1 contributes uniquely versus other family members in setting the mono/poly switch is unknown
    • In vivo quantification of MDM2 threshold levels not established
  6. 2004 High

    Identification of UBE2D as the E2 for both SCF-Fbw7-mediated c-Myc ubiquitination and A20-mediated K48-linked ubiquitination of RIP1 extended UBE2D's functional scope to Wnt/Myc and NF-κB pathway regulation, and revealed its capacity to support both K48 and K63 linkage types depending on E3 context.

    Evidence In vitro ubiquitination reconstitution; RNAi and KO validation (Fbw7); A20 domain mutagenesis and A20-deficient mouse cells

    PMID:15103331 PMID:15258597

    Open questions at the time
    • Mechanism by which the same E2 produces different chain types with different E3s not structurally resolved
    • Relative physiological contribution versus UbcH13/Uev1A for K63 chains in NF-κB signaling unclear
  7. 2008 High

    Reconstitution of RNF4-mediated ubiquitination of poly-SUMO-modified PML using UBE2D as E2 established UBE2D1 as a key enzyme at the SUMO–ubiquitin interface, linking it to arsenic-induced PML degradation in acute promyelocytic leukemia therapy.

    Evidence In vitro ubiquitination with SUMO-modified PML substrates; RNF4 depletion by RNAi; arsenic treatment

    PMID:18408734

    Open questions at the time
    • Whether UBE2D1 or another paralog is rate-limiting in vivo for RNF4 activity not tested
    • No structural model of the RNF4–UBE2D–SUMO-chain ternary complex
  8. 2010 High

    Discovery that sphingosine-1-phosphate acts as a cofactor for TRAF2 E3 ligase activity with UBE2D1 as E2 for K63-linked RIP1 ubiquitination integrated lipid signaling with ubiquitin conjugation and revealed a metabolite-gated mechanism for UBE2D1 function.

    Evidence In vitro ubiquitination reconstitution with purified TRAF2 and UbcH5a/UBE2D1; lipid binding assays; NF-κB activation assays

    PMID:20577214

    Open questions at the time
    • Whether S1P similarly modulates other TRAF-family E3s with UBE2D1 is untested
    • Structural mechanism of S1P-dependent RING domain activation not resolved
  9. 2024 Medium

    Elucidation of how TCF25 imposes K48-linkage specificity on the UBE2D1~Ub conjugate during Listerin-mediated ribosome-associated quality control provided the first mechanistic explanation for how an extrinsic factor can redirect UBE2D1's intrinsically promiscuous chain-type output.

    Evidence In vitro ubiquitination assays with linkage-specificity analysis; AlphaFold3 structural modeling; site-directed mutagenesis (preprint)

    PMID:bio_10.1101_2024.10.17.618946

    Open questions at the time
    • Structural model relies partly on AlphaFold3 prediction rather than experimental structure
    • In vivo validation of TCF25-imposed specificity on endogenous stalled ribosomes not shown
    • Whether other cofactors similarly redirect UBE2D chain specificity is unknown
  10. 2024 Medium

    Development of a selective multivalent UBE2D inhibitor that phenocopies knockdown in cells—increasing ~20% of the proteome and sensitizing cells to cisplatin—demonstrated UBE2D's outsized role in global proteostasis and provided a chemical biology tool for family-level inhibition.

    Evidence Engineered protein inhibitor design; whole-cell quantitative proteomics; cisplatin sensitivity assay; siRNA comparison (preprint)

    PMID:bio_10.1101_2024.09.02.610852

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Individual contributions of UBE2D1, D2, D3, and D4 paralogs to the proteome-wide effect not deconvoluted
    • Long-term cellular consequences and in vivo applicability of the inhibitor not explored

Open questions

Synthesis pass · forward-looking unresolved questions
  • A comprehensive structural and selectivity framework explaining how UBE2D1 achieves promiscuous E3 pairing while maintaining context-dependent chain-type specificity remains unresolved, as does delineation of non-redundant functions among UBE2D paralogs in vivo.
  • No systematic paralog-specific genetic analysis in mammalian models
  • No high-resolution ternary structures of UBE2D1 with diverse E3s and substrates
  • Tissue-specific or developmental roles of UBE2D1 versus other paralogs not characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 9 GO:0016874 ligase activity 7
Localization
GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-392499 Metabolism of proteins 9 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2 R-HSA-5357801 Programmed Cell Death 2
Partners
A20BRCA1CHIPLTN1MDM2RNF4TRAF2VHL

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 MDM2 oncoprotein functions as a ubiquitin ligase (E3) that polyubiquitinates tumor suppressor p53 in the presence of E1 and UbcH5 (UBE2D family) as the E2 ubiquitin-conjugating enzyme, with MDM2 forming a sulfhydryl bond with ubiquitin through a cysteine in its C-terminus essential for activity. In vitro ubiquitination reconstitution assay with purified E1, UbcH5/UBE2D as E2, and MDM2 as E3; active-site cysteine mutagenesis FEBS letters High 9450543
2000 A reconstituted VHL tumor suppressor complex (containing Elongin B/C, Cullin-2, and Rbx1) functions as an E3 ubiquitin ligase that activates ubiquitination of HIF1α in vitro in the presence of E1 and E2 ubiquitin-conjugating enzyme (UBE2D/UbcH5 family), establishing the biochemical mechanism by which VHL targets HIF1α for proteasomal degradation under normoxic conditions. In vitro ubiquitination reconstitution with purified recombinant VHL complex, E1, and E2 (UbcH5 family); biochemical assay Proceedings of the National Academy of Sciences of the United States of America High 10973499
2001 The BRCA1-BARD1 heterodimeric RING finger complex exhibits ubiquitin ligase activity that requires both subunits; individually each has low activity but together they dramatically increase polyubiquitin chain formation using UBCH5 (UBE2D family) as E2, and this activity is disrupted by a breast cancer-derived RING finger mutation (C61G) in BRCA1. In vitro ubiquitination assay with bacterially purified RING finger domains; active-site mutagenesis; co-transfection stability assays The Journal of biological chemistry High 11278247
2001 CHIP (carboxyl terminus of Hsc70-interacting protein) is a U-box-dependent E3 ubiquitin ligase that interacts functionally and physically with the UBCH5 (UBE2D) family of stress-responsive ubiquitin-conjugating enzymes; CHIP promotes ubiquitylation of chaperone substrates and ubiquitinates Hsc70 itself with short, noncanonical multiubiquitin chains. In vitro ubiquitylation assay with recombinant proteins; co-immunoprecipitation; U-box mutagenesis The Journal of biological chemistry High 11557750
2001 Siah-1 (mammalian homolog of Drosophila Sina) physically binds ubiquitin-conjugating enzymes (UbcH5/UBE2D family) and, together with SIP and the F-box protein Ebi, forms a novel ubiquitin ligase complex that mediates β-catenin degradation downstream of p53, linking genotoxic stress to reduction of Tcf/LEF transcriptional activity. Co-immunoprecipitation; in vitro binding assays; β-catenin degradation assays in cells; genetic epistasis via p53 induction Molecular cell High 11389839
2002 The previously characterized 'SFT' (Stimulator of Fe Transport) cDNA sequence corresponds to intron 6/exon 7 of UbcH5A (UBE2D1), a member of the E2 ubiquitin-conjugating enzyme family involved in iron-dependent ubiquitination of HIF1α by the VHL E3 ligase complex; the two are not separate proteins and the originally proposed iron transport function of 'SFT' was based on a truncated/intronic sequence. Sequence analysis of 5' regulatory region; sequence-specific RT-PCR; in vitro studies in HepG2 cells Blood High 12480712
2003 Low levels of Mdm2 activity induce monoubiquitination and nuclear export of p53, whereas high Mdm2 levels promote polyubiquitination and nuclear degradation of p53; UbcH5/UBE2D family serves as E2 in this differential ubiquitination, and a p53-ubiquitin fusion mimicking monoubiquitinated p53 accumulates in the cytoplasm in an Mdm2-independent manner, demonstrating that monoubiquitination per se drives p53 trafficking. In vitro ubiquitination reconstitution; p53-ubiquitin fusion protein; cell fractionation and nuclear export assays Science (New York, N.Y.) High 14671306
2004 The F-box protein Fbw7 interacts with and destabilizes c-Myc in a phosphorylation-dependent manner (requiring Thr58/Ser62 phosphorylation in MB1); UbcH5/UBE2D family serves as E2 in this SCF-Fbw7-mediated ubiquitylation, and depletion of Fbw7 by RNAi increases c-Myc abundance and transactivation activity. Co-immunoprecipitation; in vitro ubiquitylation assay; RNAi knockdown; Fbw7 knockout ES cells The EMBO journal High 15103331
2004 A20 downregulates NF-κB signaling through two sequential ubiquitin-editing activities: its OTU-domain removes K63-linked ubiquitin chains from RIP1, while its C-terminal zinc finger domain functions as a ubiquitin ligase (using UbcH5/UBE2D as E2) to polyubiquitinate RIP1 with K48-linked chains, targeting RIP1 for proteasomal degradation. In vitro deubiquitination and ubiquitination assays; domain mutagenesis; cell-based NF-κB reporter assays; A20-deficient mouse cells Nature High 15258597
2008 RNF4, a RING-domain E3 ubiquitin ligase, targets poly-SUMO-modified PML for K48-linked polyubiquitination and proteasomal degradation (arsenic-induced PML degradation in APL); UbcH5/UBE2D family serves as the E2 partner, and in vitro reconstitution demonstrated SUMO-dependent ubiquitination of PML by RNF4. In vitro ubiquitination reconstitution with SUMO-modified substrates; RNF4 depletion by RNAi; arsenic treatment; cell fractionation Nature cell biology High 18408734
2010 Sphingosine-1-phosphate (S1P) is a required cofactor for TRAF2 E3 ubiquitin ligase activity; S1P binds to the RING domain of TRAF2 and stimulates K63-linked polyubiquitination of RIP1 in vitro in the presence of UbcH5a (UBE2D1) or UbcH13 as E2, revealing UBE2D1 as a functional E2 partner for TRAF2 in TNF-α/NF-κB signaling. In vitro ubiquitination reconstitution with purified recombinant TRAF2, UbcH5a/UBE2D1, RIP1; lipid binding assays; cell-based NF-κB activation assays Nature High 20577214
2024 TCF25 (Rqc1 in yeast) imposes K48-linkage specificity on Listerin-mediated ubiquitination of nascent chains by specifically binding both the RING domain of Listerin and the acceptor ubiquitin (UbA), orienting UbA so that its K48 directly attacks the thioester bond of the Ube2D1~Ub conjugate; TCF25 itself undergoes K48-specific ubiquitination by Listerin, suggesting a self-regulatory mechanism. Functional biochemical studies (in vitro ubiquitination assays); AlphaFold3 structural modeling; linkage-specificity analysis; site-directed mutagenesis bioRxivpreprint Medium bio_10.1101_2024.10.17.618946
2024 A highly selective, multivalent engineered protein inhibitor targeting both the RING-binding and backside-binding sites of the UBE2D (UbcH5) family simultaneously was developed; in HeLa cells, these inhibitors phenocopy UBE2D knockdown by reducing cisplatin IC50 and whole-cell proteomics revealed increased abundance of ~20% of identified proteins, consistent with reduced ubiquitin-mediated degradation and proteotoxic stress, establishing UBE2D's central role in proteome management. Engineered multivalent protein inhibitor design; cell-based viability assay (cisplatin sensitivity); whole-cell quantitative proteomics; siRNA knockdown comparison bioRxivpreprint Medium bio_10.1101_2024.09.02.610852

Source papers

Stage 0 corpus · 68 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2010 Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature genetics 2036 21102463
1997 Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS letters 1655 9450543
2004 Bone morphogenetic proteins. Growth factors (Chur, Switzerland) 1639 15621726
2004 De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 1560 15258597
2013 Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science (New York, N.Y.) 1480 24292625
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2007 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 1420 17392790
2004 Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Molecular and cellular biology 1052 15572695
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2014 Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 858 25043012
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2009 A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 843 19490893
2001 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. The Journal of cell biology 726 11535616
2004 Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. The EMBO journal 712 15103331
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2008 RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nature cell biology 695 18408734
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2006 A ubiquitin ligase complex assembles linear polyubiquitin chains. The EMBO journal 643 17006537
2003 Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (New York, N.Y.) 642 14671306
2010 Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 632 20577214
2003 Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Molecular cell 573 14690596
2001 The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. The Journal of biological chemistry 555 11278247
2000 Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proceedings of the National Academy of Sciences of the United States of America 546 10973499
2016 A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature 522 27338790
2001 Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Molecular cell 522 11389839
2001 CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. The Journal of biological chemistry 497 11557750
2016 Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase. Nature 479 26909574
2004 A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 469 14980219
2009 Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT? The American journal of surgical pathology 200 19718788
2010 Over-expression of sly-miR156a in tomato results in multiple vegetative and reproductive trait alterations and partial phenocopy of the sft mutant. FEBS letters 132 21187095
2012 Sunitinib malate in solitary fibrous tumor (SFT). Annals of oncology : official journal of the European Society for Medical Oncology 124 22711763
1997 Functional expression cloning and characterization of SFT, a stimulator of Fe transport. The Journal of cell biology 79 9362508
2020 miR156a-targeted SBP-Box transcription factor SlSPL13 regulates inflorescence morphogenesis by directly activating SFT in tomato. Plant biotechnology journal 71 31916387
2018 SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization. The Journal of cell biology 51 29643117
2008 Primary solitary fibrous tumor (SFT) in the retroperitoneum. Urologic oncology 41 18452815
2012 Crystal structure of 6-SST/6-SFT from Pachysandra terminalis, a plant fructan biosynthesizing enzyme in complex with its acceptor substrate 6-kestose. The Plant journal : for cell and molecular biology 38 22098191
2010 Unexpected presence of graminan- and levan-type fructans in the evergreen frost-hardy eudicot Pachysandra terminalis (Buxaceae): purification, cloning, and functional analysis of a 6-SST/6-SFT enzyme. Plant physiology 38 21037113
2004 Distinct regulation of sucrose: sucrose-1-fructosyltransferase (1-SST) and sucrose: fructan-6-fructosyltransferase (6-SFT), the key enzymes of fructan synthesis in barley leaves: 1-SST as the pacemaker. The New phytologist 35 33873712
1998 Influence of copper depletion on iron uptake mediated by SFT, a stimulator of Fe transport. The Journal of biological chemistry 31 9506995
2018 Indications for islet or pancreatic transplantation: Statement of the TREPID working group on behalf of the Société francophone du diabète (SFD), Société francaise d'endocrinologie (SFE), Société francophone de transplantation (SFT) and Société française de néphrologie - dialyse - transplantation (SFNDT). Diabetes & metabolism 29 30223084
2010 Towards a better understanding of the generation of fructan structure diversity in plants: molecular and functional characterization of a sucrose:fructan 6-fructosyltransferase (6-SFT) cDNA from perennial ryegrass (Lolium perenne). Journal of experimental botany 27 21196473
1998 Structural and functional analysis of SFT, a stimulator of Fe Transport. The Journal of biological chemistry 23 9694900
2017 Validation of nuclear STAT6 immunostaining as a diagnostic marker of meningeal solitary fibrous tumor (SFT)/hemangiopericytoma. Clinical neuropathology 21 28128724
2004 Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. Journal of neuroscience research 21 15139022
1998 Expression of SFT (stimulator of Fe transport) is enhanced by iron chelation in HeLa cells and by hemochromatosis in liver. The Journal of biological chemistry 21 9856986
2015 Identification and development of a functional marker from 6-SFT-A2 associated with grain weight in wheat. Molecular breeding : new strategies in plant improvement 20 25653572
2002 Transferrin receptor 1 (TfR1) and putative stimulator of Fe transport (SFT) expression in iron deficiency and overload: an overview. Blood cells, molecules & diseases 20 12547240
2013 Targeted therapies in rare sarcomas: IMT, ASPS, SFT, PEComa, and CCS. Hematology/oncology clinics of North America 16 24093175
2009 Molecular characterization of a putative sucrose:fructan 6-fructosyltransferase (6-SFT) of the cold-resistant Patagonian grass Bromus pictus associated with fructan accumulation under low temperatures. Plant & cell physiology 15 19153157
2005 Mutational analysis of the active center of plant fructosyltransferases: Festuca 1-SST and barley 6-SFT. FEBS letters 15 16098522
2002 UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis. Blood 14 12480712
2018 Imbalanced Expression of IGF2 and PCSK4 Is Associated With Overproduction of Big IGF2 in SFT With NICTH: A Pilot Study. The Journal of clinical endocrinology and metabolism 13 29897468
1998 Characterization and chromosomal mapping of the human gene for SFT, a stimulator of Fe transport. Biochemical and biophysical research communications 13 9918797
2024 Strigolactones promote flowering by inducing the miR319-LA-SFT module in tomato. Proceedings of the National Academy of Sciences of the United States of America 10 38701118
2000 Linkage mapping and nucleotide polymorphisms of the 6-SFT gene of cool-season grasses. Genome 9 11195345
2015 A sucrose:fructan-6-fructosyltransferase (6-SFT) gene from Psathyrostachys huashanica confers abiotic stress tolerance in tobacco. Gene 8 26072162
2012 Carbohydrate profiling in seeds and seedlings of transgenic triticale modified in the expression of sucrose:sucrose-1-fructosyltransferase (1-SST) and sucrose:fructan-6-fructosyltransferase (6-SFT). Journal of bioscience and bioengineering 6 22698728
2020 [Physiological and Psychological Data influencing Pregnant Women Smoking Behavior - CNGOF-SFT Expert Report and Guidelines for Smoking Management during Pregnancy]. Gynecologie, obstetrique, fertilite & senologie 5 32247097
2013 The SFT-1 and OXA-1 respiratory chain complex assembly factors influence lifespan by distinct mechanisms in C. elegans. Longevity & healthspan 5 24472117
2020 Perigastric solitary fibrous tumor (SFT) diagnosed on fine needle aspiration: A case report and review of literature. Diagnostic cytopathology 4 32628336
2008 [Solitary fibrous tumour of the testes (SFT)]. Aktuelle Urologie 4 18663673
2010 Molecular characterization of RNA and protein synthesis during a one-step growth curve of bovine viral diarrhoea virus in ovine (SFT-R) cells. Research in veterinary science 3 20116078
2023 Large Solitary Fibrous Tumor (SFT) of the penis- a case report and review of literature. BMC urology 2 37533000
2025 Identification of BET Inhibitors (BETi) Against Solitary Fibrous Tumor (SFT) Through High-Throughput Screening (HTS). bioRxiv : the preprint server for biology 0 40196499
2025 Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS). Neoplasia (New York, N.Y.) 0 41166819
2019 6-SFT, a Protein from Leymus mollis, Positively Regulates Salinity Tolerance and Enhances Fructan Levels in Arabidopsis thaliana. International journal of molecular sciences 0 31159261