Affinage

STOM

Stomatin · UniProt P27105

Round 2 corrected
Length
288 aa
Mass
31.7 kDa
Annotated
2026-04-28
102 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Stomatin (STOM) is a monotopic integral membrane protein of the SPFH/prohibitin superfamily that assembles into oligomeric complexes within lipid raft microdomains to regulate the activity of diverse ion channels, transporters, and membrane trafficking events. STOM inhibits ASIC3 by stabilizing its desensitized state through interactions at the distal C-terminus and TM1 (PMID:32012213), inhibits GLUT1-mediated glucose transport in a manner relieved by PON2 (PMID:33531346), and promotes Pannexin 1 pore opening in red blood cells (PMID:36012667). Beyond channel regulation, STOM partners with DRAM to promote lysosomal membrane permeabilization and exosome secretion (PMID:34731006), and drives osteoclast differentiation by targeting Peroxiredoxin 1 (Prdx1) for lysosomal degradation, thereby elevating intracellular ROS (PMID:40595453). Loss of stomatin in overhydrated hereditary stomatocytosis (OHSt) erythrocytes is associated with reduced PANX1 channel activity (PMID:36012667).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1993 Medium

    Mapping STOM (EPB72) to chromosome 9q34.1 established its genomic identity and placed it among erythrocyte membrane gene clusters, enabling subsequent structural and functional studies.

    Evidence Southern blot analysis of somatic cell hybrid DNA panels

    PMID:8500356

    Open questions at the time
    • No functional characterization at this stage
    • Chromosomal assignment does not reveal protein function
  2. 1996 Medium

    Characterization of human and mouse stomatin gene structure revealed a conserved 7-exon, TATA-less housekeeping promoter architecture, explaining ubiquitous tissue expression but leaving open how tissue-specific functions arise.

    Evidence Genomic library screening, sequencing of exon-intron boundaries and 5'-flanking DNA in human and mouse

    PMID:8786142 PMID:8825639

    Open questions at the time
    • No functional assays to link promoter elements to expression regulation
    • Exon boundaries do not map to predicted structural domains
  3. 2002 Medium

    Identification of stomatin as a lipid raft/detergent-resistant membrane component co-isolating with fodrin and flotillins established its association with membrane microdomain–cytoskeleton interfaces, providing a physical framework for its regulatory roles.

    Evidence Sucrose gradient fractionation with Triton X-100 extraction, MALDI-TOF MS identification from bovine neutrophil plasma membranes

    PMID:12202484

    Open questions at the time
    • No direct demonstration of functional consequence of raft localization
    • Lipid raft association shown only in neutrophils
  4. 2011 Medium

    siRNA depletion of STOM increased intracellular Salmonella replication and disrupted microcolony architecture, revealing stomatin as a host restriction factor that maintains integrity of pathogen-containing compartments.

    Evidence SILAC proteomics of Golgi fractions, siRNA knockdown with bacterial replication and microscopy readouts in human epithelial cells

    PMID:21919203

    Open questions at the time
    • Mechanism of compartment integrity maintenance unknown
    • Not confirmed in animal infection models
  5. 2020 High

    Demonstration that STOM inhibits ASIC3 by stabilizing its desensitized state—requiring the distal C-terminus for complex formation and TM1 for regulatory effect—resolved the molecular mechanism of STOM-mediated ion channel modulation without altering surface expression or pH sensitivity.

    Evidence Chimeric channels, patch-clamp electrophysiology, FRET, site-directed mutagenesis including Q269G desensitization-defective mutant

    PMID:32012213

    Open questions at the time
    • Structural basis of the STOM–ASIC3 interface at atomic resolution unresolved
    • Whether STOM uses a similar desensitization-stabilization mechanism on other channels untested
  6. 2021 High

    Genetic epistasis showed STOM inhibits GLUT1-mediated glucose transport and that PON2 relieves this inhibition; STOM deletion rescued PON2-deficient B-ALL cells, ordering these proteins in a metabolic regulatory pathway.

    Evidence Genetic deletion of PON2 and STOM in mouse B-ALL models and patient-derived cells, glucose uptake and ATP assays

    PMID:33531346

    Open questions at the time
    • Direct physical interaction between STOM and GLUT1 not demonstrated
    • Mechanism by which STOM restrains GLUT1 activity not resolved
  7. 2021 High

    DRAM was identified as a stomatin partner that promotes its lysosomal localization, coupling fatty acid signaling to lysosomal membrane permeabilization and exosome secretion from hepatocytes—expanding STOM function beyond channel regulation to vesicular trafficking.

    Evidence Co-immunoprecipitation, DRAM-knockout mouse and siRNA models, lysosomal fractionation, exosome isolation

    PMID:34731006

    Open questions at the time
    • How STOM mechanistically induces lysosomal membrane permeabilization is unresolved
    • Relevance to non-hepatic cell types not established
  8. 2022 Medium

    Multiple studies in 2022 expanded understanding: NMR structure of the SPFH domain revealed a phosphate-binding pocket that regulates oligomeric self-assembly; stomatin was shown to promote PANX1 pore opening in erythrocytes (reduced in OHSt patient cells lacking STOM); and STOML3 was found to be required for correct ciliary localization of STOM in olfactory sensory neurons.

    Evidence Solution NMR and electron microscopy of SPFH domain; PLA and dye-uptake assays in OHSt patient RBCs and STOM-KO K562 cells; immunofluorescence in STOML3-KO mouse olfactory epithelium

    PMID:35663930 PMID:35794236 PMID:36012667

    Open questions at the time
    • Phosphate-binding pocket's physiological ligand in vivo unidentified
    • Mechanism by which STOM promotes PANX1 opening (caspase-independent autoinhibition relief) remains hypothetical
    • Whether STOML3-dependent ciliary targeting of STOM is required for olfactory signaling not tested
  9. 2022 Medium

    STOM was identified as a cell-surface receptor for H. pylori VacA, mediating endosomal entry and subsequent mitochondrial targeting that triggers PINK1/Parkin-dependent mitophagy, linking stomatin to pathogen-induced organelle quality control.

    Evidence LC-MS/MS pull-down, co-immunoprecipitation, fluorescence microscopy of endosome formation and mitochondrial depolarization

    PMID:35912184

    Open questions at the time
    • Single lab study; VacA–STOM interaction domain not mapped
    • Whether STOM is necessary and sufficient for VacA entry not tested by genetic complementation
  10. 2025 High

    STOM was established as a positive regulator of osteoclast differentiation in vivo: it interacts with Prdx1 and promotes its lysosomal degradation, elevating ROS to activate osteoclastogenic transcriptional programs. STOM-deficient mice showed higher bone mass, and macrophage-targeted STOM inhibition alleviated ovariectomy-induced bone loss.

    Evidence STOM-knockout mice, ovariectomy model, co-IP of STOM–Prdx1, lysosomal degradation assay, ROS measurement, in vivo macrophage-targeted inhibition

    PMID:40595453

    Open questions at the time
    • Structural basis of STOM–Prdx1 interaction not determined
    • Whether this Prdx1-degradation mechanism operates in other STOM-expressing cell types unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the atomic-resolution structure of full-length stomatin oligomers; how STOM selectively modulates distinct channels (ASIC3 inhibition vs. PANX1 activation) through a common SPFH scaffold; the physiological ligand of the SPFH phosphate-binding pocket; and whether STOM's lysosomal trafficking functions and channel-regulatory functions are mechanistically coupled.
  • No full-length stomatin structure available
  • Unifying model for opposing effects on different channels lacking
  • In vivo significance of phosphate-binding pocket untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0005198 structural molecule activity 1 GO:0008289 lipid binding 1
Localization
GO:0005886 plasma membrane 4 GO:0005764 lysosome 2 GO:0031410 cytoplasmic vesicle 2 GO:0005768 endosome 1 GO:0005929 cilium 1
Pathway
R-HSA-382551 Transport of small molecules 3 R-HSA-168256 Immune System 2 R-HSA-9612973 Autophagy 2 R-HSA-1266738 Developmental Biology 1 R-HSA-1430728 Metabolism 1 R-HSA-5653656 Vesicle-mediated transport 1
Partners
ASIC3CD36DRAMGLUT1PANX1PON2PRDX1STOML3

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 The human stomatin gene (EPB72) spans approximately 30 kb and comprises seven exons; its 5'-flanking region contains consensus sequences for ubiquitous transcription factors (Sp1, AP1, AP2, NF-κB, CREB, EKLF, GATA-1) but no TATA box, consistent with a housekeeping gene promoter, explaining its ubiquitous expression across cell types. Genomic library screening, Southern blotting, sequencing of exon-intron boundaries, promoter analysis Genomics Medium 8825639
1993 The EPB72 gene encoding human stomatin (erythrocyte band 7 integral membrane protein) was localized to chromosome band 9q34.1 by Southern blot analysis of somatic cell hybrid DNA panels, placing it in the same region as other erythrocyte membrane genes. Southern blot analysis of somatic cell hybrid DNA panels Cytogenetics and cell genetics Medium 8500356
1996 The murine stomatin gene (Epb72) is encoded by seven exons spanning approximately 25 kb; its 5'-flanking DNA has features of a TATA-less housekeeping gene promoter with binding sites for ubiquitous transcription factors, and exon boundaries do not correspond to the three predicted structural domains of the protein. Chromosomal gene cloning, genomic sequencing, 5'-flanking DNA characterization Genomics Medium 8786142
2002 Stomatin (STOM) was identified as a component of the detergent-resistant membrane skeleton (lipid raft fraction) co-isolating with high-density DRM fragments from bovine neutrophil plasma membranes, together with fodrin, myosin, flotillin 1, flotillin 2, and signaling proteins, placing stomatin at the intersection of lipid raft domains and the actin-based membrane skeleton. Differential centrifugation, sucrose density gradient fractionation, MALDI-TOF and tandem mass spectrometry, detergent extraction with Triton X-100 and sodium carbonate The Journal of biological chemistry Medium 12202484
2011 siRNA-mediated depletion of STOM in human epithelial cells increased Salmonella typhimurium replication and caused dispersal of intracellular Salmonella microcolonies, indicating that stomatin is a host factor that restricts intracellular bacterial growth and helps maintain the integrity of Salmonella-containing compartments. SILAC-based quantitative proteomics of Golgi-enriched fractions, siRNA knockdown, intracellular bacterial replication assay, fluorescence microscopy of microcolonies Proteomics Medium 21919203
2020 STOM inhibits ASIC3 channel activity by stabilizing the desensitized state of the channel. Using chimeric channels, patch-clamp electrophysiology, and FRET, two distinct sites on ASIC3 were identified as required for STOM regulation: the distal C-terminus (critical for STOM-ASIC3 complex formation) and the first transmembrane domain TM1 (required only for the regulatory effect). The ASIC3 point mutation Q269G, which prevents desensitization, also abolishes STOM regulation. STOM does not alter surface expression of ASIC3 or shift pH dependence of activation. Chimeric channel construction, patch-clamp electrophysiology, FRET, site-directed mutagenesis, surface expression assay The Journal of general physiology High 32012213
2021 Fatty acid-induced DRAM (damage-regulated autophagy modulator) interacts with stomatin (STOM) and promotes STOM's lysosomal localization, which in turn enhances lysosomal membrane permeabilization (LMP) and exosome secretion from hepatocytes. DRAM knockdown inhibited FA-induced LMP and decreased exosome release; lysosomal inhibitor reversed the reduction of exosome release in DRAM knockout mice. Knockout mouse model, siRNA knockdown, co-immunoprecipitation (DRAM-STOM interaction), lysosomal fractionation, exosome isolation and quantification, lysosomal membrane permeabilization assay Science advances High 34731006
2021 PON2 enables glucose uptake in B-cell acute lymphoblastic leukemia (B-ALL) by releasing the glucose transporter GLUT1 from inhibition by stomatin (STOM). Genetic deletion of STOM largely rescued PON2 deficiency in B-ALL cells, demonstrating that STOM acts as an inhibitor of GLUT1-mediated glucose transport and that PON2 functions by relieving this STOM-mediated inhibition. Genetic deletion of PON2 and STOM in mouse B-ALL models, glucose uptake assays, ATP production measurements, epistasis rescue experiments, patient-derived B-ALL cell assays Proceedings of the National Academy of Sciences of the United States of America High 33531346
2022 Stomatin interacts with Pannexin 1 (PANX1) in human red blood cells, as shown by Proximity Ligation Assay. RBCs from OverHydrated Hereditary Stomatocytosis (OHSt) patients lacking stomatin showed significantly reduced PANX1 channel activity (dye uptake reduced from ~34% to ~11.8% for carboxyfluorescein, and from ~35.7% to ~18.4% for TO-PRO-3 in stomatin-null K562 cells). Stomatin promotes PANX1 pore opening, possibly by caspase-independent lifting of autoinhibition. Proximity Ligation Assay with flow imaging, dye uptake assays (CF and TO-PRO-3) in OHSt patient RBCs and stomatin-knockout K562 erythroid cells International journal of molecular sciences Medium 36012667
2022 The solution NMR structure of the human stomatin SPFH domain (hSTOM-SPFH) was determined and found to be essentially identical to the previously reported mouse crystal structure, except for a small hydrophilic surface pocket identified as a phosphate-binding site. At elevated concentrations, hSTOM-SPFH forms a fibril-like self-assembly (visualized by electron microscopy), which is resistant to dissolution in phosphate buffer, suggesting that the phosphate-binding pocket regulates SPFH domain oligomerization. Solution NMR structure determination, NMR titration with phosphate ions, electron microscopy, centrifugal ultrafiltration-induced self-assembly Current research in structural biology Medium 35663930
2022 STOM and STOML3 are co-expressed in olfactory sensory neuron (OSN) cilia with a similar expression pattern; STOML3 is required for correct localization of STOM to OSN cilia, as STOM fails to properly localize to cilia in the absence of STOML3. Immunofluorescence in mouse olfactory epithelium, analysis of STOML3-knockout mice for STOM localization Scientific reports Medium 35794236
2022 The cell membrane protein STOM interacts with Helicobacter pylori vacuolating cytotoxin A (VacA); VacA captured by STOM forms endosomes to enter cells and target mitochondria, where it disrupts membrane potential and induces PINK1 accumulation and Parkin-dependent mitophagy. STOM was identified among 25 mitochondrial proteins bound to VacA by LC-MS/MS, and the STOM-VacA interaction was confirmed by co-immunoprecipitation. LC-MS/MS pull-down, co-immunoprecipitation, protein-protein docking, fluorescence microscopy of endosome formation and mitochondrial depolarization Frontiers in oncology Medium 35912184
2021 STOM-knockdown in LPS-treated mouse lung epithelial cells (MLE-12) reduced oxidative stress and inflammation. STOM was found to interact with CD36 by RNA immunoprecipitation, and STOM positively regulated CD36 expression; overexpression of CD36 reversed the protective effects of STOM knockdown, placing STOM upstream of CD36 in an LPS-induced inflammatory pathway. siRNA knockdown, CD36 overexpression, RNA immunoprecipitation (RIP) assay, CCK-8 cell viability, ELISA for inflammatory cytokines, Western blotting Experimental and therapeutic medicine Medium 34934440
2025 STOM is a positive regulator of osteoclast differentiation. STOM-deficient mice exhibit higher bone mass under normal conditions and after ovariectomy. Mechanistically, STOM interacts with Peroxiredoxin 1 (Prdx1) and promotes its degradation through the lysosomal pathway, thereby increasing intracellular ROS production and activating ROS-mediated transcriptional pathways that drive osteoclastogenesis. Targeted inhibition of macrophage STOM in mice alleviates ovariectomy-induced bone loss. STOM-knockout mice, ovariectomy model, transcriptomics, co-immunoprecipitation (STOM-Prdx1), lysosomal degradation assay, ROS measurement, osteoclast differentiation assay, targeted macrophage STOM inhibition in vivo Nature communications High 40595453

Source papers

Stage 0 corpus · 102 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 3411 32353859
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
2020 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 564 33060197
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2010 Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (New York, N.Y.) 421 20360068
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2011 Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 405 22020285
2011 Global identification of modular cullin-RING ligase substrates. Cell 354 21963094
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2012 Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature 319 22810586
2016 Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell reports 306 27342126
2009 Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 284 19190083
2018 Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. Cell reports 274 30110629
2010 Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Molecular & cellular proteomics : MCP 262 21139048
2002 Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. The Journal of biological chemistry 249 12202484
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2009 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science signaling 207 19738201
2002 Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle. Molecular and cellular biology 105 11739726
2019 Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers. Arthritis research & therapy 88 31366407
2005 Differentially expressed transcripts from phenotypically identified olfactory sensory neurons. The Journal of comparative neurology 76 15682396
2008 A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. PLoS genetics 70 18648537
2003 Regulation of maternal transcript destabilization during egg activation in Drosophila. Genetics 65 12871909
2002 Identification and characterization of a novel ABCA subfamily member, ABCA12, located in the lamellar ichthyosis region on 2q34. Cytogenetic and genome research 60 12697999
2009 Prevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in questing Ixodes ricinus ticks in relation to the density of wild cervids. Acta veterinaria Scandinavica 58 19943915
1989 Na+ and Cl- transport across rabbit nonciliated bronchiolar epithelial (Clara) cells. The American journal of physiology 41 2705518
2019 Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway. International journal of molecular sciences 40 31311100
2021 Lipid-induced DRAM recruits STOM to lysosomes and induces LMP to promote exosome release from hepatocytes in NAFLD. Science advances 36 34731006
1998 Permeation and pathways of human calcitonin (hCT) across excised bovine nasal mucosa. Peptides 36 9533651
2014 Simultaneous expression of flotillin-1, flotillin-2, stomatin and caveolin-1 in non-small cell lung cancer and soft tissue sarcomas. BMC cancer 33 24533441
2023 Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer's Disease. Journal of Alzheimer's disease : JAD 30 36776048
2018 Transcriptional control of O6 -methylguanine DNA methyltransferase expression and temozolomide resistance in glioblastoma. Journal of neurochemistry 30 29480969
2020 Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 28 32439797
2001 Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Cancer research 26 11221845
1978 Pathways for movement of ions and water across toad urinary bladder. III. Physiologic significance of the paracellular pathway. The Journal of membrane biology 26 564969
1995 The organization of the gene (EPB72) encoding the human erythrocyte band 7 integral membrane protein (protein 7.2b). Genomics 25 8825639
2018 Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma. Clinical epigenetics 24 30348215
2020 Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin. The Journal of general physiology 23 32012213
2010 Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. American journal of medical genetics. Part A 23 20583170
2001 A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1. Cytogenetics and cell genetics 22 11435687
2011 Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle. Proteomics 21 21919203
2018 Isotopic labeling with cellular O-glycome reporter/amplification (ICORA) for comparative O-glycomics of cultured cells. Glycobiology 20 29390058
2020 Amentoflavone induces cell cycle arrest, apoptosis, and autophagy in BV-2 cells. Frontiers in bioscience (Landmark edition) 16 31585918
2021 PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis. Proceedings of the National Academy of Sciences of the United States of America 15 33531346
2021 Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer. Bioactive materials 14 34938908
2021 Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA. Cells 14 34943861
2020 HY5 is not integral to light mediated stomatal development in Arabidopsis. PloS one 14 31945058
2014 Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood. PloS one 14 25379667
1994 Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9q. Genomics 14 8088777
2023 Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy. Nature communications 13 37919278
1990 Chemotactic peptide effects on intestinal electrolyte transport. The American journal of physiology 13 1701975
2018 Effects of downregulated expression of microRNA-187 in gastric cancer. Experimental and therapeutic medicine 12 30112051
2024 Modifiable lifestyle factors influencing psychiatric disorders mediated by plasma proteins: A systemic Mendelian randomization study. Journal of affective disorders 11 38246286
2022 Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells. Frontiers in oncology 11 35912184
2022 iTRAQ-based quantitative proteomics reveals biomarkers/pathways in psoriasis that can predict the efficacy of methotrexate. Journal of the European Academy of Dermatology and Venereology : JEADV 10 35666151
2023 Expression and Clinical Significance of PIEZO2 in Gastric Cancer. Combinatorial chemistry & high throughput screening 9 36757044
2021 Stomatin-knockdown effectively attenuates sepsis-induced oxidative stress and inflammation of alveolar epithelial cells by regulating CD36. Experimental and therapeutic medicine 9 34934440
2022 RNA modification-related variants in genomic loci associated with body mass index. Human genomics 8 35879730
2021 Convergence of biomarkers and risk factor trait loci of coronary artery disease at 3p21.31 and HLA region. NPJ genomic medicine 8 33574266
2006 Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure. Proteins 8 16671055
1993 The gene coding for erythrocyte protein band 7.2b (EPB72) is located in band q34.1 of human chromosome 9. Cytogenetics and cell genetics 8 8500356
2023 Proteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands. Clinical proteomics 7 36949424
2022 Expression pattern of Stomatin-domain proteins in the peripheral olfactory system. Scientific reports 7 35794236
2012 Effects of Locally and Systemically Applied n-3 Fatty Acid on Oral Ulcer Recovery Process in Rats. Wounds : a compendium of clinical research and practice 7 25874706
2023 Identification of new co-diagnostic genes for sepsis and metabolic syndrome using single-cell data analysis and machine learning algorithms. Frontiers in genetics 6 37007944
2023 Lysosome-Related Diagnostic Biomarkers for Pediatric Sepsis Integrated by Machine Learning. Journal of inflammation research 6 38034045
2023 The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation. Anaerobe 5 37541484
2004 [Identification of acute leukemia-specific genes from leukemia recipient/sibling donor pairs by distinguishing study with oligonucleotide microarrays]. Zhongguo shi yan xue ye xue za zhi 5 15363129
2000 A novel gene STORP (STOmatin-Related Protein) is localized 2 kb upstream of the promyelocytic gene on chromosome 15q22. European journal of haematology 5 10997330
1996 Genomic organization and 5'-flanking DNA sequence of the murine stomatin gene (Epb72). Genomics 5 8786142
1993 Bile salts and ileal calcium transport in rats: a neglected factor in intestinal calcium absorption. The American journal of physiology 5 8447415
2024 Halomarina litorea sp. nov., Halomarina pelagica sp. nov., Halomarina halobia sp. nov., and Halomarina ordinaria sp. nov., Halophilic Archaea Isolated from Coastal and Inland Saline Soil. Current microbiology 4 38806737
2022 A cryptic phosphate-binding pocket on the SPFH domain of human stomatin that regulates a novel fibril-like self-assembly. Current research in structural biology 4 35663930
2022 Mechanosensitive Pannexin 1 Activity Is Modulated by Stomatin in Human Red Blood Cells. International journal of molecular sciences 4 36012667
2025 Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models. Nature communications 3 40595453
2024 Predictive Value of a Diagnostic Five-Gene Biomarker for Pediatric Sepsis. Journal of inflammation research 3 38595339
2023 Morphological and molecular characterization of Stomachicola muraenesocis Yamaguti, 1934 (Digenea: Hemiuridae) from the daggertooth pike conger Muraenesox cinereus (Forsskål). Parasitology 3 37953070
2021 Proteomic analysis of human frontal and temporal cortex using iTRAQ-based 2D LC-MS/MS. Chinese neurosurgical journal 3 33952343
2025 Fungal resistance in rice is restored by interfamily transfer of an evolutionarily lost co-receptor. Cell host & microbe 2 40967211
2024 Tumor-derived mesenchymal progenitor cell-related genes in the regulation of breast cancer proliferation. Gland surgery 2 38601284
2024 Prediction and verification of benignancy and malignancy of pulmonary nodules based on inflammatory related biological markers. Heliyon 2 39144966
2023 Novel ratio-expressions of genes enables estimation of wound age in contused skeletal muscle. International journal of legal medicine 2 37804331
2024 [Transcriptome data mining combined with clinical and animal experiments for identification of syndrome element marker genes during entire course of steroid-induced osteonecrosis of femoral head]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 1 38621982
1975 Studies on the structure of beta-chitin, I. Zeitschrift fur Naturforschung. Section C, Biosciences 1 129986
2025 Exploring susceptibility and therapeutic targets for kidney stones through proteome-wide Mendelian randomization. Human molecular genetics 0 39530187
2025 Data-independent acquisition-based quantitative proteomic analysis of the effects of environmental enrichment on the dorsal roots of mice with neuropathic pain induced by chronic sciatic nerve constriction injury. Neuropharmacology 0 40288603
2025 Stomatin and Stomatin-Like Proteins Can Regulate Transporter Proteins Activity and Has a Role in Cancer Metastasis. The Journal of membrane biology 0 40637896
2025 Hypertension-related genes STOM, MEF2C promote proliferation and migration of clear cell renal cell carcinoma. Experimental cell research 0 40744318
2025 Identification and Validation of Mitochondria-Related Genes for Diagnosis of Early-Stage Sepsis. Annals of clinical and laboratory science 0 40962454
2025 Immunophenotype-mediated effects of plasma proteins on major depressive disorder: A two-step Mendelian randomization study. European archives of psychiatry and clinical neuroscience 0 41231246