Affinage

PANX1

Pannexin-1 · UniProt Q96RD7

Length
426 aa
Mass
48.0 kDa
Annotated
2026-06-10
100 papers in source corpus 30 papers cited in narrative 30 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PANX1 is a large-pore plasma membrane channel that mediates regulated release of ATP, coupling diverse cellular stimuli to purinergic signaling across the nervous, immune, metabolic, and reproductive systems (PMID:23449592, PMID:39709529, PMID:38957990). Cryo-EM defines the structural basis of its permeation: an extracellular constriction formed by seven W74 residues samples conformations ranging from a chloride-only state to a dilated, ATP-permeant state, with cation-π interactions between W74 and R75 controlling selectivity and the antimalarial mefloquine acting as a positive modulator (PMID:41381453). Channel gating is further controlled by an intracellular regulatory cysteine (C346), whose mutation produces a constitutively leaky, cytotoxic channel (PMID:20829356). PANX1 is activated through multiple convergent routes—physical and functional coupling to the P2X7 receptor (PMID:28430869, PMID:38100403), Src kinase downstream of non-ionotropic NMDA receptors (PMID:39709529), and caspase-dependent cleavage (caspase-1, caspase-5, caspase-8/3, and an N-terminal truncation that yields a constitutively active fragment) (PMID:35473933, PMID:38195677, PMID:40087867)—and the released ATP signals onward to purinergic receptors including P2RY12, P2X4, and P2X7 (PMID:34489419, PMID:39709529, PMID:38195677). Through this ATP-release function PANX1 drives neuroinflammation in cortical spreading depression via a caspase-1/HMGB1 cascade (PMID:23449592), hippocampal LTP and LTD underlying spatial memory (PMID:39709529, PMID:37365910), peripheral pain sensitization (PMID:38685116), cardiomyocyte metabolism and isoproterenol-induced hypertrophy (PMID:38957990), inflammasome-dependent injury responses (PMID:35473933, PMID:38336804), and tissue homeostasis in skin, bone, and the endometrium (PMID:24522432, PMID:27159053, PMID:41775813). Homozygous and dominant PANX1 variants that disrupt glycosylation and cause aberrant channel activation produce female infertility through oocyte death, and a loss-of-function variant causes a multisystem disorder with intellectual disability, sensorineural hearing loss, skeletal defects, and primary ovarian failure (PMID:27129271, PMID:33495594, PMID:39232764).

Mechanistic history

Synthesis pass · year-by-year structured walk · 30 steps
  1. 2008 High

    Established that PANX1 is not responsible for the P2X2 receptor dilated-permeability (I2) state, distinguishing intrinsic receptor conformational change from pannexin channel opening and constraining how PANX1 is invoked in purinergic permeability.

    Evidence Patch-clamp coordinated spectroscopy and conformational fluorophore assays with Panx1 knockdown

    PMID:18689682

    Open questions at the time
    • Does not address PANX1 coupling to other P2X subtypes
    • Negative result for one receptor only
  2. 2010 High

    Identified intracellular cysteine 346 as a critical gating residue, showing PANX1 channel opening is tightly regulated and that loss of this control produces a leaky, lethal channel.

    Evidence Site-directed mutagenesis with dye uptake and electrophysiology in Xenopus oocytes and N2A cells

    PMID:20829356

    Open questions at the time
    • Physiological modification controlling C346 not defined
    • No structural model of the closed state
  3. 2013 High

    Linked neuronal PANX1 megachannel opening to a defined neuroinflammatory cascade (caspase-1/HMGB1/NF-κB) driving headache, establishing PANX1 as an upstream trigger of trigeminovascular activation.

    Evidence In vivo pharmacological blockade and genetic suppression in a mouse cortical spreading depression model

    PMID:23449592

    Open questions at the time
    • Stimulus coupling PANX1 to caspase-1 not resolved at molecular level
  4. 2013 High

    Provided a selective small-molecule tool (BB FCF) distinguishing PANX1 from P2X7R pharmacologically, enabling clean dissection of PANX1-specific contributions.

    Evidence Dose-response electrophysiology and dye uptake in PANX1- vs P2X7R-expressing cells

    PMID:23589583

    Open questions at the time
    • In vivo selectivity and potency not established
  5. 2013 Medium

    Connected PANX1 to cytoskeletal machinery by demonstrating endogenous interaction with actin and Arp3 and roles in neural progenitor migration, hinting at channel-independent or cytoskeleton-coupled functions.

    Evidence Endogenous co-immunoprecipitation with scratch-wound and neurite assays under Panx1 knockdown

    PMID:23964896

    Open questions at the time
    • Direct vs indirect actin/Arp3 binding not resolved
    • Whether migration phenotype depends on channel activity unknown
  6. 2014 High

    Defined a homeostatic role for PANX1 in skin, regulating fibroblast contraction, myofibroblast differentiation, keratinocyte migration, and wound healing.

    Evidence Panx1 KO mice and probenecid blockade with proliferation, collagen contraction, and TGF-β assays

    PMID:24522432

    Open questions at the time
    • Downstream purinergic receptor in skin not identified
  7. 2016 High

    Identified a human loss-of-function PANX1 variant (R217H) causing a multisystem disorder, providing the first direct gene-disease link and showing the channel defect is recessive and trafficking-independent.

    Evidence Whole exome sequencing with dye uptake, ATP release, electrophysiology, and trafficking controls

    PMID:27129271

    Open questions at the time
    • Tissue-specific basis of each multisystem phenotype not dissected
  8. 2016 Medium

    Showed P2X7R-PANX1 co-expression mediates flow-induced ATP release in osteocyte mechanosignaling, extending PANX1 to bone and showing hyperglycemia blunts this pathway.

    Evidence Western blot co-expression, fluid shear stress, Ca2+ and ATP assays in a diabetic mouse model

    PMID:27159053

    Open questions at the time
    • Direct physical PANX1-P2X7 complex in osteocytes not shown
    • Single lab
  9. 2017 High

    Demonstrated PANX1 forms a functional pore complex with P2X7R that drives spreading depolarization and neuroinflammation, mechanistically linking the two channels.

    Evidence P2x7 knockout and pore-complex inhibitors in wild-type and familial hemiplegic migraine mutant mice

    PMID:28430869

    Open questions at the time
    • Stoichiometry and structural interface of the complex not defined
  10. 2017 Medium

    Excluded a cAMP-PANX1 pathway for ATP release from red blood cells, refining the contexts in which PANX1 mediates ATP efflux.

    Evidence Panx1-/- mice, exercise testing, RBC ATP release, and cAMP mass spectrometry with AC activators

    PMID:28855161

    Open questions at the time
    • Does not rule out PANX1 ATP release via other RBC stimuli
  11. 2019 Medium

    Mapped a C-terminal surface-targeting domain (307–379) and a YxxΦ sorting motif controlling apical PANX1 delivery and epithelial polarity, linking PANX1 trafficking to cell-cell contact maintenance.

    Evidence GFP-PANX1 domain deletion and Y308F mutagenesis in polarized MDCK cells with imaging

    PMID:31102595

    Open questions at the time
    • Whether polarity phenotype requires channel activity unknown
    • Single lab
  12. 2021 High

    Established PANX1-P2RY12 coupling in microglia controlling capillary interactions and cerebral blood flow, defining a discrete neurovascular signaling axis.

    Evidence PANX1-/- and P2RY12-/- mice, microglial depletion, and blood flow measurements

    PMID:34489419

    Open questions at the time
    • Specific purine released and its receptor binding kinetics not defined
  13. 2021 Medium

    Identified recessive PANX1 variants (S238P, R300Q) that alter glycosylation and cause aberrant activation leading to oocyte death and female infertility, establishing PANX1 in reproduction.

    Evidence Whole exome sequencing, glycosylation Western blot, electrophysiology, and IVF oocyte assays

    PMID:33495594

    Open questions at the time
    • Mechanistic link between altered glycosylation and oocyte death not resolved
  14. 2022 Medium

    Revealed species-specific PANX1 activation—human PANX1 responds to P2X7 but not high K+—and human polymorphisms (Q5H gain-, E390D loss-of-function), clarifying translational caveats and natural functional variation.

    Evidence Dye uptake and electrophysiology comparing mouse and human PANX1 and polymorphic variants in Panx1-null cells

    PMID:38100403

    Open questions at the time
    • Structural basis of species difference in K+ sensitivity not defined
  15. 2022 Medium

    Linked plasma membrane cholesterol to PANX1 lateral mobility and activity, showing cholesterol depletion enhances channel function while reducing diffusion.

    Evidence FRAP, electrophysiology, dye uptake, and ATP release with cholesterol manipulation in astrocytes

    PMID:36291086

    Open questions at the time
    • Whether cholesterol binds PANX1 directly unknown
  16. 2022 Medium

    Showed PANX1 orthologs exert dual pro- and anti-seizure roles via ATP/P2rx7 signaling in zebrafish, broadening understanding of PANX1 in excitability.

    Evidence panx1a-/- and pharmacological blockade in zebrafish larvae with electrophysiology, behavior, and RNA-seq

    PMID:35585187

    Open questions at the time
    • Mechanism reconciling opposing pro/anti-seizure effects not resolved
  17. 2022 Medium

    Defined a TLR2/caspase-5/PANX1 axis in macrophages connecting necrotic cell danger signals to ATP secretion and NLRP3 inflammasome activation in kidney injury.

    Evidence Conditioned medium from necrotic tubular cells with siRNA knockdown of Panx1, TLR2, caspase-5

    PMID:35473933

    Open questions at the time
    • Direct caspase-5 cleavage site on PANX1 not mapped
  18. 2023 High

    Demonstrated both neuronal and astrocytic PANX1 are required for hippocampal LTP/LTD and long-term spatial memory, establishing a cognitive role for the channel.

    Evidence Global and cell-type specific Panx1 KO mice with radial maze and field potential recordings

    PMID:37365910

    Open questions at the time
    • Molecular link between PANX1 ATP release and plasticity machinery not fully resolved
  19. 2024 Medium

    Resolved a niNMDAR→Src→PANX1→ATP→P2X4 pathway producing hippocampal LTD, defining a precise signaling chain for PANX1 in synaptic depression.

    Evidence Patch-clamp in hippocampal slices with NMDAR, Src, PANX1, and P2X4 pharmacology plus ATP rescue

    PMID:39709529

    Open questions at the time
    • How Src activation gates PANX1 structurally not shown
  20. 2024 High

    Showed neuronal PANX1 drives inflammatory pain cell-autonomously by enhancing DRG excitability and supporting Wnt/β-catenin neurogenesis, placing PANX1 in peripheral sensitization.

    Evidence Global and neuron-specific Panx1 KO mice with von Frey, electrophysiology, Ca2+ imaging, and neurogenesis markers

    PMID:38685116

    Open questions at the time
    • Relative contributions of channel ATP release vs neurogenesis to pain not separated
  21. 2024 High

    Defined a cardiomyocyte metabolic and immune role for PANX1, with deletion shifting metabolism toward glycolysis and protecting against isoproterenol-induced hypertrophy and neutrophil recruitment.

    Evidence Cardiomyocyte-specific Panx1 KO mice with metabolic flux, Yo-Pro-1 uptake, and flow cytometry

    PMID:38957990

    Open questions at the time
    • Mechanism linking PANX1 ATP release to metabolic substrate switching not resolved
  22. 2024 Medium

    Identified a TNFα→caspase-8/3→PANX1 cleavage pathway enhancing ATP release that activates P2RX7-mediated antitumor immunity during immunogenic cell death.

    Evidence PANX1 cleavage and ATP release assays with caspase inhibitors and immune activation readouts in colorectal cancer models

    PMID:38195677

    Open questions at the time
    • In vivo contribution to clinical immunotherapy response not established
  23. 2024 Medium

    Placed PANX1 ATP release downstream of FAM3A to suppress hepatic gluconeogenesis (P2Y/Akt-FOXO1) and lipogenesis (CaM/JNK/AP1), defining a hepatic metabolic signaling node.

    Evidence Co-IP/MS, global Panx1 KO and rescue, and in vivo metabolic testing

    PMID:38937853

    Open questions at the time
    • Direct vs autocrine purinergic step in hepatocytes not isolated
  24. 2024 Medium

    Demonstrated a narrow expression window for PANX1 in endometrial decidualization, with both overexpression and knockdown impairing decidualization markers, linking PANX1 to implantation failure.

    Evidence Bidirectional PANX1 manipulation in human endometrial stromal cells with decidualization markers and ATP measurement

    PMID:41775813

    Open questions at the time
    • Downstream purinergic receptor in endometrium not identified
  25. 2024 Medium

    Identified raptinal as an inhibitor of caspase-activated PANX1 acting by a distinct mechanism, suppressing apoptotic 'find-me' ATP signals, extracellular vesicle formation, and NLRP3 activation.

    Evidence Electrophysiology, biochemistry, ATP release, EV quantification, and NLRP3 assays versus known inhibitors

    PMID:38336804

    Open questions at the time
    • Binding site of raptinal on PANX1 not mapped
  26. 2024 Medium

    Identified dominant PANX1 variants (S137L, N326del) altering glycosylation and channel activation that cause oocyte death and infertility, expanding the inheritance modes of PANX1 reproductive disease.

    Evidence Whole exome sequencing with glycosylation, electrophysiology, ATP release, and human/mouse oocyte IVF assays

    PMID:39232764

    Open questions at the time
    • Dominant mechanism (gain-of-function vs dominant-negative) not formally resolved
  27. 2024 Low

    Proposed PANX1 acts downstream of TGM2 to promote lipid deposition in nephropathy, placing PANX1 in a renal lipid metabolism pathway.

    Evidence Co-immunoprecipitation, siRNA knockdown, and PPARα/PANK1 Western blot in adriamycin nephropathy models

    PMID:38734063

    Open questions at the time
    • Single Co-IP without reciprocal validation
    • Pathway placement from one cell model only
  28. 2025 High

    Defined the structural basis of PANX1 permeation selectivity at near-atomic resolution, showing W74 conformational plasticity and W74-R75 cation-π interactions gate the channel between chloride-only and ATP-permeant states, with mefloquine as a positive modulator.

    Evidence Cryo-EM structure determination with conformational analysis, W74/R75 mutagenesis, and mefloquine electrophysiology

    PMID:41381453

    Open questions at the time
    • How upstream activators (P2X7, Src, caspase) drive W74 conformational change not shown
  29. 2025 Medium

    Showed an N-terminal truncation mutant Panx1(1-89) forms a constitutively active, K+-enhanced ATP-releasing channel that retains inhibitor sensitivity, linking PANX1 fragments to metastasis.

    Evidence Electrophysiology, ATP release, inhibitor profiling, and high-K+ stimulation of Panx1(1-89)-expressing cells

    PMID:40087867

    Open questions at the time
    • In vivo generation and metastatic mechanism of the truncation not established
  30. 2025 Medium

    Demonstrated ATP-driven macropinocytosis internalizes PANX1 via a W74-, ARF6-, PI3K-, and actin-dependent route, revealing feedback regulation of channel surface levels.

    Evidence Cell area measurement, W74 mutagenesis, ARF6(Q67L) expression, and PI3K/actin/GTPase inhibitors with macropinosome co-localization in Neuro2a cells

    PMID:41250870

    Open questions at the time
    • Physiological trigger and consequence of PANX1 internalization in vivo unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the distinct upstream activators (P2X7 complex formation, Src phosphorylation, caspase cleavage, mechanical and lipid-environment cues) converge to drive the W74/R75 conformational transition that opens the ATP-permeant pore remains unresolved.
  • No structure of an activated, P2X7-bound or Src-phosphorylated PANX1
  • Coupling between cleavage events and the W74 gate not mapped
  • How glycosylation status biochemically controls gating unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 6 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005886 plasma membrane 4 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-168256 Immune System 4 R-HSA-112316 Neuronal System 3 R-HSA-162582 Signal Transduction 3 R-HSA-1430728 Metabolism 2 R-HSA-5357801 Programmed Cell Death 2
Partners
ACTBACTR3FAM3AP2RX7TGM2
Complex memberships
P2X7R-PANX1 pore complex

Evidence

Reading pass · 30 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 Cortical spreading depression (CSD) causes neuronal PANX1 megachannel opening and subsequent caspase-1 activation, followed by HMGB1 release from neurons and NF-κB activation in astrocytes; pharmacological suppression of this cascade abolished CSD-induced trigeminovascular activation, dural mast cell degranulation, and headache. In vivo pharmacological blockade and genetic suppression in mouse model of cortical spreading depression; measurement of trigeminovascular activation, HMGB1 release, caspase-1 activity Science High 23449592
2017 PANX1 forms a pore complex with P2X7 receptor; genetic loss of P2X7 or pharmacological inhibition of the P2X7-PANX1 pore complex suppresses spreading depolarization, reduces frequency and amplitude of depolarization events, and suppresses downstream neuroinflammatory gene expression (IL-1β, iNOS, COX-2) and trigeminovascular activation markers. Genetic knockout of P2x7, pharmacological pore complex inhibitors in wild-type mice and familial hemiplegic migraine mutant mice; electrophysiological thresholds, immunohistochemistry for inflammatory markers, CGRP/c-Fos expression Brain High 28430869
2010 Intracellular cysteine 346 of PANX1 is a critical regulatory residue; C346S mutation causes constitutively active (leaky) hemichannel activity and subsequent cell death, as demonstrated by increased dye uptake and electrophysiological profiling; mutations at other intracellular cysteines did not substantially alter channel properties. Site-directed mutagenesis of PANX1 cysteine residues; dye uptake assays and electrophysiology in Xenopus oocytes and N2A cells Journal of Biological Chemistry High 20829356
2013 The food dye FD&C Blue No. 1 (BB FCF) is a selective inhibitor of PANX1 channels with an IC50 of 0.27 µM, with no significant effect on P2X7R at concentrations up to 100 µM; the related dye FD&C Green No. 3 similarly selectively inhibited PANX1; oxidized ATP (a P2X7R antagonist) did not significantly inhibit PANX1 channels. Electrophysiological recordings and dye uptake assays in cells expressing PANX1 or P2X7R; dose-response pharmacology Journal of General Physiology High 23589583
2016 A homozygous PANX1 missense variant p.Arg217His results in loss-of-function of the channel (assessed by dye uptake, ATP release, and electrophysiology) without affecting glycosylation or cell surface trafficking; the variant is not dominant-negative when co-expressed with wild-type PANX1; homozygosity causes multisystem dysfunction including intellectual disability, sensorineural hearing loss, skeletal defects, and primary ovarian failure. Whole exome sequencing; expression in HeLa, N2A, HEK293T, Ad293 cells; dye uptake, ATP release assays, electrophysiology; co-expression with wild-type PANX1 Journal of Biological Chemistry High 27129271
2008 PANX1 channels make no detectable contribution to the P2X2 receptor I2 (dilated permeability) state; the I2 state is an intrinsic P2X2 property correlated with conformational changes in the cytosolic domain rather than Panx1 opening. Patch-clamp coordinated spectroscopy; tetracysteine tag/biarsenical fluorophore conformational assay; dye permeability measurements; Panx1 knockdown/inhibition Proceedings of the National Academy of Sciences High 18689682
2013 Endogenous PANX1 interacts with actin in neural stem/progenitor cells (NSC/NPCs) and also with actin-related protein 3 (Arp3); PANX1 plays roles in NSC/NPC migration and neurite extension associated with cytoskeletal dynamics. Co-immunoprecipitation of endogenous proteins; scratch wound and neurite extension assays; Panx1 knockdown in VZ NSC/NPCs Cell Communication and Signaling Medium 23964896
2014 PANX1 controls cellular properties of keratinocytes and dermal fibroblasts; Panx1 KO fibroblasts show increased proliferation, reduced collagen gel contraction comparable to probenecid-treated WT fibroblasts, and fail to upregulate α-smooth muscle actin in response to TGF-β (a marker of myofibroblast differentiation); Panx1 KO keratinocytes are more migratory; Panx1 KO mice show delayed wound healing and altered skin thickness. Panx1 KO mouse model; histology; scratch wound assays; proliferation assays; collagen gel contraction; TGF-β stimulation; pharmacological blockade with probenecid Journal of Investigative Dermatology High 24522432
2016 P2X7R and PANX1 are co-expressed in osteocytes and together form a major pathway for flow-induced ATP release in bone mechanosignaling; high glucose conditions (simulating type 1 diabetes) blunt P2X7R- and flow-induced Ca2+ signaling and ATP release from osteocytes, associated with altered P2X7R and PANX1 expression. Western blot for co-expression; oscillatory fluid shear stress assays; Ca2+ response measurements; ATP release measurements; diabetic mouse model (Akita); high glucose cell culture PLoS One Medium 27159053
2021 PANX1 channels in microglia release purines that activate microglial P2RY12 receptors; P2RY12 signaling regulates capillary-associated microglia (CAM) interactions with brain capillaries; PANX1-/- and P2RY12-/- mice show capillary dilation, increased blood flow, and impaired vasodilation, phenocopying microglial depletion. PANX1-/- and P2RY12-/- mouse models; microglial depletion; morphological/ultrastructural analysis; blood flow measurements; pharmacological assays Nature Communications High 34489419
2022 TLR2 activation in macrophages by danger signals from necrotic tubular epithelial cells activates PANX1 channels via caspase-5, leading to ATP secretion through PANX1 and subsequent NLRP3 inflammasome activation; this TLR2/caspase-5/Panx1 axis drives necroinflammation in acute kidney injury. Conditioned medium from necrotic TECs applied to macrophages; siRNA knockdown of Panx1, TLR2, caspase-5; NLRP3 inflammasome activation assays; ATP measurement Cell Death Discovery Medium 35473933
2024 TNFα promotes PANX1 cleavage via a caspase 8/3-dependent pathway in colorectal cancer cells, enhancing ATP release; this ATP release through PANX1 activates P2RX7 receptor-mediated antitumor immunity, including dendritic cell maturation and T-cell activation during chemotherapy-induced immunogenic cell death. PANX1 cleavage assay; caspase inhibitor experiments; ATP release measurements; immune cell activation assays in vitro and in vivo; P2RX7 blockade Cell Death & Disease Medium 38195677
2019 PANX1 in polarized MDCK cells is preferentially delivered to the apical membrane domain; the cell-surface targeting domain maps to residues 307–379; a Y308F mutation (disrupting a putative YxxΦ basolateral sorting motif) or a Δ379 truncation causes MDCK cells to lose cell-cell contacts and polarization capacity, switching to a fibroblast-like phenotype. GFP-tagged Panx1 in polarized MDCK cells and BICR-M1Rk cells; domain deletion and point mutagenesis; live-cell imaging; immunofluorescence; spheroid culture Experimental Cell Research Medium 31102595
2024 PANX1-mediated ATP release is required for FAM3A's suppression of hepatic gluconeogenesis and lipogenesis; mechanistically, PANX1-released ATP activates P2Y receptors to inhibit gluconeogenesis via the Akt-FOXO1 pathway; PANX1-released ATP also activates calmodulin (CaM), which interacts with JNK to inhibit AP1 transcription factor and repress FAS expression and lipogenesis; FAM3A stimulates PANX1 expression via HSF1; FAM3A overexpression fails to suppress gluconeogenesis/lipogenesis in PANX1-deficient hepatocytes. Co-immunoprecipitation with MS; PANX1 global KO mice; adenovirus/AAV gene overexpression/knockdown in vivo; OGTT, PTT, ITT metabolic tests; ATP release measurements; Western blot Military Medical Research Medium 38937853
2024 Non-ionotropic NMDA receptor (niNMDAR) signaling activates PANX1 via Src kinase; PANX1 releases ATP (but is not permeable to Ca2+) to activate P2X4 purinergic receptors, producing long-term depression (LTD) at CA3-CA1 hippocampal synapses following low-frequency stimulation. Whole-cell patch-clamp electrophysiology in rat hippocampal slices; competitive NMDAR antagonist (MK-801) applied transiently vs continuously; pharmacological blockade of Panx1 (with rescue by exogenous ATP); P2X4 antagonist (5-BDBD); Src kinase inhibitors Journal of Physiology Medium 39709529
2023 Both astrocyte and neuronal PANX1 are required for long-term spatial reference memory but not spatial working memory in mice; global Panx1 deletion attenuates LTP and LTD at Schaffer collateral-CA1 synapses without altering basal synaptic transmission or paired-pulse facilitation. Global and cell-type specific Panx1 transgenic KO mice; 8-arm radial maze; hippocampal slice field potential recordings; LTP and LTD induction protocols ASN Neuro High 37365910
2021 Homozygous PANX1 missense variants (p.Ser238Pro and p.Arg300Gln) alter PANX1 glycosylation pattern in cultured cells, cause aberrant PANX1 channel activation, and result in mouse oocyte death after in vitro fertilization; these variants follow autosomal recessive inheritance and cause female infertility. Whole exome sequencing; Western blot for glycosylation; electrophysiology and dye uptake for channel function; in vitro fertilization mouse oocyte assay European Journal of Human Genetics Medium 33495594
2025 Cryo-EM structural analysis reveals that PANX1 channel permeation selectivity is controlled by structural plasticity at the extracellular entrance formed by seven W74 residues; W74 side chains sample conformations from a constricted state permissive to chloride only, to a dilated state compatible with ATP; these states are coupled to variable cation-π interactions between W74 and R75; mefloquine acts as a positive modulator binding near the side tunnel to enhance ion flow. Cryo-EM structure determination; molecular dynamics/conformational analysis; mutagenesis (W74, R75); electrophysiology with mefloquine Nature Communications High 41381453
2025 A metastasis-associated N-terminal truncation mutant Panx1(1-89) forms a constitutively active membrane channel capable of releasing ATP independently of full-length PANX1; basic structure-function features of the channel pore are conserved; elevated extracellular K+ enhances Panx1(1-89)-mediated conductance; the truncated channel retains sensitivity to most full-length PANX1 inhibitors. Electrophysiology; ATP release assays; pharmacological inhibitor profiling; extracellular K+ stimulation experiments in cells expressing Panx1(1-89) FEBS Journal Medium 40087867
2025 ATP stimulates macropinocytosis in Neuro2a neuroblastoma cells, driving cell size increase and PANX1 internalization to macropinosomes; mutation of extracellular tryptophan W74 in PANX1 abolishes ATP-evoked cell area enlargement; ARF6(Q67L) expression phenocopies ATP-induced PANX1 internalization; PI3K inhibition, actin disruption, and GTPase inhibition abolish ATP-induced PANX1 internalization. Cell area measurement; fluorescent PANX1 constructs; W74 mutagenesis; ARF6 Q67L expression; pharmacological inhibitors of PI3K, actin polymerization; co-localization with macropinosomal cargo Biology Open Medium 41250870
2024 Raptinal simultaneously induces apoptosis and inhibits caspase-activated PANX1 via a mechanism distinct from carbenoxolone and trovafloxacin; PANX1 inhibition by raptinal suppresses ATP 'find-me' signal release, formation of apoptotic cell-derived extracellular vesicles, and NLRP3 inflammasome activation. Biochemical, cell biological, and electrophysiological approaches; caspase activation assays; PANX1 cleavage assays; ATP release; extracellular vesicle quantification; NLRP3 inflammasome assay; comparison with known inhibitors Cell Death & Disease Medium 38336804
2024 PANX1 deletion in cardiomyocytes increases glycolytic metabolism and glycolytic ATP production with concurrent decrease in oxidative phosphorylation; isoproterenol treatment of cardiomyocytes induces PANX1-dependent ATP release and Yo-Pro-1 uptake; cardiomyocyte-specific Panx1 KO mice are protected from isoproterenol-induced cardiac hypertrophy and show decreased immune cell (particularly neutrophil) recruitment to myocardium. Cardiomyocyte-specific Panx1 KO mouse (Panx1MyHC6); metabolic flux analysis in vivo and in vitro; isoproterenol treatment; spironolactone and siRNA-mediated PANX1 blockade; Yo-Pro-1 uptake; flow cytometry for immune cells Circulation Research High 38957990
2022 Human and mouse PANX1 orthologs differ in activation mechanisms: human PANX1 is insensitive to stimulation with high extracellular [K+] but responds to P2X7 receptor activation, while mouse PANX1 responds to both stimuli; human PANX1 polymorphism Q5H (rs1138800) is a gain-of-function and E390D (rs74549886) is a loss-of-function variant for P2X7-mediated channel activation. Dye uptake and electrophysiology in N2a neuroblastoma cells expressing endogenous mPanx1 or exogenous hPanx1; human PANX1 polymorphic variants expressed in Panx1-null cells; high K+ stimulation; P2X7 receptor activation PLoS One Medium 38100403
2022 Cholesterol depletion (by methyl-β-cyclodextrin) and inhibition of cholesterol synthesis (lovastatin) decrease lateral diffusion of PANX1 in the plasma membrane (assessed by FRAP) while enhancing PANX1 channel activity (dye uptake, ATP release, ionic current) in cholesterol-depleted astrocytes and PANX1-transfected cells. FRAP for membrane mobility; electrophysiology; dye uptake; ATP release assays; pharmacological cholesterol manipulation in astrocytes and transfected cells Cells Medium 36291086
2023 In zebrafish, Panx1a and Panx1b (both homologous to human PANX1) exert dual pro- and anti-seizure activities via ATP release and P2rx7 receptor signaling; loss of Panx1a function reduces ictal-like events and seizure-like locomotion induced by pentylenetetrazol; transcriptome profiling reveals distinct metabolic and cell-signaling states associated with loss of Panx1a. Genetic KO (panx1a-/-) and pharmacological blockade of Panx1a/Panx1b in zebrafish larvae; electrophysiology; behavioral analysis; RNA-seq; ATP release measurements Communications Biology Medium 35585187
2017 cAMP-mediated pathway does NOT drive ATP release from red blood cells (RBCs) through PANX1; Panx1-/- mice show no decrease in exercise performance; treatment with stable cAMP analog does not induce ATP release from WT or Panx1-/- RBCs; multiple pharmacological AC activators increase intracellular cAMP but do not induce ATP release. Panx1-/- mouse model; exercise performance testing; RBC ex vivo ATP release assays; cAMP measurement by mass spectrometry; pharmacological adenylate cyclase activation American Journal of Physiology - Cell Physiology Medium 28855161
2024 Neuronal PANX1 drives peripheral sensitization in inflammatory pain through cell-autonomous effects on neuronal excitability; neuron-specific Panx1 KO reduces pain sensitivity after CFA-induced inflammation; neuronal Panx1 enhances DRG neuron response to ATP; Panx1 supports Wnt/β-catenin-dependent DRG neurogenesis; ATP release from Panx1 channels increases Ca2+ responses in DRGNs and satellite glial cells. Global and neuron-specific Panx1 KO mice; von Frey test after CFA injection; confocal microscopy; Sholl analysis; electrophysiology in Neuro2a and DRG neurons; ethidium bromide dye uptake; calcium imaging; β-galactosidase staining in transgenic mice Military Medical Research High 38685116
2024 PANX1 variants (p.Ser137Leu and p.Asn326del) alter PANX1 glycosylation, cause aberrant channel activation, affect ATP release and membrane electrophysiological properties, and result in human and mouse oocyte death in vitro; both variants follow autosomal dominant inheritance. Whole exome sequencing; Western blot for glycosylation; ATP release measurement; electrophysiology; in vitro mouse and human oocyte fertilization assay Journal of Ovarian Research Medium 39232764
2025 TGM2 interacts with PANX1 (co-immunoprecipitation); TGM2-PANX1 interaction promotes lipid deposition; knockdown or pharmacological inhibition of PANX1 decreases levels of PPARα and PANK1 induced by adriamycin, suggesting PANX1 operates downstream of TGM2 in a pathway regulating lipid metabolism. Co-immunoprecipitation; siRNA knockdown of PANX1; Western blot for PPARα and PANK1; adriamycin nephropathy cell and mouse model; YR-7 peptide treatment Translational Research Low 38734063
2024 PANX1 channel activity is required for endometrial decidualization: PANX1 overexpression in human endometrial stromal cells (HESCs) increases extracellular ATP and impairs decidualization markers (PRL, IGFBP-1) and cytoskeletal morphology; PANX1 knockdown also impairs decidualization, indicating that normal PANX1 expression level is required; this mechanism is associated with recurrent implantation failure. PANX1 plasmid overexpression and siRNA knockdown in HESCs; extracellular ATP detection; Western blot for PRL and IGFBP-1; immunofluorescence for cytoskeleton; animal model validation Scientific Reports Medium 41775813

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Spreading depression triggers headache by activating neuronal Panx1 channels. Science (New York, N.Y.) 402 23449592
2021 Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. Nature communications 240 34489419
2001 RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science (New York, N.Y.) 185 11729322
2017 Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation. Brain : a journal of neurology 101 28430869
2013 The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. The Journal of general physiology 79 23589583
2008 Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels. Proceedings of the National Academy of Sciences of the United States of America 72 18689682
2016 A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction. The Journal of biological chemistry 64 27129271
2013 Panx1 regulates neural stem and progenitor cell behaviours associated with cytoskeletal dynamics and interacts with multiple cytoskeletal elements. Cell communication and signaling : CCS 61 23964896
2014 Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing. The Journal of investigative dermatology 59 24522432
2006 Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proceedings of the National Academy of Sciences of the United States of America 51 17077144
2015 Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival. Glia 50 26096155
2016 P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PloS one 49 27159053
1990 Two group I mitochondrial introns in the cob-box and coxI genes require the same MRS1/PET157 nuclear gene product for splicing. Current genetics 47 1699677
2003 2-Cys peroxiredoxin PfTrx-Px1 is involved in the antioxidant defence of Plasmodium falciparum. Molecular and biochemical parasitology 45 12946843
1986 Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Current genetics 42 2834089
2024 TNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer. Cell death & disease 41 38195677
1996 Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Free radical biology & medicine 39 8886791
2022 TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury. Cell death discovery 37 35473933
2016 Parental vitamin D deficiency during pregnancy is associated with increased blood pressure in offspring via Panx1 hypermethylation. American journal of physiology. Heart and circulatory physiology 36 27769995
2014 Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet. Frontiers in cellular neuroscience 36 25520621
1987 A yeast nuclear gene, MRS1, involved in mitochondrial RNA splicing: nucleotide sequence and mutational analysis of two overlapping open reading frames on opposite strands. The EMBO journal 36 2443348
2010 Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity. The Journal of biological chemistry 35 20829356
2017 Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. American journal of physiology. Cell physiology 32 28855161
2022 Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles. International journal of molecular sciences 29 35163442
2015 Normal Taste Acceptance and Preference of PANX1 Knockout Mice. Chemical senses 27 25987548
2010 Cloning and characterization of a xylanase, KRICT PX1 from the strain Paenibacillus sp. HPL-001. Biotechnology advances 22 20493247
2019 Panx1 promotes invasion-metastasis cascade in hepatocellular carcinoma. Journal of Cancer 21 31737105
2021 Homozygous variants in PANX1 cause human oocyte death and female infertility. European journal of human genetics : EJHG 20 33495594
2010 Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP). The Journal of biological chemistry 20 20064926
1992 The MRS1 gene of S. douglasii: co-evolution of mitochondrial introns and specific splicing proteins encoded by nuclear genes. Gene expression 20 1333316
2018 A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model. Frontiers in molecular neuroscience 19 29780304
2024 Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy. Circulation research 18 38957990
2022 High PANX1 Expression Leads to Neutrophil Recruitment and the Formation of a High Adenosine Immunosuppressive Tumor Microenvironment in Basal-like Breast Cancer. Cancers 18 35884429
2017 Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice. Channels (Austin, Tex.) 18 28745932
2016 Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. PloS one 18 27099931
2017 Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells. Investigative ophthalmology & visual science 17 29098296
2017 Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function. Frontiers in molecular neuroscience 16 29234270
2010 The Mrs1 splicing factor binds the bI3 group I intron at each of two tetraloop-receptor motifs. PloS one 16 20126554
2000 Site-directed mutagenesis of the yeast resolving enzyme Cce1 reveals catalytic residues and relationship with the intron-splicing factor Mrs1. The Journal of biological chemistry 16 10825168
2021 Design and synthesis of the first indole-based blockers of Panx-1 channel. European journal of medicinal chemistry 15 34174741
2014 Investigation of olfactory function in a Panx1 knock out mouse model. Frontiers in cellular neuroscience 15 25309319
2022 Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology 14 35585187
2021 Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice. International journal of molecular sciences 14 33525532
2024 Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage. Biological research 13 38576018
2024 PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. Military Medical Research 13 38937853
2022 New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies. International journal of molecular sciences 13 35563213
2023 Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice. ASN neuro 12 37365910
2022 Defining Steric Requirements at CB1 and CB2 Cannabinoid Receptors Using Synthetic Cannabinoid Receptor Agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX-2, NNL-1, and Their Analogues. ACS chemical neuroscience 12 35404067
2024 The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell death & disease 10 38336804
2021 Inhibiting of circ-TLK1 inhibits the progression of glioma through down-regulating PANX1 via targeting miR-17-5p. Journal of molecular histology 10 34181173
2011 Design and synthesis of a quintessential self-transmissible IncX1 plasmid, pX1.0. PloS one 10 21625636
2019 Destination and consequences of Panx1 and mutant expression in polarized MDCK cells. Experimental cell research 9 31102595
2019 P2X7R and PANX-1 channel relevance in a zebrafish larvae copper-induced inflammation model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 9 31136852
2024 Non-ionotropic NMDAR signalling activates Panx1 to induce P2X4R-dependent long-term depression in the hippocampus. The Journal of physiology 8 39709529
2023 Structure-Based Design and Synthesis of Stapled 10Panx1 Analogues for Use in Cardiovascular Inflammatory Diseases. Journal of medicinal chemistry 8 37703077
2022 Activity and Stability of Panx1 Channels in Astrocytes and Neuroblastoma Cells Are Enhanced by Cholesterol Depletion. Cells 8 36291086
2020 Phase I metabolism of synthetic cannabinoid receptor agonist PX-1 (5F-APP-PICA) via incubation with human liver microsomes and UHPLC-HRMS. Biomedical chromatography : BMC 8 31863591
2024 miR-224-5p alleviates preeclampsia-like mouse symptoms by targeting PANX1 to inhibit ferroptosis in trophoblast cells. Placenta 7 39426351
2023 Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma. Journal of Cancer 7 37056395
2019 Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice. Bioscience reports 7 30745457
2024 Glial Cx43 hemichannels and neuronal Panx1 hemichannels and P2X7 receptors orchestrate presynaptic homeostatic plasticity. Cellular signalling 6 38395185
2023 Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity. International journal of molecular sciences 6 37958624
2022 A novel heterozygous variant in PANX1 is associated with oocyte death and female infertility. Journal of assisted reproduction and genetics 6 35834089
2021 The Contribution of Astrocyte and Neuronal Panx1 to Seizures Is Model and Brain Region Dependent. ASN neuro 6 33910381
2024 Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway. Translational research : the journal of laboratory and clinical medicine 5 38734063
2024 A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility. Journal of ovarian research 5 39232764
2024 Propofol Triggers Cell Death in Lung Cancer Cells by Increasing PANX1 Expression, Activating the Mitochondrial Cell Death Pathway, and Enhancing ROS Levels. Discovery medicine 5 39600278
2023 Elabela-apelin-12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1-P2X7 signaling pathway. Journal of cellular biochemistry 5 36855998
2023 Cx43 Hemichannel and Panx1 Channel Modulation by Gap19 and 10Panx1 Peptides. International journal of molecular sciences 5 37511370
2022 A novel heterozygous variant in PANX1 causes primary infertility due to oocyte death. Journal of assisted reproduction and genetics 5 36469255
2024 Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain. Military Medical Research 4 38685116
2023 Loss of Panx1 function in zebrafish alters motor behavior in a lab-on-chip model of Parkinson's disease. Journal of neuroscience research 4 37688406
2022 The Interplay of Cx26, Cx32, Cx37, Cx40, Cx43, Cx45, and Panx1 in Inner-Ear Development of Yotari (dab1-/-) Mice and Humans. Biomedicines 4 35327391
2021 [Mechanism of Chuanxiong Rhizoma intervention on central sensitization of Panx1-Src-NMDAR-2B signaling pathway in neuropathic pain model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 4 34467730
2025 Synthesis of 3-Carboxy-6-sulfamoylquinolones and Mefloquine-Based Compounds as Panx1 Blockers: Molecular Docking, Electrophysiological and Cell Culture Studies. Molecules (Basel, Switzerland) 3 40430343
2024 Apically localized PANX1 impacts neuroepithelial expansion in human cerebral organoids. Cell death discovery 3 38212304
2024 The Ethanolic Extract of Polygala paniculata L. Blocks Panx1 Channels and Reduces Ischemic Brain Infarct in a Dose- and Sex-Dependent Way. Molecular neurobiology 3 39271622
1979 Cis- and trans-activity of P22 antirepressor protein against c-repression specified by the closely related Salmonella phages L and Px1. Molecular & general genetics : MGG 3 374992
2025 A metastasis-associated pannexin-1 mutant (Panx11-89) forms a minimalist ATP release channel. The FEBS journal 2 40087867
2025 Metabolomics and mass spectrometry imaging reveal the effect of Prunella vulgaris oil on chronic pelvic inflammatory disease: Exploring the mechanism from inhibition of PANX1. Journal of ethnopharmacology 2 40783103
2025 The impact of Panx1 on inflammation, immunity, and cancer: a comprehensive review. Frontiers in medicine 2 40978734
2024 Novel genetic variants in the NLRP3 inflammasome-related PANX1 and APP genes predict survival of patients with hepatitis B virus-related hepatocellular carcinoma. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2 39090420
2023 Astrocyte and neuronal Panx1 support long-term reference memory in mice. bioRxiv : the preprint server for biology 2 36711845
2023 Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis. International journal of experimental pathology 2 37594023
2025 Tanshinone IIA Inhibits Microglial Activation and Inflammation and Relieves Cerebral Ischemia‒Reperfusion Injury Through TGM2/PANX1. Biochemical genetics 1 41351813
2025 Structural basis of PANX1 permeation and positive modulation by mefloquine. Nature communications 1 41381453
2024 Potentially functional variants of CHMP4A and PANX1 in the pyroptosis-related pathway predict survival of patients with non-oropharyngeal head and neck squamous cell carcinoma. Molecular carcinogenesis 1 38860607
2024 Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1 Mice. Biomolecules 1 39334824
2023 Differential activation of mouse and human Panx1 channel variants. PloS one 1 38100403
2022 [Colonization performance and pyrene degradation characteristics of Stenotrophomonas maltophilia PX1]. Ying yong sheng tai xue bao = The journal of applied ecology 1 36131672
2018 [Sleep-wake cycle and experimental models of Panx1 mutations]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 1 30698564
2026 PANX1-mediated NLRP3 inflammasome activation promotes an adaptive doxorubicin resistance through IL-1β signaling in breast cancer. Cancer letters 0 41765358
2026 Abnormal elevated PANX1 expression hampers endometrial decidualization by upregulating extracellular ATP concentration in patients with recurrent implantation failure. Scientific reports 0 41775813
2026 Panx1 and P2X7R are associated with impaired skeletal health and delayed bone development in early onset of type 1 diabetes. Frontiers in endocrinology 0 42181174
2025 The Synergistic Role of P2rx7 and Panx1 in Regulating Alveolar Macrophage Pyroptosis and Exosome-Mediated Ferroptosis of Alveolar Epithelial Cells in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 40827894
2025 Electroacupuncture ameliorates mitochondrial dysfunction and alleviates traumatic brain injury via the PANX1/ATP/Ca2+ pathway. Behavioural brain research 0 41197910
2025 ATP increases murine neuroblastoma cell size through a PANX1- and macropinocytosis-dependent mechanism. Biology open 0 41250870
2025 Downregulation of intracellular ATP levels by PANX1 inhibits ovarian granulosa cell proliferation and mediates follicular dysplasia in elderly women. Reproductive biology 0 41319607
2024 A metastasis-associated Pannexin1 mutant (Panx1 1-89 ) forms a minimalist ATP release channel. bioRxiv : the preprint server for biology 0 38559162
2013 [Distribution and regulation of Panx1 protein]. Sheng li ke xue jin zhan [Progress in physiology] 0 24027825

Missed literature

Know a paper Affinage missed for PANX1? Flag it for the maintainers and the community.

No submissions yet.