Affinage

SNX17

Sorting nexin-17 · UniProt Q15036

Audit flag: ungrounded claim
Length
470 aa
Mass
52.9 kDa
Annotated
2026-06-10
25 papers in source corpus 24 papers cited in narrative 27 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SNX17 is an endosomal sorting adaptor that recognizes NPX(Y/F) motifs in the cytoplasmic tails of transmembrane cargo and retrieves them from the degradative pathway for recycling back to the plasma membrane (PMID:22492727, PMID:25059659). It engages a broad cargo set through distinct domains: its FERM-like domain binds the membrane-distal NPXY/NPXF motifs of β1/β5 integrins, KRIT1, and NHE3 (PMID:22492727, PMID:25059659), while its PX domain mediates association with LDL receptor family members and anchors SNX17 to PI(3)P-positive early/sorting endosomes (PMID:12169628, PMID:40349777). Cargo capture protects substrates from lysosomal degradation, as shown for integrins (PMID:22492727), SERCA2a (PMID:30025651), and LDLR (PMID:40071387), and is the basis for SNX17's role in integrin-dependent cell migration (PMID:22492727). SNX17 executes recycling by recruiting the Retriever complex through its C-terminal region binding the VPS35L/VPS26C interface, operating together with the Commander/CCC and WASH machinery, and by recruiting the EHD1 fission GTPase to bud SNX17-coated carriers (PMID:32041776, PMID:36302387, PMID:39653850). Its activity is autoinhibited by an intramolecular contact between the C-terminal region and the cargo-binding pocket that is relieved upon cargo and PI(3)P binding, and cargo recycling is further gated by Ser38 phosphorylation in the PX domain that abolishes PI(3)P binding (PMID:39653850, PMID:40349777). Through this sorting function SNX17 supports T cell receptor and LFA-1 surface delivery and immune synapse formation (PMID:25439), antigen processing and cross-presentation in dendritic cells (PMID:39559950), and synaptic structural plasticity during LTP via β1-integrin recycling (PMID:37141105, PMID:40920104). In lipoprotein metabolism, SNX17 binds an acidic-pH-induced conformation of the LDLR tail to recycle the receptor, a step that PCSK9 blocks to divert LDLR to lysosomal degradation (PMID:40071387).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2002 Medium

    Established SNX17 as a direct binder of LDL receptor family cytoplasmic domains and an endosomal protein influencing receptor endocytosis, opening the question of how it sorts membrane cargo.

    Evidence Co-IP, fractionation/colocalization with EEA1 and Rab4, and LDL endocytosis assays

    PMID:12169628

    Open questions at the time
    • Binding ascribed to PX domain rather than later-defined FERM cargo pocket
    • No recycling machinery identified
    • Single cargo family tested
  2. 2008 Medium

    Defined the NPXY motif as the cargo recognition signal and placed SNX17 in basolateral/somatodendritic recycling of LRP1.

    Evidence NPXY mutagenesis with trafficking readouts in polarized MDCK cells and neurons

    PMID:19005208

    Open questions at the time
    • Domain responsible for NPXY recognition not yet mapped
    • Downstream coat/fission machinery unknown
  3. 2012 High

    Showed SNX17 retrieves β integrins from lysosomal degradation via FERM-domain NPXY recognition independent of retromer, linking the adaptor to cell migration and broadening its cargo repertoire to integrins and viral entry.

    Evidence SILAC proteomics, NPXY mutagenesis, lysosomal inhibitor rescue, migration assays, and PV infection knockdown studies

    PMID:22492727 PMID:23115288 PMID:25408867

    Open questions at the time
    • Identity of the recycling effector complex not yet defined
    • Retromer-independence left open which machinery substitutes
  4. 2014 High

    Provided atomic-resolution definition of FERM-domain NPXF cargo recognition through the SNX17-KRIT1 co-crystal structure.

    Evidence 3.0 Å co-crystal structure, GST pulldown, site-directed mutagenesis, affinity measurements

    PMID:25059659

    Open questions at the time
    • Structure captures cargo binding but not autoinhibited or membrane-bound states
    • No coat complex in the structure
  5. 2015 Medium

    Extended SNX17 cargo handling to immune receptors, showing FERM-dependent surface delivery of TCR and LFA-1 underlies T cell activation.

    Evidence Domain truncation, siRNA knockdown, flow cytometry surface quantification, TCR recycling and conjugate assays

    PMID:25825439

    Open questions at the time
    • Recycling effector machinery not defined in T cells
    • Direct vs indirect TCR binding not fully resolved
  6. 2018 Medium

    Demonstrated that SNX17 loss drives lysosomal degradation of SERCA2a, with physiological consequences for cardiac Ca2+ handling and arrhythmia.

    Evidence Co-IP domain mapping, lysosomal inhibitor rescue, Ca2+ imaging, ECG in a rat MI model

    PMID:30025651

    Open questions at the time
    • PX-domain-mediated binding to an intracellular cargo differs from NPXY paradigm
    • Recycling versus stabilization mechanism unclear
  7. 2019 Medium

    Identified EHD1 as the fission GTPase that resolves SNX17 carriers and showed SNX17 sorts Kv1.5, connecting the adaptor to endosomal membrane budding and ion channel surface levels.

    Evidence In vitro EHD1 binding, colocalization quantification, EHD1 knockdown endosomal morphology, and a SNX17 KO rat with patch-clamp/optical mapping

    PMID:30939909 PMID:32041776

    Open questions at the time
    • How EHD1 recruitment is timed relative to cargo capture not resolved
    • Coat complex linking cargo to fission still undefined
  8. 2019 Medium

    Revealed a degradation-control role beyond recycling, in which SNX17 recruits USP9X to deubiquitinate and stabilize PCM1 during ciliogenesis.

    Evidence Co-IP, ubiquitination assays, ciliogenesis readouts under serum starvation

    PMID:31671755

    Open questions at the time
    • Whether this is an endosomal recycling function is unclear
    • Mechanism of USP9X recruitment not structurally defined
  9. 2022 High

    Mapped the SNX17 C-terminus as a multifunctional interaction module binding both PDLIM PDZ domains and the Commander complex, identifying the structural basis for effector recruitment.

    Evidence Proteomics, PDLIM7-SNX17 co-crystal structure, mutagenesis, biophysical binding assays

    PMID:36302387

    Open questions at the time
    • Functional consequence of PDLIM binding not established
    • Commander binding region structure with full complex not resolved
  10. 2023 Medium

    Placed SNX17 in a defined recycling pathway (SNX17-Retriever-CCC-WASH) required for synaptic plasticity, with PI(3)P- and activity-dependent recruitment driving β1-integrin surface delivery.

    Evidence Knockdown and pathway epistasis in hippocampal neurons, chemical LTP, spine morphology, p140Cap pulldown, and Snx17 haploinsufficient mice

    PMID:37141105 PMID:37704928

    Open questions at the time
    • Causal order of NMDAR/CaMKII signaling and SNX17 recruitment partly correlative
    • Full cargo set at synapses incompletely defined
  11. 2024 High

    Established the autoinhibition logic of the adaptor: cargo binding relieves an intramolecular C-terminal/cargo-pocket contact to expose the Retriever-binding interface, with PI(3)P providing a parallel recruitment input.

    Evidence Recombinant reconstitution with liposomes, structure-guided mutagenesis, biophysical binding quantification

    PMID:39653850

    Open questions at the time
    • In-cell dynamics of the autoinhibition switch not directly observed
    • How phosphorylation feeds into this switch not yet integrated
  12. 2025 Medium

    Defined Ser38 PX-domain phosphorylation as a regulatory switch that abolishes PI(3)P binding and inactivates SNX17 recycling.

    Evidence Phosphomimetic/phosphodead mutagenesis, PI(3)P binding, localization, and cargo recycling assays

    PMID:40349777

    Open questions at the time
    • Kinase responsible for Ser38 phosphorylation not identified
    • Physiological signal triggering this modification unknown
  13. 2025 High

    Resolved the PCSK9 mechanism on LDLR recycling, showing SNX17 binds an acidic-pH-induced LDLR tail conformation that PCSK9 prevents, diverting LDLR to lysosomes.

    Evidence SNX17 knockdown in cells and Ldlr KO mice, conformational analysis, Co-IP, LDLR recycling assays with mechanistic epistasis

    PMID:40071387

    Open questions at the time
    • Structural basis of pH-dependent tail conformational change not solved
    • How conformational change couples to FERM/PX engagement unclear
  14. 2025 Medium

    Expanded the cargo repertoire and physiological reach of SNX17 sorting to NHE3 stability, dendritic-cell antigen handling, VEGFR degradation, and STAT3-linked metabolism, while preprints define new coat assemblies (WIPI2/CROP2, mutually exclusive Commander assemblies).

    Evidence GST pulldown/mutagenesis (NHE3), DC knockdown functional assays, hindlimb ischemia mouse model (VEGFR), Co-IP (STAT3), and reconstitution/proteomics preprints

    PMID:39559950 PMID:40303303 PMID:40412610

    Open questions at the time
    • STAT3 direct-interaction claim rests on single Co-IP and is Low confidence
    • VEGFR degradation versus recycling outcome appears cargo-context specific
    • CROP2/Commander-assembly findings remain preprints awaiting peer review

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SNX17 integrates the phosphorylation switch, autoinhibition relief, PI(3)P sensing, and selection among distinct Commander/Retriever/WIPI2 coat assemblies to decide individual cargo fate remains unresolved.
  • No unified structural model of the cargo-loaded, membrane-bound, coat-engaged SNX17 complex
  • Determinants directing a cargo toward recycling versus degradation undefined
  • Upstream signaling controlling Ser38 phosphorylation unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 2
Localization
GO:0005768 endosome 4 GO:0005886 plasma membrane 3
Pathway
R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-168256 Immune System 2 R-HSA-9609507 Protein localization 2
Partners
EHD1ITGB1KRIT1LRP1OCIAD2USP9XVPS26CVPS35L
Complex memberships
Commander/CCC complexRetriever (VPS35L/VPS26C)

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 SNX17 binds to the intracellular domain of LDL receptor family members (LDLR, VLDLR, ApoER2, LRP) via its PX domain, localizes to vesicular structures partially overlapping with EEA1- and Rab4-positive endosomes, and enhances the endocytosis rate of LDLR. Co-immunoprecipitation, subcellular fractionation/immunofluorescence colocalization, functional endocytosis assay with rhodamine-labeled LDL The EMBO journal Medium 12169628
2008 SNX17 recognizes the NPXY motif (N26) in the cytoplasmic tail of LRP1 and mediates its recycling from basolateral sorting endosomes; mutation of this NPXY motif traps LRP1 in the basolateral sorting endosome, establishing SNX17's role in basolateral/somatodendritic recycling. NPXY motif mutagenesis, trafficking assays in polarized MDCK cells and hippocampal neurons, colocalization by immunofluorescence Molecular biology of the cell Medium 19005208
2012 SNX17 binds to the membrane-distal NPXY motif in β1 and β5 integrin cytoplasmic tails via its FERM-like domain, thereby preventing lysosomal degradation of β integrins and their associated α subunits; this retrieval does not depend on the retromer complex, and SNX17 depletion impairs cell migration. SILAC-based quantitative proteomics, siRNA knockdown, lysosomal inhibitor assays, co-immunoprecipitation, cell migration assay The Journal of cell biology High 22492727
2012 SNX17 interacts with the HPV-16 L2 capsid protein and is essential for papillomavirus infection; this interaction is conserved across multiple PV types, indicating SNX17 is required for a conserved viral entry mechanism. Infection assays with multiple PV types, SNX17 knockdown, interaction studies with L2 protein Journal of virology Medium 23115288
2012 SNX17 acts as a cargo-specific adaptor that binds Jag1a and facilitates retromer-dependent recycling of the Notch ligand Jag1 to the plasma membrane in ligand-expressing cells; inhibition disrupts neurogenesis and pancreas development in zebrafish. Co-immunoprecipitation, zebrafish knockdown/rescue experiments, fluorescence localization Cell regeneration Medium 25408867
2014 SNX17 directly binds KRIT1 through its FERM domain recognizing the second NPXF motif of KRIT1; co-crystal structure at 3.0 Å reveals the interaction is highly similar to the SNX17-P-selectin interaction; site-directed mutagenesis confirms the NPXF2 motif as the major binding site. Co-crystal structure (3.0 Å resolution), site-directed mutagenesis, GST pulldown, binding affinity measurements The Journal of biological chemistry High 25059659
2015 The FERM domain of SNX17 mediates binding and trafficking of TCR and LFA-1 (integrin) to the cell surface; SNX17 colocalizes with TCR at the immune synapse, and SNX17 knockdown reduces surface TCR and LFA-1 expression, TCR recycling, and T cell–APC conjugate formation. siRNA knockdown, immunofluorescence colocalization, flow cytometry for surface receptor expression, TCR recycling assay, domain truncation analysis Journal of immunology Medium 25439
2015 SNX17 FERM domain mediates binding and trafficking of TCR and LFA-1 to the T cell surface, as identified by domain truncation studies. Truncated SNX17 domain expression constructs, immunofluorescence, flow cytometry Journal of immunology Medium 25825439
2018 SNX17 binds SERCA2a protein via its PX (phox-homology) domain, and SNX17 deficiency leads to lysosomal degradation of SERCA2a, intracellular Ca2+ overload, and cardiac arrhythmias; chloroquine (lysosomal inhibitor) prevents SNX17-knockdown-induced SERCA2a reduction. Co-immunoprecipitation with domain mapping, siRNA knockdown, lysosomal inhibitor rescue, Ca2+ imaging, electrocardiography in rat MI model International journal of cardiology Medium 30025651
2019 SNX17 recruits the deubiquitinating enzyme USP9X to antagonize MIB1-mediated ubiquitination and degradation of PCM1 during serum-starvation-induced ciliogenesis; SNX17 deficiency leads to enhanced degradation of both USP9X and PCM1 and disrupts ciliogenesis. Co-immunoprecipitation, siRNA knockdown, ciliogenesis assay, ubiquitination assay Cells Medium 31671755
2019 SNX17 facilitates endocytic sorting of the Kv1.5 potassium channel from the plasma membrane to early endosomes via its FERM domain; SNX17 heterozygous knockout rats show increased membrane Kv1.5 expression, increased IKur, shortened action potential duration, and increased AF susceptibility. SNX17 knockout rat model, patch clamp electrophysiology, optical mapping, immunostaining/confocal, truncated domain expression constructs Circulation. Arrhythmia and electrophysiology Medium 30939909
2020 SNX17 directly interacts with EHD1, a dynamin-like fission GTPase; EHD1 is recruited to endosomal membranes upon LRP1 internalization, SNX17 and EHD1 colocalize on endosomes, and EHD1 depletion causes enlargement of SNX17-containing endosomes, indicating EHD1 mediates fission of SNX17-labeled endosomal carriers. Co-immunoprecipitation, in vitro binding assay, surface rendering/quantification of colocalization volumes, EHD1 siRNA knockdown with endosomal morphology readout The Journal of biological chemistry Medium 32041776
2021 SNX17 interacts with leiomodin-2 (LMOD2) via its C-terminal domain; SNX17 deficiency promotes lysosomal degradation of LMOD2, worsening DOX-induced cardiac systolic dysfunction. Co-immunoprecipitation with domain mapping, siRNA knockdown, lysosomal pathway inhibition, in vivo rat model of cardiotoxicity Pharmacological research Medium 33933636
2022 The C-terminus of SNX17 contains a type III PDZ-binding motif that binds PDLIM family proteins; the co-crystal structure of the PDLIM7 PDZ domain with the SNX17 C-terminus reveals an unconventional perpendicular peptide interaction mediated by electrostatic contacts and a conserved proline-containing loop in PDLIM proteins; the C-terminus of SNX17 is also sufficient for Commander complex interaction. Proteomics, co-crystal structure determination, mutagenesis, biophysical binding assays Structure High 36302387
2023 SNX17 pathway (SNX17-Retriever-CCC-WASH) is required in hippocampal neurons for maintenance of excitatory synapses and structural plasticity during chemical LTP; cLTP drives SNX17 recruitment to synapses in a manner requiring NMDAR activation, CaMKII signaling, Retriever binding, and PI(3)P; SNX17 partly mediates LTP effects through regulation of β1-integrin surface expression. siRNA knockdown in cultured hippocampal neurons, chemical LTP induction, immunofluorescence, spine morphology analysis, surface receptor quantification The Journal of cell biology Medium 37141105
2023 SNX17 interacts with p140Cap (a SRC kinase inhibitor/actin regulator) as identified by GST pulldown and interactome analysis; this interaction is required for dendritic spine maturation, and Snx17 haploinsufficiency in mice impairs synaptic transmission and spine maturation. GST pulldown, interactome/proteomic analysis, Snx17 heterozygous knockout mice, spine morphology, electrophysiology Molecular neurobiology Medium 37704928
2024 SNX17 directly interacts with Retriever through its C-terminal region binding to the VPS35L/VPS26C interface; this interaction is enhanced when SNX17 is bound to cargo (due to disruption of an intramolecular autoinhibitory interaction between the C-terminal region and the cargo-binding pocket); PI(3)P binding by SNX17 also promotes Retriever recruitment independently of cargo. Biophysical assays (binding measurements), structural model-guided mutagenesis, recombinant protein reconstitution with liposomes EMBO reports High 39653850
2024 SNX17 controls antigen internalisation, integrin recycling, actin cytoskeleton organization, and phagosomal maturation in dendritic cells; SNX17 silencing impairs fluid-phase endocytosis, phagocytosis, and T. gondii invasion, and disrupts cross-presentation. siRNA knockdown in dendritic cells, functional endocytosis/phagocytosis assays, integrin recycling assays, actin staining, cross-presentation assay Immunology Medium 39559950
2025 Phosphorylation of SNX17 at serine 38 (Ser38) within the PX domain disrupts SNX17 binding to PI(3)P, impairs its association with early endosomal membranes, inactivates SNX17-dependent cargo recycling, and is part of an autoinhibitory mechanism regulating cargo binding. Phosphomimetic/phosphodead mutagenesis, PI(3)P binding assays, endosomal localization assays, cargo recycling assays in cells The Journal of biological chemistry Medium 40349777
2025 Acidic pH induces a conformational change in the LDLR extracellular domain that promotes interaction between LDLR intracellular domain and SNX17; PCSK9 prevents this acidic pH-induced conformational change, thereby blocking SNX17-LDLR interaction and diverting LDLR to lysosomal degradation; SNX17 knockdown abolishes LDLR recycling and PCSK9-mediated LDLR degradation. SNX17 knockdown in cells and Ldlr KO mice, in vitro and in vivo approaches, conformational change analysis, co-immunoprecipitation, LDLR recycling assays Circulation High 40071387
2025 SNX17 directly interacts with STAT3 and promotes STAT3 phosphorylation in a retromer-dependent manner; the SNX17-retromer complex acts as a platform for IL-6-induced STAT3 activation, leading to c-Myc upregulation and enhanced mitochondrial OXPHOS. Co-immunoprecipitation, STAT3 inhibitor treatment, STAT3 knockdown, retromer knockdown, OXPHOS measurement International journal of biological sciences Low 40303303
2025 SNX17 interacts with the C-terminus of NHE3 (Na+/H+ exchanger 3) via an NPxY motif; mutation of the distal NPxY motif in NHE3 disrupts this interaction, leading to reduced NHE3 expression and increased degradation; SNX17 knockdown reduces NHE3 activity and stability. GST pulldown with NPxY motif mutagenesis, siRNA knockdown, NHE3 activity assay, degradation assay bioRxivpreprint Medium
2025 WIPI2 (a PROPPIN) integrates into Retriever-dependent coat complexes by interacting with both the Commander subunit CCDC93 and SNX17, forming the CROP2 complex; CROP2 is required for endosomal recycling of β1-integrin but not for CROP (Retromer)-dependent cargos. Co-immunoprecipitation, functional recycling assays, genetic depletion of WIPI2 bioRxivpreprint Medium
2025 SNX17-Commander and RAB32-LRMDA-Commander assemblies are mutually exclusive; LRMDA and SNX17 share a common mechanism of Commander association; SNX17-Commander mediates cell surface recycling while RAB32-LRMDA-Commander mediates melanosome biogenesis in melanocytes. Unbiased proteomics, recombinant protein reconstitution, computational modelling, functional assays in human melanocytes bioRxivpreprint Medium
2025 PI(3)P synthesis during chemical LTP drives coordinate recruitment of both the SNX17-Retriever and SNX27-Retromer pathways to endosomes and synaptic sites; preventing PI(3)P synthesis blocks SNX17 synaptic recruitment, decreases cargo recycling, and blocks LTP in cultured neurons and hippocampal slices. PI(3)P synthesis inhibition, live imaging, chemical LTP in hippocampal neurons and slices, cargo recycling assays The Journal of cell biology Medium 40920104
2025 SNX17 promotes lysosomal degradation of VEGFR; in the absence of SNX17, VEGFR accumulates in early endosomes with prolonged activation, promoting angiogenesis; SNX17 knockdown in hindlimb ischemia mice increases blood flow and limb salvage. SNX17 knockdown in cells and hindlimb ischemia mouse model, endosomal localization assays, angiogenesis assays Life sciences Medium 40412610
2026 OCIAD2 binds SNX17 and enhances its association with integrin β1, promoting integrin β1 recycling to lipid raft-enriched plasma membrane regions and preventing its lysosomal degradation; this sustains FAK-PI3K-AKT-mTOR signaling. Co-immunoprecipitation with mass spectrometry, siRNA knockdown, recycling and degradation assays, lipid raft fractionation Advanced science Medium 41655222

Source papers

Stage 0 corpus · 25 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways. The Journal of cell biology 175 22492727
2002 The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. The EMBO journal 116 12169628
2008 Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways. Molecular biology of the cell 55 19005208
2012 SNX17 facilitates infection with diverse papillomavirus types. Journal of virology 47 23115288
2015 SNX17 affects T cell activation by regulating TCR and integrin recycling. Journal of immunology (Baltimore, Md. : 1950) 41 25825439
2025 PCSK9 Promotes LDLR Degradation by Preventing SNX17-Mediated LDLR Recycling. Circulation 33 40071387
2014 Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1). The Journal of biological chemistry 29 25059659
2020 Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery. The Journal of biological chemistry 24 32041776
2019 SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis. Cells 21 31671755
2019 SNX17 (Sorting Nexin 17) Mediates Atrial Fibrillation Onset Through Endocytic Trafficking of the Kv1.5 (Potassium Voltage-Gated Channel Subfamily A Member 5) Channel. Circulation. Arrhythmia and electrophysiology 20 30939909
2018 SNX17 produces anti-arrhythmic effects by preserving functional SERCA2a protein in myocardial infarction. International journal of cardiology 19 30025651
2023 Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity. The Journal of cell biology 15 37141105
2021 LncRNA-SNX17 Promotes HTR-8/SVneo Proliferation and Invasion Through miR-517a/IGF-1 in the Placenta of Diabetic Macrosomia. Reproductive sciences (Thousand Oaks, Calif.) 15 34270000
2012 SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1. Cell regeneration (London, England) 14 25408867
2022 Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins. Structure (London, England : 1993) 13 36302387
2021 SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation. Pharmacological research 10 33933636
2024 Selective cargo and membrane recognition by SNX17 regulates its interaction with Retriever. EMBO reports 8 39653850
2025 SNX17 mediates STAT3 activation to promote hepatocellular carcinoma progression via a retromer dependent mechanism. International journal of biological sciences 5 40303303
2025 Potential Roles of SNX17, Rab11, and Rab5 in LDLR Recycling. Arteriosclerosis, thrombosis, and vascular biology 4 40534554
2023 SNX17 Mediates Dendritic Spine Maturation via p140Cap. Molecular neurobiology 4 37704928
2026 OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17-Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41655222
2025 Phosphorylation of SNX17 impedes activation of Retriever-mediated sorting. The Journal of biological chemistry 0 40349777
2025 SNX17 knockdown improves post-ischemic angiogenesis via blocking lysosomal dependent VEGFR degradation. Life sciences 0 40412610
2025 PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity. The Journal of cell biology 0 40920104
2024 SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells. Immunology 0 39559950

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