Affinage

EHD1

EH domain-containing protein 1 · UniProt Q9H4M9

Length
534 aa
Mass
60.6 kDa
Annotated
2026-06-09
100 papers in source corpus 46 papers cited in narrative 46 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EHD1 is an ATP-dependent membrane-remodeling ATPase that catalyzes fission of tubular endosomal membranes to drive endocytic recycling of internalized cargo back to the plasma membrane (PMID:30403133, PMID:30518883). It belongs to the EH-domain protein family, with an N-terminal nucleotide-binding P-loop, a central coiled-coil, and a C-terminal EH domain, and localizes to transferrin-containing recycling endosomes (PMID:10395801). Mechanistically, ATP-bound EHD1 assembles into membrane-active scaffolds that bulge and thin membrane tubes, with ATP hydrolysis promoting scaffold self-assembly and scission of tubes below ~25 nm radius; both membrane binding and ATP hydrolysis are required for recycling in vivo (PMID:30518883). Recruitment to endosomal membranes depends on its EH domain binding NPF/DPF motifs in partners including Rabenosyn-5, MICAL-L1, Syndapin2, AMPH-1/BIN1, EHBP1, SNAP29, snapin, and Rabankyrin-5 (PMID:15020713, PMID:19864458, PMID:32966336, PMID:19915558, PMID:15247266), together with direct binding to phosphoinositides via Lys-483 and a requirement for phosphatidylserine asymmetry generated by the P4-ATPase ATP8A1 (PMID:17412695, PMID:25595798). EHD1 dimerizes with its paralog EHD4, which delivers it to sorting endosomes (PMID:32966336), and cooperates with retromer/SNX1, SNX17, GRAF1, and cPLA2α at distinct sorting and fission steps (PMID:17868075, PMID:32041776, PMID:25364729, PMID:22456504). Through these activities it recycles diverse cargoes including transferrin receptor, MHC-I, beta1 integrin, GLUT4, and CD59 (PMID:16445686, PMID:12032069, PMID:17284518, PMID:15247266, PMID:20961375), and EHD1 knockout mice confirm delayed recycling exit from the recycling compartment in vivo (PMID:16445686). Beyond recycling, EHD1 is required for early ciliogenesis, where its membrane tubulation generates ciliary vesicles from distal appendage vesicles and where it transports HERC2-bearing centriolar satellites to drive CP110 ubiquitination, and it co-traffics with Smoothened to regulate ciliary Hedgehog signaling (PMID:25686250, PMID:37074924, PMID:26884322). It is also essential for spermatogenesis and skeletal muscle T-tubule maintenance (PMID:20359371, PMID:24440153). A homozygous EHD1 missense variant (p.R398W) that impairs nucleotide binding and oligomerization causes autosomal recessive tubular proteinuria with sensorineural deafness in humans (PMID:35149593).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1999 Medium

    Established EHD1's domain architecture and endosomal localization, framing it as a candidate trafficking protein with both nucleotide-binding and protein-interaction modules.

    Evidence cDNA cloning, domain analysis, and GFP-fusion live imaging in cultured cells

    PMID:10395801

    Open questions at the time
    • No functional mutagenesis of the P-loop or EH domain
    • No biochemical activity demonstrated
  2. 2002 High

    Showed EHD1 associates with and induces Arf6 membrane tubules and promotes MHC-I recycling, with both the P-loop and EH domain required, linking domain integrity to membrane tubulation function.

    Evidence Domain mutagenesis, MHC-I recycling assay, and dominant-negative/active Arf6 in cells

    PMID:12032069

    Open questions at the time
    • Tubulation observed in cells, not reconstituted in vitro
    • Mechanism of nucleotide action unresolved
  3. 2004 High

    Defined the EH-domain/NPF-motif logic of EHD1 recruitment through Rabenosyn-5, EHBP1, and SNAP29/syndapin II, and placed EHD1 in an ordered recycling pathway via RNAi epistasis.

    Evidence GST pulldown, mass spectrometry, RNAi epistasis, and cargo recycling assays (transferrin, MHC-I, GLUT4)

    PMID:15020713 PMID:15247266 PMID:15371016

    Open questions at the time
    • How multiple mutually exclusive NPF partners are spatially coordinated unclear
    • No structural basis for partner selectivity
  4. 2006 High

    Validated the recycling role in vivo, confirming EHD1 governs cargo exit from the recycling compartment in a whole animal.

    Evidence Ehd1 knockout mice with transferrin recycling assay in MEFs

    PMID:16445686

    Open questions at the time
    • Did not address tissue-specific cargo dependencies
    • Molecular step controlled remained inferential
  5. 2007 High

    Expanded EHD1's cargo and pathway scope to retromer-dependent retrograde traffic, beta1 integrin/focal adhesion turnover, and cholesterol homeostasis, and mapped direct phosphoinositide binding to Lys-483 of the EH domain.

    Evidence Knockout MEFs with rescue, RNAi, retrograde trafficking assays, NMR structure of the EH domain, and lipid-binding/mutagenesis assays

    PMID:17284518 PMID:17412695 PMID:17451452 PMID:17868075 PMID:17899392

    Open questions at the time
    • Relationship between lipid binding and NPF-partner binding in recruitment not integrated
    • Full-length structure not solved
  6. 2009 High

    Provided the first reconstitution evidence that EHD1/RME-1 together with an NPF partner (AMPH-1/BIN1) tubulates membranes, and identified MICAL-L1 as the tubular recycling endosome recruiter linking EHD1 to Rab8a.

    Evidence C. elegans genetics, in vitro tubulation with purified proteins, and Co-IP/RNAi in human cells (MICAL-L1)

    PMID:19174465 PMID:19864458 PMID:19915558

    Open questions at the time
    • Whether tubulation and fission are separable activities not resolved
    • ATP requirement not yet directly tied to scission
  7. 2010 Medium

    Broadened EHD1 into tissue-level physiology—spermatogenesis, neuronal cargo (NgCAM) trafficking via EHD1-EHD4 balance, GPI-AP (CD59) sorting, exocytosis via snapin, and myoblast fusion via Fer1L5—revealing context-specific roles and paralog interplay.

    Evidence Conditional knockout mice, shRNA/overexpression with endocytosis assays, Co-IP, direct binding, and exocytosis electrophysiology

    PMID:20359371 PMID:20463227 PMID:20696250 PMID:20961375 PMID:21147988 PMID:21177873

    Open questions at the time
    • Mechanistic basis for neuron-specific effects unclear
    • Most interactions from single labs without reciprocal in vitro reconstitution
  8. 2012 Medium

    Demonstrated cargo-selective retrograde roles and identified Rabankyrin-5 and cPLA2α as cooperating factors, linking EHD1 fission to lipid composition of GPI-AP endosomes.

    Evidence Multiple binding assays including ITC (Rabankyrin-5), proximity ligation (cPLA2α), RNAi, and selective cargo trafficking readouts

    PMID:22284051 PMID:22456504 PMID:22540229

    Open questions at the time
    • How EHD1 discriminates among retrograde cargoes unresolved
    • Direct enzymatic role of EHD1 vs partner lipid modification not separated
  9. 2014 Medium

    Tied EHD1 fission to GRAF1-dependent vesiculation and to Src recycling, cytokinesis, and T-tubule maintenance in muscle, requiring the ATPase domain for tubule formation.

    Evidence Semi-permeabilized vesiculation assay with purified proteins, RNAi, EHD1-null mice, EM, and ATPase-domain mutants

    PMID:24440153 PMID:24481818 PMID:25287187 PMID:25364729

    Open questions at the time
    • GRAF1/EHD1 synergy mechanism at molecular detail unclear
    • T-tubule defect causality vs secondary effects not fully resolved
  10. 2015 High

    Established EHD1's ciliogenesis role through membrane tubulation generating ciliary vesicles, and showed phosphatidylserine flipping by ATP8A1 is a prerequisite for EHD1 membrane recruitment and tube fission.

    Evidence siRNA, live imaging, EM, Rab11/Rab8 manipulation (ciliogenesis); ATP8A1 knockdown with PS distribution and EHD1 localization assays

    PMID:25595798 PMID:25686250

    Open questions at the time
    • How PS asymmetry and Lys-483 phosphoinositide binding jointly govern recruitment unresolved
    • Coupling of ciliary and recycling functions unclear
  11. 2016 High

    Identified EHD1 as a developmental regulator of ciliary Hedgehog signaling through direct co-trafficking of Smoothened into primary cilia, with knockout causing embryonic neural tube defects.

    Evidence EHD1 knockout mice, Co-IP (EHD1-Smoothened), ciliary trafficking analysis, and SHH pathway readouts

    PMID:26884322

    Open questions at the time
    • Whether EHD1 transports Smoothened by direct vesicle fission or as a chaperone unclear
    • Strain-specific severity differences not mechanistically explained
  12. 2018 High

    Resolved the core biochemistry: EHD1 is an ATP-dependent membrane fission catalyst whose ATP-bound scaffolds bulge tubes and whose hydrolysis drives constriction and scission below ~25 nm, mechanistically distinguishing it from GTP-dependent dynamin.

    Evidence Supported membrane tube fission assays with purified protein, molecular dynamics, and C. elegans cross-complementation with N-terminal deletion mutants

    PMID:30403133 PMID:30518883

    Open questions at the time
    • High-resolution structure of the assembled scaffold not determined
    • Coupling of partner binding to scaffold nucleation in vivo not reconstituted
  13. 2020 Medium

    Refined recruitment logic by showing EHD4 dimerization delivers EHD1 to sorting endosomes and that SNX17- and Eps15-linked cargo internalization recruits EHD1, extending its fission role to LRP1 and Cx43 trafficking.

    Evidence Co-IP, siRNA/shRNA/CRISPR knockdown, endosomal size quantification, and recruitment/recycling assays

    PMID:32041776 PMID:32138615 PMID:32966336

    Open questions at the time
    • Hierarchy between EHD4 dimerization and individual NPF partners not ordered
    • Cardiac Cx43 effects from single lab
  14. 2023 High

    Defined a transport-based ciliogenesis mechanism in which EHD1 moves HERC2-bearing centriolar satellites to drive CP110 ubiquitination and removal, and provided human disease evidence that nucleotide-binding/oligomerization-defective EHD1 causes renal tubular proteinuria with deafness.

    Evidence Co-IP, ubiquitination assay, satellite transport imaging (ciliogenesis); human genetics with knockout/knockin mice and zebrafish (disease)

    PMID:31615969 PMID:35149593 PMID:37074924

    Open questions at the time
    • How EHD1 mechanically powers satellite movement vs vesicle fission unclear
    • Disease variant effects on specific cargo recycling steps incompletely mapped
  15. 2025 Medium

    Extended EHD1 recycling control to oncogenic and immunomodulatory cargo (IGF-1R, PD-L1) and revealed transcriptional/post-transcriptional regulation of EHD1 itself via c-Myc and m6A/YTHDF1.

    Evidence shRNA/CRISPR with RTK and surface-expression assays, Co-IP, recycling assays, and MeRIP/RIP m6A analysis

    PMID:34217785 PMID:37474760 PMID:40703029

    Open questions at the time
    • Whether cargo selection in cancer reflects altered partner expression unclear
    • Single-lab functional readouts for each cargo

Open questions

Synthesis pass · forward-looking unresolved questions
  • How EHD1 scaffolds integrate multiple competing NPF-partner inputs, lipid cues (phosphoinositide and phosphatidylserine), and paralog dimerization into spatially defined fission events at distinct endosomal subdomains remains unresolved.
  • No high-resolution structure of the membrane-bound EHD1 scaffold
  • No unified model reconciling cargo specificity with a generic fission machine
  • Quantitative ordering of recruitment determinants in vivo lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 2 GO:0016787 hydrolase activity 2 GO:0060090 molecular adaptor activity 2 GO:0140657 ATP-dependent activity 2 GO:0005198 structural molecule activity 1
Localization
GO:0005768 endosome 4 GO:0005815 microtubule organizing center 2 GO:0005886 plasma membrane 2 GO:0005929 cilium 2 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 5 R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-9609507 Protein localization 3 R-HSA-1852241 Organelle biogenesis and maintenance 2
Partners
BIN1EHBP1EHD3EHD4MICAL-L1RABENOSYN-5SNAP29SNX17

Evidence

Reading pass · 46 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 EHD1 was identified as a member of the EH-domain-containing protein family, with an EH domain at its C-terminus (including an EF Ca2+-binding motif), a central coiled-coil structure, and a nucleotide-binding consensus site (P-loop) at its N-terminus. As a GFP fusion protein, EHD1 localizes to transferrin-containing endocytic vesicles in cultured cells. cDNA cloning, domain analysis, GFP fusion protein live-cell imaging Genomics Medium 10395801
2001 EHD1 interacts directly with SNAP29 (GS32) via its EH domain and with alpha-adaptin of AP-2, forms complexes with IGF-1R in endocytic vesicles, and co-localizes intracellularly with IGF-1R after IGF-1 stimulation. Overexpression of EHD1 suppresses IGF-1-mediated MAPK and Akt phosphorylation, establishing EHD1 as a negative regulator of IGF-1 signaling. Co-immunoprecipitation, co-localization immunofluorescence, overexpression with downstream signaling readout (MAPK/Akt phosphorylation) The Journal of biological chemistry Medium 11423532
2002 EHD1 associates with Arf6-containing long membrane tubules and induces tubule formation. Mutations in the N-terminal P-loop domain or deletion of the C-terminal EH domain prevent tubule association and tubule induction. EHD1-associated tubules contain MHC-I molecules trafficked through the Arf6 clathrin-independent pathway, and EHD1 overexpression enhances MHC-I recycling to the plasma membrane. Tubule formation requires nucleotide cycling on Arf6 and intact microtubules. Transgenic tagged EHD1 expression, domain deletion/point mutation analysis, MHC-I recycling assay, immunofluorescence co-localization, Arf6 dominant-negative/active mutants The EMBO journal High 12032069
2002 EHD1 and EHD3 interact with each other as shown by yeast two-hybrid assay and confirmed by co-immunoprecipitation. The N-terminal domain of EHD proteins is responsible for tubular vs. vesicular localization, and both N-terminal and C-terminal (EH) domains of EHD3 are required for its tubular localization. Co-expression of EHD1 and EHD3 results in their colocalization on microtubule-dependent tubular structures. Yeast two-hybrid, co-immunoprecipitation, GFP fusion proteins, chimeric domain swapping, fluorescence microscopy Traffic (Copenhagen, Denmark) High 12121420
2004 EHD1 directly interacts with Rabenosyn-5 (a Rab4/Rab5 effector) via the EH domain of EHD1 and the first two NPF motifs of Rabenosyn-5. RNAi depletion of EHD1 delays recycling of transferrin and MHC-I, causing cargo accumulation in a compact juxtanuclear compartment. Simultaneous RNAi of both proteins phenocopies Rabenosyn-5 depletion alone, establishing that Rabenosyn-5 acts upstream of EHD1 in endocytic recycling from early endosomes to the endosomal recycling compartment and back to the plasma membrane. GST pulldown from brain cytosol, mass spectrometry identification, co-immunoprecipitation, RNAi knockdown, recycling assays, immunofluorescence Molecular biology of the cell High 15020713
2004 EHD1 interacts through its EH domain with EHBP1, and both EHD1 and EHBP1 are required for perinuclear localization of GLUT4-containing membranes and insulin-stimulated recycling of GLUT4 to the plasma membrane in adipocytes. A dominant-negative EHD1 lacking the EH domain (ΔEH-EHD1) disperses perinuclear GLUT4 and inhibits GLUT4 translocation. Co-immunoprecipitation, dominant-negative overexpression, siRNA knockdown, immunofluorescence co-localization, glucose transport assay The Journal of biological chemistry High 15247266
2004 EHD1 interacts with GS32/SNAP-29 via the EH domain binding to the N-terminal NPF-containing region of GS32, and with syndapin II via the EH domain binding to NPF repeats. These two interactions are mutually exclusive. Both interactions were confirmed by co-immunoprecipitation from cell extracts. GST pulldown, co-immunoprecipitation, competition binding assay Molecular membrane biology Medium 15371016
2006 EHD1 knockout mice show delayed recycling of transferrin to the plasma membrane with accumulation in the endocytic recycling compartment, confirming the role of EHD1 in exit of membrane proteins from recycling endosomes in vivo. Ehd1 knockout mouse model, transferrin recycling assay in embryonic fibroblasts Traffic (Copenhagen, Denmark) High 16445686
2007 EHD1 directly and preferentially binds phosphatidylinositols (preferring PI with a phosphate at position 3) via a positively charged lysine residue (Lys-483) in the third helix of the EH domain, on the opposite face from the NPF-binding pocket. This phospholipid-binding activity was characterized by 2D NMR analysis. Lipid-binding assay (dot blot/overlay), 2D NMR analysis, site-directed mutagenesis (K483 substitution) The Journal of biological chemistry High 17412695
2007 EHD1 interacts with retromer and co-localizes with retromer on tubular/vesicular endosomes. P-loop mutation of EHD1 exerts a dominant-negative effect on retromer localization and endosome-to-Golgi retrieval. RNAi-mediated EHD1 depletion destabilizes SNX1-positive tubules and inhibits endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor. Comparative proteomics, co-immunoprecipitation, P-loop dominant-negative mutation, RNAi knockdown, retrograde trafficking assay Traffic (Copenhagen, Denmark) High 17868075
2007 EHD1 regulates beta1 integrin recycling from a transferrin-containing endocytic recycling compartment to the plasma membrane. EHD1 knockout MEFs display lower surface beta1 integrin but higher activated beta1 integrin, larger focal adhesions (slower disassembly), and impaired cell spreading and migration on fibronectin. These defects are rescued by re-introduction of wild-type EHD1. EHD1 knockout MEFs, RNAi knockdown, integrin recycling assay, focal adhesion analysis, cell migration and spreading assay Journal of cell science High 17284518
2007 Myosin Vb interacts with Rab8a (confirmed by yeast two-hybrid and FRET), and Rab8a co-localizes with Myosin Vb on a tubular network containing EHD1 and EHD3 that is distinct from the Rab11a compartment, defining a separate non-clathrin recycling pathway. Yeast two-hybrid, FRET, fluorescence microscopy co-localization Molecular biology of the cell Medium 17507647
2007 The solution NMR structure of the C-terminal 133 residues of EHD1 (including the EH domain) was solved. While overall resembling the second EH domain of Eps15, the EHD1 EH domain has significant differences in surface charge and the NPF/DPF tripeptide-binding pocket. NMR spectroscopy, solution structure determination Journal of biomolecular NMR High 17899392
2007 EHD1 depletion in EHD1 knockout MEFs reduces cholesterol uptake via LDL receptor, results in reduced esterified and free cholesterol levels, and smaller lipid droplets. These phenotypes are rescued by wild-type but not dysfunctional EHD1, implicating EHD1 in LDL receptor internalization and cholesterol homeostasis. EHD1 knockout MEFs, siRNA, cholesterol measurement, lipid droplet analysis, LDL receptor internalization assay, rescue with wild-type EHD1 Biochemical and biophysical research communications Medium 17451452
2008 EHD1 undergoes serine phosphorylation, enhanced by serum stimulation, with PKC identified as one of the relevant kinases. Inhibitors of clathrin-mediated endocytosis decrease EHD1 phosphorylation, suggesting phosphorylation occurs between early endosomes and the endocytic recycling compartment. Phosphorylation assay, serum stimulation, PKC inhibitors, endocytosis inhibitors, immunoprecipitation Cellular & molecular biology letters Medium 18661112
2009 C. elegans AMPH-1 (Amphiphysin/BIN1 ortholog) co-localizes with RME-1 (EHD1 ortholog) on recycling endosomes; AMPH-1 deletion mutants show defective recycling endosome morphology and function. AMPH-1 NPF motifs bind to the RME-1 EH domain to promote cargo recycling. Human BIN1 is required for EHD1-regulated endocytic recycling. In vitro, purified AMPH-1 and RME-1 together produce short coated membrane tubules distinct from those made by either protein alone. In vivo C. elegans genetics, co-localization, in vitro membrane tubulation reconstitution with purified proteins, EH-domain binding assay Nature cell biology High 19915558
2009 MICAL-L1 interacts with EHD1 via its NPF motifs (binding the EH domain of EHD1), recruits EHD1 to long tubular recycling endosomes, and links EHD1 and Rab8a on these structures. MICAL-L1 depletion causes loss of EHD1 and Rab8a from tubular membranes and impairs endocytic recycling of transferrin and integrin receptors. Co-immunoprecipitation, siRNA knockdown, in vitro binding assay, live-cell imaging, immunofluorescence co-localization Molecular biology of the cell High 19864458
2010 EHD1 is essential for spermatogenesis; EHD1 knockout male mice are infertile with abnormal acrosomal development, clumping of acrosomes, misaligned spermatids, absence of mature spermatozoa, and abnormal phagocytosis of elongated spermatids by Sertoli cells. Cre/loxP conditional knockout mice, histopathology, light and electron microscopy, in situ hybridization, immunohistochemistry BMC developmental biology High 20359371
2010 EHD1 binds directly to the second C2 domain of Fer1L5, and reduction of EHD1 inhibits myoblast fusion and impairs Fer1L5 translocation to the plasma membrane. Direct protein binding assay, siRNA knockdown, myoblast fusion assay, membrane localization analysis The Journal of biological chemistry Medium 21177873
2010 Overexpression of EHD1 impairs L1/NgCAM endocytosis in neurons (but not in fibroblasts), while downregulation of EHD1 causes increased endosomal accumulation of NgCAM. Balanced EHD1:EHD4 levels are required for NgCAM endocytosis; EHD1 oligomerization is required for the endocytosis defect. An endogenous EHD1-EHD4 complex was identified. shRNA knockdown, overexpression, endocytosis assay, co-immunoprecipitation, live imaging The Journal of neuroscience Medium 20463227
2010 In neurons, EHD1 functions primarily at EEA1-positive early endosomes. Downregulation of EHD1 delays exit of L1/NgCAM from EEA1-positive endosomes, impairing axonal targeting. EHD1 stably associates with endosomal membranes during maturation into EEA1-positive compartments. shRNA knockdown, live imaging, immunofluorescence, endosomal maturation tracking The Journal of neuroscience Medium 21147988
2010 EHD1 interacts with snapin via its EH domain, competes with SNAP-25 for overlapping binding sites on the C-terminus of snapin, and affects synaptotagmin-1 coupling to the SNARE complex. EHD1 overexpression reduces depolarization-induced exocytosis in PC12 cells; this effect requires the EH domain since N-terminal EHD1 (unable to bind snapin) does not reduce exocytosis. Yeast two-hybrid, EH domain binding assay, electrophysiology/exocytosis assay, SNARE complex analysis Molecular and cellular neurosciences Medium 20696250
2010 EHD1 depletion causes rapid Rab5-independent coalescence of CD59 (a GPI-AP) in the endocytic recycling compartment region, revealing a role for EHD1 in regulating CD59 trafficking from pre-sorting endosomes to the ERC in a PKC-dependent manner. siRNA knockdown, Arf6-Q67L dominant-active mutant, PKC inhibitor treatment, immunofluorescence Traffic (Copenhagen, Denmark) Medium 20961375
2012 EHD1 is required for retrograde transport of Shiga toxin B from recycling endosomes to the TGN, while CI-M6PR retrograde trafficking was not significantly dependent on EHD1, demonstrating cargo-selective roles in retrograde traffic. EHD1 knockdown, retrograde trafficking assay with Shiga toxin B and CD8-CI-M6PR, immunofluorescence Traffic (Copenhagen, Denmark) Medium 22540229
2012 Rabankyrin-5 interacts with EHD1 via the EH domain binding to the NPFED motif of Rank-5, confirmed by GST-pulldown, yeast two-hybrid, isothermal calorimetry, and co-immunoprecipitation. Rank-5 also interacts with retromer component Vps26. Depletion of Rank-5 causes mislocalization of Vps26, impairs mannose 6-phosphate receptor retrieval, and depletion of either Rank-5 or EHD1 impairs VSV-G secretion. GST-pulldown, yeast two-hybrid, isothermal calorimetry, co-immunoprecipitation, siRNA knockdown, trafficking assays Traffic (Copenhagen, Denmark) High 22284051
2012 cPLA2α and EHD1 interact in vivo (co-proximity <40 nm, co-immunoprecipitation). Depletion of cPLA2α induces hypertubulation of CD59-containing endosomes, and depletion of EHD1 similarly induces hypertubulation, while lysophospholipid accumulation causes vesiculation. Results indicate cPLA2α and EHD1 cooperate in vesiculation of GPI-AP-containing endosomes. Co-immunoprecipitation, proximity ligation assay (<40 nm), siRNA knockdown, lipid manipulation, immunofluorescence morphology Molecular biology of the cell Medium 22456504
2014 GRAF1 forms a complex with EHD1 and MICAL-L1. GRAF1 overexpression causes vesiculation of MICAL-L1-containing tubular recycling endosomes, while GRAF1 depletion leads to impaired TRE vesiculation and delayed receptor recycling. Co-addition of purified EHD1 and GRAF1 in a semi-permeabilized cell vesiculation assay produces synergistic tubular recycling endosome vesiculation. Co-immunoprecipitation, siRNA knockdown, overexpression, semi-permeabilized cell vesiculation assay with purified proteins, immunofluorescence Frontiers in cell and developmental biology Medium 25364729
2014 EHD1 depletion impairs receptor recycling and mislocalizes caveolin-3 and Fer1L5 in myoblasts, reduces myoblast fusion, and causes smaller muscles in vivo. EHD1 localizes to the T-tubule in skeletal muscle, and its loss leads to T-tubule overgrowth with excess vesicle accumulation. EHD1 ATPase domain is required for tubule formation in myoblasts, and EHD1 regulates BIN1-induced tubule formation. EHD1-null mice, myoblast fusion assay, T-tubule morphology analysis by electron microscopy, ATPase domain mutants, BIN1 tubulation assay Developmental biology High 24440153
2014 MICAL-L1 and EHD1 are required for Src activation and transport to the cell periphery in response to growth factor and integrin stimulation. MICAL-L1-mediated recruitment of EHD1 to Src-containing recycling endosomes is required for release of Src from the perinuclear endocytic recycling compartment. siRNA knockdown, Src kinase activation assay, immunofluorescence localization, co-immunoprecipitation, migration/spreading assay Journal of cell science Medium 24481818
2014 Depletion of EHD1 or MICAL-L1 results in increased numbers of bi-nucleated cells due to impaired recycling endosome transport during late cytokinesis. MICAL-L1 but not EHD1 depletion also causes aberrant chromosome alignment and lagging chromosomes, indicating an EHD1-independent mitotic role for MICAL-L1. Both proteins influence microtubule dynamics during mitosis. siRNA knockdown, bi-nucleation quantification, live-cell imaging of cytokinesis, chromosome analysis Traffic (Copenhagen, Denmark) Medium 25287187
2015 EHD1 and EHD3 function in early ciliogenesis by promoting membrane tubulation and ciliary vesicle formation from distal appendage vesicles (DAVs) at the mother centriole, working in association with the Rab11-Rab8 cascade. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation drives mother centriole to basal body transformation and recruits transition zone proteins and IFT20. SNAP29 (an EHD1-binding protein and SNARE regulator) is also required for DAV-mediated ciliary vesicle assembly. siRNA knockdown, live-cell imaging, electron microscopy, immunofluorescence localization, Rab11/Rab8 cascade manipulation Nature cell biology High 25686250
2015 PS flipping by the P4-ATPase ATP8A1 is required for EHD1 recruitment to recycling endosomes. Depletion of ATP8A1 impairs PS asymmetry in recycling endosomes, dissociates EHD1 from recycling endosomes, and generates aberrant endosomal tubules resistant to fission. EHD1 did not show membrane localization in cells defective in PS synthesis. siRNA knockdown of ATP8A1, PS distribution analysis, EHD1 localization assay, endosomal tubule morphology analysis The EMBO journal High 25595798
2016 EHD1 knockout in mice on a B6 background causes embryonic lethality at mid-gestation with failure of neural tube closure, axial turning, and neural tube patterning. Ehd1-null embryos display short stubby cilia on neuroepithelium at E9.5. Loss of EHD1 deregulates ciliary SHH signaling with downregulation of GLI3 repressor formation and increase in SHH-specified ventral neuronal markers. EHD1 co-localizes with and directly binds Smoothened in primary cilia upon ligand stimulation, co-trafficking with Smoothened into developing primary cilia. EHD1 knockout mice, immunofluorescence, co-immunoprecipitation (EHD1-Smoothened), cilia morphology analysis, SHH pathway readouts Scientific reports High 26884322
2018 EHD1 forms membrane-active scaffolds when ATP-bound that bulge tubular membranes. ATP hydrolysis promotes scaffold self-assembly, causing extension and thinning of membrane tube intermediate regions, leading to scission of tubes below 25 nm radius. Deletion of N-terminal residues causes defects in stable scaffolding, scission, and endocytic recycling. Cross-complementation assays in C. elegans confirm that both membrane binding and ATP hydrolysis activities are necessary for endocytic recycling. In vitro membrane tubulation with purified EHD1, supported membrane tubes assay, molecular dynamics simulation, C. elegans cross-complementation, N-terminal deletion mutants Nature communications High 30518883
2018 EHD1 is identified as an ATP-dependent membrane fission catalyst, distinct from GTP-dependent dynamin. In a screen using supported membrane tubes monitored by microscopy, EHD1 drives ATP-dependent membrane tube scission. Supported membrane tube fission assay, biochemical fractionation, mass spectrometry identification Biochemistry High 30403133
2019 MICAL-L1 recruits EHD1 to basal bodies to promote ciliogenesis. MICAL-L1 knockdown prevents CP110 removal from the mother centriole (similar to EHD1 knockdown) and prevents EHD1 localization to basal bodies. MICAL-L1 directly interacts with α-tubulin-β-tubulin heterodimers and γ-tubulin at centrosomes, suggesting centriolar tubulin anchors MICAL-L1 which then recruits EHD1. siRNA knockdown, mass spectrometry, direct binding assay (MICAL-L1 with tubulins), immunofluorescence localization, co-localization analysis Journal of cell science Medium 31615969
2020 EHD4 preferentially dimerizes with EHD1 and is required for the recruitment of EHD1 to sorting endosomes. EHD4 knockdown (by siRNA, shRNA, or CRISPR/Cas9) leads to impaired EHD1 SE-recruitment and enlarged sorting endosomes. EHD1 binding partners Rabenosyn-5, Syndapin2, and MICAL-L1 (NPF motif-containing proteins localized to sorting endosomes) are each required for EHD1 recruitment to sorting endosomes; knockdown of any one leads to enlarged sorting endosomes. Co-immunoprecipitation (EHD4-EHD1 dimerization), siRNA/shRNA/CRISPR knockdown, endosomal size quantification, EHD1 localization assay PloS one Medium 32966336
2020 SNX17 directly interacts with EHD1. Internalization of LRP1 (a SNX17 cargo) recruits cytoplasmic EHD1 to endosomal membranes. EHD1 depletion results in larger SNX17-containing endosomes, suggesting impaired EHD1-mediated endosomal fission downstream of SNX17-dependent cargo sorting. Co-immunoprecipitation, in vitro binding assay, endosomal size quantification, EHD1 recruitment assay The Journal of biological chemistry Medium 32041776
2020 EHD1 knockdown impairs Cx43 internalization in cardiomyocytes, preserving gap junction-intercellular coupling. EHD1 interaction with Cx43 is mediated by Eps15 and is promoted by Cx43 phosphorylation and ubiquitination. EHD1 overexpression accelerates Cx43 internalization and exacerbates ischemia-induced Cx43 lateralization. siRNA knockdown, overexpression, co-immunoprecipitation, gap junction coupling assay, immunofluorescence Circulation research Medium 32138615
2022 Coronin2A (CORO2A) is a novel EHD1 interaction partner. CORO2A localizes to endosomal structures as well as stress fibers. CORO2A depletion impairs recycling of clathrin-independent cargo and causes enlarged endosomes, supporting a role in EHD1-mediated endosomal fission. CORO2A depletion decreases internalization of clathrin-dependent cargo but does not affect uptake of clathrin-independent cargo. Co-immunoprecipitation, siRNA knockdown, cargo recycling and uptake assays, immunofluorescence Molecular biology of the cell Medium 35921168
2022 A homozygous missense variant (p.R398W) in EHD1 causes autosomal recessive tubular proteinuria and sensorineural deafness in humans. In silico analysis predicts R398W destabilizes the protein and impairs nucleotide binding, leading to defective EHD1 oligomerization and membrane remodeling. Ehd1 knockout and knockin mice recapitulate the renal (impaired receptor-mediated endocytosis in proximal tubules) and auditory phenotypes. Ciliogenesis appeared unaffected in patients and mouse models. Human genetics (homozygous missense), knockout and knockin mouse models, zebrafish model, receptor-mediated endocytosis assay, in silico structural analysis Journal of the American Society of Nephrology High 35149593
2023 EHD1 promotes CP110 ubiquitination during ciliogenesis by transporting centriolar satellites (containing the E3 ubiquitin ligase HERC2) to the mother centriole. HERC2 and MIB1 were identified as E3 ligases that interact with and ubiquitinate CP110. HERC2 is required for ciliogenesis and localizes to centriolar satellites. EHD1 controls centriolar satellite movement to deliver HERC2 for CP110 ubiquitination and degradation. co-immunoprecipitation, siRNA knockdown, ubiquitination assay, centriolar satellite transport imaging, immunofluorescence EMBO reports High 37074924
2023 EHD1 is required for endocytic recycling and Golgi-to-plasma membrane traffic of IGF-1R to maintain IGF-1R surface expression and downstream signaling in Ewing sarcoma cells. EHD1 overexpression-dependent oncogenic traits require IGF-1R expression and kinase activity, establishing RTK traffic regulation as a proximal oncogenic mechanism. shRNA knockdown, CRISPR knockout, mouse Ehd1 rescue, RTK antibody array, IGF-1R surface expression and signaling assays Communications biology Medium 37474760
2009 Drosophila Past1 (ortholog of EHD1) is involved in endocytosis; Past1 mutant garland cells show markedly decreased fluorescent avidin endocytosis. Past1 mutants are infertile, temperature-sensitive, and die prematurely. Past1 genetically interacts with Notch signaling pathway components. P-element excision mutants, fluorescent endocytosis assay, genetic interaction analysis Journal of cell science Medium 19174465
2021 EHD1 contributes to 14-3-3ζ dimerization and subsequent β-catenin/c-Myc signaling activation in NSCLC cells. Co-IP, native gel electrophoresis, and immunoblotting showed the EHD1/14-3-3ζ interaction. This activates a positive feedback circuit: c-Myc binds the EHD1 promoter and transcriptionally activates EHD1. Co-immunoprecipitation, native gel electrophoresis, ChIP analysis of EHD1 promoter, siRNA knockdown, Wnt pathway inhibitor Cancer letters Medium 34217785
2025 EHD1 interacts with PD-L1 protein (confirmed by molecular docking, immunofluorescence, and immunoprecipitation) and promotes PD-L1 endosomal recycling back to the cell surface. EHD1 knockdown inhibits PD-L1 recycling and promotes its lysosomal degradation. EHD1 mRNA carries m6A modification recognized by YTHDF1, which enhances EHD1 mRNA stability in an m6A-dependent manner. Molecular docking, co-immunoprecipitation, immunofluorescence, receptor internalization and recycling assays, MeRIP-qPCR, RIP assay, m6A-binding site mutation Cancer communications Medium 40703029

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. The EMBO journal 265 12032069
2015 Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nature cell biology 211 25686250
2008 Ehd2, a rice ortholog of the maize INDETERMINATE1 gene, promotes flowering by up-regulating Ehd1. Plant physiology 200 18790997
2016 Hd1,a CONSTANS ortholog in rice, functions as an Ehd1 repressor through interaction with monocot-specific CCT-domain protein Ghd7. The Plant journal : for cell and molecular biology 179 26991872
2007 OsMADS51 is a short-day flowering promoter that functions upstream of Ehd1, OsMADS14, and Hd3a. Plant physiology 172 17951465
2009 AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling. Nature cell biology 168 19915558
2009 MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling. Molecular biology of the cell 151 19864458
2010 OsCOL4 is a constitutive flowering repressor upstream of Ehd1 and downstream of OsphyB. The Plant journal : for cell and molecular biology 146 20409004
2007 Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Molecular biology of the cell 141 17507647
2004 Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane. Molecular biology of the cell 122 15020713
2008 Rice Indeterminate 1 (OsId1) is necessary for the expression of Ehd1 (Early heading date 1) regardless of photoperiod. The Plant journal : for cell and molecular biology 116 18774969
2015 Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase. The EMBO journal 114 25595798
2007 EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval. Traffic (Copenhagen, Denmark) 112 17868075
2007 EHD1 regulates beta1 integrin endosomal transport: effects on focal adhesions, cell spreading and migration. Journal of cell science 110 17284518
2001 Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. The Journal of biological chemistry 108 11423532
2004 Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. The Journal of biological chemistry 103 15247266
2014 Rice miR172 induces flowering by suppressing OsIDS1 and SNB, two AP2 genes that negatively regulate expression of Ehd1 and florigens. Rice (New York, N.Y.) 83 26224560
1999 EHD1--an EH-domain-containing protein with a specific expression pattern. Genomics 78 10395801
2016 Homodimerization of Ehd1 Is Required to Induce Flowering in Rice. Plant physiology 76 26864016
2002 EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1. Traffic (Copenhagen, Denmark) 74 12121420
2006 Recycling to the plasma membrane is delayed in EHD1 knockout mice. Traffic (Copenhagen, Denmark) 69 16445686
2007 Ectopic expression of OsLFL1 in rice represses Ehd1 by binding on its promoter. Biochemical and biophysical research communications 56 17592727
2020 EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases. Circulation research 55 32138615
2016 A CONSTANS-like transcriptional activator, OsCOL13, functions as a negative regulator of flowering downstream of OsphyB and upstream of Ehd1 in rice. Plant molecular biology 55 27405463
2019 EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure. EBioMedicine 54 31707150
2012 Retromer guides STxB and CD8-M6PR from early to recycling endosomes, EHD1 guides STxB from recycling endosome to Golgi. Traffic (Copenhagen, Denmark) 53 22540229
2007 EHD1 and Eps15 interact with phosphatidylinositols via their Eps15 homology domains. The Journal of biological chemistry 53 17412695
2010 The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC developmental biology 51 20359371
2010 Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion. The Journal of biological chemistry 51 21177873
2018 SIP1 participates in regulation of flowering time in rice by recruiting OsTrx1 to Ehd1. The New phytologist 50 29611871
2018 ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling. Nature communications 50 30518883
2012 Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Traffic (Copenhagen, Denmark) 50 22284051
2019 Targeting the IL-1β/EHD1/TUBB3 axis overcomes resistance to EGFR-TKI in NSCLC. Oncogene 47 31740781
2018 OsMFT1 increases spikelets per panicle and delays heading date in rice by suppressing Ehd1, FZP and SEPALLATA-like genes. Journal of experimental botany 47 30124949
2012 cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes. Molecular biology of the cell 45 22456504
2016 Hd3a, RFT1 and Ehd1 integrate photoperiodic and drought stress signals to delay the floral transition in rice. Plant, cell & environment 44 27111837
2014 EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development. Developmental biology 44 24440153
2011 Heading date gene, dth3 controlled late flowering in O. Glaberrima Steud. by down-regulating Ehd1. Plant cell reports 43 21830130
2007 EHD1 regulates cholesterol homeostasis and lipid droplet storage. Biochemical and biophysical research communications 41 17451652
2004 Mutually exclusive interactions of EHD1 with GS32 and syndapin II. Molecular membrane biology 38 15371016
2014 GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation. Frontiers in cell and developmental biology 37 25364729
2017 OsLBD37 and OsLBD38, two class II type LBD proteins, are involved in the regulation of heading date by controlling the expression of Ehd1 in rice. Biochemical and biophysical research communications 35 28342864
2007 EH domain of EHD1. Journal of biomolecular NMR 35 17899392
2010 Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting. The Journal of neuroscience : the official journal of the Society for Neuroscience 33 20463227
2016 Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development. Scientific reports 32 26884322
2015 Both Hd1 and Ehd1 are important for artificial selection of flowering time in cultivated rice. Plant science : an international journal of experimental plant biology 32 26566836
2010 Neuronal early endosomes require EHD1 for L1/NgCAM trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience 30 21147988
2022 A novel EHD1/CD44/Hippo/SP1 positive feedback loop potentiates stemness and metastasis in lung adenocarcinoma. Clinical and translational medicine 29 35485206
2018 NF-κB-driven improvement of EHD1 contributes to erlotinib resistance in EGFR-mutant lung cancers. Cell death & disease 29 29549343
2020 OsRE1 interacts with OsRIP1 to regulate rice heading date by finely modulating Ehd1 expression. Plant biotechnology journal 28 32757315
2009 Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly. Journal of cell science 27 19174465
2012 TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. PloS one 25 23119012
2021 A feedback circuit comprising EHD1 and 14-3-3ζ sustains β-catenin/c-Myc-mediated aerobic glycolysis and proliferation in non-small cell lung cancer. Cancer letters 24 34217785
2020 Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery. The Journal of biological chemistry 24 32041776
2019 MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium. Journal of cell science 24 31615969
2010 MICAL-L1: An unusual Rab effector that links EHD1 to tubular recycling endosomes. Communicative & integrative biology 23 20585517
2014 Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis. Traffic (Copenhagen, Denmark) 22 25287187
2016 EHD1 confers resistance to cisplatin in non-small cell lung cancer by regulating intracellular cisplatin concentrations. BMC cancer 21 27411790
2023 Exogenous abscisic acid represses rice flowering via SAPK8-ABF1-Ehd1/Ehd2 pathway. Journal of advanced research 20 37399924
2023 Improving yield-related traits by editing the promoter of the heading date gene Ehd1 in rice. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 20 37930441
2020 In-Frame and Frame-Shift Editing of the Ehd1 Gene to Develop Japonica Rice With Prolonged Basic Vegetative Growth Periods. Frontiers in plant science 19 32265960
2010 Pre-sorting endosomal transport of the GPI-anchored protein, CD59, is regulated by EHD1. Traffic (Copenhagen, Denmark) 18 20961375
2015 Molecular dynamics simulation of the interactions between EHD1 EH domain and multiple peptides. Journal of Zhejiang University. Science. B 17 26465136
2014 Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1. Journal of cell science 17 24481818
2023 EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole. EMBO reports 16 37074924
2015 The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function. Molecular biology of the cell 16 26202464
2014 Expression of TGFβ-1 and EHD1 correlated with survival of non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 16 24946721
2020 Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission. PloS one 15 32966336
2018 A Screen for Membrane Fission Catalysts Identifies the ATPase EHD1. Biochemistry 15 30403133
2013 EHD1 functions in endosomal recycling and confers salt tolerance. PloS one 15 23342166
2010 EHD1 is a synaptic protein that modulates exocytosis through binding to snapin. Molecular and cellular neurosciences 15 20696250
1999 Evaluation and molecular characterization of EHD1, a candidate gene for Bardet-Biedl syndrome 1 (BBS1). Gene 15 10564830
2016 CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface. Cellular signalling 14 27224507
2020 Engineering EHD1-Targeted Natural Borneol Nanoemulsion Potentiates Therapeutic Efficacy of Gefitinib against Nonsmall Lung Cancer. ACS applied materials & interfaces 13 32927941
2023 EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. Communications biology 12 37474760
2022 Coronin2A links actin-based endosomal processes to the EHD1 fission machinery. Molecular biology of the cell 12 35921168
2015 ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment. Molecular biology of the cell 12 26378252
2022 A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness. Journal of the American Society of Nephrology : JASN 11 35149593
2020 EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling. Molecular and cellular biology 11 31932478
2022 EHD1 promotes the cancer stem cell (CSC)-like traits of glioma cells via interacting with CD44 and suppressing CD44 degradation. Environmental toxicology 10 35616188
2015 The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. Developmental biology 10 26455409
2009 A model for the role of EHD1-containing membrane tubules in endocytic recycling. Communicative & integrative biology 9 19907710
2022 Entamoeba histolytica EHD1 Is Involved in Mitosome-Endosome Contact. mBio 8 35404118
2022 bZIP71 delays flowering by suppressing Ehd1 expression in rice. Journal of integrative plant biology 8 35546447
2015 Eps 15 Homology Domain (EHD)-1 Remodels Transverse Tubules in Skeletal Muscle. PloS one 8 26325203
2022 Interleukin-6 signaling requires EHD1-mediated alteration of membrane rafts. The FEBS journal 7 35429212
2008 EHDS are serine phosphoproteins: EHD1 phosphorylation is enhanced by serum stimulation. Cellular & molecular biology letters 7 18661112
2024 Enhancing Yield and Improving Grain Quality in Japonica Rice: Targeted EHD1 Editing via CRISPR-Cas9 in Low-Latitude Adaptation. Current issues in molecular biology 5 38666963
2016 The importance of EHD1 in neurite outgrowth contributing to the functional recovery after spinal cord injury. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 5 27211346
2025 m6A-modified EHD1 controls PD-L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma. Cancer communications (London, England) 4 40703029
2018 Triad1 regulates the expression and distribution of EHD1 contributing to the neurite outgrowth of neurons after spinal cord injury. Journal of cellular biochemistry 4 30320922
2017 Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorganic & medicinal chemistry 4 28951093
2024 EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signalling†. Biology of reproduction 3 38011671
2024 EHD1 promotes breast cancer metastasis through upregulating HIF2a expression via activating mTOR pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 3 39530565
2023 A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility. Frontiers in cell and developmental biology 3 37900275
2022 Transcription factor bZIP65 delays flowering via suppressing Ehd1 expression in rice. Molecular breeding : new strategies in plant improvement 3 37313010
2024 Systematic Analysis to Identify the MIR99AHG-has-miR-21-5p-EHD1 CeRNA Regulatory Network as Potential Biomarkers in Lung Cancer. Journal of Cancer 2 38495494
2020 Identification of phostensin in association with Eps 15 homology domain-containing protein 1 (EHD1) and EHD4. Biochemical and biophysical research communications 2 32800345
2017 Past1 Modulates Drosophila Eye Development. PloS one 2 28060904
2024 Increased EHD1 in trophoblasts causes RSM by activating TGFβ signaling†. Biology of reproduction 1 39012723

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