Affinage

LRP1

Prolow-density lipoprotein receptor-related protein 1 · UniProt Q07954

Length
4544 aa
Mass
504.6 kDa
Annotated
2026-04-28
100 papers in source corpus 40 papers cited in narrative 40 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LRP1 is a large multifunctional endocytic and signaling receptor that internalizes an exceptionally broad range of extracellular ligands — including lipoproteins, proteases/inhibitor complexes, heat shock proteins, tau, α-synuclein, and viral glycoproteins — via clathrin-coated pits and caveolae, delivering cargo to lysosomes for degradation or enabling transcytosis (PMID:19605848, PMID:34559985, PMID:32296178, PMID:22454511). Tyrosine phosphorylation of its intracellular NPxY motifs recruits adaptor proteins (Shc/SHC1, PSD95) to activate PI3K/Akt, ERK/JNK, PPARγ/LXR, and Rab8a/PI3Kγ signaling cascades that regulate cell survival, cholesterol efflux, inflammatory tone, and glucose metabolism (PMID:29144234, PMID:30208326, PMID:20644732, PMID:25855193). LRP1 also functions as a co-receptor that restrains PDGF receptor signaling in vascular smooth muscle cells — preventing aneurysm and atherosclerosis — and maintains blood–brain barrier tight junction integrity, Schwann cell myelination, astrocytic Aβ clearance, and neuronal regulation of NMDA receptor surface expression (PMID:12690199, PMID:34147102, PMID:23536074, PMID:28275161, PMID:23866919). In neurons, LRP1 mediates uptake and trans-neuronal spread of pathological tau and α-synuclein, positioning it as a central gateway for the propagation of neurodegenerative proteinopathies (PMID:32296178, PMID:36056345).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1997 Medium

    Identification of a circulating soluble form of LRP1 (sLRP) shed from liver established that the receptor's ectodomain can act as a decoy that antagonizes cell-bound LRP1 endocytic clearance of tPA, revealing an extracellular regulatory layer for LRP1 function.

    Evidence Affinity purification from human plasma, RAP binding, tPA degradation inhibition assay

    PMID:9295345

    Open questions at the time
    • Single lab; mechanism of ectodomain shedding not defined
    • Physiological significance of sLRP regulation of other ligands unknown
  2. 2000 High

    Demonstration that LRP1 (CD91) directly binds heat shock proteins gp96, hsp90, hsp70, and calreticulin on antigen-presenting cells — mediating uptake and MHC class I cross-presentation of chaperoned peptides — established LRP1 as a pattern-recognition receptor linking innate and adaptive immunity.

    Evidence Direct binding assays, competitive inhibition with α2-macroglobulin, proteasome/TAP inhibitor experiments in macrophages and dendritic cells; confirmed by siRNA knockdown and in vivo anti-CD91 blockade of tumor immunity

    PMID:11248808 PMID:11290339 PMID:15073331

    Open questions at the time
    • Structural basis for HSP recognition by LRP1 clusters not resolved
    • Relative contributions of LRP1 vs. other scavenger receptors to HSP-peptide cross-presentation in vivo
  3. 2002 Medium

    Finding that LRP1 is phosphorylated on serine and tyrosine residues and that tyrosine-phosphorylated LRP1 associates with the adaptor Shc provided the first evidence that LRP1 functions not merely as an endocytic receptor but as a signaling scaffold.

    Evidence Phosphorylation analysis and co-immunoprecipitation with Shc

    PMID:12069755

    Open questions at the time
    • Based on review-level summary of co-IP data; full mechanistic validation and identification of kinase not provided at that time
    • Downstream signaling consequences of Shc recruitment not delineated
  4. 2003 High

    Conditional knockout of LRP1 in vascular smooth muscle cells revealed that LRP1 forms a complex with PDGFRβ and restrains its signaling; loss of LRP1 causes PDGFR overactivation, SMC proliferation, aneurysm, and atherosclerosis — pharmacologically rescued by imatinib — establishing LRP1 as a critical co-receptor modulating growth factor receptor activity in the vessel wall.

    Evidence SMC-specific LRP1 conditional KO mouse, co-complex analysis, Gleevec pharmacological rescue

    PMID:12690199

    Open questions at the time
    • Molecular mechanism by which LRP1 suppresses PDGFR surface levels not fully defined
    • Whether LRP1 similarly regulates other RTKs in vascular cells was unknown
  5. 2005 High

    FRET-based demonstration that BACE1 interacts with LRP1 in lipid rafts and cleaves LRP1 to release both its ectodomain and intracellular domain identified LRP1 as a BACE1 substrate and linked LRP1 processing to the amyloidogenic pathway.

    Evidence FRET-FLIM, co-immunoprecipitation, lipid raft fractionation, fragment analysis in cells

    PMID:15749709

    Open questions at the time
    • Functional consequence of LRP1 intracellular domain release (nuclear signaling?) not established
    • Whether BACE1 cleavage of LRP1 is regulated in disease states was not addressed
  6. 2007 High

    Studies on transglutaminase and protease nexin-1 broadened the ligand repertoire by showing LRP1-dependent constitutive internalization and lysosomal degradation of cell-surface transglutaminase and PN-1-LRP interaction antagonizing SHH-driven proliferation in cerebellar granule neuron precursors.

    Evidence LRP1-deficient cells with endocytosis/lysosomal assays (transglutaminase); PN-1 KO mouse with SHH pathway analysis (PN-1/LRP)

    PMID:17409116 PMID:17711877

    Open questions at the time
    • PN-1 study did not fully distinguish LRP1-specific from other LRP family member contributions
    • Structural basis for ligand discrimination among diverse substrates unclear
  7. 2008 High

    LRP1 was shown to regulate PrPC endocytosis in neurons (nanomolar-affinity binding) and to modulate APP trafficking through early secretory compartments, and to activate PI3K/Akt survival signaling downstream of TSP1/calreticulin binding to confer anoikis resistance — collectively establishing LRP1 as both a neuronal cargo receptor and a signaling platform for cell survival.

    Evidence siRNA/co-IP/purified protein binding (PrPC); ER-retention mutant co-trafficking (APP); LRP1-KO fibroblasts with PI3K/Akt and anoikis assays (TSP1/calreticulin)

    PMID:18285446 PMID:18559293 PMID:18653767

    Open questions at the time
    • APP trafficking modulation based on single ER-retention construct approach
    • Whether PrPC internalization via LRP1 contributes to prion disease propagation not tested
  8. 2009 High

    LRP1 loss in macrophages was linked to PDGFR-MAPK-cPLA2-mediated suppression of LXR/ABCA1, reducing cholesterol efflux; separately, LRP1 was shown to mediate platelet factor 4 inhibition of megakaryopoiesis, expanding LRP1's role to hematopoietic regulation and lipid homeostasis integration.

    Evidence LRP1-deficient macrophage signaling pathway dissection; shRNA/RAP/antibody blockade in megakaryocyte cultures and PF4-overexpressing mice

    PMID:19605848 PMID:19718435

    Open questions at the time
    • Direct structural basis for PF4–LRP1 interaction not mapped
    • In vivo relevance of LRP1 to macrophage reverse cholesterol transport in atherosclerotic lesions needed more study
  9. 2010 High

    Three studies established LRP1 as a multifunctional signaling hub: (1) LRP1 docks MAPK complexes to control ERK/JNK balance and cell adhesion in cancer; (2) LRP1 is essential for macrophage Akt survival signaling and efferocytosis; (3) LRP1 mediates TSP2-driven Notch3 trans-endocytosis — demonstrating that LRP1's signaling scaffolding is cell-type-dependent.

    Evidence shRNA + co-IP + kinase mutants in cancer cells; LRP1-KO macrophages with efferocytosis and phospho-Akt assays; LRP1-deficient fibroblasts with Notch3 endocytosis and RAP inhibition

    PMID:20150557 PMID:20472562 PMID:20644732

    Open questions at the time
    • How LRP1 selects among distinct signaling outputs in different cell types not mechanistically explained
    • Notch3 trans-endocytosis mechanism requires structural characterization
  10. 2013 High

    Schwann cell-specific and NPxY2 knock-in mouse models showed LRP1 is required for peripheral nerve myelination and for phosphorylation-dependent regulation of NR2B NMDA receptor surface expression via PSD95, revealing essential nervous system functions beyond ligand clearance.

    Evidence Schwann cell-specific LRP1 KO with nerve histology and pain behavior; NPxY2 knock-in mouse with surface biotinylation, co-IP (LRP1-NR2B-PSD95), endocytosis assay

    PMID:23536074 PMID:23866919

    Open questions at the time
    • Kinase responsible for NPxY2 phosphorylation in neurons not identified
    • Whether LRP1-NR2B regulation affects synaptic plasticity/LTP not established
  11. 2014 High

    Discovery that the microtubule motor KIF13B recruits LRP1 to caveolae via an hDLG1-utrophin-caveolin linkage for caveolae-dependent endocytosis revealed a motor-driven mechanism of LRP1 trafficking distinct from clathrin-coated pit internalization.

    Evidence KIF13B KO mouse with elevated serum cholesterol/factor VIII, KO MEFs with decreased LDL uptake, co-IP defining molecular chain

    PMID:24469637

    Open questions at the time
    • Relative quantitative contribution of caveolae vs. clathrin pathways for LRP1 endocytosis in different tissues unknown
    • Whether KIF13B regulates LRP1 signaling outputs not tested
  12. 2015 High

    LRP1 was found to directly interact with PARP-1 in retinal endothelial cells, suppressing PARP-1 activity and restraining cell cycle progression; endothelial LRP1 KO mice showed increased retinal neovascularization under hypoxia, establishing LRP1 as an anti-angiogenic checkpoint.

    Evidence Co-immunoprecipitation (LRP1-PARP-1), siRNA knockdown, endothelial conditional KO mouse, oxygen-induced retinopathy model

    PMID:26634655

    Open questions at the time
    • Mechanism of LRP1-PARP-1 physical interaction (direct or indirect) not structurally resolved
    • Generalizability to non-retinal endothelial beds not tested
  13. 2017 High

    Multiple conditional KO studies converged to define cell-type-specific LRP1 functions: astrocytic LRP1 drives Aβ clearance and degrading enzyme expression; neuronal LRP1 interacts with insulin receptor β to regulate glucose uptake; macrophage LRP1 NPxY phosphorylation activates a SHC1/PI3K/Akt/PPARγ/LXR/ABCA1 axis for cholesterol homeostasis; and LRP1 endocytoses β1-integrin to regulate its recycling.

    Evidence Astrocyte-specific Lrp1 KO in APP/PS1 mice; neuronal LRP1 KO with in vivo microdialysis; macrophage NPxY knock-in mouse; siRNA/RAP/domain-binding assays for β1-integrin in thyroid cancer cells

    PMID:25855193 PMID:28275161 PMID:29108253 PMID:29144234

    Open questions at the time
    • Whether astrocytic LRP1-mediated Aβ clearance is relevant for non-APP/PS1 Alzheimer's models
    • Insulin receptor–LRP1 interaction domains not mapped
  14. 2018 High

    TLR-induced Y4507 phosphorylation of LRP1 was shown to recruit Rab8a/PI3Kγ to macropinosomal membranes to suppress inflammation, and p53 was identified as a transcriptional activator of LRP1 with miR-103/107-mediated negative feedback at lethal stress doses — connecting LRP1 to innate immune resolution and the DNA damage response.

    Evidence CRISPR KO with Rab8a activation and cytokine profiling; p53 target gene identification with miRNA translational repression assay

    PMID:30089260 PMID:30208326

    Open questions at the time
    • Whether Y4507 phosphorylation-Rab8a axis operates in tissue macrophages in vivo not shown
    • Functional consequence of p53-driven LRP1 expression for cell fate not fully dissected
  15. 2019 High

    Neuronal LRP1 was shown to be required for apoE4-mediated exacerbation of Aβ pathology; its deletion reversed increased Aβ deposition caused by apoE4, establishing that apoE4's pro-amyloidogenic effect is LRP1-dependent.

    Evidence Neuronal LRP1 conditional KO crossed with APP/PS1 and APOE-targeted replacement mice, quantitative Aβ and amyloid measurements

    PMID:30741718

    Open questions at the time
    • Whether the effect is mediated by LRP1-dependent Aβ internalization vs. apoE clearance not resolved
    • Applicability to human AD beyond transgenic mouse models
  16. 2020 High

    LRP1 was identified as the principal neuronal receptor for tau uptake and trans-neuronal spread; tau binds LRP1 through lysine residues in its microtubule-binding repeat region; phosphorylated tau binds LRP1 with reduced affinity, and apoE4 more potently inhibits LRP1-mediated tau uptake than apoE3.

    Evidence siRNA in H4 cells and iPSC-derived neurons, in vivo tau spread model with LRP1 downregulation, SPR affinity measurement, tau seeding assay

    PMID:32296178 PMID:33930462

    Open questions at the time
    • Whether LRP1-mediated tau uptake is protective (degradation) or pathogenic (seeding) remains context-dependent and unresolved
    • Structural basis of tau–LRP1 interaction at atomic resolution unknown
  17. 2021 High

    Genome-wide CRISPR screens and direct binding assays identified LRP1 as a host entry factor for both RVFV and OROV bunyaviruses; RAP competition and in vivo protection studies validated LRP1 as a therapeutic target against these viral infections. Separately, brain endothelial LRP1 ablation was shown to compromise BBB integrity through tight junction degradation.

    Evidence CRISPR screen + Gn–Lrp1 binding + RAP mutagenesis + mouse survival (RVFV); Lrp1-KO cells + VSV-OROV binding + in vivo RAP treatment (OROV); CNS endothelial conditional KO with BBB permeability assay

    PMID:34147102 PMID:34559985 PMID:35939689

    Open questions at the time
    • Which specific LRP1 clusters mediate bunyavirus Gn recognition not fully mapped
    • Mechanism by which endothelial LRP1 maintains tight junctions (direct interaction vs. signaling) not clarified
  18. 2022 High

    LRP1 was established as the primary neuronal receptor for α-synuclein uptake and spread, with lysine residues on α-synuclein's N-terminus mediating LRP1-dependent internalization, paralleling the mechanism for tau; neuronal Lrp1 conditional KO significantly reduced α-synuclein spread in vivo.

    Evidence CRISPR/Cas9 LRP1-KO iPSC neurons, lysine blocking, neuronal conditional KO mouse with AAV-based α-synuclein spread assay

    PMID:36056345

    Open questions at the time
    • Whether LRP1-mediated α-synuclein uptake leads to degradation or seeded aggregation in physiological contexts not resolved
    • Shared vs. distinct LRP1-binding determinants for tau and α-synuclein not structurally compared

Open questions

Synthesis pass · forward-looking unresolved questions
  • A unified structural model of how LRP1's four ligand-binding clusters discriminate among >50 ligands, and how intracellular domain phosphorylation states switch between endocytic vs. signaling outputs in a cell-type-specific manner, remains unresolved.
  • No high-resolution full-length LRP1 structure available
  • Cell-type determinants of LRP1 signaling specificity (e.g., why PI3K/Akt in macrophages vs. NR2B regulation in neurons) not mechanistically explained
  • Whether LRP1-mediated uptake of pathological tau and α-synuclein is net protective or pathogenic in human neurodegeneration unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0038024 cargo receptor activity 8 GO:0060090 molecular adaptor activity 5 GO:0098772 molecular function regulator activity 3
Localization
GO:0005886 plasma membrane 7 GO:0005768 endosome 2 GO:0005783 endoplasmic reticulum 2 GO:0031410 cytoplasmic vesicle 2 GO:0005576 extracellular region 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-168256 Immune System 5 R-HSA-1643685 Disease 4 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9609507 Protein localization 3 R-HSA-1430728 Metabolism 2
Partners
BACE1CALRINSRKIF13BPARP1PDGFRBPSD95SHC1
Complex memberships
LRP1-PDGFRβ complexcalreticulin-LRP1 co-receptor complex

Evidence

Reading pass · 40 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 LRP1 (CD91) is a direct cell-surface receptor for the heat shock protein gp96 on antigen-presenting cells; CD91 binds gp96 directly rather than through another ligand, and the known CD91 ligand alpha-2-macroglobulin inhibits re-presentation of gp96-chaperoned antigenic peptides by macrophages. Direct binding assay, competitive inhibition with alpha-2-macroglobulin, antibody blocking of CD91 Nature immunology High 11248808
2001 LRP1 (CD91) serves as a common receptor for multiple heat shock proteins — gp96, hsp90, hsp70, and calreticulin — mediating their uptake by macrophages and dendritic cells and enabling re-presentation of chaperoned peptides via MHC class I; post-uptake processing requires proteasomes and TAP transporters. Uptake and re-presentation assays in macrophages and dendritic cells, proteasome/TAP inhibitor experiments Immunity High 11290339
2003 LRP1 forms a complex with the PDGF receptor (PDGFR) in vascular smooth muscle cells; inactivation of LRP1 causes PDGFR overexpression and abnormal activation of PDGFR signaling, leading to SMC proliferation, aneurysm formation, and susceptibility to atherosclerosis. Treatment with the PDGF signaling inhibitor Gleevec reduced these abnormalities. Tissue-specific LRP1 knockout mouse model, pharmacological inhibition with Gleevec, co-complex analysis Science High 12690199
2004 CD91 (LRP1) is essential for re-presentation of gp96-chaperoned peptides by antigen-presenting cells; siRNA knockdown of CD91 causes corresponding decline in re-presenting ability, and protective tumor immunity elicited by gp96-peptide complexes is abrogated by anti-CD91 antisera in vivo. siRNA knockdown, in vitro and in vivo re-presentation assays, in vivo tumor immunity assay with anti-CD91 antisera Proceedings of the National Academy of Sciences of the United States of America High 15073331
2003 Surfactant proteins SP-A and SP-D bind calreticulin/LRP1 (CD91) through their collagenous tail domains to stimulate proinflammatory mediator production and phagocytosis, while their globular heads bind SIRPalpha to suppress inflammation — establishing LRP1 as part of a dual-function surveillance receptor complex. Binding orientation studies, co-receptor complex identification, inflammatory mediator assays Cell High 14531999
2005 LRP1 interacts with BACE1 (beta-secretase) on the cell surface in association with lipid rafts; BACE1-LRP1 interaction leads to increased LRP1 C-terminal fragment generation, release of secreted LRP1, and subsequent release of the LRP1 intracellular domain, identifying LRP1 as a novel BACE1 substrate. FRET-based FLIM assay, co-immunoprecipitation, cell surface interaction assay with lipid raft fractionation The Journal of biological chemistry High 15749709
2008 LRP1 associates with prion protein (PrPC) during endocytosis in neurons and is functionally required for PrPC endocytosis; LRP1 siRNA knockdown leads to accumulation of PrPC in biosynthetic compartments and lowering of surface PrPC. The N-terminal domain of PrPC binds purified LRP1 with nanomolar affinity, and LRP1 co-immunoprecipitates with PrPC from the endoplasmic reticulum. siRNA knockdown, co-immunoprecipitation from ER, purified protein binding assay (nanomolar affinity measurement), live imaging Journal of cell science High 18285446
2008 LRP1 modulates APP trafficking along early secretory compartments; LRP1 with an ER-retention motif retards APP trafficking in the secretory pathway, demonstrating that the C-terminal domain of LRP1 interacts with APP early in the secretory pathway and influences APP metabolism. LRP1 ER-retention mutant expression, co-trafficking assay, subcellular fractionation Neurobiology of disease Medium 18559293
2008 TSP1 signals through the calreticulin-LRP1 co-complex to promote fibroblast survival under anchorage-independent conditions (anoikis resistance) by activating PI3K/Akt and decreasing caspase 3/PARP1 signaling; fibroblasts lacking LRP1 or expressing calreticulin lacking the TSP1 binding site do not respond to TSP1 with anchorage-independent survival. LRP1-deficient fibroblasts, calreticulin mutant cells, PI3K inhibition, Akt activation assay, anoikis assay FASEB journal High 18653767
2010 LRP1 regulates ERK and JNK signaling in cancer cells: LRP1 serves as an intracellular docking site for MAPK-containing complexes (co-immunoprecipitation), maintains cells in an adhesive/invasive state by activating ERK and inhibiting JNK, controls cytoskeletal architecture, and is tethered to the actin network and focal adhesion sites. shRNA-mediated silencing, co-immunoprecipitation, pharmacological agents, constitutively active and dominant-negative kinases PloS one High 20644732
2010 LRP1 deficiency in macrophages impairs Akt survival signaling (phospho-Akt barely detectable in LRP1-KO cells), decreases phospho-Bad, increases cleaved caspase-3, and reduces efferocytosis by 60%, establishing LRP1 as a regulator of macrophage survival and efferocytosis through the Akt pathway. LRP1-KO macrophages, apoptosis assays (TUNEL), phosphoprotein analysis, efferocytosis assay, in vivo lesion analysis Arteriosclerosis, thrombosis, and vascular biology High 20150557
2010 Thrombospondin-2 (TSP2) potentiates Notch3 signaling via LRP1: TSP2 stimulates Notch3 endocytosis into wild-type but not LRP1-deficient fibroblasts; recombinant Notch3 and Jagged1 interact with the LRP1 85-kDa B-chain; RAP blocks TSP2 potentiation of Notch; LRP1 in the signal-sending cell is required for TSP2-driven trans-endocytosis of the Notch ectodomain. LRP1-deficient fibroblasts, co-immunoprecipitation with LRP1 subunit, RAP inhibitor, Notch endocytosis assay The Journal of biological chemistry High 20472562
2013 LRP1 deletion in Schwann cells causes abnormal axon myelination and defective ensheathment of axons in Remak bundles, leading to mechanical allodynia even without nerve injury; after crush injury, LRP1-deficient Schwann cells show accelerated degeneration, failure to remyelinate, and increased central sensitization (p38MAPK activation in spinal cord). Schwann cell-specific LRP1 conditional KO mouse, nerve injury models, histology, behavioral pain assays The Journal of neuroscience High 23536074
2013 LRP1 regulates NR2B NMDA receptor subunit surface expression: knock-in mutation of the NPxY2 motif of LRP1 increases surface expression of LRP1 and NR2B due to reduced endocytosis; LRP1-NR2B interaction is phosphorylation-dependent and may be linked through PSD95 (co-immunoprecipitation); this regulation mechanism is impaired in LRP1ΔNPxY2 neurons. NPxY2 knock-in mouse model, co-immunoprecipitation, surface biotinylation, endocytosis assay, behavioral tests Molecular neurodegeneration High 23866919
2014 KIF13B, a microtubule-based motor protein, enhances caveolin-dependent endocytosis of LRP1 by recruiting LRP1 to caveolae via LRP1-hDLG1-KIF13B-utrophin-caveolae linkage; KIF13B KO mice show elevated serum cholesterol and factor VIII, and KO MEFs show decreased LDL uptake. KIF13B knockout mouse, KO MEF cells, co-immunoprecipitation, caveolin localization assays, serum lipid measurements The Journal of cell biology High 24469637
2017 Astrocytic LRP1 plays a critical role in brain Aβ clearance: LRP1 knockdown in primary astrocytes reduces Aβ uptake and degradation and downregulates Aβ-degrading enzymes MMP2, MMP9, and insulin-degrading enzyme; conditional KO of Lrp1 in astrocytes of APP/PS1 mice impairs brain Aβ clearance and exacerbates amyloid plaque deposition without affecting Aβ production. siRNA knockdown in primary astrocytes, astrocyte-specific conditional Lrp1 KO in APP/PS1 mice, Aβ uptake/degradation assays, enzyme expression analysis The Journal of neuroscience High 28275161
2017 LRP1 interacts with insulin receptor β in the brain and regulates insulin signaling and glucose uptake; LRP1 deficiency in neurons leads to impaired insulin signaling and reduced GLUT3/GLUT4 glucose transporter levels; in vivo microdialysis in neuronal LRP1 conditional KO mice confirms glucose intolerance in the brain; hyperglycemia suppresses LRP1 expression creating a feed-forward cycle. Co-immunoprecipitation (LRP1-insulin receptor β), neuronal LRP1 conditional KO mouse, in vivo microdialysis, glucose transporter expression analysis The Journal of neuroscience High 25855193
2018 TLR activation in macrophages induces phosphorylation of LRP1 at Y4507, which then activates and recruits Rab8a with PI3Kγ (p110γ/p101) as effector complex on macropinosomal membranes to suppress inflammatory responses; CRISPR KO of LRP1 abolishes TLR-induced Rab8 activation and produces a pro-inflammatory bias in cytokine outputs. CRISPR KO, phospho-specific antibody, Rab8a activation assay, co-localization by microscopy, cytokine profiling, PI3Kγ interaction assay Cell reports High 30208326
2017 LRP1 in macrophages links tyrosine phosphorylation of its intracellular NPxY motif to a signaling cascade along an LRP1/SHC1/PI3K/AKT/PPARγ/LXR axis to regulate cholesterol homeostasis through ABCA1 expression and integrates apoptotic cell removal with inflammatory responses; established using a knockin mouse model. LRP1 NPxY knockin mouse model, phosphorylation analysis, signaling pathway dissection eLife High 29144234
2020 LRP1 controls endocytosis of tau and its subsequent spread between neurons; interaction between tau and LRP1 is mediated by lysine residues in the microtubule-binding repeat region of tau; LRP1 knockdown significantly reduces tau uptake in neuroglioma cells and iPSC-derived neurons; downregulation of LRP1 in vivo reduces tau propagation between neurons in a mouse model. siRNA knockdown in H4 cells, iPSC-derived neuron knockdown, in vivo mouse model of tau spread with LRP1 downregulation Nature High 32296178
2021 LRP1 rapidly internalizes tau and delivers it to lysosomes for degradation; phosphorylated tau binds weakly to LRP1 and is less efficiently internalized; apoE4 inhibits LRP1-mediated tau uptake more potently than apoE3 (likely due to higher affinity for LRP1); LRP1-expressing cells promote cytosolic tau seeding by pathological tau in an apoE-enhanced manner. Surface plasmon resonance (affinity measurement), 125I-labeled tau internalization assay, lysosomal degradation assay, tau seeding assay in LRP1-deficient vs expressing cells The Journal of biological chemistry High 33930462
2021 Lrp1 is a host entry factor for Rift Valley fever virus (RVFV): RVFV glycoprotein Gn directly binds to specific Lrp1 clusters in a glycosylation-independent manner; exogenous RAP domain 3 and anti-Lrp1 antibodies neutralize RVFV infection; RAP domain 3 treatment protects mice from RVFV disease and death; a weak-binding RAP mutant fails to protect. Genome-wide CRISPR screen, direct binding assay (Gn-Lrp1), in vivo mouse protection study with RAP domain 3, mutagenesis of RAP Cell High 34559985
2022 LRP1 is a neuronal receptor for α-synuclein uptake and spread; LRP1-KO iPSC-derived neurons show significantly reduced uptake of monomeric and oligomeric α-Syn; lysine residues on α-Syn (particularly N-terminus) mediate LRP1-dependent internalization; neuronal Lrp1 conditional KO mice show significantly reduced α-Syn spread in vivo. CRISPR/Cas9 LRP1-KO iPSC lines, flow cytometry uptake assay, lysine blocking with sulfo-NHS acetate, neuronal Lrp1 conditional KO mouse, AAV-based spread assay Molecular neurodegeneration High 36056345
2007 Cell-surface transglutaminase is constitutively internalized and degraded in lysosomes in an LRP1-dependent manner; transglutaminase interacts with LRP1 in vitro and on the cell surface; LRP1 deficiency or blockade of endo-lysosomal function upregulates transglutaminase surface expression, leading to increased cell adhesion and matrix crosslinking. Co-immunoprecipitation (in vitro and cell surface), LRP1-deficient cells, dynamin/cholesterol depletion, lysosomal inhibition assay Journal of cell science High 17711877
2009 LRP1 mediates the negative regulatory effect of platelet factor 4 (PF4) on megakaryopoiesis: LRP1 is expressed on large polyploid megakaryocytes; blocking LRP1 with RAP or anti-LRP1 antibodies reverses PF4 inhibition of megakaryocyte colony growth; shRNA knockdown of LRP1 restores megakaryocyte colony formation in PF4-overexpressing mice; RAP infusion in vivo increases platelet counts. shRNA knockdown, RAP antagonist, anti-LRP1 antibodies, in vivo RAP infusion in PF4-overexpressing mice, colony formation assay Blood High 19605848
2012 LRP1 mediates transcytosis of CCN2 (CTGF) in chondrocytes via clathrin-dependent endocytosis; CCN2 internalized via LRP1 colocalizes with early/recycling endosomes; LRP1 knockdown decreases CCN2 binding/incorporation; LRP1 antagonist decreases transcytosis of CCN2 across chondrocyte monolayers; hypoxia increases LRP1 levels and CCN2 transcytosis. siRNA knockdown, LRP1 antagonist (RAP), transwell transcytosis assay, endosome co-localization, clathrin inhibition Journal of cell science High 22454511
2002 LRP1 is phosphorylated on serine and tyrosine residues; tyrosine-phosphorylated LRP1 specifically associates with the cellular docking protein Shc, suggesting LRP1 ligand internalization is regulated by phosphorylation and that LRP1 participates in signal transduction. Phosphorylation analysis, co-immunoprecipitation with Shc Trends in cardiovascular medicine Medium 12069755
2009 LRP1 absence results in increased PDGFRβ signaling, sequential activation of MAPK, increased phosphorylation of cytosolic phospholipase A2 (cPLA2), overproduction of arachidonic acid, and suppression of LXR/RXR-mediated ABCA1 expression, thereby reducing reverse cholesterol transport; LRP1 thus functions as an integrator of lipid homeostasis and proliferation signaling. LRP1-deficient cells, PDGFRβ signaling assays, cPLA2 phosphorylation, arachidonic acid measurement, LXR/RXR promoter assay, ABCA1 expression analysis PloS one High 19718435
2019 Neuronal LRP1 is required for APOE4-mediated exacerbation of Aβ pathology; neuronal LRP1 deficiency reverses the increased Aβ deposition caused by apoE4 in APP/PS1 mice and increases detergent-soluble apoE4 levels, suggesting apoE4 exacerbates Aβ pathology through a mechanism depending on neuronal LRP1. Neuronal LRP1 conditional KO crossed with APP/PS1 and APOE-targeted replacement mice, Aβ measurement (soluble and insoluble fractions), amyloid deposition quantification The Journal of clinical investigation High 30741718
2020 TIMP-3 binds LRP1 with highest affinity (KD = 1.68 nM) among tested metalloproteinase-related proteins; TIMP-3 facilitates clearance of target metalloproteinases (MMP-1, MMP-13, MMP-14) by bridging their binding to LRP1 — the MMP-1/TIMP-3 complex has sevenfold higher affinity for LRP1 than free MMP-1; MMP-1 is identified as a new LRP1 ligand (KD = 34.6 nM). Surface plasmon resonance (quantitative affinity measurement for multiple protein pairs) Scientific reports High 32694578
2021 OROV glycoproteins bind the Lrp1 ectodomain in vitro (chimeric VSV-OROV); cells lacking Lrp1 are less permissive to OROV infection; RAP treatment and recombinant Lrp1 ectodomain truncations significantly reduce OROV infection; RAP treatment at infection reduces tissue viral load and promotes survival from lethal OROV infection in mice. Lrp1-KO cells across multiple species, in vitro binding assay with VSV-OROV, RAP competition, in vivo mouse protection study Proceedings of the National Academy of Sciences of the United States of America High 35939689
2015 LRP1 directly interacts with PARP-1 in human retinal microvascular endothelial cells; this interaction decreases under hypoxia; LRP1 knockdown results in increased PARP-1 activity and subsequent phosphorylation of retinoblastoma protein and CDK2, promoting cell cycle progression; endothelial LRP1 KO mice show increased retinal neovascularization. Co-immunoprecipitation (LRP1-PARP-1), LRP1 siRNA knockdown, endothelial LRP1 conditional KO mouse, retinal angiogenesis assay (oxygen-induced retinopathy model) Arteriosclerosis, thrombosis, and vascular biology High 26634655
2017 LRP1 acts as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells; LRP1 binds both inactive and active β1-integrin conformations through extracellular ligand-binding domains II or IV; LRP1 knockdown/blockade increases β1-integrin surface levels and decreases β1-integrin-containing endosomes and Rab11-positive recycling vesicles. LRP1 siRNA/RAP/blocking antibody, direct binding assay with recombinant LRP1 domains, endosome localization assay, Rab11 co-localization Oncotarget High 29108253
2018 LRP1 is a p53 target gene; LRP1 transcript is upregulated by both sub-lethal and lethal doses of p53-activating stress, but LRP1 protein is only upregulated by sub-lethal stress; lethal doses of stress induce p53-regulated miRNAs miR-103 and miR-107 that suppress LRP1 translation, establishing a negative feedback loop controlling cell survival vs. cell death. p53 target gene identification, miRNA expression analysis, translational repression assay, LRP1 protein vs. mRNA quantification at different stress doses Cell reports High 30089260
2021 Glucocorticoid (GC) induces glucocorticoid receptor (GR)-dependent direct trans-repression of LRP1 expression in macrophages; reduced LRP1 in turn elevates SIRPα by downregulating miRNA-4695-3p, creating an imbalance in the LRP1/SIRPα axis that impairs macrophage phagocytosis of tumor cells. Glucocorticoid treatment, GR-dependent transcriptional analysis, miRNA-4695-3p measurement, phagocytosis assay, LRP1/SIRPα expression analysis Acta pharmaceutica Sinica. B Medium 35127380
2022 Exosomal HSP90 binds to LRP1 on recipient cell membranes to activate downstream AKT signaling; LRP1 knockdown in fibroblasts impairs AKT activation and abrogates the beneficial effects of adipose stem cell-derived exosomes on wound healing and oxidative stress resistance. Anti-HSP90 antibody neutralization, LRP1 siRNA knockdown, AKT signaling assay, wound healing model Cells Medium 36291096
1997 A soluble form of LRP1 (sLRP) circulates in human plasma; it is shed from the liver, binds the receptor-associated protein (RAP) and tPA-inhibitor complexes, and addition of sLRP to cultured cells significantly inhibits cellular degradation of tPA — establishing that shed LRP1 can antagonize cell-bound LRP1 endocytic function. Affinity purification from plasma, SDS-PAGE, anti-LRP1 antibody immunoblot, RAP binding, tPA degradation inhibition assay The Journal of biological chemistry Medium 9295345
2023 FUT2-induced α-1,2 fucosylation of LRP1 inhibits colorectal cancer EMT and metastasis; FUT2 overexpression suppresses invasion in vitro and tumor dissemination in vivo; quantitative glycoproteomics and co-immunoprecipitation identified LRP1 as the mediator of FUT2's invasion-inhibiting effects. Quantitative proteomics of glycosylated proteins, UEA enrichment, co-immunoprecipitation, invasion assay, nude mouse peritoneal dissemination model, FUT2 KO mice Cell communication and signaling Medium 36973740
2007 Protease nexin 1 (PN-1) interacts with LRP1 (LRPs) to antagonize SHH-induced cerebellar granule neuron precursor (CGNP) proliferation; PN-1 binding to LRP interferes with SHH-induced cyclin D1 expression and inhibits GLI1 transcriptional activity; PN-1-deficient mice show enhanced basal CGNP proliferation through SHH pathway overactivation. PN-1-deficient mouse, SHH pathway analysis, cyclin D1 expression, GLI1 reporter assay, LRP binding assay Development Medium 17409116
2021 Brain endothelial LRP1 ablation (using Slco1c1-CreERT2) causes protease-mediated tight junction degradation, P-glycoprotein reduction, and loss of blood-brain barrier integrity, establishing LRP1 as a regulator of BBB tight junction integrity. CNS endothelial-specific conditional LRP1 KO (Slco1c1-CreERT2), tight junction protein analysis, P-gp measurement, BBB permeability assay Fluids and barriers of the CNS High 34147102

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 840 11290339
2003 By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 539 14531999
2000 CD91: a receptor for heat shock protein gp96. Nature immunology 516 11248808
2003 LRP: role in vascular wall integrity and protection from atherosclerosis. Science (New York, N.Y.) 483 12690199
2006 RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease. Acta neuropathologica 427 16865397
2020 LRP1 is a master regulator of tau uptake and spread. Nature 424 32296178
2017 Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. The Journal of neuroscience : the official journal of the Society for Neuroscience 221 28275161
2005 The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. The Journal of biological chemistry 210 15749709
2007 The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Annals of medicine 197 17457719
2011 CD91-dependent programming of T-helper cell responses following heat shock protein immunization. Nature communications 168 22045000
2004 Essential role of CD91 in re-presentation of gp96-chaperoned peptides. Proceedings of the National Academy of Sciences of the United States of America 168 15073331
2005 Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. Journal of thrombosis and haemostasis : JTH 160 16102056
2010 Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arteriosclerosis, thrombosis, and vascular biology 135 20150557
2019 APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. The Journal of clinical investigation 129 30741718
2006 LRP in amyloid-beta production and metabolism. Annals of the New York Academy of Sciences 123 17185504
1995 A consensus sequence for binding of Lrp to DNA. Journal of bacteriology 118 7665463
2015 Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 117 25855193
1997 Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma. The Journal of biological chemistry 115 9295345
2006 Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus. Arthritis and rheumatism 112 16645988
1995 LRP1, a gene expressed in lateral and adventitious root primordia of arabidopsis. The Plant cell 104 7647564
2021 Lrp1 is a host entry factor for Rift Valley fever virus. Cell 99 34559985
2021 Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. The Journal of biological chemistry 97 33930462
2010 Signaling through LRP1: Protection from atherosclerosis and beyond. Biochemical pharmacology 96 20920479
2008 LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. Journal of cell science 92 18285446
2022 LRP1 is a neuronal receptor for α-synuclein uptake and spread. Molecular neurodegeneration 88 36056345
2006 CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes. Immunobiology 81 16920480
2010 LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways. PloS one 80 20644732
2019 Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice. Molecular and cellular neurosciences 77 31276749
2017 LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. eLife 76 29144234
2016 Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections. American journal of human genetics 73 27569546
2008 Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 72 18653767
1997 Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR? Seminars in cancer biology 72 9441949
2018 TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses. Cell reports 71 30208326
2006 The role of megalin (LRP-2/Gp330) during development. Developmental biology 71 16828734
2002 Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. Journal of immunology (Baltimore, Md. : 1950) 71 11970968
2012 Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91. PloS one 70 22412839
2016 The role of the low-density lipoprotein receptor-related protein 1 (LRP-1) in regulating blood-brain barrier integrity. Reviews in the neurosciences 69 27206317
1994 Regulation of the Escherichia coli lrp gene. Journal of bacteriology 67 8144448
2013 Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 66 23536074
2022 Exosomes from Adipose Stem Cells Promote Diabetic Wound Healing through the eHSP90/LRP1/AKT Axis. Cells 63 36291096
2008 LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities. Molecular and cellular biology 63 18316405
2004 Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 63 15647823
2008 LRP1 modulates APP trafficking along early compartments of the secretory pathway. Neurobiology of disease 59 18559293
2003 Expression of MRP1, LRP and Pgp in breast carcinoma patients treated with preoperative chemotherapy. Breast cancer research and treatment 59 14572157
2013 Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages. Cell and tissue research 58 23963646
2014 KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. The Journal of cell biology 57 24469637
2001 Adjuvanticity of alpha 2-macroglobulin, an independent ligand for the heat shock protein receptor CD91. Journal of immunology (Baltimore, Md. : 1950) 57 11290775
2019 Auxin signaling modulates LATERAL ROOT PRIMORDIUM1 (LRP1) expression during lateral root development in Arabidopsis. The Plant journal : for cell and molecular biology 55 31483536
2008 Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR. PloS one 54 19008962
1989 Structure of the low-density lipoprotein receptor-related protein (LRP) promoter. Biochimica et biophysica acta 54 2597675
2014 Lactoferrin stimulates osteoblast differentiation through PKA and p38 pathways independent of lactoferrin's receptor LRP1. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 53 24877241
2002 Phosphorylation of LRP1: regulation of transport and signal transduction. Trends in cardiovascular medicine 52 12069755
2007 Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1. Journal of cell science 51 17711877
2022 Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1. Proceedings of the National Academy of Sciences of the United States of America 49 35939689
2015 LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. PloS one 48 26061292
2012 Role of LRP1 in transport of CCN2 protein in chondrocytes. Journal of cell science 48 22454511
2009 Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood 48 19605848
2015 The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment. Frontiers in pharmacology 45 26617523
2013 LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Molecular neurodegeneration 45 23866919
2014 LRP-1: functions, signaling and implications in kidney and other diseases. International journal of molecular sciences 44 25514242
2010 High efficiency CD91- and LOX-1-mediated re-presentation of gp96-chaperoned peptides by MHC II molecules. Cancer immunity 44 20672796
2004 LRP and PDGF signaling: a pathway to atherosclerosis. Trends in cardiovascular medicine 44 15030790
2010 Direct interaction between CD91 and C1q. The FEBS journal 43 20716178
2013 Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease. Expert opinion on therapeutic targets 42 23573918
2017 LRP1: A chameleon receptor of lung inflammation and repair. Matrix biology : journal of the International Society for Matrix Biology 40 29262309
2015 LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation. Arteriosclerosis, thrombosis, and vascular biology 40 26634655
2004 A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens. Journal of immunology (Baltimore, Md. : 1950) 40 14688311
2018 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell reports 38 30089260
2014 Regulation of LRP-1 expression: make the point. Pathologie-biologie 38 24661974
2009 LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PloS one 37 19718435
2023 FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation. Cell communication and signaling : CCS 36 36973740
2021 The molecular mechanism of LRP1 in physiological vascular homeostasis and signal transduction pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 36 34243608
2021 Brain endothelial LRP1 maintains blood-brain barrier integrity. Fluids and barriers of the CNS 35 34147102
2010 Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. The Journal of biological chemistry 34 20472562
2005 Cooperative binding of the leucine-responsive regulatory protein (Lrp) to DNA. Journal of molecular biology 34 15571719
2000 LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis. Microscopy research and technique 34 10936878
2017 Role of Vitamin D in Amyloid clearance via LRP-1 upregulation in Alzheimer's disease: A potential therapeutic target? Journal of chemical neuroanatomy 33 28669880
2010 Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. Journal of immunology (Baltimore, Md. : 1950) 33 21048103
2008 Phylogenetic conservation of glycoprotein 96 ability to interact with CD91 and facilitate antigen cross-presentation. Journal of immunology (Baltimore, Md. : 1950) 33 18292541
2006 Possible role of LRP1, a CCN2 receptor, in chondrocytes. Biochemical and biophysical research communications 32 16690029
2014 Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91. Nutrition (Burbank, Los Angeles County, Calif.) 31 25220876
2003 Modulation of the LDL receptor and LRP levels by HIV protease inhibitors. Journal of lipid research 31 12837856
2020 TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1. Scientific reports 30 32694578
2013 Establishment of tumor-associated immunity requires interaction of heat shock proteins with CD91. Cancer immunology research 30 24778318
2008 Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica 30 18166789
2011 Association of ApoE and LRP mRNA levels with dementia and AD neuropathology. Neurobiology of aging 29 21676498
2011 Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1). Journal of hepatology 29 21703209
2015 Knockdown of LRP/LR Induces Apoptosis in Breast and Oesophageal Cancer Cells. PloS one 28 26427016
2014 Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status. Reproduction (Cambridge, England) 28 24947444
2007 Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development. Development (Cambridge, England) 28 17409116
2005 Immune function of C1q and its modulators CD91 and CD93. Critical reviews in immunology 28 16167883
2021 The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages. Acta pharmaceutica Sinica. B 27 35127380
2016 LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes. The Journal of biological chemistry 27 27317662
2013 Influence of LRP-1 and apolipoprotein E on amyloid-β uptake and toxicity to cerebrovascular smooth muscle cells. Journal of Alzheimer's disease : JAD 27 22914594
2023 Multi-faceted role of LRP1 in the immune system. Frontiers in immunology 26 37020553
2022 LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB). Signal transduction and targeted therapy 26 35680846
2004 Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors. Investigative ophthalmology & visual science 26 15161872
2017 Identification of LRP-1 as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells. Oncotarget 25 29108253
2022 Secreted HSP90α-LRP1 Signaling Promotes Tumor Metastasis and Chemoresistance in Pancreatic Cancer. International journal of molecular sciences 24 35628341
2022 Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM). Molecules (Basel, Switzerland) 24 36235232