Affinage

SLIT2

Slit homolog 2 protein · UniProt O94813

Length
1529 aa
Mass
169.9 kDa
Annotated
2026-06-10
100 papers in source corpus 43 papers cited in narrative 43 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLIT2 is a large secreted glycoprotein that functions as a guidance and motility-regulating cue, originally defined as a chemorepellent that collapses olfactory and hippocampal axon growth cones through the Robo1 and Robo2 receptors in the developing forebrain (PMID:10197527). It is proteolytically processed in vivo into a Robo-binding N-terminal fragment (Slit2-N) and a C-terminal fragment (Slit2-C); only Slit2-N and the uncleaved form bind Robo and drive repulsion and growth-cone collapse, whereas the uncleaved form antagonizes Slit2-N-induced axon branching, establishing that fragment identity dictates output (PMID:11404413). Heparan sulfate is an obligatory cofactor, and the structurally dimerizing D4 domain both binds heparan sulfate and is sufficient to collapse growth cones (PMID:19498462, PMID:16423696). Growth-cone repulsion proceeds through local protein synthesis, endocytosis, MAPK activation, and cofilin-mediated F-actin depolymerization (PMID:16423696), converging on a core mechanism in which Slit2/Robo signaling reorganizes the actin cytoskeleton by controlling Rho-family GTPases—suppressing Cdc42 and Rac in repulsive contexts via srGAP1, with PI3K and Src kinases physically associated with Robo (PMID:15007828, PMID:19759280, PMID:31084928). The same Rho-GTPase logic underlies SLIT2's role as a broad suppressor of directed cell motility and inflammation: it blocks chemoattractant-driven chemotaxis of neutrophils, T cells and monocytes by inhibiting Cdc42/Rac2 and CXCR4-coupled signaling (PMID:19759280, PMID:17565045), with cell-type-specific outcomes set by srGAP1 levels (PMID:20944010). Through Robo4, SLIT2 stabilizes vasculature by assembling a Robo4-paxillin complex that recruits GIT1 to block Arf6 and Rac, limiting endothelial protrusion and inflammation (PMID:19855388, PMID:24272999), and it inhibits platelet adhesion via suppression of Akt (PMID:22865890) and restrains macropinocytosis to dampen NOD2/NF-κB inflammatory signaling (PMID:32807784). SLIT2 also acts in tissue homeostasis and disease beyond neurons: Slit2-C drives PKA-dependent adipose thermogenesis (PMID:26876562), SLIT2/ROBO2 destabilizes podocyte adhesion by inhibiting nonmuscle myosin IIA through SRGAP1 (PMID:27882344), and SLIT2/ROBO1 controls mammary stem-cell division orientation via SNAI1/mINSC (PMID:26440891). In angiogenesis and cancer its effects are strongly context- and receptor-dependent: it can promote endothelial migration and Rac1-dependent angiogenesis through Robo1/Robo2 (PMID:25894826, PMID:26244297), while acting as a tumor suppressor of migration and invasion in glioma and pancreatic cancer through Robo1-mediated Cdc42 suppression (PMID:20008733, PMID:24448236), with the net pro- versus anti-metastatic outcome determined by the cellular source of SLIT2 (PMID:32999457).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1999 High

    Established SLIT2's foundational function by showing the human protein directly repels axons and collapses growth cones through Robo receptors, defining the Slit-Robo guidance axis in mammals.

    Evidence Collagen gel repulsion and growth cone collapse assays with recombinant human Slit2 on olfactory and hippocampal axons

    PMID:10197527

    Open questions at the time
    • Did not resolve downstream cytoskeletal effectors
    • Receptor binding inferred functionally, not structurally
  2. 2001 High

    Resolved that SLIT2 is proteolytically processed and that Robo binding and distinct activities partition between fragments, showing fragment identity determines repulsion versus branching outputs.

    Evidence Robo binding assays and functional repulsion/branching assays with engineered truncated and cleavage-site mutant Slit2

    PMID:11404413

    Open questions at the time
    • Protease responsible for in vivo cleavage not identified
    • Mechanism of full-length antagonism unresolved
  3. 2006 High

    Defined the downstream machinery of growth-cone repulsion, showing it requires local protein synthesis, endocytosis, MAPK activation, and cofilin-driven actin depolymerization, and depends on heparan sulfate.

    Evidence Pharmacological perturbation and cofilin/F-actin immunostaining in Xenopus retinal growth cones

    PMID:16423696

    Open questions at the time
    • Identity of locally synthesized proteins not defined
    • Link from MAPK to cofilin not mapped
  4. 2009 High

    Provided structural and biochemical basis for SLIT2 dimerization and heparan-sulfate dependence, with the D4 domain sufficient to collapse growth cones.

    Evidence X-ray crystallography of Slit2 D4, heparan sulfate binding, and chick retinal ganglion cell collapse assay

    PMID:19498462

    Open questions at the time
    • No structure of the Slit2-Robo complex
    • Functional role of dimerization in vivo untested
  5. 2009 High

    Extended SLIT2 function beyond neurons by showing it suppresses leukocyte chemotaxis through Robo1-dependent inhibition of Cdc42/Rac without blocking major kinase pathways, establishing an anti-inflammatory role.

    Evidence Live-cell tracking, actin barbed-end and GTPase activation assays, and mouse peritonitis models

    PMID:19759280

    Open questions at the time
    • srGAP coupling to Robo1 not directly shown here
    • Selectivity for directed versus random motility mechanism incomplete
  6. 2009 High

    Identified a Robo4-specific vascular-stabilizing mechanism, showing SLIT2 assembles a Robo4-paxillin complex that recruits GIT1 to block Arf6 and Rac, distinct from Robo1/2 neuronal signaling.

    Evidence Co-IP of Robo4 with paxillin, Arf6/Rac activation assays, and in vivo neovascularization models

    PMID:19855388

    Open questions at the time
    • How Robo4 selects this complex over Robo1/2 outputs unclear
    • Direct GAP activity of GIT1 on Arf6 in this context inferred
  7. 2010 Medium

    Showed cell-context determines SLIT2 output, with srGAP1 abundance switching Robo1 signaling between Cdc42 activation (eosinophils) and inactivation (neutrophils).

    Evidence srGAP1 expression profiling, PI3K-Robo1 Co-IP, Cdc42 assays, and in vivo airway eosinophil models

    PMID:20944010

    Open questions at the time
    • Single lab
    • Quantitative srGAP1 threshold not defined
  8. 2012 High

    Demonstrated SLIT2 directly inhibits platelet function, broadening its anti-adhesive role to hemostasis via Akt suppression.

    Evidence Robo1 detection, microfluidic adhesion and Akt assays, and murine bleeding/arterial-injury models

    PMID:22865890

    Open questions at the time
    • Upstream link from Robo1 to Akt not mapped
    • Which Slit2 fragment is active not tested
  9. 2016 High

    Uncovered a fragment- and receptor-independent metabolic function, showing Slit2-C drives PKA-dependent adipose thermogenesis distinct from Robo-mediated repulsion.

    Evidence Proteomic fragment identification, in vivo Slit2-C administration, and PKA inhibition with metabolic phenotyping

    PMID:26876562

    Open questions at the time
    • Receptor/coupling for Slit2-C-PKA signaling unidentified
    • Protease generating Slit2-C in adipose tissue undefined
  10. 2016 High

    Defined a renal mechanism in which SLIT2/ROBO2 destabilizes podocyte adhesion by forming a ROBO2/SRGAP1/NMIIA complex that inhibits nonmuscle myosin IIA.

    Evidence Co-IP of MRLC with SRGAP1/ROBO2, focal adhesion and adhesion assays, and podocyte-specific Robo2 knockout mice

    PMID:27882344

    Open questions at the time
    • How SRGAP1 connects to NMIIA enzymatically not fully resolved
    • Relevance to human kidney disease inferred from mouse
  11. 2015 High

    Showed SLIT2/Robo1/Robo2 can promote rather than restrain angiogenesis, being required for Slit2- and VEGF-induced Rac1 activation and endothelial lamellipodia, demonstrating context-dependent vascular outputs.

    Evidence Conditional Slit2/Robo1/Robo2 knockouts, retinal vascular analysis, and Rac1/lamellipodia assays

    PMID:25894826

    Open questions at the time
    • Reconciliation with Robo4 anti-angiogenic role incomplete
    • Direct VEGFR crosstalk mechanism not defined here
  12. 2020 High

    Resolved the apparent paradox of SLIT2 in cancer by showing its pro- versus anti-metastatic effect depends on cellular source, with endothelial SLIT2 promoting and tumoral SLIT2 suppressing metastasis.

    Evidence Compartment-specific conditional Slit2 deletion in breast/lung cancer models and TLR3-driven endothelial induction

    PMID:32999457

    Open questions at the time
    • Why identical ligand yields opposite outcomes by source mechanistically incomplete
    • Receptor expression differences across compartments not fully dissected
  13. 2020 High

    Identified SLIT2 as an inhibitor of macropinocytosis that limits innate inflammatory signaling, linking cytoskeletal control to NOD2/NF-κB suppression.

    Evidence Macropinocytosis assays in macrophages and RAS-transformed cells, in vivo administration, and CXCL1/NF-κB readouts

    PMID:32807784

    Open questions at the time
    • Which Robo receptor mediates the effect not pinned down
    • Direct cytoskeletal effector for macropinosome closure unspecified
  14. 2023 Medium

    Began mapping intracellular Robo1 signaling complexes in cancer, identifying a SLIT2-enhanced ROBO1-NEK9 axis that phosphorylates TRIM28 and cortactin to drive cytoskeletal remodeling.

    Evidence Mass spectrometry of ROBO1 interactors, Co-IP, in vitro kinase and transcriptional assays, and metastasis models

    PMID:37443302

    Open questions at the time
    • Single lab
    • Generality of NEK9 coupling beyond gastric cancer untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the choice between SLIT2's opposing outputs—repulsion versus attraction, pro- versus anti-angiogenic, tumor-suppressive versus metastasis-promoting—is encoded by fragment identity, receptor (Robo1/2/3/4) repertoire, srGAP1 levels, and cellular source remains unresolved at a unifying mechanistic level.
  • No integrated model linking fragment processing to receptor selection
  • Protease(s) governing in vivo cleavage context incompletely defined
  • Structural basis of receptor-specific signaling complexes unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0098772 molecular function regulator activity 3 GO:0008289 lipid binding 2
Localization
GO:0005576 extracellular region 5 GO:0031012 extracellular matrix 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 4
Partners
CCN2CXCR4NEK9ROBO1ROBO2ROBO4SRGAP1USP33
Complex memberships
ROBO2/SRGAP1/NMIIA complexRobo4-paxillin-GIT1 complex

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 Human Slit2 acts as a chemorepellent for olfactory and hippocampal axons and collapses their growth cones, functioning through Robo1 and Robo2 receptors in the developing forebrain. Collagen gel repulsion assay, growth cone collapse assay using recombinant human Slit2 Neuron High 10197527
2001 Slit2 is proteolytically cleaved in vivo into a 140 kDa N-terminal fragment (Slit2-N) and a 55-60 kDa C-terminal fragment (Slit2-C). Only Slit2-N (and uncleaved Slit2-U) bind Robo receptors. Slit2-N repels olfactory bulb axons and induces growth cone collapse, while only Slit2-N (not Slit2-C) induces DRG axon branching. The full-length uncleaved form antagonizes branching by Slit2-N. Binding assays with Robo proteins, collagen gel repulsion/attraction assays, growth cone collapse assay using engineered truncated and mutant Slit2 constructs The Journal of neuroscience High 11404413
2006 Slit2-induced growth cone collapse in Xenopus retinal neurons requires local protein synthesis and endocytosis; Slit2 activates MAP kinases and translation regulators in growth cones, and causes a protein-synthesis-dependent decrease in F-actin and increase in the actin-depolymerizing protein cofilin. Disruption of heparan sulfate blocks Slit2-induced protein synthesis and repulsion. Pharmacological inhibition of translation, endocytosis, MAPKs, and heparan sulfate; immunostaining for cofilin and F-actin in Xenopus retinal growth cones treated with Slit2-conditioned medium Neuron High 16423696
2007 Slit2 inhibits CXCL12-induced chemotaxis and transendothelial migration of T cells and monocytes. CXCR4 physically associates with Robo1, and Slit2 treatment enhances this association. The CC3 motif of Robo1 mediates interaction with CXCR4. Slit2 blocks CXCL12-induced activation of Src and Lck kinases, Akt phosphorylation, and Rac activation, but not MAPK activation. Co-immunoprecipitation of CXCR4 and Robo1; chemotaxis and transendothelial migration assays; Western blot for kinase activation; domain deletion mutants of Robo1 Journal of leukocyte biology Medium 17565045
2008 Slit-2 mediates tumor-suppressive effects in breast cancer cells through coordinated regulation of the β-catenin and PI3K signaling pathways and by enhancing β-catenin/E-cadherin-mediated cell-cell adhesion. Slit2 overexpression in MCF-7 cells; in vitro proliferation and migration assays; in vivo tumor growth in mouse models; Western blot for β-catenin and PI3K pathway components The Journal of biological chemistry Medium 18611862
2009 Slit2 promotes vascular stability through Robo4 by forming a Robo4-paxillin complex at the cell surface that blocks activation of Arf6 and consequently Rac, via recruitment of Arf-GAP GIT1. This inhibits cellular protrusive activity underlying neovascularization and vascular leak. Co-immunoprecipitation of Robo4 with paxillin/Hic-5; biochemical assays for Arf6 and Rac activation; Arf6 inhibition in vivo (choroidal/retinal neovascularization models); cell biological protrusion assays Nature cell biology High 19855388
2009 Slit2 inhibits glioma cell migration and invasion through Robo1-dependent suppression of Cdc42 activity. siRNA knockdown of Robo1 prevents Slit2-mediated Cdc42 inactivation and rescues cell migration inhibition. Cdc42 activity assay (GTP pull-down), Robo1 siRNA knockdown, modified Boyden chamber migration assay, in vivo intracranial tumor model Neuro-oncology Medium 20008733
2009 Slit2 crystal structure of the fourth domain (D4) reveals homodimerization using conserved residues on its concave face; D4 also binds heparan sulphate. Slit2 D4 causes growth cone collapse in chick retinal ganglion cells, which can be inhibited by exogenously added heparan sulphate. X-ray crystallography of Slit2 D4; heparan sulphate binding assay; chick retinal ganglion cell growth cone collapse assay EMBO reports High 19498462
2009 Slit2 inhibits directional migration (chemotaxis) but not random movement of neutrophils toward fMLP, C5a, and IL-8, acting through Robo1. Mechanistically, Slit2 suppresses chemoattractant-induced actin barbed-end formation, cell polarization, and activation of Cdc42 and Rac2, without impairing major kinase pathways. In vivo, Slit2 reduces neutrophil recruitment in mouse peritoneal inflammation models. Video-microscopic live cell tracking; actin barbed-end formation assay; Cdc42/Rac2 activation assays; mouse peritoneal inflammation models; Robo1 expression confirmed by flow cytometry Journal of leukocyte biology High 19759280
2010 Slit2 differentially regulates eosinophil and neutrophil chemotaxis through differential expression of srGAP1. In eosinophils (low srGAP1), Slit2/Robo1 activates Cdc42 and recruits PI3K to Robo1, enhancing eotaxin-induced chemotaxis. In neutrophils (high srGAP1), srGAP1 binding to Robo1 leads to Cdc42 inactivation and repulsion. Aerosol Slit2 accelerates eosinophil infiltration, while IV Slit2 reduces it. Measurement of srGAP1 expression in eosinophils vs neutrophils; PI3K recruitment to Robo1 by co-immunoprecipitation; Cdc42 activity assays; in vivo aerosol/IV Slit2 administration in OVA-sensitized mice; siRNA blockade of srGAP1 Journal of immunology Medium 20944010
2011 Slit-2 repels olfactory ensheathing cell (OEC) migration via Robo receptor. The repulsion requires Ca2+ release from internal stores through IP3 receptor channels. Slit-2-induced collapse of the leading front requires Ca2+-dependent cofilin activation (F-actin severing), while soma reversal requires spatial reversal of RhoA activity across the cell. Live cell imaging of OEC migration; Ca2+ imaging; pharmacological inhibition of IP3 receptors, cofilin, and RhoA/ROCK; immunostaining of cofilin activation Journal of cell science Medium 21187345
2012 Slit2 is a potent inhibitor of platelet function. Robo1 is expressed on human and murine platelets and megakaryocytes. Slit2 impairs platelet adhesion and spreading by suppressing Akt activation, prevents platelet activation by ADP, prolongs bleeding times in vivo, delays vessel occlusion after arterial injury, and prevents stable occlusive thrombus formation. Immunofluorescence microscopy and flow cytometry for Robo1; static and shear microfluidic adhesion assays; Akt activation assays; murine tail bleeding and intravital microscopy models of arterial injury Circulation High 22865890
2012 Slit2 and Robo3 directly modulate migration of GnRH neurons. Mice lacking Slit2 or Robo3 have a reduced number of GnRH neurons reaching the forebrain but normal complement of their axonal substrates, indicating a direct role on the neurons rather than via axonal patterning. Genetic knockout mouse models for Slit2 and Robo3; quantification of GnRH neuron numbers and axon patterns Development Medium 22912413
2013 Slit2-Robo4 signaling represses LPS-induced endothelial inflammation (cytokine secretion, ICAM-1 upregulation, monocyte adhesion) by inhibiting the Pyk2-NF-κB pathway downstream of TLR4. Robo1 has proinflammatory properties and is downregulated by Slit2 via miR-218. siRNA knockdown of Robo1 and Robo4 in HUVECs; cytokine/ICAM-1 measurement; NF-κB and Pyk2 phosphorylation assays; monocyte adhesion assay Journal of immunology Medium 24272999
2014 SLIT2 inhibits directed motility of pancreatic ductal adenocarcinoma cells through autocrine/paracrine ROBO1-mediated signaling. Restoring SLIT2 expression inhibits neural invasion and PDAC cell navigation along neurites; ROBO1 silencing in SLIT2-competent cells stimulates motility. Conditioned medium from SLIT2-competent PDAC cells impairs endothelial migration, but an N-terminal SLIT2 cleavage fragment stimulates it. SLIT2 restoration by transfection; ROBO1 siRNA knockdown; neural co-culture invasion assay; migration assays; in vivo tumor model Cancer research Medium 24448236
2014 Fibroblasts from healthy human tissues secrete Slit2, which inhibits monocyte-to-fibrocyte differentiation. In mice, injections of Slit2 inhibit bleomycin-induced lung fibrosis. Slit2 identification in fibroblast conditioned medium; fibrocyte differentiation assays with recombinant Slit2; in vivo bleomycin fibrosis model with Slit2 injections PNAS Medium 25489114
2015 Slit2 signals through Robo1 and Robo2 to promote retinal angiogenesis in vivo. Slit2/Robo1/Robo2 signaling promotes endothelial cell migration and is required for both Slit2- and VEGF-induced Rac1 activation and lamellipodia formation. Conditional knockout mice for Slit2, Robo1, Robo2 (individual and combined); postnatal retinal vascular analysis; ocular neovascular disease model; Rac1 activation and lamellipodia assays in endothelial cells Nature medicine High 25894826
2015 SLIT2/ROBO1 signaling regulates mammary stem cell self-renewal by governing the choice between asymmetric and symmetric cell divisions through the transcription factor SNAI1 and the spindle orientation protein mINSC. Loss of SLIT2/ROBO1 signaling increases nuclear SNAI1, which upregulates mInsc and shifts cap cells toward symmetric divisions, expanding the stem cell pool. Slit2/Robo1 knockout mouse mammary gland analysis; SNAI1 overexpression; mInsc expression measurement; cell division orientation quantification; rescue by SLIT2 treatment Cell reports Medium 26440891
2015 Slit2 serves as a β-catenin (Ctnnb1)-dependent retrograde signal from muscle to direct presynaptic (motoneuron) differentiation at the neuromuscular junction. Muscle-specific Ctnnb1 mutant lacking the transactivation domain fails to rescue presynaptic deficits. Transgenic Slit2 expression in muscle rescues presynaptic deficits caused by Ctnnb1 mutation. Slit2 immobilized on beads induces synaptophysin puncta in spinal cord axons. In vivo transgenic rescue experiments; bead-immobilized Slit2 applied to spinal cord explants; NMJ morphological analysis eLife Medium 26159615
2015 Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway: Slit2/Robo1 activates Src signaling, which downregulates E-cadherin, thereby activating Wnt/β-catenin. Slit2 transgenic mice crossed with ApcMin/+ and DMH/DSS colorectal carcinoma models; Western blot for Src, E-cadherin, β-catenin; in vitro signaling assays Oncotarget Medium 25605242
2015 CAF-secreted SLIT2 increases neurite outgrowth from dorsal root ganglia neurons and Schwann cell migration/proliferation through modulation of N-cadherin/β-catenin signaling. SLIT2/ROBO inhibition disrupts the stromal/neural connection. Co-culture of CAFs with DRG neurons; neurite outgrowth measurement; Schwann cell migration/proliferation assays; SLIT2/ROBO signaling inhibition; N-cadherin/β-catenin Western blot Cell death & disease Medium 25590802
2016 Full-length Slit2 is cleaved to generate smaller fragments in adipose tissue and in mice. The C-terminal fragment (Slit2-C, ~50 kDa) is the active thermogenic moiety that promotes adipose thermogenesis and augments energy expenditure. Mechanistically, Slit2 induces robust PKA signaling activation, which is required for its prothermogenic activity. Proteomics identification of Slit2 fragments; in vivo administration of Slit2-C fragment; PKA signaling assays; pharmacological inhibition of PKA; metabolic phenotyping in mice Cell metabolism High 26876562
2016 SLIT2/ROBO2 signaling inhibits nonmuscle myosin IIA (NMIIA) activity and destabilizes kidney podocyte adhesion through SRGAP1. The myosin II regulatory light chain (MRLC) directly interacts with SRGAP1, and SLIT2 treatment promotes formation of a ROBO2/SRGAP1/NMIIA complex. SLIT2 stimulation decreases focal adhesion formation and reduces podocyte attachment to collagen. Podocyte-specific Robo2 knockout protects mice from hypertension-induced podocyte detachment. Co-immunoprecipitation of MRLC with SRGAP1 and ROBO2; NMIIA activity assays; focal adhesion staining; collagen adhesion assays; podocyte-specific Robo2 conditional knockout mice JCI insight High 27882344
2018 Slit2/Robo1 signaling promotes liver fibrosis through activation of hepatic stellate cells (HSCs). In HSCs, Robo1 neutralizing antibody and Robo1 siRNA downregulate phosphorylation of Smad2, Smad3, PI3K, and AKT independently of TGF-β1, and inhibit α-SMA expression. Primary mouse HSCs and LX-2 human HSC line treated with Slit2/Robo1 manipulations; Western blot for Smad2/3, PI3K, AKT; Slit2 transgenic and Robo1/2+/- mice with CCl4-induced fibrosis Journal of hepatology Medium 26264936
2018 USP33 deubiquitinates and stabilizes Robo1, thereby enhancing Slit2-Robo1 inhibitory signaling in gastric cancer cells. Co-IP analysis confirmed the interaction between Robo1 and USP33; ubiquitination analysis showed USP33 reduces Robo1 ubiquitination. Co-immunoprecipitation of Robo1 and USP33; ubiquitination assay; migration and EMT assays after USP33 manipulation Cell proliferation Medium 30896071
2018 CAPN5 directly cleaves SLIT2 in photoreceptors in vitro to generate SLIT2-N and SLIT2-C fragments. CAPN5 interacts with SLIT2 in retinal photoreceptors by co-immunoprecipitation. Increased CAPN5-mediated SLIT2 cleavage and secretion promotes PKA activation and proliferation in retinal pigment epithelium cells. In vitro cleavage assay (CAPN5 + SLIT2); co-immunoprecipitation in 661W cells; conditioned medium experiments; PKA activation by immunofluorescence and Western blot; CAPN5 knock-in mouse Investigative ophthalmology & visual science Medium 29610848
2018 SLIT2 (expressed by CD34- orbital fibroblasts) attenuates the inflammatory phenotype of CD34+ fibrocytes in Graves' disease orbit. Conditioned medium from CD34- fibroblasts reduces MHC-2, thyroglobulin, TSHR, and AIRE expression in fibrocytes; depleting the medium of Slit2 reverses these effects. Recombinant human Slit2 mimics these effects. TSH induces Slit2 expression in GD-OF by enhancing both gene transcription and mRNA stability. Conditioned medium experiments with Slit2 depletion by antibody; recombinant Slit2 treatment; gene expression analysis; TSH stimulation experiments Journal of immunology Medium 29752312
2018 Direct negative cross-talk exists between SLIT2 and BMP-Gremlin signaling pathways: the SLIT2-Gremlin interaction inhibits both SLIT2-ROBO2 signaling in neurons and Gremlin antagonism of BMP activity. BMP2 downregulates SLIT2 expression and promoter activity through canonical BMP/SMAD signaling; Gremlin treatment, BMP receptor inhibition, and SMAD4 knockdown rescue this repression. SLIT2-Gremlin binding assay; SLIT2-ROBO2 neuronal signaling assay; BMP activity assay in myoblasts; SLIT2 promoter-reporter assay; SMAD4 siRNA knockdown; BMP2 treatment of nephron progenitor cells The Journal of biological chemistry Medium 29317497
2019 SLIT2 inhibits osteoclastogenesis and bone resorption through ROBO1-mediated suppression of Cdc42 activity. Binding ELISA confirmed SLIT2 directly binds ROBO1 (not ROBO3) in bone marrow-derived macrophages. Robo1 siRNA blocks SLIT2-mediated suppression of osteoclastogenesis. Cdc42 overexpression reverses SLIT2-mediated inhibition. Binding ELISA for SLIT2-ROBO1 interaction; Cdc42 activity assay; Robo1 siRNA knockdown; osteoclast differentiation and bone resorption assays; Cdc42 overexpression rescue Biochemical and biophysical research communications Medium 31084928
2020 Tumor cell-derived double-stranded RNA activates TLR3 in endothelial cells to induce SLIT2 expression. Endothelial-derived SLIT2 and its receptor ROBO1 on tumor cells promote cancer cell migration toward endothelial cells and intravasation. Deleting endothelial Slit2 suppresses metastasis, while deleting tumoural Slit2 enhances it, demonstrating that the same gene can promote or suppress cancer depending on its cellular source. Genetically tagged endothelial ribosome profiling; conditional endothelial and tumor-specific Slit2 deletion in mouse breast/lung cancer models; TLR3 activation studies; in vitro migration assays; endogenous retroviral element RNA detection Nature High 32999457
2020 SLIT2 inhibits macropinocytosis in macrophages and RAS-transformed cancer cells by inducing cytoskeletal changes via Roundabout receptors. In vivo, SLIT2 attenuates muramyl dipeptide uptake, preventing NOD2-dependent NF-κB activation and CXCL1 secretion. Blocking endogenous SLIT2 enhances CXCL1 secretion. Macropinocytosis assays in macrophages and RAS-transformed cells; in vivo SLIT2 administration; NOD2/NF-κB pathway readouts; endogenous SLIT2 blocking experiments; CXCL1 measurement Nature communications High 32807784
2021 SLIT2 promotes microglia/macrophage chemotaxis and tumor-supportive polarization in glioblastoma via ROBO1- and ROBO2-mediated PI3K-γ activation. Macrophage Robo1 and Robo2 deletion and systemic SLIT2 trap delivery mimic SLIT2 knockdown effects on tumor growth and the tumor microenvironment. SLIT2 knockdown in mouse glioma cells; macrophage-specific Robo1/Robo2 deletion; PI3K-γ activation assays; SLIT2 trap systemic delivery; tumor growth and immune profiling The Journal of clinical investigation High 34181595
2021 Slit2 reduces breast cancer metastasis by activating M1-like tumor-associated macrophages (TAMs) and enhancing their phagocytosis of tumor cells via suppression of IL-6. Slit2 also diminishes tumor fibrosis by increasing matrix metalloproteinase 13 expression in M1-TAMs. Slit2 overexpression in syngeneic and xenograft mammary tumor models; in vitro and in vivo phagocytosis assays; IL-6 manipulation; MMP13 expression analysis; macrophage polarization assays Cancer research Medium 34400395
2022 IGF2BP3 (an m6A reader) promotes TNBC metastasis by binding to and destabilizing m6A-methylated SLIT2 mRNA, thereby impairing SLIT2/ROBO1 downstream signaling and activating PI3K/AKT and MEK/ERK pathways. RNA m6A modification analysis; IGF2BP3 binding to SLIT2 mRNA; mRNA stability assays; pathway activation by Western blot; in vivo xenograft metastasis model FASEB journal Medium 36250924
2023 CAF-derived SLIT2 promotes gastric cancer metastasis by binding ROBO1, which interacts with serine/threonine kinase NEK9 (identified by mass spectrometry). SLIT2 enhances ROBO1-NEK9 binding. NEK9 kinase domain interacts with ROBO1 intracellular domain. NEK9 directly phosphorylates TRIM28 and cortactin (CTTN). TRIM28 acts as a transcriptional elongation factor and, together with STAT3 and NF-κB p100, drives CTTN transcription, inducing cytoskeletal reorganization. Mass spectrometry identification of ROBO1 interactors; Co-IP of ROBO1 and NEK9; domain deletion analysis; in vitro kinase assay for NEK9 phosphorylation of TRIM28 and CTTN; transcriptional assays; in vitro and in vivo metastasis models Cell death & disease Medium 37443302
2023 SLIT2-ROBO1 axis facilitates liver metastasis of PDAC through 'coadaptation' dependent on the dependence receptor (DR) characteristics of ROBO1. A neutralizing antibody targeting ROBO1 significantly attenuates PDAC liver metastasis by preventing the coadaptation effect. Mouse PDAC metastasis model with CT/3D bioluminescence imaging; ROBO1 dependence receptor characterization; ROBO1-neutralizing antibody treatment Nature communications Medium 36792623
2016 ISL1-based LIM complexes (ISL1-LHX3 and ISL1-LHX4) bind to the Slit2 enhancer and drive endogenous Slit2 expression in somatic motor neurons and branchiomotor neurons. Loss of Isl1 results in near-complete absence of Slit2 transcript in brainstem motor neurons and causes cranial motor neuron positioning and axon guidance defects. ChIP-seq analysis showing ISL1 binding to Slit2 enhancer; Isl1 conditional knockout mice; in situ hybridization and immunostaining for Slit2; luciferase reporter assay for Slit2 enhancer Scientific reports Medium 27819291
2004 EphrinA5 and slit2 both induce growth cone collapse in chick retinal ganglion cells through shared pathways (PI3K and Src family kinases) but diverge in that non-classical PKC isoforms are required for ephrinA5-mediated but not slit2-mediated collapse. PI3K and Src family kinases are co-purified by affinity chromatography with the slit2 receptor Roundabout. Pharmacological inhibition of PI3K, Src, and PKC in chick retinal ganglion cell growth cone collapse assay; affinity chromatography of Roundabout with PI3K; colocalization of Src and Roundabout Journal of neurobiology Medium 15007828
2020 NADPH oxidase 2 (Nox2) acts downstream of slit2/Robo2 in retinal ganglion cell axon guidance. Slit2-mediated growth cone collapse, axonal retraction, and repulsive turning are eliminated by Nox inhibition. Slit2 treatment increases growth cone hydrogen peroxide levels via Nox2 activation. In vivo, astray/nox2 double heterozygotes show decreased retinotectal innervation, suggesting genetic interaction. Pharmacological Nox inhibition; ROS biosensor imaging in growth cones; Nox2 mutant zebrafish; double heterozygote genetic interaction analysis; in vitro growth cone collapse and turning assays Developmental neurobiology Medium 33191581
2015 Slit2 promotes angiogenesis in endothelial cells via the Robo1-VEGFR2-ERK1/2 pathway. Slit2 overexpression upregulates Robo1, VEGFR2, and phosphorylated ERK1/2 in HUVECs and in laser-treated transgenic mouse retina/choroid, promoting endothelial proliferation, migration, and tube formation. Slit2 overexpression in HUVECs; laser-induced CNV in Slit2 transgenic mice; Western blot for VEGFR2 and p-ERK1/2; proliferation, migration, tube formation assays Investigative ophthalmology & visual science Medium 26244297
2018 Slit2/Robo1 signaling promotes angiogenesis in glomerular endothelial cells under diabetic conditions through the PI3K/Akt/VEGF pathway. Robo1 siRNA suppresses PI3K/Akt and VEGF activation; PI3K inhibitor blocks VEGF but not Robo1 expression, placing Robo1 upstream of PI3K/Akt. Slit2 siRNA in mesangial cells; conditioned medium on glomerular endothelial cells; Robo1 siRNA; PI3K inhibitor; Western blot for PI3K/Akt/VEGF/HIF-1α; proliferation, migration, tube formation assays Angiogenesis Medium 29299781
2020 Slit2-Robo1 signaling promotes cardiac fibrosis through crosstalk with the TGF-β1/Smad pathway. Recombinant Slit2 activates TGF-β1/Smad signaling in cardiac fibroblasts and upregulates collagen I and periostin; Slit2 siRNA downregulates Smad2/3 and collagen I. Recombinant Slit2 treatment of cardiac fibroblasts; Slit2 siRNA and TGF-β1 siRNA; Western blot for Smad2/3, collagen I, PI3K/Akt; TAC mouse model; Robo1 antagonist R5 ESC heart failure Medium 33236535
2022 CCN2/CTGF directly interacts with the 7th-9th EGF repeats and C-terminal cysteine knot motif of Slit2 in hepatic stellate cells and fibrotic livers. CCN2/CTGF and Slit2 synergistically activate PI3K/AKT in primary HSCs, and soluble Robo1-Fc chimera inhibits these activities. Co-immunoprecipitation and domain mapping of CCN2/CTGF with Slit2; PI3K/AKT activation assays; Robo1-Fc inhibition; Ccn2/Ctgf conditional knockout mice with CCl4 fibrosis Journal of cell communication and signaling Medium 36469291

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer research 243 21385904
2006 Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones. Neuron 230 16423696
1999 Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron 224 10197527
2002 SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer research 202 12384551
2009 Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nature cell biology 196 19855388
2015 Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization. Nature medicine 159 25894826
2016 A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell metabolism 130 26876562
2001 Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. The Journal of neuroscience : the official journal of the Society for Neuroscience 125 11404413
2020 Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis. Nature 123 32999457
2003 Frequent epigenetic inactivation of the SLIT2 gene in gliomas. Oncogene 115 12881718
2014 Axon guidance factor SLIT2 inhibits neural invasion and metastasis in pancreatic cancer. Cancer research 110 24448236
2005 Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Molecular and cellular neurosciences 106 15737744
2007 Slit2 involvement in glioma cell migration is mediated by Robo1 receptor. Journal of neuro-oncology 105 17968499
2021 SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia. The Journal of clinical investigation 101 34181595
2008 Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells. The Journal of biological chemistry 95 18611862
2007 Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells. Journal of leukocyte biology 93 17565045
2015 Activation of Slit2-Robo1 signaling promotes liver fibrosis. Journal of hepatology 82 26264936
2013 Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia. Journal of immunology (Baltimore, Md. : 1950) 80 24272999
2014 Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis. Proceedings of the National Academy of Sciences of the United States of America 79 25489114
2009 Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity. Neuro-oncology 79 20008733
2015 Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling. Cell death & disease 77 25590802
2009 The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils. Journal of leukocyte biology 75 19759280
2003 Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. Journal of immunology (Baltimore, Md. : 1950) 75 14662852
2005 Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. The European journal of neuroscience 73 16262652
2001 Expression of slit-2 and slit-3 during chick development. Developmental dynamics : an official publication of the American Association of Anatomists 72 11668607
2010 The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer. Oncogene 68 20622896
2021 Slit2 Inhibits Breast Cancer Metastasis by Activating M1-Like Phagocytic and Antifibrotic Macrophages. Cancer research 65 34400395
2014 Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nature communications 63 25030704
2010 Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. Journal of immunology (Baltimore, Md. : 1950) 57 20944010
2008 Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma. Neoplasia (New York, N.Y.) 54 19048120
2016 SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI insight 50 27882344
2024 Exosomal miR-4745-5p/3911 from N2-polarized tumor-associated neutrophils promotes gastric cancer metastasis by regulating SLIT2. Molecular cancer 49 39272149
2019 Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2. PLoS genetics 49 31194736
2010 Slit2/Robo1 signaling in glioma migration and invasion. Neuroscience bulletin 48 21113198
2004 SLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma. British journal of cancer 48 14735202
2015 Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation. eLife 47 26159615
2019 Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT. Cell proliferation 46 30896071
2009 Frequent epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic leukemia. Epigenetics 46 19550140
2020 SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling. Nature communications 44 32807784
2015 Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC. Cell reports 44 26440891
2023 Cancer associated fibroblast derived SLIT2 drives gastric cancer cell metastasis by activating NEK9. Cell death & disease 41 37443302
2017 Slit2 suppresses endothelial cell proliferation and migration by inhibiting the VEGF-Notch signaling pathway. Molecular medicine reports 41 28260032
2015 SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. Journal of cellular and molecular medicine 40 25786906
2013 Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer. Oncology reports 40 23381221
2015 Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway. Oncotarget 39 25605242
2008 Epigenetic inactivation of SLIT2 in human hepatocellular carcinomas. Biochemical and biophysical research communications 38 19100240
2018 Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment. Angiogenesis 36 29299781
2015 Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies. Investigative ophthalmology & visual science 36 26244297
2018 Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease. Journal of immunology (Baltimore, Md. : 1950) 35 29752312
2009 Structure and functional relevance of the Slit2 homodimerization domain. EMBO reports 35 19498462
2008 Regulation of osteoblast differentiation by slit2 in osteoblastic cells. Cells, tissues, organs 35 19033678
2012 The cell motility modulator Slit2 is a potent inhibitor of platelet function. Circulation 34 22865890
2021 Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling. Hepatology (Baltimore, Md.) 33 34490644
2020 Slit2/Robo1 Mitigates DSS-induced Ulcerative Colitis by Activating Autophagy in Intestinal Stem Cell. International journal of biological sciences 33 32398956
2013 SLIT2 inhibits cell migration in colorectal cancer through the AKT-GSK3β signaling pathway. International journal of colorectal disease 33 23314850
2012 Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability. PLoS pathogens 31 22241990
2011 Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition. Journal of cell science 31 21187345
2022 RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30 36250924
2019 SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity. Biochemical and biophysical research communications 30 31084928
2015 miR-1179 promotes cell invasion through SLIT2/ROBO1 axis in esophageal squamous cell carcinoma. International journal of clinical and experimental pathology 30 25755718
2023 Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma. Nature communications 29 36792623
2015 Increased permeability of the blood-brain barrier and Alzheimer's disease-like alterations in slit-2 transgenic mice. Journal of Alzheimer's disease : JAD 29 25114073
2013 Knockdown of Slit2 promotes growth and motility in gastric cancer cells via activation of AKT/β-catenin. Oncology reports 29 24297051
2012 Slit2 and Robo3 modulate the migration of GnRH-secreting neurons. Development (Cambridge, England) 29 22912413
2021 Enhancer RNA SLIT2 Inhibits Bone Metastasis of Breast Cancer Through Regulating P38 MAPK/c-Fos Signaling Pathway. Frontiers in oncology 28 34722297
2015 miR-218 inhibits the migration and invasion of glioma U87 cells through the Slit2-Robo1 pathway. Oncology letters 28 25789001
2011 Over-expression of Slit2 induces vessel formation and changes blood vessel permeability in mouse brain. Acta pharmacologica Sinica 28 21986575
2004 Convergent and divergent signaling mechanisms of growth cone collapse by ephrinA5 and slit2. Journal of neurobiology 28 15007828
2020 SLIT2 Overexpression in Periodontitis Intensifies Inflammation and Alveolar Bone Loss, Possibly via the Activation of MAPK Pathway. Frontiers in cell and developmental biology 27 32760720
2020 Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis. ESC heart failure 27 33236535
2018 Slit2-Robo2 signaling modulates the fibrogenic activity and migration of hepatic stellate cells. Life sciences 27 29660433
2022 CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling. Journal of cell communication and signaling 26 36469291
2005 Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs. Oncology reports 26 16211308
2023 Slit2/Robo1 signaling inhibits small-cell lung cancer by targeting β-catenin signaling in tumor cells and macrophages. Molecular oncology 25 35838343
2018 Slit2/Robo4 axis may contribute to endothelial cell dysfunction and angiogenesis disturbance in systemic sclerosis. Annals of the rheumatic diseases 25 30021803
2012 Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations. Cell cycle (Georgetown, Tex.) 25 22313734
2010 Potential anti-angiogenic role of Slit2 in corneal neovascularization. Experimental eye research 25 20298689
2016 Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes. International journal of oncology 24 27082735
2021 Slit2 Regulates Hyaluronan & Cytokine Synthesis in Fibrocytes: Potential Relevance to Thyroid-Associated Ophthalmopathy. The Journal of clinical endocrinology and metabolism 23 32968816
2020 The potential of Slit2 as a therapeutic target for central nervous system disorders. Expert opinion on therapeutic targets 23 32378435
2015 The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells. Journal of immunology (Baltimore, Md. : 1950) 23 26297762
2013 Slit2-Robo signaling: a novel regulator of vascular injury. Current opinion in nephrology and hypertension 23 23736842
2020 Slit2 May Underlie Divergent Induction by Thyrotropin of IL-23 and IL-12 in Human Fibrocytes. Journal of immunology (Baltimore, Md. : 1950) 21 32086386
2019 The role of Slit2 as a tumor suppressor in thyroid cancer. Molecular and cellular endocrinology 21 30648543
2017 Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury. Neuroreport 21 27893610
2017 Slit2 ameliorates renal inflammation and fibrosis after hypoxia-and lipopolysaccharide-induced epithelial cells injury in vitro. Experimental cell research 21 28163057
2015 Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4. Biochemical and biophysical research communications 21 26713366
2020 Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2. Developmental neurobiology 20 33191581
2016 Slit2 and Robo1 induce opposing effects on metastasis of hepatocellular carcinoma Sk-hep-1 cells. International journal of oncology 20 27176045
2021 Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling. Frontiers in cell and developmental biology 19 34660572
2018 Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. The Journal of biological chemistry 19 29317497
2013 Slit2-Robo4 receptor responses inhibit ANDV directed permeability of human lung microvascular endothelial cells. Antiviral research 19 23702092
2021 Raddeanin A inhibits proliferation, invasion, migration and promotes apoptosis of cervical cancer cells via regulating miR-224-3p/Slit2/Robo1 signaling pathway. Aging 18 33621954
2018 Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain. International journal of molecular medicine 18 30085336
2016 ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons. Scientific reports 18 27819291
2021 Slit2 is necessary for optic axon organization in the zebrafish ventral midline. Cells & development 17 33994352
2014 Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis. Laboratory investigation; a journal of technical methods and pathology 17 24840330
2013 Slit2 expression and its correlation with subcellular localization of β-catenin in gastric cancer. Oncology reports 16 23933755
2018 Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage. Investigative ophthalmology & visual science 15 29610848
2014 Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Molecular cancer research : MCR 15 25504371

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