Affinage

SENP1

Sentrin-specific protease 1 · UniProt Q9P0U3

Length
644 aa
Mass
73.5 kDa
Annotated
2026-06-10
100 papers in source corpus 51 papers cited in narrative 51 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SENP1 is a SUMO-specific cysteine protease that both matures SUMO precursors and reverses SUMO conjugation on hundreds of substrates, thereby acting as a master regulator of transcription, metabolism, DNA repair, immune signaling, and cell death (PMID:14563852, PMID:15487983). Catalytically, it processes SUMO-1, -2, and -3 precursors with its isolated catalytic domain dictating specificity, and it additionally hydrolyzes the thioester linkages of E1-SUMO and E2-SUMO intermediates; cleavage requires a substrate-induced conformational change in which binding of the SUMO β-grasp domain to a distal exosite allosterically activates the active site ~20 Å away (PMID:15487983, PMID:16712526, PMID:25263960). Its protease output is gated by redox and metal chemistry—a reactive thiol at C535 together with Zn2+ suppresses basal activity, and S-sulfhydration at C683 inhibits the enzyme—linking SENP1 activity to cellular redox state (PMID:36750014, PMID:38184650). SENP1 is predominantly nuclear via an N-terminal NLS, shuttles through a C-terminal NES, and is anchored at the nuclear pore complex by Nup153, a localization required for 53BP1 SUMOylation and non-homologous end joining (PMID:14563852, PMID:16253240, PMID:22688647, PMID:28576968); loss-of-function in mice causes global hyperSUMOylation, placental defects, and embryonic lethality, establishing deSUMOylation as essential for development (PMID:15923632). Functionally, SENP1 deSUMOylates and stabilizes HIF-1α in a hypoxia-driven positive feedback loop driving angiogenesis and tumor stemness (PMID:20841360, PMID:28258134), activates erythroid GATA1 to control erythropoiesis (PMID:20457756, PMID:27821551), and translocates into mitochondria upon AMPK activation during metabolic stress to deSUMOylate and activate Sirt3, reprogramming mitochondrial acetylation, fatty-acid oxidation, and immune-cell metabolism (PMID:31302001, PMID:34272364, PMID:35417703). It governs cell-death and inflammatory signaling by deSUMOylating RIPK1 within the TNF receptor complex, NEMO to restrain NF-κB, and MAVS to limit antiviral phase separation (PMID:36414671, PMID:34120412, PMID:37188808), and it counteracts SUMO-driven liquid-liquid phase separation of RNF168 to promote DNA repair (PMID:37350666). A de novo heterozygous truncating SENP1 mutation causes autistic-like behavior by destabilizing FMRP, a phenotype rescued by restoring SENP1 in the retrosplenial cortex (PMID:34731627).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2003 High

    Established SENP1 as a nuclear SUMO-specific protease whose catalytic cysteine is required to reverse SUMO-1 conjugation and whose activity and localization are internally autoregulated.

    Evidence NLS and active-site cysteine mutagenesis with dominant-negative overexpression and localization imaging

    PMID:14563852

    Open questions at the time
    • Did not define physiological substrates
    • Regulatory-domain suppression mechanism not structurally resolved
  2. 2005 High

    Defined the catalytic scope of SENP1, showing it both matures SUMO-1/-2/-3 precursors and that the catalytic domain alone confers substrate specificity.

    Evidence In vitro protease assays with recombinant SENP1 and SUMO precursor mutagenesis

    PMID:15487983

    Open questions at the time
    • In vitro efficiencies may not reflect cellular substrate preference
    • Did not address isopeptidase vs endopeptidase balance in cells
  3. 2005 High

    Demonstrated that SENP1 deSUMOylation is essential for mammalian development, linking enzyme loss to global hyperSUMOylation in vivo.

    Evidence Retroviral insertional mutagenesis in mice with SUMO-conjugate Western blots and embryonic phenotyping

    PMID:15923632

    Open questions at the time
    • Did not pinpoint which substrate(s) drive lethality
    • Insertional allele may be hypomorphic rather than null
  4. 2006 High

    Provided the structural basis for catalysis, revealing a required self-conformational change and an unexpected ability to cleave E1/E2-SUMO thioesters.

    Evidence X-ray crystallography of the SENP1-SUMO1 catalytic complex with in vitro activity assays

    PMID:16712526

    Open questions at the time
    • Static structure did not capture the activation dynamics
    • Physiological role of thioester hydrolysis not established
  5. 2014 High

    Resolved how substrate binding activates SENP1, showing the SUMO β-grasp domain triggers allosteric activation at a remote active site.

    Evidence NMR relaxation and chemical-shift perturbation with enzyme kinetics, later supported by molecular dynamics

    PMID:25263960 PMID:27576863

    Open questions at the time
    • Allosteric coupling tested mainly on SUMO-1
    • Whether substrate identity tunes the allosteric response is unknown
  6. 2010 High

    Connected SENP1 to a hypoxia-responsive positive feedback loop by which HIF-1α transcribes SENP1 and SENP1 deSUMOylates/stabilizes HIF-1α, driving angiogenesis and later tumor stemness.

    Evidence ChIP, HRE promoter mutagenesis, siRNA, KO embryos, and xenografts across two studies

    PMID:20841360 PMID:28258134

    Open questions at the time
    • SUMOylation site on HIF-1α driving stabilization not fully mapped here
    • Loop kinetics in normal vs cancer tissue differ in unresolved ways
  7. 2010 High

    Identified GATA1 as a direct SENP1 substrate controlling erythropoiesis, with deSUMOylation restoring GATA1 DNA binding and transcription.

    Evidence SENP1 conditional KO mice, in vitro deSUMOylation, ChIP, and bone marrow transplant; extended to CMS iPSC erythroid cells

    PMID:20457756 PMID:27821551

    Open questions at the time
    • GATA1 SUMO site contribution to DNA binding mechanism partly inferred
    • Relative contributions of GATA1 vs Bcl-xL not fully separated
  8. 2008 High

    Established SENP1 as a redox- and cytokine-responsive enzyme that relocates from cytoplasm to nucleus, coupling stress signaling to deSUMOylation of nuclear substrates.

    Evidence Co-IP with thioredoxin, ROS-dependent release assays, catalytic mutant, siRNA, and KO MEFs

    PMID:18219322

    Open questions at the time
    • Did not define the redox-sensitive residue (later C535/C683)
    • Generality of thioredoxin complex across cell types untested
  9. 2013 High

    Showed SENP1 controls oncogenic protein stability and activity by deSUMOylating substrates such as Pin1 and c-Myc, the latter altering its ubiquitination and phosphorylation.

    Evidence In vitro deSUMOylation, SUMO-site mutagenesis, catalytic C603S mutant, Co-IP, and ubiquitination assays

    PMID:23633483 PMID:30305424

    Open questions at the time
    • Crosstalk hierarchy between deSUMOylation and ubiquitination not fully ordered
    • In vivo relevance of these axes in tumors not established here
  10. 2019 High

    Defined SENP1 as a metabolic-stress effector that translocates to mitochondria and activates Sirt3 by deSUMOylation, reprogramming mitochondrial acetylation across metabolism, T-cell memory, macrophage polarization, and kidney protection.

    Evidence In vitro deSUMOylation, SENP1 and Sirt3 KO/knock-in mice, mitochondrial fractionation, acetylation and metabolomic assays across multiple studies

    PMID:31302001 PMID:34272364 PMID:35417703 PMID:37608549

    Open questions at the time
    • The mitochondrial import mechanism of a nuclear protease is not molecularly defined
    • AMPK-to-SENP1 signaling link is correlative in places
  11. 2015 High

    Identified SENP1 as a redox-gated amplifier of insulin exocytosis and as a NEMO deSUMOylase restraining NF-κB inflammation, linking it to diabetes pathophysiology.

    Evidence Islet- and adipocyte-specific SENP1 KO mice, patch-clamp exocytosis, NEMO K277/309 mutagenesis, human T2D islet rescue

    PMID:26389676 PMID:26596471

    Open questions at the time
    • Distal exocytotic substrate(s) of SENP1 not molecularly identified
    • Tissue-of-origin for systemic phenotypes requires further dissection
  12. 2024 High

    Pinpointed the redox/metal chemistry that sets basal SENP1 activity, showing a C535 thiol with Zn2+ suppresses unrestrained exocytosis while reduced redox state activates it.

    Evidence C535 mutagenesis, β-cell- and pancreas-specific KO mice, patch-clamp, redox measurements, and glucose tolerance tests; complemented by C683 S-sulfhydration work

    PMID:36750014 PMID:38184650

    Open questions at the time
    • How redox state is sensed upstream of C535 in vivo is incomplete
    • Whether C535 and C683 act independently is unresolved
  13. 2023 High

    Revealed SENP1 as a regulator of SUMO-driven liquid-liquid phase separation, removing SUMO to prevent RNF168 and MAVS condensation, thereby tuning DNA repair and antiviral signaling.

    Evidence In vitro LLPS reconstitution, SIM-motif mutagenesis, ubiquitination assays, NHEJ reporters, and Co-IP

    PMID:37188808 PMID:37350666

    Open questions at the time
    • Generality of SENP1 control over phase separation across substrates unknown
    • Quantitative threshold of SUMO removal needed to dissolve condensates undefined
  14. 2021 High

    Linked SENP1 to a Mendelian neurodevelopmental disorder, showing a truncating mutation destabilizes FMRP and causes autistic-like deficits rescuable by region-specific SENP1 restoration.

    Evidence Human mutation identification, Senp1+/- mouse behavior and electrophysiology, FMRP SUMOylation/degradation assays, stereotaxic rescue

    PMID:34731627

    Open questions at the time
    • Single human proband limits genetic generalization
    • How FMRP SUMOylation triggers degradation mechanistically is partial

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how SENP1's broad substrate selectivity is achieved in vivo and how its nuclear, nuclear-pore, and mitochondrial localizations are coordinated across tissues and stress states.
  • No global rule governs which substrate is engaged in which compartment
  • The molecular machinery for nuclear-to-mitochondrial translocation is undefined
  • Substrate prioritization under competing stress signals is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 10 GO:0098772 molecular function regulator activity 4 GO:0140299 molecular sensor activity 3 GO:0016787 hydrolase activity 2
Localization
GO:0005739 mitochondrion 4 GO:0005634 nucleus 3 GO:0005829 cytosol 2
Pathway
R-HSA-168256 Immune System 6 R-HSA-1430728 Metabolism 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-8953897 Cellular responses to stimuli 4 R-HSA-162582 Signal Transduction 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-73894 DNA Repair 2 R-HSA-1640170 Cell Cycle 1
Partners
GATA1HIF-1ΑNEMONUP153RIPK1SIRT3SUMO1THIOREDOXIN
Complex memberships
TNF receptor signaling complex (TNF-RSC)nuclear pore complex

Evidence

Reading pass · 51 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 SENP1 is a nuclear-localized SUMO-specific cysteine protease; mutation of the N-terminal nuclear localization signal causes cytoplasmic accumulation; mutation of the active-site cysteine (dominant-negative) causes accumulation of high-molecular-weight SUMO-1 conjugates; the N-terminal regulatory domain suppresses constitutive catalytic activity of the core domain; SENP1 itself is a target for SUMO-1 modification at a nonconsensus site; SENP1 localization is influenced by SUMO-1-conjugated target proteins. Mutagenesis of NLS and catalytic cysteine, subcellular localization by imaging, immunoprecipitation, dominant-negative overexpression The Journal of biological chemistry High 14563852
2004 SENP1 enhances androgen receptor (AR)-dependent transcription not by deSUMOylating AR itself, but by deconjugating SUMO from HDAC1, thereby reducing HDAC1 deacetylase activity; RNAi depletion of HDAC1 reduced SENP1's transcriptional enhancement effect. Transcriptional reporter assays, RNAi knockdown of HDAC1, co-immunoprecipitation, in vitro deSUMOylation assay Molecular and cellular biology High 15199155
2005 SENP1 processes all SUMO-1, -2, and -3 precursors in vitro, with highest efficiency for SUMO-1 followed by SUMO-2 and SUMO-3; the catalytic domain alone determines substrate specificity; two residues immediately after the 'GG' region of SUMO precursors determine differential maturation efficiency. In vitro protease assay with purified recombinant SENP1, mutagenesis of SUMO precursor C-terminal fragments The Biochemical journal High 15487983
2005 Retroviral insertional mutation of mouse SENP1/SuPr-2 increases steady-state levels of sumoylated proteins and causes placental abnormalities and embryonic lethality, demonstrating that deSUMOylation by SENP1 is essential for mammalian development. Retroviral insertional mutagenesis in mice, Western blot for SUMO conjugates, embryonic phenotyping Molecular and cellular biology High 15923632
2005 SENP1 deSUMOylates HIPK2 both in vitro and in cells; SENP1 contains a nuclear export sequence (NES) in its C-terminal region and shuttles between cytoplasm and nucleus; forced nuclear localization of SENP1 or NES mutation enhances HIPK2 deSUMOylation and induces dissociation of HIPK2 from nuclear bodies. In vitro deSUMOylation assay, NES mutagenesis, co-immunoprecipitation, subcellular localization imaging FEBS letters Medium 16253240
2006 Crystal structure of SENP1 catalytic domain C603S mutant in complex with SUMO-1 at 2.8 Å resolution reveals that SENP1 requires a self-conformational change prior to peptide/isopeptide bond cleavage; four unique SENP1 residues facilitate SUMO-1 binding; SENP1 can also hydrolyze the thioester linkage in E1-SUMO and E2-SUMO intermediates. X-ray crystallography, in vitro protease activity assay with active-site mutant, structural comparison with SENP2 The Biochemical journal High 16712526
2008 In resting endothelial cells, SENP1 resides in the cytoplasm complexed with thioredoxin; TNF stimulation releases SENP1 from thioredoxin in a ROS-dependent manner and induces SENP1 nuclear translocation; nuclear SENP1 deSUMOylates HIPK1, promoting its cytoplasmic translocation and ASK1-JNK activation leading to apoptosis; catalytic-inactive SENP1 mutant and siRNA of SENP1 block this pathway. Co-immunoprecipitation, siRNA knockdown, catalytic mutant overexpression, SENP1-KO MEFs, subcellular fractionation/localization Cell death and differentiation High 18219322
2008 Among SENPs tested (1, 2, 3, 5, 6), only SENP1 and SENP2 efficiently cleave AR-SUMO-1 conjugates in intact cells and in vitro; androgens induce rapid SUMO-1 conjugation of AR; SENP1 reverses ligand-induced AR SUMOylation and promotes AR-dependent transcription in a catalytic activity-dependent and promoter-selective manner; SENP1 knockdown attenuates AR target gene expression and androgen-stimulated LNCaP cell growth. In vitro deSUMOylation assay, in-cell SUMOylation assay, siRNA knockdown, transcriptional reporter assay Molecular endocrinology High 19116244
2008 IL-6 induces SENP1 mRNA expression; SENP1 deSUMOylates PML, disrupting PML bodies and relieving PML-mediated suppression of STAT3 activation; catalytically inactive SENP1 fails to reverse PML suppression of STAT3. Co-immunoprecipitation, catalytic mutant, Western blot, STAT3 reporter assay Biochemical and biophysical research communications Medium 18474224
2010 SENP1 deSUMOylates GATA1 directly (demonstrated in vitro); SENP1 knockout mice develop anemia with fetal liver erythropoiesis defects; SUMOylated GATA1 accumulates in SENP1-KO livers and shows reduced DNA binding at GATA1-responsive gene promoters; GATA1-dependent gene expression and erythropoiesis are restored by SENP1-mediated deSUMOylation. SENP1 conditional knockout mice, in vitro deSUMOylation assay, bone marrow transplant, ChIP, Western blot The Journal of experimental medicine High 20457756
2010 HIF-1α is a direct transcriptional activator of SENP1 (via hypoxia response element on Senp1 promoter); SENP1 in turn deSUMOylates and stabilizes HIF-1α, forming a positive feedback loop; SENP1 silencing decreases VEGF production and endothelial cell angiogenic function; SENP1-null embryos show reduced vascular endothelial cells. ChIP, HRE promoter mutation, siRNA knockdown, angiogenesis assays, SENP1-KO embryo analysis The Journal of biological chemistry High 20841360
2010 SENP1 overexpression in rheumatoid arthritis synovial fibroblasts decreases histone H4 acetylation at the MMP-1 promoter, reduces MMP-1 expression and invasiveness; this effect is dependent on HDAC4 accumulation at the MMP-1 promoter; SENP1 fails to modulate MMP-1 in HDAC4-silenced cells. SENP1 overexpression, siRNA knockdown of HDAC4, ChIP, RT-PCR, invasion assay Journal of autoimmunity Medium 20079608
2010 SENP1 overexpression in prostate cancer promotes HIF-1α stabilization, VEGF production, and angiogenesis; androgen-driven SENP1 transgene in mice induces high-grade prostatic intraepithelial neoplasia; SENP1 also enhances AR- and cyclin D1-dependent prostate epithelial cell proliferation. Transgenic mouse model, immunohistochemistry, cell proliferation assays, VEGF measurement The Journal of biological chemistry Medium 20551310
2012 SENP1 and SENP2 are targeted to kinetochores in mitosis; SENP1 knockdown delays sister chromatid separation at metaphase; proper spatial and temporal control of sumoylation at kinetochores by SENP1 is required for chromosome segregation. siRNA knockdown, live-cell imaging, kinetochore targeting assays, chromosome segregation analysis Molecular biology of the cell Medium 24048451
2012 Nup153 interacts with SENP1 through its N-terminal domain; SENP1 and SENP2 co-depletion increases sumoylation of endogenous Nup153; SENP1 levels are influenced by Nup153 abundance (whereas SENP2 is not), suggesting Nup153 anchors SENP1 at the nuclear pore complex. Co-immunoprecipitation, RNAi depletion, dominant-negative mutants, Western blot for SUMO conjugates Nucleus Medium 22688647
2012 SENP1 and SENP2 co-depletion causes mislocalization and reduced levels of multiple nucleoporins, revealing a role for pore-associated SENPs in nucleoporin homeostasis and nuclear pore complex configuration; transport is altered under these conditions. siRNA co-depletion, immunofluorescence, transport kinetics assay Molecular biology of the cell Medium 24196834
2012 SENP1 deficiency increases ER stress-induced apoptosis by accumulating SUMOylated XBP1; SENP1 directly deSUMOylates XBP1 and increases its transcriptional activity; XBP1 target genes are downregulated in SENP1-KO cells under ER stress. SENP1-KO cells, in vitro deSUMOylation assay, transcriptional reporter assay, Western blot Cell cycle Medium 22370484
2013 SENP1 binds to and deSUMOylates Pin1 on Lys6 (WW domain) and Lys63 (PPIase domain); Pin1 SUMOylation inhibits its isomerase activity and oncogenic function; SENP1-mediated deSUMOylation promotes Pin1 oncogenic activity (centrosome amplification, cell transformation) and increases Pin1 protein stability. Co-immunoprecipitation, in vitro deSUMOylation assay, site-directed mutagenesis, cell transformation assay, centrosome amplification assay Cancer research High 23633483
2014 SENP1 regulates mitochondrial gene expression via deSUMOylation of MEF-2C, which enhances MEF-2C-mediated PGC-1α transcription; SENP1 expression in cardiomyocytes is induced by hypertrophic stimuli through calcium/calcineurin-NFAT3; genetic induction of SENP1 leads to mitochondrial dysregulation and cardiac dysfunction. Cardiomyocyte SENP1 transgenic mouse, co-immunoprecipitation, Western blot, gene expression analysis Journal of molecular and cellular cardiology Medium 25446185
2014 NMR relaxation measurements reveal that the β-grasp domain of SUMO-1 binding to SENP1's exosite induces structural changes ~20 Å away at the active site (including dynamics of 'lid' residue Trp465), allosterically activating the enzyme; this remote substrate-induced activation is required for efficient catalysis. NMR relaxation measurements, chemical shift perturbation, enzyme kinetic analysis Nature communications High 25263960
2015 SENP1 is required for amplification of glucose-stimulated insulin exocytosis in pancreatic β-cells; the ICDc pathway generates NADPH, leading to glutathione (GSH) reduction, which activates SENP1 to amplify exocytosis at the distal exocytotic site; islet-specific Senp1 deletion in mice causes impaired glucose tolerance by reducing this amplification; the pathway is impaired in human T2D and can be rescued by SENP1 pathway intermediates. Islet-specific Senp1 KO mice, patch-clamp exocytosis measurements, glucose tolerance test, introduction of signaling intermediates into human T2D islets The Journal of clinical investigation High 26389676
2015 Adipocyte-specific deletion of SENP1 enhances SUMOylation of NEMO (NF-κB essential molecule) at lysine 277/309, leading to increased NF-κB activity, proinflammatory cytokine production, pancreatic inflammation and type-1 diabetes-like phenotype; NF-κB inhibitors reverse β-cell damage and T1DM phenotype in SENP1-deficient mice. Adipocyte-specific SENP1-KO mice, Co-IP, site-directed mutagenesis of NEMO K277/309, NF-κB reporter, cytokine measurement Nature communications High 26596471
2016 Molecular dynamics simulations combined with the crystal structure show that SUMO1 β-grasp domain binding to the SENP1 exosite cleft allosterically activates SENP1 via a dock-and-coalesce mechanism: the β-grasp wedges open the exosite cleft, enabling docking of the SUMO C-terminus proximal portion, and strengthened cross-channel correlated motions allow the distal portion to coalesce at the catalytic center. Molecular dynamics simulation based on crystal structure, analysis of conformational and dynamic changes eLife Medium 27576863
2016 Senp1 drives hypoxia-induced erythrocytosis via GATA1 and Bcl-xL; altering SENP1 levels in CMS iPSC-derived erythroid cells converts the CMS erythropoietic phenotype to non-CMS and vice versa; GATA1 is an essential downstream target of SENP1 in this context. iPSC technology, lentiviral SENP1 manipulation, erythroid differentiation assays, Western blot The Journal of experimental medicine Medium 27821551
2017 SENP1 directly deSUMOylates HIF-1α, increasing its stability and transcriptional activity; HIF-1/2α directly transcribes SENP1 through hypoxia response elements; a positive feedback loop between SENP1 and HIF-1α drives hepatocellular carcinoma stemness under hypoxia. Immunoprecipitation for SUMO-HIF-1α, ChIP for HIF binding to SENP1 HRE, quantitative PCR, in vivo xenograft Gut High 28258134
2017 SENP1 deSUMOylates PTP1B; in SENP1-deficient macrophages, highly SUMOylated PTP1B fails to de-phosphorylate STAT3, leading to STAT3 activation which induces SOCS3 and suppresses STAT1 signaling; this SENP1→PTP1B→STAT3→SOCS3 axis negatively regulates IFN-γ-STAT1-mediated M1 macrophage activation. SENP1-KO macrophages, Co-IP/SUMOylation assays, phospho-STAT Western blot, Listeria infection assay Journal of molecular cell biology Medium 27702761
2017 SENP1-modulated sumoylation regulates RB and Lamin A/C interaction; SUMO1 conjugation of both RB and Lamin A/C is required for their interaction; SENP1 removes SUMO1 from both proteins; this SUMO1-dependent RB-Lamin A/C complex protects both proteins from proteasomal degradation. Co-immunoprecipitation, SUMO site mutagenesis, proteasome inhibitor experiments, Western blot Oncogene Medium 27270425
2017 SENP1 deSUMOylates PTEN; in the absence of SENP1, SUMO1-modified PTEN is sequestered in the cytosol where it binds to SUMOylated WWP2 (E3 ubiquitin ligase), promoting PTEN ubiquitylation and degradation; SENP1 thereby blocks SUMO1-dependent ubiquitylation of PTEN. Co-immunoprecipitation, SUMOylation assays, SENP1 transgenic and KO cells, subcellular fractionation Oncotarget Medium 27852060
2017 Hypoxia triggers SENP1-mediated deSUMOylation of KLF15 in pulmonary endothelial cells, causing KLF15 translocation from nucleus to cytoplasm; nuclear KLF15 normally represses Arg2 transcription; SENP1-mediated KLF15 deSUMOylation therefore de-represses Arg2 (arginase 2), contributing to endothelial dysfunction. Co-immunoprecipitation, subcellular fractionation, ChIP, SENP1 overexpression/knockdown, isolated pulmonary artery ring assay Arteriosclerosis, thrombosis, and vascular biology Medium 29472234
2017 Senp1 knockdown in nuclear pore complex (Nup153-depleted cells) displaces SENP1 from NPCs; artificial tethering of SENP1 to NPCs restores non-homologous end joining and 53BP1 sumoylation; proper NPC localization of SENP1 is required for 53BP1 SUMO1 modification and efficient NHEJ DNA repair. siRNA depletion, artificial tethering of SENP1 to NPC, NHEJ reporter assay, immunofluorescence, SUMO Western blot Journal of cell science Medium 28576968
2018 SENP1 interacts with and deSUMOylates c-Myc in cells and in vitro; overexpression of wild-type but not catalytically inactive C603S SENP1 stabilizes c-Myc; SENP1-mediated deSUMOylation reduces c-Myc polyubiquitination, inhibiting proteasomal degradation; deSUMOylation promotes monoubiquitinated c-Myc and phosphorylation at S62 and T58. Co-immunoprecipitation, in vitro deSUMOylation assay, catalytic mutant (C603S), siRNA knockdown, ubiquitination assay, Western blot Proceedings of the National Academy of Sciences of the United States of America High 30305424
2018 Streptonigrin binds SENP1 at the SUMO-binding surface, disrupting SENP1-SUMO1 interaction; NMR identified binding site with key aromatic π-stacking interactions; streptonigrin treatment increases global SUMOylation and reduces HIF-1α levels in cells. NMR chemical shift perturbation, site-directed mutagenesis, global SUMOylation assay, HIF-1α Western blot Biochemistry Medium 29481054
2019 SENP1 deSUMOylates Sirt3 in mitochondria; SUMOylation suppresses Sirt3 deacetylase activity; during fasting, SENP1 translocates into mitochondria and activates Sirt3 by deSUMOylation, leading to decreased acetylation of mitochondrial proteins and increased fatty acid oxidation; Sirt3 SUMOylation-deficient mutation reduces fat mass and antagonizes HFD-induced obesity. Co-immunoprecipitation, in vitro deSUMOylation assay, SENP1-KO mice, Sirt3 SUMOylation mutant knock-in mice, subcellular fractionation, metabolic phenotyping Molecular cell High 31302001
2019 SENP1 deSUMOylates USP28; SUMOylation of USP28 in normoxia suppresses its deubiquitinase activity towards HIF-1α; hypoxia activates SENP1-mediated USP28 deSUMOylation, enhancing USP28 activity to accumulate HIF-1α, forming a SENP1-USP28-HIF-1α positive feedback loop. Co-immunoprecipitation, GST pull-down, in vivo deSUMOylation assay, luciferase reporter, in vitro deubiquitinase assay Cancer cell international Medium 30622440
2019 SENP1 deSUMOylates JAK2; deSUMOylation of JAK2 leads to its cytoplasmic accumulation and activation; the RUNX2-driven SENP1/JAK2 axis mediates platinum resistance in ovarian cancer; SENP1 inhibition or deficiency overcomes platinum resistance. Co-immunoprecipitation, SUMOylation assay, subcellular fractionation, siRNA/shRNA knockdown, platinum resistance assays Cell death & disease Medium 33795649
2020 SENP1 deSUMOylates IDOL (E3 ubiquitin ligase) at K293; IDOL SUMOylation counteracts its autoubiquitination and elevates IDOL protein levels; SENP1 overexpression increases LDLR protein levels and LDL uptake by removing IDOL SUMOylation; loss of SENP1 lowers LDLR in an IDOL-dependent manner. Co-immunoprecipitation, SUMOylation assay, SENP1 overexpression/knockdown, LDL uptake assay, Western blot The Journal of biological chemistry Medium 33154164
2020 SENP1 deSUMOylates and stabilizes UBE2T; SENP1 knockout impairs HCC growth, migration and invasion; UBE2T overexpression or K8R (SUMOylation-deficient) mutation promotes cell growth and migration; the SENP1-UBE2T-Akt pathway mediates SENP1's carcinogenic activity. SENP1 KO cell model, Co-immunoprecipitation, deSUMOylation assay, UBE2T K8R mutagenesis, Akt signaling Western blot, in vivo xenograft Aging Medium 31969492
2021 Glucose limitation activates AMPK, which promotes SENP1-mediated Sirt3 deSUMOylation in T cell mitochondria; activated Sirt3 deacetylates mitochondrial metalloprotease YME1L1, suppressing its cleavage of OPA1 and facilitating mitochondrial fusion; this promotes T cell survival and memory development; fructose-1,6-bisphosphate (FBP) negatively regulates AMPK and suppresses the SENP1-Sirt3 axis. T cell-specific SENP1 and Sirt3 KO mice, co-immunoprecipitation, acetylation assays, mitochondrial morphology imaging, T cell memory assays Nature communications High 34272364
2021 SENP1 deSUMOylates RIPK1 within the TNF-R1 signaling complex (TNF-RSC); loss of SENP1 causes RIPK1 SUMOylation, re-orchestrates TNF-RSC, modulates RIPK1 ubiquitination patterns and activates RIPK1 kinase-dependent apoptosis; hepatocyte-specific SENP1-KO mice develop spontaneous NASH-related phenotypes reversed by RIPK1 kinase inhibition. Hepatocyte-specific SENP1-KO mice, Co-immunoprecipitation of TNF-RSC, RIPK1 SUMOylation/ubiquitination assays, genetic RIPK1 kinase inhibition rescue Nature communications High 36414671
2021 SENP1 promotes SENP1-Sirt3-GLUD1 axis in macrophages: SENP1 deSUMOylates Sirt3 to activate it; activated Sirt3 deacetylates GLUD1 (glutamate dehydrogenase 1), increasing its activity; increased GLUD1 activity promotes glutaminolysis and α-ketoglutarate accumulation, driving Jmjd3-dependent H3K27me3 demethylation and M2 macrophage polarization. SENP1-KO macrophages, co-immunoprecipitation, GLUD1 deacetylation assay, metabolomics, H3K27me3 ChIP Cell reports High 35417703
2021 De novo heterozygous truncating mutation of SENP1 causes autistic-like symptoms in humans and mice; Senp1+/- mice show social deficits and repetitive behaviors with impaired inhibitory/excitatory synaptic function in the retrosplenial agranular (RSA) cortex; loss of SENP1 increases SUMOylation and degradation of FMRP; re-introduction of SENP1 or FMRP in the RSA fully rescues synaptic and behavioral deficits. Human genetic mutation identification, Senp1+/- mice behavioral and electrophysiology assays, FMRP SUMOylation/degradation assay, stereotaxic virus rescue in RSA Cell reports High 34731627
2021 SENP1 deSUMOylates NEMO in microglia; overexpression of SENP1 inhibits IH-induced NEMO SUMOylation and NF-κB activation; SENP1-mediated NEMO deSUMOylation reduces neuroinflammation; siRNA-NEMO abolishes SENP1's protective effect, confirming NEMO as the relevant substrate. Co-immunoprecipitation, SUMOylation Western blot, siRNA epistasis for NEMO, NF-κB reporter assay Journal of cellular and molecular medicine Medium 34120412
2022 SENP1 deSUMOylates KLF4; the SENP1-KLF4 axis promotes M1 macrophage polarization through NF-κB signaling; KLF4 SUMOylation deficiency (mirroring SENP1 activity) weakens tumor cell activity in co-culture. Co-immunoprecipitation, KLF4 SUMOylation assay, NF-κB reporter, macrophage polarization assay The FEBS journal Medium 35942612
2023 SENP1 deSUMOylates RNF168; SUMOylated RNF168 undergoes liquid-liquid phase separation (LLPS), restricting its recruitment to DNA damage sites, reducing H2A ubiquitination, retaining 53BP1 in nuclear condensates, and impairing NHEJ; SENP1 prevents RNF168 LLPS by removing SUMO, promoting DNA repair and chemotherapy resistance. Co-immunoprecipitation, SUMOylation assay, in vitro LLPS assay, H2A ubiquitination assay, NHEJ reporter, siRNA/shRNA knockdown Cancer research High 37350666
2023 SENP1 deSUMOylates MAVS, inhibiting its PIAS3-induced poly-SUMOylation; poly-SUMOylation promotes K63-linked polyubiquitination and MAVS aggregation; SUMO conjugation enables MAVS phase separation through a newly identified SUMO-interacting motif (SIM) in MAVS; IRF3 is recruited to MAVS phase-separated droplets via a SIM in IRF3; IRF3 phosphorylation disables SIM-SUMO interactions, releasing activated IRF3. Co-immunoprecipitation, in vitro LLPS assay, ubiquitination assay, IRF3 phosphorylation assay, mutagenesis of MAVS/IRF3 SIM motifs Nature structural & molecular biology High 37188808
2023 SENP1 deSUMOylates RIPK1 to inhibit apoptosis; SENP1 deSUMOylates Sirt3 in mitochondria during ischemia; AMPK activation by metformin promotes SENP1-Sirt3 axis, decreasing mitochondrial SOD2 acetylation, reducing mtROS, and protecting against acute kidney injury. AKI mouse models, Sirt3 SUMOylation site mutant knock-in (Sirt3 KR) mice, AMPK activation by metformin, metabolomics, Western blot for acetylated SOD2, Co-IP Molecular therapy Medium 37608549
2023 H2S S-sulfhydrates SENP1 at C683, suppressing its protease activity; in diabetic cardiomyopathy, exogenous H2S S-sulfhydrates SENP1, increasing SERCA2a SUMOylation, improving SERCA2a expression and activity, calcium homeostasis and cardiomyocyte survival; SENP1 C683A mutant (non-sulfhydratable) abolishes these effects. SENP1 C683A mutagenesis, co-immunoprecipitation, SUMOylation assay, SERCA2a activity assay, calcium imaging, cardiac function measurement Biomedicine & pharmacotherapy Medium 36750014
2024 SENP1 redox sensing in β-cells requires a thiol group at C535 which, together with Zn2+-binding, suppresses basal protease activity and unrestrained exocytosis; a more reduced cytosolic redox state after high-fat diet increases β-cell exocytosis in a SENP1-dependent manner; pancreas- and β-cell-specific SENP1 KO mice fail to upregulate exocytosis and become rapidly glucose intolerant after 2-day HFD. C535 mutagenesis, β-cell-specific and pancreas-specific SENP1 KO mice, patch-clamp exocytosis, redox measurements, glucose tolerance test Nature communications High 38184650
2024 SENP1 deSUMOylates HDAC2; SENP1-mediated HDAC2 deSUMOylation enhances EGFR transcription and activates the AKT pathway in AML; IGF2BP3 binds the SENP1 3'-UTR in an m6A-dependent manner to upregulate SENP1 expression. Co-immunoprecipitation, SUMO assay, ChIP-qPCR, MERIP-qPCR, dual-luciferase reporter Molecular cancer Medium 38822351
2024 SENP1 deSUMOylates HSP90ab1 in cardiomyocytes; loss of SENP1 increases HSP90ab1 SUMOylation, leading to STAT3 activation and fibronectin secretion, which promotes fibroblast activation and cardiac fibrosis; mutation of HSP90ab1 Lys72 (SUMOylation site) or SENP1 overexpression ameliorates adverse ventricular remodeling after myocardial infarction. Cardiomyocyte-specific SENP1 KO and overexpression mice, Co-immunoprecipitation, HSP90ab1 K72 mutagenesis, cardiac function and fibrosis assessment Advanced science Medium 38992961
2024 SENP1 deSUMOylates ACSL4, reducing its protein stability via removal of SUMO1; SENP1 inhibition in HNSCC increases ACSL4 SUMOylation and stabilization, promoting ferroptosis; SENP1 also regulates GPX4 expression to control ferroptosis. Co-immunoprecipitation, Western blot for ACSL4 stability, ferroptosis assays (iron, MDA, GSH), shRNA knockdown Oncology reports Medium 38186303

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut 194 28258134
2019 SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Molecular cell 191 31302001
2015 Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. The Journal of clinical investigation 158 26389676
2004 SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Molecular and cellular biology 157 15199155
2003 Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. The Journal of biological chemistry 151 14563852
2021 Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nature communications 130 34272364
2022 SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization. Cell reports 104 35417703
2005 Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Molecular and cellular biology 90 15923632
2008 SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. Molecular endocrinology (Baltimore, Md.) 87 19116244
2010 SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. The Journal of biological chemistry 86 20551310
2023 SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer. Cancer research 81 37350666
2018 SUMO protease SENP1 deSUMOylates and stabilizes c-Myc. Proceedings of the National Academy of Sciences of the United States of America 78 30305424
2013 SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. Cancer research 78 23633483
2010 Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. The Journal of biological chemistry 76 20841360
2005 Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. The Biochemical journal 75 15487983
2010 SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. The Journal of experimental medicine 73 20457756
2014 SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway. Cardiovascular research 72 25082844
2011 Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 69 21989481
2010 Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression. Journal of autoimmunity 68 20079608
2022 SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation. Nature communications 64 36414671
2016 Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation. Oncotarget 64 27449295
2008 SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell death and differentiation 64 18219322
2008 Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging cell 58 18616636
2023 AMPK activation coupling SENP1-Sirt3 axis protects against acute kidney injury. Molecular therapy : the journal of the American Society of Gene Therapy 56 37608549
2015 SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nature communications 56 26596471
2006 Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease. The Biochemical journal 56 16712526
2015 Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells. Cancer science 48 25645686
2012 Chemotherapeutic sensitivity of testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4. Cancer research 48 23002208
2013 SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis. Molecular biology of the cell 46 24048451
2017 SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop. Journal of molecular cell biology 44 27702761
2024 N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2. Molecular cancer 43 38822351
2017 SENP1/HIF-1α feedback loop modulates hypoxia-induced cell proliferation, invasion, and EMT in human osteosarcoma cells. Journal of cellular biochemistry 43 28796315
2015 SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α. Scientific reports 43 26548925
2015 SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling. Biochemical and biophysical research communications 42 25791478
2023 MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation. Nature structural & molecular biology 41 37188808
2005 Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. FEBS letters 40 16253240
2021 Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation. International journal of medical sciences 39 33746578
2016 miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3. Cancer letters 39 27177472
2015 SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 38 26695141
2012 Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2. Nucleus (Austin, Tex.) 38 22688647
2017 SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget 37 27852060
2012 SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation. Cell cycle (Georgetown, Tex.) 37 22370484
2022 SENP1 inhibition suppresses the growth of lung cancer cells through activation of A20-mediated ferroptosis. Annals of translational medicine 36 35280420
2012 Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors. Bioorganic & medicinal chemistry letters 34 22801642
2021 SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance. Cell death & disease 33 33795649
2020 SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T. Aging 33 31969492
2016 Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells. Oncology reports 33 27573572
2022 SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization. The FEBS journal 31 35942612
2017 Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair. Journal of cell science 31 28576968
2016 Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. The Journal of experimental medicine 31 27821551
2013 Inhibition of SENP1 induces radiosensitization in lung cancer cells. Experimental and therapeutic medicine 31 24137315
2021 Long noncoding RNA MCM3AP-AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR-193a-5p/SENP1. Cancer medicine 30 33686713
2014 Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. Journal of molecular and cellular cardiology 30 25446185
2015 SENP1 regulates cell migration and invasion in neuroblastoma. Biotechnology and applied biochemistry 28 25816890
2021 SENP1 modulates microglia-mediated neuroinflammation toward intermittent hypoxia-induced cognitive decline through the de-SUMOylation of NEMO. Journal of cellular and molecular medicine 27 34120412
2024 Baicalin Attenuates Diabetic Cardiomyopathy In Vivo and In Vitro by Inhibiting Autophagy and Cell Death Through SENP1/SIRT3 Signaling Pathway Activation. Antioxidants & redox signaling 26 38687336
2018 Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium. Arteriosclerosis, thrombosis, and vascular biology 26 29472234
2021 Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. Free radical biology & medicine 25 34019931
2019 SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. Cancer cell international 25 30622440
2018 Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells. Biochemistry 25 29481054
2016 SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis. Oncotarget 25 27741516
2013 The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function. Molecular biology of the cell 25 24196834
2022 SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation. International journal of biological sciences 24 35342335
2022 Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis. Cancer gene therapy 24 36575317
2021 Role of the SENP1-SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury. Free radical biology & medicine 24 34311030
2005 Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Human molecular genetics 23 15917269
2022 SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling. Journal of the American Heart Association 21 36370010
2016 SENP1-modulated sumoylation regulates retinoblastoma protein (RB) and Lamin A/C interaction and stabilization. Oncogene 21 27270425
2016 Downregulation of SENP1 inhibits cell proliferation, migration and promotes apoptosis in human glioma cells. Oncology letters 21 27347128
2010 SENP1 participates in the dynamic regulation of Elk-1 SUMOylation. The Biochemical journal 21 20337593
2021 SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice. Cell reports 20 34731627
2020 SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1. The Journal of biological chemistry 20 33154164
2016 SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. Molecular medicine reports 20 26935971
2016 SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders. Experimental hematology 20 26952840
2008 The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. Biochemical and biophysical research communications 20 18474224
2024 METTL3-mediated m6A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I. Oncogene 19 38374407
2019 Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization. Journal of biomedical science 19 31629407
2023 SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway. International immunopharmacology 18 37137262
2021 SENP1 participates in Irinotecan resistance in human colon cancer cells. Journal of cellular biochemistry 18 34037277
2019 SENP1 Interacts with HIF1α to Regulate Glycolysis of Prostatic Carcinoma Cells. International journal of biological sciences 18 30745829
2019 SENP1-mediated NEMO de-SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro. Journal of cellular physiology 18 31549402
2016 Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism. eLife 18 27576863
2021 E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis. Gene therapy 17 34545207
2020 The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity. Journal of cellular biochemistry 17 32786121
2017 Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression. Cell & bioscience 17 28770041
2020 Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-κB interaction. American journal of translational research 16 33312380
2018 SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein. Heliyon 16 29862363
2024 SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1. Oncology reports 15 38186303
2024 SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 15 38992961
2023 Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 15 36750014
2022 Melatonin decreases androgen-sensitive prostate cancer growth by suppressing SENP1 expression. Translational andrology and urology 15 35242644
2021 Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition. Journal of biomolecular structure & dynamics 15 33533323
2024 A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature communications 14 38184650
2023 FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation. Cell biology international 14 37369969
2021 β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice. Diabetes 14 34462260
2016 Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer. Pathology oncology research : POR 14 27178176
2014 Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding. Nature communications 14 25263960
2012 Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells. Asian Pacific journal of cancer prevention : APJCP 14 22901169
2023 LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis. Pathology, research and practice 13 36827886
2019 CDX2/mir-145-5p/SENP1 Pathways Affect LNCaP Cells Invasion and Migration. Frontiers in oncology 13 31249806

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