Affinage

SENP1

Sentrin-specific protease 1 · UniProt Q9P0U3

Length
644 aa
Mass
73.5 kDa
Annotated
2026-04-28
100 papers in source corpus 48 papers cited in narrative 48 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SENP1 is a SUMO-specific cysteine protease that processes SUMO-1/-2/-3 precursors and deconjugates SUMO from a broad array of substrates, thereby controlling transcription, erythropoiesis, metabolism, DNA repair, immune signaling, and mitochondrial function. Its catalytic activity depends on C603 and is allosterically activated by the β-grasp domain of SUMO binding an exosite ~20 Å from the active site, with additional regulation by redox sensing at C535 in β-cells and S-sulfhydration at C683 (PMID:16712526, PMID:25263960, PMID:38184650, PMID:36750014). SENP1 shuttles between nucleus and cytoplasm via an N-terminal NLS and a C-terminal NES, localizes to kinetochores during mitosis, associates with the nuclear pore complex through Nup153, and translocates into mitochondria during fasting to activate Sirt3-dependent fatty acid oxidation and T cell memory formation (PMID:14563852, PMID:16253240, PMID:24048451, PMID:22688647, PMID:31302001, PMID:34272364). Mouse knockouts demonstrate that SENP1 is essential for embryonic development, definitive erythropoiesis through GATA1 deSUMOylation, incretin-stimulated insulin exocytosis in β-cells, and hepatocyte survival by restraining RIPK1-dependent apoptosis (PMID:15923632, PMID:20457756, PMID:26389676, PMID:34462260, PMID:36414671).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2003 High

    Establishing SENP1 as a catalytically active SUMO protease with regulated nuclear localization answered the basic question of how this protease is organized: it requires C603 for activity, contains an N-terminal NLS for nuclear targeting, and its N-terminus auto-inhibits the catalytic domain.

    Evidence NLS mutagenesis, catalytic-dead C→A mutant expression, immunofluorescence in mammalian cells

    PMID:14563852

    Open questions at the time
    • Structural basis of N-terminal autoinhibition not defined
    • Relative contributions of NLS vs. NES to steady-state localization not dissected
  2. 2004 High

    Demonstrating that SENP1 coactivates androgen receptor transcription indirectly—by deSUMOylating HDAC1 rather than AR itself—established the principle that SENP1 controls transcription through chromatin-modifying intermediates.

    Evidence Co-IP, transcriptional reporter assays, HDAC1 RNAi epistasis

    PMID:15199155

    Open questions at the time
    • Whether SENP1 can also directly deSUMOylate AR was unresolved at this stage
    • Identity of other HDAC family members regulated by SENP1 unknown
  3. 2005 High

    Biochemical reconstitution and mouse knockout together established that SENP1 processes all three SUMO paralog precursors with preference for SUMO-1, and that its loss causes embryonic lethality due to global SUMO hyperconjugation.

    Evidence In vitro protease assays with purified proteins and SUMO precursor mutagenesis; retroviral insertional KO mouse with placental defects

    PMID:15487983 PMID:15923632

    Open questions at the time
    • Specific substrates responsible for placental lethality not identified
    • Redundancy with other SENPs in vivo not quantified
  4. 2006 High

    The 2.8 Å crystal structure of SENP1 C603S–SUMO-1 revealed the active-site architecture, a required conformational change preceding cleavage, and four interface residues determining SUMO paralog specificity, providing the first structural framework for SENP1 catalysis.

    Evidence X-ray crystallography, in vitro maturation/deconjugation assays, active-site mutagenesis

    PMID:16712526

    Open questions at the time
    • Full-length structure including N-terminal regulatory domain unavailable
    • Structural basis for isopeptidase vs. endopeptidase preference not resolved
  5. 2008 High

    Discovery that TNF-induced ROS releases SENP1 from a cytoplasmic thioredoxin complex, triggering its nuclear translocation and HIPK1 deSUMOylation leading to ASK1-JNK-mediated apoptosis, established redox-regulated SENP1 shuttling as a signaling mechanism.

    Evidence In vitro deSUMOylation, reciprocal Co-IP for SENP1–thioredoxin, SENP1-KO MEFs, nuclear fractionation

    PMID:18219322

    Open questions at the time
    • Molecular detail of SENP1–thioredoxin interaction not structurally characterized
    • Whether other oxidative stimuli use the same release mechanism unknown
  6. 2010 High

    SENP1 knockout mice die of anemia due to impaired fetal liver erythropoiesis: SENP1 deSUMOylates GATA1 to restore its DNA-binding capacity at erythroid promoters, identifying the first essential developmental substrate axis for SENP1.

    Evidence Cre-loxP KO mice, bone marrow transplant, in vitro deSUMOylation, ChIP, flow cytometry

    PMID:20457756

    Open questions at the time
    • Whether GATA1 is the sole critical erythroid substrate not excluded
    • Post-natal erythropoietic role of SENP1 not addressed
  7. 2010 High

    Identification of a HIF-1α→SENP1→HIF-1α positive feedback loop—where HIF-1α transcriptionally induces SENP1, and SENP1 deSUMOylates and stabilizes HIF-1α—explained how hypoxic signaling is amplified in angiogenesis and later in cancer.

    Evidence ChIP for HIF-1α on SENP1 HRE, promoter mutagenesis, siRNA, SENP1-null embryo analysis; transgenic prostate model with IHC

    PMID:20551310 PMID:20841360

    Open questions at the time
    • How the loop is terminated or counter-regulated is unknown
    • Whether SENP1 deSUMOylates HIF-2α with equal efficiency not tested
  8. 2013 High

    SENP1 localizes to kinetochores during mitosis and its depletion delays sister chromatid separation, revealing a cell-cycle-specific function beyond interphase transcription regulation.

    Evidence RNAi, live-cell imaging, immunofluorescence, chromosome segregation assay

    PMID:24048451

    Open questions at the time
    • Kinetochore substrates of SENP1 not identified
    • Mechanism of SENP1 kinetochore recruitment unknown
  9. 2014 High

    NMR relaxation experiments revealed that the β-grasp domain of SUMO allosterically activates SENP1 by binding an exosite ~20 Å from the catalytic center, quenching nanosecond dynamics and restructuring the lid residue Trp465—providing a biophysical mechanism for substrate-assisted catalysis.

    Evidence NMR relaxation and chemical shift perturbation, enzyme kinetics; subsequent MD simulations describing 'dock-and-coalesce' mechanism

    PMID:25263960 PMID:27576863

    Open questions at the time
    • Whether allosteric activation differs for SUMO-2/3 vs. SUMO-1 not tested by NMR
    • Full kinetic model including N-terminal domain absent
  10. 2015 High

    Tissue-specific knockouts revealed that SENP1 controls insulin exocytosis in β-cells (via NADPH/GSH-dependent activation) and restrains NF-κB in adipocytes (by deSUMOylating NEMO at K277/K309), linking SENP1 to metabolic disease and diabetes.

    Evidence Islet-specific and adipocyte-specific KO mice, patch-clamp exocytosis, NF-κB reporter, metabolite supplementation, human T2D islets

    PMID:26389676 PMID:26596471

    Open questions at the time
    • Identity of β-cell exocytotic SUMO substrates not determined at this stage
    • Whether adipocyte NEMO is the sole relevant substrate for inflammatory phenotype unknown
  11. 2017 High

    Demonstration that SENP1 is tethered to the nuclear pore complex via Nup153 and that this localization is required for SUMO1-dependent 53BP1 recruitment to DNA double-strand breaks connected SENP1 to the DNA damage response pathway.

    Evidence Artificial tethering rescue of SENP1 at NPC in Nup153-depleted cells, DSB repair assay, 53BP1 SUMO modification assay

    PMID:28576968

    Open questions at the time
    • Whether SENP1 directly deSUMOylates 53BP1 or acts on an intermediate is unclear
    • Role of SENP1 in HR vs. NHEJ pathway choice not resolved
  12. 2018 High

    Showing that SENP1 deSUMOylates c-Myc to switch its ubiquitination pattern from poly- to mono-ubiquitination and stabilize the oncoprotein established SUMO-ubiquitin cross-talk as a key SENP1-regulated mechanism in oncogenesis.

    Evidence Co-IP, in vitro deSUMOylation, C603S catalytic mutant, ubiquitination assay

    PMID:30305424

    Open questions at the time
    • Which E3 ligase generates the SUMO-dependent polyubiquitin chain on c-Myc not identified
    • In vivo tumor model validation lacking
  13. 2019 High

    Discovery that SENP1 translocates into mitochondria during fasting to deSUMOylate Sirt3 and activate fatty acid oxidation expanded SENP1's functional compartment beyond the nucleus and identified a SENP1–Sirt3 metabolic axis.

    Evidence Mitochondrial fractionation, in vitro deSUMOylation, Sirt3 KR mutant, SENP1-KO mice, metabolic phenotyping

    PMID:31302001

    Open questions at the time
    • Mitochondrial import mechanism for SENP1 not characterized
    • Whether mitochondrial SENP1 has substrates beyond Sirt3 unknown
  14. 2021 High

    The SENP1–Sirt3 axis was extended to T cell immunology: SENP1 promotes T memory cell development by activating Sirt3-dependent OXPHOS and mitochondrial fusion through YME1L1 deacetylation, integrating metabolic and immune functions.

    Evidence T cell-specific KO, mitochondrial fractionation, acetylation assay, mitochondrial morphology imaging

    PMID:34272364

    Open questions at the time
    • Whether other immune cell lineages require SENP1–Sirt3 axis not tested
    • Upstream signals triggering mitochondrial SENP1 translocation in T cells not defined
  15. 2022 High

    Hepatocyte-specific SENP1 deletion showed that SENP1 restrains RIPK1-dependent apoptosis by deSUMOylating RIPK1 within the TNF receptor signaling complex, preventing NASH progression—the first link of SENP1 to death receptor complex regulation.

    Evidence Hepatocyte-specific KO, Co-IP of TNF-RSC, SUMOylation/ubiquitination assay, RIPK1 kinase inhibitor rescue

    PMID:36414671

    Open questions at the time
    • SUMOylation sites on RIPK1 not mapped
    • Whether SENP1 also regulates necroptosis through RIPK1/RIPK3/MLKL not tested
  16. 2023 High

    Two studies revealed that SENP1 counteracts SUMO-driven liquid-liquid phase separation: it prevents SUMOylated RNF168 from forming condensates that sequester it away from DNA damage sites, and it opposes PIAS3-mediated poly-SUMOylation of MAVS that drives MAVS aggregation for IRF3 recruitment during antiviral signaling.

    Evidence In vitro phase separation reconstitution for both RNF168 and MAVS, SIM mutagenesis, NHEJ repair and antiviral reporter assays

    PMID:37188808 PMID:37350666

    Open questions at the time
    • Whether SENP1 regulation of phase separation extends to other substrates is unknown
    • Kinetics of SENP1-mediated condensate dissolution not measured
  17. 2024 High

    Identification of C535 as a redox-sensing thiol in SENP1 that, together with Zn²⁺ binding, suppresses basal protease activity in β-cells provided the first molecular mechanism for how metabolic redox changes directly activate SENP1-dependent insulin exocytosis.

    Evidence C535 mutagenesis, redox manipulation, β-cell-specific KO, patch-clamp exocytosis, in vivo glucose tolerance

    PMID:38184650

    Open questions at the time
    • Whether C535 redox regulation operates in non-β-cell contexts unknown
    • Structural basis of Zn²⁺-mediated inhibition at C535 not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the mechanism of SENP1 mitochondrial import, whether allosteric activation differs among SUMO paralogs, the full-length structure including the N-terminal regulatory domain, and how SENP1 activity is terminated to prevent excessive deSUMOylation.
  • Full-length SENP1 structure unavailable
  • Mitochondrial targeting signal/import pathway not identified
  • Counter-regulatory mechanisms limiting SENP1 activity undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 11 GO:0016787 hydrolase activity 4
Localization
GO:0005634 nucleus 4 GO:0005635 nuclear envelope 3 GO:0005739 mitochondrion 2 GO:0005829 cytosol 2 GO:0005694 chromosome 1
Pathway
R-HSA-392499 Metabolism of proteins 10 R-HSA-162582 Signal Transduction 6 R-HSA-74160 Gene expression (Transcription) 6 R-HSA-168256 Immune System 5 R-HSA-1266738 Developmental Biology 3 R-HSA-1430728 Metabolism 3 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-73894 DNA Repair 2 R-HSA-1640170 Cell Cycle 1
Partners
GATA1HDAC1HIF1ANUP153RIPK1RNF168SIRT3SUMO1

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 SENP1 contains a nuclear localization signal in its N-terminus required for nuclear accumulation; mutation of this NLS causes cytoplasmic accumulation. The N-terminus also regulates protease activity, as expression of the core catalytic domain alone leads to constitutive activity. SENP1 is a cysteine protease (key catalytic cysteine required); a catalytic-dead mutant (C→A) acts as dominant negative, accumulating high-MW SUMO-1 conjugates. SENP1 itself can be SUMO-1 modified, and its localization is influenced by SUMO-1-conjugated target proteins. NLS mutation/cytoplasmic localization assay, dominant-negative catalytic mutant expression, immunofluorescence, co-localization The Journal of biological chemistry High 14563852
2004 SENP1 enhances androgen receptor (AR)-dependent transcription not by deSUMOylating AR itself, but by deSUMOylating HDAC1, thereby reducing HDAC1 deacetylase activity. RNAi depletion of HDAC1 reduces SENP1's transcriptional effect, placing HDAC1 deSUMOylation downstream of SENP1 in AR coactivation. Immunoprecipitation, transcriptional reporter assays, RNA interference, deSUMOylation assay Molecular and cellular biology High 15199155
2005 Purified SENP1 catalytic domain processes all three SUMO precursors (SUMO-1, -2, -3) in vitro; SUMO-1 is the preferred substrate. The C-terminal residues immediately after the 'GG' motif of SUMO precursors, including two specific residues, determine differential maturation efficiency. In vitro protease assay with purified recombinant proteins, mutagenesis of SUMO precursors The Biochemical journal High 15487983
2005 Mouse SENP1 knockout causes increased global SUMO conjugation and placental defects leading to embryonic lethality, establishing that SENP1-mediated deSUMOylation is essential for mammalian development. Retroviral insertional mutation/knockout mouse, western blot for SUMO conjugates, histology Molecular and cellular biology High 15923632
2005 SENP1 deSUMOylates HIPK2 both in vitro and in cells. SENP1 shuttles between cytoplasm and nucleus via a nuclear export sequence (NES) in its C-terminus; forced nuclear localization of SENP1 or NES mutation enhances HIPK2 deSUMOylation and dissociation of HIPK2 from nuclear bodies. In vitro deSUMOylation assay, NES mutant, co-immunoprecipitation, fluorescence microscopy FEBS letters High 16253240
2006 Crystal structure of SENP1 catalytic domain mutant C603S in complex with SUMO-1 resolved at 2.8 Å. The active-site cysteine (C603) is essential; C603S is catalytically inactive. Structure reveals a conformational change (self-conformational change) required prior to cleavage. Four unique SENP1 residues at the SUMO-1 interface determine substrate binding specificity. SENP1 can also hydrolyze the thioester linkage in E1-SUMO and E2-SUMO complexes. X-ray crystallography, in vitro maturation/deconjugation assay, active-site mutagenesis The Biochemical journal High 16712526
2008 SENP1 specifically deconjugates SUMO from HIPK1 in vitro and in vivo. In resting endothelial cells, SENP1 resides in the cytoplasm complexed with thioredoxin. TNF induces ROS-dependent release of SENP1 from thioredoxin and nuclear translocation of SENP1, correlating with HIPK1 deSUMOylation and cytoplasmic translocation of HIPK1, leading to ASK1-JNK activation and apoptosis. In vitro deSUMOylation assay, co-immunoprecipitation (SENP1-thioredoxin complex), siRNA knockdown, SENP1-KO MEFs, nuclear fractionation Cell death and differentiation High 18219322
2008 SENP1 (and SENP2) efficiently cleave AR-SUMO-1 conjugates in vitro and in intact cells; only agonist-bound AR is efficiently SUMOylated; SENP1 coactivating effect on AR transcription requires intact SUMO acceptor sites in AR and catalytic activity of SENP1, indicating direct deSUMOylation of AR mediates coactivation on compound ARE-containing promoters. In vitro deSUMOylation assay, reporter assay, siRNA, immunoprecipitation Molecular endocrinology High 19116244
2008 IL-6 induces SENP1 mRNA expression; SENP1 deSUMOylates PML, disrupting PML nuclear bodies; wild-type but not catalytically inactive SENP1 reverses PML-mediated suppression of STAT3 activation. RT-PCR, immunoprecipitation/co-immunoprecipitation, STAT3 reporter assay, catalytic mutant Biochemical and biophysical research communications Medium 18474224
2010 SENP1 knockout mice develop anemia and die between E13.5 and P1 due to erythropoiesis defects in fetal liver. SENP1 directly deSUMOylates GATA1 in vitro, and GATA1 SUMOylation reduces its DNA binding and recruitment to GATA1-responsive promoters, demonstrating SENP1 promotes GATA1-dependent erythropoiesis. Cre-loxP knockout mice, bone marrow transplant, in vitro deSUMOylation assay, ChIP, flow cytometry The Journal of experimental medicine High 20457756
2010 SENP1 is induced by hypoxia in endothelial cells via HIF-1α binding to an HRE on the SENP1 promoter (ChIP, HRE mutation). SENP1 knockdown reduces VEGF production and abrogates angiogenic function. SENP1-deficient mouse embryos show reduced endothelial cells in brain and kidney, establishing a HIF-1α→SENP1→VEGF positive feedback loop in angiogenesis. ChIP, HRE promoter mutagenesis, siRNA knockdown, SENP1-null mouse embryo analysis The Journal of biological chemistry High 20841360
2010 SENP1 overexpression in rheumatoid arthritis synovial fibroblasts decreases histone H4 acetylation at the MMP-1 promoter distal region and leads to accumulation of HDAC4 on that promoter. SENP1-mediated reduction of MMP-1 expression requires HDAC4; siRNA silencing of HDAC4 abolishes SENP1's effect on MMP-1. ChIP, HDAC4 siRNA epistasis, overexpression, invasion assay Journal of autoimmunity Medium 20079608
2010 SENP1 overexpression in a mouse prostate model stabilizes HIF-1α (by deSUMOylation), increases VEGF and angiogenesis, and promotes androgen receptor-dependent cell proliferation via cyclin D1, inducing high-grade prostatic intraepithelial neoplasia. Transgenic mouse model, immunoprecipitation, IHC, cell proliferation assays The Journal of biological chemistry High 20551310
2012 SENP1 deficiency promotes ER stress-induced apoptosis by increasing SUMOylation of the spliced XBP1 (XBP1s), reducing XBP1 target gene expression. SENP1 is identified as a specific deSUMOylating protease for XBP1. SENP1-KO cells, co-immunoprecipitation, transcriptional reporter, apoptosis assay Cell cycle Medium 22370484
2012 Nup153 binds SENP1 (and SENP2) at the nuclear pore complex via distinct sites in the N-terminal and C-terminal domains of Nup153. RNAi depletion or dominant-negative mutants of SENP1/SENP2 increase sumoylation of Nup153, identifying Nup153 as an endogenous SUMO substrate controlled by SENP1 at the NPC. Co-immunoprecipitation, RNAi, dominant-negative mutants, sumoylation assay Nucleus Medium 22688647
2013 SENP1 binds to and deSUMOylates Pin1 at K6 (WW domain) and K63 (PPIase domain). Pin1 SUMOylation inhibits its isomerase activity and oncogenic function; SENP1-mediated deSUMOylation restores Pin1 activity and promotes centrosome amplification and cell transformation. SENP1 also stabilizes Pin1 protein. Co-immunoprecipitation, in vitro deSUMOylation assay, site-directed mutagenesis, functional transformation assay Cancer research High 23633483
2013 SENP1 and SENP2 localize to kinetochores during mitosis. SENP1 knockdown delays sister chromatid separation at metaphase, while SENP2 knockdown produces no detectable phenotype. Altered SENP1 kinetochore association phenocopies SENP2 overexpression-induced chromosome congression defect, demonstrating SENP1 controls temporal deSUMOylation required for chromosome segregation. RNAi knockdown, live-cell imaging, immunofluorescence, chromosome segregation assay Molecular biology of the cell High 24048451
2013 SENP1 and SENP2 co-depletion causes mislocalization and reduced levels of multiple nucleoporins, revealing a role for pore-associated SENPs in nucleoporin homeostasis and NPC configuration. RNAi co-depletion, immunofluorescence, western blot, transport kinetics assay Molecular biology of the cell Medium 24196834
2014 NMR relaxation and chemical shift perturbation show that the β-grasp domain of SUMO1 binding to an exosite of SENP1 allosterically activates the protease by inducing structural changes ~20 Å away at the active site, including conformational changes involving the 'lid' residue Trp465 and quenching nanosecond dynamics. NMR relaxation measurements, chemical shift perturbation, enzyme kinetics Nature communications High 25263960
2014 SENP1 regulates mitochondrial biogenesis and cardiac function by deSUMOylating MEF-2C, enhancing MEF-2C-mediated PGC-1α transcription. Cardiac SENP1 expression is induced by hypertrophic stimuli via calcineurin-NFAT3 signaling. Genetic induction of SENP1 in cardiomyocytes leads to mitochondrial dysregulation and cardiac dysfunction. Transgenic mouse model, co-immunoprecipitation, ChIP, reporter assay Journal of molecular and cellular cardiology Medium 25446185
2014 SENP1 protects against myocardial ischemia/reperfusion injury via a HIF-1α-dependent pathway; SENP1+/- mice show larger infarct size and impaired systolic function after I/R; overexpression of HIF-1α reverses the effect of SENP1 knockdown. SENP1+/- mouse, coronary artery ligation, HIF-1α overexpression rescue, echocardiography Cardiovascular research Medium 25082844
2015 SENP1 deSUMOylates GATA1 to promote definitive erythropoiesis; islet-specific Senp1 deletion causes impaired glucose tolerance by reducing amplification of insulin exocytosis; the ICDc pathway generates NADPH/GSH which activates SENP1 to amplify insulin secretion at the distal exocytotic site. Islet-specific KO mice, patch-clamp exocytosis assay, metabolite supplementation, human islet studies The Journal of clinical investigation High 26389676
2015 Adipocyte-specific deletion of SENP1 leads to enhanced SUMOylation of NEMO (NF-κB essential modulator) at K277/K309, increasing NF-κB activity and proinflammatory cytokine production, causing pancreatic inflammation and type-1 diabetes-like phenotype. Adipocyte-specific conditional KO, co-immunoprecipitation for NEMO SUMOylation, NF-κB reporter, NF-κB inhibitor rescue Nature communications High 26596471
2016 SENP1 promotes HIF-1α stability by deSUMOylating HIF-1α; HIF-1α transcriptionally induces SENP1 expression via hypoxia response elements, forming a positive feedback loop. In HCC cells under hypoxia, this SENP1/HIF-1α loop enhances cancer stemness. Immunoprecipitation for HIF-1α SUMOylation, ChIP for HIF-1/2α on SENP1 HRE, shRNA knockdown, xenograft Gut High 28258134
2016 SENP1 deSUMOylates GATA1 and Bcl-xL in erythroid progenitors from chronic mountain sickness (CMS) subjects; manipulating SENP1 levels in iPSC-derived erythroid cells converts CMS to non-CMS erythropoietic phenotype and vice versa, with GATA1 identified as essential downstream target. iPSC technology, lentiviral SENP1 modulation, erythropoiesis assay, western blot The Journal of experimental medicine High 27821551
2016 Allosteric activation of SENP1 by the β-grasp domain of SUMO1 involves a 'dock-and-coalesce' mechanism: β-grasp domain wedges the exosite cleft, enabling docking of the SUMO C-terminus proximal portion and strengthening cross-channel motional coupling that allows the distal portion to coalesce around the catalytic center. Molecular dynamics simulation (validated against NMR data from prior structural work) eLife Medium 27576863
2016 SENP1 modulates sumoylation of RB and Lamin A/C; SUMO1 conjugation of both RB and Lamin A/C is required for their interaction; SENP1 deSUMOylation disrupts this complex; SUMO1-dependent RB-Lamin A/C complex protects both proteins from proteasomal degradation. Co-immunoprecipitation, proteasome inhibitor experiments, SUMO-site mutagenesis Oncogene Medium 27270425
2017 SENP1 deSUMOylates NEMO (via SENP1 de-SUMOylation of NEMO at K277/309) to regulate PTP1B SUMOylation status. In SENP1-deficient macrophages, SUMOylated PTP1B has reduced ability to de-phosphorylate STAT3, causing elevated STAT3 activity which suppresses STAT1 via SOCS3 induction, impairing IFN-γ/STAT1 signaling and M1 macrophage activation. SENP1-KO macrophages, co-immunoprecipitation, phospho-western, infection assay Journal of molecular cell biology Medium 27702761
2017 SENP1 localizes to the nuclear pore complex (NPC) via interaction with Nup153; tethering SENP1 to NPCs in Nup153-depleted cells restores SENP1-dependent SUMO1 modification of 53BP1, which is a prerequisite for efficient 53BP1 accumulation at DNA double-strand breaks and NHEJ repair. Artificial tethering of SENP1 to NPC, RNAi depletion, DSB repair assay, 53BP1 SUMO modification assay Journal of cell science High 28576968
2017 SENP1 participates in Elk-1 deSUMOylation; among SENPs, Elk-1 preferentially forms a complex with SENP1 (co-IP); SENP1 is the most efficient at promoting Elk-1 transactivation; SENP1 depletion reduces c-FOS target gene activation; SENP1 and SENP2 show partial redundancy in Elk-1 deSUMOylation. Co-immunoprecipitation, RNAi knockdown, combinatorial knockdown, reporter assay, ChIP The Biochemical journal Medium 20337593
2018 SENP1 interacts with and deSUMOylates c-Myc in cells and in vitro; wild-type but not catalytically inactive C603S SENP1 stabilizes c-Myc. SENP1-mediated deSUMOylation reduces c-Myc polyubiquitination and promotes monoubiquitinated c-Myc and its phosphorylation at S62/T58, indicating SUMOylation promotes c-Myc proteasomal degradation. Co-immunoprecipitation, in vitro deSUMOylation assay, catalytic mutant, ubiquitination assay Proceedings of the National Academy of Sciences of the United States of America High 30305424
2018 SENP1 deSUMOylates KLF15 under hypoxia, causing its translocation from nucleus to cytoplasm; nuclear KLF15 directly suppresses Arg2 (arginase 2) transcription in pulmonary endothelial cells; hypoxia-triggered KLF15 deSUMOylation by SENP1 releases Arg2 expression and impairs NO production. ChIP for KLF15 on Arg2 promoter, immunofluorescence for KLF15 localization, SENP1 overexpression, arginase activity assay Arteriosclerosis, thrombosis, and vascular biology Medium 29472234
2018 Streptonigrin binds SENP1 at the SUMO-binding surface (exosite), disrupting SENP1-SUMO1 interaction; NMR chemical shift perturbation identified key aromatic π-stacking residues involved in binding; cell treatment increases global SUMOylation and reduces HIF-1α levels. NMR chemical shift perturbation, site-directed mutagenesis, cell-based SUMOylation assay Biochemistry High 29481054
2019 Sirt3 is SUMOylated in mitochondria; SUMOylation suppresses Sirt3 deacetylase activity. During fasting, SENP1 translocates into mitochondria and deSUMOylates Sirt3, activating its deacetylase activity, leading to decreased mitochondrial protein acetylation and increased fatty acid oxidation. SENP1 deficiency causes hyper-SUMOylation of Sirt3, hyper-acetylation of mitochondrial proteins, and impaired metabolic adaptation. Co-immunoprecipitation, in vitro deSUMOylation assay, subcellular fractionation, SENP1-KO mice, Sirt3 KR mutation, metabolic phenotyping Molecular cell High 31302001
2019 SENP1 deSUMOylates USP28; under hypoxia, HIF-1α activates SENP1 which then deSUMOylates USP28, increasing USP28 deubiquitinase activity toward HIF-1α, amplifying HIF-1α accumulation in a positive feedback loop. Co-immunoprecipitation, GST pulldown, in vitro deSUMOylation assay, luciferase reporter Cancer cell international Medium 30622440
2020 SENP1 deSUMOylates IDOL (an E3 ubiquitin ligase for LDLR) at K293; SUMOylation of IDOL counteracts its auto-ubiquitination and increases IDOL stability. SENP1-mediated deSUMOylation reduces IDOL levels, increasing LDLR protein levels and LDL uptake; loss of SENP1 lowers LDLR in an IDOL-dependent manner. Co-immunoprecipitation, site-directed mutagenesis (K293), SENP1 KD, LDL uptake assay The Journal of biological chemistry High 33154164
2021 SENP1 promotes T cell memory development through Sirt3 deSUMOylation in mitochondria. SENP1-Sirt3 axis promotes OXPHOS and mitochondrial fusion by deacetylating mitochondrial metalloprotease YME1L1, suppressing OPA1 cleavage. Fructose-1,6-bisphosphate (FBP) negatively regulates AMPK-mediated SENP1-Sirt3 activation. T cell-specific KO, co-immunoprecipitation, mitochondrial fractionation, acetylation assay, mitochondrial morphology imaging Nature communications High 34272364
2021 SENP1 deficiency in neurons leads to increased SUMOylation and degradation of FMRP; re-introducing SENP1 or FMRP specifically in the retrosplenial agranular (RSA) cortex rescues synaptic function defects and autistic-like symptoms in Senp1+/- mice. Conditional heterozygous mice, stereotactic rescue (viral SENP1/FMRP expression), electrophysiology, behavioral tests Cell reports High 34731627
2021 β-cell SENP1 is required for incretin (GLP-1/GIP)-stimulated insulin exocytosis downstream of cAMP/Ca2+ signaling; β-cell-specific SENP1 KO mice develop oral glucose intolerance on HFD with impaired β-cell exocytosis to incretin receptor agonists without changes in cAMP or Ca2+ levels. β-cell-specific KO, patch-clamp exocytosis, insulin secretion assay, oral vs. IV glucose tolerance Diabetes High 34462260
2021 JAK2 is SUMOylated; SENP1 directly interacts with and deSUMOylates JAK2, causing JAK2 cytoplasmic accumulation and activation. This SENP1/JAK2 axis is activated in platinum-resistant ovarian cancer via RUNX2 transcription factor; SENP1 inhibition overcomes platinum resistance. Co-immunoprecipitation, subcellular fractionation, deSUMOylation assay, RUNX2 ChIP, drug resistance assay Cell death & disease Medium 33795649
2022 SENP1 deSUMOylates RIPK1 within the TNF receptor signaling complex (TNF-RSC), keeping RIPK1 kinase activity in check. SENP1 deficiency promotes RIPK1 SUMOylation, re-orchestrates TNF-RSC, and alters RIPK1 ubiquitination patterns to activate RIPK1-dependent apoptosis and NASH progression. Hepatocyte-specific SENP1-KO mice, Co-immunoprecipitation of TNF-RSC, SUMOylation/ubiquitination assay, RIPK1 kinase inhibitor rescue Nature communications High 36414671
2022 SENP1-Sirt3 signaling controls glutaminolysis for α-ketoglutarate (αKG) production during IL-4-stimulated M2 macrophage polarization. SENP1 deSUMOylates and activates Sirt3, which in turn deacetylates GLUD1 (glutamate dehydrogenase 1) to increase its activity, promoting αKG accumulation and Jmjd3-dependent H3K27me3 demethylation. Co-immunoprecipitation, deSUMOylation and deacetylation assays, GLUD1 activity assay, metabolomics Cell reports High 35417703
2022 SENP1 is identified as a specific deSUMOylase for KLF4; SENP1-KLF4 axis promotes M1 macrophage polarization by affecting NF-κB signaling; SUMOylation-deficient KLF4 macrophages exert anti-tumor activity. Co-immunoprecipitation, deSUMOylation assay, NF-κB reporter, macrophage polarization assay The FEBS journal Medium 35942612
2023 SUMOylated RNF168 undergoes liquid-liquid phase separation (LLPS), restricting its recruitment to DNA damage sites. SENP1 deSUMOylates RNF168, preventing LLPS and promoting RNF168 recruitment to DNA damage sites, RNF168-catalyzed H2A ubiquitination, and 53BP1-dependent NHEJ repair. Co-immunoprecipitation, in vitro phase separation assay, deSUMOylation assay, NHEJ repair assay, H2A ubiquitination assay Cancer research High 37350666
2023 SENP1 deSUMOylates MAVS; poly-SUMOylation of MAVS (mediated by PIAS3) promotes MAVS K63-linked polyubiquitination, aggregation, and liquid-liquid phase separation through a SUMO-interacting motif (SIM) in MAVS. IRF3 is recruited to SUMOylated MAVS droplets via a SIM in IRF3; IRF3 phosphorylation at residues adjacent to this SIM releases activated IRF3 from MAVS condensates. Co-immunoprecipitation, in vitro phase separation assay, SIM mutagenesis, IRF3 phosphorylation analysis, antiviral reporter assay Nature structural & molecular biology High 37188808
2023 Hydrogen sulfide (H2S) S-sulfhydrates SENP1 at C683, increasing its activity, which then deSUMOylates SERCA2a to increase its expression and activity, improving calcium homeostasis and cardiac function in diabetic cardiomyopathy. SENP1 C683A mutation blocks H2S-induced SERCA2a SUMOylation regulation. S-sulfhydration assay, co-immunoprecipitation, SENP1 C683A mutant, SERCA2a activity assay, in vivo diabetic model Biomedicine & pharmacotherapy Medium 36750014
2024 Redox sensing by SENP1 in β-cells is mediated by a thiol at C535; together with Zn2+-binding, C535 suppresses basal protease activity. A reduced cytosolic redox state (as occurs after 2-day high-fat diet) relieves this suppression and activates SENP1-dependent insulin exocytosis. Pancreas/β-cell-specific SENP1 KO mice fail to up-regulate exocytosis and become rapidly glucose intolerant. β-cell-specific KO, C535 mutagenesis, redox manipulation, patch-clamp exocytosis, in vivo glucose tolerance Nature communications High 38184650
2024 SENP1 deSUMOylates HSP90ab1 in cardiomyocytes; HSP90ab1 SUMOylation at K72 activates STAT3 and promotes fibronectin secretion, driving fibroblast activation and cardiac fibrosis after MI. SENP1 overexpression or HSP90ab1 K72 mutation ameliorates adverse ventricular remodeling. Cardiomyocyte-specific KO and overexpression mice, co-immunoprecipitation, K72 mutation, MI model, cardiac fibrosis assay Advanced science Medium 38992961

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut 191 28258134
2019 SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Molecular cell 189 31302001
2015 Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. The Journal of clinical investigation 156 26389676
2004 SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Molecular and cellular biology 156 15199155
2003 Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. The Journal of biological chemistry 151 14563852
2021 Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nature communications 124 34272364
2022 SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization. Cell reports 101 35417703
2005 Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Molecular and cellular biology 89 15923632
2008 SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. Molecular endocrinology (Baltimore, Md.) 87 19116244
2010 SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. The Journal of biological chemistry 86 20551310
2013 SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. Cancer research 78 23633483
2018 SUMO protease SENP1 deSUMOylates and stabilizes c-Myc. Proceedings of the National Academy of Sciences of the United States of America 77 30305424
2010 Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. The Journal of biological chemistry 76 20841360
2023 SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer. Cancer research 75 37350666
2005 Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. The Biochemical journal 75 15487983
2010 SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. The Journal of experimental medicine 72 20457756
2014 SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway. Cardiovascular research 71 25082844
2011 Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 68 21989481
2010 Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression. Journal of autoimmunity 68 20079608
2008 SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell death and differentiation 64 18219322
2016 Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation. Oncotarget 62 27449295
2022 SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation. Nature communications 58 36414671
2008 Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging cell 58 18616636
2006 Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease. The Biochemical journal 56 16712526
2015 SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nature communications 55 26596471
2023 AMPK activation coupling SENP1-Sirt3 axis protects against acute kidney injury. Molecular therapy : the journal of the American Society of Gene Therapy 52 37608549
2015 Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells. Cancer science 48 25645686
2012 Chemotherapeutic sensitivity of testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4. Cancer research 48 23002208
2013 SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis. Molecular biology of the cell 46 24048451
2017 SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop. Journal of molecular cell biology 43 27702761
2015 SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α. Scientific reports 43 26548925
2017 SENP1/HIF-1α feedback loop modulates hypoxia-induced cell proliferation, invasion, and EMT in human osteosarcoma cells. Journal of cellular biochemistry 42 28796315
2015 SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling. Biochemical and biophysical research communications 42 25791478
2005 Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. FEBS letters 40 16253240
2021 Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation. International journal of medical sciences 39 33746578
2016 miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3. Cancer letters 39 27177472
2012 Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2. Nucleus (Austin, Tex.) 38 22688647
2024 N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2. Molecular cancer 37 38822351
2023 MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation. Nature structural & molecular biology 37 37188808
2017 SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget 37 27852060
2012 SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation. Cell cycle (Georgetown, Tex.) 37 22370484
2015 SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 36 26695141
2022 SENP1 inhibition suppresses the growth of lung cancer cells through activation of A20-mediated ferroptosis. Annals of translational medicine 35 35280420
2012 Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors. Bioorganic & medicinal chemistry letters 34 22801642
2020 SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T. Aging 33 31969492
2016 Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells. Oncology reports 33 27573572
2022 SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization. The FEBS journal 31 35942612
2016 Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. The Journal of experimental medicine 31 27821551
2013 Inhibition of SENP1 induces radiosensitization in lung cancer cells. Experimental and therapeutic medicine 31 24137315
2021 Long noncoding RNA MCM3AP-AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR-193a-5p/SENP1. Cancer medicine 30 33686713
2017 Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair. Journal of cell science 30 28576968
2014 Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. Journal of molecular and cellular cardiology 30 25446185
2021 SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance. Cell death & disease 29 33795649
2015 SENP1 regulates cell migration and invasion in neuroblastoma. Biotechnology and applied biochemistry 28 25816890
2024 Baicalin Attenuates Diabetic Cardiomyopathy In Vivo and In Vitro by Inhibiting Autophagy and Cell Death Through SENP1/SIRT3 Signaling Pathway Activation. Antioxidants & redox signaling 26 38687336
2021 SENP1 modulates microglia-mediated neuroinflammation toward intermittent hypoxia-induced cognitive decline through the de-SUMOylation of NEMO. Journal of cellular and molecular medicine 26 34120412
2018 Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium. Arteriosclerosis, thrombosis, and vascular biology 26 29472234
2021 Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. Free radical biology & medicine 25 34019931
2019 SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. Cancer cell international 25 30622440
2018 Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells. Biochemistry 25 29481054
2016 SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis. Oncotarget 25 27741516
2013 The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function. Molecular biology of the cell 25 24196834
2022 Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis. Cancer gene therapy 24 36575317
2021 Role of the SENP1-SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury. Free radical biology & medicine 24 34311030
2005 Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Human molecular genetics 23 15917269
2022 SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation. International journal of biological sciences 21 35342335
2016 Downregulation of SENP1 inhibits cell proliferation, migration and promotes apoptosis in human glioma cells. Oncology letters 21 27347128
2010 SENP1 participates in the dynamic regulation of Elk-1 SUMOylation. The Biochemical journal 21 20337593
2021 SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice. Cell reports 20 34731627
2016 SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. Molecular medicine reports 20 26935971
2016 SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders. Experimental hematology 20 26952840
2016 SENP1-modulated sumoylation regulates retinoblastoma protein (RB) and Lamin A/C interaction and stabilization. Oncogene 20 27270425
2020 SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1. The Journal of biological chemistry 19 33154164
2019 Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization. Journal of biomedical science 19 31629407
2024 METTL3-mediated m6A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I. Oncogene 18 38374407
2023 SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway. International immunopharmacology 18 37137262
2022 SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling. Journal of the American Heart Association 18 36370010
2019 SENP1-mediated NEMO de-SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro. Journal of cellular physiology 18 31549402
2016 Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism. eLife 18 27576863
2008 The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. Biochemical and biophysical research communications 18 18474224
2021 SENP1 participates in Irinotecan resistance in human colon cancer cells. Journal of cellular biochemistry 17 34037277
2021 E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis. Gene therapy 17 34545207
2020 The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity. Journal of cellular biochemistry 17 32786121
2019 SENP1 Interacts with HIF1α to Regulate Glycolysis of Prostatic Carcinoma Cells. International journal of biological sciences 17 30745829
2017 Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression. Cell & bioscience 17 28770041
2018 SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein. Heliyon 16 29862363
2022 Melatonin decreases androgen-sensitive prostate cancer growth by suppressing SENP1 expression. Translational andrology and urology 15 35242644
2021 Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition. Journal of biomolecular structure & dynamics 15 33533323
2020 Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-κB interaction. American journal of translational research 15 33312380
2024 A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature communications 14 38184650
2024 SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1. Oncology reports 14 38186303
2024 SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 14 38992961
2023 Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 14 36750014
2023 FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation. Cell biology international 14 37369969
2021 β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice. Diabetes 14 34462260
2016 Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer. Pathology oncology research : POR 14 27178176
2014 Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding. Nature communications 14 25263960
2012 Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells. Asian Pacific journal of cancer prevention : APJCP 14 22901169
2023 LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis. Pathology, research and practice 13 36827886
2019 CDX2/mir-145-5p/SENP1 Pathways Affect LNCaP Cells Invasion and Migration. Frontiers in oncology 13 31249806