Affinage

SEMA3C

Semaphorin-3C · UniProt Q99985

Length
751 aa
Mass
85.2 kDa
Annotated
2026-06-10
36 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEMA3C is a secreted class-3 semaphorin that acts as an autocrine and paracrine ligand to guide neural development and to drive tumor growth, treatment resistance, and metastasis through neuropilin- and plexin-based receptor complexes (PMID:25464848, PMID:26053665, PMID:29348142). In development, neural-crest- and motoneuron-derived SEMA3C patterns axon navigation and motor nerve trajectories by tuning NRP1/NRP2 surface levels and receptor sensitivity (PMID:22899844), guides upper-layer cortical neuron migration under negative transcriptional control by Bcl11a (PMID:26182416), and activates NRP1 in outflow-tract endothelium to promote endothelial-to-mesenchymal transition required for cardiac septation (PMID:26053665). Its bioactivity depends on furin processing of the basic-domain cleavage site (742RNRR745), and a cleavage-resistant form acquires antiangiogenic activity that suppresses VEGF/PDGF-BB signaling (PMID:30304095, PMID:28036336). In cancer, SEMA3C signals through PlexinA2/D1 to activate Rac1/NF-κB and through PlexinB1 to transactivate the RTKs EGFR, ErbB2, and MET in a cognate-ligand-independent manner (PMID:25464848, PMID:29348142); it also drives Rac1-dependent β-catenin nuclear accumulation and ligand-independent Wnt target-gene transcription (PMID:37080989). Receptor usage is context-specific, with NRP2 and ITGB1 engaged to activate Hedgehog, MAPK, AKT/Gli1/c-Myc, and NF-κB programs across distinct tumor and stromal cell types (PMID:38956074, PMID:40402249, PMID:34742786). SEMA3C transcription is set by a dense network of regulators, repressed by Bcl11a and FOXA1 and activated by Foxc1/c2, FOXM1, MAOA-Twist1, and KLF6/FOSL2/p300-driven histone modification (PMID:26182416, PMID:38528115, PMID:28754980, PMID:34742786, PMID:33420365, PMID:40082673).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 2012 Medium

    Established that SEMA3C does not act as a simple repellent in isolation but tunes the cell's responsiveness to multiple Sema3 cues, answering how a single ligand specifies distinct motor axon trajectories.

    Evidence Gain- and loss-of-function by chick neural tube electroporation with in vivo spinal nerve positioning readouts

    PMID:22899844

    Open questions at the time
    • Molecular mechanism by which SEMA3C oppositely regulates Nrp1 vs Nrp2 surface levels not defined
    • Downstream signaling not dissected
  2. 2014 High

    Defined the first SEMA3C cancer signaling axis, showing autocrine/paracrine ligand engages PlexinA2/D1 to drive Rac1/NF-κB-dependent survival, with Rac1 placed causally downstream by rescue.

    Evidence Knockdown in orthotopic glioblastoma models with constitutively active Rac1 rescue and signaling assays

    PMID:25464848

    Open questions at the time
    • NF-κB target genes mediating survival not enumerated
    • Stoichiometry of PlexinA2/D1 receptor complex unresolved
  3. 2015 High

    Identified Bcl11a as a direct transcriptional repressor whose loss elevates SEMA3C to impair the multipolar-to-bipolar switch, linking SEMA3C dosage to cortical radial migration.

    Evidence Conditional knockout mouse with in vivo gain-of-function/rescue and ChIP promoter binding

    PMID:26182416

    Open questions at the time
    • Receptor mediating SEMA3C effect on migrating neurons not identified
    • Signaling downstream of elevated SEMA3C in this context unknown
  4. 2015 High

    Showed neural-crest SEMA3C activates NRP1 in outflow-tract endothelium to drive endothelial-to-mesenchymal transition, explaining its essential role in cardiac septal bridge formation.

    Evidence Ligand- and tissue-specific mouse mutants, explant assays, and lineage tracing

    PMID:26053665

    Open questions at the time
    • Plexin co-receptor for NRP1 in OFT endothelium not specified
    • Intracellular EndMT effectors not mapped
  5. 2017 Medium

    Placed SEMA3C in a cardiac transcriptional circuit, with Foxc1/c2 as direct activators and Fgf8/ERK1/2 as a repressive input that spatially restricts expression in migrating cardiac neural crest cells.

    Evidence TF binding/reporter assays, Tbx1 hypomorph mouse, and FGF8 blockade in chick with ERK1/2 readouts

    PMID:28754980

    Open questions at the time
    • Direct vs indirect effect of ERK1/2 on the Sema3C promoter not resolved
    • Single-lab epistasis
  6. 2018 High

    Revealed that SEMA3C transactivates EGFR, ErbB2, and MET through PlexinB1 independently of their cognate ligands, defining a druggable mechanism of treatment-resistant tumor growth.

    Evidence RTK phosphorylation assays, PlexinB1 knockdown/inhibition, LNCaP castration xenograft, and PlexinB1 sema-domain:Fc fusion treatment

    PMID:29348142

    Open questions at the time
    • Physical mode of PlexinB1-RTK coupling not structurally defined
    • Whether neuropilins participate in this complex unclear
  7. 2018 High

    Identified Ephrin-B1 as an Eph-receptor-independent silencer of SEMA3C/NRP1 signaling via direct N-glycosylation-dependent binding to NRP1, explaining loss of SEMA3C responsiveness in post-crossing callosal axons.

    Evidence Mouse genetics, N139 glycosylation-site mutagenesis, Co-IP, and axon guidance assays

    PMID:29779877

    Open questions at the time
    • How Ephrin-B1 binding occludes SEMA3C engagement of NRP1 mechanistically unresolved
    • Generality to other Sema3/NRP1 pairs untested here
  8. 2018 Medium

    Demonstrated that furin cleavage of the basic-domain site 742RNRR745 is required for SEMA3C antiangiogenic activity, defining processing as a determinant of functional output.

    Evidence Site-directed mutagenesis (R745A) with HUVEC tube-formation assay

    PMID:30304095

    Open questions at the time
    • Single in vitro readout
    • Receptor mediating antiangiogenic effect not identified
  9. 2016 Medium

    Showed a furin cleavage-resistant SEMA3C mutant inhibits VEGF and PDGF-BB signaling and suppresses neovascularization independently of VEGF binding, distinguishing processed from unprocessed forms functionally.

    Evidence Intravitreal FR-Sema3C injection in laser-induced CNV mouse, FITC-dextran imaging, endothelial RTK signaling assays

    PMID:28036336

    Open questions at the time
    • Receptor mediating FR-Sema3C inhibition of VEGF/PDGF signaling not defined
    • Relationship to furin-dependent activity in #10 not reconciled
  10. 2021 Medium

    Connected upstream MAOA-Twist1 transcriptional activation of SEMA3C to cMET-driven perineural invasion via PlexinA2/NRP1 co-receptors, extending the signaling axis to prostate cancer dissemination.

    Evidence Knockdown/overexpression in prostate cancer cells, orthotopic xenograft, perineural invasion assay, MAOA inhibition

    PMID:33420365

    Open questions at the time
    • Whether cMET activation here uses the PlexinB1 mechanism of #3 not addressed
    • Single lab
  11. 2021 Medium

    Identified FOXM1 as a direct promoter-binding activator of SEMA3C that engages NRP2 and Hedgehog signaling to drive M2 macrophage polarization, broadening SEMA3C to immune-stromal regulation.

    Evidence ChIP promoter binding, siRNA knockdown, macrophage overexpression, SMO inhibitor rescue

    PMID:34742786

    Open questions at the time
    • Direct vs indirect link between SEMA3C/NRP2 and Hedgehog activation unresolved
    • Single lab
  12. 2021 Medium

    Showed SEMA3C acts indirectly via Shh secretion to stimulate stromal androgen synthesis, establishing a paracrine non-cell-autonomous mode distinct from direct stromal action.

    Evidence Conditioned media transfer, LC-MS steroid quantification, steroidogenic enzyme qPCR, SMO antagonist treatment

    PMID:33503318

    Open questions at the time
    • Receptor on LNCaP cells transducing SEMA3C-driven Shh induction not identified
    • Recombinant SEMA3C alone inactive on stroma, mechanism of intermediary unclear
  13. 2023 High

    Established that SEMA3C drives ligand-independent Wnt signaling by Rac1-dependent β-catenin nuclear accumulation, and that combined SEMA3C/TCF1 targeting outperforms single-target therapy in glioblastoma.

    Evidence Wnt-ligand secretion suppression, β-catenin nuclear fractionation, Rac1 inhibition, TCF1 co-depletion in orthotopic GBM

    PMID:37080989

    Open questions at the time
    • Receptor linking SEMA3C to Rac1 in this Wnt context not specified
    • How Rac1 promotes β-catenin nuclear import mechanistically open
  14. 2024 Medium

    Defined FOXA1 as a negative regulator of SEMA3C through intronic cis elements, with forkhead-domain mutations relieving repression, linking recurrent prostate cancer FOXA1 mutations to SEMA3C upregulation.

    Evidence Reporter assays with FOXA1 mutants, ChIP, and analysis of FOXA1-mutant prostate specimens

    PMID:38528115

    Open questions at the time
    • Direct demonstration that mutants lose DNA binding inferred not shown
    • Single lab
  15. 2024 Medium

    Identified NRP1 and ITGB1 as functional SEMA3C receptors driving distinct programs in tumor versus stromal cells, with a TGF-β1/AP1 feedback loop reinforcing expression, depicting a self-sustaining tumor-microenvironment circuit.

    Evidence Co-IP/binding assays for NRP1/ITGB1, knockdown/overexpression, xenograft, pharmacological inhibition in HCC and hepatic stellate cells

    PMID:38956074

    Open questions at the time
    • Plexin partner of NRP1/ITGB1 complex not defined
    • Single lab
  16. 2024 Medium

    Showed P300-driven H3K27 acetylation activates SEMA3C transcription to promote β-catenin nuclear translocation and stemness in thyroid cancer, adding an epigenetic activating input upstream of Wnt.

    Evidence H3K27ac ChIP, P300 overexpression, DKK1 inhibition, β-catenin nuclear fractionation

    PMID:39667698

    Open questions at the time
    • Receptor transducing SEMA3C to β-catenin in thyroid cells not identified
    • Single lab
  17. 2025 Medium

    Showed CAF-secreted SEMA3C engages NRP2 to activate MAPK in colorectal liver metastasis-initiating cells, defining a stromal-to-tumor paracrine driver of organ-specific metastasis.

    Evidence In vivo and in vitro SEMA3C-NRP2 receptor-ligand experiments with MAPK activation readouts

    PMID:40402249

    Open questions at the time
    • Plexin co-receptor with NRP2 not defined
    • Single lab
  18. 2025 Medium

    Established a chromatin mechanism in which KLF6 recruits PCAF-p300/CBP and cooperates with FOSL2 to deposit H3K23 succinylation activating SEMA3C and downstream Wnt, linking metabolic histone modification to 5-FU resistance.

    Evidence CUT&Tag, ATAC-seq, RNA-seq, ChIP for KLF6/FOSL2, luciferase reporters in 5-FU-resistant colon cancer

    PMID:40082673

    Open questions at the time
    • Causality of H3K23 succinylation vs acetylation in SEMA3C activation not fully separated
    • Single lab
  19. 2025 Medium

    Implicated astrocyte-derived SEMA3C in restraining dendrite outgrowth via PLXND1 and NRP2, with its genetic reduction rescuing dendritic, synaptic, and behavioral deficits in a Rett syndrome model.

    Evidence Astrocyte-neuron co-culture, PLXND1/NRP2 blocking, conditional astrocyte SEMA3C reduction in RTT mice, electrophysiology and behavior (preprint)

    PMID:41279175

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Intracellular pathway downstream of PLXND1/NRP2 in dendrites not mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SEMA3C selects among its many receptor combinations (NRP1, NRP2, PlexinA2/D1, PlexinB1, PLXND1, ITGB1) to channel into distinct effector pathways in a given cell type remains unresolved.
  • No structural model of context-specific receptor complex assembly
  • Rules governing pathway choice (Rac1/NF-κB vs RTK vs Wnt vs MAPK vs Hedgehog) undefined
  • Role of furin processing in receptor selectivity not integrated across studies

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 5 GO:0060089 molecular transducer activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 4
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4 R-HSA-112316 Neuronal System 3 R-HSA-1266738 Developmental Biology 3
Partners
EFNB1ITGB1NRP1NRP2PLXNA2PLXNB1PLXND1

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 GSCs preferentially secrete Sema3C and coordinately express PlexinA2/D1 receptors to activate Rac1/NF-κB signaling in an autocrine/paracrine loop to promote GSC survival; introduction of activated Rac1 rescued the Sema3C knockdown phenotype in vivo, placing Rac1 downstream of Sema3C/PlexinA2/D1. Knockdown in orthotopic glioblastoma models, rescue with constitutively active Rac1, signaling assays Cell reports High 25464848
2015 Transcription factor Bcl11a directly and negatively regulates Sema3C transcription; in Bcl11a-deficient neurons, elevated Sema3C expression impairs the multipolar-to-bipolar switch and radial migration of upper-layer cortical neurons; gain-of-function and rescue experiments confirmed Sema3C as a major downstream effector of Bcl11a in cortical migration. Conditional knockout mouse, in vivo gain-of-function and rescue experiments, ChIP/promoter binding assays Neuron High 26182416
2021 MAOA activates SEMA3C transcription via Twist1; SEMA3C in turn stimulates cMET to facilitate prostate cancer perineural invasion via autocrine/paracrine signaling through co-activated PlexinA2 and NRP1 co-receptors. Knockdown/overexpression in prostate cancer cells, orthotopic xenograft model, in vitro perineural invasion assay, MAOA inhibitor treatment Oncogene Medium 33420365
2018 SEMA3C drives activation of multiple RTKs including EGFR, ErbB2, and MET in a cognate-ligand-independent manner via Plexin B1; Plexin B1 sema-domain:Fc fusion proteins suppress this RTK signaling and cell growth. RTK phosphorylation assays, PlexinB1 knockdown/inhibition, LNCaP xenograft castration model, Fc fusion protein treatment EMBO molecular medicine High 29348142
2015 Neural crest-derived SEMA3C activates NRP1 in the outflow tract endothelium to promote endothelial-to-mesenchymal transition, supplying cells to endocardial cushions and repositioning cardiac neural crest cells, which are essential for OFT septal bridge formation. Ligand-specific and tissue-specific mouse mutants, explant assays, gene-expression studies, lineage tracing The Journal of clinical investigation High 26053665
2017 Foxc1/c2 directly activates Sema3C transcription in the cardiac outflow tract; Fgf8 (downstream of Tbx1 in the second heart field) inhibits Sema3C expression in cardiac neural crest cells via ERK1/2 activation; blocking FGF8 causes ectopic SEMA3C expression and migration defects of cNCCs. Transcription factor binding/reporter assays, Tbx1 hypomorph mouse, FGF8 blocking experiments in chick, ERK1/2 signaling assays Scientific reports Medium 28754980
2021 FOXM1 binds to the promoter region of SEMA3C to elevate its expression; SEMA3C upregulates NRP2 and activates the Hedgehog signaling pathway; silencing SMO (Hedgehog transducer) negated the promoting effect of FOXM1 overexpression on M2 macrophage polarization. ChIP/promoter binding assay, siRNA knockdown, overexpression in macrophages, SMO inhibitor treatment Diabetes research and clinical practice Medium 34742786
2019 In corneal epithelial cells, SEMA3C signals through NRP2 (not NRP1) to promote epithelial wound closure and sensory nerve regeneration; siRNA knockdown of SEMA3C or NRP2-neutralizing antibodies decreased wound healing and nerve regeneration, whereas exogenous SEMA3C rescued these deficits in diabetic corneas. siRNA injection in vivo, neutralizing antibody treatment, exogenous recombinant SEMA3C injection, corneal wound healing and reinnervation readouts Diabetes Medium 30679185
2018 Post-crossing corpus callosum axons upregulate Ephrin-B1, which inhibits Sema3C/NRP1 signaling through direct interaction between Ephrin-B1 and Nrp1; this silencing is independent of Eph receptors and requires the N-glycosylation site N-139 in the extracellular domain of Ephrin-B1. In vivo mouse genetics, N-glycosylation site mutagenesis, co-immunoprecipitation, axon guidance assays Current biology : CB High 29779877
2012 Motoneuronal Sema3C regulates the surface levels of shared Sema3 neuropilin receptors Nrp1 and Nrp2 in opposite directions at the growth cone, thereby setting population-specific axon sensitivity to limb-derived Sema3A, Sema3F, and Sema3C repellents and specifying stereotyped motor nerve trajectories. Targeted gain- and loss-of-function in chick neural tube (electroporation), in vivo analysis of spinal nerve positioning Development (Cambridge, England) Medium 22899844
2018 The furin cleavage site 742RNRR745 in the basic domain of Sema3C is essential for its antiangiogenic activity; point mutation R745A abrogated the inhibitory effect of Sema3C on microcapillary formation by HUVECs in vitro. Site-directed mutagenesis of furin recognition site, in vitro angiogenesis (HUVEC tube formation) assay Brazilian journal of medical and biological research Medium 30304095
2016 FR-Sema3C (a furin cleavage-resistant mutant) inhibits VEGF and PDGF-BB signal transduction in endothelial cells and suppresses choroidal neovascularization in a laser-induced CNV mouse model independently of VEGF binding. Intravitreal injection in mouse CNV model, FITC-dextran vascular imaging, RTK signaling assays in endothelial cells PloS one Medium 28036336
2023 Sema3C directs β-catenin nuclear accumulation in a Rac1-dependent manner, leading to transactivation of Wnt target genes independently of Wnt ligand secretion; combined depletion of Sema3C and TCF1 extended survival in mouse glioblastoma model more than single-target inhibition. Wnt ligand secretion suppression, β-catenin nuclear fractionation, Rac1 inhibition, TCF1 co-depletion in orthotopic mouse GBM model Nature communications High 37080989
2024 SEMA3C binds NRP1 and ITGB1 as functional receptors in both HCC cells and hepatic stellate cells (HSCs); in HCC cells this activates AKT/Gli1/c-Myc signaling to bolster self-renewal; in HSCs it activates NF-κB signaling, stimulating IL-6 release and HMGCR-dependent cholesterol synthesis; CAF-secreted TGF-β1 activates AP1 to augment SEMA3C expression in HCC cells, establishing a positive feedback loop. Co-immunoprecipitation/binding assays for NRP1/ITGB1, knockdown/overexpression, in vivo xenograft, pharmacological inhibition Signal transduction and targeted therapy Medium 38956074
2025 CAF-secreted SEMA3C binds to NRP2 receptor on colorectal cancer liver metastasis-initiating cells, activating the MAPK pathway to promote liver metastasis. In vivo and in vitro experiments with SEMA3C-NRP2 receptor-ligand pair, MAPK pathway activation assays Proceedings of the National Academy of Sciences of the United States of America Medium 40402249
2024 FOXA1 negatively regulates SEMA3C via intronic cis elements; mutations in the FOXA1 forkhead domain attenuate its inhibitory function in reporter assays, presumably by disrupting FOXA1 DNA binding, leading to elevated SEMA3C expression. Reporter assays, ChIP, analysis of prostate cancer specimens with FOXA1 mutations Scientific reports Medium 38528115
2025 KLF6 recruits the PCAF-p300/CBP complex to the SEMA3C promoter; together with FOSL2, this synergistically increases H3K23 succinylation and promotes SEMA3C transcription, which activates canonical Wnt-β-catenin signaling leading to upregulation of MYC and FOSL2 in 5-FU-resistant colon cancer cells. CUT&Tag, ATAC-seq, RNA-seq, chromatin immunoprecipitation (ChIP) for KLF6/FOSL2 binding, luciferase reporter assays Experimental & molecular medicine Medium 40082673
2024 P300 (EP300) increases H3K27 acetylation at the SEMA3C locus to promote its transcriptional activation in thyroid cancer; overexpressed SEMA3C enhances β-catenin nuclear translocation; DKK1 (Wnt inhibitor) offsets the pro-migratory and pro-stemness effects of SEMA3C overexpression. ChIP for H3K27ac, P300 overexpression, DKK1 pharmacological inhibition, β-catenin nuclear fractionation Experimental cell research Medium 39667698
2021 SEMA3C overexpression in LNCaP cells upregulates Sonic Hedgehog (Shh) secretion, which in turn stimulates steroidogenic enzyme expression and androgen synthesis in prostatic stromal cells via the Shh pathway; blockade of Shh signaling with a smoothened antagonist abolished the effect. Notably, recombinant SEMA3C protein alone had no direct effect on steroidogenic activities in stromal cells. Conditioned media transfer, LC-MS steroid quantification, qPCR for steroidogenic enzymes, SMO antagonist treatment The Prostate Medium 33503318
2025 SEMA3C inhibits cortical neuron dendrite outgrowth via PLXND1 and NRP2 receptors; genetic reduction of astrocyte-derived SEMA3C in RTT model mice enhances dendritic arborization, normalizes synaptic activity, and improves visual acuity and motor behavior. Astrocyte-neuron co-culture, PLXND1/NRP2 receptor blocking, conditional astrocyte-specific SEMA3C reduction in RTT mice, dendritic morphology, electrophysiology, behavioral assays bioRxiv : the preprint server for biologypreprint Medium 41279175

Source papers

Stage 0 corpus · 36 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation. Cell reports 99 25464848
2015 Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c. Neuron 89 26182416
2021 MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling. Oncogene 76 33420365
2018 SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1. EMBO molecular medicine 68 29348142
2015 Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation. The Journal of clinical investigation 60 26053665
2024 Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression. Signal transduction and targeted therapy 50 38956074
2017 Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development. Scientific reports 46 28754980
2021 FOXM1 accelerates wound healing in diabetic foot ulcer by inducing M2 macrophage polarization through a mechanism involving SEMA3C/NRP2/Hedgehog signaling. Diabetes research and clinical practice 39 34742786
2019 Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. Diabetes 36 30679185
2018 Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons. Current biology : CB 31 29779877
2012 Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins. Development (Cambridge, England) 28 22899844
2021 LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. Nature communications 27 33568674
2023 Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma. Nature communications 25 37080989
2022 SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment. Frontiers in oncology 24 35785187
2015 High level of Sema3C is associated with glioma malignancy. Diagnostic pathology 22 26032848
2019 The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model. International journal of molecular sciences 17 31726800
2007 Selenium modification of nucleic acids: preparation of oligonucleotides with incorporated 2'-SeMe-uridine for crystallographic phasing of nucleic acid structures. Nature protocols 16 17406626
2025 KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells. Experimental & molecular medicine 13 40082673
2018 Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 11 30304095
2025 Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation. Proceedings of the National Academy of Sciences of the United States of America 10 40402249
2016 A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization. PloS one 9 28036336
2019 Effects of Notch signalling on the expression of SEMA3C, HMGA2, CXCL14, CXCR7, and CCL20 in breast cancer. Turkish journal of biology = Turk biyoloji dergisi 7 30930637
2023 Dependency of Tamoxifen Sensitive and Resistant ER+ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth. Cells 6 37443749
2021 Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family. Human genetics 6 34076780
2020 Spatial association of SEMA3C with nerve endings/terminal Schwann cells in hair follicle isthmus region. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 5 32954569
2024 Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer. Scientific reports 4 38528115
2012 The karyomastigont as an evolutionary seme. The Quarterly review of biology 4 23397796
2024 SEMA3C promotes thyroid cancer via the Wnt/β-catenin pathway. Experimental cell research 3 39667698
2021 SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling. The Prostate 3 33503318
2026 Tumor-stroma contributes to immunotherapeutic resistance in non-small cell lung cancer via SEMA3C-mediated immunosuppressive tumor microenvironment. Translational oncology 1 41558146
2025 The novel protein SEMA3C-319aa triggers glutathione metabolism-dependent ferroptosis in gastric cancer. Oncogene 1 40954198
2026 Silencing MALAT1 represses pathological progression, inflammation, and vascular smooth muscle cell phenotype switching by regulating the SEMA3C-mediated Smad pathway in intracranial aneurysms. Frontiers in cellular neuroscience 0 41890214
2026 A LINE-1 retrotransposon promotes SEMA3C expression as a cis-regulatory enhancer to sustain breast cancer stem cell survival. Science China. Life sciences 0 41984404
2025 SEMA3C regulates tumor-associated macrophage phenotype and influences lung cancer cell migration and invasion through VNN1. Human & experimental toxicology 0 40901786
2025 Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes. bioRxiv : the preprint server for biology 0 41279175
2024 A Pilot Study of the Role of Semaphorin 4A (sema4A) and 3C (sema3C) in Non-Muscle-Invasive Bladder Cancer (NMIBC). Biomedicines 0 39457718

Missed literature

Know a paper Affinage missed for SEMA3C? Flag it for the maintainers and the community.

No submissions yet.