Affinage

NRP2

Protein kinase C-binding protein NELL2 · UniProt Q99435

Length
816 aa
Mass
91.3 kDa
Annotated
2026-06-13
66 papers in source corpus 25 papers cited in narrative 27 extracted findings
Cross-family judge vs UniProt: Affinage preferred

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NRP2 is a pleiotropic transmembrane co-receptor that transduces class 3 semaphorin and VEGF-family cues to guide neuronal circuit formation, vascular biology, and immune regulation (PMID:22790009, PMID:28731029). In the nervous system, NRP2 binds SEMA3F and, cooperating with NRP1, controls sympathetic gangliogenesis and neurite targeting (PMID:22790009), and in mitral cells directs migration and axonal projection that underlie odour-driven social behaviour (PMID:28731029); semaphorin signalling is read out through NRP2/PlexinA1 receptor complexes, which can be engineered with a bispecific antibody to mimic SEMA3F-induced dimerization, suppress phospho-AKT, and restrain proliferation (PMID:41391772, PMID:36720439). In endothelium NRP2 stabilizes adherens junctions by promoting VE-cadherin/p120-catenin interaction, and it governs cell migration and adhesion through Rac-1-dependent control of ITGA5 integrin recycling and through SSH1/cofilin-driven F-actin polymerization (PMID:32528960, PMID:32983407). NRP2 also forms a VEGF-C complex under disturbed flow and modulates apoptosis via PARP1, linking it to endothelial inflammation and atherosclerosis (PMID:35028975, PMID:36764279). As an immune receptor, NRP2 acts as a co-inhibitory receptor on effector CD4+ T cells, binds the HARSWHEP histidyl-tRNA synthetase splice variant and the CD3L1/ITPRIPL1 ligand on macrophages to suppress inflammation and drive immunosuppressive M2 polarization, and on alveolar macrophages physically engages neutrophils to promote bacterial clearance (PMID:40073151, PMID:42141271, PMID:35435271). Across cancers NRP2 acts downstream of TGFβ/SMAD2 and MUC16-JAK2/STAT1 inputs to promote EMT, migration, and metastasis, and activates focal adhesion signalling via direct FAK binding (PMID:32038994, PMID:35533267, PMID:36306654, PMID:41861662). NRP2 additionally serves as a host entry receptor for Lujo virus through its N-terminal domain and for the cytomegalovirus pentamer complex (PMID:29120745, PMID:41805587).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2012 High

    Established NRP2 as a class 3 semaphorin receptor required for nervous system wiring, defining its founding role in axon guidance.

    Evidence Nrp2/Sema3F single and compound knockout mice with neuroanatomical phenotyping of the sympathetic nervous system

    PMID:22790009

    Open questions at the time
    • Does not resolve the receptor complex stoichiometry with plexins in vivo
    • Molecular signalling output downstream of NRP2 not dissected
  2. 2013 Medium

    Extended NRP2 function beyond neurons to skeletal tissue, showing it balances osteoblast and osteoclast activity in bone homeostasis.

    Evidence Nrp2 knockout mouse bone analysis with in vitro osteogenic/osteoclast differentiation assays

    PMID:23598046

    Open questions at the time
    • Ligand and plexin coreceptor driving the bone phenotype not pinpointed
    • Cell-autonomous versus systemic contribution unresolved
  3. 2016 Medium

    Identified a nuclear/transcriptional consequence of NRP2 signalling, linking it to WDFY1 repression and sustained endocytosis in metastatic cells.

    Evidence NRP2 knockdown/overexpression with nuclear fractionation and transcription reporter assays

    PMID:27026195

    Open questions at the time
    • Mechanism connecting surface NRP2 to FAC1 nuclear exclusion unclear
    • Single-lab finding without orthogonal confirmation
  4. 2017 High

    Defined NRP2 as a viral entry receptor and showed its semaphorin guidance role operates at the level of specific circuit formation and behaviour.

    Evidence Genome-wide haploid screen with KO/overexpression and binding for Lujo virus; mitral-cell-specific conditional Nrp2 KO with behavioural assays for olfactory circuits

    PMID:28731029 PMID:29120745

    Open questions at the time
    • Structural basis of LUJV glycoprotein-NRP2 binding not solved
    • Whether viral and semaphorin binding use overlapping NRP2 surfaces unknown
  5. 2020 Medium

    Resolved NRP2's role in endothelial migration as integrin- and VEGF-independent, acting through ITGA5 recycling, Rac-1, and the SSH1/cofilin cytoskeletal axis.

    Evidence siRNA knockdown in endothelial cells with adhesion/migration, integrin recycling assays, and SSH1 silencing rescue in tumour angiogenesis models

    PMID:32528960 PMID:32983407

    Open questions at the time
    • Direct biochemical link between NRP2 and SSH1/Rac regulators not established
    • Coreceptor requirement for cytoskeletal signalling undefined
  6. 2022 Medium

    Positioned NRP2 within disturbed-flow endothelial pathology and innate immunity, coupling it to GATA2-driven expression, VEGF-C complex formation, and macrophage-neutrophil interactions.

    Evidence HUVEC knockdown/overexpression with PARP1 readouts and Apoe-/- atherosclerosis model; promoter binding and co-IP for GATA2 and VEGF-C; conditional AM-specific NRP2 KO in E. coli pneumonia

    PMID:35028975 PMID:35435271 PMID:36764279

    Open questions at the time
    • Whether VEGF-C complex directly drives PARP1 induction not tested
    • Receptor partners mediating neutrophil binding by macrophage NRP2 unidentified
  7. 2024 Medium

    Mapped transcriptional control of NRP2 by SMAD2 and FOXA1, embedding it in TGFβ-driven EMT and endothelial injury responses.

    Evidence ChIP and luciferase promoter assays with siRNA rescue in endometrial stromal cells and LPS-treated HUVECs

    PMID:36306654 PMID:39435415

    Open questions at the time
    • Opposing activation (SMAD2) versus repression (FOXA1) context-dependence not reconciled
    • Single-lab promoter findings
  8. 2025 High

    Defined NRP2 as a druggable immune and signalling hub: a co-inhibitory T-cell receptor, a receptor for HARSWHEP, CD3L1, and PROX1-linked macrophage programs, and a FAK-activating oncogenic node amenable to plexin-dimerizing antibodies.

    Evidence Structural and binding studies of HARSWHEP and bispecific NRP2/PLXNA1 antibody; receptor identification for CD3L1 and migrasome-transferred NRP2; CD4+ T-cell-specific KO models; direct FAK binding and agonist rescue in GBM

    PMID:40073151 PMID:40402249 PMID:41361466 PMID:41391772 PMID:42141271

    Open questions at the time
    • Whether immune, viral, and semaphorin functions share one NRP2 conformation/site is unresolved
    • Endothelial junction and T-cell co-inhibition data remain in preprint form
    • Unifying structural model across diverse ligands lacking

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single co-receptor integrates such divergent ligands (semaphorins, VEGF-C, viral glycoproteins, HARSWHEP, CD3L1, TGFβ1) into context-specific outputs through distinct binding surfaces and coreceptor partners remains unresolved.
  • No comprehensive structural map of NRP2 ligand-binding sites
  • Coreceptor selection rules across tissues unknown
  • Causal hierarchy among NRP2's many downstream pathways undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0098772 molecular function regulator activity 3 GO:0001618 virus receptor activity 2 GO:0038024 cargo receptor activity 1
Localization
GO:0005886 plasma membrane 3
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 4 R-HSA-1266738 Developmental Biology 2 R-HSA-1643685 Disease 2
Partners
CD3L1FAC1FAKPLXNA1PROX1TGFB1VEGFC
Complex memberships
NRP2/PlexinA1 receptor complexendothelial adherens junction

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 NRP2 serves as a host cell entry receptor for Lujo virus (LUJV); LUJV glycoprotein binds the N-terminal domain of NRP2, and cells lacking NRP2 are deficient in wild-type LUJV infection. Overexpression of NRP2 or its N-terminal domain enhances VSV-LUJV infection. Genome-wide haploid genetic screen, receptor overexpression/knockout, binding assay with recombinant VSV-LUJV Cell host & microbe High 29120745
2012 NRP2 acts as a receptor for class 3 semaphorins (SEMA3F) and mediates axon guidance and migration in the sympathetic nervous system. Loss of NRP2/SEMA3F signaling impairs sympathetic gangliogenesis and causes ectopic neurite extension. NRP1 and NRP2 cooperate in SNS development as demonstrated by compound mutant analysis. Genetic mouse knockout (Nrp2-/-, Sema3F-/-, compound mutants), neuroanatomical phenotyping Developmental biology High 22790009
2020 NRP2 promotes endothelial cell (EC) adhesion and migration over fibronectin via a Rac-1-dependent mechanism that is independent of β3 integrin (ITGB3) and VEGF stimulation. NRP2 regulates α5 integrin (ITGA5) recycling in ECs; NRP2-depleted ECs show upregulated ITGA5 expression, disrupted ITGA5 organization, and reduced total ITGA5 recycling. siRNA knockdown in ECs, adhesion/migration assays on fibronectin, flow cytometry, integrin recycling assays Frontiers in cell and developmental biology Medium 32528960
2016 NRP2 negatively regulates WDFY1 transcription by preventing nuclear localization of the transcription factor FAC1. Maintaining WDFY1 at sub-optimal levels sustains high endocytic activity in metastatic cancer cells. NRP2 knockdown/overexpression, nuclear fractionation, transcription reporter assays, endocytic activity assays Scientific reports Medium 27026195
2020 NRP2 promotes angiogenesis in pancreatic neuroendocrine tumors (PNETs) via a VEGF/VEGFR2-independent pathway by activating F-actin polymerization through the SSH1/cofilin axis. Silencing SSH1 abrogated NRP2-activated HUVEC migration and F-actin polymerization. Plasmid constructs with mutant variants, Western blot, immunofluorescence, tube formation and wound-healing assays, in vivo mouse tumor model with NRP2 antibody Cell & bioscience Medium 32983407
2013 Nrp2 is expressed in osteoblasts and osteoclasts in bone, and Nrp2 knockout mice display trabecular bone loss accompanied by increased osteoclast numbers and decreased osteoblast counts, indicating a role for NRP2 in bone homeostasis. Nrp2 is co-expressed with plexin family coreceptors and class 3 semaphorin ligands during osteogenic differentiation. Nrp2 knockout mouse analysis, immunohistochemistry, in vitro osteogenic/osteoclast differentiation assays Bone Medium 23598046
2017 NRP2 expressed in mitral cells mediates their migration to the posteroventral olfactory bulb and axonal projection to the anterior medial amygdala in response to Semaphorin 3F. MC-specific Nrp2 knockout impairs circuit formation and abolishes odour-induced attractive social responses. MC-specific conditional Nrp2 knockout mice, in utero electroporation, behavioral assays Nature communications High 28731029
2022 NRP2 promotes endothelial cell apoptosis under low shear stress (LSS) by upregulating PARP1 protein expression, which modulates downstream apoptosis-related gene expression. Transcription factor GATA2 was identified as an upstream regulator that drives NRP2 expression. NRP2 knockdown in Apoe-/- mice markedly reduced atherosclerosis. siRNA knockdown and overexpression in HUVECs, Western blot, apoptosis assays, Apoe-/- mouse model, GATA2 transcription factor analysis FASEB journal Medium 35028975
2023 GATA2 regulates NRP2 transcription by binding to the −1100 to +100 bp region of the NRP2 promoter. NRP2 forms a complex with VEGF-C under disturbed flow in endothelial cells, promoting inflammation. Quercetin inhibits the NRP2-VEGF-C complex formation. Promoter binding assay, co-immunoprecipitation for NRP2-VEGFC complex, siRNA knockdown, HUVEC disturbed flow model International immunopharmacology Medium 36764279
2021 In gastric cancer, CAF-expressed NRP2 promotes chemoresistance by stimulating SDF-1 secretion via VEGF/NRP2 signaling in CAFs, which in turn activates the Hippo pathway (YAP/TAZ) in cancer cells. NRP2 knockdown in CAFs reduced SDF-1 secretion and restored cancer cell sensitivity to 5-FU. RNA-sequencing, CAF/cancer cell co-culture, siRNA knockdown, viability and apoptosis assays Gastric cancer Medium 34826008
2022 MUC16 regulates NRP2 expression via the JAK2/STAT1 signaling axis in pancreatic ductal adenocarcinoma cells. NRP2 knockdown in MUC16-overexpressed cells significantly decreased cell adhesion and migration, placing NRP2 downstream of MUC16-JAK2/STAT1 in liver metastasis. RNA-sequencing, siRNA knockdown, overexpression, cell adhesion and migration assays, in vivo mouse liver metastasis model Molecular cancer research : MCR Medium 35533267
2020 NRP2 binds TGFβ1 and associates with TGFβ receptors, enhancing TGFβ1 signaling. TGFβ1-dependent regulation of NRP2 and GLI2 expression promotes EMT in bladder cancer. NRP2 positively regulates SPP1/Osteopontin as a downstream effector, validated in NRP2 knockout and knockdown models. NRP2 KO and knockdown models, PCR profiling array (84 EMT genes), correlation analysis in TCGA cohort and cell lines, TGFβ1 stimulation assays Frontiers in oncology Medium 32038994
2025 HARSWHEP (a splice variant of histidyl-tRNA synthetase) binds specifically and selectively to NRP2 via a helix-turn-helix motif. This interaction on myeloid cells inhibits proinflammatory receptor and cytokine expression and down-regulates inflammatory pathways in primary human macrophages. In animal models of ILD, HARSWHEP reduced lung inflammation and fibrosis through NRP2. Structural analysis (helix-turn-helix motif), binding assays, primary human macrophage assays, multiple animal models of lung injury/ILD Science translational medicine High 40073151
2025 A bispecific antibody that dimerizes NRP2 with PLXNA1 mimics SEMA3F-mediated signaling (receptor dimerization, phospho-AKT suppression, oncogene suppression, antiproliferative effects). Structural studies revealed the bsAb binds NRP2 and PLXNA1 at sites distinct from the SEMA3F-binding site but allows proper receptor complex formation and conformational flexibility for signaling. Cell-based receptor dimerization assays, phospho-AKT assay, cell proliferation assay, structural studies of antibody binding The Journal of biological chemistry High 41391772
2022 Alveolar macrophage (AM)-derived NRP2 physically binds CD11b+ Ly6Glo/+ neutrophils and promotes their phagocytosis and bacterial killing capacity, partly through increased TLR4 and TNF-α expression. Conditional deletion of NRP2 in AMs resulted in persistent bacteria, uncontrolled neutrophil influx, and decreased survival during E. coli pneumonia. Conditional AM-specific NRP2 KO mice, in vitro binding and phagocytosis assays, E. coli pneumonia model Journal of leukocyte biology Medium 35435271
2025 CD3L1 (ITPRIPL1) signals through NRP2 as its primary receptor on macrophages, constituting the CD3L1-NRP2 axis that drives immunosuppressive M2 TAM polarization. NRP2 KO or anti-CD3L1 treatment reprogrammed TAMs toward M1 anti-tumor phenotype and suppressed tumor progression in T-cell-deficient models. Mechanistic studies in T-cell deficient osteosarcoma models, receptor identification, macrophage polarization assays, in vivo tumor models EMBO molecular medicine Medium 42141271
2025 NRP2 functions as a co-inhibitory receptor on CD4+ T effector cells. NRP2 is co-expressed with PD-1, CTLA4, TIGIT, LAG3, and TIM3 on exhausted/late effector CD4+ T cells. Knockout of NRP2 results in hyperactive CD4+ T cell responses, accelerated allograft rejection, and enhanced delayed-type hypersensitivity. The co-inhibitory function is specific to NRP2 on T effectors, not Treg cells. Humanized SCID mice, global and CD4+ T cell-specific KO mouse models, cardiac transplantation model, delayed-type hypersensitivity model, in vitro Treg suppression assays bioRxivpreprint Medium
2025 NRP2 is a component of endothelial adherens junctions where it maintains VE-cadherin surface availability by promoting its interaction with p120 catenin. Endothelial-specific Nrp2 knockout mice display hyperpermeable retinal vasculature, upregulation of pro-inflammatory cytokines and adhesion molecules, increased immune cell attachment, and aortic plaque development. Endothelial-specific Nrp2 knockout mouse model, cultured immortalized mouse ECs, co-immunoprecipitation of VE-cadherin and p120 catenin, retinal vascular permeability assay, aortic plaque assessment bioRxivpreprint Medium
2025 Guinea pig NRP2 interacts with the CMV pentamer complex (PC) in immunoprecipitation assays, functioning as an endocytic cell entry receptor. Double knockout of PDGFRA and NRP2 completely blocked GPCMV infection, while CD147/PDGFRA double KO had only limited inhibition. Immunoprecipitation, double KO cell lines, ectopic receptor re-expression, viral infection assays The Journal of general virology Medium 41805587
2023 Sema3G signals through the Nrp2/PlexinA1 receptor complex to inhibit LATS1 and activate YAP in vascular smooth muscle cells, promoting their proliferation and migration. MMP2 and MMP9 upregulation underlies enhanced migration. Verteporfin (YAP inhibitor) counteracted Sema3G-induced cyclin E and cyclin D1 expression. Nrp2/PlexinA1 inhibition, Western blot for LATS1/YAP phosphorylation, cell proliferation/migration assays, pharmacological inhibition with verteporfin Cellular signalling Medium 36720439
2025 NRP2 activates FAK phosphorylation through direct binding to FAK, thereby activating the focal adhesion pathway and promoting GBM cell proliferation, migration, and invasion. NRP2 knockdown inhibited GBM growth in vivo, and this inhibition was reversed by FAK agonists. NRP2 knockdown (in vitro and in vivo), FAK phosphorylation assays, direct binding assay, FAK agonist rescue experiments, animal tumor model Translational oncology Medium 41861662
2025 NRP2 expressed on colorectal cancer-derived migrasomes is transferred to macrophages, where it binds PROX1 to drive CD5L expression and upregulate efferocytosis receptors, promoting M2-like macrophage polarization and tumor immune evasion. NRP2 knockdown in CRC cells abrogated migrasome-induced CD5L+ macrophage polarization. scRNA-seq, in vivo liver metastasis model, NRP2 KD, migrasome transfer assays, binding assay (NRP2-PROX1) Journal of translational medicine Medium 41361466
2025 In colorectal cancer, cancer-associated fibroblast-secreted SEMA3C binds the NRP2 receptor on liver metastasis-initiating cells, activating the MAPK pathway and promoting liver metastasis. Confirmed by in vivo and in vitro experiments. Time-resolved spatial transcriptomics, scRNA-seq, in vivo and in vitro SEMA3C-NRP2 signaling assays, MAPK pathway analysis Proceedings of the National Academy of Sciences of the United States of America Medium 40402249
2022 NRP2 is dynamically redistributed to the basolateral membrane compartment of polarized HUVECs upon basolateral VEGF-A stimulation, co-redistributing with VEGFR2. This basolateral localization correlates with enhanced endothelial permeability. Immunocytochemistry and confocal z-section imaging, Transwell permeability assay, quantitative fluorescence intensity measurement The journal of histochemistry and cytochemistry Medium 35876388
2024 TGF-β signaling activates SMAD2, which transcriptionally upregulates NRP2 expression in ectopic endometrial stromal cells (ESCs). NRP2 depletion suppressed ESC migration, invasion, and EMT. TGF-β treatment rescued NRP2 silencing-induced suppression. ChIP assay confirming SMAD2 binding to NRP2 promoter, luciferase reporter assay, siRNA knockdown, transwell migration/invasion assays, Western blot for EMT markers Reproductive biology Medium 36306654
2024 FOXA1 binds to the NRP2 promoter and suppresses NRP2 transcription, exacerbating LPS-induced endothelial cell injury. Knockdown of NRP2 offset the protective effect of FOXA1 knockdown, placing NRP2 downstream of FOXA1 in the septic endothelial injury pathway. ChIP assay, dual-luciferase assay for FOXA1-NRP2 promoter binding, siRNA knockdown rescue experiments, HUVEC LPS model Cytotechnology Medium 39435415
2022 NRP2 promotes sorafenib resistance in clear cell renal cell carcinoma through the NRP2/NF-κB/TNFα axis. The TNF-α inhibitor adalimumab reversed NRP2-mediated sorafenib resistance. NRP2 overexpression/knockdown in ccRCC cells, NF-κB pathway analysis, pharmacological rescue with adalimumab, cell proliferation/migration/invasion assays American journal of cancer research Low 41395296

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3. Cancer letters 136 23142217
2017 NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell host & microbe 110 29120745
2012 NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Developmental biology 67 22790009
2018 NRP-2 in tumor lymphangiogenesis and lymphatic metastasis. Cancer letters 64 29339213
2023 Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 57 37661565
2016 Pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis in tumor lymphangiogenesis and lymphatic metastasis. Clinica chimica acta; international journal of clinical chemistry 48 27527412
2016 MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2. International journal of molecular sciences 48 27548144
2021 CAF promotes chemoresistance through NRP2 in gastric cancer. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 45 34826008
2020 NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 Integrin. Frontiers in cell and developmental biology 43 32528960
2013 Nrp2 deficiency leads to trabecular bone loss and is accompanied by enhanced osteoclast and reduced osteoblast numbers. Bone 42 23598046
2007 Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 40 17427189
2021 FOXM1 accelerates wound healing in diabetic foot ulcer by inducing M2 macrophage polarization through a mechanism involving SEMA3C/NRP2/Hedgehog signaling. Diabetes research and clinical practice 39 34742786
2017 Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses. Nature communications 36 28731029
2007 Myeloid leukemias express a broad spectrum of VEGF receptors including neuropilin-1 (NRP-1) and NRP-2. Leukemia & lymphoma 29 17917967
2022 MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion. Molecular cancer research : MCR 27 35533267
2022 The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways. Environmental toxicology 27 36136913
2020 Linking NRP2 With EMT and Chemoradioresistance in Bladder Cancer. Frontiers in oncology 26 32038994
2020 miR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2. Technology in cancer research & treatment 26 32174262
2018 ARFHPV E7 oncogene, lncRNA HOTAIR, miR-331-3p and its target, NRP2, form a negative feedback loop to regulate the apoptosis in the tumorigenesis in HPV positive cervical cancer. Journal of cellular biochemistry 26 29130509
2022 NRP2 promotes atherosclerosis by upregulating PARP1 expression and enhancing low shear stress-induced endothelial cell apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24 35028975
2019 miR-331-3p suppresses cell invasion and migration in colorectal carcinoma by directly targeting NRP2. Oncology letters 22 31807170
2016 NRP2 transcriptionally regulates its downstream effector WDFY1. Scientific reports 22 27026195
2022 Circ_CHFR Promotes Platelet-Derived Growth Factor-BB-Induced Proliferation, Invasion, and Migration in Vascular Smooth Muscle Cells via the miR-149-5p/NRP2 Axis. Journal of cardiovascular pharmacology 21 33990513
2021 Stress response proteins NRP1 and NRP2 are pro-survival factors that inhibit cell death during ER stress. Plant physiology 21 34618053
2006 Hormonal regulation and differential expression of neuropilin (NRP)-1 and NRP-2 genes in bovine granulosa cells. Reproduction (Cambridge, England) 19 16514198
2022 LRP11-AS1 promotes the proliferation and migration of triple negative breast cancer cells via the miR-149-3p/NRP2 axis. Cancer cell international 18 35279146
2018 Low Expression of miR-466f-3p Sustains Epithelial to Mesenchymal Transition in Sonic Hedgehog Medulloblastoma Stem Cells Through Vegfa-Nrp2 Signaling Pathway. Frontiers in pharmacology 18 30483126
2019 Expression of NRP-1 and NRP-2 in Endometrial Cancer. Current pharmaceutical biotechnology 17 30806307
2021 Circ-LDLRAD3 Enhances Cell Growth, Migration, and Invasion and Inhibits Apoptosis by Regulating MiR-224-5p/NRP2 Axis in Gastric Cancer. Digestive diseases and sciences 15 33389349
2020 Vascular NRP2 triggers PNET angiogenesis by activating the SSH1-cofilin axis. Cell & bioscience 14 32983407
2020 MiR-146a Regulates Migration and Invasion by Targeting NRP2 in Circulating-Tumor Cell Mimicking Suspension Cells. Genes 12 33396906
2024 miR-200-mediated inactivation of cancer-associated fibroblasts via targeting of NRP2-VEGFR signaling attenuates lung cancer invasion and metastasis. Molecular therapy. Nucleic acids 11 38766528
2023 Uterine inflammatory myofibroblastic tumor harboring novel NUDCD3-ROS1 and NRP2-ALK fusions: clinicopathologic features of 4 cases and literature review. Virchows Archiv : an international journal of pathology 11 36624188
2023 Quercetin protects endothelial function from inflammation induced by localized disturbed flow by inhibiting NRP2 -VEGFC complex. International immunopharmacology 11 36764279
2025 Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation. Proceedings of the National Academy of Sciences of the United States of America 10 40402249
2023 Sema3G activates YAP and promotes VSMCs proliferation and migration via Nrp2/PlexinA1. Cellular signalling 10 36720439
2022 Exosomal miR-328 originated from pulmonary adenocarcinoma cells enhances osteoclastogenesis via downregulating Nrp-2 expression. Cell death discovery 9 36192384
2022 Alveolar macrophage-derived NRP2 curtails lung injury while boosting host defense in bacterial pneumonia. Journal of leukocyte biology 8 35435271
2022 A Novel circUBR4/miR-491-5p/NRP2 ceRNA Network Regulates Oxidized Low-density Lipoprotein-induced Proliferation and Migration in Vascular Smooth Muscle Cells. Journal of cardiovascular pharmacology 7 34935701
2022 The activation of TGF-β signaling promotes cell migration and invasion of ectopic endometrium by targeting NRP2. Reproductive biology 6 36306654
2023 Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation. Viruses 5 37515185
2022 Ruscogenin Attenuates Lipopolysaccharide-Induced Septic Vascular Endothelial Dysfunction by Modulating the miR-146a-5p/NRP2/SSH1 Axis. Drug design, development and therapy 5 35440867
2022 CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer. Medical oncology (Northwood, London, England) 5 36567417
2021 NRP2, a potential biomarker for oral squamous cell carcinoma. American journal of translational research 5 34540006
2015 Preparation, Purification, and Identification of a Monoclonal Antibody Against NRP2 b1b2 Domain. Monoclonal antibodies in immunodiagnosis and immunotherapy 5 26492624
2025 A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis. Science translational medicine 3 40073151
2024 MiR-331-3p facilitates osteoporosis and may promote osteoporotic fractures by modulating NRP2 expression. Journal of orthopaedic surgery and research 3 39154011
2024 FOXA1 exacerbates LPS-induced vascular endothelial cell injury in sepsis by suppressing the transcription of NRP2. Cytotechnology 3 39435415
2023 Association of plasma NRP2 and VEGF-C levels with prostate cancer disease severity. The Prostate 3 37942701
2022 Quantitative Assessment of the Apical and Basolateral Membrane Expression of VEGFR2 and NRP2 in VEGF-A-stimulated Cultured Human Umbilical Vein Endothelial Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 3 35876388
2022 Single dose S-ketamine rescues transcriptional dysregulation of Mtor and Nrp2 in the prefrontal cortex of FSL rats 1 hour but not 14 days post dosing. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 3 36375239
2020 Segregation Analysis of Rare NRP1 and NRP2 Variants in Families with Lymphedema. Genes 3 33212964
2025 MBsNRP2-based ultrasound molecular imaging for early diagnosis of castration-resistant prostate cancer. BMC cancer 2 40275166
2025 Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19. Journal of virology 2 41159753
2025 Hypoxic migrasomes drive colorectal cancer liver metastasis by mediating CD5L+ macrophage efferocytosis via NRP2/PROX1 axis. Journal of translational medicine 2 41361466
2024 The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma. Breast cancer research : BCR 2 39138514
2023 CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2 37813099
2021 Colorectal Carcinoma Growth Inhibition by Dietary Care Combined with Probiotic Intervention through Targeting NRP2 Expression. Doklady. Biochemistry and biophysics 2 34697743
2026 Knockout of key receptors (PDGFRA and NRP2) in the guinea pig model blocks direct and endocytic pathways of CMV cell entry. The Journal of general virology 0 41805587
2026 The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study. Translational oncology 0 41861662
2026 Response to: "Re-examining interneuron-specific Nrp2 deletion: overlooked striatal and cortical contributions". Molecular psychiatry 0 41974886
2026 Targeting CD3L1-NRP2 disarms myeloid-driven tumor immune evasion. EMBO molecular medicine 0 42141271
2025 NRP2+ human mesenchymal stem cells have stemness-associated properties. Inflammation and regeneration 0 40289176
2025 BMSC-EVs improve post-stroke cognition by promoting regionally distinct synaptic repair via Sema3G-Nrp2/PlexinA4 Signaling. Experimental neurology 0 41270983
2025 A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F. The Journal of biological chemistry 0 41391772
2025 Neuropilin-2 (NRP2) mediates sorafenib resistance in clear cell renal cell carcinoma via the NRP2/NF-κB/TNFα axis. American journal of cancer research 0 41395296

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