Affinage

PLXNA1

Plexin-A1 · UniProt Q9UIW2

Round 2 corrected
Length
1896 aa
Mass
211.1 kDa
Annotated
2026-04-28
130 papers in source corpus 15 papers cited in narrative 15 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PLXNA1 (Plexin-A1) is a transmembrane semaphorin receptor that transduces repulsive guidance and morphogenetic signals by coupling ligand-induced relief of sema-domain autoinhibition to an intrinsic cytoplasmic GAP-like domain that engages Rnd1 and RhoD GTPases, ultimately triggering cytoskeletal collapse, growth cone retraction, and cell migration control (PMID:10520994, PMID:11239433, PMID:11784792, PMID:11108845). PLXNA1 forms obligate or context-dependent complexes with neuropilin-1 (NRP1) to bind class-3 semaphorins such as Sema3A, and with alternative co-receptors (VEGFR2, Off-track, TREM-2/DAP12, CRAF) to activate MAPK or AKT cascades in cardiac morphogenesis, immune regulation, bone homeostasis, and cancer drug resistance (PMID:14977921, PMID:16715077, PMID:35508542, PMID:39226661). In vivo, PLXNA1 cooperates redundantly with PLXNA3 to pattern nasal axons and guide GnRH neuron migration during development (PMID:31690636). Biallelic and monoallelic PLXNA1 variants cause a neurodevelopmental syndrome with CNS and eye abnormalities (PMID:34054129).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1996 High

    The initial identification of PLXNA1 as a novel transmembrane protein with a MET-like ectodomain but no intrinsic tyrosine kinase activity posed the question of how it signals.

    Evidence cDNA cloning, Northern blot, chimeric receptor constructs in heterologous cells

    PMID:8570614

    Open questions at the time
    • No ligand identified for the receptor
    • Cytoplasmic signaling mechanism unknown
    • Tissue-specific functions not addressed
  2. 1999 High

    Demonstration that Plexin-A1 forms a complex with NRP1 and is the obligate signal-transducing component of the Sema3A receptor resolved the long-standing question of how neuropilins, which lack substantial cytoplasmic domains, trigger intracellular signaling.

    Evidence Reciprocal co-immunoprecipitation of Plexin-A1/NRP1, ligand binding assays, dominant-negative Plexin-A1 blocking Sema3A-induced growth cone collapse in DRG neurons

    PMID:10520994 PMID:10520995

    Open questions at the time
    • Mechanism of signal transduction across the membrane not known
    • Whether Plexin-A1 functions independently of NRP1 for other semaphorins not established
  3. 2000 Medium

    Discovery of a RasGAP/RhoGAP-like catalytic domain within the Plexin-A1 cytoplasmic region, and the requirement of conserved catalytic arginines for growth cone collapse, provided the first mechanistic model for how plexins transduce signals — through intrinsic GTPase-activating activity.

    Evidence Sequence homology analysis plus site-directed mutagenesis of catalytic arginine residues with growth cone collapse readout

    PMID:11108845

    Open questions at the time
    • GAP activity not directly reconstituted in vitro
    • Substrate GTPase identity unknown at this stage
    • Whether GAP activity is regulated by ligand binding not tested
  4. 2001 High

    Establishing that Plexin-A1 is autoinhibited by its own sema domain explained how the receptor remains quiescent in the absence of ligand and how ligand binding could relieve inhibition to activate the cytoplasmic domain.

    Evidence Sema-domain deletion mutagenesis yielding constitutive activity; rescue by co-expression of the isolated sema domain fragment; co-IP of ectodomain fragments

    PMID:11239433

    Open questions at the time
    • Structural basis of autoinhibition not resolved
    • Whether ligand binding displaces the sema domain or induces a conformational change not distinguished
  5. 2002 High

    Identification of Rnd1 as an activating GTPase and RhoD as an antagonistic GTPase that bind the Plexin-A1 cytoplasmic domain defined the immediate downstream GTPase relay controlling cytoskeletal collapse.

    Evidence Systematic GST-pulldown screen of Rho-family GTPases, functional epistasis using dominant-active/negative GTPases in growth cone collapse and axon repulsion assays

    PMID:11784792

    Open questions at the time
    • Direct GAP activity of Plexin-A1 on Rnd1/RhoD not biochemically measured
    • How Rnd1 binding activates Plexin-A1 mechanistically not resolved
  6. 2003 Medium

    The finding of an autocrine SEMA3A/Plexin-A1/NRP1 pathway restraining breast cancer cell migration extended Plexin-A1's role beyond axon guidance to tumor biology.

    Evidence siRNA knockdown of SEMA3A and NRP1, constitutively active Plexin-A1 expression, Boyden chamber chemotaxis assays in breast carcinoma lines

    PMID:14500350

    Open questions at the time
    • Downstream effectors mediating anti-migratory signaling in cancer cells not identified
    • Relevance to in vivo tumor progression not tested in this study
  7. 2004 High

    Discovery that Plexin-A1 assembles distinct co-receptor complexes — with VEGFR2 to promote migration and with Off-track to inhibit migration — in different cardiac regions resolved how a single semaphorin (Sema6D) can exert opposing effects through the same receptor.

    Evidence Reciprocal co-IP of VEGFR2/Plexin-A1 and Off-track/Plexin-A1 complexes in chick cardiac tissue, RNAi and ectopic expression in embryo, cardiac explant migration assays

    PMID:14977921

    Open questions at the time
    • Molecular determinants governing co-receptor choice not identified
    • Downstream signaling divergence between the two complexes not characterized
  8. 2006 High

    Plexin-A1 knockout mice revealed essential non-neuronal functions: association with TREM-2/DAP12 links Plexin-A1 to T-cell activation and osteoclast-mediated bone remodeling, demonstrating that semaphorin-plexin signaling is a core immune and skeletal pathway.

    Evidence Plexin-A1 knockout mice with immune challenge phenotyping, bone histomorphometry, co-IP of Plexin-A1/TREM-2/DAP12 complex

    PMID:16715077

    Open questions at the time
    • Semaphorin ligand activating this immune complex not definitively identified
    • Signaling cascade downstream of DAP12 ITAM in this context not dissected
  9. 2019 High

    Double-knockout epistasis in mice proved that PLXNA1 and PLXNA3 are redundant, essential co-receptors for Sema3A in patterning nasal axons and enabling GnRH neuron migration, connecting Plexin-A1 to neuroendocrine development.

    Evidence Plxna1/Plxna3 single and double knockout mice phenocopying Sema3a KO; immunofluorescence of nasal axons and GnRH neurons

    PMID:31690636

    Open questions at the time
    • Whether PLXNA1 has a unique non-redundant role in GnRH biology apart from PLXNA3 is unclear
    • Human genetic validation for GnRH-related disease not yet established
  10. 2019 Medium

    PLXNA1 was shown to activate the MAPK cascade in esophageal squamous cell carcinoma, placing it upstream of a major proliferative signaling axis in an epithelial cancer context.

    Evidence miR-134/PLXNA1 3'UTR dual-luciferase validation, PLXNA1 knockdown, MAPK pathway western blots, xenograft models

    PMID:31383552

    Open questions at the time
    • Direct mechanism linking Plexin-A1 to MAPK activation not defined
    • Intermediate effectors between PLXNA1 and MAPK not identified in this system
  11. 2021 Medium

    Identification of biallelic and monoallelic PLXNA1 variants in patients with a novel neurodevelopmental syndrome, supported by zebrafish knockdown phenocopying CNS and eye defects, established PLXNA1 as a disease gene for human neurodevelopment.

    Evidence Genotype-phenotype study of 10 patients, structural modeling of variants, morpholino knockdown in zebrafish

    PMID:34054129

    Open questions at the time
    • Biochemical effect of individual disease variants on Plexin-A1 activity not reconstituted
    • Mammalian model validation (mouse knock-in of patient variants) lacking
    • Dominant-negative mechanism for monoallelic intracellular-domain variants is modeled, not proven
  12. 2022 Medium

    The RUVBL1-CRAF-PLXNA1 axis was identified as a mechanism for enzalutamide resistance in prostate cancer, revealing Plexin-A1 as a scaffold for MAPK pathway re-activation that bypasses androgen receptor signaling.

    Evidence Co-IP of RUVBL1/CRAF/PLXNA1 complex, pharmacological inhibition with CB-6644, xenograft models

    PMID:35508542

    Open questions at the time
    • Direct binding interface between PLXNA1 and CRAF not mapped
    • Whether semaphorin ligand is required for this scaffold function unknown
  13. 2024 Medium

    PLXNA1 was shown to recruit NRP1 to potentiate AKT signaling in enzalutamide-resistant prostate cancer, and pharmacological disruption of the PLXNA1-NRP1 complex with EG01377 abolished resistance, revealing a druggable co-receptor complex driving therapy resistance.

    Evidence Co-IP of PLXNA1-NRP1, NRP1 inhibitor (EG01377) and AKT inhibitor treatment, pAKT western blot, cell proliferation under enzalutamide

    PMID:39226661

    Open questions at the time
    • In vivo validation of NRP1 inhibitor efficacy against PLXNA1-driven resistance not reported
    • Whether MAPK and AKT pathways are activated independently or sequentially by PLXNA1 complexes is unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions remain: the structural basis of Plexin-A1 autoinhibition relief upon ligand binding, the direct biochemical reconstitution of its GAP activity against specific Ras/Rho substrates, the determinants governing co-receptor selection in different tissues, and whether PLXNA1 disease variants cause loss-of-function or gain-of-function at the protein level.
  • No high-resolution structure of full-length Plexin-A1 in autoinhibited vs. activated states
  • GAP activity not reconstituted biochemically with purified components
  • Molecular rules dictating co-receptor selection (NRP1 vs. VEGFR2 vs. Off-track vs. TREM-2/DAP12) remain unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005886 plasma membrane 3 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-112316 Neuronal System 3 R-HSA-1266738 Developmental Biology 2 R-HSA-168256 Immune System 1
Partners
CRAFNRP1RHODRND1SEMA3ASEMA6DTREM2TYROBP
Complex memberships
Plexin-A1/NRP1 semaphorin receptor complexPlexin-A1/TREM-2/DAP12 complexPlexin-A1/VEGFR2 complex

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 PLXNA1 (originally named NOV/SEX family member) was identified as a transmembrane protein of ~220 kDa with homology to the MET/HGF receptor extracellular domain; it is glycosylated and cell-surface exposed but lacks tyrosine kinase activity despite containing a distinctive conserved cytoplasmic 'SEX domain', suggesting a novel receptor mechanism. cDNA cloning, Northern blot, in situ hybridization, cell-surface expression assays, chimeric receptor constructs Proceedings of the National Academy of Sciences of the United States of America High 8570614
1999 Plexin-A1 is a functional semaphorin receptor: plexin-A1 associates stably with neuropilin-1 (NRP1), and this NRP1/Plexin-A1 complex binds Sema3A with higher affinity than NRP1 alone; expression of dominant-negative Plexin-A1 in sensory neurons blocks Sema3A-induced growth cone collapse, establishing plexin-A1 as the signal-transducing subunit of the Sema3A receptor. Co-immunoprecipitation, receptor-ligand binding assays, dominant-negative expression in neurons, growth cone collapse assays Cell High 10520994 10520995
1999 Plexin-A1 is a direct receptor for multiple semaphorin classes either alone or in combination with neuropilins; expression of a truncated plexin-A1 in neurons blocks Sema3A-induced axon repulsion, and the cytoplasmic domain of plexin-A1 associates with a tyrosine kinase activity. Binding assays, dominant-negative truncation expression in neurons, co-immunoprecipitation for kinase activity Cell High 10520995
2000 The cytoplasmic domain of Plexin-A1 contains sequence similarity to RasGAP/RhoGAP catalytic domains; mutation of two conserved arginine residues corresponding to catalytic GAP residues abolishes Plexin-A1's ability to induce growth cone collapse, implying an intrinsic GAP activity essential for semaphorin signaling. Sequence analysis, site-directed mutagenesis of arginine residues, growth cone collapse assay FEBS letters Medium 11108845
2001 Plexin-A1 is autoinhibited by its own sema domain: deletion of the sema domain renders Plexin-A1 constitutively active (inducing cell contraction, growth cone collapse, and neurite outgrowth inhibition without ligand), and the isolated sema domain physically associates with the remainder of the Plexin-A1 ectodomain to reverse constitutive activation. Both the sema domain and the remainder of the ectodomain independently associate with NRP1. Deletion mutagenesis, cell morphology assays, growth cone collapse assay, co-immunoprecipitation of ectodomain fragments Neuron High 11239433
2002 Among a large panel of Rho-family GTPases tested, only Rnd1 and RhoD bind the cytoplasmic domain of Plexin-A1. Active Rnd1 is sufficient to trigger Plexin-A1 signaling and cytoskeletal collapse in the absence of Sema3A, while RhoD antagonizes Plexin-A1 activation by Rnd1 and blocks Sema3A-induced axon repulsion, revealing that antagonistic GTPases regulate Plexin-A1 activity. GST pulldown, co-immunoprecipitation, dominant-active/negative GTPase expression, growth cone collapse and axon repulsion assays The Journal of neuroscience High 11784792
2003 Breast carcinoma cells express an autocrine SEMA3A/Plexin-A1/NRP1 pathway that impedes chemotaxis; RNAi knockdown of SEMA3A or NRP1, or inhibition of Plexin-A1 signaling, enhances migration, while constitutively active Plexin-A1 impairs chemotaxis, establishing Plexin-A1 as an anti-migratory signal in cancer cells. siRNA knockdown, constitutively active Plexin-A1 expression, Boyden chamber chemotaxis assays Cancer research Medium 14500350
2004 Plexin-A1 is the primary receptor for Sema6D in cardiac morphogenesis. In the conotruncal segment, Plexin-A1 forms a complex with VEGFR2 and promotes cell migration; in the ventricular segment, Plexin-A1 associates with Off-track and inhibits migration. The differential co-receptor association of Plexin-A1 enables Sema6D to exert distinct, region-specific activities during cardiac morphogenesis. RNA interference, ectopic expression in chick embryos, co-immunoprecipitation of receptor complexes, cardiac explant migration assays Genes & development High 14977921
2006 Plexin-A1 associates with the ITAM-bearing adaptor protein DAP12 through the transmembrane receptor TREM-2. In plexin-A1-deficient mice, T-cell-dependent immune responses are impaired and bone homeostasis is disrupted (osteoclast defects), linking semaphorin signaling via Plexin-A1/TREM-2/DAP12 to immune activation and bone remodeling pathways beyond the nervous system. Plexin-A1 knockout mice, co-immunoprecipitation (Plexin-A1/TREM-2/DAP12 complex), immune challenge experiments, bone histomorphometry Nature cell biology High 16715077
2019 PLXNA1 and PLXNA3 cooperate as co-receptors for SEMA3A to pattern vomeronasal and olfactory axons that guide GnRH neuron migration. Combined loss of PLXNA1 and PLXNA3 in mice fully phenocopies the nasal axon defects and GnRH neuron migration failure seen in Sema3a knockout mice, while single knockouts do not, establishing PLXNA1 and PLXNA3 as redundant, essential co-receptors in GnRH neuron development. Genetic epistasis using single and double mouse knockouts (Plxna1−/−, Plxna3−/−, Plxna1/Plxna3 double KO vs. Sema3a KO), immunofluorescence of nasal axons and GnRH neurons Development (Cambridge, England) High 31690636
2019 PLXNA1 activates the MAPK signaling pathway in esophageal squamous cell carcinoma cells; miR-134 directly targets the PLXNA1 3'UTR (verified by dual-luciferase reporter assay) and suppresses PLXNA1 expression, thereby blocking MAPK pathway activation and reducing cell proliferation, migration, invasion, and tumor metastasis in vitro and in vivo. Dual-luciferase reporter assay (miR-134/PLXNA1 3'UTR interaction), siRNA knockdown, miR-134 mimic/inhibitor, western blot of MAPK pathway proteins, xenograft mouse models EBioMedicine Medium 31383552
2021 Biallelic and monoallelic variants in PLXNA1 cause a novel neurodevelopmental syndrome. Structural modeling indicates that missense variants in the extracellular domain likely impair Plexin-A1 dimerization or abolish receptor molecules, while monoallelic intracellular domain variants may exert a dominant-negative effect on downstream signaling. Morpholino knockdown of zebrafish plxna1a and plxna1b disrupts CNS and eye development, demonstrating an embryonic role for PLXNA1 in neurogenesis. Structural/homology modeling of missense variants, Morpholino knockdown in zebrafish (CNS and eye phenotype), genotype-phenotype correlation in 10 patients Genetics in medicine Medium 34054129
2022 RUVBL1 promotes enzalutamide resistance in prostate cancer through PLXNA1: enzalutamide increases cytoplasmic RUVBL1 accumulation, which enhances recruitment of CRAF to Plexin-A1 (PLXNA1), activating the downstream MAPK pathway and bypassing androgen receptor signaling. Co-immunoprecipitation (RUVBL1/CRAF/PLXNA1 complex), RUVBL1 inhibition with CB-6644, xenograft models, western blot of MAPK pathway activation Oncogene Medium 35508542
2024 PLXNA1 confers enzalutamide resistance in prostate cancer via AKT signaling: PLXNA1 recruits NRP1 to form a PLXNA1-NRP1 receptor complex, which potentiates AKT phosphorylation. Inhibition of the PLXNA1-NRP1 complex with the NRP1 inhibitor EG01377 or AKT inhibitors abolishes the pro-resistance phenotype of PLXNA1 overexpression. Co-immunoprecipitation (PLXNA1-NRP1 complex), NRP1 inhibitor (EG01377) treatment, AKT inhibitor treatment, western blot of pAKT, cell proliferation assays under enzalutamide Neoplasia Medium 39226661
2024 Truncated PLXNA1 functions as a novel scaffold protein for extracellular vesicle (EV) engineering: endogenous full-length PLXNA1 has high EV-sorting ability, and truncated PLXNA1 retains this property while permitting fusion expression of protein cargoes on both the outer EV surface and luminal areas. EV purification, western blot and flow cytometry for EV-sorted PLXNA1 fusion proteins, fluorescence microscopy of cargo delivery Journal of extracellular vesicles Medium 39508411

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
1999 Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 954 10520995
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
1999 Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 698 10520994
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2016 Genome-based phylogeny and taxonomy of the 'Enterobacteriales': proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov. International journal of systematic and evolutionary microbiology 631 27620848
2021 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 532 33845483
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2001 Phylogenetic analyses of Klebsiella species delineate Klebsiella and Raoultella gen. nov., with description of Raoultella ornithinolytica comb. nov., Raoultella terrigena comb. nov. and Raoultella planticola comb. nov. International journal of systematic and evolutionary microbiology 314 11411716
2004 Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes & development 242 14977921
2010 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunology and cell biology 221 20458337
2006 Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nature cell biology 216 16715077
2020 A phylogenomic and comparative genomic framework for resolving the polyphyly of the genus Bacillus: Proposal for six new genera of Bacillus species, Peribacillus gen. nov., Cytobacillus gen. nov., Mesobacillus gen. nov., Neobacillus gen. nov., Metabacillus gen. nov. and Alkalihalobacillus gen. nov. International journal of systematic and evolutionary microbiology 202 31617837
2002 Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. The Journal of biological chemistry 199 11886873
2003 Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer research 181 14500350
2001 Plexina1 autoinhibition by the plexin sema domain. Neuron 176 11239433
2006 ERp57 is essential for efficient folding of glycoproteins sharing common structural domains. The EMBO journal 171 17170699
2000 The semaphorin 3A receptor may directly regulate the activity of small GTPases. FEBS letters 158 11108845
2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut 157 19240061
2001 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome research 151 11230166
1996 A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. Proceedings of the National Academy of Sciences of the United States of America 149 8570614
2001 Thioalkalimicrobium aerophilum gen. nov., sp. nov. and Thioalkalimicrobium sibericum sp. nov., and Thioalkalivibrio versutus gen. nov., sp. nov., Thioalkalivibrio nitratis sp.nov., novel and Thioalkalivibrio denitrificancs sp. nov., novel obligately alkaliphilic and obligately chemolithoautotrophic sulfur-oxidizing bacteria from soda lakes. International journal of systematic and evolutionary microbiology 140 11321103
2002 Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse. The Journal of neuroscience : the official journal of the Society for Neuroscience 139 11784792
2019 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nature cell biology 137 31871319
2008 Dethiobacter alkaliphilus gen. nov. sp. nov., and Desulfurivibrio alkaliphilus gen. nov. sp. nov.: two novel representatives of reductive sulfur cycle from soda lakes. Extremophiles : life under extreme conditions 134 18317684
2010 Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Molecular psychiatry 127 21116278
2019 The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Molecular cell 124 30639242
2021 Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nature genetics 116 34857952
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
2021 Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 113 34349018
2004 Subdoligranulum variabile gen. nov., sp. nov. from human feces. Anaerobe 108 16701519
2018 Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Molecular & cellular proteomics : MCP 101 30021884
2013 Fusicatenibacter saccharivorans gen. nov., sp. nov., isolated from human faeces. International journal of systematic and evolutionary microbiology 93 23625266
2011 Sphaerochaeta globosa gen. nov., sp. nov. and Sphaerochaeta pleomorpha sp. nov., free-living, spherical spirochaetes. International journal of systematic and evolutionary microbiology 88 21398503
2006 Ethanoligenens harbinense gen. nov., sp. nov., isolated from molasses wastewater. International journal of systematic and evolutionary microbiology 74 16585689
2008 Asaccharobacter celatus gen. nov., sp. nov., isolated from rat caecum. International journal of systematic and evolutionary microbiology 71 18450720
2007 Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. The Journal of biological chemistry 62 17500060
1996 Emended description of Buttiauxella agrestis with recognition of six new species of Buttiauxella and two new species of Kluyvera: Buttiauxella ferragutiae sp. nov., Buttiauxella gaviniae sp. nov., Buttiauxella brennerae sp. nov., Buttiauxella izardii sp. nov., Buttiauxella noackiae sp. nov., Buttiauxella warmboldiae sp. nov., Kluyvera cochleae sp. nov., and Kluyvera georgiana sp. nov. International journal of systematic bacteriology 57 11534554
1996 Regulation of nov by WT1: a potential role for nov in nephrogenesis. Oncogene 56 8622864
1983 Brevibacterium casei sp. nov. and Brevibacterium epidermidis sp. nov. Systematic and applied microbiology 52 23194737
2007 Undibacterium pigrum gen. nov., sp. nov., isolated from drinking water. International journal of systematic and evolutionary microbiology 51 17625185
2004 Anoxybacillus ayderensis sp. nov. and Anoxybacillus kestanbolensis sp. nov. International journal of systematic and evolutionary microbiology 48 15388701
2003 Amycolatopsis kentuckyensis sp. nov., Amycolatopsis lexingtonensis sp. nov. and Amycolatopsis pretoriensis sp. nov., isolated from equine placentas. International journal of systematic and evolutionary microbiology 48 13130055
1991 Bifidobacterium ruminantium sp. nov. and Bifidobacterium merycicum sp. nov. from the rumens of cattle. International journal of systematic bacteriology 47 1995032
2007 Thalassospira xiamenensis sp. nov. and Thalassospira profundimaris sp. nov. International journal of systematic and evolutionary microbiology 46 17267971
1997 Methylosulfonomonas methylovora gen. nov., sp. nov., and Marinosulfonomonas methylotropha gen. nov., sp. nov.: novel methylotrophs able to grow on methanesulfonic acid. Archives of microbiology 46 9000341
2002 A role for CCN3 (NOV) in calcium signalling. Molecular pathology : MP 43 12147716
2000 Actinoalloteichus cyanogriseus gen. nov., sp. nov. International journal of systematic and evolutionary microbiology 35 10939647
2006 Dokdonella koreensis gen. nov., sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 34 16403879
2021 Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies. Genetics in medicine : official journal of the American College of Medical Genetics 33 34054129
2012 Description of Fimbriimonas ginsengisoli gen. nov., sp. nov. within the Fimbriimonadia class nov., of the phylum Armatimonadetes. Antonie van Leeuwenhoek 33 22527625
2012 Sphingomonas ginsengisoli sp. nov. and Sphingomonas sediminicola sp. nov. International journal of systematic and evolutionary microbiology 32 22505600
2008 Arthrobacter oryzae sp. nov. and Arthrobacter humicola sp. nov. International journal of systematic and evolutionary microbiology 32 18175682
2005 Agromyces salentinus sp. nov. and Agromyces neolithicus sp. nov. International journal of systematic and evolutionary microbiology 31 15653869
2005 Lactobacillus acidifarinae sp. nov. and Lactobacillus zymae sp. nov., from wheat sourdoughs. International journal of systematic and evolutionary microbiology 30 15774633
2009 Chelativorans multitrophicus gen. nov., sp. nov. and Chelativorans oligotrophicus sp. nov., aerobic EDTA-degrading bacteria. International journal of systematic and evolutionary microbiology 29 19666787
2003 Psychrophilic Planococcus maitriensis sp.nov. from Antarctica. Systematic and applied microbiology 29 14666977
2015 Bacillus zhangzhouensis sp. nov. and Bacillus australimaris sp. nov. International journal of systematic and evolutionary microbiology 28 26705002
2005 Dokdonia donghaensis gen. nov., sp. nov., isolated from sea water. International journal of systematic and evolutionary microbiology 28 16280490
2020 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. PloS one 27 32692763
2020 CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage. International journal of molecular sciences 27 33066270
2007 Parapedobacter koreensis gen. nov., sp. nov. International journal of systematic and evolutionary microbiology 27 17551054
1988 Bilophococcus magnetotacticus gen. nov. sp. nov., a motile, magnetic coccus. Antonie van Leeuwenhoek 25 3232969
2022 RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway. Oncogene 24 35508542
2019 MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway. EBioMedicine 24 31383552
2015 Rhabdobacter roseus gen. nov., sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 24 26508300
2012 Mangrovimonas yunxiaonensis gen. nov., sp. nov., isolated from mangrove sediment. International journal of systematic and evolutionary microbiology 24 23041641
2018 A polyphasic approach leads to seven new species of the cellulose-decomposing genus Sorangium, Sorangium ambruticinum sp. nov., Sorangium arenae sp. nov., Sorangium bulgaricum sp. nov., Sorangium dawidii sp. nov., Sorangium kenyense sp. nov., Sorangium orientale sp. nov. and Sorangium reichenbachii sp. nov. International journal of systematic and evolutionary microbiology 23 30234476
2019 PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons. Development (Cambridge, England) 22 31690636
2009 Description of Leifsonia kafniensis sp. nov. and Leifsonia antarctica sp. nov. International journal of systematic and evolutionary microbiology 22 19502314
2009 Rudaea cellulosilytica gen. nov., sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 22 19620378
2006 Meganema perideroedes gen. nov., sp. nov., a filamentous alphaproteobacterium from activated sludge. International journal of systematic and evolutionary microbiology 22 16902022
2005 Pseudoxanthomonas koreensis sp. nov. and Pseudoxanthomonas daejeonensis sp. nov. International journal of systematic and evolutionary microbiology 22 15774663
2022 Nanobdella aerobiophila gen. nov., sp. nov., a thermoacidophilic, obligate ectosymbiotic archaeon, and proposal of Nanobdellaceae fam. nov., Nanobdellales ord. nov. and Nanobdellia class. nov. International journal of systematic and evolutionary microbiology 21 35993221
2016 Fermentibacillus polygoni gen. nov., sp. nov., an alkaliphile that reduces indigo dye. International journal of systematic and evolutionary microbiology 21 26971318
2006 Enterococcus silesiacus sp. nov. and Enterococcus termitis sp. nov. International journal of systematic and evolutionary microbiology 21 16514030
2018 Rubneribacter badeniensis gen. nov., sp. nov. and Enteroscipio rubneri gen. nov., sp. nov., new members of the Eggerthellaceae isolated from human faeces. International journal of systematic and evolutionary microbiology 20 29537365
2018 Prevalence and associated phenotypes of PLXNA1 variants in normosmic and anosmic idiopathic hypogonadotropic hypogonadism. Clinical genetics 20 30467832
2015 Pseudooceanicola atlanticus gen. nov. sp. nov., isolated from surface seawater of the Atlantic Ocean and reclassification of Oceanicola batsensis, Oceanicola marinus, Oceanicola nitratireducens, Oceanicola nanhaiensis, Oceanicola antarcticus and Oceanicola flagellatus, as Pseudooceanicola batsensis comb. nov., Pseudooceanicola marinus comb. nov., Pseudooceanicola nitratireducens comb. nov., Pseudooceanicola nanhaiensis comb. nov., Pseudooceanicola antarcticus comb. nov., and Pseudooceanicola flagellatus comb. nov. Antonie van Leeuwenhoek 20 25663028
2017 Description of Rhodobacter azollae sp. nov. and Rhodobacter lacus sp. nov. International journal of systematic and evolutionary microbiology 18 28829020
2015 Reclassification of Actinobacillus muris as Muribacter muris gen. nov., comb. nov. International journal of systematic and evolutionary microbiology 18 26296776
2015 Chujaibacter soli gen. nov., sp. nov., isolated from soil. Journal of microbiology (Seoul, Korea) 18 26310302
2012 Cellulomonas soli sp. nov. and Cellulomonas oligotrophica sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 18 22328604
2007 Humicoccus flavidus gen. nov., sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 18 17220441
2006 Goodfellowia gen. nov., a new genus of the Pseudonocardineae related to Actinoalloteichus, containing Goodfellowia coeruleoviolacea gen. nov., comb. nov. International journal of systematic and evolutionary microbiology 18 16738092
2005 Oryzihumus leptocrescens gen. nov., sp. nov. International journal of systematic and evolutionary microbiology 18 16280526
2016 Harryflintia acetispora gen. nov., sp. nov., isolated from chicken caecum. International journal of systematic and evolutionary microbiology 17 27432404
2007 Nonomuraea bangladeshensis sp. nov. and Nonomuraea coxensis sp. nov. International journal of systematic and evolutionary microbiology 17 17625184
2022 Apilactobacillus apisilvae sp. nov., Nicolia spurrieriana gen. nov. sp. nov., Bombilactobacillus folatiphilus sp. nov. and Bombilactobacillus thymidiniphilus sp. nov., four new lactic acid bacterial isolates from stingless bees Tetragonula carbonaria and Austroplebeia australis. International journal of systematic and evolutionary microbiology 16 36094463
2010 Nocardioides ultimimeridianus sp. nov. and Nocardioides maradonensis sp. nov., isolated from rhizosphere soil. International journal of systematic and evolutionary microbiology 16 20833879
2008 Actinomadura bangladeshensis sp. nov. and Actinomadura chokoriensis sp. nov. International journal of systematic and evolutionary microbiology 16 18599711
2007 Metascardovia criceti Gen. Nov., Sp. Nov., from hamster dental plaque. Microbiology and immunology 16 17704637
2019 Faecalibacillus intestinalis gen. nov., sp. nov. and Faecalibacillus faecis sp. nov., isolated from human faeces. International journal of systematic and evolutionary microbiology 15 31099736
2016 Dinghuibacter silviterrae gen. nov., sp. nov., isolated from forest soil. International journal of systematic and evolutionary microbiology 15 26828023
2011 Pseudahrensia aquimaris gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 15 22021581
2010 Allobacillus halotolerans gen. nov., sp. nov. isolated from shrimp paste. International journal of systematic and evolutionary microbiology 15 20511460
2010 Allocatelliglobosispora scoriae gen. nov., sp. nov., isolated from volcanic ash. International journal of systematic and evolutionary microbiology 14 20207801
2010 Paraperlucidibaca baekdonensis gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 14 20601489
2008 Saxeibacter lacteus gen. nov., sp. nov., an actinobacterium isolated from rock. International journal of systematic and evolutionary microbiology 14 18398192
2006 Ancylobacter polymorphus sp. nov. and Ancylobacter vacuolatus sp. nov. International journal of systematic and evolutionary microbiology 14 16738088
2015 Pontivivens insulae gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 13 26012580
2014 Paradevosia shaoguanensis gen. nov., sp. nov., isolated from a coking wastewater. Current microbiology 13 25234654
2023 Amygdalobacter indicium gen. nov., sp. nov., and Amygdalobacter nucleatus sp. nov., gen. nov.: novel bacteria from the family Oscillospiraceae isolated from the female genital tract. International journal of systematic and evolutionary microbiology 12 37787404
2014 Haplomyxa saranae gen. nov. et sp. nov., a new naked freshwater foraminifer. Protist 12 24810177
2014 Halopolyspora alba gen. nov., sp. nov., isolated from sediment. International journal of systematic and evolutionary microbiology 12 24860112
2024 PLXNA1 confers enzalutamide resistance in prostate cancer via AKT signaling pathway. Neoplasia (New York, N.Y.) 11 39226661
2024 PlexinA1 (PLXNA1) as a novel scaffold protein for the engineering of extracellular vesicles. Journal of extracellular vesicles 11 39508411
2016 Compostibacter hankyongensis gen. nov.,  sp. nov., isolated from compost. International journal of systematic and evolutionary microbiology 11 27335062
2012 Thermovum composti gen. nov., sp. nov., an alphaproteobacterium from compost. International journal of systematic and evolutionary microbiology 11 22307514
2010 Actinophytocola timorensis sp. nov. and Actinophytocola corallina sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 11 20495034
2010 Pontirhabdus pectinivorans gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 11 21097642
2007 Humihabitans oryzae gen. nov., sp. nov. International journal of systematic and evolutionary microbiology 11 17766892
2022 Description of a moderately acidotolerant and aerotolerant anaerobic bacterium Acidilutibacter cellobiosedens gen. nov., sp. nov. within the family Acidilutibacteraceae fam. nov., and proposal of Sporanaerobacteraceae fam. nov. and Tepidimicrobiaceae fam. nov. Systematic and applied microbiology 10 36375421
2021 Neuropathological Findings in a Case of Parkinsonism and Developmental Delay Associated with a Monoallelic Variant in PLXNA1. Movement disorders : official journal of the Movement Disorder Society 10 34415653
2020 Fluviispira multicolorata gen. nov., sp. nov. and Silvanigrella paludirubra sp. nov., isolated from freshwater habitats. International journal of systematic and evolutionary microbiology 10 31904321
2017 Agarilytica rhodophyticola gen. nov., sp. nov., isolated from Gracilaria blodgettii. International journal of systematic and evolutionary microbiology 10 28879838
2015 Parasediminibacterium paludis gen. nov., sp. nov., isolated from wetland. International journal of systematic and evolutionary microbiology 10 26514371
2015 Marivivens donghaensis gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 10 26582231
2012 Lactobacillus pasteurii sp. nov. and Lactobacillus hominis sp. nov. International journal of systematic and evolutionary microbiology 10 22328611
2012 Neoscardovia arbecensis gen. nov., sp. nov., isolated from porcine slurries. Systematic and applied microbiology 10 22824582
2010 Pseudonocardia mongoliensis sp. nov. and Pseudonocardia khuvsgulensis sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 10 20418406
2018 Xylanibacillus composti gen. nov., sp. nov., isolated from compost. International journal of systematic and evolutionary microbiology 9 29458465
2017 Chengkuizengella sediminis gen. nov. sp. nov., isolated from sediment. International journal of systematic and evolutionary microbiology 9 28786783
2015 Fluviicoccus keumensis gen. nov., sp. nov., isolated from freshwater. International journal of systematic and evolutionary microbiology 9 26498187
2010 Scopulibacillus darangshiensis gen. nov., sp. nov., isolated from rock. Journal of microbiology (Seoul, Korea) 9 20127464
2008 Catenulispora subtropica sp. nov. and Catenulispora yoronensis sp. nov. International journal of systematic and evolutionary microbiology 9 18599693