Affinage

NRP1

Protein kinase C-binding protein NELL1 · UniProt Q92832

Length
810 aa
Mass
89.6 kDa
Annotated
2026-06-10
100 papers in source corpus 36 papers cited in narrative 36 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 10/10 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NRP1 is a multifunctional transmembrane co-receptor that integrates VEGF and class-3 semaphorin cues to control endothelial behavior during angiogenesis and to guide neuronal and other developmental processes (PMID:21653826, PMID:17428830). Its b1 domain residues Y297 and D320 mediate high-affinity VEGF binding and assembly of the NRP1-VEGFR2 complex, driving FAK phosphorylation and endothelial migration; binding-deficient mutants act dominant-negatively by heterodimerizing with wild-type NRP1 and NRP2 (PMID:21653826). NRP1 self-associates and partners with VEGFR2 even before ligand engagement, and these interactions are reorganized by VEGF-A, with endoglin further bridging a tripartite NRP1/VEGFR2/ENG complex required for optimal VEGFR2 and Erk1/2 phosphorylation and sprouting (PMID:38242992, PMID:29630862). NRP1 functions cell-autonomously in endothelial tip cells to promote angiogenesis (PMID:23315162), and acts as the pivot of endothelial heterogeneity in the Dll4/Notch loop by limiting Smad2/3 activation through ALK1/ALK5 to suppress the stalk-cell phenotype (PMID:26081042). The spatial geometry of NRP1 presentation tunes signaling output: in cis VEGF drives rapid VEGFR2/NRP1 co-internalization, whereas NRP1 in trans arrests VEGFR2 endocytosis and reshapes downstream PLCγ/ERK kinetics (PMID:24656741). VEGF165-induced vascular permeability requires the NRP1 cytoplasmic domain, which activates an ABL→SRC-family kinase cascade within the receptor complex (PMID:28289053). NRP1 output is further controlled by ADAM9/10-mediated cleavage that generates inhibitory C-terminal fragments (PMID:29880492). Beyond vasculature, SEMA3A signaling through NRP1 directs sympathetic neuron positioning and axon guidance (PMID:22790009) and confers fast-twitch myofiber specificity to muscle progenitors (PMID:31474563), and NRP1 serves as a co-receptor with VLDLR for Reelin to control cortical dendritic development (PMID:33009002). NRP1 also acts as an entry receptor for mammalian orthoreovirus through multivalent capsid engagement of its extracellular domains, contributing to viral dissemination and neurovirulence (PMID:38729153). A disease-linked gain-of-function interaction occurs in Charcot-Marie-Tooth type 2N, where CMT2N-causing AlaRS mutations loosen the aminoacylation domain and create an aberrant interaction with the NRP1 b1b2 domains not seen with wild-type AlaRS (PMID:33753480).

Mechanistic history

Synthesis pass · year-by-year structured walk · 24 steps
  1. 2007 High

    Resolved whether SEMA3A and VEGF compete at NRP1 to coordinate neurovascular patterning, establishing that VEGF164—not SEMA3A—drives NRP1-dependent angiogenesis while SEMA3A patterns axons independently.

    Evidence Sema3a and Vegf isoform mouse knockouts with genetic interaction analysis of vessel and axon patterning

    PMID:17428830

    Open questions at the time
    • Does not define how distinct ligands engage the same receptor without competition
    • Mechanism of NRP1 ligand selectivity not resolved
  2. 2011 High

    Mapped the molecular determinants of VEGF binding to NRP1, showing b1-domain residues Y297/D320 are essential for VEGFR2 complex formation and downstream FAK signaling, and that non-binding mutants act dominant-negatively.

    Evidence Site-directed mutagenesis, VEGF binding/Co-IP/phosphorylation and migration assays in HUVECs

    PMID:21653826

    Open questions at the time
    • Does not establish in vivo requirement of these residues
    • Stoichiometry of the NRP1-VEGFR2 complex unresolved
  3. 2011 High

    Extended NRP1 function beyond endothelium by showing an autocrine VEGF/NRP1 loop sustains cancer stem-cell self-renewal and tumor initiation in skin.

    Evidence Conditional Nrp1 knockout in tumor epithelium with CSC self-renewal assays and VEGF gain/loss

    PMID:22012397

    Open questions at the time
    • Cytoplasmic effectors in epithelial cells not defined here
    • Relationship to VEGFR2 in epithelium unclear
  4. 2012 High

    Defined cell-autonomous SEMA3A/NRP1 roles in sympathetic nervous system development, linking NRP1 loss to cardiac innervation defects and bradycardia.

    Evidence Lineage-specific conditional Nrp1 knockouts and Sema3a/NRP compound mutants with cardiac phenotyping

    PMID:22790009

    Open questions at the time
    • Downstream plexin partners not dissected
    • Cytoplasmic signaling for neuronal positioning unresolved
  5. 2014 High

    Established NRP1 as a cell-autonomous tip-cell determinant in brain angiogenesis and showed the spatial context (cis vs trans) of NRP1 dictates VEGFR2 trafficking and signaling output.

    Evidence Endothelial conditional knockout with mosaic analysis; co-culture cis/trans systems with internalization and phosphorylation time courses and tumor models

    PMID:23315162 PMID:24656741

    Open questions at the time
    • Molecular basis of trans-mediated endocytic arrest not fully defined
    • How cis/trans balance is set in vivo unclear
  6. 2014 Medium

    Broadened the active NRP1 ligand repertoire in the nervous system by showing VEGF189, in addition to VEGF165, binds NRP1 and supports neuronal migration, survival, and axon guidance.

    Evidence In situ ligand binding, VEGF isoform knock-in mice, in vitro neuronal assays

    PMID:25519242

    Open questions at the time
    • Receptor complex composition for VEGF189 not defined
    • Single-lab functional characterization
  7. 2015 High

    Positioned NRP1 as the pivot of endothelial tip/stalk heterogeneity by showing it suppresses stalk-cell behavior via ALK1/ALK5-Smad2/3 inhibition downstream of Notch.

    Evidence Genetic epistasis in zebrafish and mouse, endothelial Nrp1 knockout, Smad2/3 phosphorylation and ALK inhibitor experiments

    PMID:26081042

    Open questions at the time
    • Direct biochemical link between NRP1 and ALK receptors not shown
    • How Notch transcriptionally controls NRP1 not resolved
  8. 2015 Medium

    Identified cytoplasmic-domain-dependent GIPC1-Syx-RhoA signaling as an NRP1 output controlling cancer proliferation through p27 degradation.

    Evidence Co-IP, RhoA activity assays, NRP1 cytoplasmic deletion mutants, RhoA/ROCK inhibition in cancer cells

    PMID:26209534

    Open questions at the time
    • Single-lab pathway without in vivo validation here
    • Receptor partner upstream of GIPC1-Syx in this context not defined
  9. 2015 Medium

    Revealed NRP1 stabilizes and amplifies non-VEGF receptors, prolonging DDR2 half-life and enhancing ERK1/2/Runx2 signaling to drive osteoblast differentiation.

    Evidence Co-localization, Co-IP, protein half-life and osteogenic differentiation assays

    PMID:25924845

    Open questions at the time
    • Mechanism of DDR2 stabilization unknown
    • Single-lab finding without in vivo confirmation
  10. 2016 Medium

    Demonstrated an immunoregulatory role in which VEGF-dependent NRP1 directly engages TLR4 to suppress dendritic cell maturation via ERK/NF-κB inhibition.

    Evidence Conditional NRP1-knockout BMDCs, NRP1-TLR4 Co-IP, signaling and surface-marker readouts

    PMID:27815442

    Open questions at the time
    • Structural basis of NRP1-TLR4 interaction unknown
    • Single-lab Co-IP without reciprocal structural validation
  11. 2017 High

    Defined the cytoplasmic-domain mechanism for VEGF165-induced vascular permeability, establishing an NRP1-cytoplasmic-domain→ABL→SRC-family-kinase cascade independent of GIPC1.

    Evidence NRP1 cytoplasmic-domain knock-in mice, Miles assay, ABL/SFK kinase assays, choroidal neovascularization model

    PMID:28289053

    Open questions at the time
    • How ABL is recruited to the cytoplasmic domain not defined
    • Direct NCD-ABL binding interface unresolved
  12. 2018 High

    Identified a negative-feedback mechanism whereby VEGF drives ADAM9/10 cleavage of NRP1, producing inhibitory C-terminal fragments that suppress VEGFR2 signaling and angiogenesis.

    Evidence ADAM9/10 knockdown, ADAM10 inhibitor, C-terminal fragment overexpression, sprouting and angiogenesis assays

    PMID:29880492

    Open questions at the time
    • In vivo physiological relevance of cleavage not established
    • Cleavage site and regulation incompletely defined
  13. 2018 Medium

    Characterized NRP1/VEGFR2 plasma-membrane organization, showing pre-ligand homo- and hetero-interactions modulated by VEGFA.

    Evidence Quantitative FRET in plasma membrane with VEGFA addition/removal

    PMID:29630862

    Open questions at the time
    • Functional consequence of pre-ligand assembly not measured
    • Single biophysical method
  14. 2018 Medium

    Extended NRP1 cytoplasmic GIPC1 signaling to integrin- and YAP-dependent cancer stem-cell programs, linking NRP1/GIPC1/integrin-FAK/Src to YAP1/ΔNp63α and RhoA-p38 outputs.

    Evidence Co-IP of NRP1-GIPC1-integrin complexes, kinase assays, rescue experiments, xenograft models

    PMID:29755126 PMID:30456845

    Open questions at the time
    • Same-lab findings without independent replication
    • Direct NRP1-integrin contact interface not mapped
  15. 2020 High

    Established NRP1 as a Reelin co-receptor that complexes with VLDLR to augment Reelin signaling and control cortical dendritic development.

    Evidence NRP1-VLDLR Co-IP, in utero electroporation knockdown, Dab1 and dendritic morphology assays, Reelin CTR mutant binding

    PMID:33009002

    Open questions at the time
    • Structural basis of Reelin CTR-NRP1 binding not solved
    • Single-lab characterization
  16. 2020 High

    Defined an epidermal cell-autonomous VEGFA/NRP1/FLT1 axis driving psoriasis, with Fosl1 as a downstream effector and therapeutic responsiveness to anti-NRP1 antibody.

    Evidence Keratinocyte-specific Nrp1 knockout, psoriasis models, anti-Nrp1 antibody, ATAC-seq/RNA-seq

    PMID:31934626

    Open questions at the time
    • Cytoplasmic signaling linking NRP1 to Fosl1 not dissected
    • Receptor partner in keratinocytes (FLT1 vs VEGFR2) roles incomplete
  17. 2021 High

    Connected NRP1 to a Mendelian disease by showing CMT2N-causing AlaRS mutations structurally loosen the aminoacylation domain to enable an aberrant gain-of-function interaction with the NRP1 b1b2 domains.

    Evidence X-ray crystallography, SAXS, HDX, switchSENSE, Co-IP in patient samples

    PMID:33753480

    Open questions at the time
    • Downstream cellular consequence of aberrant binding on NRP1 signaling not defined
    • Causal link to neuropathy phenotype mechanistically incomplete
  18. 2021 High

    Established SEMA3A/NRP1 as a chemorepellent system specifying fast-twitch myofiber identity by restricting Tw2+/Nrp1+ progenitor fusion.

    Evidence RNA-seq, stripe migration and chimeric fusion assays, Sema3a transgenic mice

    PMID:31474563

    Open questions at the time
    • Plexin co-receptor identity in muscle not defined
    • Downstream cytoskeletal signaling not resolved
  19. 2021 Medium

    Implicated NRP1 in immune and tumor microenvironment functions, promoting ILC3 IL-17A via NF-κB and serving as a galectin-1 binding partner expanding MDSCs.

    Evidence NRP1 conditional knockout and pharmacological inhibition (ILC3/colitis); flow-cytometry galectin-1 binding and blockade assays (MDSC)

    PMID:33771821 PMID:39741194

    Open questions at the time
    • Direct NRP1 ligand driving ILC3 NF-κB not identified
    • Single-lab characterizations in each immune context
  20. 2023 Medium

    Expanded the NRP1 receptor-partner network in cancer to EGFR, with extracellular b1/b2 engagement driving AKT activation, and identified transcriptional control of NRP1 by HIF1α.

    Evidence NRP1-EGFR Co-IP, domain deletions, phosphorylation assays, ChIP of HIF1α on the NRP1 promoter, xenograft

    PMID:36841806

    Open questions at the time
    • Direct vs indirect NRP1-EGFR contact not fully resolved
    • Single-lab finding
  21. 2023 Medium

    Identified post-translational and mechanotransductive control of NRP1, with USP9X deubiquitinating and stabilizing NRP1 in fibrosis, and NRP1 binding YAP to relay mechanical stress via the LATS1/YAP axis.

    Evidence Co-IP/ubiquitination assays and CCl4 fibrosis model (USP9X); NRP1-YAP Co-IP, compression model and rat scar model (mechanotransduction)

    PMID:36653359 PMID:37704618

    Open questions at the time
    • USP9X ubiquitin-site specificity on NRP1 not mapped
    • Single-lab Co-IPs without reciprocal structural validation
  22. 2024 Medium

    Refined the endothelial VEGF receptor module by showing endoglin bridges a tripartite NRP1/VEGFR2/ENG complex needed for optimal signaling, and quantified distinct receptor trafficking with NRP1 predominantly surface-retained.

    Evidence FRAP co-mobility assays and ENG/NRP1 gain/loss with sprouting (ENG); quantitative trafficking measurements with computational modeling (HUVEC)

    PMID:38242992 PMID:38324585

    Open questions at the time
    • Structural arrangement of the tripartite complex unknown
    • Single-lab quantitative datasets
  23. 2024 High

    Established NRP1 as an entry receptor for mammalian orthoreovirus through multivalent capsid engagement of its extracellular domains, contributing to dissemination and neurovirulence.

    Evidence Affinity binding measurements, capsid mutant mapping, in vivo dissemination and neurovirulence assays

    PMID:38729153

    Open questions at the time
    • Whether viral entry co-opts native NRP1 signaling unknown
    • Post-binding internalization route not defined
  24. 2024 Medium

    Linked NRP1 to neuronal gene-regulatory control of memory, identifying it as a Dnmt3a1-dependent transcriptional target required for long-term spatial and contextual memory.

    Evidence Dnmt3a1 knockout mice, RNA-seq, hippocampal Nrp1 knockdown/overexpression, behavioral and rescue assays

    PMID:38499720

    Open questions at the time
    • NRP1 ligand/partner mediating memory function not identified
    • Mechanism downstream of NRP1 in neurons unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NRP1's single short cytoplasmic domain selectively assembles distinct signaling complexes (VEGFR2, plexins, VLDLR, TLR4, EGFR, integrins, endoglin) to produce context-specific outputs remains unresolved.
  • No unifying structural model of multi-partner complex assembly
  • Rules governing cis vs trans and ligand-specific complex choice undefined
  • Integration of co-receptor signaling across tissues not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0048018 receptor ligand activity 3 GO:0060089 molecular transducer activity 3 GO:0001618 virus receptor activity 1
Localization
GO:0005886 plasma membrane 5
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3
Partners
EGFRENGGIPC1NRP2TLR4USP9XVEGFR2VLDLR
Complex memberships
NRP1-VEGFR2 complexNRP1-VLDLR Reelin co-receptor complexNRP1/VEGFR2/endoglin complexSEMA3A-PlexinA1-NRP1 complex

Evidence

Reading pass · 36 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 VEGF binding to NRP1 requires residues Y297 and D320 in the b1 domain; mutations at these sites abolish high-affinity VEGF binding, disrupt NRP1-VEGFR2 (KDR) complex formation, reduce FAK Tyr407 phosphorylation, and impair endothelial cell migration and angiogenesis. NRP1 non-binding mutants can act dominantly negative by heterodimerizing with wild-type NRP1 and NRP2. Site-directed mutagenesis, VEGF binding assays, co-immunoprecipitation, phosphorylation assays, migration assays, coculture angiogenesis model, overexpression in HUVECs Molecular biology of the cell High 21653826
2014 NRP1 promotes brain angiogenesis cell-autonomously in endothelium and specifically in tip cells. Endothelial NRP1-expressing cells preferentially attain the tip cell position over NRP1-negative cells in chimeric vessel sprouts. Neural progenitor- and macrophage-derived NRP1 are dispensable for this process. Conditional endothelial-specific Nrp1 knockout, genetic mosaic analysis in chimeric mice, in vivo brain vessel imaging Blood High 23315162
2015 NRP1 suppresses the stalk-cell phenotype during sprouting angiogenesis by limiting Smad2/3 activation through ALK1 and ALK5 (TGF-β/BMP receptors). Notch signaling downregulates NRP1, thereby relieving ALK1/ALK5 inhibition and driving stalk-cell behavior. NRP1 levels act as the pivot for endothelial cell heterogeneity in the Dll4/Notch lateral feedback loop. Genetic epistasis in zebrafish and mouse, endothelial-specific NRP1 knockout, Smad2/3 phosphorylation assays, ALK inhibitor experiments Nature communications High 26081042
2014 NRP1 presented in trans (on a different cell than VEGFR2) arrests VEGFR2 endocytosis, prolonging phosphorylation of PLCγ and ERK2 while reducing ERK1 phosphorylation, and suppresses tumor initiation and vascularization. In cis, VEGF induces rapid VEGFR2/NRP1 complex formation and co-internalization. The trans effect requires high-affinity VEGF binding and the NRP1 C-terminal domain. Co-culture cis/trans cell systems, VEGFR2 internalization assays, phosphorylation time courses, NRP1 domain-deletion constructs, mouse fibrosarcoma/melanoma tumor models Developmental cell High 24656741
2017 VEGF165-induced vascular permeability requires both VEGFR2 and NRP1, specifically the VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD). The NCD promotes ABL kinase activation within the receptor complex, which in turn activates VEGFR2-recruited SRC family kinases (SFKs). GIPC1, a known NCD interactor, is not required for this permeability response. In vivo vascular leakage assays (Miles assay), NRP1 cytoplasmic domain knock-in mice, ABL and SFK kinase assays, tissue culture signaling experiments, choroidal neovascularization mouse model The Journal of experimental medicine High 28289053
2007 SEMA3A is required for axon patterning of limb nerves but not for angiogenesis; VEGF164 (not SEMA3A) controls NRP1-dependent angiogenesis in vivo. There is no genetic interaction between SEMA3A and VEGF164 during vasculogenesis, angiogenesis, or limb axon patterning, arguing against ligand competition at NRP1 controlling neurovascular congruence. Mouse knockouts of Sema3a and Vegf isoforms, genetic interaction analysis, in vivo axon and vessel patterning assays Development (Cambridge, England) High 17428830
2011 NRP1 (via an autocrine VEGF loop) promotes cancer stem cell (CSC) stemness and symmetric division in skin papillomas. Conditional deletion of Nrp1 in tumor epithelial cells blocks VEGF's ability to promote cancer stemness and renewal. NRP1 deletion in normal epidermis also prevents skin tumor initiation. Conditional Nrp1 knockout in tumor epithelial cells (mouse model), CSC functional assays (symmetric division, self-renewal), VEGFR2 blockade, VEGF overexpression/deletion Nature High 22012397
2018 VEGF upregulates NRP1 proteolytic cleavage via ADAM9 and ADAM10 metalloproteinases, generating C-terminal NRP1 fragments (lacking ligand-binding A and B regions) that inhibit VEGF-induced VEGFR2 phosphorylation, endothelial cell motility, and angiogenesis. siRNA knockdown of ADAM9/10, pharmacological ADAM10 inhibitor, adenoviral overexpression of NRP1 C-terminal constructs, VEGFR2 phosphorylation assays, aortic ring sprouting assay, coculture angiogenesis model Arteriosclerosis, thrombosis, and vascular biology High 29880492
2015 VEGF-A/NRP1 signaling induces formation of a GIPC1-Syx complex that activates RhoA, leading to degradation of the CDK inhibitor p27 and cancer cell proliferation. The NRP1 cytoplasmic domain is required for this effect. RhoA/ROCK inhibition blocks VEGF-A-induced proliferation. Co-immunoprecipitation (GIPC1-NRP1, GIPC1-Syx), RhoA activity assays, shRNA knockdown, NRP1 cytoplasmic deletion mutants, C3 exoenzyme/Y27632 inhibition, p27 western blot, proliferation assays Biology open Medium 26209534
2018 NRP-1 forms a complex with GIPC1 and α6/β4-integrin to activate FAK/Src signaling, which stabilizes a YAP1/ΔNp63α complex to enhance epidermal cancer stem cell survival, invasion, and angiogenesis. Loss of NRP-1 reduces tumor vascularization and tumor growth. Co-immunoprecipitation (NRP1-GIPC1-integrin), FAK/Src kinase assays, YAP1/ΔNp63α western blot, NRP-1 knockout xenograft model, constitutively active YAP1/ΔNp63α rescue Oncogene Medium 29755126
2018 NRP-1/GIPC1/Syx complex activates RhoA-dependent p38 MAPK signaling to enhance epidermal cancer stem cell spheroid formation, invasion, migration, and angiogenic potential. Pharmacological inhibition of VEGF-A/NRP-1 interaction or RhoA reduces p38 activity and tumor growth. Co-immunoprecipitation, RhoA/p38 kinase assays, NRP1 knockout cells, constitutively active RhoA/p38 rescue, tumor growth assays Molecular carcinogenesis Medium 30456845
2012 SEMA3A signaling through NRP1 has multiple cell-autonomous roles in sympathetic nervous system development, including neuronal cell body positioning, aggregation, and axon guidance during sympathetic chain assembly and heart/aorta innervation. Loss of NRP1 in the sympathetic lineage causes sinus bradycardia, similar to Sema3a-null mice. Lineage-specific conditional Nrp1 knockout (sympathetic vs. vascular), Sema3a and NRP1/NRP2 compound mutant mice, cardiac function assessment Developmental biology High 22790009
2014 VEGF189 can bind NRP1 and promote NRP1-dependent neuronal migration, survival, and axon guidance responses, demonstrating that VEGF189 (in addition to VEGF165) is a biologically active NRP1 ligand in the nervous system. In situ ligand-binding assays, NRP1 mutant mice, in vitro neuronal migration and survival assays, VEGF isoform knock-in mouse models Development (Cambridge, England) Medium 25519242
2020 Reelin's C-terminal region (CTR) binds NRP1, which forms a complex with VLDLR (a canonical Reelin receptor) in superficial neocortical layers. NRP1 acts as a co-receptor for VLDLR, augments Reelin signaling (reducing Dab1 accumulation), and is required for normal dendritic development in superficial-layer neurons. Proteolytic removal of the 6 C-terminal Reelin residues abolishes NRP1 binding. Co-immunoprecipitation (NRP1-VLDLR), in utero electroporation NRP1 knockdown, Dab1 accumulation assays, dendritic morphology analysis, binding studies with Reelin CTR mutants The Journal of neuroscience High 33009002
2021 CMT2N-causing mutations in the aminoacylation domain of AlaRS (including R329H) cause structural loosening of the domain and enable aberrant interaction with the b1b2 domains of NRP1. Wild-type AlaRS does not interact with NRP1. The aberrant AlaRS-NRP1 interaction is confirmed in patient samples. X-ray crystallography, SAXS, hydrogen-deuterium exchange, switchSENSE hydrodynamic measurements, protease digestion, co-immunoprecipitation in patient samples, in vitro binding assays Proceedings of the National Academy of Sciences of the United States of America High 33753480
2016 In endothelium, VEGF requires NRP-1 to inhibit LPS-dependent dendritic cell maturation. NRP-1-deficient BMDCs are completely insensitive to VEGF-mediated suppression of LPS-induced maturation. Mechanistically, NRP-1 directly interacts with TLR4 in the presence of VEGF and suppresses downstream ERK and NF-κB signaling, resulting in inhibition of MHC II, CD40, CD86 expression, and proinflammatory cytokine production. Conditional NRP-1 knockout BMDCs, co-immunoprecipitation (NRP1-TLR4), ERK/NF-κB phosphorylation assays, flow cytometry for surface markers, cytokine ELISAs Journal of immunology Medium 27815442
2020 Conditional deletion of Nrp1 in epidermal keratinocytes inhibits psoriasis mediated by Vegfa overexpression or c-Jun/JunB deletion, demonstrating an epidermal cell-autonomous function of Vegfa/Nrp1/Flt1. Anti-Nrp1 antibody treatment reverses the psoriasis phenotype. Fosl1 was identified as a key downstream transcription factor in the Vegfa/Nrp1 regulatory network. Conditional keratinocyte-specific Nrp1 knockout mice, psoriasis mouse models, anti-Nrp1 antibody treatment, transcriptional and chromatin profiling (ATAC-seq/RNA-seq) Science advances High 31934626
2023 NRP1 interacts with EGFR via its b1/b2 domain (extracellular interaction), leading to EGFR phosphorylation and activation of the AKT signaling pathway to promote prostate cancer cell proliferation and migration. HIF1α binds the NRP1 promoter and regulates its transcriptional activation. Co-immunoprecipitation (NRP1-EGFR), domain deletion constructs, AKT/EGFR phosphorylation western blot, ChIP assay (HIF1α-NRP1 promoter), siRNA knockdown, NRP1 inhibitor (EG01377) treatment, xenograft model Cell death & disease Medium 36841806
2023 USP9X is a deubiquitinating enzyme that stabilizes NRP1 protein. USP9X-mediated NRP1 deubiquitination enhances hepatic stellate cell (HSC) activation, promoting TGF-β1, VEGFA, and PDGF-BB-mediated liver fibrosis. Co-immunoprecipitation, GST pull-down, in vitro and in vivo ubiquitination assays, USP9X knockdown/overexpression, mouse CCl4 liver fibrosis model, immunohistochemistry Cell death & disease Medium 36653359
2024 NRP1 forms stable complexes with endoglin (ENG) and VEGFR2 at the endothelial cell surface; VEGF-A enhances these interactions. ENG augments NRP1/VEGFR2 interactions, suggesting tripartite complex formation bridged by ENG. Optimal VEGF-A-mediated VEGFR2 and Erk1/2 phosphorylation and sprouting require both ENG and NRP1. FRAP-based IgG-mediated immobilization co-mobility assay, overexpression/knockdown of ENG and NRP1 in murine embryonic endothelial cells (MEEC+/+ and MEEC-/-), VEGFR2/Erk1/2 phosphorylation assays, sprouting assays, MEK1/2 inhibitor Communications biology Medium 38242992
2018 NRP1 and VEGFR2 undergo homo- and hetero-interactions in the plasma membrane. NRP1 self-associates (homo-interactions) and interacts with VEGFR2 in the absence of ligand; these interactions are modulated by VEGFA. Quantitative FRET in plasma membrane, VEGFA ligand addition/removal experiments Biochimica et biophysica acta. Biomembranes Medium 29630862
2019 Sema3a-Nrp1 signaling confers fast-twitch myofiber specificity to Twist2+ muscle progenitors. Sema3a is expressed by slow/intermediate myofibers (type I/IIa) but not IIb fibers, acting as a chemorepellent that restricts Tw2+/Nrp1+ progenitors to fuse with type IIb fibers. RNA sequencing, immunofluorescence, stripe migration assays, chimeric cell-cell fusion assays, Sema3a transgenic mouse model Developmental cell High 31474563
2021 MAOA activates SEMA3C in a Twist1-dependent transcriptional manner; SEMA3C then stimulates cMET via autocrine/paracrine interaction with co-activated PlexinA2 and NRP1, facilitating prostate cancer perineural invasion. In vitro PNI assays, orthotopic xenograft model, MAOA inhibitor treatment, SEMA3C/NRP1/PlexinA2 knockdown, cMET phosphorylation assays Oncogene Medium 33420365
2015 Wedelolactone promotes formation of a Sema3A-PlexinA1-NRP1 complex on BMSCs, activating β-catenin nuclear accumulation and osteoblastogenesis. In osteoclastic cells, it induces PlexinA1-NRP1 complex formation while sequestering PlexinA1-DAP12 complex and suppressing PLCγ2 phosphorylation, inhibiting osteoclastogenesis. Co-immunoprecipitation (Sema3A-NRP1-PlexinA1), co-immunoprecipitation (PlexinA1-DAP12), β-catenin nuclear localization immunofluorescence, PLCγ2 phosphorylation western blot, ALP/TRAP activity assays, Sema3A antibody blocking Frontiers in pharmacology Medium 27803667
2015 NRP1 co-localizes with DDR2 at the plasma membrane of differentiating osteoblasts, prolongs DDR2 protein half-life (stabilizes DDR2), and enhances DDR2-induced ERK1/2 and Runx2 phosphorylation to stimulate osteoblast differentiation. NRP1 does not alter DDR2 mRNA transcription. Co-localization immunofluorescence, co-immunoprecipitation (NRP1-DDR2), half-life determination assay, ERK1/2/Runx2 phosphorylation western blot, ALP activity and OCN secretion assays, NRP1 overexpression/siRNA knockdown Cellular physiology and biochemistry Medium 25924845
2024 NRP1 functions as an entry receptor for mammalian orthoreovirus (reovirus), binding with nanomolar affinity through multivalent interactions involving outer-capsid protein σ3 and capsid turret protein λ2 engaging multiple NRP1 extracellular domains. NRP1 contributes to reovirus dissemination and neurovirulence in mice. Receptor identification assays, nanomolar affinity binding measurements, gene-segment exchange capsid mutants, NRP1-binding-deficient capsid mutants, in vivo mouse dissemination and neurovirulence assays Cell host & microbe High 38729153
2023 NRP1 binds YAP (co-immunoprecipitation), and mechanical compression disrupts this binding, releasing YAP to translocate to the nucleus. NRP1 knockdown promotes LATS1 expression and reduces YAP, inhibiting endothelial cell proliferation. NRP1 thus transduces mechanical stress inhibition via the LATS1/YAP axis in hypertrophic scars. Co-immunoprecipitation (NRP1-YAP), NRP1 knockdown, LATS1/pYAP western blot, mechanical compression culture model, rat tail-scar model, bioinformatics screening Cell death discovery Medium 37704618
2018 RNA-binding protein Lin28B directly binds the NRP-1 3'UTR (confirmed by RIP), increasing NRP-1 mRNA stability and expression, which in turn activates Wnt/β-catenin signaling to promote gastric cancer cell stemness. RNA immunoprecipitation (RIP), luciferase reporter assay, mRNA stability assay, Lin28B overexpression/knockdown, Wnt/β-catenin signaling western blot, spheroid formation assays Biomedicine & pharmacotherapy Medium 29787985
2021 NRP1 promotes IL-17A production by intestinal ILC3s in an NF-κB signaling-dependent and cell-intrinsic manner. Genetic NRP1 deficiency reduces ILC3 frequency in the gut and impairs IL-17A production, altering microbiota composition and improving DSS-induced colitis outcomes. NRP1 conditional knockout mice, ILC3 frequency/IL-17A production assays, NF-κB signaling analysis, DSS colitis model, pharmacological NRP1 inhibition (EG00229) Cellular & molecular immunology Medium 39741194
2021 Myeloma-secreted galectin-1 potently interacts with CD304 (NRP1) on monocytic MDSCs, expanding the M-MDSC population and increasing CD304 expression. Blockade of CD304 reduces MDSC migration and reverses MDSC-mediated suppression of melphalan cytotoxicity. High-throughput flow cytometry screening, galectin-1 in vitro treatment of MDSCs, CD304/NRP1 blockade assays, co-culture with myeloma cell lines (high/low galectin-1), cytotoxicity assays Cancer immunology research Medium 33771821
2024 VEGFR1, VEGFR2, and NRP1 show distinct trafficking dynamics in HUVECs: VEGFR1 has faster internalization and recycling rates than VEGFR2, whereas NRP1 is predominantly retained at the cell surface (high surface fraction). These differences in subcellular localization influence VEGF ligand sensing and receptor complex composition. Quantitative trafficking experiments (receptor internalization and recycling rates measured simultaneously for all three receptors on HUVECs), computational modeling PLoS computational biology Medium 38324585
2024 Dnmt3a1 regulates hippocampus-dependent memory via Nrp1 as a downstream target. Dnmt3a1 activity is required for Nrp1 expression in hippocampal neurons, and Nrp1 is required for long-term spatial and contextual memory. NRP1 overexpression does not rescue memory impairments from Dnmt3a2 reduction, indicating isoform-specific regulation. Dnmt3a1-specific knockout mice, RNA sequencing, Nrp1 knockdown and overexpression in hippocampus, behavioral memory tests (spatial object recognition, contextual fear memory), rescue experiments Neuropsychopharmacology Medium 38499720
2024 YAP/TEAD4 binding to the NRP1 promoter is induced by ionizing radiation in NSCLC cells, transcriptionally upregulating NRP1 expression and conferring radioresistance. NRP1 is identified as a direct transcriptional target of the YAP/TEAD4 complex. ChIP assay (TEAD4-NRP1 promoter), YAP dephosphorylation analysis, YAP/TEAD4 inhibition, NRP1 expression rescue experiments, radiation-resistant A549/H1299 cell models Cell death & disease Medium 39187525
2018 CMTM6 physically interacts with NRP1 (co-immunoprecipitation) in oral squamous cell carcinoma cells. NRP1 is required for CMTM6-driven tumorigenesis: NRP1 silencing abrogates CMTM6-induced oncogenic effects, and NRP1 depletion destabilizes CMTM6 protein, suggesting NRP1 protects CMTM6 from degradation. Co-immunoprecipitation (CMTM6-NRP1), gain/loss-of-function experiments, CMTM6 protein stability assay in NRP1-silenced cells American journal of cancer research Low 32642284
2019 NRP1 knockdown in neuroblastoma SK-N-AS cells increases β1 integrin expression and promotes migration and invasion, indicating NRP1 exerts tumor-suppressive effects in neuroblastoma via regulation of β1 integrin levels. NRP1 siRNA knockdown, wound-healing assay, Matrigel invasion assay, β1 integrin western blot, β1 integrin siRNA knockdown International journal of oncology Low 29750423
2020 NRP1 contributes to cancer stem cell stemness and radioresistance in breast cancer through downregulation of Bcl-2 via the m6A methyltransferase WTAP in an m6A-dependent manner. NRP1 siRNA/plasmid transfection, WTAP m6A methylation assay, Bcl-2 western blot, γH2AX immunofluorescence, flow cytometry apoptosis, shRNA-NRP1 xenograft model with radiotherapy Apoptosis Low 36333630

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature 381 22012397
2011 VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation. Molecular biology of the cell 163 21653826
2015 Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nature communications 138 26081042
2013 NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood 132 23315162
2007 Selective requirements for NRP1 ligands during neurovascular patterning. Development (Cambridge, England) 110 17428830
2014 Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development (Cambridge, England) 101 24401374
2007 IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells. Cancer biology & therapy 90 17568185
2014 MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression. PloS one 78 24736504
2021 MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling. Oncogene 76 33420365
2016 NRP1 function and targeting in neurovascular development and eye disease. Progress in retinal and eye research 75 26923176
2014 NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Developmental cell 73 24656741
2012 NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Developmental biology 67 22790009
2021 The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review. Journal of clinical medicine 60 34202613
2020 FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis. Oncogene 58 33262463
2017 VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. The Journal of experimental medicine 56 28289053
2012 MicroRNA-181b and microRNA-9 mediate arsenic-induced angiogenesis via NRP1. Journal of cellular physiology 54 21503876
2018 Differential expression of CD73, CD86 and CD304 in normal vs. leukemic B-cell precursors and their utility as stable minimal residual disease markers in childhood B-cell precursor acute lymphoblastic leukemia. Journal of immunological methods 49 29530508
2018 A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent. Science translational medicine 49 29794061
2020 Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease. Science advances 48 31934626
2016 Role of NRP-1 in VEGF-VEGFR2-Independent Tumorigenesis. Targeted oncology 45 26916409
2019 Synchronous inhibition of mTOR and VEGF/NRP1 axis impedes tumor growth and metastasis in renal cancer. NPJ precision oncology 43 31840081
2016 Wedelolactone Enhances Osteoblastogenesis but Inhibits Osteoclastogenesis through Sema3A/NRP1/PlexinA1 Pathway. Frontiers in pharmacology 43 27803667
2023 NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation. Cell death & disease 42 36841806
2016 VEGF Requires the Receptor NRP-1 To Inhibit Lipopolysaccharide-Dependent Dendritic Cell Maturation. Journal of immunology (Baltimore, Md. : 1950) 42 27815442
2018 VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling. Arteriosclerosis, thrombosis, and vascular biology 41 29880492
2019 Long noncoding RNA OIP5-AS1 promotes the progression of oral squamous cell carcinoma via regulating miR-338-3p/NRP1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 40 31369989
2021 Role of NRP1 in Bladder Cancer Pathogenesis and Progression. Frontiers in oncology 39 34249735
2017 NRP1-positive lung cancer cells possess tumor-initiating properties. Oncology reports 38 29138851
2015 MicroRNA-365 inhibits growth, invasion and metastasis of malignant melanoma by targeting NRP1 expression. Cancer biomarkers : section A of Disease markers 37 26406949
2020 The regulatory mechanism and biological significance of the Snail-miR590-VEGFR-NRP1 axis in the angiogenesis, growth and metastasis of gastric cancer. Cell death & disease 36 32303680
2018 NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival. Oncogene 36 29755126
2022 NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer. Apoptosis : an international journal on programmed cell death 34 36333630
2021 Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity. Clinical epigenetics 34 34635175
2020 miR-128-3p Inhibits NRP1 Expression and Promotes Inflammatory Response to Acute Kidney Injury in Sepsis. Inflammation 34 32500307
2014 VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain. Development (Cambridge, England) 34 25519242
2021 Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis. Cell death & disease 33 33846300
2018 RNA binding protein Lin28B confers gastric cancer cells stemness via directly binding to NRP-1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 33 29787985
2023 USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells. Cell death & disease 31 36653359
2022 tLyp-1: A peptide suitable to target NRP-1 receptor. Bioorganic chemistry 31 36332316
2021 SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems. Journal of medical virology 31 34324210
2020 NRP1 regulates radiation-induced EMT via TGF-β/Smad signaling in lung adenocarcinoma cells. International journal of radiation biology 30 32659143
2019 RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 30 30909144
2015 VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. Biology open 29 26209534
2020 CMTM6 promotes cell proliferation and invasion in oral squamous cell carcinoma by interacting with NRP1. American journal of cancer research 28 32642284
2022 Solasonine Induces Apoptosis and Inhibits Proliferation of Bladder Cancer Cells by Suppressing NRP1 Expression. Journal of oncology 27 35281516
2011 CD304 is preferentially expressed on a subset of B-lineage acute lymphoblastic leukemia and represents a novel marker for minimal residual disease detection by flow cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology 27 22052678
2021 CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS. Proceedings of the National Academy of Sciences of the United States of America 26 33753480
2017 Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 26 28738522
2020 Effects of NRP1 on angiogenesis and vascular maturity in endothelial cells are dependent on the expression of SEMA4D. International journal of molecular medicine 25 32945351
2017 NRP1 Accelerates Odontoblast Differentiation of Dental Pulp Stem Cells Through Classical Wnt/β-Catenin Signaling. Cellular reprogramming 25 28910136
2024 Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1. Journal of nanobiotechnology 24 38347587
2021 Circular RNA circVMA21 ameliorates lipopolysaccharide (LPS)-induced acute kidney injury by targeting the miR-199a-5p/NRP1 axis in sepsis. Biochemical and biophysical research communications 24 33647793
2024 NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting. Communications biology 23 38242992
2018 Interactions between NRP1 and VEGFR2 molecules in the plasma membrane. Biochimica et biophysica acta. Biomembranes 23 29630862
2023 Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation. Journal of medicinal chemistry 22 38093696
2020 Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner. The Journal of neuroscience : the official journal of the Society for Neuroscience 22 33009002
2022 Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation. Pharmaceutical biology 21 36373992
2021 Stress response proteins NRP1 and NRP2 are pro-survival factors that inhibit cell death during ER stress. Plant physiology 21 34618053
2018 NRP-1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survival. Molecular carcinogenesis 21 30456845
2024 Synovial mesenchymal stem cell-derived exosomal miR-485-3p relieves cartilage damage in osteoarthritis by targeting the NRP1-mediated PI3K/Akt pathway: Exosomal miR-485-3p relieves cartilage damage. Heliyon 20 38293485
2019 Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells. Developmental cell 20 31474563
2015 Placental NRP1 and VEGF expression in pre-eclamptic women and in a homocysteine-treated mouse model of pre-eclampsia. European journal of obstetrics, gynecology, and reproductive biology 20 26708340
2022 Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients. Journal of immunology research 19 36157881
2021 Myeloma-Secreted Galectin-1 Potently Interacts with CD304 on Monocytic Myeloid-Derived Suppressor Cells. Cancer immunology research 19 33771821
2020 Circular RNA-ABCB10 suppresses hepatocellular carcinoma progression through upregulating NRP1/ABL2 via sponging miR-340-5p/miR-452-5p. European review for medical and pharmacological sciences 19 32196586
2019 NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition. American journal of physiology. Heart and circulatory physiology 19 30767669
2006 Hormonal regulation and differential expression of neuropilin (NRP)-1 and NRP-2 genes in bovine granulosa cells. Reproduction (Cambridge, England) 19 16514198
2025 NRP1 instructs IL-17-producing ILC3s to drive colitis progression. Cellular & molecular immunology 18 39741194
2020 NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proceedings of the National Academy of Sciences of the United States of America 18 33199628
2022 LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Behavioural brain research 17 35550840
2022 Correlations between Kidney and Heart Function Bioindicators and the Expressions of Toll-Like, ACE2, and NRP-1 Receptors in COVID-19. Vaccines 17 35891270
2021 NRP1 and MMP9 are dual targets of RNA-binding protein QKI5 to alter VEGF-R/ NRP1 signalling in trophoblasts in preeclampsia. Journal of cellular and molecular medicine 17 33942999
2019 Expression of NRP-1 and NRP-2 in Endometrial Cancer. Current pharmaceutical biotechnology 17 30806307
2012 NRP-1/CD304 expression in acute leukemia: a potential marker for minimal residual disease detection in precursor B-cell acute lymphoblastic leukemia. American journal of clinical pathology 17 22180477
2021 An Essential NRP1-Mediated Role for Tagln2 in Gastric Cancer Angiogenesis. Frontiers in oncology 16 34150622
2020 Carboplatin Inhibits the Progression of Retinoblastoma Through IncRNA XIST/miR-200a-3p/NRP1 Axis. Drug design, development and therapy 16 32904674
2018 Neuropilin-1 (NRP-1) upregulated by IL-6/STAT3 signaling contributes to invasion in pancreatic neuroendocrine neoplasms. Human pathology 16 30420046
2015 Nrp1, a Neuronal Regulator, Enhances DDR2-ERK-Runx2 Cascade in Osteoblast Differentiation via Suppression of DDR2 Degradation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 16 25924845
2024 NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits. Cell host & microbe 15 38729153
2018 NRP1 promotes cell migration and invasion and serves as a therapeutic target in nasopharyngeal carcinoma. International journal of clinical and experimental pathology 15 31938358
2015 Neuropilin-1 (NRP-1) and Magnetic Nanoparticles, a Potential Combination for Diagnosis and Therapy of Gliomas. Current pharmaceutical design 15 26377659
2024 Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells. PLoS computational biology 14 38324585
2011 RNA interference targeting NRP-1 inhibits human glioma cell proliferation and enhances cell apoptosis. Molecular medicine reports 14 21842123
2019 MicroRNA-1247 inhibits the viability and metastasis of osteosarcoma cells via targeting NRP1 and mediating Wnt/β-catenin pathway. European review for medical and pharmacological sciences 13 31539113
2014 NRP-1 expression is strongly associated with the progression of pituitary adenomas. Oncology reports 13 25109698
2023 NRP1 regulates autophagy and proliferation of gastric cancer through Wnt/β-catenin signaling pathway. Aging 12 37702613
2020 CD304/neuropilin-1 is a very useful and dependable marker for the measurable residual disease assessment of B-cell precursor acute lymphoblastic leukemia. Cytometry. Part B, Clinical cytometry 12 31944572
2018 NRP1 knockdown promotes the migration and invasion of human neuroblastoma-derived SK‑N‑AS cells via the activation of β1 integrin expression. International journal of oncology 12 29750423
2024 Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 11 38499720
2020 Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP-1 and HER2 expression and converted MCF7 breast cancer subtype. British journal of pharmacology 11 31883395
2020 Autocrine Signaling of NRP1 Ligand Galectin-1 Elicits Resistance to BRAF-Targeted Therapy in Melanoma Cells. Cancers 11 32784465
2024 Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells by Inhibiting NRP-1. Current molecular medicine 10 37533240
2024 Radiation-induced YAP/TEAD4 binding confers non-small cell lung cancer radioresistance via promoting NRP1 transcription. Cell death & disease 10 39187525
2023 NRP1 transduces mechanical stress inhibition via LATS1/YAP in hypertrophic scars. Cell death discovery 10 37704618
2022 Circular RNA circGSE1 promotes angiogenesis in ageing mice by targeting the miR-323-5p/NRP1 axis. Aging 10 35366240
2022 NRP1 inhibition modulates radiosensitivity of medulloblastoma by targeting cancer stem cells. Cancer cell international 10 36457009
2021 The histone chaperone Nrp1 is required for chromatin stability and nuclear division in Tetrahymena thermophila. Epigenetics & chromatin 10 34301312
2024 Preclinical evaluation of 68 Ga-labeled peptide CK2 for PET imaging of NRP-1 expression in vivo. European journal of nuclear medicine and molecular imaging 9 38319321
2020 Preclinical Efficacy and Safety of an Anti-Human VEGFA and Anti-Human NRP1 Dual-Targeting Bispecific Antibody (IDB0076). Biomolecules 9 32560565
2016 Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers. Oncotarget 9 26701889

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