- Length
- 873 aa
- Mass
- 96.1 kDa
- Annotated
- 2026-06-14
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2007 | The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. | The Journal of biological chemistry | 395 | 18039658 |
| 2004 | Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway. | Neuron | 313 | 14715136 |
| 2014 | Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. | Molecular cancer research : MCR | 251 | 24874432 |
| 2011 | Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. | Arteriosclerosis, thrombosis, and vascular biology | 211 | 21273557 |
| 2006 | Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. | Investigative ophthalmology & visual science | 153 | 16384981 |
| 2007 | Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. | Development (Cambridge, England) | 136 | 17913789 |
| 2010 | The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. | The Journal of biological chemistry | 119 | 20427281 |
| 2021 | VLDLR and ApoER2 are receptors for multiple alphaviruses. | Nature | 112 | 34929721 |
| 2011 | Nanoceria inhibit the development and promote the regression of pathologic retinal neovascularization in the Vldlr knockout mouse. | PloS one | 110 | 21364932 |
| 2008 | Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation. | Investigative ophthalmology & visual science | 107 | 18172119 |
| 1994 | Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor. | European journal of biochemistry | 102 | 7925422 |
| 1996 | Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease. | Journal of neuropathology and experimental neurology | 101 | 8786409 |
| 2003 | Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. | Brain research. Molecular brain research | 88 | 12670700 |
| 2003 | Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. | The Journal of comparative neurology | 86 | 12687696 |
| 2013 | Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway. | The Journal of biological chemistry | 82 | 24381170 |
| 2012 | Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia. | The Biochemical journal | 82 | 21970364 |
| 2008 | Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans. | Proceedings of the National Academy of Sciences of the United States of America | 80 | 18326629 |
| 2017 | Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation. | Nature communications | 77 | 29057873 |
| 2017 | The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease. | Journal of lipid research | 75 | 28292942 |
| 2011 | Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. | Investigative ophthalmology & visual science | 75 | 21282584 |
| 2011 | Similarities and differences in structure, expression, and functions of VLDLR and ApoER2. | Molecular neurodegeneration | 75 | 21554715 |
| 2002 | Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice. | Experimental neurology | 72 | 12093079 |
| 2003 | Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. | Brain research. Developmental brain research | 68 | 12586425 |
| 2013 | Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice. | Experimental eye research | 65 | 23978600 |
| 1999 | Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulation. | Atherosclerosis | 65 | 10488949 |
| 2013 | Sustained inhibition of neovascularization in vldlr-/- mice following intravitreal injection of cerium oxide nanoparticles and the role of the ASK1-P38/JNK-NF-κB pathway. | Biomaterials | 62 | 24140045 |
| 2020 | Transcriptomic and proteomic analyses of ovarian follicles reveal the role of VLDLR in chicken follicle selection. | BMC genomics | 56 | 32677893 |
| 2013 | Very low density lipoprotein receptor (VLDLR) expression is a determinant factor in adipose tissue inflammation and adipocyte-macrophage interaction. | The Journal of biological chemistry | 55 | 24293365 |
| 2009 | Mutations in VLDLR as a cause for autosomal recessive cerebellar ataxia with mental retardation (dysequilibrium syndrome). | Journal of child neurology | 54 | 19332571 |
| 2007 | The Pafah1b complex interacts with the reelin receptor VLDLR. | PloS one | 51 | 17330141 |
| 2014 | Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. | The Journal of comparative neurology | 50 | 25308109 |
| 1994 | Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9p24 by fluorescence in situ hybridization. | Genomics | 50 | 8020981 |
| 2011 | miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis. | Development (Cambridge, England) | 47 | 22115756 |
| 2007 | Identification of a nonsense mutation in the very low-density lipoprotein receptor gene (VLDLR) in an Iranian family with dysequilibrium syndrome. | European journal of human genetics : EJHG | 46 | 18043714 |
| 2023 | Structure of Semliki Forest virus in complex with its receptor VLDLR. | Cell | 45 | 37098345 |
| 2014 | Upregulation of hepatic VLDLR via PPARα is required for the triglyceride-lowering effect of fenofibrate. | Journal of lipid research | 43 | 24899625 |
| 2015 | Hepatitis C virus utilizes VLDLR as a novel entry pathway. | Proceedings of the National Academy of Sciences of the United States of America | 40 | 26699506 |
| 2008 | The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum. | PloS one | 40 | 18301736 |
| 2011 | Identification of VLDLR as a novel endothelial cell receptor for fibrin that modulates fibrin-dependent transendothelial migration of leukocytes. | Blood | 39 | 22096238 |
| 2018 | Effects of long noncoding RNA (linc-VLDLR) existing in extracellular vesicles on the occurrence and multidrug resistance of esophageal cancer cells. | Pathology, research and practice | 37 | 30606658 |
| 2008 | The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI. | Journal of lipid research | 36 | 18367731 |
| 2016 | Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model. | PloS one | 33 | 27711217 |
| 2012 | A missense founder mutation in VLDLR is associated with Dysequilibrium Syndrome without quadrupedal locomotion. | BMC medical genetics | 33 | 22973972 |
| 2016 | RELN and VLDLR mutations underlie two distinguishable clinico-radiological phenotypes. | Clinical genetics | 32 | 27000652 |
| 2012 | FE65 as a link between VLDLR and APP to regulate their trafficking and processing. | Molecular neurodegeneration | 32 | 22429478 |
| 2007 | Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. | Schizophrenia research | 32 | 17936586 |
| 2007 | Selective expression of LDLR and VLDLR in myelinating oligodendrocytes. | Developmental dynamics : an official publication of the American Association of Anatomists | 31 | 17685481 |
| 2024 | Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. | Cell | 30 | 38176410 |
| 1998 | Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE. | Neurobiology of aging | 29 | 9562467 |
| 2017 | Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System. | Frontiers in molecular neuroscience | 28 | 28507505 |
| 2002 | Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia. | Schizophrenia research | 28 | 12363388 |
| 1996 | No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians. | Neuroscience letters | 28 | 8761993 |
| 2013 | ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons. | PloS one | 26 | 23976984 |
| 2015 | A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM). | PloS one | 24 | 25668033 |
| 2018 | Erchen Decoction Ameliorates Lipid Metabolism by the Regulation of the Protein CAV-1 and the Receptors VLDLR, LDLR, ABCA1, and SRB1 in a High-Fat Diet Rat Model. | Evidence-based complementary and alternative medicine : eCAM | 23 | 30402126 |
| 2024 | Structural basis for VLDLR recognition by eastern equine encephalitis virus. | Nature communications | 22 | 39095394 |
| 2024 | The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes. | Nature communications | 22 | 39127734 |
| 2015 | Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia. | Molecular therapy : the journal of the American Society of Gene Therapy | 22 | 26670130 |
| 2010 | Novel VLDLR microdeletion identified in two Turkish siblings with pachygyria and pontocerebellar atrophy. | Neurogenetics | 22 | 20082205 |
| 2007 | A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk. | Journal of lipid research | 22 | 18056683 |
| 2024 | The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses. | Cell reports | 21 | 39369384 |
| 2019 | IDOL regulates systemic energy balance through control of neuronal VLDLR expression. | Nature metabolism | 21 | 32072135 |
| 2017 | C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 20 | 28123028 |
| 2007 | The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice. | Neuropharmacology | 20 | 17261317 |
| 2016 | FoxP2 directly regulates the reelin receptor VLDLR developmentally and by singing. | Molecular and cellular neurosciences | 19 | 27105823 |
| 2011 | The role of Vldlr in intraretinal angiogenesis in mice. | Investigative ophthalmology & visual science | 19 | 21757581 |
| 2004 | Genes related to vascular disease (APOE, VLDL-R, DCP-1) and other vascular factors in late-life depression. | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 19 | 15010349 |
| 2013 | Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections. | Neural development | 17 | 23758727 |
| 2009 | A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins. | Brain research | 17 | 19393635 |
| 2020 | VLDLR is not essential for reelin-induced neuronal aggregation but suppresses neuronal invasion into the marginal zone. | Development (Cambridge, England) | 16 | 32540847 |
| 2017 | Decreased expression of VLDLR is inversely correlated with miR-200c in human colorectal cancer. | Molecular carcinogenesis | 16 | 28112443 |
| 2017 | Clusterin signals via ApoER2/VLDLR and induces meiosis of male germ cells. | American journal of translational research | 16 | 28386352 |
| 2022 | VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation. | Cell reports | 14 | 36516764 |
| 2021 | Nodakenin represses obesity and its complications via the inhibition of the VLDLR signalling pathway in vivo and in vitro. | Cell proliferation | 14 | 34165214 |
| 2023 | Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair. | Basic research in cardiology | 13 | 38147128 |
| 2019 | Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes. | Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis | 13 | 30987865 |
| 2018 | Degradation routes of trafficking-defective VLDLR mutants associated with Dysequilibrium syndrome. | Scientific reports | 13 | 29371607 |
| 2011 | Cloning and expression profiling of the VLDLR gene associated with egg performance in duck (Anas platyrhynchos). | Genetics, selection, evolution : GSE | 13 | 21819592 |
| 2024 | Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans. | International journal of molecular sciences | 12 | 38338752 |
| 2022 | MicroRNA-199a-3p regulates proliferation and milk fat synthesis of ovine mammary epithelial cells by targeting VLDLR. | Frontiers in veterinary science | 12 | 35990270 |
| 2013 | Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing. | Experimental cell research | 12 | 23701949 |
| 2005 | Association of polymorphisms in CYP17A1, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men. | Genomics | 12 | 15953542 |
| 2015 | Neurite Mistargeting and Inverse Order of Intraretinal Vascular Plexus Formation Precede Subretinal Vascularization in Vldlr Mutant Mice. | PloS one | 11 | 26177550 |
| 2013 | Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization. | PloS one | 11 | 24058663 |
| 2016 | Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns. | Scientific reports | 10 | 27184477 |
| 2013 | Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons. | Genes to cells : devoted to molecular & cellular mechanisms | 10 | 23506116 |
| 2013 | The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1). | Biochemical and biophysical research communications | 10 | 24076391 |
| 2024 | TGF-β-activated circRYK drives glioblastoma progression by increasing VLDLR mRNA expression and stability in a ceRNA- and RBP-dependent manner. | Journal of experimental & clinical cancer research : CR | 9 | 38454465 |
| 2024 | SIRT1 regulates hepatic vldlr levels. | Cell communication and signaling : CCS | 9 | 38807218 |
| 2021 | Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR. | Drug development research | 9 | 34145621 |
| 2016 | The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production. | Genetics and molecular biology | 9 | 27560838 |
| 1998 | No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese. | Neuroscience letters | 9 | 9502209 |
| 2024 | A sexually dimorphic hepatic cycle of periportal VLDL generation and subsequent pericentral VLDLR-mediated re-uptake. | Nature communications | 8 | 39341814 |
| 2024 | VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier. | Nature communications | 8 | 39715740 |
| 2019 | Enhancer deletion and allelic effects define a regulatory molecular mechanism at the VLDLR cholesterol GWAS locus. | Human molecular genetics | 8 | 30445632 |
| 2020 | Expression and analysis of ESR1, IGF-1, FSH, VLDLR, LRP, LH, PRLR genes in Pekin duck and Black Muscovy duck. | Gene | 7 | 33007371 |
| 2014 | HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr⁻/⁻ mice. | Biochemical and biophysical research communications | 7 | 25446077 |
| 2001 | Single nucleotide polymorphisms of the very low density lipoprotein receptor (VLDLR) gene. | Journal of human genetics | 7 | 11501949 |
| 2022 | [Molecular mechanism of astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | 6 | 35178994 |
| 2011 | ApoER2 and VLDLR in the developing human telencephalon. | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society | 6 | 21601501 |
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