Affinage

DAB1

Disabled homolog 1 · UniProt O75553

Length
588 aa
Mass
63.8 kDa
Annotated
2026-06-09
100 papers in source corpus 35 papers cited in narrative 35 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DAB1 is an intracellular adaptor protein that serves as the central cytoplasmic transducer of Reelin signaling controlling neuronal positioning during brain development (PMID:10959835, PMID:15249135). Its phosphotyrosine-binding (PTB) domain docks to the NPXY motifs of the Reelin receptors VLDLR and ApoER2, and a separable phosphoinositide-binding activity of the same domain mediates membrane recruitment and basal phosphorylation (PMID:16046028, PMID:15249135). Upon Reelin engagement, Src-family kinases (Src/Fyn) phosphorylate DAB1 on tyrosine residues, and this phosphorylation—not merely DAB1 expression—is the essential functional output, since a non-phosphorylatable allele phenocopies the null (PMID:10959835, PMID:17394141). Phosphorylation is partitioned into functionally distinct site pairs: Y198/Y200 license further phosphorylation, Akt activation, and DAB1 downregulation, while Y220/Y232 recruit Crk-family adaptors to activate the C3G→Rap1 cassette (PMID:18981215, PMID:15062102). These arms feed parallel effector pathways—PI3K p85α recruitment driving Akt activation and GSK3β inhibition (PMID:12882964), and CrkL/C3G/Rap1 signaling that controls cadherin function and the Dock1–Rac cassette to stabilize leading processes during glia-independent somal and terminal translocation (PMID:15062102, PMID:15316068, PMID:21315259, PMID:21697392). Phosphorylated DAB1 is then targeted for proteasomal degradation by a Cullin5–SOCS E3 ligase complex, a negative-feedback step that restrains migration: loss of Cul5 or a degradation-resistant DAB1 allele causes excess migration, and this is the sole route by which Cul5 controls layering (PMID:17974915, PMID:20410119). Additional quality-control and turnover ligases—ZSWIM8, which clears misfolded DAB1 via its intrinsically disordered regions, and TRIM40—further set DAB1 abundance (PMID:35989311, PMID:37146559). Beyond neuronal migration, DAB1 functions in synaptic plasticity and hippocampal learning (PMID:24068831), in endothelial Reelin signaling that controls laminin-α4 secretion and blood-brain-barrier properties (PMID:30139844), and binds APP and ApoER2 through its PTB domain to increase their surface levels and shift APP toward α-secretase processing, reducing Aβ (PMID:16951405, PMID:18089558). DAB1 is also activated by ligand systems beyond Reelin—activated protein C via ApoER2 and Netrin-1 via DCC (PMID:19116273, PMID:29590626)—and is co-opted in cancer, where NOTCH-induced DAB1 engages ABL/TRIO/RHO signaling to drive colorectal invasion (PMID:25432929).

Mechanistic history

Synthesis pass · year-by-year structured walk · 32 steps
  1. 2000 High

    Established that tyrosine phosphorylation of DAB1, rather than its mere presence, is the functional readout of Reelin signaling in vivo.

    Evidence Knock-in mouse expressing all-Tyr→Phe DAB1 with neuronal positioning analysis

    PMID:10959835

    Open questions at the time
    • Did not identify which kinase phosphorylates DAB1
    • Did not resolve which individual tyrosines carry distinct functions
  2. 2003 High

    Defined a PI3K/Akt/GSK3β effector arm downstream of Src-dependent DAB1 phosphorylation, linking Reelin to a defined signaling cascade required for cortical plate formation.

    Evidence Reciprocal Co-IP of DAB1 with p85α, Src/PI3K pharmacological inhibition, migration assays, cholesterol depletion

    PMID:12882964

    Open questions at the time
    • Did not map which phosphotyrosines recruit p85α
    • Membrane microdomain dependence left ambiguous
  3. 2004 High

    Identified a parallel CrkL/CrkII→C3G→Rap1 arm engaged through DAB1 phosphotyrosines Y220/Y232, and connected it to Dock1/Rac-dependent migration machinery.

    Evidence MS identification of phospho-DAB1 partners, Co-IP, Rap1 activation assay, site mutagenesis, Drosophila genetic rescue

    PMID:15062102 PMID:15316068

    Open questions at the time
    • Did not establish the in vivo migration phenotype of selective Crk-site loss
    • Relationship between Rap1 and Dock1/Rac arms unresolved
  4. 2004 High

    Demonstrated that high-affinity PTB-domain binding to VLDLR/ApoER2 tails is required specifically for positioning of late-born cortical neurons.

    Evidence DAB1 F158V knock-in mouse, in vitro receptor peptide binding, dose-sensitive neuroanatomical analysis

    PMID:15249135

    Open questions at the time
    • Subtle phenotype only in hemizygotes leaves quantitative receptor-binding threshold unclear
  5. 2004 Medium

    Showed that alternative splicing generates DAB1 isoforms differing in Src-recognition tyrosines, coupling isoform choice to signaling competence.

    Evidence Chick retinal culture transfection, Src activation assays, Y198F mutagenesis

    PMID:15057276

    Open questions at the time
    • Single lab in chick system
    • Splicing regulator not identified at this stage
  6. 2005 High

    Separated PTB-domain phosphoinositide binding (membrane recruitment, basal phosphorylation) from receptor binding (Reelin-stimulated phosphorylation) as distinct mechanistic functions.

    Evidence Point mutations dissecting PTB activities, neuronal phosphorylation assays

    PMID:16046028

    Open questions at the time
    • Physiological balance of the two binding modes in vivo not quantified
  7. 2006 High

    Reconstituted the full Reelin pathway in fibroblasts and showed lipid-raft localization is dispensable for DAB1 phosphorylation, with phospho-DAB1 remaining receptor-bound.

    Evidence Heterologous reconstitution, lipid raft fractionation, phosphorylation assays

    PMID:16354676

    Open questions at the time
    • Conflicts with later DRM-association findings on raft role
    • Heterologous system may not reflect neuronal context
  8. 2006 High

    Revealed a phosphorylation-independent role for DAB1 in APP/ApoER2 trafficking, increasing surface receptor levels and shifting APP toward non-amyloidogenic processing.

    Evidence Reciprocal Co-IP, surface biotinylation, NPXY domain mapping, Reelin treatment in multiple cell systems

    PMID:16951405

    Open questions at the time
    • In vivo relevance to amyloid pathology not established
    • Mechanism of surface stabilization not detailed
  9. 2006 High

    Discovered CRM1-dependent nucleocytoplasmic shuttling of DAB1 with mapped NLS/NES, indicating a nuclear function independent of Reelin/Fyn signaling.

    Evidence Leptomycin B treatment, deletion mutants, in vitro CRM1/RanGTP binding, immunofluorescence

    PMID:17062576

    Open questions at the time
    • Functional consequence of nuclear DAB1 unknown
    • No nuclear binding partners identified
  10. 2007 High

    Established Cullin5–SOCS-mediated proteasomal degradation of phospho-DAB1 as a negative-feedback brake on neuronal migration.

    Evidence Conditional Cul5 ablation in neurons, Cul5-SOCS-DAB1 complex biochemistry, DAB1 protein assays

    PMID:17974915

    Open questions at the time
    • Which SOCS protein is principal in vivo not pinned down at this stage
  11. 2007 High

    Extended the Src/Fyn→DAB1→CrkL pathway beyond cortex to sympathetic preganglionic neuron positioning in the spinal cord.

    Evidence Neuroanatomical analysis of dab1(5F/5F), src/fyn, and crkl knockout embryos

    PMID:17394141

    Open questions at the time
    • CrkL only partially required, implying additional effectors
  12. 2007 High

    Showed Fyn-dependent, DAB1-potentiated APP surface localization and α-secretase processing, with in vivo confirmation in Fyn-null mice.

    Evidence Co-IP, FLIM, surface biotinylation, Fyn knockout mice

    PMID:18089558

    Open questions at the time
    • Interplay between Fyn phosphorylation and the phosphorylation-independent APP effects unclear
  13. 2008 High

    Genetically dissected DAB1 tyrosines into two functional pairs—Y198/Y200 (Akt/downregulation) and Y220/Y232 (Crk/C3G)—with distinct cortical phenotypes.

    Evidence Paired Tyr→Phe knock-in mice, complementation, Akt assays, Crk Co-IP, layering analysis

    PMID:18981215

    Open questions at the time
    • How the two arms are integrated at the cellular level not resolved
  14. 2008 High

    Identified activated protein C as a non-Reelin ligand activating DAB1 through ApoER2-specific binding and PI3K/Akt/GSK3β signaling.

    Evidence SPR binding, ApoER2 siRNA, PI3K inhibition, phosphorylation assays in U937 cells

    PMID:19116273

    Open questions at the time
    • Physiological/developmental context of APC-DAB1 signaling unclear
  15. 2009 Medium

    Identified Pafah1b2 (Alpha2) as a phosphorylation-independent DAB1 partner that disrupts the DAB1-Lis1 complex, linking DAB1 to migration machinery.

    Evidence Co-IP from brain, cell-free binding, Alpha2 knockout mice

    PMID:19272360

    Open questions at the time
    • Single lab
    • Functional consequence of DAB1-Lis1 disruption in vivo not demonstrated
  16. 2009 Medium

    Revealed a non-neuronal-migration role for DAB1 in astrocyte caveola-mediated albumin endocytosis feeding neurotrophic oleic acid synthesis.

    Evidence siRNA knockdown, albumin endocytosis and oleic acid assays, Co-IP with caveolin-1/megalin, EM

    PMID:19656258

    Open questions at the time
    • Single lab
    • Whether this requires DAB1 phosphorylation not tested
  17. 2010 High

    Proved Cul5 controls layering solely through DAB1 degradation and quantified that DAB1 stabilization speeds migration by reducing stationary time.

    Evidence Stabilized DAB1 knock-in, Cul5 conditional KO, time-lapse migration imaging

    PMID:20410119

    Open questions at the time
    • Spatial/temporal triggers of degradation during migration not resolved
  18. 2010 Medium

    Showed DAB1 competes with Fe65 for APP binding and modulates APP-LRP1 complexes, refining the adaptor competition model for APP processing.

    Evidence Co-IP, competitive binding assays, APP processing measurements

    PMID:20568118

    Open questions at the time
    • No mutagenesis of binding interface
    • Single lab
  19. 2011 High

    Defined DAB1 as cell-autonomously required for Rap1/cadherin-dependent somal translocation (not glia-guided locomotion), explaining its migration-mode specificity.

    Evidence Conditional KO, in utero electroporation, Rap1/cadherin assays, time-lapse imaging

    PMID:21315259 PMID:21697392

    Open questions at the time
    • Mechanism by which Rap1 controls cadherin during translocation incomplete
  20. 2011 Medium

    Showed Fyn drives APP and DAB1 into detergent-resistant membranes where phospho-DAB1 concentrates, partially contradicting the raft-independence model.

    Evidence DRM fractionation from WT and Fyn KO mice, Co-IP, Reelin treatment

    PMID:21534960

    Open questions at the time
    • Single lab
    • Reconciliation with reconstitution data (idx 10) unresolved
  21. 2013 High

    Demonstrated an adult-brain function of DAB1 in synaptic plasticity and hippocampal learning via Akt/ERK signaling, separable from its developmental positioning role.

    Evidence Forebrain-specific conditional KO, behavior, electrophysiology, spine morphology, phospho-Akt/ERK assays

    PMID:24068831

    Open questions at the time
    • Upstream ligand/receptor for adult synaptic DAB1 signaling not defined
  22. 2013 Medium

    Placed DAB1 at a node of VEGF-Reelin crosstalk through Flk1-ApoER2 association and NR2B activation.

    Evidence Co-IP, Flk1 inhibition, DAB1 knockdown, reeler neuron rescue

    PMID:23916658

    Open questions at the time
    • Single lab
    • Physiological setting of VEGF-Reelin crosstalk unclear
  23. 2013 Medium

    Identified CIN85 as a phosphorylation-sensitive DAB1 partner coupling ApoER2/DAB1 to endosomal trafficking after Reelin.

    Evidence Co-IP, immunofluorescence with endosomal markers, Reelin stimulation

    PMID:23506116

    Open questions at the time
    • Single lab
    • Functional outcome of endosomal recruitment not established
  24. 2014 High

    Revealed an oncogenic DAB1 axis in colorectal cancer: NOTCH-induced DAB1 reciprocally activates ABL, which phosphorylates TRIO to drive RHO-dependent invasion.

    Evidence In vivo DAB1 depletion in polyposis mice, ABL inhibition, TRIO Y2681 mutants, GEF and invasion assays

    PMID:25432929

    Open questions at the time
    • Relationship of this ABL/TRIO arm to canonical Reelin signaling unclear
  25. 2015 High

    Connected mTORC1 hyperactivation to DAB1 destabilization via Cul5 upregulation, providing a mechanism for migration defects in tuberous sclerosis.

    Evidence TSC mouse models, patient tubers, Rheb overexpression, rapamycin, Cul5 knockdown, phospho-DAB1 blots

    PMID:26235615

    Open questions at the time
    • Direct transcriptional vs post-transcriptional control of Cul5 by mTORC1 not fully defined
  26. 2017 Medium

    Showed via optogenetics that DAB1 activation alone is sufficient to orient cell movement and control membrane dynamics.

    Evidence Cry2-based opto-DAB1, live imaging in COS7 and neurons, downstream signaling assays

    PMID:28272509

    Open questions at the time
    • Single lab gain-of-function
    • Does not establish endogenous spatiotemporal regulation
  27. 2018 High

    Established DCC/Netrin-1 as an additional receptor system activating DAB1 (Y220/Y232 phosphorylation) to drive the multipolar-to-bipolar transition.

    Evidence Co-IP domain mapping, in vivo knockdown, rescue with phospho-mimetic DAB1 and constitutively active Fyn

    PMID:29590626

    Open questions at the time
    • Cross-talk between DCC and Reelin receptor inputs not resolved
  28. 2018 High

    Demonstrated a vascular/endothelial role for DAB1 in CNS angiogenesis controlling laminin-α4 secretion and integrin-β1 activation that feeds back on neuronal migration and BBB integrity.

    Evidence Endothelial-specific conditional KO, vascularization analysis, laminin secretion and integrin activation assays

    PMID:30139844

    Open questions at the time
    • Endothelial DAB1 effector pathway downstream not fully mapped
  29. 2018 High

    Showed RBM4-controlled alternative splicing producing full-length DAB1 (exons 7/8) is required for cortical neuronal migration, in opposition to PTBP1.

    Evidence RIP-seq, Rbm4a KO brain, in vivo knockdown, isoform-specific rescue

    PMID:29581187

    Open questions at the time
    • How splice variation tunes signaling output quantitatively not detailed
  30. 2023 Medium

    Identified ZSWIM8 as a protein-quality-control ligase that recognizes DAB1 intrinsically disordered regions to clear misfolded DAB1, with KO causing migration and spine defects.

    Evidence Conditional Zswim8 KO, CRISPR KO neurons, ZSWIM8-DAB1 interaction and ubiquitination assays, morphology

    PMID:35989311

    Open questions at the time
    • Single lab
    • Distinction from Cul5-mediated phospho-dependent degradation not fully delineated
  31. 2023 Medium

    Identified TRIM40 as an E3 ligase promoting K48 polyubiquitination and degradation of DAB1, limiting Reelin/DAB1-driven inflammation in diabetic retinopathy.

    Evidence Co-IP, K48 ubiquitination assay, TRIM40 overexpression, AAV-TRIM40 in vivo

    PMID:37146559

    Open questions at the time
    • Single lab
    • Whether degradation is phosphorylation-dependent untested
  32. 2023 Medium

    Showed SMARCD3-mediated chromatin remodeling at the DAB1 locus activates Reelin-DAB1-Src signaling to drive medulloblastoma metastasis, nominating Src inhibition.

    Evidence ATAC/ChIP-seq, SMARCD3 manipulation, Src activation assays and inhibitor response in MB models

    PMID:36849558

    Open questions at the time
    • Single lab
    • Direct cis-element to DAB1 regulatory link not fully resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The function of nuclear DAB1 and how its multiple degradation routes (Cul5, ZSWIM8, TRIM40) are coordinated spatiotemporally during migration and in disease remain unresolved.
  • No nuclear binding partner or nuclear function identified
  • Coordination/hierarchy among E3 ligases unknown
  • Integration of multiple receptor inputs (Reelin, DCC, APC, VEGF) onto shared DAB1 outputs unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0008289 lipid binding 1
Localization
GO:0005886 plasma membrane 2 GO:0005634 nucleus 1 GO:0005768 endosome 1 GO:0005829 cytosol 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-1643685 Disease 3
Partners
APPCRKLCUL5DCCFYNLRP8PIK3R1VLDLR
Complex memberships
Cul5-SOCS E3 ubiquitin ligase complex

Evidence

Reading pass · 35 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Dab1 tyrosine phosphorylation is required for Reelin signaling during brain development. Mice expressing Dab1 with all tyrosine phosphorylation sites mutated phenocopy the Dab1-null mutant, demonstrating that phosphorylation at these sites (not merely Dab1 protein expression) is the functional output of Reelin signaling. Knock-in mouse expressing phosphorylation-site mutant Dab1 (all Tyr → Phe); in vivo neuronal positioning analysis Current biology : CB High 10959835
2003 Reelin-induced Dab1 phosphorylation (requiring Src family kinase activity) leads to interaction of Dab1 with the PI3K regulatory subunit p85α, activating PI3K and downstream Akt while inhibiting GSK3β. PI3K signaling is required for normal cortical plate formation. Efficient Dab1 phosphorylation is impaired by cholesterol depletion of the plasma membrane. Co-immunoprecipitation of Dab1 and p85α; pharmacological inhibition of Src and PI3K; neuronal migration assay; cholesterol depletion experiments The Journal of biological chemistry High 12882964
2004 Reelin stimulation promotes binding of Crk-family proteins (CrkL, CrkI, CrkII) to tyrosine-phosphorylated Dab1 (at Y220 and Y232), which activates the C3G guanine nucleotide exchange factor and stimulates Rap1 GTPase, defining a Dab1→CrkL→C3G→Rap1 pathway downstream of Reelin. Pulldown of phospho-Dab1 binding proteins from embryonic brain; MS identification; Co-IP in Reelin-stimulated neurons; Rap1 activation assay; mutation of Y220 and Y232 Current biology : CB High 15062102
2004 CrkII and CrkL bind to tyrosine-phosphorylated Dab1 (requiring Y220 or Y232) in a Reelin-promoted manner. Dab1 also indirectly associates with Dock1 via CrkII. Expression of Dab1 interferes with CrkII-dependent cell migration, and the rough-eye phenotype caused by phospho-Dab1 in Drosophila is rescued by loss-of-function of myoblast city (Dock1 ortholog), suggesting that phospho-Dab1 engages the Crk-Dock1-Rac signaling cassette. Mass spectrometry identification of Dab1-binding proteins; Co-IP; cell migration assay; Drosophila genetic rescue Journal of cell science High 15316068
2007 Reelin-induced degradation of Dab1 requires phosphorylation at specific tyrosine residues and the E3 ubiquitin ligase component Cullin 5 (Cul5). Cul5 forms complexes with SOCS proteins that bind phosphorylated Dab1 and target it for proteasomal degradation. Ablation of Cul5 in migrating neurons causes accumulation of active Dab1 and excess neuronal migration to the top of the cortical plate. Conditional ablation of Cul5 in neurons (in vivo); biochemical demonstration of Cul5-SOCS-Dab1 complexes; Dab1 protein level assays Genes & development High 17974915
2010 Cul5 regulates cortical layering exclusively by promoting Dab1 degradation: a stabilized Dab1 mutant that resists Cul5-dependent degradation phenocopies Cul5 deficiency, and Cul5 has no effect when Dab1 is absent. Cul5 removal increases neuronal migration speed by reducing stationary time and increasing step speed. Knock-in stabilized Dab1 mutant; Cul5 conditional knockout; in vivo neuronal migration analysis; time-lapse imaging The Journal of neuroscience High 20410119
2005 Dab1 PTB domain phosphoinositide-binding activity is required for membrane recruitment and basal Dab1 phosphorylation, while direct Dab1-receptor interaction is required for Reelin-stimulated (but not basal) Dab1 phosphorylation. These two binding activities are separable by distinct point mutations. Site-directed mutagenesis of Dab1 PTB domain; phosphorylation assays in neurons with Reelin stimulation Brain research. Molecular brain research High 16046028
2006 Dab1 interacts with APP and ApoER2 via their NPXY domains through the Dab1 PTB domain, increases surface levels of APP and ApoER2, and decreases Aβ production. Reelin treatment increases the Dab1-ApoER2 and Dab1-APP interactions and promotes α-secretase cleavage of APP while decreasing β-CTF and Aβ production. These effects are independent of Dab1 phosphorylation. Co-immunoprecipitation; surface biotinylation; live cell staining; transfection studies in cell lines and primary neurons; Reelin treatment The Journal of biological chemistry High 16951405
2006 Dab1 undergoes nucleocytoplasmic shuttling. In steady state it is cytoplasmic, but it accumulates in the nucleus upon CRM1 (exportin) inhibition. CRM1 binds Dab1 directly in a RanGTP-dependent manner. A bipartite nuclear localization signal and two CRM1-dependent nuclear export signals were mapped. Reelin stimulation or Fyn-induced tyrosine phosphorylation does not affect this subcellular distribution. Leptomycin B treatment; EGFP-Dab1 deletion/substitution mutants; in vitro binding with purified CRM1 and RanGTP; immunofluorescence in Neuro2a and primary neurons The Journal of biological chemistry High 17062576
2008 Dab1 has dual functions during brain development: two tyrosine residues (Y198/Y200) are required for Reelin-stimulated Dab1 phosphorylation at other sites, Akt activation, and Dab1 downregulation; the other two tyrosines (Y220/Y232) are required specifically to activate the Crk/CrkL-C3G pathway. Absence of the Crk/CrkL binding sites causes an unusual cortical layering phenotype distinct from complete Dab1 loss. Knock-in mice with pairs of Tyr→Phe mutations; complementation analysis; Akt activation assays; Crk/CrkL co-immunoprecipitation; cortical layering analysis Molecular and cellular biology High 18981215
2006 Reconstitution of the complete Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation does not depend on receptor localization in lipid rafts, and that phosphorylated Dab1 remains bound to the receptor tail after pathway activation. Stable reconstitution of pathway components in fibroblast cell lines; Reelin treatment; lipid raft fractionation; phosphorylation assays Molecular and cellular biology High 16354676
2004 High-affinity binding of Dab1 to Reelin receptors (VLDLR and ApoER2) via the PTB domain is important for positioning of late-born cortical plate neurons. A point mutation F158V that strongly reduces PTB domain binding to receptor cytoplasmic tails causes a subtle phenotype only in hemizygous animals, specifically affecting late cortical plate neurons. Knock-in mouse with Dab1 F158V point mutation; in vitro binding assay with receptor peptides; in vivo neuroanatomical analysis Brain research. Molecular brain research High 15249135
2011 Dab1 acts cell-autonomously in translocating neocortical neurons to stabilize leading processes in a Rap1-dependent manner during somal translocation. Rap1, downstream of Dab1, controls cadherin function to regulate glia-independent somal translocation. Dab1 is required for somal translocation but not glia-guided locomotion. Conditional knockout of Dab1; in utero electroporation; Rap1 and cadherin functional assays; time-lapse imaging of neuronal migration Neuron High 21315259
2007 Fyn kinase phosphorylates Dab1, and in the presence of Dab1, Fyn increases APP surface levels and promotes α-secretase cleavage (sAPPα production) and C-terminal fragment generation. Fyn-induced phosphorylation of APP at Y757 and increased APP surface levels are potentiated by Dab1. In vivo, Fyn knockout mice have decreased sAPPα, confirming Fyn's role in APP processing. Co-immunoprecipitation; co-immunostaining; FLIM; Fyn knockout mice; overexpression experiments; surface biotinylation The Journal of biological chemistry High 18089558
2008 Activated protein C (APC) binds with high affinity (~30 nM) to ApoER2 (but not VLDLR), triggering phosphorylation of Dab1 at Tyr-220 and Akt at Ser-473. APC-induced Dab1 and GSK3β phosphorylation is blocked by RAP (general LDL receptor antagonist) and by ApoER2 siRNA knockdown, establishing an APC→ApoER2→Dab1→PI3K/Akt→GSK3β pathway. Surface plasmon resonance binding; siRNA knockdown of ApoER2; pharmacological inhibition (LY294002); phosphorylation assays in U937 cells Proceedings of the National Academy of Sciences of the United States of America High 19116273
2011 Dab1 knockdown neurons in the developing neocortex fail to enter the primitive cortical zone (PCZ) and cannot complete terminal translocation. Dab1-dependent terminal translocation (not locomotion) is specifically required for proper inside-out lamination. Dab1-KD locomoting neurons can pass wild-type predecessors beneath the PCZ. In utero electroporation with Dab1 shRNA; time-lapse analysis; sequential labeling experiments; in vivo cortical layer analysis The Journal of neuroscience High 21697392
2018 Endothelial Dab1 (together with ApoER2) mediates Reelin proangiogenic signaling in the CNS. Deletion of Dab1 in endothelial cells reduces laminin-α4 secretion and decreases integrin-β1 activation in glial cells, which in turn impairs neuronal migration and blood-brain barrier properties. Endothelial cell-specific Dab1 conditional knockout; vascularization analysis of retina and cortex; laminin secretion assays; integrin activation assays Science High 30139844
2014 NOTCH signaling in colorectal cancer induces DAB1 expression. DAB1 is phosphorylated by ABL tyrosine kinase, which activates ABL reciprocally. Activated ABL phosphorylates TRIO (a RAC/RHOGEF protein) at Y2681, activating RHO and promoting colorectal cancer invasion and metastasis. Genetic depletion of DAB1 in intestinal polyposis mice; ABL inhibition; TRIO Y2681F phospho-mimetic and phospho-dead mutations; RHOGEF activity assay; invasion assays Cancer discovery High 25432929
2018 DCC (deleted in colorectal carcinoma) interacts with Dab1 via its P3 domain. Netrin-1 ligand of DCC induces Dab1 phosphorylation at Y220 and Y232. DCC knockdown or truncation of its P3 domain delays neuronal migration and impairs the multipolar-to-bipolar transition, which is rescued by phospho-mimetic Dab1 or constitutively active Fyn. Co-immunoprecipitation; domain truncation analysis; in utero electroporation knockdown; rescue with phospho-mimetic Dab1; Fyn constitutively active mutant Cell reports High 29590626
2009 Pafah1b2 (Alpha2 subunit of the Pafah1b complex) co-precipitates with Dab1 from brain extracts in a phosphorylation-independent manner, via a unique tyrosine residue on Alpha2. Alpha2 binding does not affect Dab1 phosphorylation but disrupts Dab1-Lis1 complex formation without affecting Dab1-VLDLR association. Co-immunoprecipitation from brain extracts; cell-free binding assays; Alpha2 knockout mice; phosphorylation assays Brain research Medium 19272360
2015 mTORC1 activation (as in TSC) upregulates Cul5 E3 ubiquitin ligase expression, leading to enhanced ubiquitination and degradation of phosphorylated Dab1, thereby impairing Reelin-Dab1 signaling and causing neuronal migration defects. Rapamycin treatment or Cul5 reduction restores Dab1 levels and normal neuronal migration. TSC mouse models; cortical tubers from TSC patients; Rheb overexpression; rapamycin treatment; Cul5 knockdown; Western blot for pDab1 and Cul5 Cell reports High 26235615
2017 Optogenetic activation of Dab1 (opto-Dab1) using light-induced Cry2 oligomerization is sufficient to activate downstream Reelin-Dab1 signals and control membrane protrusion, retraction, and ruffling with high spatiotemporal resolution. This shows that Dab1 activation alone is sufficient to orient cell movement. Optogenetic Cry2-Dab1 fusion (opto-Dab1); live cell imaging in COS7 cells and primary neurons; downstream signaling assays Scientific reports Medium 28272509
2013 Adult forebrain-specific conditional knockout of Dab1 in excitatory neurons causes defects in synaptic plasticity and hippocampal-dependent associative and spatial learning, accompanied by reduced dendritic spine size and defects in basal and plasticity-induced Akt and ERK1/2 signaling, without affecting neuronal positioning or dendrite morphology. Conditional knockout mouse (forebrain/excitatory neuron-specific Dab1 deletion); behavioral testing; electrophysiology; Akt/ERK1/2 phosphorylation assays; spine morphology analysis The Journal of neuroscience High 24068831
2007 Reelin-dependent Dab1 tyrosine phosphorylation by Src family kinases (Src/Fyn) is required for positioning of sympathetic preganglionic neurons (SPN) in the spinal cord. CrkL is partially required for Reelin-regulated SPN migration, establishing that the Dab1 tyrosine phosphorylation→CrkL pathway operates in spinal cord as well as cortex. Analysis of SPN position in dab1(5F/5F), src-/-fyn-/-, and crkl-/- mouse embryos; comparison to reeler phenotype The Journal of comparative neurology High 17394141
2004 Alternative splicing of chick Dab1 generates an early isoform (chDab1-E) lacking Src-family kinase recognition tyrosines and a late isoform (chDab1-L) containing them. Expression of chDab1-L induces morphological differentiation, Src kinase activation, and GAP-43 upregulation, while chDab1-E does not, with mutational analysis implicating Y198 specifically. Retinal culture transfection; morphological analysis; Src kinase phosphorylation assays; tyrosine mutagenesis (Y198F) The EMBO journal Medium 15057276
2009 In astrocytes, Dab1 (not Dab2) interacts with caveolin-1 and megalin, and is required for caveola-mediated endocytosis of albumin. Dab1 knockdown strongly reduces albumin internalization and the subsequent synthesis and release of the neurotrophic factor oleic acid. Dab1 siRNA knockdown in astrocyte primary cultures; albumin endocytosis assay; oleic acid synthesis measurement; Co-IP of Dab1 with caveolin-1 and megalin; electron microscopy Journal of neurochemistry Medium 19656258
2010 Fe65 interacts with Dab1 via the C-terminal region of Dab1 (phosphorylation-independent). Dab1 competes with Fe65 for binding to APP via overlapping PTB domain binding sites, reducing Fe65-APP interaction. Dab1 also reduces APP-LRP1 complex formation and alters APP processing. Co-immunoprecipitation; competitive binding assays; APP/LRP1/secreted APP level measurements Journal of cellular biochemistry Medium 20568118
2013 CIN85 colocalizes with ApoER2 in neurons in a Dab1-mediated, phosphorylation-independent manner at baseline. After Reelin stimulation, CIN85 is recruited to plasma membrane domains containing ApoER2 and Dab1, and then to EEA1-positive early endosomes. Tyrosine phosphorylation of Dab1 by Reelin strengthens the Dab1-CIN85 interaction. Co-immunoprecipitation; immunofluorescence in neurons; Reelin stimulation; endosomal marker co-localization Genes to cells Medium 23506116
2011 Fyn kinase promotes localization of both APP and Dab1 to detergent-resistant membrane (DRM/lipid raft) fractions. Nearly all tyrosine-phosphorylated Dab1 is in DRMs. Fyn knockout reduces DRM-associated APP, Dab1, and phospho-Dab1. Reelin treatment increases localization of APP and Dab1 to DRMs and decreases APP-Dab1 co-immunoprecipitation in a Fyn-dependent manner. DRM fractionation from wild-type and Fyn KO mice; co-immunoprecipitation; Reelin treatment of neurons; phosphorylation-deficient APP and Dab1 mutant expression Journal of neurochemistry Medium 21534960
2023 ZSWIM8 ubiquitin ligase controls protein quality of Dab1 by recognizing intrinsically disordered regions (IDRs) of Dab1 and eliminating misfolded Dab1 that cannot be properly phosphorylated. Conditional deletion of Zswim8 causes neuronal migration defects and impairs spine formation, associated with loss of normal Dab1 signaling strength. Conditional Zswim8 knockout in embryonic nervous system; CRISPR KO in hippocampal neurons; biochemical demonstration of ZSWIM8-Dab1 interaction; ubiquitination assays; spine/synapse morphology analysis Cerebral cortex Medium 35989311
2023 TRIM40 E3 ubiquitin ligase interacts with DAB1 and promotes K48-linked polyubiquitination and proteasomal degradation of DAB1, thereby limiting DAB1 stability and Reelin/DAB1 signaling-dependent inflammation in diabetic retinopathy. Co-IP and double immunofluorescence demonstrating TRIM40-DAB1 interaction; K48-linked ubiquitination assay; TRIM40 overexpression in cell and mouse models; AAV-TRIM40 injection Biochemical and biophysical research communications Medium 37146559
2005 Dab1 can complex with the cytoplasmic region of β1 integrin in a Reelin-dependent manner, while α3β1 integrin binds the N-terminal region of Reelin (distinct from the VLDLR/ApoER2 binding site), suggesting Dab1 can be recruited to integrin complexes upon Reelin stimulation. Co-immunoprecipitation; Reelin binding domain mapping; in vivo neuronal migration studies Cerebral cortex Medium 15703255
2013 VEGF treatment promotes association of VEGF receptor-2 (Flk1) with ApoER2 and leads to Flk1-dependent Dab1 phosphorylation and NR2B (NMDA receptor subunit) activation. VEGF treatment rescues deficits in phospho-Dab1 in reeler neurons, establishing Dab1 as a mediator of crosstalk between VEGF and Reelin signaling. Co-immunoprecipitation of Flk1-ApoER2; phosphorylation assays; Flk1 inhibition; Dab1 knockdown; reeler neuron rescue experiments Neuroscience letters Medium 23916658
2018 RBM4 RNA-binding protein directly regulates Dab1 alternative splicing, promoting inclusion of exons 7 and 8 in opposition to PTBP1. Full-length Dab1 (containing exons 7/8) but not the truncated isoform rescues neuronal migration defects in RBM4-depleted neurons, establishing that RBM4-controlled Dab1 splicing is required for cortical neuronal migration. RNA immunoprecipitation-sequencing; Rbm4a knockout brain; in utero electroporation knockdown; rescue with specific Dab1 isoforms Molecular and cellular biology High 29581187
2023 SMARCD3 (BAF60C) chromatin remodeler regulates DAB1 expression by orchestrating cis-regulatory elements at the DAB1 locus, and increased SMARCD3 activates Reelin-DAB1-mediated Src kinase signaling to drive medulloblastoma metastasis. Medulloblastomas with increased SMARCD3 show a Src inhibitor response. Integrative genomics (ATAC-seq, ChIP-seq); SMARCD3 manipulation; Src kinase activation assays; Src inhibitor treatment in MB models Nature cell biology Medium 36849558

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway. Neuron 313 14715136
2011 Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron 276 21315259
2000 Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development. Current biology : CB 230 10959835
2003 Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. The Journal of biological chemistry 184 12882964
2004 Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Current biology : CB 165 15062102
2006 DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing. The Journal of biological chemistry 143 16951405
2018 Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Science (New York, N.Y.) 132 30139844
1999 Thyroid hormone regulates reelin and dab1 expression during brain development. The Journal of neuroscience : the official journal of the Society for Neuroscience 132 10436054
2007 Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. Genes & development 127 17974915
2017 A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia. American journal of human genetics 112 28686858
2006 Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. The Journal of neuroscience : the official journal of the Society for Neuroscience 108 16467525
2001 Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proceedings of the National Academy of Sciences of the United States of America 106 11226314
2011 The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 98 21697392
2008 Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proceedings of the National Academy of Sciences of the United States of America 98 19116273
2014 Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO. Cancer discovery 89 25432929
2013 Dab1 is required for synaptic plasticity and associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience 75 24068831
2004 Interaction between Dab1 and CrkII is promoted by Reelin signaling. Journal of cell science 75 15316068
2003 Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain research. Developmental brain research 68 12586425
2005 Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development. Cerebral cortex (New York, N.Y. : 1991) 64 15703255
1998 Genomics and polymorphism of Agph-DAB1, an Mhc class II B gene in red-winged blackbirds (Agelaius phoeniceus). Molecular biology and evolution 64 9501491
2010 Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration. The Journal of neuroscience : the official journal of the Society for Neuroscience 62 20410119
2020 A circular RNA derived from DAB1 promotes cell proliferation and osteogenic differentiation of BMSCs via RBPJ/DAB1 axis. Cell death & disease 60 32415085
2002 A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development (Cambridge, England) 60 11830577
2007 ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proceedings of the National Academy of Sciences of the United States of America 52 17494763
2008 Dual functions of Dab1 during brain development. Molecular and cellular biology 51 18981215
2015 Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex. Cell reports 50 26235615
2002 Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience 50 12019323
2017 Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders. Cerebral cortex (New York, N.Y. : 1991) 44 26762856
2007 Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. The Journal of biological chemistry 44 18089558
2008 ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic (Copenhagen, Denmark) 43 18298590
2009 Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid. Journal of neurochemistry 40 19656258
2002 The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse. The Journal of biological chemistry 40 12446734
2006 Mouse Disabled1 (DAB1) is a nucleocytoplasmic shuttling protein. The Journal of biological chemistry 38 17062576
2004 Alternative splicing modulates Disabled-1 (Dab1) function in the developing chick retina. The EMBO journal 35 15057276
2007 A genetic interaction between the APP and Dab1 genes influences brain development. Molecular and cellular neurosciences 34 18029196
2006 Reconstitution of the Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation is independent of receptor localization in lipid rafts. Molecular and cellular biology 32 16354676
2018 DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons. Cell reports 30 29590626
2018 Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder. Human mutation 29 29969175
2023 A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis. Nature cell biology 27 36849558
2022 Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis. Neurobiology of aging 26 35977442
2020 Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury. CNS neuroscience & therapeutics 25 32115899
2019 Mutational mechanism for DAB1 (ATTTC)n insertion in SCA37: ATTTT repeat lengthening and nucleotide substitution. Human mutation 22 30588707
2019 Expression and localization of DAB1 and Reelin during normal human kidney development. Croatian medical journal 22 31894918
2018 RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Molecular and cellular biology 22 29581187
2023 The ZSWIM8 ubiquitin ligase regulates neurodevelopment by guarding the protein quality of intrinsically disordered Dab1. Cerebral cortex (New York, N.Y. : 1991) 21 35989311
2016 Reelin-Dab1 signaling system in human colorectal cancer. Molecular carcinogenesis 21 27434856
2007 Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL. The Journal of comparative neurology 19 17394141
2004 High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain research. Molecular brain research 19 15249135
2011 Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes. Journal of neurochemistry 18 21534960
2008 Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants. Molecular and cellular neurosciences 18 18786638
2023 ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease. Acta neuropathologica communications 17 38093390
2018 RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development (Cambridge, England) 17 29361558
2013 Transient downregulation of Dab1 protein levels during development leads to behavioral and structural deficits: relevance for psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 17 24030361
2009 Differential interaction of the Pafah1b alpha subunits with the Reelin transducer Dab1. Brain research 16 19272360
2017 Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurological research 15 28385118
2017 Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes. BioMed research international 15 28676854
2012 Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PloS one 15 22355340
2011 Neurologic function during developmental and adult stages in Dab1(scm) (scrambler) mutant mice. Behavioural brain research 15 21945093
1998 DAB1: a degenerate retrotransposon-like element from Neurospora crassa. Molecular & general genetics : MGG 15 9648750
2021 Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice. International journal of molecular sciences 14 33525532
2013 Association study between genes in Reelin signaling pathway and autism identifies DAB1 as a susceptibility gene in a Chinese Han population. Progress in neuro-psychopharmacology & biological psychiatry 14 23333377
2013 Neurobehavioral performances and brain regional metabolism in Dab1(scm) (scrambler) mutant mice. Behavioural brain research 14 23707934
2013 VEGF activates NR2B phosphorylation through Dab1 pathway. Neuroscience letters 14 23916658
2008 Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant mice. Neuroscience letters 14 18514414
2021 A Homozygous Dab1-/- Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract. Biomolecules 13 33924028
2010 Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing. Journal of cellular biochemistry 13 20568118
2009 Histological study in the brain of the reelin/Dab1-compound mutant mouse. Anatomical science international 13 19221860
2006 Identification of alternatively spliced dab1 isoforms in zebrafish. Development genes and evolution 13 16520940
2021 Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice. International journal of molecular sciences 12 34639052
2020 Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility. Human genome variation 12 33298905
2011 Identification of alternatively spliced Dab1 and Fyn isoforms in pig. BMC neuroscience 12 21294906
2011 Dab1 (Disable homolog-1) reelin adaptor protein is overexpressed in the olfactory bulb at early postnatal stages. PloS one 12 22046330
2008 Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons. Neurobiology of disease 12 18374587
2005 Both the phosphoinositide and receptor binding activities of Dab1 are required for Reelin-stimulated Dab1 tyrosine phosphorylation. Brain research. Molecular brain research 12 16046028
2000 Evolution of cortical lamination: the reelin/Dab1 pathway. Novartis Foundation symposium 11 10929319
2023 Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1-/-(yotari) Mice. Biomolecules 10 36979337
2021 Biallelic DAB1 Variants Are Associated With Mild Lissencephaly and Cerebellar Hypoplasia. Neurology. Genetics 10 33928188
2021 Sevoflurane Postconditioning Ameliorates Neuronal Migration Disorder Through Reelin/Dab1 and Improves Long-term Cognition in Neonatal Rats After Hypoxic-Ischemic Injury. Neurotoxicity research 10 34224102
2016 Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns. Scientific reports 10 27184477
2014 Dab1 and reelin participate in a common signal pathway that controls intestinal crypt/villus unit dynamics. Biology of the cell 10 24313315
2013 Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons. Genes to cells : devoted to molecular & cellular mechanisms 10 23506116
2023 Disturbances in Switching between Canonical and Non-Canonical Wnt Signaling Characterize Developing and Postnatal Kidneys of Dab1 (yotari) Mice. Biomedicines 9 37238991
2014 Aberrant fragment of Dab1 protein is present in yotari mouse. Neuroscience research 9 25149914
2024 m6A Methylation-Mediated Stabilization of LINC01106 Suppresses Bladder Cancer Progression by Regulating the miR-3148/DAB1 Axis. Biomedicines 8 38255219
2019 Functional Analysis of a Gene Cluster from Chitinophaga pinensis Involved in Biosynthesis of the Pyrrolidine Azasugar DAB-1. Journal of natural products 8 31793783
2017 Optogenetic control of the Dab1 signaling pathway. Scientific reports 8 28272509
2010 Sensorimotor learning in Dab1(scm) (scrambler) mutant mice. Behavioural brain research 8 21167868
2022 Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1 (yotari) Mice. International journal of molecular sciences 7 35216141
2020 Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway. Drug design, development and therapy 7 32943845
2020 Inhibition of microRNA-300 inhibits cell adhesion, migration, and invasion of prostate cancer cells by promoting the expression of DAB1. Cell cycle (Georgetown, Tex.) 7 33064976
2017 Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions. Development, growth & differentiation 7 28945921
2012 Abnormal grooming activity in Dab1(scm) (scrambler) mutant mice. Behavioural brain research 7 22561124
2004 Integrin and the Reelin-Dab1 pathway: a sticky affair? Brain research. Developmental brain research 7 15351515
2023 Heterozygous Dab1 Null Mutation Disrupts Neocortical and Hippocampal Development. eNeuro 6 36941061
2023 TRIM40 ameliorates diabetic retinopathy through suppressing inflammation via Reelin/DAB1 signaling disruption: A mechanism by proteasomal degradation of DAB1. Biochemical and biophysical research communications 6 37146559
2021 Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice. Molecular and cellular neurosciences 6 33845123
2009 Involvement of Dab1 in APP processing and beta-amyloid deposition in sporadic Creutzfeldt-Jakob patients. Neurobiology of disease 6 19853035
2001 Callosal commissural neurons of Dab1 deficient mutant mouse, yotari. Neuroscience research 6 11535289
2009 Characterisation and differential expression during development of a duplicate Disabled-1 (Dab1) gene from zebrafish. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 5 19931637
2024 Unraveling the Impact of Dab1 Gene Silencing on the Expression of Autophagy Markers in Lung Development. Life (Basel, Switzerland) 4 38541642

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