Affinage

PLXNB1

Plexin-B1 · UniProt O43157

Length
2135 aa
Mass
232.3 kDa
Annotated
2026-06-10
58 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PLXNB1 encodes a transmembrane semaphorin receptor that transduces extracellular cues into cytoskeletal and transcriptional responses governing cell migration, neural connectivity, bone homeostasis, and tumor/immune behavior (PMID:20877282, PMID:22019888). Activation requires that the semaphorin ligand Sema4D (and also Sema4A) bridge two receptor molecules into a 2:2 bivalent complex through conserved contacts of the N-terminal seven-bladed sema (β-propeller) domains; monomeric ligand binds but cannot signal, establishing ligand-stabilized receptor dimerization as the activation switch (PMID:20877282, PMID:29981480). Signaling output is dictated by dimer geometry: a face-to-face orientation matching that induced by Sema4D is agonistic, whereas an alternative orientation yields a signaling-incompetent dimer, and an allosteric groove between the fifth and sixth blades of the sema domain, distinct from the ligand site, can be exploited to block activation (PMID:27984026, PMID:35981535). Downstream, PLXNB1 couples to Rho-family GTPase signaling—activating RhoA (via PDZRhoGEF and the RhoA/ROCK axis) and modulating Rac1 GTP-loading—to control diverse outputs including suppression of osteoblast bone formation through inhibition of IGF-1 signaling (PMID:22019888), attenuation of photoreceptor outer-segment phagocytosis in retinal pigment epithelium (PMID:28624895), and EMT and invasion in cancer via a Vav1-Rac1/RhoA-PAK-Snail cascade (PMID:30981760, PMID:36936664). In the nervous system, PLXNB1 is required both pre- and postsynaptically for Sema4D/Sema4A-dependent GABAergic synapse formation and for cortical neurite outgrowth (PMID:23699507, PMID:29981480, PMID:37032361). Rare loss-of-function PLXNB1 variants cause neurite outgrowth deficits in patient iPSC-derived neurons (p.Ser454Arg) and impair GnRH neuronal migration (p.R1031H, in normosmic idiopathic hypogonadotropic hypogonadism) (PMID:35170806, PMID:37032361). PLXNB1 also shapes Alzheimer's disease pathology by governing peri-plaque glial distancing and a pathologic astrocyte state (PMID:38802590), and modulates the tumor immune microenvironment, where its blockade reprograms macrophages toward M1, boosts CD8+ T-cell infiltration, and enhances anti-PD-1 efficacy (PMID:38874583).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2010 High

    Resolved how a semaphorin engages PLXNB1 to switch it on, establishing that ligand-stabilized receptor dimerization—not mere binding—is the activation mechanism.

    Evidence X-ray crystallography of the PLXNB1 sema domain–SEMA4D ectodomain complex with mutagenesis and cellular signaling assays

    PMID:20877282

    Open questions at the time
    • Does not resolve how dimerization is propagated across the membrane to the intracellular GAP domain
    • No structure of the full-length receptor or intracellular signaling complex
  2. 2011 High

    Defined a physiological role for PLXNB1 in skeletal homeostasis, placing it in a Sema4D-RhoA-IGF-1 axis that restrains bone formation.

    Evidence Plxnb1-/-, Sema4d-/-, and osteoblast dominant-negative RhoA mouse models with bone phenotyping and IGF-1 signaling assays

    PMID:22019888

    Open questions at the time
    • Effector linking RhoA to IGF-1 pathway suppression not fully resolved
    • Cell-autonomous vs systemic contributions not dissected
  3. 2013 High

    Showed PLXNB1 is the receptor mediating rapid Sema4D-induced GABAergic synapse formation, extending plexin function to synaptic assembly.

    Evidence Loss-of-function in PlxnB1-/- mice, immunocytochemistry, live imaging, and slice electrophysiology in hippocampal neurons

    PMID:23699507

    Open questions at the time
    • Intracellular effectors recruiting synaptic proteins not identified
    • Whether RhoA or Rac mediate this synaptic effect unclear
  4. 2016 Medium

    Identified PLXNB1 as a context-dependent tumor suppressor acting upstream of MAPK in liver and downstream of ERG in prostate, framing dual roles in cancer.

    Evidence Genome-wide CRISPR knockout screen with transplantation and MAPK phosphorylation readout in hepatocytes; siRNA epistasis with invasion assays in prostate VCaP cells

    PMID:27956228 PMID:28004109

    Open questions at the time
    • Mechanism linking PLXNB1 loss to MAPK activation not defined
    • Single cell-line/model contexts limit generality
  5. 2016 High

    Discovered a druggable allosteric site on PLXNB1 distinct from the ligand site, providing a pharmacological route to block activation.

    Evidence High-affinity macrocyclic peptide PB1m6 binding assay, cell collapse assay, and X-ray crystallography of the PB1m6-PlxnB1 complex

    PMID:27984026

    Open questions at the time
    • In vivo efficacy of allosteric inhibition not tested in this study
    • How allosteric occupancy translates structurally to blocked dimerization unresolved
  6. 2017 High

    Linked PLXNB1 to Rac1-dependent regulation of a phagocytic process, showing it tunes RPE photoreceptor outer-segment clearance diurnally.

    Evidence In vitro Rac1 GTP-loading assays in differentiated RPE cells plus in situ phosphorylation analysis and knockout retina phenotyping

    PMID:28624895

    Open questions at the time
    • GEF/GAP intermediaries controlling Rac1 loading not identified
    • Mechanism of diurnal Sema4D/receptor phosphorylation regulation unclear
  7. 2018 Medium

    Refined the synaptic model by showing PLXNB1 is required in both pre- and postsynaptic compartments and serves as a shared receptor for Sema4D and Sema4A.

    Evidence Compartment-specific loss-of-function and immunocytochemistry in cultured hippocampal neurons

    PMID:29981480

    Open questions at the time
    • Methods partially inferred from abstract
    • Distinct downstream signaling for Sema4A vs Sema4D not resolved
  8. 2019 Medium

    Mapped a cancer signaling cascade downstream of PLXNB1, connecting Sema4D engagement to EMT and metastasis via Vav1-Rac1/RhoA-PAK-Snail.

    Evidence Xenograft mouse model, migration/invasion assays, siRNA knockdown, and anti-CD100 antibody treatment in head and neck squamous carcinoma

    PMID:30981760

    Open questions at the time
    • Single-lab pathway dissection
    • Relative contributions of Rac1 vs RhoA to Snail stabilization not quantified
  9. 2022 High

    Established the structural rule that dimer orientation, not just dimerization, dictates PLXNB1 signaling competence, using engineered agonist/antagonist dimerizers.

    Evidence Structural analysis of peptide-PlxnB1 complexes and cell-based signaling assays with Fc-based receptor dimerizers

    PMID:35981535

    Open questions at the time
    • Structural basis for how orientation alters intracellular GAP activity not shown
    • In vivo applicability of engineered dimerizers untested
  10. 2022 Medium

    Implicated PLXNB1 in human developmental and innate-immune phenotypes, tying a patient variant to GnRH neuron migration and Rnd1-PLXNB1 signaling to antibacterial cytokine production.

    Evidence Boyden chamber migration and membrane-expression assays for the p.R1031H IHH variant in GnRH cell lines; infection and cytokine assays with Rnd1 and Plxnb1

    PMID:35170806 PMID:35654795

    Open questions at the time
    • Single variant/single-lab functional support for IHH link
    • How Rnd1 engages PLXNB1 to drive IL-6/TNF-α mechanistically unclear
  11. 2023 High

    Demonstrated that point mutation can invert PLXNB1's function in cancer and confirmed causal roles in neurodevelopment via patient cells.

    Evidence Transgenic prostate cancer mouse models with Rho/ROCK and PDZRhoGEF deletion; patient iPSC-derived cortical neurons with rescue and PlxnB1 knockout-mouse neuron validation

    PMID:36936664 PMID:37032361

    Open questions at the time
    • How P1597L structurally rewires Rho/ROCK output not resolved
    • Generalizability of the metastasis-suppressor-to-promoter switch beyond prostate models unknown
  12. 2024 High

    Extended PLXNB1 function to disease-relevant glial and immune cell organization—governing peri-plaque glial distancing in Alzheimer's disease and shaping the tumor immune microenvironment.

    Evidence Cell-type-specific conditional knockout in an AD mouse model with histology/transcriptomics; PLXNB1-deficient and pharmacologically blocked breast carcinoma models with immune phenotyping and anti-PD-1 combination; scRNA-seq with Sema4D KO in aortic aneurysm

    PMID:38802590 PMID:38821358 PMID:38874583

    Open questions at the time
    • Cell-autonomous signaling effectors in astrocytes/macrophages not defined
    • Whether canonical Rho/Rac signaling underlies these cell-distancing and immune effects untested
  13. 2026 Medium

    Defined upstream regulatory inputs to PLXNB1 expression—epigenetic activation by ALDH1A3 and an opposing role in epithelial inflammation—broadening its regulatory and pathophysiological context.

    Evidence ChIP for H3K9/K14 acetylation at the PLXNB1 promoter with metastasis assays in PDAC; knockdown/overexpression with MAPK/p38 cytokine readouts in nasal epithelial cells; luciferase-validated miR-362-5p targeting in chondrogenic MSCs

    PMID:36523183 PMID:42221815 PMID:42224190

    Open questions at the time
    • Single-lab/single-model support for each regulatory axis
    • How PLXNB1 negatively regulates MAPK/p38 inflammation mechanistically unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the extracellular dimerization/orientation switch is mechanically transmitted to the intracellular GAP domain to selectively activate RhoA versus Rac1 in different cell types remains the central open question.
  • No full-length structure linking ectodomain orientation to intracellular GAP state
  • Determinants of cell-type-specific RhoA vs Rac1 output unknown
  • Identity of GEFs/GAPs coupling PLXNB1 to GTPases across tissues incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0001618 virus receptor activity 3 GO:0060089 molecular transducer activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 2
Partners
ARHGEF11RAC1RHOARND1SEMA4ASEMA4D

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 Crystal structures of the PLXNB1 sema domain (residues 1-2) in complex with SEMA4D ectodomain revealed that semaphorin dimers bind two plexin molecules independently, forming a 2:2 bivalent complex. Monomeric semaphorin binds PLXNB1 but fails to trigger signaling, demonstrating that signaling requires avidity of the bivalent complex. The interaction is mediated through conserved contacts of the N-terminal seven-bladed β-propeller (sema) domains of both semaphorin and plexin, suggesting semaphorin-stabilized plexin dimerization as the activation mechanism. X-ray crystallography, biophysical assays, cellular signaling assays with wild-type and mutant proteins Nature High 20877282
2011 Binding of Sema4D (secreted by osteoclasts) to its receptor Plexin-B1 on osteoblasts activates the small GTPase RhoA, which suppresses bone formation by inhibiting IGF-1 signaling and modulating osteoblast motility. Plxnb1-/- mice display an osteosclerotic phenotype due to augmented bone formation, placing PLXNB1 in the Sema4D-RhoA-IGF-1 signaling axis in bone homeostasis. Genetic knockout mouse models (Plxnb1-/-, Sema4d-/-, dominant-negative RhoA transgenic in osteoblasts), bone phenotype analysis, IGF-1 signaling assays Nature medicine High 22019888
2013 Sema4D promotes rapid GABAergic synapse formation in rodent hippocampus via its receptor PlexinB1; this effect is dependent on PlexinB1 as it is abolished in PlxnB1-/- mice. Sema4D-PlexinB1 signaling initiates synapse formation by recruiting synaptic proteins to both presynaptic and postsynaptic terminals within 10-30 minutes. Loss-of-function genetic screen, immunocytochemistry, live imaging in cultured hippocampal neurons and PlxnB1-/- mice, organotypic slice electrophysiology The Journal of neuroscience High 23699507
2016 A high-affinity macrocyclic peptide PB1m6 (KD = 3.5 nM) binds PLXNB1 at a groove between the fifth and sixth blades of the sema domain, distant from the Sema4D-binding site. This allosteric binding competitively inhibits Sema4D binding in vitro and completely suppresses Sema4D-induced cell collapse, identifying a novel allosteric site on PLXNB1. In vitro binding assay, cell collapse assay, X-ray crystallography of PB1m6-PlxnB1 complex Cell chemical biology High 27984026
2017 Sema4D binding to PlexinB1 on retinal pigment epithelium (RPE) cells attenuates photoreceptor outer segment (POS) phagocytosis by decreasing GTP-loading of Rac1. PlexinB1 phosphorylation and Sema4D levels are reduced at the peak of diurnal phagocytosis after light onset in vivo; plxnb1-/- or sema4d-/- mice show increased POS phagosome content after light onset. In vitro Rac1 GTP-loading assay in differentiated RPE cells, in situ analysis in wild-type and mutant rat/mouse retina, genetic knockout models Molecular neurobiology High 28624895
2018 Plexin-B1 requires its presence in both the presynaptic axon of inhibitory interneurons and the postsynaptic dendrites of excitatory neurons for Sema4D-dependent inhibitory synapse development in rodent hippocampus. Sema4A also signals through postsynaptic PlexinB1 to promote inhibitory synapse development, using the same pathway as Sema4D. Compartment-specific loss-of-function experiments in cultured hippocampal neurons, immunocytochemistry, genetic approaches Molecular and cellular neurosciences Medium 29981480
2019 Soluble CD100 (Sema4D) induces epithelial-mesenchymal transition (EMT) in head and neck squamous cell carcinoma through its receptor Plexin-B1, and promotes metastasis in a xenograft mouse model. The signaling mechanism involves the Vav1-Rac1/RhoA-p21-activated kinase pathway leading to Snail stabilization. Xenograft mouse model, cell migration/invasion assays, western blot, siRNA knockdown, anti-CD100 antibody treatment Cancer letters Medium 30981760
2022 A PLXNB1 variant (p.R1031H) identified in normosmic IHH patients shows reduced membrane expression and impaired cell migration in GnRH neuronal cell lines compared to wild-type PlexinB1, implicating PLXNB1 in GnRH cell migration during development. Boyden chamber migration assay, flow cytometry/western blot for membrane expression, bioinformatic modeling Journal of neuroendocrinology Medium 35170806
2022 Rnd1 (a constitutively active Rho GTPase) facilitates pro-inflammatory cytokine (IL-6 and TNF-α) production during bacterial infection through PlexinB1, providing a Rnd1-PLXNB1-mediated innate immune defense mechanism against intracellular bacterial infections. In vitro infection assays, cytokine measurements, functional assays with Rnd1 and Plxnb1 Cell death & disease Medium 35654795
2022 De novo Fc-based receptor dimerizers grafted with different PLXNB1-binding peptides can act as either agonists or antagonists of PlexinB1. Structural analysis revealed that the agonistic Fc dimerizes PlxnB1 in a face-to-face fashion similar to that induced by Sema4D, whereas the antagonistic Fc induces a signaling-incompetent dimer conformation, demonstrating that plexin activation is controlled by receptor orientation within the dimer. Structural analysis of peptide-PlxnB1 complexes, cell-based signaling assays with Fc dimerizers Structure High 35981535
2023 A rare homozygous loss-of-function PLXNB1 variant (p.Ser454Arg) causes neurite outgrowth deficits in patient iPSC-derived cortical neurons. Expression of wild-type PLXNB1, but not the variant, rescued neurite outgrowth in patient neurons; expression of the variant caused neurite outgrowth deficits in cortical neurons from PlxnB1 knockout mice, establishing PLXNB1 as a regulator of neurite outgrowth. iPSC-derived cortical neurons from patient and controls, rescue experiments with wild-type vs. variant PLXNB1, PlxnB1 knockout mouse neurons, transcriptomic profiling of organoids Molecular psychiatry High 37032361
2023 Prostate epithelial cell-specific expression of a clinically identified mutant Plexin-B1 (P1597L) significantly increases metastasis in two transgenic prostate cancer mouse models, whereas wild-type Plexin-B1 expression suppresses metastasis, demonstrating that P1597L converts PLXNB1 from a metastasis suppressor to a metastasis promoter. Deletion of RhoA/C or PDZRhoGEF suppressed metastasis in this context, implicating the Rho/ROCK pathway in the phenotypic switch. Transgenic mouse models (PbCre), germline and conditional deletion, RhoA/C and PDZRhoGEF deletion, metastasis quantification, invasion assays Cancer research communications High 36936664
2024 Plexin-B1 is upregulated in plaque-associated astrocytes in Alzheimer's disease and governs cell distancing in peri-plaque glial nets. Plexin-B1 deletion in a mouse AD model reduced the number of reactive astrocytes and microglia in peri-plaque nets but increased glial process coverage of plaques, reduced overall plaque burden, shifted plaques toward dense-core type, and reduced neuritic dystrophy and neuroinflammatory transcriptional signatures. Conditional knockout in AD mouse model, histology, transcriptomics, plaque morphology analysis Nature neuroscience High 38802590
2024 PlexinB1 inactivation in the tumor microenvironment (TME) of triple-negative murine breast carcinoma reduces primary tumor growth and metastatic dissemination, associated with a switch of tumor-associated macrophages toward a pro-inflammatory M1 phenotype, enhanced CD8+ T lymphocyte infiltration, and upregulation of anti-tumor genes (Icos, Perforin-1, Stat3, Ccl5) in TILs. Pharmacological PLXNB1 blockade phenocopied genetic deletion and enhanced anti-PD-1 immunotherapy efficacy. PLXNB1-deficient mouse model, flow cytometry, gene expression profiling of TILs, pharmacological inhibition, anti-PD-1 combination treatment Cancer immunology research High 38874583
2024 Sema4D secreted by osteoclast-like cells induces sympathetic nerve diffusion and hyperinnervation through binding to Plxnb1, contributing to abdominal aortic aneurysm development. This was identified by single-cell RNA sequencing and validated in Sema4D-deficient mice showing reduced AAA progression. Single-cell RNA sequencing, Sema4D knockout mouse model, immunostaining Journal of advanced research Medium 38821358
2025 Genetic ablation of PLXNB1 in murine and human iPSC-derived astrocytes decreased the Ast10 (SLC38A2-high) pathologic astrocyte state signature in Alzheimer's disease, confirming PLXNB1 as a regulator of this disease-associated astrocyte state that contributes to cognitive decline through synaptic loss. Genetic ablation in murine astrocytes and human iPSC-derived astrocytes, single-nucleus RNA-seq meta-analysis, spatial transcriptomics validation bioRxivpreprint Medium 40060644
2016 CRISPR-mediated knockout of Plxnb1 in p53-null/Myc-overexpressing mouse hepatocytes increased liver tumor formation and was associated with increased MAPK phosphorylation, identifying PLXNB1 as a suppressor of liver tumor formation that acts upstream of the MAPK pathway. Genome-wide CRISPR/Cas9 knockout screen, subcutaneous and orthotopic transplantation in mice, immunohistochemistry for MAPK phosphorylation Gastroenterology Medium 27956228
2016 PLXNB1 expression is regulated by the TMPRSS2-ERG fusion gene in prostate cancer cells, and PLXNB1 (but not MMP-9) contributes to TMPRSS2-ERG-mediated enhancement of cancer cell migration and invasion in VCaP cells, placing PLXNB1 downstream of ERG as a mediator of invasion. siRNA knockdown of ERG, MMP-9, and PLXNB1; MTT and Transwell invasion assays; qRT-PCR and western blot Oncology reports Medium 28004109
2022 miR-362-5p directly targets PLXNB1 mRNA (confirmed by luciferase reporter assay), suppressing PLXNB1 expression and thereby inhibiting chondrogenic differentiation of bone marrow mesenchymal stem cells; PLXNB1 overexpression promotes chondrogenic differentiation and alleviates joint injury in an in vivo OA rat model. Luciferase reporter assay, RT-qPCR, western blot, chondrogenic differentiation assays, micro-CT in OA rat model Journal of orthopaedic surgery (Hong Kong) Medium 36523183
2026 ALDH1A3 promotes acetyl-CoA production and enhances H3K9/K14 histone acetylation at the PLXNB1 promoter, activating PLXNB1 transcription in pancreatic ductal adenocarcinoma. This sensitizes PDAC cells to SEMA4D from lung epithelial cells, driving SEMA4D-PLXNB1 signaling-mediated lung metastatic colonization. RNA sequencing, ChIP for histone acetylation at PLXNB1 promoter, in vitro and in vivo metastasis assays iScience Medium 42221815
2026 PLXNB1 knockdown in human nasal epithelial cells increases expression of inflammatory cytokines (IL-4, IL-6), likely via activation of the MAPK/p38 signaling pathway, while PLXNB1 overexpression suppresses inflammation, indicating PLXNB1 negatively regulates MAPK/p38-driven inflammation in epithelial cells. In vitro PLXNB1 knockdown and overexpression in nasal epithelial cells, cytokine assays, in vivo AR mouse model PloS one Medium 42224190

Source papers

Stage 0 corpus · 58 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nature medicine 385 22019888
2010 Structural basis of semaphorin-plexin signalling. Nature 200 20877282
2018 Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Annals of neurology 115 29908079
2016 Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. Gastroenterology 98 27956228
2004 Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development. The European journal of neuroscience 69 15147296
2005 The expression of plexins during mouse embryogenesis. Gene expression patterns : GEP 65 15661641
2010 Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons. Journal of neuroscience research 64 20882566
2016 Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide. Cell chemical biology 63 27984026
2022 Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats. Journal of nanobiotechnology 62 35236339
2013 The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 42 23699507
2013 An integrative characterization of recurrent molecular aberrations in glioblastoma genomes. Nucleic acids research 37 23907387
2018 Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus. Molecular and cellular neurosciences 36 29981480
2013 Genetic risk factors in two Utah pedigrees at high risk for suicide. Translational psychiatry 35 24252905
2024 Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease. Nature neuroscience 31 38802590
2010 Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation; research in biological diversity 30 21035938
2021 Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells. Human genomics 29 34802461
2024 Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization. The journal of headache and pain 25 38867170
2017 Involvement of DPP9 in gene fusions in serous ovarian carcinoma. BMC cancer 23 28893231
2021 3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing. Acta pharmaceutica Sinica. B 20 34729306
2019 CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis. Cancer letters 18 30981760
2022 Spatial Organization of Osteoclastic Coupling Factors and Their Receptors at Human Bone Remodeling Sites. Frontiers in molecular biosciences 17 35775083
2015 MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603. Clinical epigenetics 17 26052356
2017 Semaphorin4D-PlexinB1 Signaling Attenuates Photoreceptor Outer Segment Phagocytosis by Reducing Rac1 Activity of RPE Cells. Molecular neurobiology 15 28624895
2024 Identification of Immune-Related Biomarkers of Schizophrenia in the Central Nervous System Using Bioinformatic Methods and Machine Learning Algorithms. Molecular neurobiology 14 39243324
2021 Unearthing of Key Genes Driving the Pathogenesis of Alzheimer's Disease via Bioinformatics. Frontiers in genetics 14 33936168
2020 The emerging roles of semaphorin4D/CD100 in immunological diseases. Biochemical Society transactions 13 33258873
2019 Cognition may link cortical IGFBP5 levels with motor function in older adults. PloS one 13 31404102
2023 Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models. Cancer research communications 11 36936664
2022 Circular RNA circ_0065378 upregulates tumor suppressor candidate 1 by competitively binding with miR-4701-5p to alleviate colorectal cancer progression. Journal of gastroenterology and hepatology 11 35434854
2020 Correlations Among Genotype and Outcome in Chinese Male Patients With Congenital Hypogonadotropic Hypogonadism Under HCG Treatment. The journal of sexual medicine 11 32171629
2016 Identification of TMPRSS2-ERG mechanisms in prostate cancer invasiveness: Involvement of MMP-9 and plexin B1. Oncology reports 11 28004109
2019 Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons. Journal of affective disorders 10 30875674
2018 Prostate cancer tissues with positive TMPRSS2-ERG-gene-fusion status may display enhanced nerve density. Urologic oncology 10 30241953
2023 Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder. Molecular psychiatry 9 37032361
2022 Essential role of Rnd1 in innate immunity during viral and bacterial infections. Cell death & disease 9 35654795
2019 Long noncoding RNA ZEB2-AS1 facilitates laryngeal squamous cell carcinoma progression by miR-6840-3p/PLXNB1 axis. OncoTargets and therapy 9 31564916
2022 De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function. Structure (London, England : 1993) 8 35981535
2018 SEMA4D-heparin Complexes Immobilized on Titanium Surfaces Have Anticoagulant, Cell-Migration-Promoting, and Immunoregulatory Effects. ACS biomaterials science & engineering 8 33445317
2024 Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching. Journal of advanced research 7 38821358
2022 MiR-362-5p inhibits cartilage repair in osteoarthritis via targeting plexin B1. Journal of orthopaedic surgery (Hong Kong) 7 36523183
2022 Methylation-based epigenetic studies and gene integration analysis of preeclampsia. Annals of translational medicine 7 36660680
2024 PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination. Cancer immunology research 6 38874583
2024 PLXNB1/SEMA4D signals mediate interactions between malignant epithelial and immune cells to promote colorectal cancer liver metastasis. Journal of cellular and molecular medicine 6 39443302
2022 PLXNB1 mutations in the etiology of idiopathic hypogonadotropic hypogonadism. Journal of neuroendocrinology 6 35170806
2019 Transcriptome Analysis Reveals Novel Genes Associated with Cartilage Degeneration in Posttraumatic Osteoarthritis Progression. Cartilage 6 31104480
2024 Former smoking associated with epigenetic modifications in human granulosa cells among women undergoing assisted reproduction. Scientific reports 5 38424222
2025 Conventional and genetic association between migraine and stroke with druggable genome-wide Mendelian randomization. Human genetics 4 39841246
2025 PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease. bioRxiv : the preprint server for biology 3 40060644
2025 Generation of Plexin-B1 Conditional Knockout Mouse With CRISPR/Cas9 Technology. Genesis (New York, N.Y. : 2000) 2 40566742
2024 A phase 1/2 study of pepinemab in children, adolescents, or young adults with recurrent or refractory solid tumors: A children's oncology group consortium report (ADVL1614). Pediatric blood & cancer 2 38520670
2025 SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain. bioRxiv : the preprint server for biology 1 40667014
2023 Leprosy-specific subsets of macrophages and Schwann cells identified by single-cell RNA-sequencing. Pathology, research and practice 1 37757621
2026 Research article proteomics-based plasma biomarkers for predicting CRKP infection in ICU sepsis patients. Frontiers in pharmacology 0 41908830
2026 ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signaling. iScience 0 42221815
2026 Study on the pathogenesis of PLXNB1 gene in olfactory dysfunction of allergic rhinitis. PloS one 0 42224190
2025 Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson's disease. Molecular brain 0 41327336
2025 Kazachstania pintolopesii triggers an immune-endothelial-fibroblast cascade and drives inflammatory arthritis and tissue fibrosis in genetically susceptible hosts. Frontiers in cellular and infection microbiology 0 41459160
2024 Participation of Semaphorin Family and Plexins in the Clinical Course of Patients with Inflammatory Bowel Disease. International journal of molecular sciences 0 39596507

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