- Length
- 192 aa
- Mass
- 21.4 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
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Mechanism profile
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Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1992 | The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. | Cell | 3298 | 1643658 |
| 2004 | Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. | Nature cell biology | 1726 | 15467718 |
| 2005 | A human protein-protein interaction network: a resource for annotating the proteome. | Cell | 1704 | 16169070 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 1994 | A brain serine/threonine protein kinase activated by Cdc42 and Rac1. | Nature | 1377 | 8107774 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | Cell | 1015 | 26496610 |
| 2014 | A proteome-scale map of the human interactome network. | Cell | 977 | 25416956 |
| 2012 | Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. | Nature genetics | 946 | 22842228 |
| 2009 | A genetically encoded photoactivatable Rac controls the motility of living cells. | Nature | 889 | 19693014 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2008 | Rac activation and inactivation control plasticity of tumor cell movement. | Cell | 794 | 18984162 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 1996 | Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. | Cell | 734 | 8625410 |
| 2007 | Large-scale mapping of human protein-protein interactions by mass spectrometry. | Molecular systems biology | 733 | 17353931 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2012 | A census of human soluble protein complexes. | Cell | 689 | 22939629 |
| 2002 | Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. | Nature | 666 | 12181570 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 1998 | WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. | The EMBO journal | 588 | 9843499 |
| 2000 | Localized Rac activation dynamics visualized in living cells. | Science (New York, N.Y.) | 572 | 11030651 |
| 1995 | A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. | The Journal of biological chemistry | 552 | 7493928 |
| 1997 | Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. | Genes & development | 546 | 9042860 |
| 2000 | Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. | Nature immunology | 536 | 11101877 |
| 2002 | Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. | Cell | 502 | 12110184 |
| 2011 | Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. | Nature cell biology | 490 | 21423176 |
| 2002 | Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. | Nature cell biology | 482 | 12134158 |
| 2003 | Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. | Genes & development | 470 | 12533515 |
| 1989 | rac, a novel ras-related family of proteins that are botulinum toxin substrates. | The Journal of biological chemistry | 457 | 2674130 |
| 2000 | IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. | Nature | 454 | 11130076 |
| 2004 | Integrins regulate Rac targeting by internalization of membrane domains. | Science (New York, N.Y.) | 452 | 14764880 |
| 2002 | P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. | Cell | 447 | 11955434 |
| 2003 | Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. | Science (New York, N.Y.) | 398 | 14564009 |
| 1997 | Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. | The Journal of experimental medicine | 341 | 9348306 |
| 2004 | Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis. | Molecular biology of the cell | 299 | 15169870 |
| 2009 | Rac1 GTPase: a "Rac" of all trades. | Cellular and molecular life sciences : CMLS | 295 | 19151919 |
| 2006 | Requirement of Rac1 in the development of cardiac hypertrophy. | Proceedings of the National Academy of Sciences of the United States of America | 240 | 16651530 |
| 2000 | Vav2 is an activator of Cdc42, Rac1, and RhoA. | The Journal of biological chemistry | 227 | 10744696 |
| 2005 | Stem cell depletion through epidermal deletion of Rac1. | Science (New York, N.Y.) | 215 | 16081735 |
| 1998 | Fc receptor-mediated phagocytosis requires CDC42 and Rac1. | The EMBO journal | 196 | 9799231 |
| 1996 | Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. | Oncogene | 154 | 8760286 |
| 1998 | Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. | Molecular and cellular biology | 135 | 9447972 |
| 1998 | RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs. | Molecular biology of the cell | 135 | 9614181 |
| 2000 | Membrane recruitment of Rac1 triggers phagocytosis. | Journal of cell science | 120 | 10934035 |
| 1996 | The Ras-related GTPase Rac1 binds tubulin. | The Journal of biological chemistry | 112 | 8631991 |
| 2011 | S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. | Blood | 111 | 21757621 |
| 2006 | Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS). | Oncogene | 110 | 16462764 |
| 2014 | TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1. | The Journal of clinical investigation | 104 | 25295536 |
| 2007 | Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis. | The Journal of biological chemistry | 104 | 17573353 |
| 2008 | cAMP induced Rac 1-mediated cytoskeletal reorganization in microvascular endothelium. | Histochemistry and cell biology | 91 | 18392843 |
| 2012 | CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis. | The Journal of cell biology | 90 | 22945935 |
| 2005 | Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 90 | 15883643 |
| 2016 | Rac1 and RhoA: Networks, loops and bistability. | Small GTPases | 86 | 27533896 |
| 2009 | The small GTPase Rac1 regulates auditory hair cell morphogenesis. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 83 | 20016102 |
| 2016 | Impact of point mutation P29S in RAC1 on tumorigenesis. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 81 | 27699663 |
| 2013 | miR-320a suppresses colorectal cancer progression by targeting Rac1. | Carcinogenesis | 80 | 24265291 |
| 2006 | Sos-mediated activation of rac1 by p66shc. | The Journal of cell biology | 78 | 16520382 |
| 2006 | E-cadherin engagement stimulates proliferation via Rac1. | The Journal of cell biology | 78 | 16682529 |
| 2003 | Modulation of Rac1 and ARF6 activation during epithelial cell scattering. | The Journal of biological chemistry | 78 | 12609992 |
| 2021 | KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. | Molecular cancer | 77 | 34006303 |
| 2010 | Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. | Journal of cell science | 77 | 20460433 |
| 2003 | Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. | The Journal of biological chemistry | 76 | 12885773 |
| 2017 | Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling. | Cell reports | 75 | 29141223 |
| 2018 | Compartmentalisation of RAC1 signalling. | Current opinion in cell biology | 71 | 29723737 |
| 2013 | Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease. | PloS one | 70 | 24244677 |
| 2020 | Sarcoidosis and the mTOR, Rac1, and Autophagy Triad. | Trends in immunology | 69 | 32122794 |
| 2018 | Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. | Nature cell biology | 69 | 30250061 |
| 2019 | Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. | Nature communications | 68 | 31484924 |
| 2016 | Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. | Nature communications | 65 | 26887924 |
| 2015 | RAC1 P29S regulates PD-L1 expression in melanoma. | Pigment cell & melanoma research | 63 | 26176707 |
| 2005 | Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. | Histochemistry and cell biology | 63 | 16195887 |
| 2002 | DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. | Blood | 63 | 12393632 |
| 2015 | Modulation of actin dynamics by Rac1 to target cognitive function. | Journal of neurochemistry | 61 | 25818528 |
| 2005 | Selective Rac-1 inhibition protects from diabetes-induced vascular injury. | Circulation research | 61 | 16357302 |
| 2018 | Optogenetic dissection of Rac1 and Cdc42 gradient shaping. | Nature communications | 60 | 30446664 |
| 2006 | Alsin/Rac1 signaling controls survival and growth of spinal motoneurons. | Annals of neurology | 59 | 16802292 |
| 2016 | Rab7a regulates cell migration through Rac1 and vimentin. | Biochimica et biophysica acta. Molecular cell research | 57 | 27888097 |
| 2012 | Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 56 | 23197717 |
| 2005 | Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1. | PLoS pathogens | 56 | 16228016 |
| 2008 | Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2. | Journal of immunology (Baltimore, Md. : 1950) | 55 | 18684957 |
| 2007 | The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. | The Journal of biological chemistry | 55 | 17984089 |
| 2004 | Regulation of anoikis by Cdc42 and Rac1. | Experimental cell research | 54 | 15093747 |
| 2004 | Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation. | The Journal of biological chemistry | 54 | 15102830 |
| 2016 | GEFs: Dual regulation of Rac1 signaling. | Small GTPases | 53 | 27314616 |
| 2012 | Serine-71 phosphorylation of Rac1 modulates downstream signaling. | PloS one | 53 | 22970203 |
| 2018 | Post-Translational Modification and Subcellular Distribution of Rac1: An Update. | Cells | 51 | 30544910 |
| 2014 | mTOR regulate EMT through RhoA and Rac1 pathway in prostate cancer. | Molecular carcinogenesis | 50 | 25043657 |
| 2014 | Rac-1 as a new therapeutic target in cerebro- and cardio-vascular diseases. | Current drug targets | 49 | 25345393 |
| 2006 | Rac1 GTPase regulates cell genomic stability and senescence. | The Journal of biological chemistry | 47 | 17032649 |
| 2019 | Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion. | Current biology : CB | 46 | 31422887 |
| 2016 | Tiam1/Rac1 complex controls Il17a transcription and autoimmunity. | Nature communications | 46 | 27725632 |
| 2017 | Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors. | Oncogene | 45 | 29059171 |
| 2022 | Rac1 as a therapeutic anticancer target: Promises and limitations. | Biochemical pharmacology | 41 | 35853497 |
| 2007 | Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells. | Journal of cell science | 41 | 17227793 |
| 2015 | mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis. | PLoS genetics | 40 | 26132202 |
| 2015 | Distinct predictive performance of Rac1 and Cdc42 in cell migration. | Scientific reports | 40 | 26634649 |
| 2014 | Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. | Journal of cell science | 37 | 25074804 |
| 2014 | RAC1 and melanoma. | Clinical therapeutics | 37 | 25465943 |
| 1998 | p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes. | Oncogene | 37 | 9796702 |
| 2016 | Emerging roles of RAC1 in treating lung cancer patients. | Clinical genetics | 36 | 27790713 |
| 2014 | Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development. | Journal of the American Heart Association | 36 | 25315346 |
| 2022 | Overexpressed or hyperactivated Rac1 as a target to treat hepatocellular carcinoma. | Pharmacological research | 35 | 35405309 |
| 2013 | GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. | Proceedings of the National Academy of Sciences of the United States of America | 35 | 24297929 |
| 2012 | Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin. | Journal of cell science | 34 | 22946057 |
| 2014 | CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa. | Journal of cell science | 33 | 24790223 |
| 2014 | Redox regulation of Rac1 by thiol oxidation. | Free radical biology & medicine | 33 | 25289457 |
| 2002 | Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis. | Infection and immunity | 33 | 12117970 |
| 2013 | The small GTPase Rac1 is required for smooth muscle contraction. | The Journal of physiology | 32 | 24297853 |
| 2019 | RHOG Activates RAC1 through CDC42 Leading to Tube Formation in Vascular Endothelial Cells. | Cells | 31 | 30781697 |
| 2009 | Activated Rac1 requires gp130 for Stat3 activation, cell proliferation and migration. | Experimental cell research | 30 | 19852956 |
| 2002 | Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation. | Oncogene | 30 | 11973651 |
| 2018 | RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1. | PLoS genetics | 28 | 29734338 |
| 2005 | Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin. | The Journal of biological chemistry | 28 | 16002401 |
| 2020 | Effect of PAK Inhibition on Cell Mechanics Depends on Rac1. | Frontiers in cell and developmental biology | 27 | 32047750 |
| 2020 | IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation. | Angiogenesis | 27 | 32783108 |
| 2018 | An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction. | Frontiers in molecular neuroscience | 27 | 30042656 |
| 2009 | CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini. | American journal of physiology. Cell physiology | 26 | 19940064 |
| 2020 | Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth. | Developmental cell | 25 | 32533921 |
| 2019 | ASIC1a promotes synovial invasion of rheumatoid arthritis via Ca2+/Rac1 pathway. | International immunopharmacology | 25 | 31865241 |
| 2020 | Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 24 | 31880824 |
| 2020 | Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders. | Neural plasticity | 24 | 33299404 |
| 2013 | The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis. | Developmental biology | 24 | 23872330 |
| 2024 | Implication of Rac1 GTPase in molecular and cellular mitochondrial functions. | Life sciences | 23 | 38387701 |
| 2021 | Mechanistic Differences of Activation of Rac1P29S and Rac1A159V. | The journal of physical chemistry. B | 23 | 33848152 |
| 2017 | Discovery and characterization of small molecule Rac1 inhibitors. | Oncotarget | 23 | 28410221 |
| 2009 | Rac1 signaling modulates BCL-6-mediated repression of gene transcription. | Molecular and cellular biology | 23 | 19487462 |
| 2022 | Two Rac1 pools integrate the direction and coordination of collective cell migration. | Nature communications | 22 | 36224221 |
| 2020 | TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis. | Autophagy | 22 | 32460619 |
| 2018 | Verbascoside Attenuates Rac-1 and HIF-1α Signaling Cascade in Colorectal Cancer Cells. | Anti-cancer agents in medicinal chemistry | 22 | 29886834 |
| 2010 | Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency. | Journal of inherited metabolic disease | 22 | 20814828 |