Affinage

RRBP1

Ribosome-binding protein 1 · UniProt Q9P2E9

Length
1410 aa
Mass
152.5 kDa
Annotated
2026-06-10
100 papers in source corpus 8 papers cited in narrative 8 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RRBP1 (P180) is an endoplasmic reticulum transmembrane ribosome receptor that anchors ribosomes to the ER membrane and organizes local, compartmentalized translation (PMID:38815583). In developing neurons it acts as an axonally distributed ribosome receptor that binds mRNAs encoding axonal membrane proteins and supports their local translation on axonal ER tubules, with RRBP1 disruption causing defects in axon morphology (PMID:38815583). Beyond constitutive ER-ribosome coupling, RRBP1 is mobilized in stress responses: during mitochondrial protein import stress, cytosol-retained NLRX1 recruits RRBP1 to the mitochondrial vicinity, where the NLRX1/RRBP1 complex directs LC3 recruitment and lipidation to drive mitophagosome formation independently of canonical PINK1 signaling (PMID:35752171). RRBP1 also supports cell survival under ER stress, where it enhances GRP78 protein levels and is implicated in stabilizing UPR-component mRNAs, and its overexpression rescues ER-stress-induced apoptosis (PMID:23318453); its abundance is further controlled by the deubiquitinase USP35, which directly binds and deubiquitinates RRBP1 to prevent its proteasomal degradation (PMID:34618999). These pro-survival activities underlie an oncogenic role, including regulation of the Hippo effector YAP1 to confer cisplatin resistance (PMID:33762722). A recurrent RRBP1-ALK gene fusion produces a constitutively active, cytoplasmic/perinuclear ALK oncoprotein in epithelioid inflammatory myofibroblastic sarcoma (PMID:27874193).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2012 Low

    Establishing where RRBP1 resides and that it is broadly upregulated in tumors set the stage for a survival-associated function, but provided no mechanism.

    Evidence Immunohistochemistry of breast carcinoma tissue microarrays with public expression data integration

    PMID:22709790

    Open questions at the time
    • IHC localization only with no functional experiment
    • no mechanistic link between overexpression and tumor phenotype
    • does not address why RRBP1 is elevated
  2. 2013 Medium

    Loss- and gain-of-function in lung cancer cells showed RRBP1 protects cells from ER stress, answering whether its overexpression is functionally consequential by linking it to GRP78 and UPR-component mRNA stability.

    Evidence shRNA knockdown and ectopic overexpression with ER stress agents and viability/IHC assays in lung cancer cells

    PMID:23318453

    Open questions at the time
    • no direct biochemical reconstitution of how RRBP1 enhances GRP78
    • mechanism of mRNA stabilization unresolved
    • single lab
  3. 2016 High

    Identification of a recurrent RRBP1-ALK fusion answered whether RRBP1 contributes to oncogenesis structurally, showing the RRBP1 portion drives a constitutively active, distinctively localized ALK kinase.

    Evidence ALK immunoprecipitation plus mass spectrometry, FISH and IHC across three EIMS tumor cases

    PMID:27874193

    Open questions at the time
    • which RRBP1 domains mediate constitutive ALK activation not dissected
    • downstream signaling of the fusion not characterized
  4. 2016 Medium

    Mapping an IRES in the RRBP1 5' UTR addressed how RRBP1 is translated under stress, showing La-autoantigen-dependent cap-independent initiation that could sustain RRBP1 production when cap-dependent translation is suppressed.

    Evidence IRES reporter assays, RNA pulldown, deletion mapping, and La overexpression/knockdown under drug treatment or serum starvation in hepatocellular carcinoma cells

    PMID:27447629

    Open questions at the time
    • physiological contribution of IRES to RRBP1 protein levels in vivo unquantified
    • link between IRES-driven translation and the survival phenotype not established
  5. 2021 Medium

    Discovery that USP35 deubiquitinates and stabilizes RRBP1 answered how RRBP1 abundance is post-translationally controlled and connected this to ER-stress survival.

    Evidence iTRAQ proteomics, Co-IP, ubiquitination and proteasome-inhibitor assays, KD/OE and apoptosis assays in NSCLC cells

    PMID:34618999

    Open questions at the time
    • E3 ligase opposing USP35 not identified
    • ubiquitination site on RRBP1 not mapped
    • single lab
  6. 2021 Medium

    Linking RRBP1 to YAP1 regulation answered how RRBP1 drives chemoresistance, defining a Hippo-effector axis whose disruption restores drug sensitivity.

    Evidence RNA-seq, proteomics, RRBP1 knockout and pharmacological inhibition (Radezolid), YAP1 analysis and PDC xenografts in OSCC

    PMID:33762722

    Open questions at the time
    • molecular mechanism connecting RRBP1 to YAP1 regulation unresolved
    • whether the link is direct or via translation/ER stress unknown
  7. 2022 High

    Identifying the NLRX1/RRBP1 complex answered how an ER ribosome receptor participates in mitochondrial quality control, defining a PINK1-independent mitophagy route triggered by mitochondrial import stress.

    Evidence Reciprocal Co-IP, RRBP1 relocalization imaging, NLRX1 KO and RRBP1 depletion, LC3 lipidation and in vivo skeletal muscle mitophagy assays

    PMID:35752171

    Open questions at the time
    • how RRBP1 nucleates LC3 lipidation mechanistically unclear
    • structural basis of NLRX1-RRBP1 interaction unknown
  8. 2024 High

    Demonstrating RRBP1 as an axonal ribosome receptor that binds membrane-protein mRNAs established its core physiological function in spatially organizing local translation for axon development.

    Evidence Nanoscale-resolution imaging, ribosome contact mapping, mRNA binding assays, and RRBP1 loss-of-function with axon morphology readouts in rat hippocampal neurons

    PMID:38815583

    Open questions at the time
    • selectivity determinants for which mRNAs RRBP1 binds unresolved
    • whether axonal and stress/cancer functions share the same molecular activity not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RRBP1's ribosome-receptor activity is mechanistically reused across local translation, ER-stress survival, mitophagy, and oncogenic YAP1 signaling remains unresolved.
  • no unifying biochemical mechanism connecting ribosome anchoring to UPR/GRP78 and YAP1 outputs
  • no structural model of RRBP1 domains driving each function
  • direct RNA-binding determinants not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 2 GO:0005198 structural molecule activity 2
Localization
GO:0005783 endoplasmic reticulum 3 GO:0005739 mitochondrion 1
Pathway
R-HSA-1643685 Disease 2 R-HSA-8953897 Cellular responses to stimuli 1 R-HSA-9612973 Autophagy 1
Partners
ALKNLRX1USP35
Complex memberships
NLRX1/RRBP1 complex

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 RRBP1 knockdown by shRNA in lung cancer cells caused ER stress, reduced cell viability and tumorigenicity, and significantly decreased GRP78 protein expression. Ectopic overexpression of RRBP1 alleviated apoptosis induced by ER stress agents (tunicamycin, 2-deoxy-D-glucose, doxorubicin) by enhancing GRP78 protein expression, and RRBP1 was implicated in regulating mRNA stability of UPR components including ATF6 and GRP78. shRNA knockdown, ectopic overexpression, cell viability assays, immunohistochemistry, bioinformatic correlation (GSE10072) Oncogene Medium 23318453
2016 A novel recurrent RRBP1-ALK gene fusion was identified in epithelioid inflammatory myofibroblastic sarcoma. The RRBP1-ALK fusion produced constitutively activated ALK oncoprotein with cytoplasmic/perinuclear ALK localization (distinct from nuclear membranous localization seen with RANBP2-ALK fusions), identified by ALK immunoprecipitation followed by mass spectrometry. ALK immunoprecipitation, mass spectrometry, FISH, immunohistochemistry The Journal of pathology High 27874193
2022 During mitochondrial protein import stress (MPIS), cytosol-retained NLRX1 recruits RRBP1 (a ribosome-binding transmembrane protein of the ER) which relocates to the mitochondrial vicinity. The NLRX1/RRBP1 complex controls LC3 recruitment and lipidation at the site of mitophagosome formation, independently of canonical PINK1 signaling. RRBP1 interaction with NLRX1 was demonstrated and RRBP1 relocation to mitochondrial vicinity during MPIS was documented. Co-immunoprecipitation, subcellular fractionation/live imaging of RRBP1 relocalization, genetic loss-of-function (NLRX1 KO, RRBP1 depletion), LC3 lipidation assays, in vivo skeletal muscle mitophagy assay Molecular cell High 35752171
2021 USP35 (a deubiquitinating enzyme) directly interacts with RRBP1 and prevents its proteasomal degradation by deubiquitination, thereby stabilizing RRBP1. Functionally, USP35 alleviates ER stress-induced apoptosis in non-small cell lung cancer cells through this stabilization of RRBP1. iTRAQ comparative proteomics, Co-immunoprecipitation, ubiquitination assays, proteasome inhibitor treatment, genetic KD/OE, cell apoptosis assays Molecular oncology Medium 34618999
2024 P180/RRBP1 functions as an axonally distributed ribosome receptor in developing rat hippocampal neurons. RRBP1 regulates local mRNA translation on axonal ER tubules and binds to mRNAs enriched for axonal membrane proteins. Impairment of axonal ER-ribosome interactions via RRBP1 disruption causes defects in axon morphology, demonstrating that RRBP1-mediated ER-ribosome contacts are required for proper axon development. Nanoscale resolution imaging, ribosome contact mapping, RRBP1 loss-of-function, mRNA binding assays, axon morphology readouts, live neuron imaging Developmental cell High 38815583
2012 RRBP1 protein is overexpressed in 84% of breast carcinoma cases. Subcellular localization of RRBP1 was predominantly cytoplasmic with intense perinuclear staining, consistent with its ER membrane localization. Immunohistochemical labeling of tissue microarrays (219 breast carcinoma cases), integration with public gene expression databases Clinical proteomics Low 22709790
2021 RRBP1 regulates YAP1 (Yes-associated protein 1), a key effector of the Hippo pathway, to induce cisplatin resistance in oral squamous cell carcinoma. Genetic knockout or pharmacological inhibition (Radezolid) of RRBP1 restored cisplatin-mediated cell death in chemoresistant OSCC cells and reduced tumor burden in PDC xenografts. RNA sequencing, global proteomic profiling, RRBP1 knockout, pharmacological inhibition, PDC xenograft experiments, YAP1 expression analysis British journal of cancer Medium 33762722
2016 The 5' UTR of RRBP1 mRNA contains an internal ribosome entry site (IRES). La autoantigen binds to the RRBP1 IRES element and facilitates cap-independent translation initiation under cellular stress conditions (chemotherapeutic drug treatment or serum starvation). Two apical GARR loops within the IRES are important for La binding. The core IRES activity was mapped to nucleotides -237 to -58. IRES reporter assays, RNA pulldown/binding assays, deletion mapping, La overexpression and knockdown, stress induction experiments in hepatocellular carcinoma cells International journal of molecular sciences Medium 27447629

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 HES and HERP families: multiple effectors of the Notch signaling pathway. Journal of cellular physiology 1019 12548545
2000 Control of endodermal endocrine development by Hes-1. Nature genetics 930 10615124
2005 Low O2 tensions and the prevention of differentiation of hES cells. Proceedings of the National Academy of Sciences of the United States of America 652 15772165
2007 The Hes gene family: repressors and oscillators that orchestrate embryogenesis. Development (Cambridge, England) 522 17329370
2004 Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development (Cambridge, England) 459 15496443
2004 Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nature cell biology 352 15156153
1994 Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system. The EMBO journal 339 7909512
2007 Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic acids research 311 17586813
1999 The Notch-Hes pathway in mammalian neural development. Cell research 275 10520600
1997 Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proceedings of the National Academy of Sciences of the United States of America 240 9144241
2008 Roles of Hes genes in neural development. Development, growth & differentiation 236 18430159
2000 Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Development (Cambridge, England) 191 10804175
2001 HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Molecular and cellular biology 187 11486045
2000 A role for pref-1 and HES-1 in thymocyte development. Journal of immunology (Baltimore, Md. : 1950) 164 10605019
2004 Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Molecular and cellular biology 129 15060169
2001 The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. Molecular and cellular biology 110 11238932
2008 Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PloS one 109 19050759
2012 The role of Hes genes in intestinal development, homeostasis and tumor formation. Development (Cambridge, England) 108 22318232
2016 ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma. The Journal of pathology 107 27874193
2012 Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. The Journal of experimental medicine 102 23267012
1995 Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element. The Journal of biological chemistry 98 7836401
2008 Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney international 90 18418349
2025 Phase I trial of hES cell-derived dopaminergic neurons for Parkinson's disease. Nature 85 40240592
2013 Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78. Oncogene 84 23318453
2014 Expression dynamics and functions of Hes factors in development and diseases. Current topics in developmental biology 83 25248479
2006 Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cells. Laboratory investigation; a journal of technical methods and pathology 82 16732296
2011 Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Developmental biology 81 21300049
2013 Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage. Human molecular genetics 77 24087792
2009 Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. International journal of oncology 76 19513567
2012 The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma. Carcinogenesis 71 22871495
2018 Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS biology 63 29389974
2008 HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro. Diabetes 59 18599525
2022 Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1. Molecular cell 58 35752171
1999 Regulation of hippocampal neuronal differentiation by the basic helix-loop-helix transcription factors HES-1 and MASH-1. Journal of neuroscience research 55 10336252
2015 Activation of OR1A1 suppresses PPAR-γ expression by inducing HES-1 in cultured hepatocytes. The international journal of biochemistry & cell biology 54 25817041
2004 HES-1, a novel target gene for the aryl hydrocarbon receptor. Molecular pharmacology 54 14722248
2011 Notch2/Hes-1 pathway plays an important role in renal ischemia and reperfusion injury-associated inflammation and apoptosis and the γ-secretase inhibitor DAPT has a nephroprotective effect. Renal failure 53 21332343
2006 Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent Hes genes in the developing nervous system. Cerebral cortex (New York, N.Y. : 1991) 53 16766699
2017 Activation of STAT3/HIF-1α/Hes-1 axis promotes trastuzumab resistance in HER2-overexpressing breast cancer cells via down-regulation of PTEN. Biochimica et biophysica acta. General subjects 51 28499822
2004 HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1. Oncogene 51 15467735
2012 Controlled shielding and deshielding of gene delivery polyplexes using hydroxyethyl starch (HES) and alpha-amylase. Journal of controlled release : official journal of the Controlled Release Society 50 22269664
2000 Induced neuroblastoma cell differentiation, associated with transient HES-1 activity and reduced HASH-1 expression, is inhibited by Notch1. International journal of cancer 50 11054669
2017 Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation. Development (Cambridge, England) 48 28974640
2014 Dynamic expression and roles of Hes factors in neural development. Cell and tissue research 48 24850276
2013 Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia. PloS one 48 23637910
2009 Notch signaling and Hes labeling in the normal and drug-damaged organ of Corti. Hearing research 47 19185606
2017 Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Neurogenesis (Austin, Tex.) 46 28573150
2004 The Notch signaling cascade in neuroblastoma: role of the basic helix-loop-helix proteins HASH-1 and HES-1. Cancer letters 46 15013216
2005 Functional analysis of Hes-1 in preadipocytes. Molecular endocrinology (Baltimore, Md.) 44 16282371
2009 HES 130/0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function. Critical care (London, England) 42 20028511
2006 The development of 'feeder' cells for the preparation of clinical grade hES cell lines: challenges and solutions. Journal of biotechnology 41 16690155
2002 The anti-estrogenic effect of all-trans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1 expression. The Journal of biological chemistry 41 12080040
2001 Bovine coronaviruses associated with enteric and respiratory diseases in Canadian dairy cattle display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein. Virus research 40 11376845
2016 Co-inhibition of Notch and NF-κB Signaling Pathway Decreases Proliferation through Downregulating IκB-α and Hes-1 Expression in Human Ovarian Cancer OVCAR-3 Cells. Drug research 39 27684192
1999 A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development. Cellular and molecular biology (Noisy-le-Grand, France) 39 10512199
2011 Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism. Biochimica et biophysica acta 37 22036964
2010 ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors. Journal of neurochemistry 37 20067572
2009 Functional characterization of PAS and HES family bHLH transcription factors during the metamorphosis of the red flour beetle, Tribolium castaneum. Gene 37 19683038
2016 Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus. Cell death & disease 35 27537524
2021 USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer. Molecular oncology 33 34618999
2014 The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes. Seminars in cell & developmental biology 33 24865153
2024 Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions. Developmental cell 32 38815583
2005 Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway. Journal of immunology (Baltimore, Md. : 1950) 32 15728456
2014 Differential regulation of Hes/Hey genes during inner ear development. Developmental neurobiology 31 25363712
2008 And Lophotrochozoa makes three: Notch/Hes signaling in annelid segmentation. Development genes and evolution 31 19011897
2023 HES and EGPA: Two Sides of the Same Coin. Mayo Clinic proceedings 30 37419574
2009 The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells. Journal of cellular biochemistry 30 19670267
2012 JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1. The Journal of neuroscience : the official journal of the Society for Neuroscience 29 22302822
2006 Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochemical and biophysical research communications 29 16682003
2020 The Beneficial Effect of HES on Vascular Permeability and Its Relationship With Endothelial Glycocalyx and Intercellular Junction After Hemorrhagic Shock. Frontiers in pharmacology 28 32457611
2015 Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathway. Medical oncology (Northwood, London, England) 28 25920606
2012 Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer. Clinical proteomics 27 22709790
2012 miR-1-mediated induction of cardiogenesis in mesenchymal stem cells via downregulation of Hes-1. BioMed research international 27 23509692
2001 Altered expression of HES-1, BETA2/NeuroD, and PDX-1 is involved in impaired insulin synthesis induced by glucocorticoids in HIT-T15 cells. Biochemical and biophysical research communications 27 11549279
2012 Comparative and evolutionary analysis of the HES/HEY gene family reveal exon/intron loss and teleost specific duplication events. PloS one 26 22808219
2009 Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. Breast cancer research : BCR 26 19891787
2023 Investigation of He's Yang Chao recipe against oxidative stress-related mitophagy and pyroptosis to improve ovarian function. Frontiers in endocrinology 25 36777359
2020 Syndecan-4-/- Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components. Frontiers in cell and developmental biology 25 32850844
2011 The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis. Development (Cambridge, England) 25 21486924
1994 Structure and chromosomal locus of the mouse gene encoding a cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3. Biochemical and biophysical research communications 25 8074710
2022 CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1. Oncogene 24 35091683
2016 Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress by suppressing abnormal testicular matrix metalloproteinase system via the Notch 2/Jagged 1/Hes-1 and caspase-8 pathways. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 24 27010902
2014 E(spl): genetic, developmental, and evolutionary aspects of a group of invertebrate Hes proteins with close ties to Notch signaling. Current topics in developmental biology 24 25248478
2014 History of a prolific family: the Hes/Hey-related genes of the annelid Platynereis. EvoDevo 24 25250171
2021 RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway. British journal of cancer 23 33762722
2012 PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: possible implications for sclerosing cholangitis. Journal of hepatology 23 23207146
2021 The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation. Cellular & molecular biology letters 22 33622250
2021 Rutin Mediated Apoptotic Cell Death in Caski Cervical Cancer Cells via Notch-1 and Hes-1 Downregulation. Life (Basel, Switzerland) 22 34440505
2021 LncRNA SNHG7 Regulates Mesenchymal Stem Cell Through the Notch1/Jagged1/Hes-1 Signaling Pathway and Influences Folfirinox Resistance in Pancreatic Cancer. Frontiers in oncology 22 34631547
2013 The jagged-2/notch-1/hes-1 pathway is involved in intestinal epithelium regeneration after intestinal ischemia-reperfusion injury. PloS one 22 24098462
2014 Discovery of HeLa Cell Contamination in HES Cells: Call for Cell Line Authentication in Reproductive Biology Research. Reproductive sciences (Thousand Oaks, Calif.) 21 24520087
2011 Expression of HES and HEY genes in infantile hemangiomas. Vascular cell 21 21834989
2002 Characterization of the transcriptional expression of Notch-1 signaling pathway members, Deltex and HES-1, in developing mouse thymocytes. Developmental and comparative immunology 21 12031417
2016 La Autoantigen Induces Ribosome Binding Protein 1 (RRBP1) Expression through Internal Ribosome Entry Site (IRES)-Mediated Translation during Cellular Stress Condition. International journal of molecular sciences 20 27447629
2004 Cell cycle-dependent expression of a hairy and Enhancer of split (hes) homolog during cleavage and segmentation in leech embryos. Developmental biology 20 15081366
2022 Liraglutide ameliorates gentamicin-induced acute kidney injury in rats via PGC-1α- mediated mitochondrial biogenesis: Involvement of PKA/CREB and Notch/Hes-1 signaling pathways. International immunopharmacology 19 36525794
2008 Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection. AIDS research and therapy 18 18215326
2002 The human acid alpha-glucosidase gene is a novel target of the Notch-1/Hes-1 signaling pathway. The Journal of biological chemistry 18 12065598
2021 Multiple functions of Hes genes in the proliferation and differentiation of neural stem cells. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 17 34715307
2010 Spatially resolved quantification of E-cadherin on target hES cells. The journal of physical chemistry. B 17 20131884

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