Affinage

RPS18

Small ribosomal subunit protein uS13 · UniProt P62269

Length
152 aa
Mass
17.7 kDa
Annotated
2026-06-10
53 papers in source corpus 20 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS18 (uS13) is a core protein of the ribosomal small subunit (30S/40S) that assembles cooperatively onto the central domain of small-subunit rRNA, where it contributes to organizing the mRNA decoding environment (PMID:10753109, PMID:6208366). Its incorporation is strictly hierarchical: S15 binds rRNA first and reorganizes two three-helix junctions to create the fold required for the subsequent cooperative binding of an S6:S18 heterodimer, which alone has negligible rRNA affinity but binds with sub-nanomolar affinity once S15 is bound (PMID:10753109, PMID:11601845). Within the assembled subunit, S18 contacts the central domain of 16S rRNA (principally the 825–858 region) and lies near the P-site and mRNA channel, with its cysteine-10 forming part of the mRNA-binding site such that this residue can be cross-linked by an mRNA-mimetic AUG analog that blocks fMet-tRNA P-site binding (PMID:2459389, PMID:3373530, PMID:2449359, PMID:2437528, PMID:365533). Beyond its structural role, the same S6:S18 heterodimer functions as an autoregulatory RNA-binding effector: it recognizes a conserved CCG-bearing motif in the 5'-UTR of rpsF–rpsR operons that mimics its 16S rRNA binding site, repressing rpsF translation and lowering transcript levels (PMID:23980204, PMID:26447183). In bacteria S18 is N-terminally acetylated on its N-terminal alanine by the acetyltransferase RimI through a defined addition–elimination mechanism (PMID:2828880, PMID:6991870, PMID:18596200). Reduced dosage of the small-subunit ribosomal protein gene in yeast modulates cytoplasmic translational fidelity, acting indirectly rather than through mitochondrial localization (PMID:8070651).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1978 Medium

    Established that S18 lies at the functional heart of the small subunit by placing a specific residue, cysteine-10, within the mRNA-binding site adjacent to the tRNA binding region.

    Evidence affinity cross-linking with a reactive AUG analog and peptide analysis in E. coli ribosomes

    PMID:365533

    Open questions at the time
    • Single-method chemical cross-linking
    • Does not resolve whether contact is direct mRNA binding or proximity within the channel
  2. 1979 Medium

    Confirmed that cysteine-10 of S18 is solvent-accessible and functionally near the mRNA path, enabling its use as a reporter of mRNA-ribosome interaction.

    Evidence site-specific fluorescent labeling of 30S subunits and mRNA-binding fluorescence quenching assay

    PMID:376533

    Open questions at the time
    • Indirect functional inference from fluorescence
    • Single lab
  3. 1984 High

    Defined the hierarchical assembly logic of the central domain, showing S18 incorporation depends on prior S8 and S15 binding and that the proteins together protect a discrete rRNA region.

    Evidence binding dependency assays and RNase protection of reconstituted RNP complexes

    PMID:6208366

    Open questions at the time
    • Bacterial system only
    • No atomic-resolution structure at this stage
  4. 1987 High

    Identified the enzyme and specificity of S18 N-terminal modification, establishing RimI as the dedicated acetyltransferase for the S18 N-terminal alanine.

    Evidence rimI cloning, insertional mutagenesis, and N-terminal sequencing of wild-type vs mutant S18 in E. coli

    PMID:2828880 PMID:6991870

    Open questions at the time
    • Functional consequence of S18 acetylation for translation not addressed
  5. 1988 High

    Mapped S18 contacts on 16S rRNA and confirmed cooperative S6/S18 binding dependent on S15, localizing the proteins near P-site nucleotides.

    Evidence chemical/enzymatic rRNA probing in reconstituted complexes and Pt(II) RNA-protein cross-linking

    PMID:2449359 PMID:2459389 PMID:3373530

    Open questions at the time
    • Resolution limited to rRNA regions, not individual contacts
  6. 2000 High

    Resolved the molecular basis of cooperative assembly, showing S15 binding reorganizes rRNA helix junctions to template subsequent S6 and S18 binding.

    Evidence 2.6 Å X-ray crystallography of the S15-S6-S18-rRNA complex from T. thermophilus

    PMID:10753109

    Open questions at the time
    • Thermophile structure; eukaryotic 40S assembly not directly addressed
  7. 2001 High

    Quantified the thermodynamics of assembly, demonstrating S6 and S18 form a stable heterodimer that requires S15 to gain rRNA affinity.

    Evidence isothermal titration calorimetry and gel mobility shift with A. aeolicus proteins

    PMID:11601845

    Open questions at the time
    • Single lab
    • Bacterial proteins only
  8. 2008 High

    Elucidated the catalytic chemistry of S18 N-acetylation, defining the RimI active-site mechanism.

    Evidence X-ray crystallography of RimI with CoA/AcCoA/bisubstrate inhibitor and steady-state kinetics with S18 peptide

    PMID:18596200

    Open questions at the time
    • In vivo consequence of the modification for ribosome function not tested
  9. 2013 Medium

    Revealed that the S6:S18 heterodimer is an RNA recognition module beyond the ribosome, binding a conserved 5'-UTR motif resembling its rRNA site.

    Evidence computational motif identification, in vitro binding, mutagenesis, and structural modeling

    PMID:23980204

    Open questions at the time
    • No quantitative binding affinities
    • Single lab
  10. 2015 Medium

    Established the autoregulatory function of S18, showing the S6:S18 heterodimer represses rpsF translation and transcript levels via the 5'-UTR.

    Evidence lacZ reporter fusions to rpsF 5'-UTR, overexpression, transcript quantification, and mutagenesis in E. coli

    PMID:26447183

    Open questions at the time
    • Mechanism of the transcript-level effect not resolved
    • Single lab
  11. 2022 Medium

    Broadened the role of the S18 modification writer RimI, showing it also acetylates EF-Tu to enhance A-site tRNA delivery.

    Evidence in vitro aminoacyl-tRNA binding, fast-kinetics A-site occupation, and translation assays

    PMID:35398352

    Open questions at the time
    • Concerns RimI substrate scope, not S18 function directly
    • Single lab
  12. 2002 Low

    Proposed a eukaryote-specific regulatory input by identifying human S18 as a CaMKII substrate linked to protein synthesis.

    Evidence co-immunoprecipitation, phosphorylation in vascular smooth muscle cells, and pharmacological CaMKII inhibition

    PMID:12145273

    Open questions at the time
    • Single Co-IP without reconstituted kinase assay
    • Phosphosite not mapped
    • Causal link to translation indirect
  13. 2004 Low

    Suggested an extraribosomal interaction by identifying human S18 as a cofilin-binding partner mapping to cofilin's actin-binding site.

    Evidence phage display screen, His-tag pulldown, and FLAG-S18 co-immunoprecipitation in COS-7 cells

    PMID:15532723

    Open questions at the time
    • No reciprocal endogenous validation
    • Functional significance unknown
  14. 2025 Low

    Implicated RPS18 in viral protein synthesis through recruitment to viral dsRNA by DDX21 in a self-amplifying loop.

    Evidence co-localization, interaction assays, siRNA knockdown, and viral protein dose-response during CSFV infection

    PMID:41337972

    Open questions at the time
    • Single study with limited mechanistic detail
    • No orthogonal validation described
    • Direct vs ribosome-mediated effect not separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether eukaryotic post-translational modifications and extraribosomal partners of RPS18 (CaMKII phosphorylation, cofilin binding, DDX21-mediated viral recruitment) reflect bona fide regulatory functions distinct from its core ribosomal role remains unresolved.
  • No structural or reconstituted basis for eukaryotic modifications
  • Phosphosite/acetylation status in eukaryotes uncharacterized
  • Mechanistic link between extraribosomal interactions and translation undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0005198 structural molecule activity 3 GO:0045182 translation regulator activity 2
Localization
GO:0005840 ribosome 4
Pathway
R-HSA-392499 Metabolism of proteins 3
Partners
CAMK2DCFL1DDX21RIMIRPS15RPS6
Complex memberships
30S/40S ribosomal small subunitS15-S6-S18-rRNA assembly complexS6:S18 heterodimer

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Crystal structure of the S15-S6-S18-rRNA complex from Thermus thermophilus 30S subunit central domain revealed that S15 binds rRNA first, inducing a conformational reorganization of two three-helix junctions that creates the RNA fold necessary for subsequent cooperative binding of S6 and S18. X-ray crystallography at 2.6 Å resolution Science High 10753109
1988 Chemical probing of 16S rRNA in reconstituted complexes showed that S6 and S18 binding is cooperative and dependent on prior binding of S15; S6, S18, and S11 interact with the 690-720 and 790 loop regions of 16S rRNA near P-site nucleotides. Chemical probing of rRNA with structure-specific probes in reconstituted protein-rRNA complexes Journal of molecular biology High 2459389 3373530
1984 Cooperative assembly of S6, S8, S15, and S18 with 16S rRNA was dissected: S8 and S15 bind independently; S18 binding requires S8 and S15; S6 binding requires S8, S15, and S18. Together they protect the entire central domain (nucleotides 560–890) of 16S rRNA. Binding dependency assays and RNase protection of reconstituted ribonucleoprotein complexes; gel electrophoresis and centrifugation fractionation Journal of molecular biology High 6208366
2001 S6 and S18 form a stable heterodimer in solution (Kd ~8.7 nM) that binds cooperatively to the S15-rRNA complex (Kd ~2.7 nM). Presence of S15 increases S6:S18 affinity for RNA by at least four orders of magnitude. S6 or S18 alone do not bind rRNA. Isothermal titration calorimetry and gel mobility shift assays with Aquifex aeolicus proteins Journal of molecular biology High 11601845
1987 The rimI gene of E. coli encodes an N-terminal acetyltransferase that specifically acetylates the N-terminal alanine of ribosomal protein S18; mutation in rimI abolishes S18 acetylation without affecting S5 or L12 acetylation. Gene cloning, insertional mutagenesis, N-terminal amino acid sequence analysis of wild-type and mutant S18 Molecular & general genetics High 2828880 6991870
2008 Crystal structure of RimI from Salmonella typhimurium in complex with CoA, AcCoA, and a bisubstrate inhibitor (CoA-S-acetyl-ARYFRR) reveals a direct nucleophilic addition-elimination mechanism for N-alpha-acetylation of S18, with Glu103 as the catalytic base and Tyr115 as the catalytic acid. X-ray crystallography of RimI complexes; steady-state kinetics with S18 peptide substrate Protein science High 18596200
1978 Affinity labeling with a chemically reactive AUG analog cross-linked exclusively to protein S18 at cysteine-10, inhibiting fMet-tRNA binding to the P-site and stimulating elongation-factor-dependent Met-tRNA binding; implicating S18 cysteine-10 as part of the mRNA-binding site near the aminoacyl-tRNA binding site of E. coli ribosomes. Affinity cross-linking with bromoacetamidophenyl-AUG analog; peptide and amino acid analysis European journal of biochemistry Medium 365533
1979 Fluorescent labeling of E. coli 30S ribosomes with IAEDANS attached specifically to cysteine-10 of S18; the labeled ribosomes are fully active, and fluorescence quenching upon mRNA binding provides a direct assay for mRNA-ribosome interaction. Fluorescent dye conjugation, competitive N-ethylmaleimide labeling, mRNA binding fluorescence assay The Journal of biological chemistry Medium 376533
1988 RNA-protein cross-linking with trans-diamminedichloroplatinum(II) in E. coli 30S subunits identified three cross-linking sites for S18 on 16S rRNA: a major site at region 825-858, and two minor sites at regions 434-500 and 233-297. Reversible RNA-protein cross-linking followed by nuclease digestion and protein identification FEBS letters Medium 2449359
1987 RNA-protein cross-linking in E. coli 30S subunits placed the S18 cross-link site at positions 845-851 of 16S rRNA. Chemical cross-linking with bis-(2-chloroethyl)-methylamine followed by nuclease digestion and protein/RNA analysis Nucleic acids research Medium 2437528
1993 Immune electron microscopy of DNP-S18 incorporated into reconstituted E. coli 30S subunits localized S18 to the subunit platform below the tip, in a region associated with 50S subunit binding. Dinitrophenylation of S18, reconstitution into 30S subunits, immune electron microscopy with anti-DNP antibodies The Journal of biological chemistry Medium 8360163
2013 The S6:S18 heterodimer binds a conserved RNA motif (S6S18CBM) in the 5' UTR of rpsF-rpsR operons across many bacterial phyla; the binding site contains a CCG trinucleotide in a bulge flanked by stem and hairpin, resembling the S18 binding site in 16S rRNA. Site-directed mutagenesis of both RNA and protein components confirmed specificity of recognition. Computational RNA motif identification, in vitro binding assays, site-directed mutagenesis, 3D structural modeling RNA Medium 23980204
2015 In E. coli, the S6:S18 heterodimer (not either protein alone) acts as the biologically active effector to inhibit translation of rpsF via the 5' UTR RNA structure; mutations in the S18 RNA-binding site and in S6-S18 interaction surfaces derepress translation. This suppression also reduces native rpsF transcript levels, suggesting a dual translational and transcript-level regulatory effect. β-galactosidase reporter assay with lacZ fused to rpsF 5' UTR; protein overexpression; mRNA quantification; site-directed mutagenesis RNA Medium 26447183
2002 The S18 protein of the human 40S ribosomal subunit was identified as a substrate for CaMKII-delta in vascular smooth muscle cells; S18 co-immunoprecipitated with CaMKII, was phosphorylated in response to serum treatment, and this phosphorylation was blocked by CaMKII inhibitor KN-93, which also reduced protein synthesis by ~24%. Co-immunoprecipitation, affinity purification, protein sequencing, pharmacological inhibition, protein synthesis measurement The Journal of biological chemistry Low 12145273
2004 Human ribosomal protein S18 was identified as a cofilin-binding protein; the C-terminal half of S18 was sufficient for cofilin binding (phage display), S18 co-eluted with cofilin from Ni-NTA beads, and cofilin co-immunoprecipitated with FLAG-S18 in COS-7 cells; binding was abrogated by actin pre-incubation with cofilin, mapping the interaction to cofilin's actin-binding site. Phage display cDNA library screen, pulldown with His-tagged S18, co-immunoprecipitation of FLAG-S18 in COS-7 cells Molecular and cellular biochemistry Low 15532723
2022 RimI acetyltransferase (known to N-terminally acetylate S18) is also responsible for N-terminal acetylation of elongation factor Tu (EF-Tu) in E. coli; acetylation of EF-Tu does not affect its stability or aminoacyl-tRNA binding in vitro, but acetylated EF-Tu more efficiently accelerates A-site occupation by aminoacyl-tRNA in fast-kinetics assays, increasing in vitro translation efficiency. Inducible tufA expression, in vitro aminoacyl-tRNA binding assay, fast kinetics of A-site occupation, in vitro translation assay The Journal of biological chemistry Medium 35398352
2025 During CSFV infection, DDX21 translocates from nucleus to cytoplasm and recruits RPS18 onto viral dsRNA; RPS18 dose-dependently enhances viral NS4A protein synthesis; DDX21's pro-viral activity is strictly RPS18-dependent; DDX21 upregulates RPS18 via its helicase domain while RPS18 suppresses DDX21 levels, forming a self-amplifying regulatory loop. Co-localization, protein interaction assays, siRNA knockdown, viral protein synthesis measurement, dose-response analysis Veterinary microbiology Low 41337972
1994 In S. cerevisiae, reduced dosage of RPS18A (one of two genes encoding cytoplasmic small subunit ribosomal protein S18) partially suppressed a mitochondrial COX3 translation initiation codon mutation; suppression correlated with limitation of small ribosomal subunits and was allele-specific, suggesting an indirect effect through altered cytoplasmic translational accuracy or product levels rather than direct mitochondrial localization of S18 (epitope-tagged S18 was not detected in mitochondria). Genetic epistasis, null and missense mutant construction, epitope-tag localization, paromomycin sensitivity assays Genetics Medium 8070651

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain. Science (New York, N.Y.) 174 10753109
2006 Tobacco plastid ribosomal protein S18 is essential for cell survival. Nucleic acids research 128 16945948
1987 Cloning and nucleotide sequencing of the genes rimI and rimJ which encode enzymes acetylating ribosomal proteins S18 and S5 of Escherichia coli K12. Molecular & general genetics : MGG 126 2828880
1988 Interaction of ribosomal proteins S5, S6, S11, S12, S18 and S21 with 16 S rRNA. Journal of molecular biology 94 2459389
1988 Interaction of ribosomal proteins, S6, S8, S15 and S18 with the central domain of 16 S ribosomal RNA. Journal of molecular biology 88 3373530
2008 Crystal structure of RimI from Salmonella typhimurium LT2, the GNAT responsible for N(alpha)-acetylation of ribosomal protein S18. Protein science : a publication of the Protein Society 77 18596200
1986 Drosophila chorion gene amplification requires an upstream region regulating s18 transcription. Molecular and cellular biology 67 3099171
1984 Interaction of ribosomal proteins S6, S8, S15 and S18 with the central domain of 16 S ribosomal RNA from Escherichia coli. Journal of molecular biology 61 6208366
1977 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. The Journal of biological chemistry 60 925037
1987 RNA-protein cross-linking in Escherichia coli 30S ribosomal subunits; determination of sites on 16S RNA that are cross-linked to proteins S3, S4, S7, S9, S10, S11, S17, S18 and S21 by treatment with bis-(2-chloroethyl)-methylamine. Nucleic acids research 54 2437528
1980 Ribosomal protein modification in Escherichia coli. II. Studies of a mutant lacking the N-terminal acetylation of protein S18. Molecular & general genetics : MGG 49 6991870
2001 Central domain assembly: thermodynamics and kinetics of S6 and S18 binding to an S15-RNA complex. Journal of molecular biology 47 11601845
2015 Zinc regulates a switch between primary and alternative S18 ribosomal proteins in Mycobacterium tuberculosis. Molecular microbiology 44 25858183
1991 A 15-kilobase-pair region of the human cytomegalovirus genome which includes US1 through US13 is dispensable for growth in cell culture. Journal of virology 42 1654438
1986 The nucleotide sequence of an Escherichia coli chromosomal region containing the genes for ribosomal proteins S6, S18, L9 and an open reading frame. Molecular & general genetics : MGG 32 3528756
1990 Evolution of the autosomal chorion cluster in Drosophila. III. Comparison of the s18 gene in evolutionarily distant species and heterospecific control of chorion gene amplification. Journal of molecular biology 27 2213881
1994 Reduced dosage of genes encoding ribosomal protein S18 suppresses a mitochondrial initiation codon mutation in Saccharomyces cerevisiae. Genetics 25 8070651
1978 Cluster of ribosomal protein genes in Escherichia coli containing genes for proteins S6, S18, and L9. Proceedings of the National Academy of Sciences of the United States of America 24 366612
2020 Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2. Proceedings of the National Academy of Sciences of the United States of America 20 32571933
2016 Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1. Oncotarget 20 26959119
2011 Proteomic profiling between CNE-2 and its strongly metastatic subclone S-18 and functional characterization of HSP27 in metastasis of nasopharyngeal carcinoma. Proteomics 20 21717573
2019 Screening and optimizing fermentation production of l-asparaginase by Aspergillus terreus strain S-18 isolated from the Brazilian Caatinga Biome. Journal of applied microbiology 17 30762925
2015 Versatile properties of an exopolysaccharide R-PS18 produced by Rhizobium sp. PRIM-18. Carbohydrate polymers 16 25933542
2013 S6:S18 ribosomal protein complex interacts with a structural motif present in its own mRNA. RNA (New York, N.Y.) 16 23980204
1979 A fluorescent derivative of ribosomal protein S18 which permits direct observation of messenger RNA binding. The Journal of biological chemistry 16 376533
2015 An S6:S18 complex inhibits translation of E. coli rpsF. RNA (New York, N.Y.) 15 26447183
2013 Bacterial RNA motif in the 5' UTR of rpsF interacts with an S6:S18 complex. RNA (New York, N.Y.) 15 24310371
2021 Amphioxus ribosomal proteins RPS15, RPS18, RPS19 and RPS30-precursor act as immune effectors via killing or agglutinating bacteria. Fish & shellfish immunology 14 34487827
2018 Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorganic & medicinal chemistry letters 14 30301676
2015 Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts. Oncotarget 14 26023799
2022 Ribosomal protein S18 acetyltransferase RimI is responsible for the acetylation of elongation factor Tu. The Journal of biological chemistry 13 35398352
1978 Identification of cysteine-10 of protein S18 as part of the mRNA-binding site of Escherichia coli ribosomes by affinity-labeling studies with a chemically reactive A-U-G analog. European journal of biochemistry 13 365533
1977 Further evidence that the ribosomal 30S proteins S3, S5, S9, S11, S12, and S18 possess specific 16S RNA binding sites. Molecular & general genetics : MGG 13 331074
1991 The primary structure of rat ribosomal protein S18. Biochemical and biophysical research communications 12 1872840
1988 Crosslinking of ribosomal protein S18 to 16 S RNA in E.coli ribosomal 30 S subunits by the use of a reversible crosslinking agent: trans-diamminedichloroplatinum(II). FEBS letters 12 2449359
2016 S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma. Oncotarget 10 27489352
2002 The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. The Journal of biological chemistry 10 12145273
2021 40S ribosomal protein S18 is a novel maternal peptidoglycan-binding protein that protects embryos of zebrafish from bacterial infections. Developmental and comparative immunology 9 34310970
2014 Molecular characterization of the complete genome of falconid herpesvirus strain S-18. Virus research 9 24685675
2009 Structural motifs of the bacterial ribosomal proteins S20, S18 and S16 that contact rRNA present in the eukaryotic ribosomal proteins S25, S26 and S27A, respectively. Nucleic acids research 9 20034956
1993 Placement of dinitrophenyl-modified ribosomal proteins in totally reconstituted Escherichia coli 30 S subunits. Localization of proteins S6, S13, S16, and S18 by immune electron microscopy. The Journal of biological chemistry 8 8360163
1994 The Drosophila melanogaster homolog of ribosomal protein S18. Gene 7 8163194
2001 The chorion genes of the medfly. II. DNA sequence evolution of the autosomal chorion genes s18, s15, s19 and s16 in Diptera. Gene 6 11404001
1992 Positive and negative DNA elements of the Drosophila grimshawi s18 chorion gene assayed in Drosophila melanogaster. Developmental biology 6 1628750
2004 Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. Molecular and cellular biochemistry 5 15532723
2018 Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas. Experimental oncology 4 30593750
1989 Crosslinking of ribosomal proteins S4, S5, S7, S8, S11, S12 and S18 to domains 1 and 2 of 16S rRNA in the Escherichia coli 30S particle. Biochimie 4 2505863
1998 The cloning and sequencing of ribosomal protein S18 of parasitic protozoa, Entamoeba histolytica. DNA sequence : the journal of DNA sequencing and mapping 3 10520458
2024 Evaluation of the biological function of ribosomal protein S18 from cattle tick Rhipicephalus microplus. Ticks and tick-borne diseases 2 38522220
1993 Incorporation of dinitrophenyl derivatives of proteins S6, S13, S16, and S18 into the 30 S subunit of Escherichia coli ribosomes by total reconstitution. The Journal of biological chemistry 2 7689558
1989 The complete amino acid sequence of ribosomal protein S18 from the moderate thermophile Bacillus stearothermophilus. FEBS letters 2 2647521
2025 DDX21 nuclear-cytoplasmic shuttling recruits RPS18 to viral dsRNA to promote CSFV replication. Veterinary microbiology 0 41337972
1998 Nucleotide sequence of a three gene cluster in Neisseria Gonorrhoeae encoding ribosomal proteins S6, S18, and L9. DNA sequence : the journal of DNA sequencing and mapping 0 10524762

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