Affinage

RPL29

Large ribosomal subunit protein eL29 · UniProt P47914

Length
159 aa
Mass
17.8 kDa
Annotated
2026-06-10
53 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL29 (eL29) is a component of the large (60S/50S) ribosomal subunit that facilitates ribosomal subunit assembly and joining and modulates the rate of global protein synthesis (PMID:11997090, PMID:17195189). Within the ribosome it sits at the exit of the polypeptide tunnel, where it can undergo nascent-chain-induced conformational changes (PMID:29605910), and it contacts neighboring large-subunit proteins and rRNA (PMID:6170935, PMID:6468376, PMID:8444837). Yeast RPL29 carries internal nuclear-localizing sequences whose basic residues are required for both nuclear import and ribosome assembly (PMID:2104804), and its loss produces half-mer polysomes reflecting defective 60S subunit joining, genetically linked to the RPL10/RSA1 assembly axis (PMID:11997090). Loss of RPL29 in mice causes global growth retardation with reduced proliferation, lowered protein synthesis, and decreased steady-state levels of core ribosomal proteins (PMID:17195189). The protein is post-translationally methylated at Lys5 exclusively by Set7/9 and demethylated by Lsd1/Kdm1a, a modification that controls its subcellular localization without altering global translation (PMID:29959229), and it autoregulates its own synthesis by binding the 3' coding region of its cognate mRNA in a manner mimicking its rRNA contact site (PMID:32798643). Beyond the ribosome, RPL29 (HIP) acts as a peripheral membrane heparin/heparan sulfate-binding protein whose multiple binding domains undergo a conformational change upon heparin binding (PMID:9737974, PMID:11123893); through this activity it antagonizes VEGF- and FGF2-driven signaling by displacing growth factors from heparan sulfate and inhibiting heparanase, thereby restraining angiogenesis in vivo and opposing cellular differentiation (PMID:18980226, PMID:23118343, PMID:16475173, PMID:12919102).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1982 Medium

    Genetic and biochemical work established that the yeast cycloheximide-resistance locus encodes a single-copy large-subunit ribosomal protein, defining L29/RPL29 as a bona fide 60S component and target of cycloheximide.

    Evidence 2D gel electrophoresis of mutant ribosomal proteins, genetic co-segregation, and molecular cloning of CYH2 in yeast

    PMID:24189656 PMID:6285288

    Open questions at the time
    • Does not define the protein's structural position or assembly function
    • Mechanism of cycloheximide resistance at the residue level not established
  2. 1985 Medium

    Cross-linking and immunoelectron microscopy positioned the protein on the large subunit surface and its rRNA/protein neighborhood, providing the first structural placement.

    Evidence RNA-protein and protein-protein cross-linking and immuno-EM localization in bacterial and mammalian large subunits

    PMID:3926498 PMID:6170935 PMID:6468376 PMID:8444837

    Open questions at the time
    • Surface/back placement from EM predates atomic structures and the exit-tunnel assignment
    • Functional consequence of these contacts not tested
  3. 1990 High

    Mutagenesis showed that internal basic NLS segments are required for both nuclear import and ribosome assembly, linking the protein's localization signals to its assembly role.

    Evidence Reporter fusions, Arg→Lys substitutions, ribosome assembly and growth assays in yeast

    PMID:2104804

    Open questions at the time
    • Import receptor/pathway not identified
    • How NLS residues mechanistically couple to assembly is unclear
  4. 1989 High

    Cross-species complementation demonstrated functional conservation of the ribosomal role from mammals to yeast.

    Evidence Mouse L27'/ortholog cDNA expression rescuing growth in L29-null yeast

    PMID:2643099

    Open questions at the time
    • Competition by endogenous yeast L29 indicates incomplete equivalence
    • Does not address non-ribosomal functions
  5. 2002 High

    Genetic deletion in yeast assigned RPL29 a specific role in 60S maturation and subunit joining, situating it on the RPL10/RSA1 assembly axis.

    Evidence Gene deletion, polysome profiling (half-mers), synthetic lethality with RPL10/RSA1, and RPL10-overexpression suppression in yeast

    PMID:11997090

    Open questions at the time
    • Direct molecular role in joining versus indirect assembly effect not separated
    • Human equivalence not tested in this study
  6. 2007 High

    A knockout mouse established RPL29 as a regulator of global protein synthesis rate and organismal growth in mammals.

    Evidence Gene-targeted knockout mice with growth, proliferation, protein-synthesis, and core-RP Western blot readouts

    PMID:17195189

    Open questions at the time
    • Whether reduced synthesis reflects assembly defect or other roles not resolved
    • Tissue-specific contributions not dissected
  7. 1998 High

    Identification of the protein as the heparin-binding HIP revealed a non-ribosomal, peripheral membrane heparin/heparan sulfate-binding activity.

    Evidence Cell fractionation, salt extraction, gel-overlay heparin binding, and heparin-agarose affinity chromatography with GAG competition

    PMID:9737974

    Open questions at the time
    • How a ribosomal protein reaches the membrane is unexplained
    • Physiological partner HS structures not defined
  8. 2002 High

    Domain mapping and spectroscopy characterized multiple HS-binding domains and a heparin-induced conformational change, and live imaging tied subcellular distribution to growth/differentiation state.

    Evidence Deletion/proteolytic mapping, circular dichroism, plus GFP-fusion live imaging and fractionation in mammary epithelial cells

    PMID:11123893 PMID:11803571

    Open questions at the time
    • Trigger that drives nuclear-to-cytoplasmic shift not identified
    • Relationship between binding domains and ribosomal surface unresolved
  9. 2008 Medium

    Mechanistic assays defined how HIP/RPL29 antagonizes growth-factor signaling: displacing HS-bound VEGF/FGF2 and inhibiting heparanase.

    Evidence Tube formation, aortic explant, growth-factor displacement from perlecan, heparanase activity, and receptor phosphorylation assays

    PMID:12097308 PMID:18980226

    Open questions at the time
    • In vivo relevance of heparanase inhibition not directly shown here
    • Quantitative contribution of each mechanism to signaling output unclear
  10. 2006 Medium

    Knockdown studies placed RPL29 in a pathway opposing differentiation, acting through p21/p53 and maintaining progenitor proliferation.

    Evidence siRNA and ribozyme knockdown with differentiation marker and p21/p53 analysis in colon cancer and multipotent cell lines

    PMID:12919102 PMID:16475173

    Open questions at the time
    • Direct link between heparin-binding/ribosomal activity and p21/p53 induction not established
    • Single-lab cell-line models
  11. 2012 High

    Genetic mouse models demonstrated that RPL29 regulates tumour angiogenesis in vivo, confirming the anti-angiogenic role.

    Evidence Rpl29 heterozygous/null mice, ex vivo aortic ring sprouting, in vivo tumour vessel density, and siRNA depletion

    PMID:23118343

    Open questions at the time
    • Whether ribosomal versus extracellular HIP function drives the angiogenic phenotype is not separated
    • Direct in vivo VEGF/HS engagement not visualized
  12. 2020 High

    PAR-CLIP and translation assays revealed feedback autoregulation: eL29 binds the 3' coding region of its own mRNA, mimicking its rRNA site, to inhibit its own synthesis.

    Evidence PAR-CLIP, mRNA co-immunoprecipitation, and cell-free translation inhibition in human cells

    PMID:32798643

    Open questions at the time
    • Physiological conditions triggering autoregulation not defined
    • Quantitative impact on cellular eL29 levels not measured
  13. 2018 High

    Identification of Set7/9-dependent Lys5 methylation (reversed by Lsd1) and NMR placement at the exit tunnel added a regulatory PTM controlling localization and a structural sensing role for the nascent chain.

    Evidence Mass spectrometry, methyltransferase/demethylase assays, methyl-specific antibody and inhibitor treatment, plus NMR reconstitution into the 50S subunit

    PMID:29605910 PMID:29959229

    Open questions at the time
    • Functional consequence of K5 methylation beyond localization unknown
    • Whether nascent-chain conformational sensing recruits chaperones in vivo untested
  14. 2025 Low

    A preprint links RPL29 mRNA stability to m6A reading, proposing METTL14/IGF2BP1/3-dependent stabilization as an upstream regulator of RPL29 abundance.

    Evidence eCLIP intersection and 3'-UTR luciferase reporter assays with IGF2BP1/3 and METTL3/14 overexpression (preprint)

    PMID:bio_10.1101_2025.05.04.652102

    Open questions at the time
    • Preprint, no protein-level mechanistic validation
    • Direct m6A site on RPL29 mRNA not mapped
    • Physiological consequence on RPL29 protein levels not shown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the dual ribosomal and extracellular heparin-binding functions of RPL29 are coordinated, and which molecular activity drives its differentiation and angiogenesis phenotypes, remains unresolved.
  • No mechanism connecting ribosomal assembly role to extracellular HIP function
  • Trafficking route to the cell membrane unknown
  • Causal molecular activity behind p21/p53-mediated differentiation control not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0008289 lipid binding 2 GO:0098772 molecular function regulator activity 2 GO:0003723 RNA binding 1
Localization
GO:0005634 nucleus 2 GO:0005840 ribosome 2 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 2 R-HSA-392499 Metabolism of proteins 2
Partners
FGF2HPSEKDM1ARPL10RSA1SETD7VEGFA
Complex memberships
60S/50S large ribosomal subunit

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1990 Two specific seven-amino-acid segments from yeast ribosomal protein L29 function as nuclear localizing sequences (NLS); basic residues, especially a particular Arg residue, are critical for nuclear localization. Arg→Lys substitution in the proximal NLS greatly reduced ribosome assembly and cell growth, and substitution in both NLS caused a still greater defect, placing these sequences as necessary for both nuclear import and ribosome assembly. Reporter protein fusion, mutagenesis (Arg→Lys substitutions), yeast growth assays, ribosome assembly analysis The EMBO journal High 2104804
1980 A mutation in the structural gene for yeast ribosomal protein L29 confers cycloheximide resistance, demonstrating that L29 is the target of cycloheximide action in the large (60S) ribosomal subunit. Two-dimensional gel electrophoresis of ribosomal proteins, genetic co-segregation analysis in yeast Current genetics Medium 24189656
1982 The yeast cycloheximide resistance gene CYH2 encodes ribosomal protein L29, a component of the large (60S) subunit; the gene is present as a single copy and contains an intervening sequence. Molecular cloning, cross-hybridization, blot hybridization Nucleic acids research Medium 6285288
1981 E. coli ribosomal protein L29 is cross-linked to positions 99–107 of 23S rRNA in the 50S subunit, placing L29 in direct contact with this specific rRNA region. RNA-protein cross-linking with 2-iminothiolane followed by UV irradiation; RNA fragment identification Nucleic acids research Medium 6170935
1985 A mutant E. coli lacking ribosomal proteins S17 and L29 was used to localize L29 to the back of the 50S subunit, on the opposite side from the subunit interface, by immunoelectron microscopy. Isolation of deletion mutant, immunological localization on ribosomal surface by electron microscopy European journal of biochemistry Medium 3926498
1984 Ribosomal proteins L6 and L29 occupy closely adjacent sites in mammalian 60S subunits and can be cross-linked via intermolecular disulfide bonds; the interacting cysteine of L29 is located approximately 40 residues from its C-terminus. Disulfide cross-linking, S-cleavage after cyanylation, polyacrylamide gel electrophoresis, autoradiography European journal of biochemistry Medium 6468376
1993 In Bacillus stearothermophilus ribosomes, cross-linking with diepoxybutane identified L23 and L29 as neighboring proteins; the cross-link involved Met-1 of L23 and Lys-4 of L29. Chemical cross-linking with diepoxybutane, protein isolation, sequence analysis and mass spectrometry The Journal of biological chemistry Medium 8444837
1998 Murine HIP/RPL29 (identical to ribosomal protein L29) is enriched in the 100,000×g particulate (membrane) fraction of mammary epithelial cells and behaves as a peripheral membrane protein (eluted with 0.8 M NaCl); recombinant murine HIP/RPL29 binds heparin directly and selectively compared to other glycosaminoglycans. Cell fractionation, salt extraction, gel overlay binding assay with 125I-heparin, heparin-agarose affinity chromatography with glycosaminoglycan competition The Journal of biological chemistry High 9737974
2000 Multiple distinct domains of human and murine HIP/RPL29 contribute to heparin/heparan sulfate (Hp/HS) binding; heparin binding induces a conformational change in human HIP/RPL29 detected by circular dichroism spectroscopy. Deletion mutants, proteolytic fragments, protease-protection assays, circular dichroism spectroscopy Biochemistry High 11123893
2002 Deletion of yeast RPL29 causes accumulation of half-mer polysomes and impaired 60S-to-40S subunit joining; synthetic lethality with RPL10 (essential for subunit joining) and RSA1 (required for Rpl10 loading onto 60S), and RPL10 over-expression suppresses the half-mer phenotype, placing RPL29 as a facilitator of proper 60S subunit assembly and ribosomal subunit joining. Gene deletion, polysome profiling, in vitro translation, synthetic lethality epistasis analysis, gene over-expression suppression assay Biochimica et biophysica acta High 11997090
1989 Mouse ribosomal protein L27' (ortholog of yeast L29) can functionally substitute for yeast L29 in yeast ribosomes (supporting normal growth in L29-null cells), but is outcompeted when yeast L29 is also present, demonstrating evolutionary conservation of ribosomal function. cDNA expression in yeast, cycloheximide sensitivity assay, growth complementation assay in L29-null yeast Proceedings of the National Academy of Sciences of the United States of America High 2643099
2007 HIP/RPL29-null mice are viable but show global growth reduction (~50% smaller), delayed embryonic growth from mid-gestation, decreased proliferation and protein synthesis in embryonic fibroblasts, and reduced steady-state levels of core ribosomal proteins, establishing RPL29 as a regulator of global protein synthesis rate. Gene targeting/knockout mice, phenotypic analysis, cell proliferation assays, protein synthesis measurement, Western blotting for core RPs Developmental dynamics High 17195189
2006 Knockdown of HIP/RPL29 by siRNA in LS174T colon cancer cells induces cellular differentiation (upregulation of galectin-4 and mucin-2 markers) accompanied by upregulation of p21 and p53, placing RPL29 in a pathway that suppresses differentiation through p21/p53. siRNA knockdown, marker expression analysis (galectin-4, mucin-2), Western blot for p21/p53 Journal of cellular physiology Medium 16475173
2003 Ribozyme-mediated partial knockdown of HIP/RPL29 in C3H/10T(1/2) multipotent cells accelerates differentiation into cartilage-like cells, demonstrating that HIP/RPL29 expression maintains chondrocyte proliferation and opposes differentiation. Ribozyme-mediated knockdown, chondrogenic differentiation assay, histochemical and molecular marker analysis Differentiation; research in biological diversity Medium 12919102
2008 HIP/RPL29 inhibits VEGF- and FGF2-stimulated angiogenesis by displacing HS-bound growth factors from perlecan domain I and antagonizing heparanase (HPSE) activity (inhibiting soluble HS release); partial inhibition of VEGFR2 phosphorylation at Y951 (migration-associated site) was also observed. Endothelial tube formation assay, aortic explant assay, HBGF displacement from HS-bearing perlecan, HPSE activity assay, Western blot for receptor phosphorylation Journal of cellular biochemistry Medium 18980226
2002 Recombinant HIP/RPL29 inhibits bFGF-induced proliferation of gingival fibroblasts and specifically blocks bFGF stimulation of p44 (Erk-1) MAPK phosphorylation in a dose-dependent manner, without affecting IGF-1 responses, indicating that HIP/RPL29 modulates bFGF bioavailability via HS interactions. Cell proliferation assay, Western blot for MAPK phosphorylation, dose-response analysis with recombinant HIP/RPL29 Journal of dental research Medium 12097308
2012 RPL29 regulates tumour angiogenesis in vivo: VEGF-stimulated microvessel sprouting is significantly reduced in Rpl29-heterozygous and Rpl29-null aortic ring assays ex vivo, and tumour blood vessel density is reduced in Rpl29-mutant mice bearing Lewis lung carcinomas; siRNA depletion of Rpl29 also inhibits VEGF-induced sprouting. Rpl29 heterozygous/null mouse models, ex vivo aortic ring sprouting assay, in vivo tumour implantation, siRNA knockdown, immunohistochemistry for vessel density Disease models & mechanisms High 23118343
2018 Ribosomal protein RPL29/eL29 is a major substrate of the lysine methyltransferase Set7/9; RPL29 lysine 5 (Rpl29K5) is methylated exclusively by Set7/9 and can be demethylated by Lsd1/Kdm1a. Methylation at K5 does not affect global protein synthesis but alters RPL29 subcellular localization. Mass spectrometry substrate identification, methyltransferase assay with Set7/9 and mutants, methylation-specific antibody validation, Set7/9 inhibitor ((R)-PFI-2) treatment, subcellular localization analysis The Journal of biological chemistry High 29959229
2018 Isotopically labeled RPL29 can be reconstituted into the 50S large ribosomal subunit; RPL29 is located at the exit of the polypeptide tunnel of the 50S subunit and can undergo allosteric conformational changes induced by the nascent polypeptide chain, potentially triggering interactions with chaperones (trigger factor or SRP). Isotopic labeling, in vitro reconstitution into 50S subunit, solid-state and solution NMR Methods in molecular biology Medium 29605910
2020 Human ribosomal protein eL29 (RPL29) binds its own cognate mRNA in cells at the 3' part of the coding sequence (CDS), mimicking its rRNA binding site; overproduced eL29 inhibits translation of the eL29 mRNA CDS transcript in a cell-free system and co-immunoprecipitates with eL29 mRNA from ribosome-depleted lysate, establishing a feedback autoregulation of eL29 synthesis. 4-thiouridine-enhanced CLIP (PAR-CLIP) in HEK293T cells, next-generation sequencing, co-immunoprecipitation of mRNA, cell-free translation inhibition assay Biochimie High 32798643
2002 HIP/RPL29 intracellular distribution shifts between nuclear and cytoplasmic compartments depending on mammary epithelial cell growth/differentiation state (nuclear in proliferating/differentiating cells, cytoplasmic in mature secretory cells), as confirmed by GFP-fusion protein live imaging. Immunohistochemistry, cell fractionation, GFP-fusion protein transfection and live imaging in NMuMG cells Developmental dynamics Medium 11803571
1998 E. coli ribosomal protein L29 and acyl carrier protein (ACP) together stimulate binding of TnsD to the Tn7 attachment site (attTn7) and stimulate Tn7 transposition in vitro; mutations in L29 drastically decrease Tn7 transposition in vivo specifically for TnsABC+D reactions. In vitro transposition assay, TnsD binding assay, L29 mutant analysis in vivo The EMBO journal Medium 9755182
2025 RPL29 mRNA is a direct target of IGF2BP1/3 (m6A readers) in a METTL14-dependent manner; luciferase reporter assays showed increased mRNA stability of the RPL29 3'-UTR upon co-expression of IGF2BP1/3 and METTL3/14, indicating that m6A modification promotes IGF2BP1/3-mediated stabilization of RPL29 mRNA. eCLIP data intersection analysis, 3'-UTR luciferase reporter assay, IGF2BP1/3 and METTL3/14 overexpression bioRxiv (preprint)preprint Low bio_10.1101_2025.05.04.652102

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I. The Journal of biological chemistry 97 8253806
1990 Characterization of nuclear localizing sequences derived from yeast ribosomal protein L29. The EMBO journal 90 2104804
1981 The use of 2-iminothiolane as an RNA-protein cross-linking agent in Escherichia coli ribosomes, and the localisation on 23S RNA of sites cross-linked to proteins L4, L6, L21, L23, L27 and L29. Nucleic acids research 72 6170935
1982 Molecular cloning and analysis of yeast gene for cycloheximide resistance and ribosomal protein L29. Nucleic acids research 70 6285288
1977 Isolation of eukaryotic ribosomal proteins. Purification and characterization of 60 S ribosomal subunit proteins L3, L6, L7', L8, L10, L15, L17, L18, L19, L23', L25, L27', L28, L29, L31, L32, L34, L35, L36, L36', and L37'. The Journal of biological chemistry 68 863909
2007 Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29. Developmental dynamics : an official publication of the American Association of Anatomists 64 17195189
1989 Identified facilitator neurons L29 and L28 are excited by cutaneous stimuli used in dishabituation, sensitization, and classical conditioning of Aplysia. The Journal of neuroscience : the official journal of the Society for Neuroscience 58 2593000
1980 Altered ribosomal protein L29 in a cycloheximide-resistant strain of Saccharomyces cerevisiae. Current genetics 53 24189656
2007 The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy. British journal of pharmacology 52 17558434
2012 Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells. Molecular and cellular biochemistry 50 22868929
1985 The complete primary structure of ribosomal proteins L1, L14, L15, L23, L24 and L29 from Bacillus stearothermophilus. European journal of biochemistry 50 4018095
2006 Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. Journal of cellular physiology 40 16475173
1998 Host proteins can stimulate Tn7 transposition: a novel role for the ribosomal protein L29 and the acyl carrier protein. The EMBO journal 37 9755182
2002 RPL29 codes for a non-essential protein of the 60S ribosomal subunit in Saccharomyces cerevisiae and exhibits synthetic lethality with mutations in genes for proteins required for subunit coupling. Biochimica et biophysica acta 30 11997090
1988 Complete amino acid sequences of the ribosomal proteins L25, L29 and L31 from the archaebacterium Halobacterium marismortui. European journal of biochemistry 30 3350019
2018 Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9. The Journal of biological chemistry 29 29959229
2017 Antimicrobial effect of the 60S ribosomal protein L29 (cgRPL29), purified from the gill of pacific oyster, Crassostrea gigas. Fish & shellfish immunology 24 28663127
2009 Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 23 18661500
2012 Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice. Disease models & mechanisms 21 23118343
1989 Functional substitution of mouse ribosomal protein L27' for yeast ribosomal protein L29 in yeast ribosomes. Proceedings of the National Academy of Sciences of the United States of America 19 2643099
1987 Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Nucleic acids research 19 2434927
1975 The primary structure of the ribosomal protein L29 from Escherichia coli. Biochimica et biophysica acta 19 1092361
2003 HIP/RPL29 down-regulation accompanies terminal chondrocyte differentiation. Differentiation; research in biological diversity 18 12919102
1998 Murine HIP/L29 is a heparin-binding protein with a restricted pattern of expression in adult tissues. The Journal of biological chemistry 18 9737974
1996 A novel cDNA encoding a human homologue of ribosomal protein L29. Biochimica et biophysica acta 16 8597591
1989 Ribosomal protein gene cluster of Halobacterium halobium: nucleotide sequence of the genes coding for S3 and L29 equivalent ribosomal proteins. Canadian journal of microbiology 16 2470481
2001 Expression of heparin/heparan sulfate interacting protein/ribosomal protein l29 during the estrous cycle and early pregnancy in the mouse. Biology of reproduction 14 11259264
2008 HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses. Journal of cellular biochemistry 13 18980226
2000 Multiple domains contribute to heparin/heparan sulfate binding by human HIP/L29. Biochemistry 13 11123893
1985 A mutant from Escherichia coli which lacks ribosomal proteins S17 and L29 used to localize these two proteins on the ribosomal surface. European journal of biochemistry 13 3926498
2002 Heparan sulfate interacting protein (HIP/L29) negatively regulates growth responses to basic fibroblast growth factor in gingival fibroblasts. Journal of dental research 12 12097308
2000 Cloning, expression, and chromosome mapping of the murine Hip/Rpl29 gene. Genomics 12 10964519
1983 Direct micro-sequence analysis of peptides from Escherichia coli ribosomal proteins S11, L9 and L29 after separation by reversed phase chromatography. Hoppe-Seyler's Zeitschrift fur physiologische Chemie 10 6341200
2010 Enantioselective resolution of γ-lactam by a whole cell of Microbacterium hydrocarbonoxydans (L29-9) immobilized in polymer of PVA-alginate-boric acid. Applied biochemistry and biotechnology 9 20563863
1994 Sequence of the macronuclear DNA encoding large subunit ribosomal protein 29 (L29) in Euplotes crassus and cycloheximide sensitivity. Gene 9 7828881
1993 Cross-linked amino acids in the protein pairs L3-L19 and L23-L29 of Bacillus stearothermophilus ribosomes after treatment with diepoxybutane. The Journal of biological chemistry 9 8444837
2024 Identification of Mycobacterium abscessus using the peaks of ribosomal protein L29, L30 and hemophore-related protein by MALDI-MS proteotyping. Scientific reports 8 38755267
2010 Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth. Bone 8 20362701
2003 A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin. Journal of negative results in biomedicine 7 12659638
2002 Changes in the cytologic distribution of heparin/heparan sulfate interacting protein/ribosomal protein L29 (HIP/RPL29) during in vivo and in vitro mouse mammary epithelial cell expression and differentiation. Developmental dynamics : an official publication of the American Association of Anatomists 7 11803571
1993 The primary structure of rat ribosomal protein L29. Biochemical and biophysical research communications 7 8484767
2018 Reconstitution of Isotopically Labeled Ribosomal Protein L29 in the 50S Large Ribosomal Subunit for Solution-State and Solid-State NMR. Methods in molecular biology (Clifton, N.J.) 6 29605910
1997 Mapping of the human ribosomal large subunit protein gene RPL29 to human chromosome 3q29-qter. Genomics 6 9403071
2019 Differential expression of toll-like receptor 13 and ribosomal protein L29 in inflammatory lung and brain. Journal of biological regulators and homeostatic agents 5 31309816
2019 Knockdown RPL29 Gene Can Inhibit the Proliferation, Invasion of Squamous Cell Carcinomas. Annals of clinical and laboratory science 5 31882427
1984 Location of the sulfhydryl groups involved in disulfide interaction between the neighboring proteins L6 and L29 in mammalian ribosomes. S-cleavage of the cyanylated proteins in polyacrylamide gels after separation by dodecylsulfate gel electrophoresis. European journal of biochemistry 5 6468376
2020 The human ribosomal protein eL29 binds in vivo to the cognate mRNA by interacting with its coding sequence, as revealed from in-cell cross-linking data. Biochimie 3 32798643
1999 Analysis of the 60 S ribosomal protein L27a (L29) gene of Trypanosoma brucei. International journal for parasitology 3 10404268
2023 [Gene cloning and sequence analysis of the RPL29 gene and its effect on lipogenesis in goat intramuscular adipocytes]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2 37584125
2020 The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29. Scientific reports 2 33004906
1999 The pig aminoacylase 1 (ACY1) and ribosomal protein L29 (RPL29)/heparin/heparan sulfate interacting protein (HIP) genes are located together at 13q21-->q22, corresponding to human 3p21.1. Cytogenetics and cell genetics 1 10516434
2026 Ribosomal Protein RPL29 Promotes Hepatocellular Carcinoma Progression Through Regulation the Expression of Exosome Component 4. Biological procedures online 0 41484694
2004 Identification of 5'-upstream region of pufferfish ribosomal protein L29 gene as a strong constitutive promoter to drive GFP expression in zebrafish. Biochemical and biophysical research communications 0 14715273

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