Affinage

RPL10

Large ribosomal subunit protein uL16 · UniProt P27635

Round 2 corrected
Length
214 aa
Mass
24.6 kDa
Annotated
2026-04-28
130 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL10 (uL16) is an essential component of the 60S large ribosomal subunit whose internal loop governs intersubunit rotational dynamics, allosterically linking the peptidyl transferase center, tRNA binding sites, and subunit interface to regulate translation fidelity, catalysis, and late-stage 60S maturation through Nmd3 release (PMID:24214990, PMID:17761675). High-resolution cryo-EM structures position RPL10 at the core of the large subunit near the peptidyl transferase center, consistent with its role as a dynamic regulator rather than a passive structural element (PMID:23636399, PMID:25901680). Loss-of-function mutations (K78E, A64V, L206M) cause X-linked microcephaly, intellectual disability, and skeletal dysplasia by perturbing translational output, while the recurrent somatic R98S mutation drives pediatric T-ALL through JAK-STAT hyper-activation via altered programmed ribosomal frameshifting and IRES-dependent BCL-2 upregulation that confers sensitivity to Venetoclax (PMID:25316788, PMID:26290468, PMID:23263491, PMID:28744013, PMID:29930300). A testis-specific retrogene, RPL10L, compensates for RPL10 silencing during meiotic sex chromosome inactivation in spermatogenesis, and the two proteins are functionally interchangeable (PMID:28502657).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1992 Medium

    Establishing RPL10 as a ubiquitously expressed X-linked gene answered the basic question of genomic location and tissue distribution, placing it at Xq28 with a multi-gene family.

    Evidence Southern/Northern blot and somatic cell hybrid mapping of human QM/RPL10

    PMID:1339145

    Open questions at the time
    • Protein-level function not addressed
    • Processed pseudogene family not functionally characterized
  2. 1997 High

    Demonstrating that QM/RPL10 co-purifies with ribosomes and localizes to rough ER settled the long-debated question of whether QM is a genuine ribosomal protein rather than a standalone tumor suppressor.

    Evidence Subcellular fractionation, in situ cross-linking, ribosome co-purification from human cells

    PMID:9204867

    Open questions at the time
    • Specific position within the ribosome unknown
    • No structure available
  3. 2004 Medium

    Genetic interactions of yeast Rpl10 with the export adapter Nmd3 and the small subunit protein rpS6 revealed that Rpl10 functions beyond steady-state translation in 60S biogenesis, nuclear export, and subunit joining.

    Evidence Genetic epistasis analysis and polysome profiling in S. cerevisiae

    PMID:15556089

    Open questions at the time
    • Mechanism of Nmd3 release not defined
    • Direct physical interaction with rpS6 not confirmed
  4. 2007 High

    Systematic mutagenesis of the Rpl10 internal loop (residues 102–112) showed it is required for Nmd3 release from the 60S subunit but dispensable for stable ribosome binding, defining a specific regulatory role in late-stage 60S maturation distinct from structural incorporation.

    Evidence Site-directed mutagenesis, Nmd3 release assay, subcellular localization in yeast

    PMID:17761675

    Open questions at the time
    • Structural basis of loop-mediated Nmd3 release unknown
    • Whether the mechanism is conserved in metazoans untested
  5. 2013 High

    Chemical probing and suppressor genetics showed that the Rpl10 internal loop controls the global rotational equilibrium between non-rotated and rotated ribosome states, allosterically coupling all functional centers and linking Rpl10 to translation fidelity and Sdo1-dependent maturation.

    Evidence SHAPE/DMS rRNA probing, genetic suppressor analysis with rpL3, translation fidelity and maturation assays in yeast

    PMID:24214990

    Open questions at the time
    • Atomic-resolution view of loop conformational states lacking
    • Contribution of individual loop residues to rotational bias unresolved
  6. 2013 High

    Cryo-EM structures of the human and Drosophila 80S ribosome provided the first atomic context for RPL10 within the large subunit, confirming its position near the peptidyl transferase center and subunit interface.

    Evidence Single-particle cryo-EM at sub-nanometer to near-atomic resolution

    PMID:23636399 PMID:25901680

    Open questions at the time
    • Dynamics of RPL10 loop not captured in static structures
    • Mutant ribosome structures not available
  7. 2012 High

    Identification of recurrent somatic RPL10 R98S mutations in ~10% of pediatric T-ALL established RPL10 as the first ribosomal protein with a recurrent oncogenic point mutation, connecting ribosome function to leukemogenesis.

    Evidence Exome sequencing of T-ALL patient cohort, yeast and lymphoid cell functional validation

    PMID:23263491

    Open questions at the time
    • Downstream oncogenic mechanism not yet defined at this stage
    • Contribution to clonal fitness versus initiation unclear
  8. 2014 High

    Discovery that RPL10 K78E causes X-linked microcephaly and that zebrafish rpl10 depletion recapitulates brain size reduction and apoptosis demonstrated RPL10 is essential for brain development, defining the first Mendelian ribosomopathy linked to RPL10.

    Evidence Human XLID sequencing, zebrafish morpholino knockdown with in vivo complementation

    PMID:25316788

    Open questions at the time
    • Which neural cell types are most sensitive unknown
    • Whether apoptosis is p53-dependent not tested
  9. 2015 Medium

    The RPL10 A64V mutation, which paradoxically increases translating ribosomes, demonstrated that both gain and loss of translational output through RPL10 can cause neurodevelopmental disease, broadening the pathogenic spectrum.

    Evidence X-exome sequencing, yeast complementation, polysome profiling

    PMID:26290468

    Open questions at the time
    • Mechanism by which increased translation causes pathology unknown
    • No direct translatomic data from patient cells
  10. 2017 High

    Mechanistic dissection of RPL10 R98S in T-ALL revealed that the mutation converges on JAK-STAT hyper-activation through three independent routes: transcriptional upregulation, altered programmed ribosomal frameshifting at JAK-STAT mRNAs, and reduced JAK1 proteasomal degradation.

    Evidence Proteomics, transgenic Rpl10 R98S mouse, T-ALL xenograft, frameshifting reporters, JAK-STAT inhibitor assays

    PMID:28744013

    Open questions at the time
    • Direct structural basis for how R98S alters frameshifting efficiency not resolved
    • Whether other signaling pathways are similarly affected unclear
  11. 2017 High

    Discovery that the testis-specific retrogene RPL10L is essential for spermatogenesis by compensating for RPL10 silencing during MSCI revealed a unique gene dosage compensation mechanism and confirmed functional equivalence of the two paralogs.

    Evidence Rpl10l knockout and transgenic Rpl10 rescue in mice, ectopic expression in somatic cells

    PMID:28502657

    Open questions at the time
    • Whether RPL10L has any unique ribosomal properties not addressed
    • Mechanism of RPL10L transcriptional activation post-MSCI unknown
  12. 2018 High

    RPL10 R98S was shown to cause mitochondrial dysfunction and ROS accumulation, which cells bypass through IRES-dependent overexpression of BCL-2, creating a therapeutic vulnerability to Venetoclax in T-ALL.

    Evidence ROS and mitochondrial assays, IRES reporters, Venetoclax treatment of T-ALL xenografts

    PMID:29930300

    Open questions at the time
    • Whether Venetoclax sensitivity extends to all RPL10-mutant leukemias untested in clinical trials
    • Identity of specific IRES trans-acting factors mediating BCL-2 upregulation unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic-resolution mechanism by which the RPL10 internal loop switches between conformational states to drive intersubunit rotation, the full translatomic consequences of disease-associated RPL10 mutations in human cells, and whether RPL10-mutant ribosomes produce a qualitatively distinct proteome ('specialized ribosomes').
  • No cryo-EM structure of mutant RPL10-containing ribosomes
  • No ribosome profiling data comparing wild-type and mutant RPL10 in human cells
  • Specialized ribosome hypothesis not directly tested for RPL10

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0045182 translation regulator activity 3
Localization
GO:0005840 ribosome 3 GO:0005783 endoplasmic reticulum 2 GO:0005829 cytosol 2
Pathway
R-HSA-392499 Metabolism of proteins 4 R-HSA-1643685 Disease 3 R-HSA-162582 Signal Transduction 1
Partners
BCL2NMD3RPL10LRPL3RPS6SDO1
Complex memberships
60S large ribosomal subunit80S ribosome

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 The human QM protein (RPL10) associates with the rough endoplasmic reticulum in a peripheral, salt-sensitive manner exposed on the cytoplasmic face of the membrane, and co-purifies with the ribosome complex, demonstrating it is a bona fide ribosomal protein component of a large protein complex. Indirect immunofluorescence, subcellular fractionation, proteolytic latency assay, in situ cross-linking with diagonal SDS-PAGE, ribosome co-purification Biochemistry High 9204867
1992 The QM gene (RPL10) is located at chromosomal locus Xq28, consists of at least 7 exons, belongs to a multi-gene family with members scattered across multiple chromosomes, and is ubiquitously expressed in adult human tissues with elevated expression in liver, spleen, testis, and adrenal gland. Southern blot, Northern blot, somatic cell hybrid panel analysis, cDNA sequencing Human molecular genetics Medium 1339145
1999 QM (RPL10) is expressed in diverse embryonic tissues during mouse development, localizes to the cytoplasm consistent with ribosome association, is enriched in differentiating cells (chondrocytes, suprabasal keratinocytes) with an inverse relationship between expression level and proliferative capacity, and is absent from red blood cell precursors. Whole-mount in situ hybridization, whole-mount immunohistochemistry, immunohistochemistry on tissue sections Differentiation; research in biological diversity Medium 10234813
2002 The QM/RPL10 ortholog in Trypanosoma brucei co-localizes with the GPI:protein transamidase component GPI8, a distribution indicative of ribosome association with the rough endoplasmic reticulum, confirming conserved ribosomal function across distant eukaryotes. Epitope-tagged inducible expression, immunofluorescence microscopy FEMS microbiology letters Medium 12076801
2004 Yeast rpL10/Grc5p functionally interacts with the nuclear export factor Nmd3p to modulate the cellular polysome complement, and interacts with small subunit protein rpS6 in ribosomal subunit joining and differential protein expression, establishing rpL10 as a multifunctional regulator operating in 60S biogenesis, nuclear export, and subunit joining. Genetic interaction analysis, polysome profiling, biochemical fractionation FEMS yeast research Medium 15556089
2006 Two missense mutations in RPL10 (L206M and H213Q) found in autism-spectrum disorder families confer hypomorphism in translational regulation while keeping basic translation intact, suggesting that altered translational function—not complete loss—can contribute to neurodevelopmental disorders. RPL10 is highly expressed in mouse hippocampus. Family-based genetic analysis, functional complementation assays in yeast measuring translational regulation Molecular psychiatry Medium 16940977
2006 Heterozygous deletion of RPL10 (single-copy LSU gene) in yeast reduces the translating ribosome population and increases replicative life span by 24%, demonstrating that Rpl10 gene dosage regulates translation output and aging. Yeast replicative life span assay, polysome profiling, genetic deletion Experimental gerontology Medium 17174052
2007 Extensive mutagenesis of yeast Rpl10 revealed that a central loop (amino acids 102–112) is critical for release of the nuclear export adapter Nmd3 from the 60S subunit, while this loop is not required for stable ribosome binding, suggesting it plays a dynamic regulatory role. Rpl10 mutants unable to bind the ribosome accumulate in the nucleus, indicating an unexpected nuclear function for Rpl10. Systematic site-directed mutagenesis, genetic complementation, subcellular localization, Nmd3 release assays The Journal of biological chemistry High 17761675
2012 Exome sequencing identified recurrent somatic mutations in RPL10, particularly RPL10 R98S (Arg98Ser), in 9.8% of pediatric T-ALL cases. Yeast and lymphoid cells expressing the RPL10 R98S mutant showed a ribosome biogenesis defect, establishing RPL10 as a ribosomal protein whose mutation can drive oncogenesis. Exome sequencing, yeast functional complementation, ribosome biogenesis assay in lymphoid cells Nature genetics High 23263491
2013 An internal loop in yeast rpL10 (positioned in the core of the large subunit) is a central controller of ribosomal intersubunit rotation between non-rotated and rotated states. Mutations in this loop promote opposing shifts in the rotational equilibrium and cause defects in catalysis, translation fidelity, and Sdo1p recruitment for late-stage 60S maturation. An rpL3 suppressor mutation restoring opposing structural effects rescued an rpL10 mutant by re-establishing rotational equilibrium, demonstrating allosteric communication from rpL10 through both subunits linking all functional centers. rRNA chemical modification (SHAPE/DMS probing), mutational analysis, genetic suppressor analysis, translation fidelity assays, biochemical maturation assays Nucleic acids research High 24214990
2013 High-resolution cryo-EM structures of human and Drosophila 80S ribosomes reveal RPL10 (uL16) positioned within the large subunit, contributing to metazoan-specific ribosomal architecture and illustrating its co-evolution with rRNA. Single-particle cryo-electron microscopy, atomic model building Nature High 23636399
2014 A missense mutation in RPL10 (p.K78E) in the conserved N-terminal region near the peptidyl transferase active site causes X-linked microcephaly, growth retardation, and seizures. Suppression of rpl10 in zebrafish decreases head size, reduces bulk translation, and increases apoptosis in the brain; p.K78E is a loss-of-function variant confirmed by in vivo complementation, demonstrating RPL10 is essential for brain formation and function. X-linked intellectual disability sequencing panel, zebrafish morpholino knockdown, in vivo complementation, apoptosis assay, translation assay Genetics High 25316788
2015 A novel RPL10 missense mutation (p.A64V) in the N-terminal domain causes X-linked intellectual disability, cerebellar hypoplasia, and spondylo-epiphyseal dysplasia. Unlike other RPL10 mutations, p.A64V generates a functional ribosomal protein that increases (rather than decreases) the actively translating ribosome population in yeast, demonstrating that both gain and loss of translational output via RPL10 mutations can cause disease. X-exome resequencing, yeast complementation of conditional lethal rpl10 mutation, polysome profiling Human mutation Medium 26290468
2015 Near-atomic (3.6 Å) cryo-EM structure of the human 80S ribosome reveals RPL10 (uL16) atomic details within the large subunit, including its position relative to tRNA binding sites and the subunit interface that remodels during rotational movements. High-resolution single-particle cryo-electron microscopy, atomic model building Nature High 25901680
2017 The RPL10 R98S mutation in T-ALL causes hyper-activation of the JAK-STAT signaling pathway upon cytokine stimulation by: (1) transcriptional upregulation of JAK-STAT proteins, (2) reduction of programmed ribosomal frameshifting at frameshift signals in JAK-STAT genes leading to altered protein isoform ratios, and (3) decreased JAK1 degradation. RPL10 R98S also reduces proteasome activity. The mutual exclusivity of RPL10 R98S with JAK-STAT mutations in T-ALL patients suggests functional equivalence. Proteome screen, transgenic Rpl10 R98S mouse model, T-ALL xenograft, cytokine stimulation assays, ribosomal frameshifting reporter assays, JAK-STAT inhibitor sensitivity assays Leukemia High 28744013
2017 RPL10L (a testis-specific retrogene of RPL10) is required for spermatogenesis by compensating for RPL10, which is silenced by meiotic sex chromosome inactivation (MSCI) during spermatogenesis. Loss of Rpl10l disrupts ribosome biogenesis in late-prophase spermatocytes, blocking the prophase-to-metaphase transition. Ectopic expression of RPL10L prevents death of RPL10-deficient somatic cells, and transgenic Rpl10 expression in spermatocytes restores fertility in Rpl10l-null mice, proving functional equivalence. Knockout mouse model, transgenic rescue, ectopic expression in somatic cells, ribosome biogenesis assay, fertility assay Current biology : CB High 28502657
2018 The RPL10 R98S mutation drives accumulation of reactive oxygen species, mitochondrial dysfunction, and reduced ATP, causing a proliferation defect. Mutant cells survive high oxidative stress via specific upregulation of IRES-dependent translation of BCL-2, leading to BCL-2 protein overexpression and conferring sensitivity to the BCL-2 inhibitor Venetoclax (ABT-199), validated in T-ALL xenograft mouse models. ROS measurement, mitochondrial function assays, IRES reporter assays, Venetoclax sensitivity assays, T-ALL xenograft mouse model Leukemia High 29930300

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Molecular cell 973 22681889
2005 Nucleolar proteome dynamics. Nature 934 15635413
2005 Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Science (New York, N.Y.) 881 15790807
2004 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nature cell biology 841 14743216
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2005 The DNA sequence of the human X chromosome. Nature 816 15772651
2000 DNA cloning using in vitro site-specific recombination. Genome research 815 11076863
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2016 Genome-based phylogeny and taxonomy of the 'Enterobacteriales': proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov. International journal of systematic and evolutionary microbiology 631 27620848
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
2013 Structures of the human and Drosophila 80S ribosome. Nature 481 23636399
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2011 Defining human ERAD networks through an integrative mapping strategy. Nature cell biology 427 22119785
2010 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of proteome research 422 20020773
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2004 The molecular mechanics of eukaryotic translation. Annual review of biochemistry 396 15189156
2015 Structure of the human 80S ribosome. Nature 380 25901680
2015 Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature methods 370 26414014
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2012 Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature genetics 337 23263491
2004 Prediction of CTL epitopes using QM, SVM and ANN techniques. Vaccine 246 15297074
2011 On the Convergence of QM/MM Energies. Journal of chemical theory and computation 164 26596307
2016 How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase. The journal of physical chemistry. B 144 27704827
2001 Thioalkalimicrobium aerophilum gen. nov., sp. nov. and Thioalkalimicrobium sibericum sp. nov., and Thioalkalivibrio versutus gen. nov., sp. nov., Thioalkalivibrio nitratis sp.nov., novel and Thioalkalivibrio denitrificancs sp. nov., novel obligately alkaliphilic and obligately chemolithoautotrophic sulfur-oxidizing bacteria from soda lakes. International journal of systematic and evolutionary microbiology 140 11321103
2005 A critical evaluation of different QM/MM frontier treatments with SCC-DFTB as the QM method. The journal of physical chemistry. B 121 16852081
2004 Subdoligranulum variabile gen. nov., sp. nov. from human feces. Anaerobe 108 16701519
2006 Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Experimental gerontology 99 17174052
2017 RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Current biology : CB 96 28502657
2013 Convergence in the QM-only and QM/MM modeling of enzymatic reactions: A case study for acetylene hydratase. Journal of computational chemistry 94 23913757
2016 Exploring the Dependence of QM/MM Calculations of Enzyme Catalysis on the Size of the QM Region. The journal of physical chemistry. B 86 27552257
2014 A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans. Genetics 86 25316788
2006 Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. Molecular psychiatry 85 16940977
2016 QM/MM Calculations on Proteins. Methods in enzymology 74 27498637
2013 Effect of Geometry Optimizations on QM-Cluster and QM/MM Studies of Reaction Energies in Proteins. Journal of chemical theory and computation 73 26592409
2008 Asaccharobacter celatus gen. nov., sp. nov., isolated from rat caecum. International journal of systematic and evolutionary microbiology 71 18450720
2012 Accurate Reaction Energies in Proteins Obtained by Combining QM/MM and Large QM Calculations. Journal of chemical theory and computation 67 26589061
2012 Comparison of QM-Only and QM/MM Models for the Mechanism of Tungsten-Dependent Acetylene Hydratase. Journal of chemical theory and computation 67 26593020
2009 Theoretical studies of RNA catalysis: hybrid QM/MM methods and their comparison with MD and QM. Methods (San Diego, Calif.) 64 19398008
2017 The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. Leukemia 63 28744013
2021 Harder, better, faster, stronger: Large-scale QM and QM/MM for predictive modeling in enzymes and proteins. Current opinion in structural biology 62 34388673
2007 Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. The Journal of biological chemistry 62 17500060
2013 Eukaryotic rpL10 drives ribosomal rotation. Nucleic acids research 60 24214990
2005 Insight into enzymatic C-F bond formation from QM and QM/MM calculations. Journal of the American Chemical Society 58 16190730
1996 Emended description of Buttiauxella agrestis with recognition of six new species of Buttiauxella and two new species of Kluyvera: Buttiauxella ferragutiae sp. nov., Buttiauxella gaviniae sp. nov., Buttiauxella brennerae sp. nov., Buttiauxella izardii sp. nov., Buttiauxella noackiae sp. nov., Buttiauxella warmboldiae sp. nov., Kluyvera cochleae sp. nov., and Kluyvera georgiana sp. nov. International journal of systematic bacteriology 57 11534554
1996 Regulation of nov by WT1: a potential role for nov in nephrogenesis. Oncogene 56 8622864
2018 The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL. Leukemia 53 29930300
1983 Brevibacterium casei sp. nov. and Brevibacterium epidermidis sp. nov. Systematic and applied microbiology 52 23194737
2007 Undibacterium pigrum gen. nov., sp. nov., isolated from drinking water. International journal of systematic and evolutionary microbiology 51 17625185
2008 Effect of polarization on the opsin shift in rhodopsins. 1. A combined QM/QM/MM model for bacteriorhodopsin and pharaonis sensory rhodopsin II. The journal of physical chemistry. B 48 18698712
2023 Best Practices on QM/MM Simulations of Biological Systems. Journal of chemical information and modeling 47 37100031
2009 Extension of QM/MM docking and its applications to metalloproteins. Journal of computational chemistry 47 19373896
2007 Thalassospira xiamenensis sp. nov. and Thalassospira profundimaris sp. nov. International journal of systematic and evolutionary microbiology 46 17267971
1997 Methylosulfonomonas methylovora gen. nov., sp. nov., and Marinosulfonomonas methylotropha gen. nov., sp. nov.: novel methylotrophs able to grow on methanesulfonic acid. Archives of microbiology 46 9000341
2013 Unraveling the enigmatic mechanism of L-asparaginase II with QM/QM calculations. Journal of the American Chemical Society 45 23544711
2015 Resolving the Benzophenone DNA-Photosensitization Mechanism at QM/MM Level. The journal of physical chemistry letters 44 26262469
2009 Discovery of the rpl10 gene in diverse plant mitochondrial genomes and its probable replacement by the nuclear gene for chloroplast RPL10 in two lineages of angiosperms. DNA research : an international journal for rapid publication of reports on genes and genomes 43 19934175
2002 A role for CCN3 (NOV) in calcium signalling. Molecular pathology : MP 43 12147716
1997 The QM protein associates with ribosomes in the rough endoplasmic reticulum. Biochemistry 42 9204867
2018 QM/MM methods for free energies and photochemistry. Current opinion in structural biology 40 29414514
2015 Binding affinities by alchemical perturbation using QM/MM with a large QM system and polarizable MM model. Journal of computational chemistry 39 26280564
2012 The increasing role of QM/MM in drug discovery. Advances in protein chemistry and structural biology 39 22607760
2000 Actinoalloteichus cyanogriseus gen. nov., sp. nov. International journal of systematic and evolutionary microbiology 35 10939647
2006 Dokdonella koreensis gen. nov., sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 34 16403879
2012 Description of Fimbriimonas ginsengisoli gen. nov., sp. nov. within the Fimbriimonadia class nov., of the phylum Armatimonadetes. Antonie van Leeuwenhoek 33 22527625
2007 Mutational analysis of the ribosomal protein Rpl10 from yeast. The Journal of biological chemistry 33 17761675
2006 Classical polarization in hybrid QM/MM methods. The journal of physical chemistry. A 33 16706406
2008 Arthrobacter oryzae sp. nov. and Arthrobacter humicola sp. nov. International journal of systematic and evolutionary microbiology 32 18175682
2005 Agromyces salentinus sp. nov. and Agromyces neolithicus sp. nov. International journal of systematic and evolutionary microbiology 31 15653869
2015 A Novel Mutation in RPL10 (Ribosomal Protein L10) Causes X-Linked Intellectual Disability, Cerebellar Hypoplasia, and Spondylo-Epiphyseal Dysplasia. Human mutation 30 26290468
2005 Lactobacillus acidifarinae sp. nov. and Lactobacillus zymae sp. nov., from wheat sourdoughs. International journal of systematic and evolutionary microbiology 30 15774633
2020 Ribosomal protein QM/RPL10 positively regulates defence and protein translation mechanisms during nonhost disease resistance. Molecular plant pathology 29 32964634
2016 On-the-Fly QM/MM Docking with Attracting Cavities. Journal of chemical information and modeling 29 27983849
2003 Psychrophilic Planococcus maitriensis sp.nov. from Antarctica. Systematic and applied microbiology 29 14666977
2015 Bacillus zhangzhouensis sp. nov. and Bacillus australimaris sp. nov. International journal of systematic and evolutionary microbiology 28 26705002
2020 CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage. International journal of molecular sciences 27 33066270
2007 Parapedobacter koreensis gen. nov., sp. nov. International journal of systematic and evolutionary microbiology 27 17551054
2004 Functional interaction in establishment of ribosomal integrity between small subunit protein rpS6 and translational regulator rpL10/Grc5p. FEMS yeast research 26 15556089
2011 Comparison of QM-only and QM/MM models for the mechanism of tyrosinase. Faraday discussions 25 21322480
1988 Bilophococcus magnetotacticus gen. nov. sp. nov., a motile, magnetic coccus. Antonie van Leeuwenhoek 25 3232969
2015 Rhabdobacter roseus gen. nov., sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 24 26508300
2011 A QM/QM investigation of the hUNG2 reaction surface: the untold tale of a catalytic residue. Biochemistry 24 21473605
2002 Characterisation of the QM gene of Trypanosoma brucei. FEMS microbiology letters 24 12076801
2018 A polyphasic approach leads to seven new species of the cellulose-decomposing genus Sorangium, Sorangium ambruticinum sp. nov., Sorangium arenae sp. nov., Sorangium bulgaricum sp. nov., Sorangium dawidii sp. nov., Sorangium kenyense sp. nov., Sorangium orientale sp. nov. and Sorangium reichenbachii sp. nov. International journal of systematic and evolutionary microbiology 23 30234476
2009 Unraveling the Catalytic Pathway of Metalloenzyme Farnesyltransferase through QM/MM Computation. Journal of chemical theory and computation 23 26609858
2008 Applications and assessment of QM:QM electronic embedding using generalized asymmetric Mulliken atomic charges. The Journal of chemical physics 23 19045166
2018 QM Cluster or QM/MM in Computational Enzymology: The Test Case of LigW-Decarboxylase. Frontiers in chemistry 22 30003076
2009 Description of Leifsonia kafniensis sp. nov. and Leifsonia antarctica sp. nov. International journal of systematic and evolutionary microbiology 22 19502314
2006 Meganema perideroedes gen. nov., sp. nov., a filamentous alphaproteobacterium from activated sludge. International journal of systematic and evolutionary microbiology 22 16902022
2005 Pseudoxanthomonas koreensis sp. nov. and Pseudoxanthomonas daejeonensis sp. nov. International journal of systematic and evolutionary microbiology 22 15774663
2016 Fermentibacillus polygoni gen. nov., sp. nov., an alkaliphile that reduces indigo dye. International journal of systematic and evolutionary microbiology 21 26971318
2006 Enterococcus silesiacus sp. nov. and Enterococcus termitis sp. nov. International journal of systematic and evolutionary microbiology 21 16514030
1999 Analysis of the pattern of QM expression during mouse development. Differentiation; research in biological diversity 21 10234813
2018 Rubneribacter badeniensis gen. nov., sp. nov. and Enteroscipio rubneri gen. nov., sp. nov., new members of the Eggerthellaceae isolated from human faeces. International journal of systematic and evolutionary microbiology 20 29537365
1992 Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28. Human molecular genetics 19 1339145
2017 Description of Rhodobacter azollae sp. nov. and Rhodobacter lacus sp. nov. International journal of systematic and evolutionary microbiology 18 28829020
2015 New insights in the catalytic mechanism of tyrosine ammonia-lyase given by QM/MM and QM cluster models. Archives of biochemistry and biophysics 18 25772386
2015 Reclassification of Actinobacillus muris as Muribacter muris gen. nov., comb. nov. International journal of systematic and evolutionary microbiology 18 26296776
2015 Chujaibacter soli gen. nov., sp. nov., isolated from soil. Journal of microbiology (Seoul, Korea) 18 26310302
2007 Humicoccus flavidus gen. nov., sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology 18 17220441
2006 Goodfellowia gen. nov., a new genus of the Pseudonocardineae related to Actinoalloteichus, containing Goodfellowia coeruleoviolacea gen. nov., comb. nov. International journal of systematic and evolutionary microbiology 18 16738092
2005 Oryzihumus leptocrescens gen. nov., sp. nov. International journal of systematic and evolutionary microbiology 18 16280526
2016 Harryflintia acetispora gen. nov., sp. nov., isolated from chicken caecum. International journal of systematic and evolutionary microbiology 17 27432404
2007 Nonomuraea bangladeshensis sp. nov. and Nonomuraea coxensis sp. nov. International journal of systematic and evolutionary microbiology 17 17625184
2005 A combined QM and MM investigation into guanine quadruplexes. Journal of molecular graphics & modelling 17 16168688
2016 Incorporating QM and solvation into docking for applications to GPCR targets. Physical chemistry chemical physics : PCCP 16 27711562
2011 Reductive cleavage of the O-O bond in multicopper oxidases: a QM/MM and QM study. Faraday discussions 16 21322476
2008 Actinomadura bangladeshensis sp. nov. and Actinomadura chokoriensis sp. nov. International journal of systematic and evolutionary microbiology 16 18599711
2007 Metascardovia criceti Gen. Nov., Sp. Nov., from hamster dental plaque. Microbiology and immunology 16 17704637
2018 Effect of DNA Environment on Electronically Excited States of Methylene Blue Evaluated by a Three-Layered QM/QM/MM ONIOM Scheme. Journal of chemical theory and computation 15 29906110
2013 QM and QM/MM simulations of proteins. Methods in molecular biology (Clifton, N.J.) 15 23034747
2011 Pseudahrensia aquimaris gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 15 22021581
2010 Allobacillus halotolerans gen. nov., sp. nov. isolated from shrimp paste. International journal of systematic and evolutionary microbiology 15 20511460
2010 Allocatelliglobosispora scoriae gen. nov., sp. nov., isolated from volcanic ash. International journal of systematic and evolutionary microbiology 14 20207801
2010 Paraperlucidibaca baekdonensis gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 14 20601489
2008 Saxeibacter lacteus gen. nov., sp. nov., an actinobacterium isolated from rock. International journal of systematic and evolutionary microbiology 14 18398192
2008 Exploring the interstitial atom in the FeMo cofactor of nitrogenase: insights from QM and QM/MM calculations. The journal of physical chemistry. B 14 18707166
2006 Ancylobacter polymorphus sp. nov. and Ancylobacter vacuolatus sp. nov. International journal of systematic and evolutionary microbiology 14 16738088
2015 Pontivivens insulae gen. nov., sp. nov., isolated from seawater. International journal of systematic and evolutionary microbiology 13 26012580
2009 Solvent effects on photoreactivity of valerophenone: a combined QM and MM study. The Journal of organic chemistry 13 19950879