Affinage

RNF115

E3 ubiquitin-protein ligase RNF115 · UniProt Q9Y4L5

Length
304 aa
Mass
33.7 kDa
Annotated
2026-06-10
33 papers in source corpus 22 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RNF115 (BCA2/Rabring7) is a RING-H2 type E3 ubiquitin ligase that governs membrane-receptor trafficking, innate immune signaling, and cell proliferation by directing the fate of substrate proteins through linkage-specific ubiquitination (PMID:12972561, PMID:16473630, PMID:23418353, PMID:33139700). Its catalytic activity depends on Cys-229 of the RING domain and prefers Ubc4/Ubc5 as E2 partners, while an N-terminal BZF zinc finger binds ubiquitin and ubiquitinated proteins and is required for substrate engagement and autoubiquitination (PMID:17462600, PMID:18819927). Recruited from the cytosol to late endosomes/lysosomes by GTP-bound Rab7, RNF115 promotes endosomal sorting and lysosomal degradation of EGFR and other membrane receptors downstream of c-Cbl, with its depletion trapping cargo in late endocytic compartments (PMID:12972561, PMID:16473630, PMID:23418353). In innate immunity it acts as a bifunctional rheostat: it constitutively drives K48-linked degradation of MAVS to restrain basal antiviral tone, yet catalyzes K63-linked ubiquitination of STING/MITA to promote its Golgi localization, oligomerization, and downstream inflammation (PMID:33139700, PMID:38267694). AKT1-phosphorylated RNF115 is chaperoned by 14-3-3 to the ER/Golgi, where it places K11-linked chains on RAB1A and RAB13 to block GDI1 recruitment and impair post-ER/post-Golgi TLR trafficking (PMID:35343654). Across cancers it acts as a pro-proliferative ligase by degrading growth suppressors including p21, p53, APC, and CDK10 (PMID:24027428, PMID:32553631, PMID:33509267, PMID:38376606). RNF115 stability is itself controlled by binding partners hHR23a and 14-3-3sigma, which inhibit its autoubiquitination (PMID:22315970).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 2003 High

    Established RNF115 as a Rab7 effector, defining where in the cell it acts before any enzymatic activity was known.

    Evidence GST pull-down, Co-IP, yeast two-hybrid and live-cell imaging showing GTP-Rab7-dependent recruitment to late endosomes/lysosomes

    PMID:12972561 PMID:16473630

    Open questions at the time
    • Did not define a catalytic activity
    • Did not identify direct substrates beyond an EGF-degradation phenotype
  2. 2007 High

    Demonstrated that RNF115 is a catalytically active E3 ubiquitin ligase, identifying the essential RING residue and E2 partners.

    Evidence In vitro ubiquitination with recombinant E1/E2, RING point mutagenesis (C229S), EGFR degradation assay

    PMID:17462600

    Open questions at the time
    • Chain linkage types not determined
    • Physiological substrate repertoire unknown
  3. 2008 High

    Mapped the BZF zinc finger as a ubiquitin-binding module and defined residues controlling autoubiquitination, explaining how the ligase recognizes ubiquitinated cargo.

    Evidence Two-hybrid screening, deletion/point mutagenesis, in vivo ubiquitination, cell migration assay

    PMID:18819927

    Open questions at the time
    • Direct cellular substrates engaged via BZF not yet identified
    • Mechanism linking activity to migration unresolved
  4. 2009 High

    Connected RNF115 to antiviral restriction by showing it cooperates with tetherin to route HIV-1 virions to lysosomal degradation.

    Evidence Co-IP with tetherin, RNAi knockdown, virion release and CD63+ vesicle colocalization assays

    PMID:20019814

    Open questions at the time
    • Whether ubiquitination of a specific substrate drives restriction not defined
    • Tetherin ubiquitination status not established
  5. 2012 Medium

    Identified hHR23a and 14-3-3sigma as regulators of RNF115 stability, revealing how its autoubiquitination and abundance are controlled.

    Evidence Yeast/bacterial two-hybrid, in vitro binding, in vivo autoubiquitination assay

    PMID:22315970

    Open questions at the time
    • Kinase generating the phospho-form recognized by 14-3-3sigma not identified here
    • Physiological contexts of stabilization unclear
  6. 2013 High

    Resolved RNF115's role in receptor downregulation, placing it downstream of c-Cbl in EGFR/MET/CXCR4 sorting and MVB formation.

    Evidence Co-IP, RNAi, EGFR degradation assay, electron microscopy MVB counting, receptor sorting assays

    PMID:23418353

    Open questions at the time
    • Direct ubiquitination targets within the ESCRT pathway not defined
    • Relationship between BZF ubiquitin binding and ESCRT-II stability mechanistically open
  7. 2013 High

    Identified p21 as a degradation substrate, establishing a pro-proliferative function in ERα-positive breast cancer.

    Evidence siRNA knockdown, Co-IP, ubiquitination assay, proliferation and p21-knockdown rescue

    PMID:24027428

    Open questions at the time
    • Ubiquitin chain type on p21 not specified
    • In vivo tumor relevance not tested in this study
  8. 2017 Medium

    Extended RNF115 activity beyond ubiquitin by showing it acts as a SUMO ligase for IκBα to dampen NF-κB-driven HIV-1 transcription.

    Evidence SUMO ligase and IκBα SUMOylation assays, NF-κB reporter, HIV-1 transcription assay in CD4+ T cells

    PMID:28122985

    Open questions at the time
    • Structural basis for dual ubiquitin/SUMO ligase activity unknown
    • Generality of IκBα SUMOylation beyond HIV context untested
  9. 2020 High

    Defined a bifunctional role in innate immunity: K48-linked degradation of MAVS versus K63-linked activation of STING/MITA, with KO mice confirming both arms in vivo.

    Evidence Co-IP, K48/K63 chain-specific ubiquitination assays, Rnf115-/- mice, EMCV/HSV-1 infection

    PMID:33139700

    Open questions at the time
    • How substrate choice and chain-type are switched is unresolved
    • Upstream signals selecting MAVS vs STING targeting unclear
  10. 2020 Medium

    Linked RNF115 to autophagosome maturation through stabilization of STX17, broadening its role to membrane fusion control.

    Evidence Co-IP, RNF115 KO/depletion, autophagy flux assay, electron microscopy, tumor models

    PMID:32980859

    Open questions at the time
    • Whether stabilization is via ubiquitination is not defined
    • Direct versus indirect effect on STX17 unresolved
  11. 2020 Medium

    Identified p53 as a degradation substrate driving lung adenocarcinoma proliferation.

    Evidence Ubiquitination assay, RNF115 knockdown, cell cycle flow cytometry, xenograft

    PMID:32553631

    Open questions at the time
    • Limited mechanistic detail on direct interaction
    • Chain linkage and degron not mapped
  12. 2021 Medium

    Showed RNF115 activates Wnt/β-catenin signaling by degrading APC, expanding its oncogenic substrate set.

    Evidence Knockdown/overexpression, ubiquitination assay, Wnt/β-catenin reporter

    PMID:33509267

    Open questions at the time
    • Direct binding interface not characterized
    • In vivo relevance limited in abstract-level detail
  13. 2022 High

    Defined the mechanism by which AKT1-phosphorylated RNF115 controls TLR trafficking via K11-linked ubiquitination of RAB1A/RAB13 and disruption of GDI1 recruitment.

    Evidence Co-IP, chain-specific in vitro ubiquitination, RAB lysine mutagenesis, KO rescue, GDI1 recruitment and TLR trafficking assays

    PMID:35343654

    Open questions at the time
    • Whether the same mechanism operates outside TLR pathways untested
    • Reversal/deubiquitination of RAB K11 chains not addressed
  14. 2022 High

    Established a phagosomal role where RNF115 restrains phagosome maturation and antibacterial cytokine responses, protecting tissue during infection.

    Evidence Phagosome proteomics, RNF115 KO cells and mice, maturation and cytokine assays, S. aureus infection

    PMID:36281581

    Open questions at the time
    • Phagosomal substrates of RNF115 not identified
    • Link to its receptor-sorting function unresolved
  15. 2023 Medium

    Connected RNF115 to autophagy regulation and macrophage inflammation by showing it downregulates LC3B and modulates NF-κB/JNK in acute liver injury.

    Evidence Co-IP (RNF115-LC3B), Rnf115 KO mice, autophagy flux, cytokines, macrophage depletion

    PMID:38129372

    Open questions at the time
    • Whether LC3B is directly ubiquitinated not shown
    • Mechanistic link between LC3B downregulation and M1 activation incomplete
  16. 2024 Medium

    Added CDK10 as a degradation substrate, linking RNF115 to Raf-1 pathway activation and thyroid carcinoma progression.

    Evidence Co-IP, ubiquitination assay, CDK10 overexpression rescue, in vitro/in vivo tumor models

    PMID:38376606

    Open questions at the time
    • Chain type and degron on CDK10 not mapped
    • Direct versus indirect Raf-1 activation unclear
  17. 2024 High

    Confirmed RNF115-driven K63 ubiquitination of STING as a druggable node, with disulfiram inhibition reducing STING-dependent autoinflammation in a cell-type-specific manner.

    Evidence RNF115 KO cells/mice, disulfiram inhibition, STING oligomerization and Golgi localization assays, bone marrow chimeras, patient PBMC cytokines

    PMID:38267694

    Open questions at the time
    • Disulfiram selectivity for RNF115 over other targets not fully resolved
    • Basis for myeloid-restricted dependence unclear
  18. 2024 Medium

    Showed BCA2/RNF115 promotes breast cancer stemness by modulating MyD88-TLR4 and MyD88-OTUD4 interactions in NF-κB signaling.

    Evidence Co-IP, NF-κB and SOX9 reporter assays, overexpression/knockdown

    PMID:38725852

    Open questions at the time
    • Whether MyD88 or OTUD4 is directly ubiquitinated not established
    • Catalytic dependence of the stemness effect untested
  19. 2025 Medium

    Identified DHODH as a substrate protected from autophagic degradation via K27-linked ubiquitination, linking RNF115 to ferroptosis resistance in HCC, with translation controlled by YBX1/m5C.

    Evidence Co-IP, K27-specific ubiquitination assay, autophagy inhibition, ferroptosis assays, xenograft and DEN-induced HCC models

    PMID:40088428

    Open questions at the time
    • Structural basis for K27 chain assembly not defined
    • How K27 chains block autophagic recognition mechanistically open
  20. 2026 Medium

    Showed RNF115 uses the adaptor Tollip to recognize and K63-ubiquitinate the PEDV N protein for autophagic degradation, defining an adaptor-mediated antiviral substrate route.

    Evidence Co-IP, ubiquitination site and RING mutagenesis, K63-specific assay, Tollip RNAi, viral replication assay

    PMID:41587704

    Open questions at the time
    • Single recent study not independently confirmed
    • Discrepant RING residues (C25/C38 here vs C229 in human studies) reflect a different protein/ortholog context not reconciled

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RNF115 selects among substrates and switches ubiquitin chain linkage (K11, K27, K48, K63) and even between ubiquitin and SUMO conjugation in different compartments remains unresolved.
  • No structural model of substrate/chain-type specificity
  • Signals that toggle degradative versus activating outputs not defined
  • Interplay between its trafficking, autophagy, and immune functions not integrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 5 GO:0140096 catalytic activity, acting on a protein 5 GO:0016874 ligase activity 2 GO:0003723 RNA binding 1
Localization
GO:0005764 lysosome 2 GO:0005768 endosome 2 GO:0005794 Golgi apparatus 2 GO:0005783 endoplasmic reticulum 1 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 4 R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-9612973 Autophagy 3 R-HSA-5653656 Vesicle-mediated transport 2
Partners
EGFRLC3BMAVSRAB13RAB1ARAB7STING1TOLLIP

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Rabring7 (RNF115) specifically binds the GTP-bound form of Rab7 at its N-terminal portion, is recruited from cytosol to late endosomes/lysosomes by GTP-Rab7, and its overexpression causes perinuclear lysosomal aggregation and affects EGF degradation. GST pull-down, co-immunoprecipitation, CytoTrap yeast two-hybrid, live-cell imaging with LysoTracker Molecular biology of the cell High 12972561 16473630
2007 Rabring7 (RNF115) has E3 ubiquitin ligase activity, preferentially using Ubc4/Ubc5 as E2 partners; autoubiquitination and EGFR degradation-promoting activity require Cys-229 in the RING finger domain (C229S mutation abolishes activity). In vitro ubiquitination assay with recombinant E1/E2 proteins, RING domain point mutagenesis, EGFR degradation assay Biochemical and biophysical research communications High 17462600
2008 BCA2 (RNF115) undergoes autoubiquitination via its RING-H2 domain; the BZF zinc finger domain binds ubiquitin and ubiquitinated proteins; lysines K26/K32 in BZF are required for autoubiquitination; K232/K260 mutations near the RING domain increase autoubiquitination; BCA2 affects breast cancer cell migration. BacterioMatch two-hybrid screening, deletion/point mutagenesis, in vivo ubiquitination assay, cell migration assay Molecular cancer research High 18819927
2009 BCA2 (RNF115) is a tetherin-interacting E3 ubiquitin ligase that, in tetherin-positive cells, restricts HIV-1 particle production by facilitating internalization of virions into CD63+ intracellular vesicles and promoting their lysosomal degradation. Co-immunoprecipitation (tetherin interaction), RNAi knockdown, virion release assay, immunofluorescence for CD63+ vesicle colocalization PLoS pathogens High 20019814
2012 BCA2 (RNF115) binds hHR23a and 14-3-3sigma; hHR23a stabilizes BCA2 by inhibiting its autoubiquitination activity; phosphorylated BCA2 is stabilized by 14-3-3sigma via protein-protein interaction. Yeast two-hybrid, bacterial two-hybrid, in vitro binding with tagged proteins, in vivo autoubiquitination assay BMC cancer Medium 22315970
2012 Rabring7 (RNF115) binds MM-1 and c-Myc; monoubiquitinates MM-1 in the cytoplasm without degradation; ubiquitinates c-Myc in a Thr58-dependent manner; co-expression of Rabring7 and MM-1 leads to c-Myc degradation, requiring nuclear co-localization. Co-immunoprecipitation, in vivo ubiquitination assay, co-transfection/overexpression, knockdown of MM-1, immunofluorescence co-localization PloS one Medium 22844532
2013 Rabring7 (RNF115) associates with EGFR through its ubiquitin-binding zinc finger domain; promotes EGFR ubiquitination and lysosomal degradation; functions downstream of c-Cbl (binding is reduced in c-Cbl-deficient cells or cells expressing Cbl-70Z); depletion retains EGFR in a late endocytic compartment; also regulates MET degradation and CXCR4 sorting; depletion destabilizes ESCRT-II and reduces multivesicular body formation. Co-immunoprecipitation, RNAi depletion, EGFR degradation assay, electron microscopy (MVB counting), receptor sorting assays Journal of cell science High 23418353
2013 BCA2 (RNF115) promotes ubiquitination and proteasomal degradation of p21Waf1/Cip1; directly interacts with p21; knockdown of BCA2 increases p21 protein stability and decreases ERα-positive breast cancer cell proliferation; partial rescue of growth arrest by p21 knockdown confirms the pathway. siRNA knockdown, co-immunoprecipitation, ubiquitination assay, cell proliferation assay, rescue experiment Neoplasia High 24027428
2017 BCA2 (RNF115) acts as an E3 SUMO ligase for IκBα SUMOylation, enhancing sequestration of NF-κB components in the cytoplasm; this reduces NF-κB-dependent HIV-1 proviral transcription; BCA2 is induced by NF-κB-activating cytokines providing a negative feedback loop. SUMO ligase assay, NF-κB reporter assay, IκBα SUMOylation assay, HIV-1 transcription assay in CD4+ T cells Journal of virology Medium 28122985
2020 RNF115 constitutively interacts with MAVS and induces K48-linked ubiquitination and proteasomal degradation of MAVS in uninfected cells; after HSV-1 infection, RNF115 associates with MITA/STING and catalyzes K63-linked ubiquitination to promote MITA aggregation and antiviral signaling; Rnf115-/- mice show increased MAVS and impaired MITA aggregation. Co-immunoprecipitation, ubiquitin chain-type-specific assays (K48/K63), Rnf115 knockout mice, viral infection assays (EMCV, HSV-1), western blotting for protein levels Nature communications High 33139700
2020 RNF115 interacts with STX17 (syntaxin 17) and enhances its stability, which is required for autophagosome-lysosome fusion; RNF115 deletion impairs autophagosome maturation and causes accumulation of autophagosomes. Co-immunoprecipitation, RNF115 gene knockout/depletion, autophagy flux assay, electron microscopy, in vitro/in vivo tumor models Cell death & disease Medium 32980859
2020 RNF115 mediates ubiquitination and degradation of p53, promoting lung adenocarcinoma cell proliferation; RNF115 disruption induces G1 phase arrest and reduces tumor growth in a xenograft model. Ubiquitination assay, RNF115 knockdown/disruption, flow cytometry cell cycle analysis, xenograft tumor model Biochemical and biophysical research communications Medium 32553631
2021 RNF115 mediates ubiquitination and proteasomal degradation of APC (adenomatous polyposis coli), activating the Wnt/β-catenin signaling pathway in lung adenocarcinoma cells. RNF115 knockdown/overexpression, ubiquitination assay, Wnt/β-catenin pathway reporter assay Cancer & metabolism Medium 33509267
2022 AKT1-phosphorylated RNF115 is chaperoned by 14-3-3 proteins to localize on the ER and Golgi apparatus, where it interacts with RAB1A and RAB13, catalyzing K11-linked ubiquitination at Lys49/Lys61 of RAB1A and Lys46/Lys58 of RAB13; this modification impairs GDI1 recruitment to these RAB proteins, blocking GDP-dissociation and impairing post-ER and post-Golgi TLR trafficking. Co-immunoprecipitation, in vitro ubiquitination assay with chain-type-specific analysis, site-directed mutagenesis (RAB1A/RAB13 lysine mutants), Rnf115 KO cells with reconstitution, TLR trafficking assay Advanced science High 35343654
2022 RNF115 is enriched on phagosomes of IFN-γ-activated macrophages; loss of RNF115 protein or its ligase activity enhances phagosomal maturation and increases cytokine responses to bacterial infection; RNF115 knockout mice show less tissue damage during S. aureus infection. Quantitative proteomics of phagosomes, RNF115 knockout cells and mice, phagosomal maturation assay, cytokine measurement, S. aureus infection model The EMBO journal High 36281581
2023 RNF115 interacts with LC3B and downregulates LC3B protein levels and cellular autophagy; RNF115 deletion promotes autophagy and inhibits M1 macrophage activation via NF-κB and JNK pathways, protecting against acute liver injury. Co-immunoprecipitation (RNF115-LC3B), Rnf115 KO mice, autophagy flux assay, cytokine measurement, macrophage depletion experiment Cell death & disease Medium 38129372
2024 RNF115 ubiquitinates and promotes degradation of CDK10 in thyroid carcinoma cells, thereby activating the Raf-1 pathway and enhancing cell cycle progression; CDK10 overexpression counteracts RNF115-mediated malignant phenotypes. Co-immunoprecipitation, ubiquitination assay, CDK10 overexpression rescue, in vitro and in vivo tumor models, Raf-1 pathway analysis Cell biology and toxicology Medium 38376606
2024 RNF115 promotes K63-linked ubiquitination of STING/MITA and its Golgi localization/oligomerization; knockout or pharmacological inhibition of RNF115 by disulfiram impairs STING oligomerization and Golgi localization, reducing STING-dependent inflammation in Trex1-/- mice and STINGN153S/WT bone marrow chimeric mice in a cell-type-specific manner (myeloid cells but not endothelial cells or fibroblasts). RNF115 knockout cells and mice, disulfiram pharmacological inhibition, STING oligomerization assay, Golgi localization assay (immunofluorescence), bone marrow chimeric mice, cytokine measurement in patient PBMCs Cellular & molecular immunology High 38267694
2024 BCA2 (RNF115) enhances the interaction between MyD88 and TLR4 while inhibiting the interaction of MyD88 with deubiquitinase OTUD4 in LPS-mediated NF-κB signaling, promoting SOX9 expression and breast cancer stemness. Co-immunoprecipitation, NF-κB signaling assay, BCA2 overexpression/knockdown, SOX9 reporter assay International journal of biological sciences Medium 38725852
2025 RNF115 is an E3 ubiquitin ligase for DHODH, promoting K27-linked ubiquitination of DHODH and inhibiting its autophagic degradation to counteract ferroptosis in hepatocellular carcinoma; YBX1 promotes RNF115 mRNA translation via m5C modification of the 3'-UTR. Co-IP, ubiquitination assay (K27-specific), autophagy inhibitor experiments, RNF115 knockdown/overexpression, ferroptosis assays (lipid ROS, ferrous ion, 4-HNE), xenograft and DEN-induced HCC models Clinical and translational medicine Medium 40088428
2026 RNF115 selectively ubiquitinates the PEDV N protein via K63-linked polyubiquitin chains at K271, K276, K302, K359, and K375; requires RNF115 catalytic residues C25 and C38; the adaptor protein Tollip bridges RNF115 to the N protein in a stable complex, facilitating substrate recognition and autophagic degradation. Co-immunoprecipitation, site-directed mutagenesis (ubiquitination site mapping and RING domain mutations), K63-linkage-specific ubiquitination assay, RNAi knockdown of Tollip, viral replication assay International journal of biological macromolecules Medium 41587704

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer. Journal of medicinal chemistry 99 20222671
2020 RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Nature communications 78 33139700
2009 BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS pathogens 78 20019814
2003 Rabring7, a novel Rab7 target protein with a RING finger motif. Molecular biology of the cell 77 12972561
2008 Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration. Molecular cancer research : MCR 70 18819927
2013 The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. Journal of cell science 50 23418353
2007 Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. Biochemical and biophysical research communications 34 17462600
2022 RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 33 35343654
2021 RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination. Cancer & metabolism 29 33509267
2013 RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation. Neoplasia (New York, N.Y.) 26 24027428
2024 Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115. Cellular & molecular immunology 25 38267694
2017 BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of IκBα. Journal of virology 24 28122985
2012 Rabring7 degrades c-Myc through complex formation with MM-1. PloS one 24 22844532
2012 Effects of partner proteins on BCA2 RING ligase activity. BMC cancer 22 22315970
2025 Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma. Clinical and translational medicine 21 40088428
2022 The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection. The EMBO journal 21 36281581
2023 RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response. Cell death & disease 20 38129372
2020 Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy. Pharmacological research 20 32147403
2020 RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer. Cell death & disease 18 32980859
2010 Role of the BCA2 ubiquitin E3 ligase in hormone responsive breast cancer. The open cancer journal 18 21179390
2020 RNF115-mediated ubiquitination of p53 regulates lung adenocarcinoma proliferation. Biochemical and biophysical research communications 17 32553631
2013 Expansion and diversification of BTL ring-H2 ubiquitin ligases in angiosperms: putative Rabring7/BCA2 orthologs. PloS one 13 23951330
2012 BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 10 23242606
2024 RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma. Cell biology and toxicology 9 38376606
2021 Effects of the SUMO Ligase BCA2 on Metabolic Activity, Cell Proliferation, Cell Migration, Cell Cycle, and the Regulation of NF-κB and IRF1 in Different Breast Epithelial Cellular Contexts. Frontiers in cell and developmental biology 7 34589482
2024 E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS. International journal of biological sciences 5 38725852
2020 Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag. Frontiers in microbiology 5 32595622
2017 Autoubiquitination of feline E3 ubiquitin ligase BCA2. Gene 5 28964893
2015 Characterization and expression analysis of BCA2 gene in large yellow croaker, Larimichthys crocea. Fish & shellfish immunology 5 26208753
2025 RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression. NPJ precision oncology 1 41272272
2005 Rabring7: a target protein for rab7 small g protein. Methods in enzymology 1 16473630
2026 RNF115-Tollip coordination mediates selective autophagic degradation of N protein during PEDV infection. International journal of biological macromolecules 0 41587704
2025 Diaphorina citri E3 ubiquitin ligase RNF115 inhibits CLas bacterial proliferation by targeting to the host histone H1. Insect science 0 40079889

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