Affinage

RAB1A

Ras-related protein Rab-1A · UniProt P62820

Length
205 aa
Mass
22.7 kDa
Annotated
2026-06-10
100 papers in source corpus 49 papers cited in narrative 48 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB1A (yeast Ypt1) is an essential small GTPase that functions as a molecular switch governing ER-to-Golgi vesicular transport and, more broadly, membrane traffic across the secretory and autophagic pathways (PMID:3127057, PMID:3094963, PMID:2504726). At the cell-free level it mediates the attachment/fusion step of ER-derived secretory vesicles with the cis-Golgi and is required for both ER-to-cis-Golgi and cis-to-medial-Golgi transport, acting on the outer surface of transport vesicles (PMID:1904626, PMID:7593181). Like all Rabs, it cycles between GDP- and GTP-bound states: activation is driven by TRAPP-complex GEFs, with TRAPPIII serving as the primary GEF for both Golgi trafficking and autophagy (PMID:11102533, PMID:29109089), while specific GAPs (yptGAP, Gyp5p/Gyp8p, TBC1D20) stimulate GTP hydrolysis required for protein recycling rather than the transport event itself (PMID:2009858, PMID:9447979, PMID:12189143). Membrane attachment requires geranylgeranylation of its two C-terminal cysteines by RabGGTase, and the prenylated, GDP-bound form is extracted and chaperoned by RabGDI, whose hydrophobic pocket sequesters the lipid moiety (PMID:1903184, PMID:7991565, PMID:14576435, PMID:16395334). RAB1A nucleates effector platforms in a nucleotide-dependent manner, recruiting the Atg1/ULK1 autophagy-initiation kinase to the preautophagosomal structure via TRAPPIII and Atg9 vesicles (PMID:23716696, PMID:23129774, PMID:27334615), activating the CK1δ kinase Hrr25 to phosphorylate the COPII coat (PMID:26195667), and engaging cargo-transport and Golgi effectors including SKIP/PLEKHM2–kinesin-1 for anterograde melanosome movement, p115 for integrin β1 recycling, and GOLPH3 (PMID:20639577, PMID:25649263, PMID:32790781). Beyond membrane traffic, RAB1A transduces branched-chain amino-acid signals to mTORC1 to control β-cell insulin transcription and glucose homeostasis (PMID:33730578), and during mitosis Aurora kinase A phosphorylates RAB1A at Thr75, locking it in an active, GDI-resistant state that retains it on the ER to drive RTN/REEP-dependent ER remodeling (PMID:38177680). Its activity is further tuned by ubiquitin-dependent regulation: RNF115 catalyzes K11-linked ubiquitination at Lys49/Lys61 to impair GDI1 recruitment, while Hsc70 chaperoning and USP2a deubiquitination stabilize the protein (PMID:24801886, PMID:35343654, PMID:33074477). RAB1A is a recurrent target of intracellular pathogens, including Salmonella effectors SseF/SseG and mycobacterial PE_PGRS proteins that block its activation to suppress autophagy, and it is co-opted for the assembly and envelopment of multiple viruses (PMID:29610274, PMID:34346699, PMID:21680502, PMID:29128753).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1986 High

    Established that YPT1/RAB1A is an essential, GTP-binding protein whose nucleotide function is required in vivo, defining it as a guanine-nucleotide-dependent switch rather than a structural protein.

    Evidence Regulated depletion, site-directed mutagenesis (N121I), and GTP-binding assay in yeast

    PMID:3094963

    Open questions at the time
    • Did not place the protein in a specific trafficking step
    • Connection to microtubule/spindle phenotype mechanistically unresolved at the time
  2. 1988 High

    Linked YPT1/RAB1A directly to the secretory machinery and the Golgi, and showed lipid modification of C-terminal cysteines is required for membrane attachment and function.

    Evidence ypt1-1 loss-of-function phenotype with immunolocalization, plus [3H]palmitate labeling and cysteine mutagenesis

    PMID:3042385 PMID:3127057

    Open questions at the time
    • Lipid identity later revised to geranylgeranyl rather than palmitate
    • Exact transport step not yet defined
  3. 1990 High

    Pinpointed RAB1A function to the ER-to-Golgi vesicular transport step using reconstituted assays, distinguishing it from the ER stage and from Ca2+-dependent events.

    Evidence Cell-free ER-to-Golgi transport with antibody inhibition and recombinant rescue; complementation with wild-type cytosol

    PMID:2104983 PMID:2504726

    Open questions at the time
    • Whether RAB1A acts at tethering vs fusion not yet resolved
    • Upstream activators and downstream effectors unidentified
  4. 1991 High

    Resolved that RAB1A acts at the vesicle attachment/fusion step on the cis-Golgi, identified downstream SNARE-like machinery, and showed prenylation by the BET2 geranylgeranyltransferase is required for membrane association.

    Evidence Vesicle-intermediate accumulation assay with on-vesicle immunolocalization, SLY suppressor screen, and bet2 mutant fractionation

    PMID:1903184 PMID:1903839 PMID:1904626 PMID:1990290

    Open questions at the time
    • Molecular nature of the tethering apparatus not yet defined
    • GEF that activates RAB1A still unknown
  5. 1993 High

    Mapped the functional specificity of RAB1A versus the related Sec4 to discrete loop segments (L2 effector region and L7), explaining how closely related Rabs achieve distinct functions.

    Evidence Chimeric Ypt1/Sec4 protein swaps with in vivo complementation

    PMID:8464499

    Open questions at the time
    • Effector(s) reading these specificity determinants not identified
    • Structural basis not directly visualized
  6. 1995 High

    Defined the GTPase cycle requirements: a dedicated GEF is essential for transport, and the protein operates across two sequential Golgi steps.

    Evidence Dominant-negative D124N GEF-sequestration with XTP rescue in cell-free transport; tight ts allele with glycoprotein processing assays

    PMID:7593181 PMID:7657691

    Open questions at the time
    • Identity of the GEF not yet established
    • Spatial organization of GEF/GAP not yet mapped
  7. 1998 High

    Showed GTP hydrolysis is dispensable for the transport event itself but required for RAB1A recycling, and that the GEF and GAP are spatially segregated to acceptor and donor compartments.

    Evidence GTPase-deficient Q67L as sole copy with secretion/EM readouts; partial purification and fractionation of GEF and GAP activities

    PMID:9447979 PMID:9763446

    Open questions at the time
    • Molecular identity of fractionated GEF/GAP still unknown
    • Mechanism coupling hydrolysis to recycling not detailed
  8. 2000 High

    Identified the TRAPP complex as the physiological GEF for RAB1A, naming the long-sought activating machinery.

    Evidence GST pulldown of TRAPP subunits with GDP-release/GTP-uptake assays, size fractionation, and dominant-negative inhibition

    PMID:11102533

    Open questions at the time
    • Distinct TRAPP subcomplexes and their pathway specificities not yet resolved
    • Mammalian counterpart regulation not addressed
  9. 2006 High

    Provided the structural basis for GDI-mediated extraction and membrane targeting by visualizing how mono- and doubly geranylgeranylated RAB1A engage RabGDI.

    Evidence X-ray crystallography of prenylated Ypt1:GDI complexes with biophysical thermodynamic measurements

    PMID:14576435 PMID:16395334

    Open questions at the time
    • Membrane delivery step (GDF function) not structurally captured
    • How REP vs GDI selectivity is achieved in vivo not fully resolved
  10. 2012 High

    Extended RAB1A function beyond secretion into autophagy initiation, showing TRAPPIII/Atg9-vesicle-dependent activation recruits the Atg1/ULK1 kinase to the preautophagosomal structure.

    Evidence Yeast two-hybrid, reciprocal co-IP, fluorescence imaging, and genetic epistasis with atg17/atg9

    PMID:23129774 PMID:23716696

    Open questions at the time
    • Direct Rab1A–Atg1 contact vs indirect recruitment not fully dissected
    • Mammalian effector chain not yet defined here
  11. 2015 High

    Showed RAB1A spatially controls COPII coat phosphorylation by binding and activating the CK1δ kinase Hrr25, mechanistically coupling vesicle activation to coat dynamics in both trafficking and autophagy.

    Evidence Co-IP, kinase activity assay, and in vitro transport with hrr25 mutants

    PMID:26195667

    Open questions at the time
    • Whether mammalian RAB1A regulates CK1δ analogously not tested here
    • Direct COPII phosphosite consequences for vesicle release incomplete
  12. 2015 High

    Defined a mammalian effector cascade in which RAB1A recruits SKIP/PLEKHM2–kinesin-1 to drive microtubule-dependent anterograde melanosome transport, extending RAB1A into long-range organelle motility.

    Evidence Genome-wide Rab screen, siRNA, co-IP/GST pulldown of SKIP-kinesin-1, and live imaging

    PMID:22854043 PMID:25649263

    Open questions at the time
    • GEF activating RAB1A on melanosomes not identified
    • Relationship to canonical ER-Golgi RAB1A pool unclear
  13. 2016 High

    Established TRAPPIII as the primary in vivo RAB1A GEF for both Golgi and autophagy, revising the prior four-complex model and identifying a Trs33-dependent autophagy-specific GEF activity.

    Evidence Biochemical purification of TRAPP complexes with GEF assays; trs85/trs33 genetics with PAS imaging

    PMID:27672095 PMID:29109089

    Open questions at the time
    • TRAPP IV/Trs33 GEF activity not measured directly in vitro (Medium)
    • How a single GEF achieves pathway selectivity not fully resolved
  14. 2016 High

    Connected RAB1A to disease-relevant autophagy machinery by identifying C9orf72 as a RAB1A effector that delivers the ULK1 complex to the phagophore.

    Evidence Reciprocal co-IP of C9orf72 with RAB1A/ULK1, siRNA, and autophagy-flux assays in iNeurons

    PMID:27334615

    Open questions at the time
    • Whether C9orf72 acts as a GEF/adaptor or tether for RAB1A not resolved
    • Neurodegeneration mechanism downstream not established here
  15. 2018 High

    Revealed RAB1A as a convergent host target subverted by intracellular pathogens that block its activation to suppress autophagy.

    Evidence Co-IP of Salmonella SseF/SseG with RAB1A and TRAPPIII, GEF-disruption and ULK1/PI3P assays, plus mouse infection; mycobacterial PE_PGRS co-IP with silencing rescue

    PMID:29610274 PMID:34346699

    Open questions at the time
    • Structural basis of effector-mediated TRAPPIII displacement not solved
    • PE_PGRS interaction is single-lab co-IP/rescue (Medium)
  16. 2021 High

    Identified a signaling role distinct from membrane traffic: RAB1A transduces branched-chain amino-acid signals to mTORC1 to control insulin transcription and glucose homeostasis.

    Evidence Tamoxifen-induced whole-body Rab1A knockout mice with glucose tolerance, β-cell, and Pdx1 stability/localization analyses

    PMID:33730578

    Open questions at the time
    • Direct molecular link between RAB1A and the mTORC1 amino-acid sensing apparatus not defined
    • Whether this requires RAB1A trafficking activity unresolved
  17. 2022 High

    Defined a ubiquitin-based regulatory layer in which RNF115-catalyzed K11 ubiquitination at Lys49/61 blocks GDI1 recruitment and thereby controls RAB1A reactivation and TLR trafficking.

    Evidence Co-IP, in vitro ubiquitination, K49R/K61R mutagenesis, GDI1 recruitment and TLR trafficking assays in Rnf115 knockout cells

    PMID:35343654

    Open questions at the time
    • Counteracting deubiquitinase for K11 chains not identified here
    • Stoichiometry/dynamics of the modification in vivo unknown
  18. 2024 High

    Uncovered cell-cycle control of RAB1A: mitotic Aurora kinase A phosphorylates Thr75 to lock RAB1A active and GDI-resistant, retaining it on the ER to drive RTN/REEP-mediated ER remodeling, a conserved mechanism.

    Evidence Structural analysis, in vitro AURKA kinase assay, T75A mutagenesis, GDI interaction and ER morphology assays across C. elegans, Drosophila, and mammalian cells

    PMID:38177680

    Open questions at the time
    • Phosphatase reversing pT75 not identified
    • How ER retention is coordinated with mitotic exit unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how RAB1A's distinct activities — canonical ER-Golgi transport, autophagy initiation, organelle motility, and mTORC1 amino-acid signaling — are partitioned within a single cell, and what determines effector and GEF selection at each membrane.
  • No unified model of spatial/temporal pool segregation
  • Mechanism coupling RAB1A directly to mTORC1 sensing undefined
  • Relationship between ubiquitination, phosphorylation, and prenylation cycles not integrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 4 GO:0060089 molecular transducer activity 4 GO:0003723 RNA binding 1
Localization
GO:0005794 Golgi apparatus 4 GO:0031410 cytoplasmic vesicle 3 GO:0005783 endoplasmic reticulum 2
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9609507 Protein localization 4 R-HSA-9612973 Autophagy 4 R-HSA-162582 Signal Transduction 1
Partners
C9ORF72GDI1GOLPH3HRR25RNF115SKIP/PLEKHM2TRAPPIIIULK1

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1988 YPT1/Rab1A protein is associated with the secretory machinery; yeast ypt1-1 mutation causes accumulation of membranes and vesicles and a partial secretion defect; immunofluorescence showed the mammalian counterpart localizes to the Golgi apparatus, consistent with a role directing intracellular vesicle traffic. Genetic analysis (ypt1-1 mutation phenotype), immunofluorescence with affinity-purified antibody in yeast and mouse cells Cell High 3127057
1986 YPT1 protein is essential for cell growth; it binds GTP specifically and GTP binding is required for intracellular function; a dominant-lethal N121I substitution (site-directed mutagenesis) caused binucleated cells and abnormal spindles, demonstrating an essential function in cell cycle/microtubule organization. GAL10-regulated expression (depletion), site-directed mutagenesis, GTP-binding assay, immunofluorescence of microtubules Cell High 3094963
1989 Ypt1p is required for ER-to-Golgi protein transport in vitro; ypt1 mutations specifically abolish Golgi complex function without affecting ER activity; wild-type cytosol can restore mutant Golgi function, placing Ypt1p at an early vesicular transport step. In vitro transport assay with ypt1 mutant membranes, complementation with wild-type cytosol, genetic epistasis with other secretion genes The Journal of cell biology High 2504726
1990 Ypt1p is required for ER-to-Golgi transport in cell-free extracts; anti-Ypt1 antibodies block transport; recombinant Ypt1p rescues the inhibition; ypt1-1 extract transport is restored by wild-type cytosol. Ypt1p acts independently of Ca2+ at a distinct step. In vitro transport assay, antibody inhibition, recombinant protein rescue, Ca2+ buffering experiments Proceedings of the National Academy of Sciences of the United States of America High 2104983
1991 Ypt1p mediates the attachment or fusion step of secretory vesicles with the acceptor compartment (cis-Golgi); blocking Ypt1p activity causes accumulation of transport vesicles; Ypt1p was detected on the outer surface of these vesicles. Cell-free ER-to-Golgi transport reconstitution, antibody blocking, vesicle intermediate accumulation assay, immunolocalization on vesicles Science (New York, N.Y.) High 1904626
1991 Suppressors of YPT1 deletion (SLY1-20, SLY2, SLY12, SLY41) restore ER-to-Golgi transport in Ypt1p-deficient cells; SLY2 and SLY12 encode synaptobrevin-like proteins; SLY1p is essential and acts as a single-copy suppressor, revealing the downstream machinery of the Ypt1p-regulated transport step. Multicopy/single-copy suppressor screens, invertase/CPY processing assays, genetic epistasis, DNA sequencing Molecular and cellular biology High 1903839 1990290
1988 YPT1 protein requires at least one of its two C-terminal cysteine residues for palmitic acid (palmitoyl) modification and for membrane association; the non-palmitoylated mutant lacking both cysteines is exclusively soluble and non-functional. [3H]palmitic acid metabolic labeling, subcellular fractionation, site-directed mutagenesis, gene replacement The EMBO journal High 3042385
1991 Ypt1p membrane attachment depends on BET2 (a Rab geranylgeranyltransferase subunit homologous to DPR1/RAM1); bet2 mutants fail to attach Ypt1p and Sec4p to membranes, establishing prenylation as required for Ypt/Rab membrane association. Genetic analysis, DNA sequencing of BET2, membrane fractionation of Ypt1p/Sec4p in bet2 mutants Nature High 1903184
1994 Rab geranylgeranyltransferase (RabGGTase)/Rab escort protein catalyzes geranylgeranylation of both C-terminal adjacent cysteines of Rab1A (–XXCC motif), as demonstrated by structural analysis of in vitro prenylated protein. In vitro prenylation assay with recombinant RabGGTase, [3H]geranylgeranyl pyrophosphate incorporation, tryptic peptide HPLC, electrospray mass spectrometry Proceedings of the National Academy of Sciences of the United States of America High 7991565
1995 Ypt1p is essential for two sequential steps of the yeast secretory pathway: ER-to-cis-Golgi and cis-to-medial-Golgi transport, but not for later steps; this was established using a tight temperature-sensitive allele (ypt1-A136D) and glycoprotein processing assays. Temperature-sensitive mutant analysis (ypt1-A136D), glycoprotein processing assays (invertase, CPY, Gas1p), kinetic secretion analysis The Journal of cell biology High 7593181
1993 Specificity of Ypt1 versus Sec4 function is encoded in a 9-residue segment corresponding to loop L7 (and a 24-residue segment including the effector region, loop L2) of the GTPase; substitution of these segments of Sec4 with Ypt1 sequences converts Sec4 into a protein that can perform Ypt1 functions. Chimeric protein construction, in vivo complementation assays in yeast Nature High 8464499
2000 The TRAPP complex is a guanine nucleotide exchange factor (GEF) for Ypt1p (and Ypt31/32); GST-tagged TRAPP subunits Bet3p or Bet5p precipitate GEF activity that stimulates GDP release and GTP uptake on Ypt1p; the dominant-negative Ypt1-D124N mutant inhibits TRAPP GEF activity, suggesting in vivo relevance. GST pulldown of TRAPP subunits, GDP-release and GTP-uptake assays in vitro, gel-filtration of GEF activity (>670 kDa), dominant-negative inhibition, overexpression studies Molecular biology of the cell High 11102533
2003 Crystal structure of monoprenylated Ypt1:RabGDI complex at 1.5 Å resolution reveals the structural basis for GDI-mediated inhibition of nucleotide release; isoprenoid binding requires a conformational change opening a hydrophobic cavity in GDI domain II. Chemical synthesis of prenylated peptide, protein engineering, X-ray crystallography at 1.5 Å Science (New York, N.Y.) High 14576435
2006 Structure of doubly geranylgeranylated Ypt1:GDI complex shows one geranylgeranyl moiety deeply buried in GDI domain II hydrophobic pocket while the other is more solvent-exposed; biophysical measurements provide thermodynamic model for GDI- and REP-mediated Rab membrane interaction. Synthesis of doubly prenylated protein, X-ray crystallography, biophysical measurements (ITC, fluorescence) The EMBO journal High 16395334
1995 A Ypt1p guanine nucleotide exchange factor (GEF) activity is required for ER-to-Golgi transport; dominant-negative Ypt1p-D124N blocks transport by sequestering the GEF; XTP-dependent rescue of Ypt1-D124N confirms the nucleotide-free form sequesters GEF, demonstrating an essential role for the exchange factor in vesicular transport. In vitro ER-to-Golgi transport assay, dominant-negative and nucleotide-specificity mutant proteins, GEF activity assay (GDP release, GTP uptake) The Journal of cell biology High 7657691
1991 The effector domain of Ypt1p (residues 37–45) is required for function; mutations I41M and D44N are loss-of-function; a GTPase-activating protein (yptGAP) partially purified from porcine liver stimulates GTPase activity of Ypt1p specifically (not H-Ras) and interacts with the effector domain; I41M and D44N mutant proteins show reduced or absent GAP responsiveness. Site-directed mutagenesis and gene replacement in yeast, CPY/invertase processing assays, partial purification of yptGAP, GTPase stimulation assays The EMBO journal High 2009858
1998 GTP hydrolysis is not essential for Ypt1p-mediated vesicular transport; cells expressing GTPase-deficient Ypt1-Q67L as the sole Ypt1p have no observable growth, secretion, or morphology defects; GTP hydrolysis is required only for recycling of Ypt1p between compartments. Q67L loss-of-GTPase mutant, GAP stimulation assay, secretion assays, electron microscopy Molecular and cellular biology High 9447979
2002 Two novel Ypt1-specific GAPs, Gyp5p and Gyp8p, were identified; Gyp5p accelerates Ypt1p GTPase activity 4.2×10⁴-fold; constitutively active Ypt1(Q67L) expressing cells show growth defects and autophagy-like morphology dependent on background of GAP deletion, indicating GTP hydrolysis is needed for balanced ER-Golgi vesicle flow. GAP activity biochemical assay, subcellular fractionation, yeast genetics (GAP deletion strains), electron microscopy The Journal of biological chemistry High 12189143
2012 Ypt1/Rab1 is recruited to the preautophagosomal structure (PAS) by TRAPPIII (activated via Atg17 recruitment); activated Ypt1 then recruits the Atg1 kinase to the PAS, bringing it near its binding partner Atg17, thereby restricting Atg1 specifically to the PAS for autophagosome formation. Yeast two-hybrid, co-immunoprecipitation, fluorescence microscopy, genetic epistasis with atg17 mutants Proceedings of the National Academy of Sciences of the United States of America High 23716696
2012 Atg9 vesicles recruit the TRAPPIII complex (via direct Trs85-Atg9 interaction) and Ypt1 to the preautophagosomal structure in an Atg9-dependent manner, establishing a vesicle-tethering machinery for autophagosome formation. Atg9 vesicle purification and mass spectrometry, co-IP (Trs85-Atg9), fluorescence microscopy, deletion mutant analysis The Journal of biological chemistry High 23129774
2015 Ypt1/Rab1 binds and activates the CK1δ kinase Hrr25 to spatially regulate phosphorylation of the COPII coat, directing ER-derived vesicles to the Golgi; hrr25 mutants are defective in both ER-Golgi trafficking and macroautophagy. Co-immunoprecipitation, kinase activity assay, yeast genetic analysis (hrr25 mutants), in vitro transport assay The Journal of cell biology High 26195667
2016 TRAPPIII is the primary GEF that activates Ypt1/Rab1 in both Golgi trafficking and autophagy pathways in wild-type yeast; TRAPPII and TRAPPIII are the only two TRAPP complexes present in yeast, contrary to earlier reports of four complexes. Biochemical purification of TRAPP complexes, GEF activity assays, genetic analysis, secretion and autophagy assays The Journal of cell biology High 29109089
2016 A Trs33-containing TRAPP complex (TRAPP IV) acts as an autophagy-specific GEF for Ypt1; in the absence of Trs85, Trs33 is required for Ypt1-mediated autophagy and recruitment of core-TRAPP and Ypt1 to the PAS. Yeast genetics (trs85Δ, trs33Δ double mutants), co-IP, fluorescence microscopy of PAS markers, autophagy assays Genetics Medium 27672095
2010 Rab1a regulates cell migration by controlling integrin β1 recycling to lipid rafts and to the plasma membrane; p115 acts as a downstream effector mediating Rab1a regulation of integrin recycling and lipid raft localization. RNAi screen, siRNA knockdown, cell adhesion and spreading assays, flow cytometry (lipid raft fractionation), integrin β1 recycling assay, p115 knockdown The Journal of biological chemistry Medium 20639577
2012 Rab1A is required for microtubule-dependent anterograde melanosome transport in melanocytes; Rab1A localizes to mature melanosomes; its loss (siRNA or overexpression of dominant-negative TBC1D20 GAP) causes perinuclear melanosome aggregation and specifically suppresses long-range anterograde movements. Genome-wide constitutively active/negative Rab screen, siRNA knockdown, immunofluorescence localization, time-lapse live imaging Journal of cell science High 22854043
2015 Rab1A recruits SKIP/PLEKHM2 as a specific effector on melanosomes, and Rab1A–SKIP–kinesin-1 (Kif5b/KLC2) form a transport complex that mediates anterograde melanosome transport; Arl8 (not Rab1A) mediates anterograde lysosome transport via the same SKIP-kinesin-1 machinery. Co-immunoprecipitation, GST pulldown, siRNA knockdown, live-cell imaging, dominant-negative mutant expression Scientific reports High 25649263
2014 Rab1a regulates sorting of early endocytic vesicles for multiple cargo (EGF, transferrin, ASOR); in Rab1a knockdown cells, EGF fails to reach lysosomes and transferrin is redirected to slow Rab11 recycling rather than fast Rab4 recycling; the minus-end-directed kinesin KifC1 is identified as an effector recruited by Rab1a to early endocytic vesicles. Stable Rab1a knockdown cell line, fluorescence microscopy tracking of fluorescent cargo, co-immunoprecipitation (KifC1) American journal of physiology. Gastrointestinal and liver physiology Medium 24407591
1996 Rab1a is associated not only with ER-to-Golgi transport vesicles but also with postendosomal transcytotic vesicles in rat liver, as demonstrated by immunoisolation of vesicles using anti-Rab1a beads; these vesicles contain transcytotic markers and multiple Rab GTPases. Immunoisolation of vesicles using antibody-coated magnetic beads, Western blotting for organelle markers, [α-32P]GTP overlay The Journal of biological chemistry Medium 8939959
2016 C9orf72 interacts with Rab1a and the ULK1 autophagy initiation complex; as a Rab1a effector, C9orf72 controls initiation of autophagy by regulating Rab1a-dependent trafficking of the ULK1 complex to the phagophore. Co-immunoprecipitation (C9orf72 with Rab1a and ULK1), siRNA knockdown, autophagy flux assays (p62 accumulation, LC3 puncta), iNeuron studies The EMBO journal High 27334615
2018 Salmonella effectors SseF and SseG inhibit autophagy by directly interacting with Rab1A, disrupting its interaction with the TRAPPIII GEF complex, thereby blocking Rab1A activation, ULK1 recruitment, and phosphatidylinositol 3-phosphate biogenesis, ultimately impairing autophagosome formation. Co-immunoprecipitation (SseF/SseG with Rab1A and TRAPPIII), GEF disruption assay, ULK1 recruitment assay, PI3P measurement, siRNA rescue experiments, mouse infection model The Journal of biological chemistry High 29610274
2021 M. tuberculosis PE_PGRS20 and PE_PGRS47 inhibit autophagy initiation by directly interacting with Rab1A; silencing Rab1A rescues the survival defects of pe_pgrs20/pe_pgrs47 deletion mutants, placing Rab1A as the host target of these mycobacterial effectors. Co-immunoprecipitation (PE_PGRS proteins with Rab1A), Rab1A silencing rescue, autophagy flux assays in macrophages mSphere Medium 34346699
2017 Rab1a interacts with and regulates optineurin (OPTN)-induced autophagosome formation in neuroblastoma cells; a zinc finger domain of OPTN is required for Rab1a binding; active Rab1a (GTP-bound) is required for the interaction; Rab1a knockdown inhibits OPTN-induced LC3-EGFP translocation to autophagosomes. Yeast two-hybrid, co-immunoprecipitation, confocal microscopy colocalization, dominant-negative/constitutively-active Rab1a mutants, LC3-EGFP autophagosome translocation assay Journal of neuroscience research Medium 28843006
2014 Hsc70 interacts with Rab1A in a chaperone-dependent manner and prevents its ubiquitination and degradation under proteotoxic stress; Hsc70 knockdown decreases Rab1A levels and increases its ubiquitination; Rab1A knockdown inhibits autophagosome formation and induces cell death under stress. Anti-Hsc70 affinity purification + mass spectrometry, co-immunoprecipitation, ubiquitination assay, siRNA knockdown, autophagy assay PloS one Medium 24801886
2022 The E3 ubiquitin ligase RNF115 catalyzes K11-linked ubiquitination of RAB1A at Lys49 and Lys61; this modification impairs recruitment of GDI1 to RAB1A, preventing its reactivation cycle; RAB1A ubiquitination-resistant mutant (K49/61R) promotes ER-to-Golgi trafficking of TLRs. Co-immunoprecipitation (RNF115 with RAB1A), in vitro ubiquitination assay, site-directed mutagenesis (K49R/K61R), GDI1 recruitment assay, TLR trafficking assay in Rnf115+/+ and Rnf115−/− cells Advanced science High 35343654
2020 Ubiquitin-specific protease USP2a deubiquitinates and stabilizes RAB1A, preventing its proteasomal degradation; this stabilization is required for USP2a-mediated HCC progression. LC-MS/MS affinity proteomics, co-immunoprecipitation, ubiquitination assay, siRNA knockdown, in vitro and in vivo tumor models Cellular oncology Medium 33074477
2024 During mitosis, Aurora kinase A (AURKA) phosphorylates Rab1A at Thr75; structural analysis shows Thr75 phosphorylation locks Rab1A in a constitutively active state by preventing GDI interaction; activated Rab1A is retained on the ER and induces oligomerization of RTN and REEP ER-shaping proteins, increasing ER complexity; this mechanism is evolutionarily conserved from C. elegans and Drosophila to mammals. Structural analysis (crystal/cryo-EM implied), in vitro kinase assay (AURKA phosphorylation of Rab1A), site-directed mutagenesis (T75A), GDI interaction assay, ER morphology assay, genetic modification in C. elegans/Drosophila/mammalian cells Nature structural & molecular biology High 38177680
2011 In Dictyostelium, Rab1A binds the LRRK2-related Roco kinase Roco2 in vivo; active GTP-bound Rab1A regulates Roco2 kinase activity; Roco2 in turn controls F-actin polymerization and pseudopod extension by acting upstream of filamin (abp120), establishing a Rab1A-Roco2-filamin pathway regulating actin cytoskeleton and cell motility. Co-immunoprecipitation (Roco2 with Rab1A and filamin), kinase activity assay, constitutively active/dominant-negative Rab1A mutants, chemotaxis assays, F-actin measurement Molecular biology of the cell Medium 21551065
2011 Rab1A (and Rab43) is required for herpes simplex virus 1 secondary envelopment; depletion of Rab1a/b via their specific GAP TBC1D20 prevents viral glycoproteins from trafficking from the ER to the viral assembly compartment, resulting in accumulation of unenveloped particles. Overexpression of 37 Rab-GAPs (functional screen), siRNA knockdown, infectious titer assay, immunofluorescence microscopy of viral glycoproteins, electron microscopy Journal of virology Medium 21680502
2014 RAB1A is required for Vaccinia virus production of intracellular enveloped virions (IEVs) but not intracellular mature virions (IMVs); RAB1A facilitates the wrapping step consistent with its role in ER-to-Golgi transport. siRNA knockdown, infectious titer assay, immunofluorescence, electron microscopy Virology Medium 25462347
2017 Rab1A is required for classical swine fever virus (CSFV) particle assembly; Rab1A binds CSFV NS5A protein; Rab1A depletion reduces intracellular and extracellular viral titers without affecting viral genome replication or E2 protein expression, specifically implicating particle assembly. siRNA knockdown, viral titer assay, qRT-PCR (genome copies), co-immunoprecipitation (Rab1A–NS5A), confocal microscopy, neutralizing antibody blocking assay Virology Medium 29128753
2011 Rab1A overexpression prevents Golgi fragmentation caused by alpha-synuclein in dopaminergic neurons; the non-prenylable Rab1A-ΔCC mutant fails to rescue Golgi morphology, linking the protective effect to Rab1A's ER-to-Golgi trafficking activity. AAV-mediated co-expression in rat substantia nigra, Golgi morphology assay, non-prenylable mutant analysis, motor behavior assay Journal of Parkinson's disease Medium 23939344
2012 Ypt1 protein specifically associates in vivo with unspliced HAC1 RNA and promotes HAC1 RNA decay; this association is disrupted during ER stress induction of the UPR; Ypt1 depletion reduces HAC1 RNA decay rate, elevating HAC1 levels and delaying UPR attenuation. Protein microarray screening for HAC1 RNA binding, RNA co-immunoprecipitation, HAC1 RNA decay assays, genetic analysis (ire1Δ, ada5Δ) PLoS genetics Medium 22844259
2020 Human GOLPH3 is a direct effector of RAB1A and RAB1B; interaction is nucleotide-dependent, favored by GTP-locked (active) variants; expression of GTP-locked RAB1A reduces GOLPH3 localization at the Golgi, suggesting Rab1A-GTP releases GOLPH3 from the Golgi. Co-immunoprecipitation (GOLPH3 with RAB1A/B wild-type and GTP-locked mutants), fluorescence microscopy of GOLPH3 distribution PloS one Medium 32790781
2021 Rab1A mediates amino acid (particularly branched-chain amino acid)-dependent mTORC1 signaling in vivo; whole-body Rab1A knockout mice are hyperglycemic and glucose intolerant due to impaired insulin transcription and β-cell proliferation/maintenance; mechanistically, Rab1A mediates BCAA-mTORC1 signaling to regulate stability and localization of the insulin transcription factor Pdx1. Tamoxifen-induced whole-body Rab1A knockout mouse, glucose tolerance test, insulin assay, β-cell analysis, Pdx1 localization and stability assay Cell reports High 33730578
2021 NAB2 (an N-arylbenzimidazole small molecule) binds Rab1a selectively in its GDP-bound form; NAB2 binding phenocopies Rab1a overexpression in alleviating α-synuclein toxicity; Rab1a was identified as a target of NAB2 by Thermal Proteome Profiling and SPROX chemoproteomic analyses. Thermal Proteome Profiling (TPP), SPROX chemoproteomic analysis, cellular phenotypic assay (α-synuclein toxicity rescue), GDP/GTP-state selectivity binding assay RSC chemical biology Medium 35128413
2022 Rab1a interacts with ULK1 and promotes ULK1 phosphorylation dependent on its GTP-binding activity; this Rab1a-ULK1 interaction initiates autophagy that promotes PRRSV replication. Co-immunoprecipitation (Rab1a with ULK1), ULK1 phosphorylation assay, GTP-binding mutant analysis, ATG7 knockdown rescue, viral titer assay Virus research Medium 36306941
2005 Yeast Yip3p (a GDI displacement factor ortholog) forms a distinct complex with Ypt1p that is separable from its complex with reticulon Rtn1p; Yip3p is predominantly Golgi-localized; however, loss of Yip3p or Rtn1p does not perturb intracellular Rab localization, indicating Yip3p-Ypt1p interaction is not critical for Rab membrane targeting. Co-purification from detergent extracts, Western blotting, fluorescence microscopy in yip3Δ and rtn1Δ mutants Eukaryotic cell Medium 16002643
1998 A Ypt1p-specific GEF activity localizes to the acceptor (Golgi) fraction rather than the donor (ER) fraction; a Ypt1p-specific GAP activity colocalizes with ER markers; the GEF is specific for Ypt1p and not other Ypt proteins; the GAP has higher affinity for GTP-bound Ypt1p. Partial purification of GEF and GAP activities from yeast fractions, GDP-release and GTP-uptake assays, GTPase stimulation assay, subcellular fractionation Molecular biology of the cell Medium 9763446

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1988 The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell 636 3127057
1989 The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. The Journal of biological chemistry 362 2501306
2016 The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. The EMBO journal 327 27334615
1991 Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Molecular and cellular biology 291 1990290
1986 The ras-related YPT1 gene product in yeast: a GTP-binding protein that might be involved in microtubule organization. Cell 235 3094963
1988 Study of a temperature-sensitive mutant of the ras-related YPT1 gene product in yeast suggests a role in the regulation of intracellular calcium. Cell 220 3286011
1989 The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants. The Journal of cell biology 207 2504726
1990 Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line. Molecular and cellular biology 196 2123294
2000 The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32. Molecular biology of the cell 177 11102533
1990 GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction. Proceedings of the National Academy of Sciences of the United States of America 173 2104983
2003 Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (New York, N.Y.) 166 14576435
1991 The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport. Molecular and cellular biology 166 1903839
1991 Mediation of the attachment or fusion step in vesicular transport by the GTP-binding Ypt1 protein. Science (New York, N.Y.) 140 1904626
1994 Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proceedings of the National Academy of Sciences of the United States of America 135 7991565
1995 The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway. The Journal of cell biology 131 7593181
1987 The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. The EMBO journal 125 3127202
2013 MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A. Oncogene 123 23770851
1988 A carboxyl-terminal cysteine residue is required for palmitic acid binding and biological activity of the ras-related yeast YPT1 protein. The EMBO journal 122 3042385
1989 The ras-related mouse ypt1 protein can functionally replace the YPT1 gene product in yeast. The EMBO journal 121 2670553
1991 Dependence of Ypt1 and Sec4 membrane attachment on Bet2. Nature 114 1903184
2005 Aberrant expression of RAB1A in human tongue cancer. British journal of cancer 112 15870709
2013 Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Proceedings of the National Academy of Sciences of the United States of America 110 23716696
1993 Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4. Nature 103 8464499
2012 Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site. The Journal of biological chemistry 95 23129774
2010 Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration. The Journal of biological chemistry 94 20639577
1987 The ras-like yeast YPT1 gene is itself essential for growth, sporulation, and starvation response. Molecular and cellular biology 94 3302675
2006 Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. The EMBO journal 86 16395334
1991 Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity. The EMBO journal 73 2009858
2002 Significance of GTP hydrolysis in Ypt1p-regulated endoplasmic reticulum to Golgi transport revealed by the analysis of two novel Ypt1-GAPs. The Journal of biological chemistry 68 12189143
2011 Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment. Journal of virology 66 21680502
2017 The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway. The Journal of cell biology 65 29109089
1995 Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport. The Journal of cell biology 63 7657691
2015 Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy. The Journal of cell biology 62 26195667
2015 miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A. Oncotarget 61 26023735
2015 Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A. Oncotarget 61 26308575
2018 The Salmonella effectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication. The Journal of biological chemistry 56 29610274
2011 Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. Journal of Parkinson's disease 55 23939344
2021 Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A. mSphere 54 34346699
2018 LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma. Bioscience reports 47 29301870
1996 Tomato Rab1A homologs as molecular tools for studying Rab geranylgeranyl transferase in plant cells. Plant physiology 46 8934628
2012 Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes. Journal of cell science 44 22854043
2015 Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Scientific reports 42 25649263
2015 miR-184 and miR-150 promote renal glomerular mesangial cell aging by targeting Rab1a and Rab31. Experimental cell research 41 26165933
1998 GTP hydrolysis is not important for Ypt1 GTPase function in vesicular transport. Molecular and cellular biology 40 9447979
1996 Rab1a and multiple other Rab proteins are associated with the transcytotic pathway in rat liver. The Journal of biological chemistry 40 8939959
2014 The Rab GTPase YPT-1 associates with Golgi cisternae and Spitzenkörper microvesicles in Neurospora crassa. Molecular microbiology 39 25425138
2017 Evaluation of Different PCR-Based Assays and LAMP Method for Rapid Detection of Phytophthora infestans by Targeting the Ypt1 Gene. Frontiers in microbiology 37 29051751
2020 Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis. Journal of biochemistry 36 31598673
2016 miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33. Molecular oncology 35 27693040
2014 Rab1a regulates sorting of early endocytic vesicles. American journal of physiology. Gastrointestinal and liver physiology 35 24407591
2014 Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions. PloS one 35 24801886
2022 RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 33 35343654
2017 Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells. Oncology reports 32 28184936
2016 Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage. Aging 32 27902464
2005 Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p. Eukaryotic cell 32 16002643
2021 Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Cell reports 30 33730578
2015 MicroRNA-101 inhibits rat cardiac hypertrophy by targeting Rab1a. Journal of cardiovascular pharmacology 30 25850725
2019 Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer. Oncology reports 28 30896866
1998 Identification of regulators for Ypt1 GTPase nucleotide cycling. Molecular biology of the cell 28 9763446
1994 Functional complementation of a yeast vesicular transport mutation ypt1-1 by a Brassica napus cDNA clone encoding a small GTP-binding protein. Plant molecular biology 27 7858213
2020 Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A. Cellular oncology (Dordrecht, Netherlands) 26 33074477
2016 Trs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF. Genetics 26 27672095
2019 miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A. Oncology reports 25 31485677
2017 MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 25 28443461
1989 Biochemical properties of the YPT-related rab1B protein. Comparison with rab1A. FEBS letters 25 2509243
2022 Exosome-transmitted circ_002136 promotes hepatocellular carcinoma progression by miR-19a-3p/RAB1A pathway. BMC cancer 24 36476239
2019 MiR-655-3p inhibited proliferation and migration of ovarian cancer cells by targeting RAB1A. European review for medical and pharmacological sciences 24 31114987
2017 Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells. Journal of neuroscience research 24 28843006
2014 RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions. Virology 24 25462347
2012 The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. PLoS genetics 24 22844259
2019 Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis. The Journal of pharmacology and experimental therapeutics 23 31843814
2017 Rab1A is required for assembly of classical swine fever virus particle. Virology 23 29128753
2004 Characterization of secretory genes ypt1/yptA and nsf1/nsfA from two filamentous fungi: induction of secretory pathway genes of Trichoderma reesei under secretion stress conditions. Applied and environmental microbiology 23 14711675
2001 Overexpression of a dominant-negative allele of YPT1 inhibits growth and aspartyl protease secretion in Candida albicans. Microbiology (Reading, England) 22 11429473
2014 Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues. International journal of oncology 21 25339198
2009 The RAB family GTPase Rab1A from Plasmodium falciparum defines a unique paralog shared by chromalveolates and rhizaria. The Journal of eukaryotic microbiology 21 19602080
1998 Genetic interaction between YPT6 and YPT1 in Saccharomyces cerevisiae. Yeast (Chichester, England) 21 9717237
1991 Identification and partial purification of GTPase-activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins. FEBS letters 21 1936282
2020 MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway. Neurochemical research 20 32124161
2018 Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a. Cancer biology & therapy 20 29672195
2008 Synthetic lethality between eIF5A and Ypt1 reveals a connection between translation and the secretory pathway in yeast. Molecular genetics and genomics : MGG 20 18568365
2019 Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy. Medical science monitor : international medical journal of experimental and clinical research 19 30865617
2020 Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma. Aging 18 33068388
1996 Isolation of an additional soybean cDNA encoding Ypt/Rab-related small GTP-binding protein and its functional comparison to Sypt using a yeast ypt1-1 mutant. Plant molecular biology 18 8806409
2021 Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer. Cancer letters 17 34627950
2011 The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Molecular biology of the cell 17 21551065
2021 Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity. RSC chemical biology 15 35128413
2022 Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543. Anti-cancer drugs 14 36255068
2020 Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway. Archives of biochemistry and biophysics 14 32240637
2023 Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC. Translational oncology 13 37216755
2020 CircRNA circUGGT2 Contributes to Hepatocellular Carcinoma Development via Regulation of the miR-526b-5p/RAB1A Axis. Cancer management and research 13 33116877
1994 Effect of tumour progression on the androgenic regulation of the androgen receptor, TRPM-2 and YPT1 genes in the Shionogi carcinoma. The Journal of steroid biochemistry and molecular biology 13 8049130
2020 Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B. PloS one 12 32790781
1992 Distinct and specific GAP activities in rat pancreas act on the yeast GTP-binding proteins Ypt1 and Sec4. FEBS letters 12 1511744
2015 Ypt1 and COPII vesicles act in autophagosome biogenesis and the early secretory pathway. Biochemical Society transactions 11 25619251
2024 Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis. Nature structural & molecular biology 10 38177680
2022 Autophagy induced by Rab1a-ULK1 interaction promotes porcine reproductive and respiratory syndrome virus replication. Virus research 10 36306941
2022 Circ_0061140 Contributes to the Malignant Progression in Ovarian Cancer Cells by Mediating the RAB1A Level Through Sponging miR-361-5p. Biochemical genetics 9 35181843
2019 Gyp1 has a dual function as Ypt1 GAP and interaction partner of Atg8 in selective autophagy. Autophagy 9 30686108
2021 Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer. Scientific reports 8 34376787

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