Affinage

RASSF1

Ras association domain-containing protein 1 · UniProt Q9NS23

Length
344 aa
Mass
39.2 kDa
Annotated
2026-04-28
58 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RASSF1 is a Ras effector and scaffold protein that integrates Ras-GTP signaling, Hippo pathway regulation, and microtubule dynamics to exert tumor-suppressive functions. It binds Ras in a GTP-dependent manner through its RA domain and mediates caspase-dependent apoptosis downstream of activated Ras, ATF4-driven ER stress, and BMP-2 signaling (PMID:10998413, PMID:36723232, PMID:27230238). Through its SARAH domain, RASSF1A interacts with MST1/2 kinases, restraining their autoactivation in quiescent cells while facilitating context-dependent Hippo pathway activation that promotes YAP phosphorylation and suppresses proliferation (PMID:15109305, PMID:16757333, PMID:38493147). RASSF1A additionally stabilizes microtubules, cooperates with Daxx in a mitotic checkpoint controlling cyclin B turnover, and restricts SRC kinase activity at cell–cell junctions; loss of RASSF1A by promoter methylation shifts signaling toward the RASSF1C isoform, which activates SRC/YES and derepresses YAP1 to promote invasion (PMID:16135822, PMID:21643015, PMID:26549256).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2000 High

    Establishing RASSF1 as a direct Ras effector answered the question of whether RAS-family GTPases signal through RASSF proteins and showed that RASSF1-mediated apoptosis is Ras-dependent and caspase-dependent.

    Evidence In vitro pulldown, co-IP, and epistasis with dominant-active/dominant-negative Ras in transfected cells

    PMID:10998413

    Open questions at the time
    • Structural basis of GTP-dependent Ras–RASSF1 interaction not determined
    • Endogenous Ras–RASSF1 complex not demonstrated
    • Downstream caspase cascade not mapped
  2. 2002 Medium

    Identification of C19ORF5 as a RASSF1 interactor and visualization of RASSF1 on microtubules and mitochondria revealed that RASSF1 operates at the cytoskeleton and mitochondria, not solely in cytosolic Ras signaling.

    Evidence Yeast two-hybrid screen and GFP co-localization with β-tubulin and mitochondria

    PMID:12762840

    Open questions at the time
    • Functional significance of mitochondrial localization unclear
    • Direct binding to tubulin not demonstrated
  3. 2004 High

    Demonstration that RASSF1A inhibits MST1 autoactivation in vitro yet permits activation when recruited to membranes established the dual-function scaffold model: RASSF1A restrains MST1/2 in the cytoplasm but enables context-dependent activation at membranes.

    Evidence Endogenous co-IP from KB cells, reconstituted in vitro kinase assays with purified proteins, CAAX-targeted constructs

    PMID:15109305

    Open questions at the time
    • In vivo physiological membrane-targeting signal unknown
    • Stoichiometry of RASSF1A–MST1 complex not quantified
  4. 2004 High

    Discovery of the RASSF1–PMCA4b interaction at the plasma membrane, which inhibits EGF-driven ERK signaling, revealed a non-Ras mechanism by which RASSF1 limits MAPK activation.

    Evidence Yeast two-hybrid, co-IP, GST pulldown, and ERK activity rescue with competing peptide

    PMID:15145946

    Open questions at the time
    • Whether PMCA4b–RASSF1 interaction is isoform-specific (RASSF1A vs 1C) not resolved
    • In vivo relevance in animal models not tested
  5. 2005 High

    Rassf1A knockout mice showed increased tumorigenesis and MEF hypersensitivity to microtubule-destabilizing agents, providing genetic proof that RASSF1A functions as a tumor suppressor through microtubule stabilization in vivo.

    Evidence Targeted gene deletion in mouse, primary fibroblast drug sensitivity assays, tumor monitoring

    PMID:15753381 PMID:16135822

    Open questions at the time
    • Whether microtubule stabilization or Hippo regulation is the primary tumor-suppressive mechanism not distinguished
    • Tissue-specific contributions not dissected
  6. 2011 Medium

    Identification of the RASSF1–Daxx interaction and its role in a mitotic checkpoint that regulates cyclin B stability linked RASSF1 to mitotic fidelity beyond simple microtubule stabilization.

    Evidence Co-IP, RNAi, time-lapse microscopy, cyclin B stability assays, in vitro APC/C assay

    PMID:21643015

    Open questions at the time
    • Mechanism by which RASSF1–Daxx promotes cyclin B degradation without altering APC/C activity in vitro not explained
    • Single-lab finding; independent replication absent
  7. 2015 High

    Affinity proteomics and proximity ligation revealed that RASSF1A restricts SRC activity while RASSF1C activates SRC/YES at cell junctions, explaining how promoter methylation-driven isoform switching derepresses YAP1 and promotes invasion.

    Evidence Affinity proteomics, PLA, live-cell imaging, phosphorylation assays in epithelial cells

    PMID:26549256

    Open questions at the time
    • Direct binding interface between RASSF1C and SRC/YES not mapped
    • Whether RASSF1C activates YAP independently of MST1/2 not resolved
  8. 2016 Medium

    Placing RASSF1 upstream of MST1–YAP in BMP-2 signaling in esophageal cancer cells extended the RASSF1–Hippo axis to growth factor contexts beyond canonical Ras.

    Evidence Co-IP of RASSF1–MST1 under BMP-2 treatment, siRNA knockdown, xenograft

    PMID:27230238

    Open questions at the time
    • Single co-IP without reciprocal validation under BMP-2
    • Whether BMP-2 triggers RASSF1A membrane recruitment not tested
  9. 2023 Medium

    ChIP and reporter assays showing ATF4 directly activates RASSF1 transcription, and that RASSF1 loss abrogates tunicamycin-induced apoptosis, established RASSF1 as a transcriptional target of the integrated stress response mediating ER stress-induced cell death.

    Evidence ChIP, luciferase reporter, RASSF1 knockdown, tunicamycin-induced apoptosis

    PMID:36723232

    Open questions at the time
    • Whether RASSF1A or RASSF1C is the isoform induced by ATF4 not specified
    • Downstream effector pathway (Hippo vs other) linking RASSF1 to BBC3 not resolved
  10. 2024 Medium

    Demonstration that Rassf1 activates the full Hippo phosphorylation cascade (p-MST1/2 → p-LATS1 → p-YAP) during bacterial infection-induced apoptosis in pulmonary epithelial cells extended RASSF1–Hippo signaling to innate immune and infection contexts.

    Evidence RNA-seq, siRNA knockdown, phospho-Western blots, mouse/rabbit infection models, XMU-MP-1 rescue

    PMID:38493147

    Open questions at the time
    • Direct physical interaction between RASSF1 and MST1/2 not confirmed in pulmonary epithelial cells
    • Whether RASSF1 acts cell-autonomously or through paracrine signaling not distinguished

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis for RASSF1A's dual role as MST1/2 inhibitor in the cytoplasm versus activator at membranes; the relative contributions of microtubule stabilization, Hippo activation, and SRC restriction to tumor suppression; and the mechanism by which RASSF1C opposes RASSF1A function at the molecular level.
  • No high-resolution structure of RASSF1A–MST1 SARAH domain complex
  • Genetic separation of microtubule-stabilizing vs Hippo-activating functions not achieved in vivo
  • Biochemical basis by which RASSF1C activates SRC/YES while RASSF1A inhibits it not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 5 GO:0098772 molecular function regulator activity 4
Localization
GO:0005856 cytoskeleton 3 GO:0005739 mitochondrion 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1640170 Cell Cycle 2
Partners
ATP2B4C19ORF5DAXXMST1MST2SRCYES1

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 RASSF1 binds Ras in a GTP-dependent manner both in vivo and directly in vitro, and functions as a Ras effector that mediates apoptosis; activated Ras enhances RASSF1-induced cell death while dominant negative Ras inhibits it, and the cell death is caspase-dependent. In vitro pulldown, co-immunoprecipitation, transient transfection with dominant-active/dominant-negative Ras, caspase inhibitor rescue The Journal of biological chemistry High 10998413
2004 Endogenous MST1 co-immunoprecipitates with RASSF1A and NORE1A from KB cells; co-expression of RASSF1A suppresses MST1 Thr183 autophosphorylation and abolishes Mg-ATP-mediated MST1 autoactivation in vitro, acting as an inhibitor of MST1/2 kinase activation. However, membrane-targeted NORE1A or Ras(G12V)-recruited MST1 shows increased Thr183 phosphorylation, indicating context-dependent activation. Co-immunoprecipitation of endogenous proteins, in vitro kinase autoactivation assay, in vitro addition of purified recombinant proteins, co-transfection with CAAX-tagged or myristoylated constructs The Biochemical journal High 15109305
2004 RASSF1 (region 74-123 of RASSF1C / 144-193 of RASSF1A) physically interacts with the second intracellular loop (residues 652-748) of plasma membrane Ca2+-ATPase PMCA4b; this interaction was identified by yeast two-hybrid, confirmed by co-immunoprecipitation, immunofluorescence co-localization, and GST pulldown. Functional consequence: co-expression of PMCA4b and RASSF1 inhibits EGF-dependent ERK pathway activation, and this inhibition is abolished by a competing peptide that blocks PMCA/RASSF1 association. Yeast two-hybrid screen, co-immunoprecipitation, GST pulldown, immunofluorescence co-localization, ERK pathway activity assay with competing peptide The Journal of biological chemistry High 15145946
2005 Both RASSF1A and RASSF1C localize to mitochondria and microtubules and exhibit paclitaxel-like microtubule hyperstabilization and disruption of mitosis. When co-expressed with C19ORF5 (a MAP1B homologue that accumulates on hyperstabilized microtubules and causes cell death), the unique N-terminal sequence of RASSF1C prevents microtubule hyperstabilization, conferring specificity on RASSF1A for this function. Subcellular localization by immunofluorescence/GFP tagging, co-expression and microtubule stabilization assays, interaction with C19ORF5 Cancer research Medium 15753381
2002 C19ORF5 interacts with RASSF1 (identified by yeast two-hybrid interaction cloning); GFP-tagged RASSF1 co-localizes with mitochondria and beta-tubulin in the cytosol during interphase and reorganizes around separating chromosomes during mitosis. Yeast two-hybrid interaction cloning, GFP-tagging and immunofluorescence co-localization In vitro cellular & developmental biology. Animal Medium 12762840
2005 RASSF1A null mouse embryonic fibroblasts display increased sensitivity to microtubule-depolymerizing agents, establishing a role for RASSF1A in microtubule stability in vivo. Rassf1A null mice show increased spontaneous and irradiation-induced tumorigenesis. Targeted gene deletion in mouse, microtubule depolymerization sensitivity assay in primary fibroblasts, tumor incidence monitoring Molecular and cellular biology High 16135822
2006 RASSF1/NORE1 polypeptides bind MST1/2 through their SARAH domains; recombinant MST1/2 form spontaneous dimers and autoactivate in vitro by intradimer transphosphorylation of the activation loop (Thr183/Thr180); NORE1/RASSF polypeptides inhibit this autoactivation. The C. elegans RASSF ortholog (T24F1.3) also binds MST1/2 via SARAH domains. In vitro kinase reconstitution, SARAH domain binding assays, cross-species comparison Methods in enzymology High 16757333
2011 Rassf1 interacts with Daxx (co-immunoprecipitation) and partially co-localizes with Daxx during mitosis. Rassf1/Daxx depletion or expression of the Daxx-binding domain of Rassf1 elevates cyclin B stability and increases taxol resistance, defining a mitotic stress checkpoint. Rassf1 depletion does not alter APC/C ubiquitin ligase activity in vitro, indicating the checkpoint requires the mitotic cellular environment. Co-immunoprecipitation, RNAi knockdown, cyclin B stability assay, in vitro APC/C ubiquitin ligase assay, time-lapse microscopy, mouse xenograft Oncogene Medium 21643015
2013 RASSF family members (RASSF1-6) interact with MST kinases through SARAH domain-mediated interactions, confirmed by in vitro interaction studies; RASSF7 was identified as a new MST kinase interacting partner. RA domain interactions show diversity across RASSF members. RASSF proteins act as adaptors assembling multiple protein complexes. In vitro interaction studies (SARAH and RA domain), structural modeling, in silico prediction Advances in biological regulation Medium 23357313
2015 RASSF1A restricts SRC kinase activity and prevents motility/invasion, while the RASSF1C isoform (expressed when RASSF1A promoter is methylated) targets SRC/YES kinases to epithelial cell-cell junctions and promotes tyrosine phosphorylation of E-cadherin, β-catenin, and YAP1. RASSF1A promoter methylation reduces YAP phospho-S127, derepressing YAP1; this is identified by affinity proteomics, proximity ligation assay, and real-time molecular visualization. Affinity proteomics, proximity ligation assay, live-cell imaging, phosphorylation assays, in vitro and in vivo invasion/motility assays, promoter methylation analysis Current biology : CB High 26549256
2017 miR-193a-3p directly binds to the RASSF1 3'UTR and represses RASSF1 mRNA and protein expression; excess miR-193a-3p impairs the Rassf1-Syntaxin 16 signalling pathway required for cytokinesis completion, causing polyploidy, multipolar mitotic spindles, and elevated cell death. Dual luciferase reporter assay, immunoblotting, qRT-PCR, time-lapse microscopy, immunofluorescence British journal of cancer Medium 28449010
2019 RASSF1-AS1 (an antisense lncRNA from the RASSF1A locus) partially overlaps RASSF1A mRNA at exon 2 and directly binds RASSF1A mRNA, suppressing its translation at the post-transcriptional level. RNA pulldown and luciferase assays confirm this direct binding. Mutated RASSF1-AS1 lacking the binding region has no effect on RASSF1A expression or NF-κB activation. RNA pulldown, luciferase activity assay, overexpression/knockdown in mouse primary cardiac fibroblasts, Western blot Cell biology international Medium 30571844
2016 miR-181a directly targets RASSF1 (validated by luciferase assay), reducing RASSF1 expression; knockdown of RASSF1 increases sorafenib resistance in hepatocellular carcinoma cells, linking RASSF1 to MAPK signaling and sorafenib sensitivity. Luciferase reporter assay, miRNA overexpression/inhibition, RNAi knockdown, apoptosis assays Cancer science Medium 27384977
2016 rhBMP-2 increases MST1, MOB1, and p-YAP levels in esophageal cancer cells, and RASSF1 binding to MST1 is enhanced upon rhBMP-2 treatment. RASSF1 knockdown reverses the p-YAP induction by rhBMP-2, placing RASSF1 upstream of MST1 in rhBMP-2-activated Hippo signaling. Co-immunoprecipitation (RASSF1-MST1), siRNA knockdown, Western blot, MTT assay, xenograft Scientific reports Medium 27230238
2023 ATF4 directly binds to ATF4-binding sites in the RASSF1 promoter (shown by ChIP) and activates RASSF1 transcription (shown by reporter assay). RASSF1 ablation mitigates expression of the ATF4 effector BBC3 and abrogates tunicamycin-induced apoptosis, placing RASSF1 downstream of ATF4 in ER stress-associated apoptosis. Chromatin immunoprecipitation (ChIP), luciferase reporter assay, RASSF1 knockdown, tunicamycin-induced apoptosis assay FEBS open bio Medium 36723232
2024 P. multocida infection upregulates Rassf1 expression in pulmonary epithelial cells; Rassf1 enhances Hippo-YAP pathway through phosphorylation (increased p-MST1/2, p-LATS1, p-YAP). In vitro knockdown of Rassf1 enhances YAP activity and reduces apoptosis during infection, and pharmacological Hippo inhibition rescues apoptosis in vitro and reduces lung injury in vivo. RNA-seq, siRNA knockdown, Western blot for pathway phosphorylation, mouse and rabbit infection models, pharmacological inhibition (XMU-MP-1) Veterinary research Medium 38493147
2025 RFX2 transcription factor binds directly to the RASSF1 promoter (shown by dual-luciferase and ChIP assays) and activates RASSF1 transcription. RASSF1 knockdown reverses the ability of RFX2 overexpression to inhibit immune escape, placing RASSF1 downstream of RFX2 in Hippo/YAP-mediated immune regulation. Dual-luciferase reporter assay, ChIP-PCR, siRNA knockdown, co-culture with CD8+ T cells, Western blot for YAP phosphorylation Cell division Medium 40069841

Source papers

Stage 0 corpus · 58 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. The Biochemical journal 303 15109305
2000 Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. The Journal of biological chemistry 247 10998413
2005 The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Molecular and cellular biology 92 16135822
2004 Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). The Journal of biological chemistry 89 15145946
2002 RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene 88 11965544
2010 PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients. International journal of cancer 79 19795445
2020 CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1. Cancer management and research 74 32104074
2006 Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases. Methods in enzymology 67 16757333
2016 miR-181a induces sorafenib resistance of hepatocellular carcinoma cells through downregulation of RASSF1 expression. Cancer science 64 27384977
2015 Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion. Current biology : CB 63 26549256
2005 Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5. Cancer research 51 15753381
2002 Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. In vitro cellular & developmental biology. Animal 51 12762840
2019 Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer. International journal of molecular sciences 48 31547587
2011 Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. Epigenetics 36 22139571
2010 Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung. Anticancer research 36 21036752
2018 Methylation of L1RE1, RARB, and RASSF1 function as possible biomarkers for the differential diagnosis of lung cancer. PloS one 34 29851970
2013 Comparative analysis of interactions of RASSF1-10. Advances in biological regulation 32 23357313
2011 Regulation of mitosis and taxane response by Daxx and Rassf1. Oncogene 29 21643015
2009 High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. PloS one 26 19478941
2020 Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAFV600E mutation as biomarkers for papillary thyroid carcinoma. Journal of cellular physiology 25 32017063
2014 Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer. Journal of cancer research and clinical oncology 25 24938434
2013 The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis. Molecular biology international 24 24327924
2005 Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk. Cancer letters 24 16125301
2005 Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein. Biochemical and biophysical research communications 23 15907802
2020 SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1. Cancer cell international 19 33292299
2009 Methylation analysis of BRCA1, RASSF1, GSTP1 and EPHB2 promoters in prostate biopsies according to different degrees of malignancy. In vivo (Athens, Greece) 18 19454503
2016 RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes. BMC cancer 17 26754001
2016 SMARCB1/INI1-deficient sinonasal carcinoma shows methylation of RASSF1 gene: A clinicopathological, immunohistochemical and molecular genetic study of a recently described entity. Pathology, research and practice 17 28069272
2020 Danhong Injection Alleviates Cardiac Fibrosis via Preventing the Hypermethylation of Rasal1 and Rassf1 in TAC Mice. Oxidative medicine and cellular longevity 16 33456666
2019 RETRACTED: Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A. Molecules (Basel, Switzerland) 16 31623109
2011 Frequent methylation of RASSF1 and RARB in urine sediments from patients with early stage prostate cancer. Medicina (Kaunas, Lithuania) 16 21822036
2016 RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells. Scientific reports 13 27230238
2013 GCPII modulates oxidative stress and prostate cancer susceptibility through changes in methylation of RASSF1, BNIP3, GSTP1 and Ec-SOD. Molecular biology reports 13 23979608
2012 RASSF1 Polymorphisms in Cancer. Molecular biology international 12 22701175
2024 Pasteurella multocida activates Rassf1-Hippo-Yap pathway to induce pulmonary epithelial apoptosis. Veterinary research 11 38493147
2019 RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice. Cell biology international 11 30571844
2019 RASSF1 promotes cardiomyocyte apoptosis after acute myocardial infarction and is regulated by miR-125b. Journal of cellular biochemistry 10 31595551
2018 EGFL7 and RASSF1 promoter hypermethylation in epithelial ovarian cancer. Cancer genetics 10 29778234
2017 Excess of a Rassf1-targeting microRNA, miR-193a-3p, perturbs cell division fidelity. British journal of cancer 9 28449010
2020 The Role of RASSF1 Methylation in Lung Carcinoma. Advances in experimental medicine and biology 7 32949393
2015 The investigation of GSTP1, APC and RASSF1 gene promoter hypermethylation in urine DNA of prostate-diseased patients. Bratislavske lekarske listy 7 25665470
2013 High-resolution melting-based quantitative analysis of RASSF1 methylation in breast cancer. Medicina (Kaunas, Lithuania) 7 23888343
2009 The association between RASSF1 gene polymorphisms and lung cancer susceptibility among people in Hubei Province of China. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 5 19821102
2023 Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients. Hormone molecular biology and clinical investigation 4 36584330
2023 An Optimized CoBRA Method for the Microfluidic Electrophoresis Detection of Breast Cancer Associated RASSF1 Methylation. Biotech (Basel (Switzerland)) 4 36648833
2022 Cell-free methylation of RASSF1 and CDKN2AIP genes in the diagnosis of hepatocellular carcinoma associated with hepatitis B virus cirrhosis. Hepatology forum 3 36177104
2006 Molecular alterations of monophasic synovial sarcoma: loss of chromosome 3p does not alter RASSF1 and MLH1 transcriptional activity. Histology and histopathology 3 16329043
2019 Circulating tumor DNA RASSF1 methylation for predicting cancer risk: a diagnostic meta-analysis. Future oncology (London, England) 2 31578881
2016 [GSTP1, APC and RASSF1 gene methylation in prostate cancer samples: comparative analysis of MS-HRM method and Infinium HumanMethylation450 BeadChip beadchiparray diagnostic value]. Biomeditsinskaia khimiia 2 28026816
2025 RFX2 downregulates RASSF1 expression and YAP phosphorylation through Hippo signaling to promote immune escape in lung adenocarcinoma. Cell division 1 40069841
2025 Ras association domain family member 1 (RASSF1): Molecular characteristics, clinical relevance and therapeutic interventions in cancer. Biochimica et biophysica acta. Molecular basis of disease 1 40645298
2025 RETRACTED: Waheed et al. Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A. Molecules 2019, 24, 3722. Molecules (Basel, Switzerland) 1 41217138
2026 Transcript-Specific DNA Methylation Alterations of the RASSF1 Locus in Cancer Cells. Genes, chromosomes & cancer 0 42010802
2025 Genetic Variants in RASSF1 (rs2073498), SERPINE1 (rs1799889), and EFNA1 (rs12904) Are Associated with Susceptibility in Mexican Patients with Colorectal Cancer: Clinical Associations and Their Analysis In Silico. Genes 0 40004552
2025 Expression of G-quadruplex coordinates BRCA1, CDH1, and RASSF1 via DNA methylation in mouse breast cancer cells. Epigenomics 0 41133888
2023 RASSF1 is identified by transcriptome coordination analysis as a target of ATF4. FEBS open bio 0 36723232
2022 Association of Variants in COMT, RASSF1 and GPM6A with the Risk of Paranoid Schizophrenia Patients in Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia. The Malaysian journal of medical sciences : MJMS 0 35528814
2003 [Expression of different RASSF1 transcripts and its clinical significance in lung carcinoma]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 0 12795841