Affinage

RASSF1

Ras association domain-containing protein 1 · UniProt Q9NS23

Length
344 aa
Mass
39.2 kDa
Annotated
2026-06-10
59 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RASSF1 is a scaffold tumor suppressor that couples Ras signaling to apoptosis and to the Hippo kinase cascade, and whose loss—frequently by promoter methylation—drives tumorigenesis (PMID:10998413, PMID:16135822). The RASSF1A isoform binds activated Ras-GTP and mediates Ras-dependent, caspase-dependent apoptosis (PMID:10998413), and Rassf1A-null mice show increased spontaneous and irradiation-induced tumors, establishing the gene as a bona fide tumor suppressor (PMID:16135822). RASSF1 engages MST1/2 kinases through reciprocal SARAH-domain interactions, and depending on context it both restrains MST autoactivation in vitro (PMID:15109305, PMID:16757333) and serves as a proximal activator of the Hippo cascade (MST1/2→LATS1→phospho-YAP) in response to upstream cues including BMP2, ursolic acid, and bacterial infection (PMID:31547587, PMID:27230238, PMID:38493147). Beyond the Hippo axis, RASSF1A stabilizes microtubules—conferring isoform-specific behavior through C19ORF5 interaction—and Rassf1A-null cells are hypersensitive to microtubule-depolymerizing agents (PMID:15753381, PMID:16135822); RASSF1 also forms a Daxx-dependent mitotic stress checkpoint controlling cyclin B stability and taxol response (PMID:21643015), and supports cytokinesis via a Syntaxin 16 pathway (PMID:28449010). RASSF1A restricts SRC kinase activity at epithelial junctions, and epigenetic switching to the RASSF1C isoform redirects SRC/YES to promote E-cadherin/β-catenin/YAP1 tyrosine phosphorylation and nuclear YAP1-driven invasion (PMID:26549256). The locus is transcriptionally activated by ATF4 during ER stress to promote apoptosis (PMID:36723232) and by RFX2 (PMID:40069841), and is suppressed by SKP1 and by miR-193a-3p targeting its 3'UTR (PMID:33292299, PMID:28449010).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2000 High

    Established that RASSF1 is a direct Ras effector linking Ras-GTP to apoptosis, defining its core tumor-suppressive function.

    Evidence Co-IP, in vitro GST pulldown, dominant-negative/activated Ras co-transfection, and caspase-inhibitor rescue in transfected cells

    PMID:10998413

    Open questions at the time
    • Did not resolve the downstream apoptotic effectors
    • Ras-binding affinity quantitation absent
  2. 2004 High

    Showed RASSF1 binds MST1/2 via SARAH domains and inhibits their autoactivation, and physically couples to PMCA4b to dampen EGF-ERK signaling, defining its scaffold role over kinase activity.

    Evidence Endogenous Co-IP, in vitro kinase autoactivation assays, yeast two-hybrid and domain-mapping with competing peptide

    PMID:15109305 PMID:15145946

    Open questions at the time
    • Reconciliation of MST inhibition with later Hippo-activating role not addressed
    • Cellular conditions governing activation versus inhibition unclear
  3. 2005 High

    Defined RASSF1A as a microtubule-stabilizing tumor suppressor and demonstrated isoform-specific behavior conferred by the N-terminus and C19ORF5.

    Evidence Isoform overexpression with C19ORF5 co-expression, domain deletion, microtubule assays, and Rassf1A knockout mouse with tumor incidence and depolymerizer sensitivity readouts

    PMID:15753381 PMID:16135822

    Open questions at the time
    • Mechanism linking microtubule stabilization to tumor suppression in vivo not fully resolved
    • C19ORF5 binding interface not structurally defined
  4. 2006 Medium

    Refined the binding model: RASSF1 SARAH domains mediate MST1/2 inhibition while RASSF1 itself has low intrinsic Ras-GTP affinity, possibly engaging Ras indirectly via Nore1.

    Evidence In vitro kinase assays with recombinant SARAH polypeptides and GTPase binding assays

    PMID:16757333

    Open questions at the time
    • Indirect Ras association via Nore1 not validated in cells
    • Methods/review-format limits independent confirmation
  5. 2011 Medium

    Identified a Daxx-RASSF1 mitotic stress checkpoint controlling cyclin B stability and taxol sensitivity, extending RASSF1 function into mitotic surveillance.

    Evidence Co-IP, siRNA, time-lapse microscopy, cyclin B stability assay, and xenograft taxol response

    PMID:21643015

    Open questions at the time
    • Molecular mechanism by which Daxx-RASSF1 controls cyclin B undefined
    • Single-lab finding
  6. 2013 Low

    Generalized SARAH-mediated MST binding across the RASSF family and identified non-canonical MST partners.

    Evidence In vitro interaction studies with computational structural modeling

    PMID:23357313

    Open questions at the time
    • In vitro binding without mutagenesis or structural validation
    • Partially computational
  7. 2015 High

    Demonstrated that RASSF1A restricts SRC at epithelial junctions and that epigenetic switching to RASSF1C redirects SRC/YES to drive YAP1-mediated invasion, explaining functional antagonism between isoforms.

    Evidence Affinity proteomics, proximity ligation, live imaging, shRNA/overexpression, invasion assays, in vivo tumorigenesis and phospho-westerns

    PMID:26549256

    Open questions at the time
    • Triggers governing promoter switching not defined
    • Direct SRC-RASSF1 contact mechanism not structurally resolved
  8. 2016 Medium

    Recast RASSF1 as a proximal Hippo activator: BMP2 increases RASSF1-MST1 binding and RASSF1 is required for BMP2-induced YAP phosphorylation.

    Evidence Co-IP upon BMP2 treatment, siRNA, phospho-westerns, xenograft

    PMID:27230238

    Open questions at the time
    • Mechanism reconciling activation with earlier MST inhibition unresolved
    • Single lineage tested
  9. 2017 Medium

    Placed RASSF1 under post-transcriptional control by miR-193a-3p and linked it to cytokinesis via Syntaxin 16.

    Evidence Luciferase 3'UTR reporter, immunoblot, qRT-PCR, time-lapse microscopy

    PMID:28449010

    Open questions at the time
    • RASSF1-Syntaxin 16 biochemical interaction not detailed
    • Single-lab finding
  10. 2019 Medium

    Confirmed epistatically that RASSF1 acts upstream of MST1/2-LATS1 in YAP phosphorylation in response to ursolic acid.

    Evidence siRNA knockdown reversing p-YAP, microarray/GO analysis, westerns, xenograft

    PMID:31547587

    Open questions at the time
    • Direct contribution versus indirect signaling not separated
    • Single cancer type
  11. 2023 Medium

    Defined transcriptional control of RASSF1 by ATF4 during ER stress, integrating RASSF1 into stress-induced apoptosis.

    Evidence ChIP, luciferase reporter, RASSF1 ablation, tunicamycin-induced apoptosis

    PMID:36723232

    Open questions at the time
    • Whether ER-stress apoptosis operates through Hippo or Ras arms unclear
    • Single-lab finding
  12. 2024 Medium

    Showed RASSF1 is induced during bacterial infection and drives Hippo-mediated pulmonary epithelial apoptosis, extending its role to host-pathogen responses.

    Evidence RNA-seq, siRNA, pharmacological Hippo inhibition, mouse and rabbit infection models, phospho-westerns

    PMID:38493147

    Open questions at the time
    • Upstream sensor coupling infection to RASSF1 induction unknown
    • Direct versus indirect kinase activation not separated
  13. 2025 Medium

    Identified RFX2 as a transcriptional activator of RASSF1 governing Hippo-dependent immune escape in lung adenocarcinoma, and SKP1 (2020) as a suppressor of RASSF1 controlling YAP and stemness.

    Evidence Dual-luciferase, ChIP-PCR, siRNA/overexpression epistasis, CD8+ T-cell co-culture, xenografts

    PMID:33292299 PMID:40069841

    Open questions at the time
    • Mechanism of SKP1-mediated RASSF1 suppression at mRNA and protein levels not unified
    • Immune-escape link mechanistically indirect

Open questions

Synthesis pass · forward-looking unresolved questions
  • The conditions that toggle RASSF1 between inhibiting MST autoactivation and activating the MST1/2-LATS1-YAP cascade, and the molecular trigger for RASSF1A-to-RASSF1C promoter switching, remain unresolved.
  • No unified model reconciles RASSF1 as both MST inhibitor and Hippo activator
  • Structural basis of isoform-specific partner selection undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0008092 cytoskeletal protein binding 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1640170 Cell Cycle 2
Partners
DAXXLATS1MST1MST2PMCA4BRASSRCYAP1

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 RASSF1 binds Ras in a GTP-dependent manner both in vivo and directly in vitro, and activated Ras enhances while dominant-negative Ras inhibits RASSF1-induced apoptosis; RASSF1-transfected cells exhibit membrane blebbing rescued by caspase inhibitor, establishing RASSF1 as a Ras effector mediating apoptosis. Co-immunoprecipitation, in vitro GST pulldown, dominant-negative/activated Ras co-transfection, caspase inhibitor rescue assay The Journal of biological chemistry High 10998413
2004 Endogenous MST1 in KB cells is specifically associated with substoichiometric amounts of RASSF1A. Co-expression of RASSF1A (and RASSF1C) with MST1 markedly suppresses MST1(Thr183) autophosphorylation in vivo and abolishes Mg-ATP-mediated MST1 autoactivation in vitro, establishing RASSF1 as an inhibitor of MST1/2 kinase autoactivation through direct association via SARAH domains. Co-immunoprecipitation of endogenous proteins, in vitro kinase autoactivation assay with recombinant proteins, in vivo co-transfection phosphorylation assay The Biochemical journal High 15109305
2004 RASSF1 (via region 74-123 of RASSF1C / 144-193 of RASSF1A) physically interacts with the catalytic second intracellular loop (region 652-748) of plasma membrane calcium ATPase PMCA4b, and this interaction inhibits EGF-dependent ERK pathway activation; blocking the interaction with a competing GFP-fusion peptide abolishes the inhibition. Yeast two-hybrid screen, co-immunoprecipitation, GST pulldown, immunofluorescence co-localization, domain-mapping with competing peptide, ERK signaling assay The Journal of biological chemistry High 15145946
2005 RASSF1A (but not RASSF1C when co-expressed with C19ORF5) causes paclitaxel-like microtubule hyperstabilization and disruption of mitosis; both isoforms share identical microtubule association domains, but the unique N-terminal sequence of RASSF1C prevents it from hyperstabilizing microtubules when C19ORF5 is present, conferring isoform-specific specificity on RASSF1A in microtubule hyperstabilization. Transfection/overexpression of isoforms, microtubule stabilization assays, co-expression with C19ORF5, domain deletion analysis Cancer research Medium 15753381
2005 RASSF1A promotes microtubule stability in vivo; Rassf1A null mouse embryonic fibroblasts show increased sensitivity to microtubule depolymerizing agents, and Rassf1A null mice exhibit increased spontaneous and irradiation-induced tumorigenesis, establishing RASSF1A as a bona fide tumor suppressor that maintains microtubule integrity. Targeted gene knockout in mouse, microtubule depolymerization sensitivity assay in primary fibroblasts, in vivo tumor incidence monitoring Molecular and cellular biology High 16135822
2006 RASSF1 polypeptides bind MST1 and MST2 through the SARAH domains of each partner; recombinant RASSF1/Nore1 polypeptides inhibit MST1/2 intradimer transphosphorylation autoactivation in vitro. Additionally, RASSF1 exhibits relatively low affinity for Ras-like GTPases directly but may associate with Ras-GTP indirectly (via Nore1), in contrast to Nore1A which binds Ras-GTP with high affinity. In vitro kinase assay with recombinant proteins, SARAH domain interaction studies, Ras GTPase binding assays Methods in enzymology Medium 16757333
2011 RASSF1 interacts with Daxx during mitosis and partially co-localizes with Daxx; co-depletion or expression of the Daxx-binding domain of Rassf1 stabilizes cyclin B and increases taxol resistance, defining a Daxx-Rassf1 mitotic stress checkpoint that enables cells to exit mitosis as micronucleated cells when encountering taxol. Co-immunoprecipitation, siRNA knockdown, time-lapse microscopy, cyclin B stability assay, mouse xenograft taxol response assay Oncogene Medium 21643015
2013 RASSF family members (RASSF1-6) interact with MST kinases through SARAH domain-mediated interactions consistent with structural predictions; in vitro interaction studies confirm RASSF1 SARAH domain binding to MST kinase SARAH domain. RASSF7, lacking a canonical SARAH domain, was identified as a new MST kinase interacting partner. In vitro interaction studies, computational structural modeling, in silico RA and SARAH domain comparative analysis Advances in biological regulation Low 23357313
2015 RASSF1A restricts SRC kinase activity and prevents motility/invasion; loss of RASSF1A by promoter methylation switches transcription to RASSF1C, which targets SRC/YES to epithelial cell-cell junctions, promotes tyrosine phosphorylation of E-cadherin, β-catenin, and YAP1, and derepresses YAP1 (via reduced YAP pS127), enabling nuclear YAP1-mediated transcription of invasion genes. RASSF1A methylation correlates with increased inhibitory pY527-SRC. Affinity proteomics, proximity ligation assay, real-time molecular visualization, shRNA knockdown, overexpression, in vitro invasion/motility assays, in vivo tumorigenesis models, phospho-western blotting Current biology : CB High 26549256
2017 miR-193a-3p directly binds the RASSF1 3'UTR and represses RASSF1 mRNA and protein expression; excess miR-193a-3p impairs the Rassf1-Syntaxin 16 signaling pathway required for cytokinesis completion, causing polyploidy, multipolar spindles, and elevated cell death. Luciferase reporter assay (direct 3'UTR binding), immunoblotting, qRT-PCR, time-lapse microscopy, immunofluorescence British journal of cancer Medium 28449010
2019 RASSF1 functions as an upstream activator of the Hippo pathway; ursolic acid upregulates RASSF1, which activates MST1, MST2, and LATS1, leading to YAP phosphorylation (p-YAP); RASSF1 silencing reverses UA-induced p-YAP expression, placing RASSF1 upstream of MST kinases in the Hippo cascade in gastric cancer cells. siRNA knockdown of RASSF1, microarray/gene ontology analysis, Western blotting for Hippo pathway components, xenograft in vivo model International journal of molecular sciences Medium 31547587
2016 RhBMP-2 increases RASSF1 binding to MST1, activates Hippo signaling (increases MST1, MOB1, p-YAP), and RASSF1 knockdown reverses BMP2-induced p-YAP, establishing RASSF1 as necessary for BMP2-mediated Hippo pathway activation in esophageal cancer cells. Co-immunoprecipitation (RASSF1-MST1 binding upon BMP2 treatment), siRNA knockdown of RASSF1, Western blotting for p-YAP and Hippo components, in vivo xenograft Scientific reports Medium 27230238
2024 P. multocida infection upregulates Rassf1 expression, and Rassf1 enhances Hippo-Yap pathway through phosphorylation of Mst1/2 and Lats1; in vitro knockdown of Rassf1 significantly enhanced Yap activity and reduced apoptosis during infection, confirming Rassf1 as a proximal activator of the Hippo kinase cascade leading to pulmonary epithelial apoptosis. RNA-seq, siRNA knockdown, pharmacological Hippo inhibition (XMU-MP-1), mouse and rabbit infection models, Western blotting for p-Mst1/2, p-Lats1, p-Yap Veterinary research Medium 38493147
2023 ATF4 transcription factor binds operational binding sites in the RASSF1 promoter (demonstrated by ChIP) and activates RASSF1 transcription (demonstrated by reporter assay); RASSF1 ablation mitigates ATF4 effector BBC3 expression and abrogates tunicamycin-induced (ER stress) apoptosis, placing RASSF1 downstream of ATF4 in ER stress-associated apoptosis. Chromatin immunoprecipitation (ChIP), luciferase reporter assay, RASSF1 knockdown/ablation, tunicamycin-induced apoptosis assay FEBS open bio Medium 36723232
2025 RFX2 transcription factor binds the RASSF1 promoter and activates RASSF1 transcription; RASSF1 knockdown reverses RFX2-mediated inhibition of immune escape and YAP phosphorylation, placing RASSF1 downstream of RFX2 in the Hippo pathway in lung adenocarcinoma. Dual-luciferase assay, ChIP-PCR (RFX2 enrichment at RASSF1 promoter), siRNA knockdown of RASSF1, co-culture with CD8+ T cells, in vivo tumor model Cell division Medium 40069841
2020 SKP1 suppresses RASSF1 at both mRNA and protein levels; RASSF1 overexpression abolishes SKP1-driven YAP activation and cancer stem cell stemness, placing RASSF1 as a downstream mediator of SKP1's effect on Hippo-YAP signaling in colorectal cancer cells. Lentiviral overexpression and knockdown, Western blotting, luciferase reporter, ChIP-PCR, nuclear run-on assay, Co-IP, sphere formation, xenograft Cancer cell international Medium 33292299

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. The Biochemical journal 303 15109305
2000 Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. The Journal of biological chemistry 247 10998413
2005 The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Molecular and cellular biology 92 16135822
2004 Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). The Journal of biological chemistry 89 15145946
2002 RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene 88 11965544
2010 PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients. International journal of cancer 79 19795445
2020 CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1. Cancer management and research 76 32104074
2006 Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases. Methods in enzymology 67 16757333
2016 miR-181a induces sorafenib resistance of hepatocellular carcinoma cells through downregulation of RASSF1 expression. Cancer science 64 27384977
2015 Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion. Current biology : CB 63 26549256
2005 Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5. Cancer research 51 15753381
2002 Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. In vitro cellular & developmental biology. Animal 51 12762840
2019 Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer. International journal of molecular sciences 48 31547587
2011 Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. Epigenetics 36 22139571
2010 Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung. Anticancer research 36 21036752
2018 Methylation of L1RE1, RARB, and RASSF1 function as possible biomarkers for the differential diagnosis of lung cancer. PloS one 34 29851970
2013 Comparative analysis of interactions of RASSF1-10. Advances in biological regulation 32 23357313
2011 Regulation of mitosis and taxane response by Daxx and Rassf1. Oncogene 30 21643015
2009 High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. PloS one 26 19478941
2020 Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAFV600E mutation as biomarkers for papillary thyroid carcinoma. Journal of cellular physiology 25 32017063
2014 Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer. Journal of cancer research and clinical oncology 25 24938434
2013 The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis. Molecular biology international 25 24327924
2005 Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk. Cancer letters 24 16125301
2005 Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein. Biochemical and biophysical research communications 23 15907802
2020 SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1. Cancer cell international 20 33292299
2016 RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes. BMC cancer 18 26754001
2016 SMARCB1/INI1-deficient sinonasal carcinoma shows methylation of RASSF1 gene: A clinicopathological, immunohistochemical and molecular genetic study of a recently described entity. Pathology, research and practice 18 28069272
2009 Methylation analysis of BRCA1, RASSF1, GSTP1 and EPHB2 promoters in prostate biopsies according to different degrees of malignancy. In vivo (Athens, Greece) 18 19454503
2020 Danhong Injection Alleviates Cardiac Fibrosis via Preventing the Hypermethylation of Rasal1 and Rassf1 in TAC Mice. Oxidative medicine and cellular longevity 17 33456666
2019 RETRACTED: Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A. Molecules (Basel, Switzerland) 16 31623109
2011 Frequent methylation of RASSF1 and RARB in urine sediments from patients with early stage prostate cancer. Medicina (Kaunas, Lithuania) 16 21822036
2024 Pasteurella multocida activates Rassf1-Hippo-Yap pathway to induce pulmonary epithelial apoptosis. Veterinary research 13 38493147
2016 RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells. Scientific reports 13 27230238
2013 GCPII modulates oxidative stress and prostate cancer susceptibility through changes in methylation of RASSF1, BNIP3, GSTP1 and Ec-SOD. Molecular biology reports 13 23979608
2012 RASSF1 Polymorphisms in Cancer. Molecular biology international 12 22701175
2019 RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice. Cell biology international 11 30571844
2019 RASSF1 promotes cardiomyocyte apoptosis after acute myocardial infarction and is regulated by miR-125b. Journal of cellular biochemistry 11 31595551
2018 EGFL7 and RASSF1 promoter hypermethylation in epithelial ovarian cancer. Cancer genetics 10 29778234
2017 Excess of a Rassf1-targeting microRNA, miR-193a-3p, perturbs cell division fidelity. British journal of cancer 9 28449010
2020 The Role of RASSF1 Methylation in Lung Carcinoma. Advances in experimental medicine and biology 8 32949393
2015 The investigation of GSTP1, APC and RASSF1 gene promoter hypermethylation in urine DNA of prostate-diseased patients. Bratislavske lekarske listy 7 25665470
2013 High-resolution melting-based quantitative analysis of RASSF1 methylation in breast cancer. Medicina (Kaunas, Lithuania) 7 23888343
2009 The association between RASSF1 gene polymorphisms and lung cancer susceptibility among people in Hubei Province of China. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 5 19821102
2023 Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients. Hormone molecular biology and clinical investigation 4 36584330
2023 An Optimized CoBRA Method for the Microfluidic Electrophoresis Detection of Breast Cancer Associated RASSF1 Methylation. Biotech (Basel (Switzerland)) 4 36648833
2022 Cell-free methylation of RASSF1 and CDKN2AIP genes in the diagnosis of hepatocellular carcinoma associated with hepatitis B virus cirrhosis. Hepatology forum 3 36177104
2006 Molecular alterations of monophasic synovial sarcoma: loss of chromosome 3p does not alter RASSF1 and MLH1 transcriptional activity. Histology and histopathology 3 16329043
2025 RFX2 downregulates RASSF1 expression and YAP phosphorylation through Hippo signaling to promote immune escape in lung adenocarcinoma. Cell division 2 40069841
2025 Ras association domain family member 1 (RASSF1): Molecular characteristics, clinical relevance and therapeutic interventions in cancer. Biochimica et biophysica acta. Molecular basis of disease 2 40645298
2019 Circulating tumor DNA RASSF1 methylation for predicting cancer risk: a diagnostic meta-analysis. Future oncology (London, England) 2 31578881
2016 [GSTP1, APC and RASSF1 gene methylation in prostate cancer samples: comparative analysis of MS-HRM method and Infinium HumanMethylation450 BeadChip beadchiparray diagnostic value]. Biomeditsinskaia khimiia 2 28026816
2025 RETRACTED: Waheed et al. Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A. Molecules 2019, 24, 3722. Molecules (Basel, Switzerland) 1 41217138
2026 Transcript-Specific DNA Methylation Alterations of the RASSF1 Locus in Cancer Cells. Genes, chromosomes & cancer 0 42010802
2026 Key Molecular Events in PM2.5-Induced Lung Injury: Autophagy and Ferroptosis Mediated by the miR-212-5p/RASSF1 Axis. Cells 0 42121925
2025 Genetic Variants in RASSF1 (rs2073498), SERPINE1 (rs1799889), and EFNA1 (rs12904) Are Associated with Susceptibility in Mexican Patients with Colorectal Cancer: Clinical Associations and Their Analysis In Silico. Genes 0 40004552
2025 Expression of G-quadruplex coordinates BRCA1, CDH1, and RASSF1 via DNA methylation in mouse breast cancer cells. Epigenomics 0 41133888
2023 RASSF1 is identified by transcriptome coordination analysis as a target of ATF4. FEBS open bio 0 36723232
2022 Association of Variants in COMT, RASSF1 and GPM6A with the Risk of Paranoid Schizophrenia Patients in Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia. The Malaysian journal of medical sciences : MJMS 0 35528814
2003 [Expression of different RASSF1 transcripts and its clinical significance in lung carcinoma]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 0 12795841

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