Affinage

RAB3B

Ras-related protein Rab-3B · UniProt P20337

Length
219 aa
Mass
24.8 kDa
Annotated
2026-06-10
33 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB3B is a monomeric Rab GTPase that acts as a context-dependent regulator of vesicle trafficking and regulated exocytosis, functioning downstream of Ca2+ influx in secretory and neuroendocrine cells (PMID:8393147, PMID:9659290). In neuroendocrine cells it targets to large dense-core secretory vesicles and binds the effector rabphilin-3A in a GTP-dependent manner, and—distinct from the closely related Rab3A—it potently stimulates Ca2+-evoked catecholamine secretion and vesicular cargo accumulation, establishing non-redundant isoform-specific roles (PMID:8636125, PMID:16822953). In epithelial cells RAB3B governs polarized membrane traffic: GTP-bound RAB3B directly binds the cytoplasmic tail of the polymeric immunoglobulin receptor to control ligand-stimulated transcytosis (PMID:11832247), regulates basolateral vesicle transport (PMID:12901864), and recruits the effector Noc2 to perinuclear membranes (PMID:15003533). At hippocampal inhibitory synapses RAB3B is enriched presynaptically and is required for endocannabinoid-dependent long-term depression through a Rab3/RIM-dependent pathway involving GTP-dependent binding to RIM1α/RIM2α (PMID:21844341). Beyond canonical effectors, RAB3B binds calmodulin in a Ca2+-dependent manner (PMID:11741295) and is phosphorylated upon secretagogue stimulation (PMID:8356066). In cancer contexts RAB3B promotes tumor aggressiveness and stemness by stabilizing DDX6 (PMID:38834947) and by binding the phosphatase DUSP12 to block dephosphorylation of ribosomal protein S6, thereby sustaining mTORC1/S6 signaling (PMID:40135815).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1993 High

    Established RAB3B as a functional regulator of regulated exocytosis rather than endocytosis, defining its position downstream of Ca2+-dependent secretory machinery.

    Evidence Antisense oligonucleotide knockdown in rat anterior pituitary cells with electrophysiological exocytosis monitoring

    PMID:8393147

    Open questions at the time
    • No effector or molecular partner identified
    • Mechanism downstream of Ca2+ not defined
  2. 1993 Medium

    Linked RAB3B to active secretion by showing secretagogue-induced phosphorylation, raising the possibility of post-translational regulation of its cycling.

    Evidence Subcellular fractionation and phosphorylation assay in thrombin-stimulated human platelets with PGE1 controls

    PMID:8356066

    Open questions at the time
    • Responsible kinase unidentified
    • Functional consequence of phosphorylation not tested
  3. 1996 High

    Resolved how RAB3B differs from Rab3A despite shared vesicle targeting and effector binding, demonstrating isoform-specific functional output in secretion.

    Evidence Stable expression in PC12 cells, membrane fractionation, GTP-dependent rabphilin-3A pull-down, and [3H]NE release assay with mutant analysis

    PMID:8636125

    Open questions at the time
    • Basis for opposite functional effects of Rab3A vs Rab3B unexplained
    • Effector beyond rabphilin-3A unknown at this stage
  4. 1997 Medium

    Identified biochemical and localization divergence of RAB3B from its paralogs, revealing markedly lower GTP affinity and plasma-membrane targeting.

    Evidence GTP[S] binding assays, C-terminal truncation/swap mutagenesis, and immunofluorescence in bovine chromaffin cells

    PMID:9164844

    Open questions at the time
    • Functional consequence of low GTP affinity unresolved
    • Single-lab biochemistry
  5. 1998 Medium

    Confirmed RAB3B operates downstream of cytosolic Ca2+ elevation in physiological hormone exocytosis, separating its role from Ca2+ signaling itself.

    Evidence Antisense knockdown in gonadotrophs with radioimmunoassay for GnRH-induced hormone release and Ca2+ imaging

    PMID:9659290

    Open questions at the time
    • Molecular step controlled by RAB3B not defined
    • Effector involvement not tested
  6. 2000 Medium

    Distinguished two separable RAB3B activities—junctional protein/cytoskeletal remodeling versus secretion—mapping them to PI3-kinase-dependent and independent mechanisms.

    Evidence Stable expression of RAB3B, Rab3A and GTP-binding mutant in PC12 cells with F-actin/ZO-1 immunofluorescence, PI3K inhibitors, and secretion assay

    PMID:10854049

    Open questions at the time
    • Direct effector linking RAB3B to PI3K signaling unidentified
    • Relevance to native cell biology unclear
  7. 2001 Medium

    Identified calmodulin as a Ca2+-dependent, nucleotide-independent RAB3B interactor, providing a candidate sensor coupling RAB3B to Ca2+ signals.

    Evidence Reciprocal GST pull-downs and Sepharose-CaM bead assays from human platelet extracts with EGTA controls

    PMID:11741295

    Open questions at the time
    • Functional role of CaM binding untested
    • Binding interface not mapped
  8. 2002 High

    Demonstrated a direct RAB3B-cargo receptor interaction controlling polarized epithelial trafficking, expanding RAB3B function to transcytosis.

    Evidence Co-IP, direct binding to pIgR cytoplasmic domain, Arg657 mutagenesis, and transcytosis assay with GTP-locked RAB3B in MDCK cells

    PMID:11832247

    Open questions at the time
    • GTP-hydrolysis requirement only partially resolved
    • GEF/GAP regulating the cycle unidentified
  9. 2003 Medium

    Generalized RAB3B's epithelial role to selective basolateral vesicle transport, distinguishing it from apical and tight-junction routes.

    Evidence Overexpression of dominant-negative/constitutively active RAB3B in fibroblasts with cell-surface transport assays for LDLR, p75NTR, and Claudin-1

    PMID:12901864

    Open questions at the time
    • Effectors mediating basolateral specificity not identified
    • Single functional readout
  10. 2004 Medium

    Identified Noc2 as a GTP-dependent RAB3B effector in epithelial transport, providing a recruitment mechanism for basolateral cargo delivery.

    Evidence GST pull-down, co-expression translocation assay, and basolateral VSV-G transport assay

    PMID:15003533

    Open questions at the time
    • Direct binding interface not mapped
    • Endogenous requirement not tested by loss-of-function
  11. 2006 High

    Established strict non-redundancy between Rab3A and RAB3B in regulated exocytosis, showing cell-type-specific division of labor.

    Evidence Antisense knockdown, recombinant protein injection, mutant analysis, and patch-clamp capacitance in rat melanotrophs

    PMID:16822953

    Open questions at the time
    • Molecular determinants of isoform specificity unresolved
    • Differing effector usage not delineated
  12. 2009 Medium

    Extended RAB3B function to endosomal recycling and immune antigen cross-presentation, identifying a Rab3b/3c-positive recycling compartment.

    Evidence siRNA Rab GTPase screen, MHC-I tracing, co-localization, and transferrin recycling assays in dendritic cells

    PMID:19717423

    Open questions at the time
    • RAB3B and RAB3C contributions not separated
    • Effectors in recycling unknown
  13. 2009 Medium

    Showed in vivo that RAB3B gain-of-function enhances dopamine storage and neuroprotection, linking it to presynaptic vesicle biogenesis.

    Evidence AAV-mediated overexpression in rat substantia nigra with EM vesicle quantification, HPLC, behavior, and in vitro toxicity assays

    PMID:20007772

    Open questions at the time
    • Mechanism of vesicle number/size increase not defined
    • Effector mediating neuroprotection unknown
  14. 2011 High

    Defined a specific presynaptic role for RAB3B in endocannabinoid-dependent inhibitory long-term depression via a Rab3/RIM pathway, with behavioral consequences.

    Evidence Rab3B knockout mice, hippocampal slice electrophysiology, behavioral assays, and immunolocalization

    PMID:21844341

    Open questions at the time
    • Direct RIM1α/2α binding shown in cited prior work, not re-demonstrated here
    • Synapse-specificity mechanism unresolved
  15. 2023 Medium

    Implicated RAB3B in cytoskeletal organization and GLUT4 membrane trafficking in podocytes, regulated post-transcriptionally by a lncRNA/PTBP1 axis.

    Evidence RIP, knockdown, Western blot, and cytoskeleton/GLUT4 localization assays in podocytes

    PMID:36792603

    Open questions at the time
    • Direct effector for GLUT4 trafficking not identified
    • RAB3B nucleotide-cycle role not examined
  16. 2024 Medium

    Revealed a non-canonical RAB3B function in cancer by stabilizing DDX6 to drive lung adenocarcinoma aggressiveness.

    Evidence Co-IP, knockdown/overexpression, rescue experiments, and xenograft model

    PMID:38834947

    Open questions at the time
    • Mechanism of DDX6 stabilization undefined
    • Dependence on GTPase activity untested
  17. 2025 Medium

    Connected RAB3B to mTORC1/S6 signaling by showing it sequesters DUSP12 to sustain S6 phosphorylation and chordoma stemness.

    Evidence Co-IP, phosphorylation assays, in vivo/in vitro RAB3B ablation, and pharmacological mTORC1 inhibition

    PMID:40135815

    Open questions at the time
    • Whether RAB3B nucleotide state regulates DUSP12 binding unknown
    • Relationship to its trafficking roles unclear
  18. 2026 Medium

    Implicated RAB3B in epithelial barrier integrity through tight-junction maintenance and extracellular-vesicle internalization in amniotic cells.

    Evidence Overexpression/knockdown in hAECs with permeability, tight-junction immunofluorescence, and EV internalization assays plus PROM mouse model

    PMID:41792905

    Open questions at the time
    • Effector linking RAB3B to EV uptake unidentified
    • Newly published, not independently confirmed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RAB3B's nucleotide cycle (GEFs, GAPs) and its divergent low GTP affinity are coupled to its distinct functions in exocytosis, polarized trafficking, and non-canonical signaling remains unresolved.
  • No GEF or GAP for RAB3B identified in the corpus
  • Mechanistic link between trafficking and signaling roles unknown
  • No structural model of RAB3B-effector complexes

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005886 plasma membrane 2 GO:0031410 cytoplasmic vesicle 2 GO:0005768 endosome 1 GO:0005794 Golgi apparatus 1 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-112316 Neuronal System 1 R-HSA-162582 Signal Transduction 1 R-HSA-168256 Immune System 1
Partners
CALM1DDX6DUSP12NOC2PIGRRIM1RIM2RPH3A

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 Antisense oligonucleotide-mediated knockdown of Rab3B in rat anterior pituitary cells specifically inhibits calcium-dependent exocytosis without affecting endocytosis, placing Rab3B as a key regulator of exocytosis downstream of calcium-dependent processes. Antisense oligonucleotide knockdown introduced via whole-cell patch clamp; Ca2+-dependent exocytosis monitored electrophysiologically Nature High 8393147
1993 In human platelets, Rab3B protein is predominantly cytosolic, and thrombin-induced platelet activation leads to phosphorylation of Rab3B; phosphorylation was absent when cAMP-dependent protein kinase was stimulated (PGE1 treatment), suggesting phosphorylation is linked to secretion. Subcellular fractionation; phosphorylation assay with thrombin stimulation and PGE1 inhibition Proceedings of the National Academy of Sciences of the United States of America Medium 8356066
1996 In PC12 neuroendocrine cells, Rab3B and Rab3A both target to large dense core vesicles (LDCVs) and both bind recombinant rabphilin-3A in a GTP-dependent manner; however, Rab3B (and a GTP-binding mutant Rab3B N135I) markedly stimulates Ca2+-evoked norepinephrine secretion and increases NE accumulation into LDCVs, whereas Rab3A modestly inhibits secretion, demonstrating functionally distinct roles despite shared targeting and effector binding. Stable expression in PC12 cells; immunofluorescence and membrane fractionation for targeting; GTP-dependent pull-down with recombinant rabphilin-3A; [3H]NE release assay The Journal of biological chemistry High 8636125
1997 In bovine chromaffin cells, Rab3B has a much lower GTP[S] binding affinity (Kd ~2700 nM) compared to Rab3A (Kd ~15 nM) and Rab3C; Rab3B localizes distinctly to the plasma membrane rather than vesicle-like structures as seen for Rab3A and Rab3C; C-terminal truncation decreases GTP[S] binding affinity for all three isoforms. GTP[S] binding assays; C-terminal truncation/swap mutagenesis; immunofluorescence subcellular localization The Biochemical journal Medium 9164844
1998 Antisense knockdown of Rab3B in pituitary cells inhibits both basal and GnRH-induced gonadotrophin release without affecting intracellular gonadotrophin content or Ca2+ transients, placing Rab3B function downstream of cytosolic Ca2+ elevation in GnRH-regulated exocytosis from gonadotrophs. Antisense oligonucleotide knockdown; radioimmunoassay for hormone release; Ca2+ imaging; comparison of Rab3B-positive vs Rab3B-negative cells The Journal of endocrinology Medium 9659290
1999 Immunoelectron microscopy demonstrates co-localization of Rab3B with oxytocin within the same secretory granules of large luteal cells in the sheep corpus luteum, implicating Rab3B in luteal hormone exocytosis. Electron microscopic immunocytochemistry (dual immunogold labeling) The Anatomical record Low 9972806
2000 Stable expression of Rab3B (but not Rab3A or the GTP-binding mutant Rab3B N135I) in PC12 cells reorganizes F-actin into filopodia and redistributes the junction-associated protein ZO-1; this effect on ZO-1 is abolished by PI3-kinase inhibitors, whereas Rab3B-dependent norepinephrine secretion is PI3-kinase-independent, indicating Rab3B regulates junctional protein targeting and secretion by distinct mechanisms involving PI3-kinase signaling. Stable expression of rab3B, rab3A, and GTP-binding mutant in PC12 cells; immunofluorescence for ZO-1 and F-actin; PI3-kinase inhibitor experiments; [3H]NE secretion assay Experimental cell research Medium 10854049
2001 In human platelets, the majority of Rab3B is localized to the particulate (membrane) fraction; RabGDI-alpha pulls Rab3B from the particulate fraction; GST-Rab3B pull-down and reverse Sepharose-CaM bead experiments demonstrate a Ca2+-dependent but guanine-nucleotide-status-independent interaction between Rab3B and calmodulin. Subcellular fractionation; GST-RabGDI-alpha pull-down; GST-Rab3B pull-down of calmodulin from platelet cytosol; Sepharose-CaM bead pull-down; EGTA controls Biochemical and biophysical research communications Medium 11741295
2002 GTP-bound Rab3B directly interacts with the cytoplasmic domain of the polymeric immunoglobulin receptor (pIgR) in MDCK epithelial cells; binding of dIgA to pIgR dissociates this interaction (requiring dIgA-mediated signaling, Arg657 in pIgR cytoplasmic domain, and possibly GTP hydrolysis by rab3b); overexpression of GTP-locked rab3b inhibits dIgA-stimulated transcytosis, demonstrating that rab3b-pIgR binding controls ligand-stimulated transcytosis. Co-immunoprecipitation; direct binding assay with cytoplasmic domain of pIgR; site-directed mutagenesis (Arg657); transcytosis assay with GTP-locked rab3b overexpression; subcellular localization by immunofluorescence Developmental cell High 11832247
2003 Overexpression of dominant-negative or constitutively active Rab3B mutants in non-polarized fibroblasts specifically inhibits cell-surface transport of basolateral LDLR but not apical p75NTR or tight junctional Claudin-1, identifying Rab3B as a regulator of basolateral vesicle transport. Overexpression of Rab3B mutants in fibroblasts; cell-surface transport assay for p75NTR, LDLR, and Claudin-1 Biochemical and biophysical research communications Medium 12901864
2004 Noc2 was identified as a Rab3B effector in epithelial cells: Noc2 binds Rab3B in a GTP-dependent manner (pull-down assay); when co-expressed with GTP-bound Rab3B, Noc2 is recruited from cytosol to perinuclear membranes; Noc2 overexpression inhibits cell-surface transport of basolateral VSV-G protein. Degenerate RT-PCR; GST pull-down assay; co-expression localization by immunofluorescence; cell-surface transport assay Biochemical and biophysical research communications Medium 15003533
2006 In rat melanotrophs expressing both Rab3A and Rab3B, antisense knockdown of Rab3A (but not Rab3B) blocks Ca2+-dependent secretion; injection of GTP-bound Rab3A with intact C-terminus stimulates secretion while Rab3A T36N (GTP-binding impaired) inhibits it; injection of purified Rab3B protein is ineffective, demonstrating that Rab3A and Rab3B have non-redundant functions in regulated exocytosis in melanotrophs. Antisense oligonucleotide knockdown; patch-clamp capacitance measurements; cytosolic dialysis with recombinant proteins; in situ hybridization; immunocytochemistry American journal of physiology. Cell physiology High 16822953
2008 Gas8, a microtubule-binding protein involved in dynein motor regulation, was identified as a novel GTP-bound form-specific Rab3B-binding protein using yeast two-hybrid; Gas8 and Rab3B co-localize at the Golgi in NIH 3T3 cells; expression of the Rab3B-binding domain of Gas8 relocates Rab3B, suggesting Gas8 links Rab3B to microtubules. Yeast two-hybrid; co-localization by immunofluorescence; overexpression of Gas8 Rab3B-binding domain Archives of biochemistry and biophysics Low 18396146
2009 siRNA knockdown of Rab3b/3c in dendritic cells impairs antigen cross-presentation; Rab3b/3c-positive compartments co-localize with MHC class I molecules at perinuclear tubular structures, with internalized transferrin receptor (recycling endosomes), and with a fraction of Rab27a adjacent to phagosomes; depletion of Rab3b/3c reduces fast-phase transferrin receptor recycling, indicating Rab3b/3c-positive recycling vesicles constitute a recycling compartment involved in cross-presentation. siRNA knockdown of 57 Rab GTPases (screen); fluorescence protein-tagged β2-microglobulin tracing; co-localization immunofluorescence; transferrin recycling assay Proceedings of the National Academy of Sciences of the United States of America Medium 19717423
2009 AAV-mediated Rab3B overexpression in rat substantia nigra dopaminergic neurons increases striatal dopamine content, number and size of synaptic vesicles, and levels of presynaptic proteins; extracellular DOPAC measurement after L-DOPA injection indicates enhanced dopamine storage capacity; Rab3B overexpression protects A9 DA neurons against 6-OHDA and improves behavioral outcomes in a retrograde lesion PD model. AAV-mediated overexpression in rat SN; electron microscopy (vesicle count/size); HPLC for dopamine/DOPAC; behavioral assays; in vitro toxicity assays (6-OHDA, MG-132) in BE(2)-M17 cells Proceedings of the National Academy of Sciences of the United States of America Medium 20007772
2011 Rab3B knockout mice show impaired endocannabinoid-dependent long-term depression at inhibitory synapses (i-LTD) in CA1 hippocampus, without altering excitatory/inhibitory synaptic strength, short-term plasticity, or NMDA receptor-dependent LTP; Rab3B is highly enriched in inhibitory synapses; Rab3B KO mice display enhanced reversal learning. Rab3B interacts with RIM1α and RIM2α in a GTP-dependent manner (established by prior studies cited). This places Rab3B in a presynaptic Rab3/RIM-dependent pathway specifically at inhibitory synapses. Genetic KO; electrophysiological recordings in acute hippocampal slices; Morris water-maze and fear-conditioning behavioral assays; immunolocalization Proceedings of the National Academy of Sciences of the United States of America High 21844341
2023 The lncRNA ENST00000436340 promotes RAB3B mRNA degradation by facilitating binding of PTBP1 to RAB3B mRNA; RAB3B knockdown in podocytes causes cytoskeleton rearrangement and inhibition of GLUT4 translocation to the plasma membrane, leading to podocyte injury. RNA immunoprecipitation (RIP); gain/loss-of-function knockdown; Western blot; cytoskeleton/GLUT4 localization assays Cell death & disease Medium 36792603
2024 In lung adenocarcinoma cells, Rab3B interacts with DDX6 and enhances its protein stability; DDX6 knockdown phenocopies Rab3B depletion (reduced proliferation, colony formation, migration), and DDX6 overexpression partially rescues Rab3B-depletion phenotypes, placing DDX6 downstream of Rab3B in promoting lung adenocarcinoma aggressiveness. Co-immunoprecipitation; gain/loss-of-function overexpression and knockdown; rescue experiments; xenograft mouse model Molecular medicine (Cambridge, Mass.) Medium 38834947
2025 In chordoma, RAB3B physically interacts with the phosphatase DUSP12 and blocks DUSP12-mediated dephosphorylation of phospho-S6 at S235/236, thereby enhancing S6 phosphorylation and mTORC1/S6 signaling; RAB3B ablation reduces chordoma stemness and tumorigenicity in vivo and in vitro; mTORC1 inhibition phenocopies RAB3B overexpression effects on stemness. Co-immunoprecipitation; phosphorylation assays; in vitro and in vivo loss-of-function (RAB3B ablation); pharmacological mTORC1 inhibition; transcriptome and proteome analyses Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 40135815
2026 In human amniotic epithelial cells, RAB3B overexpression promotes cell migration, suppresses EMT, reduces epithelial permeability, and upregulates tight junction proteins; RAB3B enhances extracellular vesicle internalization, which in turn potentiates tight junction integrity; RAB3B knockdown produces opposite effects. RAB3B overexpression and siRNA knockdown in hAECs; permeability assays; immunofluorescence for tight junction proteins; extracellular vesicle isolation and internalization assay; PROM mouse model Biology of reproduction Medium 41792905

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 Inhibition of Rab3B expression attenuates Ca(2+)-dependent exocytosis in rat anterior pituitary cells. Nature 192 8393147
1993 Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. Proceedings of the National Academy of Sciences of the United States of America 93 8356066
1996 Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells. The Journal of biological chemistry 74 8636125
2022 Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy. Cell death & disease 71 35194030
2002 Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Developmental cell 68 11832247
2011 Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings of the National Academy of Sciences of the United States of America 58 21844341
2009 The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells. Proceedings of the National Academy of Sciences of the United States of America 57 19717423
2009 Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proceedings of the National Academy of Sciences of the United States of America 46 20007772
2003 Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane. Biochemical and biophysical research communications 43 12901864
2023 Long noncoding RNA ENST00000436340 promotes podocyte injury in diabetic kidney disease by facilitating the association of PTBP1 with RAB3B. Cell death & disease 31 36792603
1998 Rab3B is essential for GnRH-induced gonadotrophin release from anterior pituitary cells. The Journal of endocrinology 30 9659290
1995 Double in situ hybridization reveals overlapping neuronal populations expressing the low molecular weight GTPases Rab3a and Rab3b in Rat brain. The European journal of neuroscience 28 7620619
2006 Distinct role of Rab3A and Rab3B in secretory activity of rat melanotrophs. American journal of physiology. Cell physiology 26 16822953
2022 Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells. BMC cancer 20 35277124
2010 In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets. The Journal of endocrinology 20 20807725
2009 Rab3B immunoexpression in human pituitary adenomas. Applied immunohistochemistry & molecular morphology : AIMM 15 19384079
2005 Significance of immunohistochemical expression of Rab3B and SNAP-25 in growth hormone-producing pituitary adenomas. Acta neuropathologica 14 15895198
2001 Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin. Biochemical and biophysical research communications 14 11741295
1997 Characterization of Rab3A, Rab3B and Rab3C: different biochemical properties and intracellular localization in bovine chromaffin cells. The Biochemical journal 12 9164844
2000 Rab3B regulates ZO-1 targeting and actin organization in PC12 neuroendocrine cells. Experimental cell research 11 10854049
2008 Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells. Archives of biochemistry and biophysics 10 18396146
2008 Co-transfection of EYFP-GH and ECFP-rab3B in an experimental pituitary GH3 cell: a role of rab3B in secretion of GH through porosome. Folia histochemica et cytobiologica 10 19141391
2021 Expression of Rab3b in Human Glioma: Influence on Cell Proliferation and Apoptosis. Current pharmaceutical design 9 32940170
2004 Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. Biochemical and biophysical research communications 7 15003533
2023 circ_0000337 Promotes the Progression of Cervical Cancer by miR-155-5p/RAB3B Axis. Biochemical genetics 6 37882923
2020 Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis. Frontiers in neuroscience 6 32742255
2024 Rab3B Proteins: Cellular Functions, Regulatory Mechanisms, and Potential as a Cancer Therapy Target. Cell biochemistry and biophysics 5 39320613
1999 Co-localization of Rab3B and oxytocin to electron dense granules of the sheep corpus luteum during the estrous cycle. The Anatomical record 5 9972806
2024 Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness. Molecular medicine (Cambridge, Mass.) 4 38834947
2025 RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1-Targeted Therapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 3 40135815
2026 RAB3B regulates vesicle uptake and tight junction integrity in amniotic epithelial cells and is downregulated in premature rupture of membranes. Biology of reproduction 0 41792905
2026 The hsa_circ_0070354/miR-4322/RAB3B Axis Facilitates the Carcinogenesis and Development of Non-Small Cell Lung Cancer (NSCLC). Cancer medicine 0 42231617
2025 Discovery and validation of RAB3B as a diagnostic biomarker for prostate cancer with serum PSA below 10 ng/mL based on a multi-omics study. Cancer cell international 0 41419883

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