Affinage

RAB17

Ras-related protein Rab-17 · UniProt Q9H0T7

Length
212 aa
Mass
23.5 kDa
Annotated
2026-04-28
37 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB17 is an epithelial cell-enriched small GTPase that functions as a master regulator of polarized membrane trafficking, controlling basolateral-to-apical transcytosis, dendritic membrane insertion in neurons, melanosome release, and efferocytic cargo sorting. In polarized epithelial cells, RAB17 localizes to apical recycling endosomes and drives transcytotic vesicle docking and fusion at the apical surface through GTP hydrolysis-dependent mechanisms; monosumoylation of RAB17 enables selective interaction with Syntaxin 2 to mediate this fusion step (PMID:26957544, PMID:30256711). In hippocampal neurons, RAB17 is activated by the GEF Rabex-5/RABGEF1 and traffics to dendrites where it controls dendritic spine formation and surface delivery of GluK2 kainate receptors via Syntaxin-4 (PMID:23430262, PMID:24895134). RAB17 also participates in macrophage efferocytic cargo routing away from MHC class II loading compartments, promotes recycling-endosome membrane supply to antibacterial autophagosomes, and suppresses invasive migration and ferroptosis in cancer cells—functions regulated transcriptionally by ERK2 and post-translationally by sumoylation and ubiquitin-proteasome-dependent degradation (PMID:28005073, PMID:22328529, PMID:39242574).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1993 High

    The discovery of RAB17 as the first epithelial-specific Rab GTPase established that polarized cell types express dedicated trafficking regulators, raising the question of which transport steps RAB17 controls.

    Evidence Northern blot, in situ hybridization, immunofluorescence, and immunoelectron microscopy in mouse tissues and developing kidney

    PMID:8486736

    Open questions at the time
    • No functional assay performed
    • Mechanism of epithelial-specific transcriptional regulation unknown
  2. 1998 High

    Mutant-cycle analysis in polarized epithelial cells demonstrated that RAB17 specifically regulates basolateral-to-apical transcytosis and apical recycling from the apical recycling endosome, defining its core transport function.

    Evidence Dominant-negative and constitutively active RAB17 mutants in polarized Eph4 and MDCK cells with transcytosis assays for transferrin receptor, FcLR chimera, and dimeric IgA

    PMID:9490718 PMID:9624171

    Open questions at the time
    • SNARE partners mediating fusion not identified
    • Effectors unknown
    • Mechanism of cargo selection unclear
  3. 2011 High

    Extension of RAB17 function beyond epithelial transcytosis showed it acts downstream of Rab27a to control melanosome release via filopodia, revealing a broader role in polarized exocytic delivery.

    Evidence siRNA knockdown and epistasis with Rab27a in melanocytic cells, quantitative melanin assays and live imaging

    PMID:21291502

    Open questions at the time
    • Direct effector linking Rab17 to filopodia formation not identified
    • Relationship to actin regulation unclear
  4. 2012 High

    Two independent discoveries expanded RAB17 biology: it was found to control dendrite growth and spine formation in neurons (a non-epithelial context), and ERK2 was identified as a transcriptional suppressor of RAB17 that promotes tumor cell invasion, establishing RAB17 as an invasion suppressor.

    Evidence shRNA knockdown in hippocampal neurons with morphometric analysis; ERK1/2 isoform-specific knockdown with RAB17 rescue in 3D invasion assays in MDA-MB-231 cells

    PMID:22291024 PMID:22328529

    Open questions at the time
    • Transcription factor downstream of ERK2 that represses RAB17 not identified
    • How RAB17 suppresses invasion mechanistically not defined
  5. 2013 High

    Identification of Rabex-5/RABGEF1 as the GEF for RAB17 resolved how RAB17 is activated and explained its dendrite-selective localization: Rabex-5-mediated GTP loading promotes RAB17 translocation from the cell body to dendrites.

    Evidence Yeast two-hybrid with GDP-locked RAB17, in vitro GEF assay, Rabex-5 knockdown phenocopy in hippocampal neurons

    PMID:23430262

    Open questions at the time
    • GAP for RAB17 not identified
    • Structural basis of Rabex-5–RAB17 interaction unknown
  6. 2014 High

    A RAB17→Syntaxin-4→GluK2 pathway was defined in neurons, showing that RAB17 controls receptor-selective dendritic surface expression, while in parallel work RAB17 was shown to supply recycling endosome membranes to antibacterial autophagosomes.

    Evidence Surface biotinylation and shRNA/constitutively active RAB17 in hippocampal neurons; dominant-negative RAB17 and Rabex-5 knockdown in GcAV formation assays

    PMID:24895134 PMID:25052408

    Open questions at the time
    • How RAB17 distinguishes GluK2 from GluA1 cargo unknown
    • Direct membrane fusion mechanism at autophagosomes not reconstituted
  7. 2016 High

    Discovery of RAB17 monosumoylation and its requirement for selective Syntaxin 2 binding provided the first post-translational mechanism controlling RAB17 effector specificity at the apical surface; separately, RAB17 was shown to sort efferocytic cargo away from MHC class II compartments in macrophages.

    Evidence Sumoylation-deficient K68R mutant, co-IP with syntaxin family members in WIF-B cells; mass spectrometry of isolated efferosomes and antigen presentation assays in macrophages

    PMID:26957544 PMID:28005073

    Open questions at the time
    • SUMO E3 ligase for RAB17 not identified
    • Mechanism of efferosome-specific RAB17 recruitment unknown
    • Whether sumoylation regulates neuronal RAB17 functions untested
  8. 2018 High

    Systematic mutant analysis confirmed that RAB17 GTP hydrolysis is required for transcytotic vesicle delivery and that RAB17 is a general component of the transcytotic machinery for multiple apical residents, not just IgA.

    Evidence Panel of WT, GTP-locked, GDP-locked, and K68R RAB17 mutants with transcytosis and vesicle docking assays in WIF-B cells

    PMID:30256711

    Open questions at the time
    • Tethering factors and coat proteins involved not identified
    • Whether RAB17 acts at the docking or fusion step not resolved
  9. 2020 Medium

    ALS2 was shown to interact with RAB17 and regulate maturation of RAB17-positive nascent endosomes to EEA1-positive early endosomes downstream of RABGEF1, placing RAB17 in a clathrin-independent endocytic pathway regulated by Rac1.

    Evidence Yeast two-hybrid, GEF activity assay distinguishing ALS2 from RABGEF1, knockdown, Rac1 activation in HeLa cells

    PMID:31959474

    Open questions at the time
    • Cargo trafficked through the clathrin-independent RAB17 pathway not defined
    • Relevance to polarized epithelial transcytosis not tested
    • ALS2–RAB17 interaction awaits structural characterization
  10. 2024 Medium

    RAB17 was found to inhibit ferroptosis by promoting ubiquitin-proteasome-dependent degradation of transferrin receptor (TFRC), linking its recycling endosome function to iron metabolism and cancer cell survival under metabolic stress.

    Evidence Overexpression/knockdown with proteasome inhibitor rescue and ferroptosis assays in endometrial cancer cells in vitro and in vivo

    PMID:39242574

    Open questions at the time
    • E3 ubiquitin ligase mediating TFRC degradation downstream of RAB17 not identified
    • Whether this is a direct trafficking effect or indirect regulation unclear
    • Not independently replicated
  11. 2025 Medium

    RAB17 was shown to induce actin- and cholesterol-dependent lateral membrane protrusions in a GTP-dependent manner, interact with MAL2, and redirect Golgi-derived membrane traffic to protrusion tips while suppressing matrix degradation, providing a mechanism for its anti-invasive function; separately, LMO4-mediated proteasomal degradation of RAB17 was identified as a post-translational mechanism removing RAB17 in oral cancer.

    Evidence Adenoviral WT/mutant RAB17 with actin/cholesterol inhibitors and MAL2 co-IP in Clone 9 cells; LMO4 knockdown/overexpression with RAB17 rescue in oral squamous cell carcinoma and xenografts

    PMID:39813085 PMID:41213908

    Open questions at the time
    • MAL2–RAB17 interaction domain not mapped
    • Direct vs. indirect mechanism of LMO4-mediated RAB17 degradation unresolved
    • Physiological relevance of protrusion induction in vivo not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of the RAB17 GAP, the structural basis for sumoylation-dependent SNARE selectivity, the full effector repertoire of RAB17, and how cargo specificity is achieved across its diverse trafficking roles in epithelial cells, neurons, melanocytes, and macrophages.
  • No GAP identified
  • No structural model of RAB17 with effectors or SNAREs
  • Cargo selection mechanism across cell types unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0003924 GTPase activity 2
Localization
GO:0005768 endosome 4 GO:0031410 cytoplasmic vesicle 4 GO:0005886 plasma membrane 3 GO:0005856 cytoskeleton 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9609507 Protein localization 4 R-HSA-112316 Neuronal System 2 R-HSA-168256 Immune System 1 R-HSA-9612973 Autophagy 1
Partners
ALS2LMO4MAL2RAB27ARABGEF1STX2STX4

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 Rab17 is the first identified epithelial cell-specific small GTPase, expressed in kidney, liver, and intestine but absent in non-epithelial organs and fibroblasts; it is induced upon mesenchymal-to-epithelial differentiation in the developing kidney and localizes to the basolateral plasma membrane and apical tubules by immunofluorescence and immunoelectron microscopy. Northern blot, in situ hybridization, immunofluorescence, immunoelectron microscopy The Journal of cell biology High 8486736
1998 Rab17 localizes to the perinuclear recycling endosome in non-polarized BHK-21 cells and to the apical recycling endosome in polarized Eph4 epithelial cells; dominant-negative (GTP-binding defective) and constitutively active (GTPase-defective) Rab17 mutants both specifically increase basolateral-to-apical transcytosis of transferrin receptor and FcLR 5-27 chimeric receptor, and stimulate apical recycling, establishing Rab17 as a regulator of apical recycling endosome traffic. Confocal immunofluorescence, expression of GTP-binding and GTPase-defective mutants, transcytosis assays in polarized Eph4 cells The Journal of cell biology High 9490718
1998 In polarized MDCK cells co-expressing Rab17 and the polymeric immunoglobulin receptor (pIgR), Rab17 localizes to apical vesicles/tubules accessible to dimeric IgA internalized from both apical and basolateral surfaces; overexpression of Rab17 impairs basolateral-to-apical transcytosis of dimeric IgA, demonstrating a role for Rab17 in regulating transcellular traffic through apical recycling endosomes. Stable MDCK cell lines, immunofluorescence morphology, biochemical transcytosis assay with dimeric IgA The Journal of biological chemistry High 9624171
1999 In mouse enterocytes, Rab17 colocalizes with IgA primarily along the basolateral plasma membrane and in basolateral endosomes/vesicles, and also in the apical cytoplasm, supporting Rab17 involvement in IgA transcytosis through a glycolipid raft-containing compartment. Immunogold electron microscopy, colocalization analysis in intestinal explants Gastroenterology Medium 10029620
2011 Rab17 localizes to recycling endosomes and melanosomes in melanocytic cells; siRNA knockdown of Rab17 increases melanosome accumulation at the cell periphery, inhibits filopodia formation (without affecting melanosome maturation or movement), and causes intracellular melanin retention, placing Rab17 downstream of Rab27a in melanosome release via filopodia. GFP-Rab17 localization, siRNA knockdown, double knockdown epistasis with Rab27a, quantitative melanin assays, live imaging Traffic High 21291502
2012 Rab17 is specifically localized at dendritic growth cones, shafts, filopodia, and mature spines (but not axons) in mouse hippocampal neurons; shRNA knockdown of Rab17 reduces dendrite growth and branching and dramatically decreases dendritic spine number due to impaired filopodia formation, without affecting axon growth. shRNA knockdown, immunofluorescence, live imaging in mouse hippocampal neurons The Journal of biological chemistry High 22291024
2012 ERK2 (but not ERK1) suppresses expression of Rab17; knockdown of ERK2 increases Rab17 and liprin-β2 expression and inhibits invasive migration of MDA-MB-231 cells, and knockdown of Rab17 rescues invasiveness of ERK2-depleted cells, demonstrating that ERK2 drives invasion by transcriptionally suppressing Rab17. ERK1/2 siRNA, re-expression of ERK1 vs ERK2, gene expression arrays, Rab17 siRNA rescue in 3D invasion assays Journal of cell science High 22328529
2013 Rabex-5 (a Rab5-GEF) physically interacts with GDP-locked Rab17 (identified by yeast two-hybrid), acts as a GEF for Rab17, and promotes translocation of Rab17 from the cell body to dendrites; shRNA knockdown of Rabex-5 reduces dendritic Rab17 signals and inhibits dendrite morphogenesis, whereas Rab5 knockdown affects both axon and dendrite morphogenesis. Yeast two-hybrid with GDP-locked Rab17 mutant, GEF activity assay, shRNA knockdown, immunofluorescence in hippocampal neurons The Journal of biological chemistry High 23430262
2014 Rab17 knockdown reduces surface expression of the kainate receptor subunit GluK2 but not AMPA receptor subunit GluA1; Rab17 colocalizes with Syntaxin-4 in dendrites; Rab17 knockdown redistributes Syntaxin-4 from dendrites to axons; constitutively active Rab17 promotes dendritic surface expression of GluK2 by enhancing Syntaxin-4 translocation to dendrites, establishing a Rab17→Syntaxin-4→GluK2 trafficking pathway. shRNA knockdown, constitutively active Rab17 overexpression, surface biotinylation, immunofluorescence colocalization in hippocampal neurons The Journal of biological chemistry High 24895134
2014 Rab17 is recruited to Group A Streptococcus-containing autophagosome-like vacuoles (GcAVs) from recycling endosomes; dominant-negative Rab17 (N132I) reduces GcAV formation efficiency; overexpression of Rab17 increases transferrin receptor-positive GcAV content; knockdown of upstream activator Rabex-5 similarly reduces GcAV formation, establishing Rab17-mediated recycling endosome membrane supply to autophagosomes during antibacterial autophagy. Colocalization microscopy, dominant-negative/overexpression constructs, Rabex-5 knockdown, GcAV formation efficiency quantification Cellular microbiology Medium 25052408
2016 Mass spectrometry and immunofluorescence of efferosomes and phagosomes in macrophages showed that efferosomes recruit Rab17, whereas phagosomes do not; Rab17 mediates trafficking of efferocytosed cargo from the phagolysosome to recycling endosomes, bypassing the MHC class II loading compartment and preventing antigen presentation of apoptotic cell-derived antigens. Mass spectrometry of isolated vesicles, immunofluorescence colocalization, functional antigen presentation assay Cell death & disease High 28005073
2016 Rab17 undergoes monosumoylation (shifting its apparent mass from 25 kDa to 40 kDa), which requires prior prenylation; sumoylated, GTP-bound Rab17 selectively interacts with Syntaxin 2 (but not Syntaxins 3 or 4) in polarized hepatic WIF-B cells; a sumoylation-deficient K68R mutant causes redistribution of Syntaxin 2 and 5'-nucleotidase from the apical membrane to subapical puncta without affecting MRP2 distribution, implicating sumoylated Rab17 in transcytotic vesicle fusion at the apical surface. Recombinant adenovirus expression, immunoblotting, sumoylation mutant (K68R), co-immunoprecipitation with syntaxins, immunofluorescence in WIF-B cells The Journal of biological chemistry High 26957544
2018 Using polarized hepatic WIF-B cells expressing wild-type, GTP-bound (constitutively active), GDP-bound (dominant-negative), or K68R (sumoylation-deficient) Rab17, rab17 was confirmed to regulate basolateral-to-apical transcytotic vesicle docking and fusion at the apical surface; GTP hydrolysis is required for vesicle delivery; and rab17 acts as a general component of the transcytotic machinery for multiple classes of newly synthesized apical residents. Adenoviral expression of rab17 mutants in WIF-B cells, transcytosis assays, vesicle docking/fusion morphology Molecular biology of the cell High 30256711
2019 Influenza A virus HA and NA partially colocalize with Rab17-positive apical recycling endosome compartments post-TGN; dominant-negative Rab17 significantly delays HA transport to the plasma membrane; NA moves rapidly with Rab17 in a cholesterol-dependent manner; co-immunoprecipitation showed HA associates with Rab17 in lipid raft fractions, indicating Rab17 mediates apical trafficking of viral envelope proteins via lipid rafts. Confocal colocalization, dominant-negative Rab17 expression, live-cell imaging, co-immunoprecipitation, cholesterol depletion (methyl-β-cyclodextrin) Frontiers in microbiology Medium 31456775
2020 ALS2 physically interacts with Rab17 but lacks GEF activity toward it; RABGEF1 (Rabex-5) functions as the GEF for Rab17; ALS2 acts downstream of RABGEF1 and regulates maturation of Rab17-residing nascent endosomes (arising via clathrin-independent endocytosis) to EEA1-positive early endosomes; Rab17 localization to recycling endosomes is dependent on Rab11 expression; upon Rac1 activation, Rab17 and ALS2 are recruited to membrane ruffles and early endosomes. Yeast two-hybrid, GEF activity assay, knockdown experiments, immunofluorescence, Rac1 activation assay Biochemical and biophysical research communications Medium 31959474
2024 RAB17 inhibits ferroptosis in endometrial cancer cells by promoting ubiquitin-proteasome-dependent degradation of transferrin receptor (TFRC); RAB17 expression is upregulated under low-glucose conditions, and the RAB17-TFRC axis limits ferroptosis to promote cancer cell survival during glucose deprivation. Overexpression/knockdown, Western blot, ubiquitin-proteasome inhibitor treatment, in vitro and in vivo ferroptosis assays Cell death & disease Medium 39242574
2025 In hepatoma-derived Clone 9 cells, rab17 expression induces actin- and cholesterol-dependent lateral membrane protrusions in a GTP-dependent manner; rab17 selectively redistributes invadopodia proteins to protrusion tips, decreasing matrix degradation; rab17 interacts with MAL2 in a GTP-dependent manner; rab17 redirects newly synthesized membrane protein trafficking from Golgi to induced protrusions in a GTP-dependent fashion. Adenoviral expression of WT and mutant rab17, actin/cholesterol inhibitors, immunofluorescence, matrix degradation assay, co-immunoprecipitation with MAL2 Molecular biology of the cell Medium 39813085
2025 LMO4 promotes ubiquitin-proteasome-dependent degradation of RAB17 in oral squamous cell carcinoma cells; restoration of RAB17 expression reduces LMO4-driven proliferation, migration, and ferroptosis resistance, placing RAB17 downstream of LMO4 as a tumor suppressor subject to post-translational regulation. LMO4 knockdown/overexpression, RAB17 rescue experiments, proteasome inhibitor treatment, xenograft model, Western blot Cell death & disease Medium 41213908

Source papers

Stage 0 corpus · 37 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Maize DRE-binding proteins DBF1 and DBF2 are involved in rab17 regulation through the drought-responsive element in an ABA-dependent pathway. The Plant journal : for cell and molecular biology 150 12061899
1994 The maize abscisic acid-responsive protein Rab17 is located in the nucleus and interacts with nuclear localization signals. The Plant cell 137 8180497
1993 Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. The Journal of cell biology 129 8486736
1998 Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. The Journal of cell biology 116 9490718
1990 Gene sequence, developmental expression, and protein phosphorylation of RAB-17 in maize. Plant molecular biology 115 2151715
2004 Protein kinase CK2 modulates developmental functions of the abscisic acid responsive protein Rab17 from maize. Proceedings of the National Academy of Sciences of the United States of America 108 15159549
1998 Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. The Journal of biological chemistry 86 9624171
2011 The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic (Copenhagen, Denmark) 85 21291502
1997 Regulatory elements in vivo in the promoter of the abscisic acid responsive gene rab17 from maize. The Plant journal : for cell and molecular biology 82 9225468
1998 Phosphorylation mediates the nuclear targeting of the maize Rab17 protein. The Plant journal : for cell and molecular biology 81 9681011
2012 ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. Journal of cell science 66 22328529
2023 Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers. Burns & trauma 57 37605780
1991 Phosphorylation of maize RAB-17 protein by casein kinase 2. The Journal of biological chemistry 56 1939268
1999 Transcytosis of immunoglobulin A in the mouse enterocyte occurs through glycolipid raft- and rab17-containing compartments. Gastroenterology 55 10029620
2016 Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis. Cell death & disease 43 28005073
2013 Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons. The Journal of biological chemistry 42 23430262
2012 Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons. The Journal of biological chemistry 40 22291024
1991 Regulation of the maize rab17 gene promoter in transgenic heterologous systems. Plant molecular biology 37 1932688
2014 Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion. Cellular microbiology 35 25052408
2020 Knockdown of Circular RNA Hsa_circ_0000714 Can Regulate RAB17 by Sponging miR-370-3p to Reduce Paclitaxel Resistance of Ovarian Cancer Through CDK6/RB Pathway. OncoTargets and therapy 31 33380810
2019 Downregulation of Rab17 promotes cell proliferation and invasion in non-small cell lung cancer through STAT3/HIF-1α/VEGF signaling. Thoracic cancer 26 31841274
2015 Rab17 inhibits the tumourigenic properties of hepatocellular carcinomas via the Erk pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 23 25707355
2017 Rab17 mediates intermixing of phagocytosed apoptotic cells with recycling endosomes. Small GTPases 19 28471261
1994 Regulation of the rab17 gene promoter in transgenic Arabidopsis wild-type, ABA-deficient and ABA-insensitive mutants. Plant molecular biology 18 8155877
2019 Apical Trafficking Pathways of Influenza A Virus HA and NA via Rab17- and Rab23-Positive Compartments. Frontiers in microbiology 17 31456775
1997 Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse. Genomics 17 9367688
2015 Down-regulation of Rab17 promotes tumourigenic properties of hepatocellular carcinoma cells via Erk pathway. International journal of clinical and experimental pathology 13 26191189
2014 Small GTPase Rab17 regulates the surface expression of kainate receptors but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein. The Journal of biological chemistry 13 24895134
2016 The GTP-bound and Sumoylated Form of the rab17 Small Molecular Weight GTPase Selectively Binds Syntaxin 2 in Polarized Hepatic WIF-B Cells. The Journal of biological chemistry 12 26957544
2024 RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis. Cell death & disease 10 39242574
2018 Rab17 regulates apical delivery of hepatic transcytotic vesicles. Molecular biology of the cell 10 30256711
2020 ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes. Biochemical and biophysical research communications 7 31959474
2020 Analysis of carcinogenic signaling networks in endometrial cancer identifies RAB17 as a potential target. Journal of cellular physiology 6 32529729
2025 Hypoxic Neural Stem Cells Enhance Spinal Cord Repair Through HIF-1a/RAB17-Driven Extracellular Vesicle Release. Journal of extracellular vesicles 2 40660091
2025 MAL2 and rab17 selectively redistribute invadopodia proteins to laterally-induced protrusions in hepatocellular carcinoma cells. Molecular biology of the cell 1 39813085
2015 Assay of Rab17 and its guanine nucleotide exchange factor Rabex-5 in the dendrites of hippocampal neurons. Methods in molecular biology (Clifton, N.J.) 1 25800847
2025 LMO4 promotes OSCC progression by inducing RAB17 degradation and ferroptosis resistance. Cell death & disease 0 41213908