Affinage

RAB17

Ras-related protein Rab-17 · UniProt Q9H0T7

Length
212 aa
Mass
23.5 kDa
Annotated
2026-06-10
36 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB17 is an epithelial cell-specific small GTPase that controls polarized membrane trafficking through the apical recycling endosome, coupling cargo sorting to delivery at specialized membrane domains across multiple cell types (PMID:8486736, PMID:9490718). In polarized epithelia and hepatocytes it associates with the apical recycling endosome and regulates basolateral-to-apical transcytosis: GTP-binding and GTP-hydrolysis mutants alter transcytosis of transferrin receptor, FcLR chimeras, and dimeric IgA carried by the polymeric immunoglobulin receptor, and RAB17 acts at the subapical-compartment-to-apical-surface docking and fusion step (PMID:9490718, PMID:9624171, PMID:30256711). Its activity at this step is gated by post-translational modification: prenylation-dependent monosumoylation of GTP-bound RAB17 drives selective binding to Syntaxin-2 (but not Syntaxins 3 or 4), and a sumoylation-deficient K68R mutant mislocalizes Syntaxin-2 and apical residents, defining a sumoylation-dependent vesicle docking mechanism with GTP hydrolysis required for the subsequent fusion/delivery step (PMID:26957544, PMID:30256711). The same recycling-endosome machinery is redeployed in other contexts: RAB17 directs melanosome trafficking and filopodia formation downstream of RAB27a in melanocytes (PMID:21291502), mediates dendrite-specific membrane trafficking in hippocampal neurons—including dendritic targeting of Syntaxin-4 to control kainate receptor (GluK2) surface expression and dendrite/spine development (PMID:22291024, PMID:24895134)—and supplies recycling-endosome membrane to autophagosome-like vacuoles during antibacterial autophagy (PMID:25052408). In macrophages, RAB17 is recruited to efferosomes and sorts efferocytosed cargo away from the MHC class II loading compartment, preventing presentation of apoptotic-cell antigens (PMID:28005073, PMID:28471261). RAB17 activity is controlled upstream by the GEF Rabex-5/RABGEF1, which also drives its translocation to dendrites, with ALS2 acting downstream of RABGEF1 to regulate maturation of RAB17-residing nascent endosomes and RAB11 required for recycling-endosome localization (PMID:23430262, PMID:31959474). RAB17 is additionally regulated at the protein level by ubiquitin-proteasome-dependent degradation promoted by LMO4, and its transcription is suppressed by ERK2; loss of RAB17 promotes invasive migration and, via proteasome-dependent suppression of transferrin receptor (TFRC), attenuates ferroptosis to support cancer cell survival (PMID:22328529, PMID:39242574, PMID:41213908).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1993 Medium

    Established RAB17 as an epithelial-restricted GTPase whose expression and basolateral/apical-tubule localization implicated it in transcellular transport, defining the cell type and compartment in which to look for function.

    Evidence Northern blot, in situ hybridization, and immunoelectron microscopy on differentiating mouse kidney

    PMID:8486736

    Open questions at the time
    • No direct transport assay
    • GTPase cycle and effectors unidentified
  2. 1998 High

    Defined RAB17 as a functional regulator of the apical recycling endosome by showing GTPase-cycle mutants and overexpression bidirectionally alter basolateral-to-apical transcytosis and apical recycling of model cargoes.

    Evidence GTPase mutant expression, transcytosis and recycling assays, and confocal colocalization in polarized Eph4 and MDCK cells with IgA/pIgR

    PMID:9490718 PMID:9624171

    Open questions at the time
    • Effectors mediating docking/fusion not identified
    • Step within the pathway (sorting vs docking vs fusion) not yet resolved
  3. 1999 Medium

    Confirmed the epithelial transcytosis role in vivo by localizing RAB17 with IgA in basolateral endosomes of intestinal enterocytes.

    Evidence Immunogold electron microscopy on mouse small intestinal explants

    PMID:10029620

    Open questions at the time
    • Correlative localization only, no in vivo perturbation
  4. 2011 Medium

    Extended RAB17 function beyond transcytosis by placing it downstream of RAB27a in melanosome release and filopodia formation, indicating a conserved recycling-endosome role in peripheral cargo delivery.

    Evidence GFP-RAB17 imaging, siRNA single/double knockdown with RAB27a, melanin and filopodia quantification in melanoma cells

    PMID:21291502

    Open questions at the time
    • Molecular link to RAB27a pathway not defined
    • Effectors in melanocytes unknown
  5. 2012 Medium

    Revealed a neuronal role: RAB17 is dendrite-restricted and required for dendrite growth, branching, and spine formation, generalizing its trafficking function to polarized membrane delivery in neurons.

    Evidence shRNA knockdown, immunofluorescence, and morphometry in mouse hippocampal neurons

    PMID:22291024

    Open questions at the time
    • Cargoes delivered to dendrites not yet identified
    • Upstream activation unknown
  6. 2012 Medium

    Positioned RAB17 as a transcriptionally controlled brake on invasion, showing ERK2 suppresses RAB17 expression and RAB17 loss restores invasive migration.

    Evidence ERK2 and RAB17 siRNA knockdown, gene expression arrays, and 3D invasion assays in MDA-MB-231 cells

    PMID:22328529

    Open questions at the time
    • Trafficking mechanism linking RAB17 to invasion not defined
    • Direct vs indirect ERK2 regulation unresolved
  7. 2013 Medium

    Identified Rabex-5/RABGEF1 as the upstream GEF for RAB17 and showed it drives RAB17 translocation to dendrites, providing the activation step for dendritogenesis.

    Evidence Yeast two-hybrid with GDP-locked RAB17, shRNA knockdown, and live imaging in mouse hippocampal neurons

    PMID:23430262

    Open questions at the time
    • Direct GEF catalysis not biochemically reconstituted in this study
    • GAP for RAB17 unknown
  8. 2014 Medium

    Defined a molecular cargo mechanism in neurons: RAB17 traffics Syntaxin-4 to dendrites to selectively control kainate (GluK2) but not AMPA receptor surface expression.

    Evidence shRNA knockdown, constitutively active RAB17 overexpression, surface biotinylation, and colocalization in rat hippocampal neurons

    PMID:24895134

    Open questions at the time
    • Whether RAB17-Syntaxin-4 interaction is direct not shown
    • Selectivity basis for KAR vs AMPA cargo unclear
  9. 2014 Medium

    Demonstrated RAB17 supplies recycling-endosome membrane to autophagosome-like vacuoles during antibacterial autophagy, linking RAB17 trafficking to host defense.

    Evidence Dominant-negative and overexpression, siRNA and Rabex-5 knockdown in GAS-infected cells

    PMID:25052408

    Open questions at the time
    • Effectors at the autophagosome not identified
    • Generalizability to other pathogens untested
  10. 2016 Medium

    Established RAB17 as an immune cargo-sorting factor that diverts efferocytosed material away from the MHC class II compartment via recycling endosomes, preventing apoptotic-cell antigen presentation.

    Evidence Efferosome mass spectrometry, imaging versus phagosomes, and antigen presentation assays in macrophages

    PMID:28005073

    Open questions at the time
    • Sorting signal on cargo not defined
    • Effectors mediating diversion unknown
  11. 2016 High

    Uncovered the post-translational switch controlling RAB17 docking: prenylation-dependent monosumoylation of GTP-bound RAB17 confers selective Syntaxin-2 binding required for correct apical residence of cargo.

    Evidence Sumoylation immunoblotting, co-IP, and K68R/nucleotide-state mutant analysis in polarized WIF-B hepatocytes

    PMID:26957544

    Open questions at the time
    • SUMO E3 ligase and desumoylase not identified
    • Whether sumoylation cycles with the GTPase cycle unresolved
  12. 2018 High

    Dissected the transport step, showing GTP-bound sumoylated RAB17 mediates apical vesicle docking while GTP hydrolysis drives delivery, generalizing across three classes of apical residents.

    Evidence Wild-type, dominant-active, dominant-negative, and sumoylation-deficient RAB17 with transcytosis assays in polarized WIF-B hepatocytes

    PMID:30256711

    Open questions at the time
    • Identity of the GAP triggering hydrolysis unknown
    • Tethering complex bridging vesicle and membrane not defined
  13. 2019 Medium

    Showed RAB17 mediates cholesterol/lipid-raft-dependent apical transport of influenza envelope proteins, indicating the apical pathway is hijacked by viruses.

    Evidence Confocal imaging, dominant-negative RAB17, lipid-raft co-IP, and methyl-β-cyclodextrin treatment in stable cell lines

    PMID:31456775

    Open questions at the time
    • Whether HA/NA bind RAB17 directly or via raft scaffolds unresolved
    • Role in viral assembly versus surface delivery not separated
  14. 2020 Medium

    Clarified the upstream regulatory hierarchy: RABGEF1 (not ALS2) is the RAB17 GEF, ALS2 acts downstream to mature RAB17 endosomes to EEA1-positive early endosomes, and RAB11 is needed for recycling-endosome localization, with Rac1-driven co-recruitment to ruffles.

    Evidence Co-IP, GEF activity assays, shRNA knockdown, and Rac1 activation with immunofluorescence

    PMID:31959474

    Open questions at the time
    • Mechanism of ALS2-dependent maturation not detailed
    • How RAB11 controls RAB17 targeting unresolved
  15. 2024 Medium

    Linked RAB17 to cancer metabolism by showing it attenuates ferroptosis through proteasome-dependent suppression of transferrin receptor (TFRC), promoting survival under low glucose.

    Evidence RAB17 overexpression/knockdown, TFRC western blot, proteasome inhibitor assays, and xenografts in endometrial cancer cells

    PMID:39242574

    Open questions at the time
    • How RAB17 routes TFRC to degradation mechanistically unclear
    • Whether classical trafficking activity underlies this effect untested
  16. 2025 Medium

    Identified LMO4 as a post-translational negative regulator that promotes ubiquitin-proteasome degradation of RAB17, controlling proliferation, migration, and ferroptosis resistance in oral squamous cell carcinoma.

    Evidence LMO4 overexpression/knockdown, RAB17 rescue, proteasome inhibitor assays, and xenografts

    PMID:41213908

    Open questions at the time
    • Direct E3 ligase recruited by LMO4 not identified
    • Ubiquitination sites on RAB17 unmapped
  17. 2025 Medium

    Demonstrated RAB17 can drive formation of actin/cholesterol-dependent membrane protrusions, redirect Golgi-derived cargo and invadopodia proteins, and reduce matrix degradation, via GTP-dependent interaction with MAL2.

    Evidence Wild-type/mutant expression, co-IP, actin/cholesterol depletion, matrix degradation, and trafficking assays in Clone 9 cells

    PMID:39813085

    Open questions at the time
    • Whether MAL2 is the physiological effector in other cell types untested
    • Relationship between protrusion role and transcytosis role unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • The GAP that terminates RAB17 signaling, the SUMO ligase/desumoylase acting on K68, and the full tethering machinery linking RAB17-Syntaxin-2 docking to membrane fusion remain unidentified.
  • No RAB17 GAP identified
  • SUMO E3 ligase/desumoylase for RAB17 unknown
  • Structure of RAB17 effector complexes undetermined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 5 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005768 endosome 4 GO:0005886 plasma membrane 3 GO:0031410 cytoplasmic vesicle 3
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9609507 Protein localization 3 R-HSA-168256 Immune System 2 R-HSA-9612973 Autophagy 1
Partners
ALS2LMO4MAL2RAB11RABGEF1STX2STX4

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 RAB17 is a small GTPase specific to epithelial cells, induced upon mesenchymal-to-epithelial differentiation during kidney development, and localizes to the basolateral plasma membrane and apical tubules, suggesting a role in transcellular transport. Northern blot, in situ hybridization, immunofluorescence, immunoelectron microscopy on mouse kidney sections The Journal of cell biology Medium 8486736
1998 RAB17 associates with the apical recycling endosome in polarized Eph4 epithelial cells and with the perinuclear recycling endosome in non-polarized BHK-21 cells; dominant-negative (GTP-binding deficient) and constitutively active (hydrolysis-deficient) RAB17 mutants specifically increased basolateral-to-apical transcytosis of transferrin receptor and FcLR chimeric receptor, and stimulated apical recycling, establishing RAB17 as a regulator of traffic through the apical recycling endosome. Confocal immunofluorescence microscopy, expression of GTPase mutants, transcytosis assays in polarized Eph4 cells The Journal of cell biology High 9490718
1998 RAB17 localizes to small vesicles and tubules in the apical region of MDCK cells, colocalizes with dimeric IgA internalized via the polymeric immunoglobulin receptor (pIgR) from both apical and basolateral surfaces, and overexpression of RAB17 impairs basolateral-to-apical transcytosis of dimeric IgA, providing morphological and functional evidence for RAB17 in regulating transcellular traffic through apical recycling endosomes. Stable MDCK cell lines expressing wild-type or mutant RAB17 and pIgR, immunofluorescence/electron microscopy, IgA transcytosis assay The Journal of biological chemistry High 9624171
1999 RAB17 colocalizes with IgA along the basolateral plasma membrane and in basolateral endosomes/vesicles of mouse enterocytes, supporting its involvement in IgA transcytosis through raft-containing compartments in vivo. Immunogold electron microscopy on mouse small intestinal explants Gastroenterology Medium 10029620
2011 RAB17 localizes to recycling endosomes and melanosomes in melanocytic cells; siRNA knockdown of RAB17 causes accumulation of melanosomes at the cell periphery and increased melanin retention inside cells, inhibits filopodia formation, and acts downstream of RAB27a in the melanosome release pathway. GFP-RAB17 live imaging, siRNA knockdown, double knockdown with RAB27a, melanin quantification, filopodia counting in melanoma cells Traffic Medium 21291502
2012 RAB17 localizes specifically to dendritic growth cones, shafts, filopodia, and mature spines (but not axons) in mouse hippocampal neurons; shRNA-mediated knockdown reduces dendrite growth, branching, and dendritic spine number, identifying RAB17 as a regulator of dendrite-specific membrane trafficking and postsynaptic development. shRNA knockdown, immunofluorescence, morphometric analysis in mouse hippocampal neurons The Journal of biological chemistry Medium 22291024
2012 ERK2 (but not ERK1) suppresses RAB17 gene expression, and knockdown of RAB17 restores invasive migration in ERK2-depleted MDA-MB-231 cancer cells, placing RAB17 downstream of ERK2 as an inhibitor of invasive migration in 3D matrices. ERK2 siRNA knockdown, gene expression arrays, RAB17 siRNA knockdown in ERK2-depleted cells, 3D invasion assays Journal of cell science Medium 22328529
2013 Rabex-5 (a Rab5-GEF) interacts with a GDP-locked RAB17 mutant and promotes translocation of RAB17 from the cell body to the dendrites of developing mouse hippocampal neurons; shRNA knockdown of Rabex-5 inhibits both axon and dendrite morphogenesis, while RAB17 knockdown affects dendrite morphogenesis alone, indicating Rabex-5 acts upstream of RAB17 as its GEF to regulate dendritogenesis. Yeast two-hybrid screen with GDP-locked RAB17 as bait, shRNA knockdown, live-cell fluorescence imaging in mouse hippocampal neurons The Journal of biological chemistry Medium 23430262
2014 RAB17 knockdown reduces surface expression of the kainate receptor subunit GluK2, but not AMPA receptor subunit GluA1; RAB17 colocalizes with Syntaxin-4 in dendrites, and RAB17 knockdown causes Syntaxin-4 redistribution from dendrites to axons; constitutively active RAB17 promotes dendritic GluK2 surface expression by enhancing Syntaxin-4 translocation to dendrites, indicating RAB17 selectively regulates KAR surface expression by mediating dendritic trafficking of Syntaxin-4. shRNA knockdown, surface biotinylation, immunofluorescence, overexpression of constitutively active RAB17 in rat hippocampal neurons The Journal of biological chemistry Medium 24895134
2014 RAB17-mediated recycling endosomes supply membrane to Group A Streptococcus-containing autophagosome-like vacuoles (GcAVs); dominant-negative RAB17 (N132I) reduces GcAV formation efficiency, while RAB17 overexpression increases TfR-positive GcAV content; knockdown of upstream activator Rabex-5 similarly reduces GcAV formation, establishing RAB17 as a mediator of recycling endosome-to-autophagosome membrane supply during antibacterial autophagy. Colocalization analysis, dominant-negative overexpression, siRNA knockdown, Rabex-5 knockdown in GAS-infected cells Cellular microbiology Medium 25052408
2016 Mass spectrometry of efferosomes in macrophages showed that they lack antigen presentation proteins and instead recruit RAB17; RAB17-dependent sorting diverts efferocytosed cargo away from the MHC class II loading compartment via the recycling endosome pathway, preventing presentation of apoptotic cell-derived antigens. Mass spectrometry, immunofluorescence microscopy of efferosomes vs phagosomes, functional antigen presentation assays in macrophages Cell death & disease Medium 28005073
2016 RAB17 undergoes monosumoylation (shifting from 25 kDa to 40 kDa), and prenylation is required for sumoylation; the GTP-bound, sumoylated form of RAB17 selectively binds Syntaxin-2 (but not Syntaxins 3 or 4) in polarized hepatic WIF-B cells; a sumoylation-deficient K68R mutant redistributes Syntaxin-2 and 5'-nucleotidase from the apical membrane to subapical puncta, indicating sumoylation-dependent interactions with Syntaxin-2 mediate apical vesicle fusion. Recombinant adenovirus expression, immunoblotting, co-immunoprecipitation, mutant analysis (K68R, GTP/GDP-bound forms) in polarized WIF-B cells The Journal of biological chemistry High 26957544
2017 RAB17 is rapidly recruited to efferosomes after apoptotic cell uptake; efferosomes migrate to the cell center where they undergo RAB17-dependent vesiculation, and resulting vesicles traffic in a RAB17-dependent manner to the cell periphery, transferring cargo to recycling endosomes to prevent further phagolysosome maturation. Live-cell imaging, immunofluorescence microscopy, RAB17 functional perturbation in macrophages Small GTPases Medium 28471261
2018 RAB17 regulates basolateral-to-apical transcytotic vesicle docking and fusion at the apical surface in polarized hepatic WIF-B cells; GTP-bound and sumoylated RAB17 are required for apical vesicle docking; GTP hydrolysis is required for vesicle delivery; transcytosis is impaired at the subapical compartment-to-apical surface step; this function applies broadly to three classes of newly synthesized apical residents. Exogenous expression of wild-type, dominant active, dominant negative, and sumoylation-deficient RAB17 in polarized WIF-B hepatocytes; transcytosis assays; immunofluorescence Molecular biology of the cell High 30256711
2019 Influenza A virus HA and NA colocalize with RAB17-positive compartments after synthesis; dominant-negative RAB17 significantly delays HA transport to the plasma membrane; HA associates with RAB17 in lipid raft fractions by co-immunoprecipitation; cholesterol depletion by methyl-β-cyclodextrin abolishes RAB17-associated NA movement, indicating RAB17 mediates cholesterol/lipid raft-dependent apical transport of viral envelope proteins. Confocal microscopy in stable AcGFP-Rab cell lines, dominant-negative RAB17 expression, co-immunoprecipitation from lipid raft fractions, methyl-β-cyclodextrin treatment, live-cell imaging Frontiers in microbiology Medium 31456775
2020 ALS2 interacts physically with RAB17 but lacks GEF activity for RAB17 (RABGEF1/Rabex-5 is the actual Rab17-GEF); ALS2 acts downstream of RABGEF1 and regulates maturation of Rab17-residing nascent endosomes to EEA1-positive early endosomes; upon Rac1 activation, RAB17 and ALS2 are co-recruited to membrane ruffles and early endosomes in a Rab5-activity-independent manner; RAB17 localization to recycling endosomes depends on RAB11 expression. Co-immunoprecipitation, GEF activity assays, shRNA knockdown, Rac1 activation, immunofluorescence in cell lines Biochemical and biophysical research communications Medium 31959474
2024 RAB17 attenuates ferroptosis in endometrial cancer cells by inhibiting transferrin receptor (TFRC) protein expression through a ubiquitin proteasome-dependent mechanism; RAB17 expression is increased under low-glucose conditions and limits ferroptosis to promote cancer cell survival via the RAB17-TFRC axis. RAB17 overexpression/knockdown, western blot for TFRC, proteasome inhibitor assays, in vitro and in vivo xenograft models Cell death & disease Medium 39242574
2025 LMO4 promotes ubiquitin-proteasome-dependent degradation of RAB17 in oral squamous cell carcinoma cells; restoration of RAB17 expression reduces proliferation, migration, and ferroptosis resistance conferred by LMO4, identifying LMO4 as an upstream E3 ligase-recruiting factor that negatively regulates RAB17 protein levels post-translationally. LMO4 overexpression/knockdown, RAB17 rescue expression, western blot, proteasome inhibitor assays, xenograft mouse model Cell death & disease Medium 41213908
2025 RAB17 expression in hepatoma-derived Clone 9 cells induces actin- and cholesterol-dependent lateral membrane protrusions in a GTP-dependent manner; RAB17 selectively redistributes invadopodia proteins to protrusion tips and reduces matrix degradation; RAB17 interacts with MAL2 in a GTP-dependent manner; RAB17 redirects newly synthesized membrane proteins from the Golgi to induced protrusions in a GTP-dependent manner. Exogenous expression of wild-type and GTPase mutants, co-immunoprecipitation, actin/cholesterol depletion, matrix degradation assays, live trafficking assays in Clone 9 cells Molecular biology of the cell Medium 39813085

Source papers

Stage 0 corpus · 36 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Maize DRE-binding proteins DBF1 and DBF2 are involved in rab17 regulation through the drought-responsive element in an ABA-dependent pathway. The Plant journal : for cell and molecular biology 150 12061899
1994 The maize abscisic acid-responsive protein Rab17 is located in the nucleus and interacts with nuclear localization signals. The Plant cell 137 8180497
1993 Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. The Journal of cell biology 129 8486736
1998 Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. The Journal of cell biology 116 9490718
1990 Gene sequence, developmental expression, and protein phosphorylation of RAB-17 in maize. Plant molecular biology 115 2151715
2004 Protein kinase CK2 modulates developmental functions of the abscisic acid responsive protein Rab17 from maize. Proceedings of the National Academy of Sciences of the United States of America 108 15159549
1998 Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. The Journal of biological chemistry 86 9624171
2011 The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic (Copenhagen, Denmark) 85 21291502
1998 Phosphorylation mediates the nuclear targeting of the maize Rab17 protein. The Plant journal : for cell and molecular biology 82 9681011
1997 Regulatory elements in vivo in the promoter of the abscisic acid responsive gene rab17 from maize. The Plant journal : for cell and molecular biology 82 9225468
2012 ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. Journal of cell science 66 22328529
2023 Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers. Burns & trauma 62 37605780
1991 Phosphorylation of maize RAB-17 protein by casein kinase 2. The Journal of biological chemistry 56 1939268
1999 Transcytosis of immunoglobulin A in the mouse enterocyte occurs through glycolipid raft- and rab17-containing compartments. Gastroenterology 55 10029620
2016 Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis. Cell death & disease 44 28005073
2013 Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons. The Journal of biological chemistry 42 23430262
2012 Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons. The Journal of biological chemistry 40 22291024
1991 Regulation of the maize rab17 gene promoter in transgenic heterologous systems. Plant molecular biology 37 1932688
2014 Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion. Cellular microbiology 35 25052408
2020 Knockdown of Circular RNA Hsa_circ_0000714 Can Regulate RAB17 by Sponging miR-370-3p to Reduce Paclitaxel Resistance of Ovarian Cancer Through CDK6/RB Pathway. OncoTargets and therapy 31 33380810
2019 Downregulation of Rab17 promotes cell proliferation and invasion in non-small cell lung cancer through STAT3/HIF-1α/VEGF signaling. Thoracic cancer 26 31841274
2015 Rab17 inhibits the tumourigenic properties of hepatocellular carcinomas via the Erk pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 23 25707355
2017 Rab17 mediates intermixing of phagocytosed apoptotic cells with recycling endosomes. Small GTPases 20 28471261
2019 Apical Trafficking Pathways of Influenza A Virus HA and NA via Rab17- and Rab23-Positive Compartments. Frontiers in microbiology 17 31456775
1997 Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse. Genomics 17 9367688
2015 Down-regulation of Rab17 promotes tumourigenic properties of hepatocellular carcinoma cells via Erk pathway. International journal of clinical and experimental pathology 13 26191189
2014 Small GTPase Rab17 regulates the surface expression of kainate receptors but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein. The Journal of biological chemistry 13 24895134
2016 The GTP-bound and Sumoylated Form of the rab17 Small Molecular Weight GTPase Selectively Binds Syntaxin 2 in Polarized Hepatic WIF-B Cells. The Journal of biological chemistry 12 26957544
2024 RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis. Cell death & disease 11 39242574
2018 Rab17 regulates apical delivery of hepatic transcytotic vesicles. Molecular biology of the cell 10 30256711
2020 ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes. Biochemical and biophysical research communications 7 31959474
2020 Analysis of carcinogenic signaling networks in endometrial cancer identifies RAB17 as a potential target. Journal of cellular physiology 6 32529729
2025 Hypoxic Neural Stem Cells Enhance Spinal Cord Repair Through HIF-1a/RAB17-Driven Extracellular Vesicle Release. Journal of extracellular vesicles 3 40660091
2025 MAL2 and rab17 selectively redistribute invadopodia proteins to laterally-induced protrusions in hepatocellular carcinoma cells. Molecular biology of the cell 1 39813085
2015 Assay of Rab17 and its guanine nucleotide exchange factor Rabex-5 in the dendrites of hippocampal neurons. Methods in molecular biology (Clifton, N.J.) 1 25800847
2025 LMO4 promotes OSCC progression by inducing RAB17 degradation and ferroptosis resistance. Cell death & disease 0 41213908

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