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Showing EPRS1 — QARS is a alias.

EPRS1

Bifunctional glutamate/proline--tRNA ligase · UniProt P07814

Length
1512 aa
Mass
170.6 kDa
Annotated
2026-06-09
100 papers in source corpus 9 papers cited in narrative 9 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EPRS1 is a bifunctional aminoacyl-tRNA synthetase encoded by a single locus on chromosome 1q, carrying both class I glutamyl-tRNA synthetase and class II prolyl-tRNA synthetase activities on one polypeptide separated by a noncatalytic linker implicated in multi-tRNA synthetase complex (MSC) organization (PMID:8188258). Within the MSC, EPRS1 assembles through the DRS–AIMP2–EPRS ternary subcomplex, in which EPRS and AIMP2 heterodimerize via GST-like domains and DRS contacts AIMP2 to form a structural pivot of the larger complex (PMID:31576228). Beyond aminoacylation, EPRS1 is mobilized from the MSC by sequential phosphorylation of its linker: IFN-γ-driven Ser886 phosphorylation, followed by Ser999 phosphorylation, licenses ordered recruitment of NSAP1, ribosomal protein L13a, and GAPDH to build the heterotetrameric GAIT complex that binds eIF4G and represses translation of GAIT-element mRNAs (PMID:19647514). Ser999 phosphorylation by the mTORC1–S6K1 axis instead directs EPRS1 to SLC27A1/FATP1, promoting FATP1 plasma-membrane translocation, long-chain fatty acid uptake, and adiposity, establishing EPRS1 as a terminal mTORC1–S6K1 metabolic effector (PMID:28178239). EPRS1 protein output is itself tuned by the integrated stress response, in which eIF2α phosphorylation enables ribosomal bypass of inhibitory upstream ORFs in the 5'-leader to raise EPRS1 levels (PMID:27002157). Bi-allelic loss-of-function variants that reduce aminoacylation activity cause hypomyelinating leukodystrophy and related neurodevelopmental disorders (PMID:29576217, PMID:36411955).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1994 High

    Established the fundamental architecture of EPRS1 — that a single human gene encodes a bifunctional polypeptide bearing two mechanistically distinct synthetase activities joined by a linker.

    Evidence Genomic sequencing, exon mapping, and in situ hybridization defining gene structure and chromosomal location

    PMID:8188258

    Open questions at the time
    • Did not address how the linker mediates MSC assembly
    • No functional dissection of the two catalytic domains in vivo
  2. 2009 High

    Resolved how a housekeeping synthetase is repurposed as a translational repressor, showing that ordered linker phosphorylation drives EPRS1 release from the MSC and stepwise assembly of the GAIT complex.

    Evidence Phosphosite mutagenesis, Co-IP, mRNA-binding and in vitro translation repression assays with mass spectrometry

    PMID:19647514

    Open questions at the time
    • Kinase responsible for Ser886 not fully resolved
    • In vivo physiological consequences of GAIT silencing not established here
  3. 2016 Medium

    Showed that EPRS1 abundance is itself stress-regulated, identifying uORF-mediated translational control bypassed during the integrated stress response.

    Evidence Translation reporter assays, uORF mutagenesis, eIF2α phosphorylation induction, and EPRS immunoblot

    PMID:27002157

    Open questions at the time
    • Functional consequence of elevated EPRS1 during stress not defined
    • Single-lab result
  4. 2016 Low

    Linked EPRS1 to a cancer-cell proliferation context, implicating it in estrogen signaling in tamoxifen-resistant ER+ breast cancer.

    Evidence siRNA knockdown, proliferation assays, transcriptomic profiling and network construction

    PMID:27612429

    Open questions at the time
    • No direct molecular mechanism beyond transcriptomic association
    • Selectivity for ER+ versus ER- cells not mechanistically explained
  5. 2017 High

    Identified EPRS1 as a terminal effector of mTORC1–S6K1 metabolic signaling through phospho-Ser999-dependent control of fatty acid uptake.

    Evidence Phospho-deficient/mimetic knock-in mice, genetic epistasis rescue in S6K1-KO, FATP1 binding and fatty acid uptake assays

    PMID:28178239

    Open questions at the time
    • How Ser999 phosphorylation is partitioned between GAIT and FATP1 functions unclear
    • Structural basis of EPRS1-FATP1 interaction not defined
  6. 2018 Medium

    Connected EPRS1 to human disease, establishing reduced aminoacylation activity rather than disrupted MSC assembly as the mechanism of hypomyelinating leukodystrophy.

    Evidence Affinity purification-mass spectrometry, immunoblot, and aminoacylation assays in patient cells and recombinant protein

    PMID:29576217

    Open questions at the time
    • Why reduced aminoacylation preferentially affects myelination not explained
    • Single-study/single-lab evidence
  7. 2019 High

    Provided the structural basis for EPRS1's place in the MSC, defining the DRS-AIMP2-EPRS subcomplex as a GST-mediated assembly pivot.

    Evidence X-ray crystallography of the ternary subcomplex with structural mutagenesis of AIMP2 Ser156

    PMID:31576228

    Open questions at the time
    • Does not capture full MSC architecture
    • Linker/catalytic domains not resolved in this structure
  8. 2021 Medium

    Proposed a non-canonical signaling role in gastric cancer via direct binding to SCYL2 and activation of WNT/β-catenin signaling.

    Evidence Reciprocal Co-IP, EPRS knockdown with β-catenin readouts, and cell- and patient-derived xenograft models

    PMID:33740160

    Open questions at the time
    • Mechanism by which EPRS-SCYL2 binding activates GSK-3β/β-catenin not resolved
    • Single-lab finding
  9. 2022 Medium

    Extended the disease spectrum and confirmed loss of catalytic activity as the pathogenic mechanism in a distinct neurodevelopmental presentation.

    Evidence In vitro aminoacylation assays with recombinant compound heterozygous mutant proteins

    PMID:36411955

    Open questions at the time
    • Single-patient report
    • Genotype-phenotype correlation across the disorder not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How EPRS1 partitions between its canonical aminoacylation role and its multiple moonlighting functions (GAIT repression, FATP1-mediated metabolism, WNT signaling) within a single cell remains unresolved.
  • No integrated model coordinating MSC retention versus phospho-dependent release
  • Tissue-specific balance of moonlighting activities undefined
  • Structural basis of non-canonical partner interactions unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016874 ligase activity 3 GO:0140098 catalytic activity, acting on RNA 3 GO:0003723 RNA binding 1 GO:0045182 translation regulator activity 1
Localization
GO:0005829 cytosol 2 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-1643685 Disease 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-8953854 Metabolism of RNA 2
Partners
AIMP2DARSEIF4G1GAPDHNSAP1RPL13ASCYL2SLC27A1
Complex memberships
DRS-AIMP2-EPRS subcomplexGAIT complexmulti-tRNA synthetase complex (MSC)

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 EPRS is phosphorylated at Ser999 by the mTORC1-S6K1 axis, which induces its release from the aminoacyl tRNA multisynthetase complex (MSC). Released phospho-EPRS binds SLC27A1/FATP1, inducing FATP1 translocation to the plasma membrane and long-chain fatty acid uptake. Knock-in mice bearing phospho-deficient S999A mutation showed reduced adiposity and increased lifespan similar to S6K1-deficient mice, and phospho-mimetic S999D substitution in S6K1-deficient mice normalized body mass, establishing EPRS as a terminal mTORC1-S6K1 effector for metabolic phenotypes. Phospho-deficient and phospho-mimetic knock-in mouse models, interaction screening (co-immunoprecipitation/pulldown), fatty acid uptake assays, genetic epistasis (S999D rescue in S6K1-KO mice) Nature High 28178239
2009 IFN-γ induces sequential phosphorylation of EPRS at Ser886 and Ser999 in the noncatalytic linker region. Ser886 phosphorylation is required for NSAP1 interaction (blocking mRNA binding), followed by binding of ribosomal protein L13a and GAPDH (restoring mRNA binding). Ser999 phosphorylation then directs formation of the functional heterotetrameric GAIT complex that binds eIF4G and represses translation of GAIT-element-containing mRNAs. Both phosphorylations are essential for EPRS release from the multisynthetase complex. Phosphorylation-site mutagenesis, co-immunoprecipitation, mRNA-binding assays, in vitro translation repression assays, mass spectrometry Molecular cell High 19647514
1994 The human EPRS gene encodes a bifunctional polypeptide containing both glutamyl-tRNA synthetase (class I) and prolyl-tRNA synthetase (class II) activities on a single polypeptide chain, transcribed from a single locus on chromosome 1q. The gene comprises 29 exons spanning >90 kb, with exon clusters encoding each synthetase domain separated by exons encoding a linker region implicated in the multisynthetase complex organization. Gene structure determination (genomic sequencing, exon mapping), chromosomal localization (in situ hybridization), mRNA analysis Genomics High 8188258
2018 Bi-allelic pathogenic variants in EPRS cause hypomyelinating leukodystrophy. The p.Pro1115Arg variant did not disrupt MSC assembly (as monitored by affinity purification-mass spectrometry) but reduced EPRS protein levels in fibroblasts. EPRS aminoacylation activity was reduced in lymphoblasts from one affected individual and in a purified recombinant protein model, establishing that loss of aminoacyl-tRNA synthetase activity is a disease mechanism. Affinity purification-mass spectrometry (MSC assembly), immunoblot (protein levels), enzymatic aminoacylation assay (lymphoblasts and recombinant protein) American journal of human genetics Medium 29576217
2016 Translation of the EPRS mRNA coding region is enhanced during integrated stress response via eIF2α phosphorylation. Two upstream ORFs (uORFs) with noncanonical CUG and UUG initiation codons in the EPRS 5'-leader normally dampen EPRS translation; increased eIF2α phosphorylation facilitates ribosome bypass of these inhibitory uORFs, increasing EPRS protein levels. Biochemical translation reporter assays, uORF mutagenesis, eIF2α phosphorylation induction with multiple stressors, immunoblot of EPRS protein levels The Journal of biological chemistry Medium 27002157
2019 The crystal structure of the DRS-AIMP2GST-EPRSGST ternary subcomplex was determined by X-ray crystallography, revealing that EPRSGST and AIMP2GST interact via conventional GST heterodimerization, and that DRS strongly contacts AIMP2GST via hydrogen bonds between the α7-β9 loop of DRS and the β2-α2 loop of AIMP2GST (with Ser156 of AIMP2GST essential for assembly). This subcomplex acts as a structural pivot within the multi-tRNA synthetase complex. X-ray crystallography, structural mutagenesis (Ser156 of AIMP2GST), complex assembly analysis IUCrJ High 31576228
2021 EPRS directly binds SCYL2 (as shown by immunoprecipitation) to enhance activation of the WNT/GSK-3β/β-catenin signaling pathway, leading to β-catenin nuclear accumulation and gastric cancer cell proliferation. Knockdown of EPRS reduced β-catenin signaling and tumor growth in vitro and in xenograft models. Co-immunoprecipitation (EPRS-SCYL2 interaction), EPRS knockdown with β-catenin pathway readout, cell-derived and patient-derived xenograft mouse models Gastric cancer Medium 33740160
2022 Compound heterozygous missense mutations in EPRS1 cause major defects in glutamyl- and prolyl-tRNA aminoacylation enzymatic activity, as demonstrated by in vitro aminoacylation assays with recombinant mutant proteins, establishing loss of catalytic activity as the pathogenic mechanism in a patient with psychomotor developmental delay, seizures, and deafness. In vitro aminoacylation assays with recombinant mutant EPRS1 proteins, functional characterization of two compound heterozygous missense variants Clinical genetics Medium 36411955
2016 EPRS is required for proliferation of tamoxifen-resistant ER+ breast cancer cells (but not ER- cells), and transcriptomic profiling after EPRS knockdown showed regulation of cell cycle and estrogen response gene networks, placing EPRS within an estrogen signaling pathway in ER+ breast cancer. EPRS siRNA knockdown, cell proliferation assays, transcriptomic profiling, causal gene network construction from tumor datasets Oncotarget Low 27612429

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1989 How the ear's works work. Nature 584 2677742
1999 Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nature genetics 534 10471511
2013 3D printed bionic ears. Nano letters 375 23635097
2015 Expression of trehalose-6-phosphate phosphatase in maize ears improves yield in well-watered and drought conditions. Nature biotechnology 297 26473199
2015 Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears. The Journal of neuroscience : the official journal of the Society for Neuroscience 281 25972177
2002 From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proceedings of the National Academy of Sciences of the United States of America 180 12032315
2021 Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery. Developmental cell 173 33400914
2004 Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Human molecular genetics 166 15254021
2003 Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development (Cambridge, England) 151 12642503
1998 Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). Arteriosclerosis, thrombosis, and vascular biology 142 9555857
2011 The walls have ears: the role of plant CrRLK1Ls in sensing and transducing extracellular signals. Journal of experimental botany 127 21252257
1999 Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations. The EARS Group. European journal of clinical investigation 115 10092998
2017 EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature 108 28178239
2009 Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. Molecular cell 106 19647514
1978 Behavioral, compound action potential, and single unit thresholds: relationship in normal and abnormal ears. The Journal of the Acoustical Society of America 95 711993
1992 Distortion-product emissions and auditory sensitivity in human ears with normal hearing and cochlear hearing loss. Journal of speech and hearing research 86 1447925
1999 Interaction of Fusarium graminearum and F. moniliforme in Maize Ears: Disease Progress, Fungal Biomass, and Mycotoxin Accumulation. Phytopathology 85 18944658
2013 Evolution of vertebrate mechanosensory hair cells and inner ears: toward identifying stimuli that select mutation driven altered morphologies. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 84 24281353
2015 Gene Therapy Restores Hair Cell Stereocilia Morphology in Inner Ears of Deaf Whirler Mice. Molecular therapy : the journal of the American Society of Gene Therapy 82 26307667
2014 Identification of miRNAs and their target genes in developing maize ears by combined small RNA and degradome sequencing. BMC genomics 82 24422852
2018 Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy. American journal of human genetics 78 29576217
1997 The evolution of tetrapod ears and the fossil record. Brain, behavior and evolution 78 9310195
2013 Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. Proceedings of the National Academy of Sciences of the United States of America 71 23918390
2017 Neurotrophin Gene Therapy in Deafened Ears with Cochlear Implants: Long-term Effects on Nerve Survival and Functional Measures. Journal of the Association for Research in Otolaryngology : JARO 70 28776202
2011 BARREN STALK FASTIGIATE1 is an AT-hook protein required for the formation of maize ears. The Plant cell 68 21540434
1993 Otoacoustic emissions in children with normal ears, middle ear dysfunction, and ventilating tubes. The American journal of otology 68 8424474
2013 Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears. American journal of human genetics 64 24268655
2020 Building inner ears: recent advances and future challenges for in vitro organoid systems. Cell death and differentiation 57 33318601
2019 "Ears of the Lynx" MRI Sign Is Associated with SPG11 and SPG15 Hereditary Spastic Paraplegia. AJNR. American journal of neuroradiology 57 30606727
2018 The Effortless Assessment of Risk States (EARS) Tool: An Interpersonal Approach to Mobile Sensing. JMIR mental health 55 30154072
2010 Maize global transcriptomics reveals pervasive leaf diurnal rhythms but rhythms in developing ears are largely limited to the core oscillator. PloS one 54 20886102
2014 Connecting ears to eye muscles: evolution of a 'simple' reflex arc. Brain, behavior and evolution 52 24776996
1989 Development of location-specific hair cell stereocilia in denervated embryonic ears. The Journal of comparative neurology 51 2808748
2017 Microbiomes of the normal middle ear and ears with chronic otitis media. The Laryngoscope 47 28397271
2009 Supporting cell characteristics in long-deafened aged mouse ears. Journal of the Association for Research in Otolaryngology : JARO 47 19644644
2006 Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears. Molecular nutrition & food research 47 16404705
2002 Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 47 12191003
2000 Intestinal fatty acid binding protein polymorphism at codon 54 is not associated with postprandial responses to fat and glucose tolerance tests in healthy young Europeans. Results from EARS II participants. Atherosclerosis 46 10998459
1999 Effect of variation in the apo A-IV gene on body mass index and fasting and postprandial lipids in the European Atherosclerosis Research Study II. EARS Group. Journal of lipid research 45 9925658
2000 Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace. Mechanisms of development 44 11025218
1984 The unsafeness of 'safe' ears. The Journal of laryngology and otology 43 6693801
2002 Analysis of spiral ganglion cell populations in children with normal and pathological ears. The Annals of otology, rhinology, and laryngology 42 12498365
2014 The eyes and ears are visual indicators of attention in domestic horses. Current biology : CB 41 25093554
2016 EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer. Oncotarget 40 27612429
2004 Regeneration in the ears of immunodeficient mice: identification and lineage analysis of mesenchymal stem cells. Tissue engineering 40 15363180
2008 Forceps minor region signal abnormality "ears of the lynx": an early MRI finding in spastic paraparesis with thin corpus callosum and mutations in the spatacsin gene (SPG11) on chromosome 15. Journal of neuroimaging : official journal of the American Society of Neuroimaging 39 19040626
1999 Evidence of mast cell activity in the middle ears of children with otitis media with effusion. The Laryngoscope 39 10089978
1998 Linkage disequilibrium at the cystathionine beta synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine. The Ears II Group. European Atherosclerosis Research Study. Annals of human genetics 39 10363126
2019 Potential Application of Lactic Acid Bacteria to Reduce Aflatoxin B1 and Fumonisin B1 Occurrence on Corn Kernels and Corn Ears. Toxins 38 31906161
2013 Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes. The Journal of comparative neurology 37 23124808
2006 Cochlear microphonic potential recorded by transtympanic electrocochleography in normally-hearing and hearing-impaired ears. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 36 16886850
2009 Audiometric, surgical, and genetic findings in 15 ears of patients with osteogenesis imperfecta. The Laryngoscope 35 19358256
2007 Pressure difference receiving ears. Bioinspiration & biomimetics 35 18364558
2011 Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. Hearing research 34 21875659
2021 EPRS/GluRS promotes gastric cancer development via WNT/GSK-3β/β-catenin signaling pathway. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 33 33740160
2018 Visualization of the Membranous Labyrinth and Nerve Fiber Pathways in Human and Animal Inner Ears Using MicroCT Imaging. Frontiers in neuroscience 32 30108474
2013 Saving ears and kidneys from cisplatin. Anticancer research 30 24122981
2009 Ganglion cell and 'dendrite' populations in electric acoustic stimulation ears. Advances in oto-rhino-laryngology 30 19955718
2016 Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons. The Journal of biological chemistry 29 27002157
2012 Birdsong: is it music to their ears? Frontiers in evolutionary neuroscience 29 23226128
2010 Expression of candidate markers for stem/progenitor cells in the inner ears of developing and adult GFAP and nestin promoter-GFP transgenic mice. Gene expression patterns : GEP 28 20817025
1994 The European Atherosclerosis Research Study (EARS): design and objectives. International journal of epidemiology 28 7960370
2009 Levels of compounds and metabolites in wheat ears and grains in organic and conventional agriculture. Journal of agricultural and food chemistry 27 20560625
2001 Sciaenid inner ears: a study in diversity. Brain, behavior and evolution 27 11910172
2019 Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 26 31351099
2016 Electric stimulation of the ears ameliorated learning and memory impairment in rats with cerebral ischemia-reperfusion injury. Scientific reports 26 26847826
1999 A replication-incompetent adenovirus vector with the preterminal protein gene deleted efficiently transduces mouse ears. Journal of virology 26 9882305
2000 Expression of EphA4 in developing inner ears of the mouse and guinea pig. Hearing research 25 10601711
2020 Efficient in Utero Gene Transfer to the Mammalian Inner Ears by the Synthetic Adeno-Associated Viral Vector Anc80L65. Molecular therapy. Methods & clinical development 24 32775487
2020 Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears. International immunopharmacology 23 33246825
2013 EprS, an autotransporter protein of Pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors. Cellular microbiology 23 23311922
2007 What have lizard ears taught us about auditory physiology? Hearing research 23 17983712
2022 Priority screening of contaminant of emerging concern (CECs) in surface water from drinking water sources in the lower reaches of the Yangtze River based on exposure-activity ratios (EARs). The Science of the total environment 22 36162578
2016 Wheat Blast and Fusarium Head Blight Display Contrasting Interaction Patterns on Ears of Wheat Genotypes Differing in Resistance. Phytopathology 22 26574785
2013 Parvoviral left-end hairpin ears are essential during infection for establishing a functional intranuclear transcription template and for efficient progeny genome encapsidation. Journal of virology 22 23903839
1994 The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase. Genomics 22 8188258
2011 Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears. PloS one 21 21909368
2010 Post-treatment effects of local GDNF administration to the inner ears of deafened guinea pigs. Journal of neurotrauma 21 20597638
2008 Otoacoustic emissions from insect ears: evidence of active hearing? Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 21 18516607
2010 Evolutionary analysis of regulatory sequences (EARS) in plants. The Plant journal : for cell and molecular biology 19 20659275
2015 A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss. Hearing research 18 26631688
2006 Molecular analyses of KCNQ1-5 potassium channel mRNAs in rat and guinea pig inner ears: expression, cloning, and alternative splicing. Acta oto-laryngologica 18 16608784
1999 Ventromedial focus of cell death is absent during development of Xenopus and zebrafish inner ears. Journal of neurocytology 18 10900084
2023 An increase in erythromycin resistance in methicillin-susceptible Staphylococcus aureus from blood correlates with the use of macrolide/lincosamide/streptogramin antibiotics. EARS-Net Spain (2004-2020). Frontiers in microbiology 16 37822743
2000 Sequencing and characterization of the cryptic plasmid QpRS from Coxiella burnetii. Plasmid 16 10873529
2021 External ears for non-invasive and stable monitoring of volatile organic compounds in human blood. Scientific reports 15 34112816
2018 Effects of transplanted adipose derived stem cells on the expressions of α-SMA and DCN in fibroblasts of hypertrophic scar tissues in rabbit ears. Experimental and therapeutic medicine 15 30186394
2016 Optimizing cell sourcing for clinical translation of tissue engineered ears. Biofabrication 15 27917821
2022 Aminoacylation-defective bi-allelic mutations in human EPRS1 associated with psychomotor developmental delay, epilepsy, and deafness. Clinical genetics 14 36411955
2020 Anti-inflammatory effects of ginsenoside Rg3 on the hypertrophic scar formation via the NF-κB/IκB signaling pathway in rabbit ears. Die Pharmazie 14 32213242
2020 Effects of Botulinum Toxin Type A on Microvessels in Hypertrophic Scar Models on Rabbit Ears. BioMed research international 14 32626735
2019 The DRS-AIMP2-EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex. IUCrJ 14 31576228
2016 The plant response induced in wheat ears by a combined attack of Sitobion avenae aphids and Fusarium graminearum boosts fungal infection and deoxynivalenol production. Molecular plant pathology 14 26918628
2016 Genome-Wide Identification of miRNAs and Their Targets Involved in the Developing Internodes under Maize Ears by Responding to Hormone Signaling. PloS one 14 27695059
2015 Efficacy of elective nodal irradiation in skin squamous cell carcinoma of the face, ears, and scalp. Radiation oncology (London, England) 14 26391010
2012 Microcornea with myopic chorioretinal atrophy, telecanthus and posteriorly-rotated ears: a distinct clinical syndrome. Ophthalmic genetics 14 22686506
2009 Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss. Genes, brain, and behavior 14 19737145
2023 Lend Me Your EARs: A Systematic Review of the Broad Functions of EAR Motif-Containing Transcriptional Repressors in Plants. Genes 13 36833197
2020 Functional anatomy of the middle and inner ears of the red fox, in comparison to domestic dogs and cats. Journal of anatomy 13 32068262
1990 Analysis of QpRS-specific sequences from Coxiella burnetii. Annals of the New York Academy of Sciences 12 2378474

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