Affinage

SLC27A1

Long-chain fatty acid transport protein 1 · UniProt Q6PCB7

Length
646 aa
Mass
71.1 kDa
Annotated
2026-04-28
100 papers in source corpus 23 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC27A1 (FATP1) is an acyl-CoA synthetase that couples long-chain and very long-chain fatty acid activation to cellular uptake via metabolic trapping, functioning as a central node linking fatty acid import to oxidation, storage, and signaling in metabolically active tissues. The enzyme preferentially activates very long-chain substrates (C24:0 > C16:0) and resides primarily on the endoplasmic reticulum and mitochondrial outer membrane, with insulin stimulating its translocation to the plasma membrane in adipocytes and muscle to drive fatty acid uptake; loss of FATP1 abolishes insulin-stimulated fatty acid import while leaving basal uptake intact (PMID:10593920, PMID:16611988, PMID:23024797). At mitochondria, FATP1 physically associates with CPT1 to channel fatty acids into β-oxidation and generates AMP through its synthetase reaction to activate AMPK, coupling lipid flux to energy-sensing signaling (PMID:19429947, PMID:19560442, PMID:20667975). Beyond canonical lipid metabolism, FATP1 governs macrophage inflammatory reprogramming by controlling the balance between fatty acid and glucose utilization, mediates DHA transport across the blood–brain barrier, interacts with RPE65/LRAT to modulate retinoid isomerase activity in the visual cycle, and is exploited by melanoma cells to acquire adipocyte-derived lipids for tumor growth (PMID:27408776, PMID:28035674, PMID:20356843, PMID:29903879).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1999 High

    Establishing that FATP1 is not merely a passive transporter but an enzyme with intrinsic very long-chain acyl-CoA synthetase activity answered the fundamental question of how FATP proteins facilitate fatty acid uptake — through metabolic activation rather than channel-like transport.

    Evidence Acyl-CoA synthetase assay and active-site mutagenesis of FATP1-Myc/His in COS1 cells

    PMID:10593920

    Open questions at the time
    • No crystal structure or detailed active-site topology
    • Substrate specificity across all physiological fatty acid species not fully mapped
    • Mechanism of membrane topology not resolved
  2. 2000 High

    Cross-species complementation demonstrated that FATP1 is a functional orthologue of yeast Fat1p with dual transport and activation activities, validating that these coupled functions are evolutionarily conserved.

    Evidence Complementation of yeast fat1Δ strains with murine FATP1, measuring transport, acyl-CoA synthetase activity, and β-oxidation

    PMID:10880966

    Open questions at the time
    • Relative contribution of transport versus activation to net uptake not dissected in mammalian cells
    • Whether FATP1 forms homodimers or oligomers unresolved
  3. 2005 High

    Systematic comparison of all six FATP isoforms revealed that only FATP1, FATP2, and FATP4 possess dual transport/activation capability, delineating the functional subgroups within the family and clarifying tissue-specific division of labor.

    Evidence Expression of mmFATP1–6 in fat1Δ faa1Δ yeast with transport and synthetase assays

    PMID:15699031

    Open questions at the time
    • Isoform-specific protein–protein interactions not compared
    • Tissue-specific regulation of isoform switching not addressed
  4. 2006 High

    The FATP1 knockout mouse resolved whether FATP1 mediates basal or regulated fatty acid uptake in vivo, showing that it is specifically required for insulin-stimulated — but not basal — long-chain fatty acid uptake in adipocytes and muscle, and that its loss redistributes dietary lipid to the liver.

    Evidence FATP1 knockout mice with insulin-stimulated fatty acid uptake assays in isolated adipocytes and skeletal muscle, subcellular fractionation, in vivo metabolic phenotyping

    PMID:16611988

    Open questions at the time
    • Signaling cascade connecting insulin receptor to FATP1 translocation not identified
    • Compensatory roles of other FATPs in KO tissues not quantified
  5. 2009 High

    Discovery that FATP1 localizes to mitochondria and physically interacts with CPT1 established a direct mechanistic link between fatty acid activation at the outer mitochondrial membrane and entry into β-oxidation, while the parallel finding that FATP1-generated AMP activates AMPK connected lipid uptake to cellular energy sensing.

    Evidence Co-immunoprecipitation of FATP1–CPT1 in myotubes, etomoxir epistasis, AMPK/ACC phosphorylation and AMP/ATP ratio measurements after FATP1 knockdown in adipocytes

    PMID:19429947 PMID:19560442

    Open questions at the time
    • Direct binding interface between FATP1 and CPT1 not mapped
    • Whether FATP1-AMPK axis operates in tissues beyond adipocytes and muscle not tested
    • Stoichiometry of AMP production relative to other AMP sources unknown
  6. 2010 High

    Identification of FATP1 interaction with RPE65 and LRAT in the retinal pigment epithelium extended its functional repertoire beyond lipid metabolism to visual cycle regulation, showing it inhibits 11-cis retinol production.

    Evidence Yeast two-hybrid, co-localization, and cellular reconstitution of RPE65–FATP1 interaction with retinol isomerase activity assay

    PMID:20356843

    Open questions at the time
    • Physiological relevance in FATP1 KO retina not tested
    • Whether acyl-CoA synthetase activity is required for visual cycle modulation unclear
  7. 2012 High

    Demonstrating that overexpressed FATP1 resides on the ER rather than the plasma membrane in adipocytes — and that insulin enhances uptake without changing FATP1 localization — strengthened the metabolic trapping model over a direct transporter model.

    Evidence Confocal microscopy and subcellular fractionation of retrovirally transduced FATP1 in 3T3-L1 adipocytes with fatty acid uptake assays

    PMID:23024797

    Open questions at the time
    • Contradicts earlier translocation findings; whether endogenous versus overexpressed FATP1 differs in trafficking remains unresolved
    • Identity of the plasma membrane component that collaborates with ER-resident FATP1 not identified
  8. 2014 High

    Immunogold EM pinpointed FATP1 to the mitochondrial outer membrane and intermembrane space in skeletal muscle, resolving its submitochondrial location and showing it promotes complete fatty acid oxidation to CO2 while suppressing ketone body oxidation.

    Evidence Immunogold EM, differential centrifugation, palmitate and β-hydroxybutyrate oxidation assays in FATP1-overexpressing mouse skeletal muscle

    PMID:24858472

    Open questions at the time
    • How FATP1 suppresses ketone body oxidation mechanistically not explained
    • Whether intermembrane space pool is functionally distinct from outer membrane pool unknown
  9. 2016 High

    Loss-of-function and gain-of-function experiments in macrophages revealed that FATP1 controls the fatty acid–glucose metabolic switch that governs inflammatory polarization, expanding FATP1's role from metabolic tissues to innate immunity.

    Evidence Fatp1−/− bone marrow-derived macrophages, FATP1-overexpressing RAW 264.7 cells, bone marrow transplant chimeras on high-fat diet

    PMID:27408776

    Open questions at the time
    • Specific fatty acid species mediating anti-inflammatory effect not identified
    • Whether FATP1-AMPK axis contributes to macrophage reprogramming not tested
  10. 2017 High

    Quantitative knockdown established that FATP1 accounts for 59–73% of DHA uptake across brain microvascular endothelial cells and mediates insulin-stimulated DHA transport at the blood–brain barrier, defining a tissue-specific substrate preference.

    Evidence siRNA knockdown in hCMEC/D3 cells, [14C]-DHA uptake assays, immunohistochemistry of mouse brain microvessels

    PMID:28035674

    Open questions at the time
    • In vivo BBB-specific FATP1 deletion not performed
    • Whether FATP1 cooperates with Mfsd2a for brain DHA supply unclear
  11. 2018 High

    Demonstration that melanoma cells exploit FATP1 to acquire adipocyte-derived lipids, and that FATP1 cooperates with BRAFV600E in zebrafish melanomagenesis, identified FATP1 as a druggable oncogenic dependency in melanoma.

    Evidence Co-culture lipid transfer assays, FATP1 transgenic zebrafish, mouse xenografts, Lipofermata pharmacologic inhibition

    PMID:29903879

    Open questions at the time
    • Lipofermata selectivity across FATP isoforms not fully characterized
    • Mechanism by which fatty acid import promotes invasion not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of FATP1 catalysis and membrane topology, the precise signaling intermediates linking insulin receptor activation to FATP1 translocation, the reconciliation of ER-resident versus plasma membrane translocation models, and whether the FATP1-CPT1 interaction is regulated by metabolic state.
  • No crystal or cryo-EM structure available
  • Insulin-to-FATP1 translocation signaling cascade unmapped
  • ER versus plasma membrane localization discrepancy unresolved across cell types

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 3 GO:0008289 lipid binding 3 GO:0016874 ligase activity 3 GO:0098772 molecular function regulator activity 1
Localization
GO:0005739 mitochondrion 3 GO:0005886 plasma membrane 3 GO:0005783 endoplasmic reticulum 2
Pathway
R-HSA-1430728 Metabolism 7 R-HSA-162582 Signal Transduction 3 R-HSA-382551 Transport of small molecules 2 R-HSA-168256 Immune System 1 R-HSA-9709957 Sensory Perception 1
Partners
ACSL1CPT1ALRATRPE65

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 FATP1 (SLC27A1) possesses very long chain acyl-CoA synthetase activity, preferentially activating C24:0 over C16:0; active-site mutagenesis (M1: substitution in putative active site residues 249-254; M2: deletion of conserved C-terminal domain residues 464-523) abolished catalytic activity, indicating both domains are required for enzymatic function. Expression of FATP1-Myc/His in COS1 cells, acyl-CoA synthetase activity assay, active-site mutagenesis, nickel-affinity purification The Journal of biological chemistry High 10593920
1999 FATP1 localizes to both the plasma membrane and intracellular membranes in COS1 cells, as determined by immunolocalization of tagged fusion protein. Immunolocalization of FATP1-Myc/His in COS1 cells The Journal of biological chemistry Medium 10593920
2000 Murine FATP1 functionally complements yeast fat1Δ strains, restoring long-chain fatty acid transport, very long chain acyl-CoA synthetase activity, and beta-oxidation of exogenous fatty acids, establishing that FATP1 and yeast Fat1p are functional homologues with dual roles in fatty acid transport and activation. Yeast complementation assay in fat1Δ strains, fatty acid transport assay, acyl-CoA synthetase activity assay, beta-oxidation assay European journal of biochemistry High 10880966
2000 Human SLC27A1/FATP-1 mRNA is most highly expressed in muscle and adipose tissue, with intermediate levels in small intestine and barely detectable levels in liver; the gene spans >13 kb, contains 12 exons, and maps to chromosome 19p13.1. cDNA and gene cloning, Northern blot expression analysis, fluorescence in situ hybridization Genomics Medium 10873384
2002 FATP1 preferentially channels exogenous long-chain fatty acids into triacylglycerol (TG) biosynthesis in 293 cells, increasing DGAT activity, while simultaneously down-regulating de novo sphingomyelin and cholesterol biosynthesis. Stable overexpression of FATP1 in 293 cells, radiolabeled lipid incorporation assays ([14C]acetate, [3H]oleic acid, [14C]lignoceric acid), DGAT activity assay Journal of lipid research Medium 12235169
2005 Among the six murine FATP isoforms expressed in yeast, FATP1 (along with FATP2 and FATP4) complements both fatty acid transport and very long chain fatty acid activation defects of fat1Δ faa1Δ yeast, whereas FATP3, 5, and 6 do not complement transport; FATP1 activates C18:1, C20:4 as substrates. Expression of mmFATP1-6 in fat1Δ faa1Δ yeast, fatty acid transport assays, acyl-CoA synthetase activity assays, subcellular localization The Journal of biological chemistry High 15699031
2005 FATP1 localizes in an intracellular reticular pattern and perinuclear region (partly overlapping with Golgi marker GM-130), distinct from FAT/CD36 which localizes to the extracellular membrane; both proteins similarly stimulate palmitate and oleate transport and incorporation into triacylglyceride in human muscle cells. Adenoviral delivery of FATP1-EGFP and FAT-EGFP fusion proteins in primary cultured human muscle cells, confocal microscopy, radiolabeled fatty acid transport and oxidation assays American journal of physiology. Cell physiology Medium 15897321
2006 FATP1 is an insulin-sensitive fatty acid transporter: insulin stimulates translocation of FATP1 from an intracellular compartment to the plasma membrane in adipocytes and skeletal muscle, and insulin-stimulated fatty acid uptake is completely abolished in FATP1-null adipocytes and greatly reduced in FATP1-knockout skeletal muscle, while basal LCFA uptake is unaffected. Loss of FATP1 redistributes dietary lipids from adipose/muscle to liver and protects against diet-induced obesity. FATP1 knockout mice, insulin-stimulated fatty acid uptake assays in isolated adipocytes and skeletal muscle, subcellular fractionation, in vivo metabolic studies Molecular and cellular biology High 16611988
2009 FATP1 localizes to mitochondria in L6E9 myotubes and rat skeletal muscle, co-immunoprecipitates with carnitine palmitoyltransferase 1 (CPT1), and overexpression of FATP1 increases both fatty acid oxidation and palmitate esterification; etomoxir (irreversible CPT1 inhibitor) blocks all FATP1-mediated effects on mitochondrial fatty acid oxidation. Adenoviral overexpression in L6E9 myotubes, immunocytochemistry, co-immunoprecipitation, fatty acid oxidation and esterification assays, etomoxir inhibition Journal of lipid research High 19429947
2009 FATP1 localizes to mitochondria in cultured myotubes (confirmed by subcellular fractionation and immunocytology of FATP1-GFP), and stimulates CO2 production from glucose while raising pyruvate dehydrogenase (PDH) complex activity and activating the PDH-E1 catalytic subunit. Subcellular fractionation, immunocytology of FATP1-GFP, PDH complex activity assay, glucose oxidation assays Mitochondrion Medium 19361580
2009 FATP1-dependent production of AMP (via acyl-CoA synthetase activity) activates AMP-activated protein kinase (AMPK) in 3T3-L1 adipocytes; insulin-stimulated palmitate or arachidonate uptake increases AMPK and ACC phosphorylation, and shRNA knockdown of FATP1 attenuates fatty acid-induced AMPK activation. shRNA knockdown of FATP1 in 3T3-L1 adipocytes, AMPK/ACC phosphorylation assays, AMP/ATP ratio measurement, FATP4 proteoliposome AMP production assay Biochemical and biophysical research communications Medium 19560442
2010 FATP1 and Acsl1 are required for AMPK activation by both adiponectin and insulin in mouse adipocytes; knockdown of FATP1 eliminates the insulin- and adiponectin-induced rise in AMP/ATP ratio and AMPK activation, demonstrating that FATP1's acyl-CoA synthetase activity drives AMP generation to activate AMPK. siRNA knockdown of FATP1 and Acsl1 in mouse adipocytes, AMP/ATP ratio measurement, AMPK activation assays, fatty acid uptake assays FASEB journal Medium 20667975
2010 FATP1 (SLC27A1) interacts with RPE65 and lecithin:retinol acyltransferase (LRAT) in the retinal pigment epithelium, inhibiting 11-cis retinol production by acting on retinyl ester production and RPE65 isomerase activity; the cytosolic C-terminal sequence of FATP1 mediates the interaction with RPE65. Yeast two-hybrid screen with RPE65, dose-dependent interaction assay, co-localization, cellular reconstitution of interacting proteins, retinol isomerase activity assay The Journal of biological chemistry High 20356843
2011 Overexpression of FATP1 in rat soleus muscle increases palmitate transport and oxidation (but not triacylglycerol esterification), and muscle-specific FATP1 transgenic mice do not develop insulin resistance or intramuscular lipid accumulation on high-fat diet, indicating FATP1 channels fatty acids to oxidation rather than storage in skeletal muscle. Transient Fatp1 overexpression in isolated soleus, muscle-specific transgenic mice (Mck/Fatp1), in vivo metabolic studies, fatty acid transport and oxidation assays Diabetologia High 21442160
2012 In 3T3-L1 adipocytes, overexpressed FATP1 and ACSVL4/FATP4 localize to the endoplasmic reticulum (not the plasma membrane), as determined by confocal microscopy and subcellular fractionation; insulin increases fatty acid uptake without changing FATP1 localization, suggesting that enhanced fatty acid uptake by these proteins occurs via metabolic trapping rather than direct plasma membrane transport. Retroviral transduction of FATP1, FATP4, ACSL1 in 3T3-L1 adipocytes, confocal microscopy, subcellular fractionation, acyl-CoA synthetase activity assay, fatty acid uptake assay PloS one High 23024797
2014 FATP1 protein is most abundant in purified mitochondria (specifically in the outer membrane and soluble intermembrane subfraction, not the inner membrane/matrix) of mouse gastrocnemius muscle; overexpression enhances disposal of systemic fatty acids and intramuscular triglycerides and increases palmitate oxidation to CO2, while inhibiting ketone body oxidation. Differential centrifugation and subcellular fractionation, immunogold electron microscopy of FATP1-GFP in myotubes, adenovirus-mediated FATP1 overexpression in mouse skeletal muscle, palmitate and beta-hydroxybutyrate oxidation assays PloS one High 24858472
2016 FATP1 displays acyl-CoA synthetase activity for long-chain fatty acids in macrophages; loss of FATP1 in macrophages enhances glucose metabolism and exacerbates pro-inflammatory (classically activated) macrophage phenotype, while overexpression of FATP1 decreases glucose metabolism and attenuates inflammation, demonstrating FATP1 regulates macrophage metabolic reprogramming and inflammatory tone. Fatp1-/- BMDM metabolomics, bioenergetics and inflammatory phenotyping; FATP1-overexpressing RAW 264.7 cells; bone marrow transplant chimeric mice on high-fat diet; flow cytometry, histology, acyl-CoA synthetase activity assay Molecular metabolism High 27408776
2017 FATP1/SLC27A1 at the blood-brain barrier mediates uptake of docosahexaenoic acid (DHA) into brain microvascular endothelial cells, accounting for 59-73% of total DHA uptake; FATP1 also mediates DHA efflux; insulin treatment induces translocation of FATP1 to the plasma membrane in hCMEC/D3 cells and enhances DHA uptake; FATP1 is preferentially localized at the basal membrane of brain microvessels in mouse brain. FATP1 overexpression in HEK293 cells, siRNA knockdown in hCMEC/D3 cells, [14C]-DHA uptake assays, immunohistochemistry of mouse brain sections, subcellular localization after insulin treatment Journal of neurochemistry High 28035674
2018 Among SLC27A family members, melanomas significantly overexpress FATP1/SLC27A1; adipocyte-derived lipids are transferred to melanoma cells via FATP/SLC27A family transporters at the tumor cell surface; pharmacologic blockade of FATPs with Lipofermata reduces lipid transport, melanoma growth and invasion; melanocyte-specific FATP1 expression cooperates with BRAFV600E in transgenic zebrafish to accelerate melanoma. In vitro co-culture lipid transfer assays, FATP1 transgenic zebrafish, mouse xenograft studies, small-molecule FATP inhibitor (Lipofermata), expression analysis Cancer discovery High 29903879
2019 PPARα and PPARγ activation suppresses Fatp1 expression in macrophages, attenuating oleate-induced free fatty acid and triglyceride accumulation; TNF-α inhibition of Fatp1 similarly reduces lipid accumulation, placing Fatp1 downstream of PPAR signaling in macrophage lipid influx. PPAR agonist treatment (WY14643, pioglitazone) and TNF-α treatment of macrophages, metabolomics, Fatp1 expression analysis, fatty acid uptake assays Cell death & disease Medium 30674874
2019 Estrogen receptor-β (ER-β) regulates FATP1/SLC27A1 expression, fatty acid uptake, and cell viability in breast cancer cell lines; FATP1 inhibition with arylpiperazine 5k (DS22420314) reduces fatty acid uptake and cell viability. Estradiol and ER-β antagonist (PHTPP) treatment in four breast cancer cell lines, FATP1 expression analysis, fatty acid uptake assay, cell viability assay, FATP1 inhibitor treatment Scientific reports Medium 31575907
2022 Withaferin A (WA) induces white adipose tissue browning through upregulation of Prdm16 and FATP1 (Slc27a1) in inguinal WAT; this effect is blocked by sympathetic chemical denervation, and knockdown of Prdm16 or FATP1 in iWAT abrogates WA-induced browning and weight loss, placing FATP1 downstream of the sympathetic nerve-Prdm16 axis in adipose browning. Withaferin A treatment in mice, sympathetic denervation, Prdm16 and FATP1 knockdown in inguinal WAT, energy expenditure measurement, adipose browning assays Diabetes Medium 34732538
2024 Iron reduces FATP1 protein abundance (by ~19.7%) in human brain microvascular endothelial cells without affecting mRNA, and this is associated with up to 32.6% reduction in DHA efflux, demonstrating post-transcriptional regulation of FATP1 protein levels by iron with a direct functional consequence on DHA transport. Ferric ammonium citrate (FAC) treatment of hCMEC/D3 cells, RT-qPCR, Western blot, [14C]-DHA and [3H]-oleic acid uptake and efflux assays Pharmaceutical research Medium 39044044
2025 Downregulation of SLC27A1 in colorectal cancer cell lines (Caco-2 and T84) significantly inhibits cell migration and invasion, and SLC27A1-mediated transport of long-chain fatty acids promotes synthesis of diacylglycerol-3-phosphate (DAG-3P), which is mechanistically linked to CRC metastasis. SLC27A1 knockdown in Caco-2 and T84 cells, cell migration and invasion assays, computational analysis of CTC/tumor transcriptome data Scientific reports Low 40883416

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Physiological reviews 454 26269524
2018 Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins. Cancer discovery 299 29903879
2006 FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Molecular and cellular biology 225 16611988
1999 Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. Biochimica et biophysica acta 206 10526223
1999 The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase. The Journal of biological chemistry 190 10593920
2017 Ca2+ binding to F-ATP synthase β subunit triggers the mitochondrial permeability transition. EMBO reports 180 28507163
2019 Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore. Nature communications 155 31554800
2003 Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. The Journal of cell biology 154 12821645
2009 Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle. The Journal of biological chemistry 146 19380575
2005 Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast. The Journal of biological chemistry 108 15699031
2016 Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Molecular metabolism 105 27408776
2006 Catalytic and mechanical cycles in F-ATP synthases. Fourth in the Cycles Review Series. EMBO reports 103 16607397
2017 The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH. EMBO reports 98 29217657
2009 Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. Journal of lipid research 94 19429947
2004 Role of FATP in parenchymal cell fatty acid uptake. Biochimica et biophysica acta 83 15522816
2004 The ion channel of F-ATP synthase is the target of toxic organotin compounds. Proceedings of the National Academy of Sciences of the United States of America 74 15277681
2011 Two rotary motors in F-ATP synthase are elastically coupled by a flexible rotor and a stiff stator stalk. Proceedings of the National Academy of Sciences of the United States of America 72 21368147
2012 Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes. PloS one 71 23024797
2002 FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells. Journal of lipid research 68 12235169
2021 Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase. Nature communications 67 34376679
2019 PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression. Cell death & disease 65 30674874
2010 Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 62 20667975
2005 Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. American journal of physiology. Cell physiology 61 15897321
2007 The fatty acid transport protein (FATP) family: very long chain acyl-CoA synthetases or solute carriers? Journal of molecular neuroscience : MN 60 17901542
2017 Lower Expression of SLC27A1 Enhances Intramuscular Fat Deposition in Chicken via Down-Regulated Fatty Acid Oxidation Mediated by CPT1A. Frontiers in physiology 58 28706492
1999 Fatty acid transporters (FABPpm, FAT, FATP) in human muscle. Canadian journal of applied physiology = Revue canadienne de physiologie appliquee 54 10638339
2017 The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport. Journal of neurochemistry 53 28035674
2016 Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase. Antimicrobial agents and chemotherapy 47 27620476
2019 TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase. Antimicrobial agents and chemotherapy 46 31358589
2016 Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis-driven H(+) pumping. The FEBS journal 46 26996828
2020 The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore. Cell reports 45 32877677
2000 The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. Genomics 44 10873384
2020 Structural and functional properties of plant mitochondrial F-ATP synthase. Mitochondrion 43 32534049
2018 Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. PLoS genetics 42 30199545
2000 Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains. European journal of biochemistry 42 10880966
2011 Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance. Diabetologia 41 21442160
2021 The role of FATP1 in lipid accumulation: a review. Molecular and cellular biochemistry 38 33486652
2020 Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines. Angewandte Chemie (International ed. in English) 38 32337801
2006 Expression pattern of fatty acid transport protein-1 (FATP-1), FATP-4 and heart-fatty acid binding protein (H-FABP) genes in human term placenta. Early human development 36 16574350
2022 The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation. Cell death and differentiation 35 35614131
2018 The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine. The FEBS journal 35 29360236
2017 The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation. The Journal of biological chemistry 34 28495884
2005 Structural evidence for a constant c11 ring stoichiometry in the sodium F-ATP synthase. The FEBS journal 32 16262688
2016 Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China. Scientific reports 31 26867681
2019 Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis. Scientific reports 29 31727946
2019 Mitochondrial F-ATP Synthase and Its Transition into an Energy-Dissipating Molecular Machine. Oxidative medicine and cellular longevity 28 31178976
2015 The molecular motor F-ATP synthase is targeted by the tumoricidal protein HAMLET. Journal of molecular biology 28 25681694
2012 Decreased expression of adipose CD36 and FATP1 are associated with increased plasma non-esterified fatty acids during prolonged fasting in northern elephant seal pups (Mirounga angustirostris). The Journal of experimental biology 27 22723485
2014 Fatty acid transport protein 1 (FATP1) localizes in mitochondria in mouse skeletal muscle and regulates lipid and ketone body disposal. PloS one 26 24858472
2019 Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy. Scientific reports 25 31575907
2017 The blood-brain barrier and protein-mediated fatty acid uptake: role of the blood-brain barrier as a metabolic barrier: An Editorial Comment for 'The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport'. Journal of neurochemistry 24 28369884
2019 Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design. Progress in biophysics and molecular biology 22 31743686
2015 Danqi Pill regulates lipid metabolism disorder induced by myocardial ischemia through FATP-CPTI pathway. BMC complementary and alternative medicine 21 25885422
2006 Structural and functional characterization of the bovine solute carrier family 27 member 1 (SLC27A1) gene. Cytogenetic and genome research 21 17065791
2022 Withaferin A Promotes White Adipose Browning and Prevents Obesity Through Sympathetic Nerve-Activated Prdm16-FATP1 Axis. Diabetes 19 34732538
2013 Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorganic & medicinal chemistry letters 19 23528296
2022 Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase. Current research in structural biology 18 36186842
2012 Solution structure of subunit γ (γ(1-204)) of the Mycobacterium tuberculosis F-ATP synthase and the unique loop of γ(165-178), representing a novel TB drug target. Journal of bioenergetics and biomembranes 18 23104121
2020 The Unique C-Terminal Extension of Mycobacterial F-ATP Synthase Subunit α Is the Major Contributor to Its Latent ATP Hydrolysis Activity. Antimicrobial agents and chemotherapy 17 32988828
2010 Cloning and functional characterization of a fatty acid transport protein (FATP) from the pheromone gland of a lichen moth, Eilema japonica, which secretes an alkenyl sex pheromone. Insect biochemistry and molecular biology 17 20875854
2009 FATP1 localizes to mitochondria and enhances pyruvate dehydrogenase activity in skeletal myotubes. Mitochondrion 17 19361580
2019 Structural Asymmetry and Kinetic Limping of Single Rotary F-ATP Synthases. Molecules (Basel, Switzerland) 16 30704145
2012 FATP1 silence inhibits the differentiation and induces the apoptosis in chicken preadipocytes. Molecular biology reports 16 23187737
2009 FATP1 mediates fatty acid-induced activation of AMPK in 3T3-L1 adipocytes. Biochemical and biophysical research communications 16 19560442
2008 [The role of fatty-acid transport proteins (FAT/CD36, FABPpm, FATP) in lipid metabolism in skeletal muscles]. Postepy higieny i medycyny doswiadczalnej (Online) 15 18772848
2010 FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase. The Journal of biological chemistry 14 20356843
2018 Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε. Journal of structural biology 13 30342092
2017 Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice. Atherosclerosis 13 29035781
2012 Fatp1 deficiency affects retinal light response and dark adaptation, and induces age-related alterations. PloS one 13 23166839
2022 Mutational Analysis of Mycobacterial F-ATP Synthase Subunit δ Leads to a Potent δ Enzyme Inhibitor. ACS chemical biology 12 35148057
2022 Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1. Antimicrobial agents and chemotherapy 11 35481752
2022 Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor. The FEBS journal 11 35612822
2021 Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT. Molecules (Basel, Switzerland) 11 34770872
2018 Expression of APOB, ADFP and FATP1 and their correlation with fat deposition in Yunnan's top six famous chicken breeds. British poultry science 10 30004246
2014 Crystallographic structure of the turbine C-ring from spinach chloroplast F-ATP synthase. Bioscience reports 10 27919036
2024 High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo. The Journal of biological chemistry 9 38176652
2021 The Effect of FATP1 on Adipocyte Differentiation in Qinchuan Beef Cattle. Animals : an open access journal from MDPI 9 34679811
2012 Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors. Bioorganic & medicinal chemistry letters 9 22749869
2019 Purification of Functional F-ATP Synthase from Blue Native PAGE. Methods in molecular biology (Clifton, N.J.) 7 30674031
2019 Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase. Biochemical and biophysical research communications 7 31761325
2025 SQ31f is a potent non-tuberculous mycobacteria antibiotic by specifically targeting the mycobacterial F-ATP synthase. The Journal of antimicrobial chemotherapy 6 39499211
2024 Human F-ATP synthase as a drug target. Pharmacological research 6 39303772
2022 The SLC27A1 Gene and Its Enriched PPAR Pathway Are Involved in the Regulation of Flavor Compound Hexanal Content in Chinese Native Chickens. Genes 6 35205238
2019 The structural features of Acetobacterium woodii F-ATP synthase reveal the importance of the unique subunit γ-loop in Na+ translocation and ATP synthesis. The FEBS journal 6 30791207
2015 Stoichiometry and deletion analyses of subunits in the heterotrimeric F-ATP synthase c ring from the acetogenic bacterium Acetobacterium woodii. The FEBS journal 6 26613566
2013 Two-dimensional crystallization of intact F-ATP synthase isolated from bovine heart mitochondria. Acta crystallographica. Section F, Structural biology and crystallization communications 6 24316832
2010 Association of FATP1 gene polymorphisms with chicken carcass traits in Chinese meat-type quality chicken populations. Molecular biology reports 6 20204526
2024 N-terminal cleavage of cyclophilin D boosts its ability to bind F-ATP synthase. Communications biology 5 39528709
2023 F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α. Frontiers in oncology 5 37469400
2023 Mitochondrial F-ATP Synthase Co-Migrating Proteins and Ca2+-Dependent Formation of Large Channels. Cells 5 37830628
2011 Association between polymorphisms in the SLC27A1 gene and milk production traits in Chinese Holstein cattle. Animal biotechnology 5 21328100
2024 F-ATP synthase inhibitory factor 1 and mitochondria-organelle interactions: New insight and implications. Pharmacological research 4 39233058
2022 Single-molecule FRET combined with electrokinetic trapping reveals real-time enzyme kinetics of individual F-ATP synthases. Nanoscale 4 35084006
2025 Water occupancy in the Acinetobacter baumannii F-ATP synthase c-ring and its implications as a novel inhibitor target. Structure (London, England : 1993) 3 39892380
2024 Iron Reduces the Trafficking of Fatty Acids from Human Immortalised Brain Microvascular Endothelial Cells Through Modulation of Fatty Acid Transport Protein 1 (FATP1/SLC27A1). Pharmaceutical research 3 39044044
2024 Rice Protein Reduces Triglyceride Levels through Modulating CD36, MTP, FATP, and FABP Expression in Growing and Adult Rats. Foods (Basel, Switzerland) 3 39272469
2023 Large-scale column-free purification of bovine F-ATP synthase. The Journal of biological chemistry 3 38159856
2022 The involvement of FATP1 regulating skeletal muscle fat deposition in stressed broilers was affected by fatty acid substrates. Frontiers in veterinary science 3 35909684
2015 Genetic polymorphisms of the FATP1 gene and their associations with meat quality traits in Chinese Qinchuan cattle. Genetics and molecular research : GMR 3 26782386
2025 Long chain fatty acid transport via SLC27A1 enhances DAG-3-P synthesis and accelerates colorectal cancer metastasis. Scientific reports 2 40883416