Affinage

ACSL1

Long-chain-fatty-acid--CoA ligase 1 · UniProt P33121

Length
698 aa
Mass
77.9 kDa
Annotated
2026-06-09
100 papers in source corpus 30 papers cited in narrative 30 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ACSL1 is a long-chain acyl-CoA synthetase that activates free fatty acids (C10–C18 saturated, plus palmitoleate, oleate, and linoleate) to acyl-CoA thioesters, the committed first step that channels fatty acids into oxidative and biosynthetic fates (PMID:8973631). Its enzymatic activity requires all five structural regions of the protein and can be allosterically tuned by direct sterol binding to a pocket in its acetyl-CoA synthetase-like domain (PMID:8973631, PMID:39799570), and it also thioesterifies xenobiotic 2-arylpropionic acid NSAIDs with stereoselectivity, mediating their chiral inversion (PMID:10725307). The central organizing principle of ACSL1 biology is that its subcellular partitioning between mitochondria and ER dictates metabolic outcome: mitochondrial scaffolding by unphosphorylated TBK1 and by an interaction of its N-terminal 100 residues with CPT1b localizes ACSL1 to the outer mitochondrial membrane to drive β-oxidation, whereas loss of this scaffolding, sortilin-mediated endolysosomal degradation, or acetyl-CoA accumulation redirects ACSL1 to the ER toward fatty acid re-esterification, lipid droplet biogenesis, and hepatic steatosis (PMID:33152322, PMID:34511469, PMID:39232011, PMID:40692014). MCL-1 binds ACSL1 through a non-canonical BH3 interaction with its anti-apoptotic groove and is specifically required for long-chain FAO (PMID:38503284). By trapping fatty acids as acyl-CoAs, ACSL1 promotes cellular fatty acid uptake and supplies AMP that activates AMPK signaling (PMID:22022213, PMID:20667975). ACSL1 channels linoleate into ω-O-acylceramide synthesis essential for the skin barrier, and its genetic loss causes embryonic lethality and barrier defects in mice (PMID:34813948). Through incorporation of polyunsaturated fatty acids into triacylglycerols it drives lipid peroxidation and ferroptosis (PMID:33854057), while in cancer cells its production of myristoyl-CoA supports protein N-myristoylation that stabilizes FSP1 and confers ferroptosis resistance (PMID:33082557, PMID:36882396). In monocytes and macrophages ACSL1 acts upstream of MAPK/NF-κB inflammatory signaling independently of β-oxidation or ceramide synthesis (PMID:30845379, PMID:34299302). ACSL1 transcription is controlled by SREBP2 via a sterol regulatory element, by FXR, CHREBP, and NF-κB, and by epigenetic regulators including PRMT1-controlled H4R3 methylation at its promoter (PMID:26728456, PMID:30580099, PMID:36054206, PMID:37144835).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 1996 High

    Established ACSL1 as a bona fide long-chain acyl-CoA synthetase with defined substrate preference and a multi-region structural requirement for catalysis, answering what reaction the enzyme performs.

    Evidence Purified recombinant rat enzyme, in vitro activity assays, and deletion mutagenesis of five structural regions

    PMID:8973631

    Open questions at the time
    • Did not resolve subcellular targeting or physiological substrate channeling
    • No high-resolution structure of the catalytic mechanism
  2. 2000 High

    Extended ACSL1 substrate scope to xenobiotics, showing it stereoselectively thioesterifies 2-arylpropionic NSAIDs and mediates their chiral inversion in liver.

    Evidence Purified recombinant enzyme with Michaelis-Menten kinetics on R/S enantiomers

    PMID:10725307

    Open questions at the time
    • In vitro only; physiological contribution in vivo not quantified
  3. 2011 Medium

    Linked ACSL1 localization to function, showing mitochondrial ACSL1 drives fatty acid uptake by metabolic trapping rather than acting as a plasma-membrane transporter.

    Evidence Confocal imaging, subcellular fractionation, and radiolabeled/fluorescent FA uptake assays in hepatoma cells and adipocytes

    PMID:22022213 PMID:23024797

    Open questions at the time
    • Based on overexpression, which may bias localization
    • Did not address what controls mitochondrial vs ER targeting
  4. 2010 Medium

    Placed ACSL1 enzymatic activity upstream of AMPK activation, connecting fatty acid activation to energy-sensing signaling.

    Evidence siRNA knockdown in adipocytes with AMP/ATP and AMPK phosphorylation readouts

    PMID:20667975

    Open questions at the time
    • Mechanism linking acyl-CoA synthesis to AMP generation not fully resolved
  5. 2016 High

    Identified direct transcriptional control of ACSL1 by SREBP2 through a sterol regulatory element, tying ACSL1 expression to cholesterol/lipid homeostasis.

    Evidence Promoter reporter with SRE mutagenesis, DNA-binding assay, SREBP2 knockdown, and in vivo statin models in two species

    PMID:26728456

    Open questions at the time
    • Restricted to the C-promoter transcript variant
    • Did not address other promoter elements
  6. 2018 High

    Showed hepatic ACSL1 is required for bile acid biosynthesis and is itself an FXR target, embedding it in a feedback loop with sterol/bile acid metabolism.

    Evidence Adenoviral ACSL1 knockdown in mice, genome-wide expression, bile acid quantification, and FXR-KO with agonist treatment

    PMID:30580099

    Open questions at the time
    • Whether ACSL1 acts directly in bile acid synthesis or indirectly via SREBP2 not separated
  7. 2019 Medium

    Defined a metabolism-independent role for ACSL1 upstream of NF-κB in inflammatory activation of monocytes.

    Evidence Triacsin C inhibition and siRNA in THP-1/primary monocytes with NF-κB and inflammatory marker readouts; β-oxidation and ceramide inhibition as controls

    PMID:30845379

    Open questions at the time
    • The acyl-CoA species or lipid signal driving NF-κB not identified
    • Direct molecular link between acyl-CoA and NF-κB unknown
  8. 2020 High

    Established the scaffolding paradigm: unphosphorylated TBK1 anchors ACSL1 at mitochondria to favor β-oxidation, with loss of scaffolding shifting ACSL1 to the ER and re-esterification.

    Evidence Liver-specific TBK1 KO, Co-IP, fractionation, 13C tracing, and kinase-dead rescue

    PMID:33152322

    Open questions at the time
    • Structural basis of the TBK1–ACSL1 interaction not resolved
    • How fasting state controls TBK1 phosphorylation/ACSL1 binding incompletely mapped
  9. 2020 Medium

    Connected ACSL1 to protein N-myristoylation, revealing a non-classical output of its acyl-CoA synthesis in driving cancer metastasis.

    Evidence Proteomics, gain/loss-of-function, lipidomics, myristoylation assay, AMPK/Src readouts in ovarian cancer cells

    PMID:33082557

    Open questions at the time
    • Specific myristoylated substrates beyond pathway-level readouts limited at this stage
  10. 2021 High

    Defined ACSL1 as a driver of ferroptosis by incorporating PUFAs into triacylglycerols that fuel lipid peroxidation, distinguishing this from GPX4-axis ferroptosis.

    Evidence Genetic loss-of-function, lipidomics, lipid peroxidation assays, and TG-biosynthesis pharmacologic epistasis across cell types and a tumor model

    PMID:33854057

    Open questions at the time
    • How TG-stored PUFAs are mobilized for peroxidation not detailed
  11. 2021 High

    Mapped the N-terminal 100 residues as the CPT1b-binding mitochondrial targeting determinant required for ACSL1-supported FAO.

    Evidence N-terminal deletion mutagenesis, Co-IP with CPT1b, confocal localization, and Seahorse FAO assays in C2C12 myotubes

    PMID:34511469

    Open questions at the time
    • Whether CPT1b binding is required in tissues other than muscle unknown
  12. 2021 High

    Demonstrated ACSL1 is essential for ω-O-acylceramide synthesis and the skin barrier by activating linoleate, explaining its requirement for viability.

    Evidence Systemic Acsl1 KO mice with ceramide/TG lipidomics and epidermal immunofluorescence

    PMID:34813948

    Open questions at the time
    • Relative contributions of barrier defect vs other functions to embryonic lethality not dissected
  13. 2022 Medium

    Implicated ACSL1 as a brake on cardiomyocyte cell-cycle re-entry, linking its loss to myocardial regeneration via AKT/FOXO1.

    Evidence AAV9 knockdown in mice, cell-cycle analysis, AKT/FOXO1 Western blot, and post-MI cardiac function assessment

    PMID:35122795

    Open questions at the time
    • Metabolic vs signaling basis of the cell-cycle effect not separated
  14. 2023 Medium

    Extended the inflammatory role of ACSL1 to MMP-9 and macrophage foaming, defining JNK/ERK/NF-κB and CD36-FABP4-p38-PPARδ axes downstream.

    Evidence Triacsin C and siRNA in monocytes with pathway phosphorylation, reporter assays, and in vivo oral inhibitor in high-fat-fed mice

    PMID:34299302 PMID:37416456 PMID:37658104

    Open questions at the time
    • Direct acyl-CoA-derived signal initiating MAPK/NF-κB not identified
  15. 2023 Medium

    Identified FSP1 as a myristoylation substrate stabilized by ACSL1, explaining how ACSL1 can confer ferroptosis resistance in addition to driving it.

    Evidence ACSL1 gain/loss-of-function with FSP1 stability, localization, and N-myristoylation assays in ovarian cancer cells

    PMID:36882396

    Open questions at the time
    • Reconciliation of pro- vs anti-ferroptotic ACSL1 roles context-dependent and not unified mechanistically
  16. 2023 Medium

    Expanded the transcriptional control of ACSL1 to glucose (CHREBP) and inflammatory (NF-κB) inputs and additional oncogenic coactivators.

    Evidence ChIP and reporter assays for CHREBP/p65 in BMDMs; ChIP for HBXIP/Sp1 at the ACSL1 promoter in breast cancer cells

    PMID:28132807 PMID:36054206

    Open questions at the time
    • Combinatorial regulation by these factors under physiological conditions not integrated
  17. 2024 High

    Revealed MCL-1 as a direct ACSL1 partner via a non-canonical BH3 interaction selectively required for long-chain FAO, coupling an anti-apoptotic protein to mitochondrial metabolism.

    Evidence Reciprocal Co-IP, BH3 mutagenesis, Mcl1 conditional KO, BH3-mimetic inhibitors, and Seahorse FAO across cells and tissues

    PMID:38503284

    Open questions at the time
    • Structural detail of how the BH3 interaction promotes FAO not fully defined
  18. 2024 High

    Defined sortilin-mediated endolysosomal degradation as a route controlling mitochondrial ACSL1 abundance and systemic metabolic phenotype.

    Evidence Sort1 KO/knockdown in adipocytes and mice, fractionation, co-localization, AMPK/PGC1α assays, and HFD metabolic phenotyping

    PMID:39232011

    Open questions at the time
    • Signal triggering sortilin-dependent ACSL1 trafficking unknown
  19. 2024 Medium

    Added epigenetic and PRMT-axis control of ACSL1 transcription that tunes ferroptosis sensitivity across disease contexts.

    Evidence PRMT1 inhibitor/KO with H4R3me2a ChIP-seq and ACSL1-KO epistasis in AML; PRMT6/STAT1 in diabetic nephropathy; PRMT7/HMGB2 ChIP cascade in pancreatitis

    PMID:37144835 PMID:38376246 PMID:39134684

    Open questions at the time
    • Whether these PRMT axes converge on shared promoter elements not established
    • Mostly single-lab, disease-specific observations
  20. 2025 Medium

    Provided a structural-allosteric mechanism, showing ergosterol binds an ASLD1 pocket to stabilize ACSL1's closed conformation and sustain activity and mitochondrial FAO.

    Evidence In vitro binding/conformational analysis, sterol structure-activity relationships, and cellular FAO assays

    PMID:39799570

    Open questions at the time
    • Atomic-resolution structure of the binding pocket limited
    • Physiological sterol ligand in mammalian cells not confirmed
  21. 2025 Medium

    Showed metabolic state controls ACSL1 ER-targeting: acetyl-CoA accumulation (from impaired ketogenesis) and microglial TBK1 activation redirect ACSL1 to the ER for re-esterification and lipid droplet biogenesis in disease.

    Evidence HMGCS2-KO mice with fractionation and L-carnitine rescue and human MASH samples; snRNA-seq, Nrdp1 ubiquitination, NF-κB ChIP, and lipid droplet assays in PD microglia

    PMID:40684214 PMID:40692014

    Open questions at the time
    • How acetyl-CoA and TBK1 phosphorylation state mechanistically converge on ACSL1 trafficking not unified
    • Single-lab disease models

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular switch that integrates scaffolding (TBK1, CPT1b, MCL-1), degradation (sortilin), metabolite sensing (acetyl-CoA, sterols), and post-translational state to set ACSL1's mitochondria-vs-ER partitioning remains unresolved.
  • No unified model or structure of the targeting determinants
  • How a single enzyme is partitioned in real time between competing organelles is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 2 GO:0016874 ligase activity 2 GO:0008289 lipid binding 1
Localization
GO:0005739 mitochondrion 4 GO:0005783 endoplasmic reticulum 3 GO:0005811 lipid droplet 1
Pathway
R-HSA-168256 Immune System 4 R-HSA-1430728 Metabolism 3 R-HSA-5357801 Programmed Cell Death 2
Partners
CPT1BMCL1SLC27A2SORT1TBK1

Evidence

Reading pass · 30 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 Rat ACSL1 (ACS1) is an acyl-CoA synthetase that activates long-chain fatty acids (C10–C18 saturated; palmitoleate, oleate, linoleate preferred among unsaturated) to acyl-CoA thioesters. Purified recombinant enzyme showed specific activity of 26.2 µmol/min/mg. Deletion mutagenesis of five structural regions (NH2-terminus, two luciferase-like regions, linker, COOH-terminus) showed all five regions are required for enzymatic activity. Recombinant protein overexpression in E. coli, purification to homogeneity, in vitro enzymatic assay, deletion mutagenesis European journal of biochemistry High 8973631
2000 Purified recombinant rat ACSL1 (ACS1) efficiently catalyzes thioesterification of 2-arylpropionic acid NSAIDs (ibuprofen, fenoprofen), with marked stereoselectivity for the (-)R-enantiomers, identifying ACSL1 as the major enzyme responsible for the first step of chiral inversion of these drugs in liver. Recombinant ACS1 overexpressed in E. coli, purified to homogeneity, in vitro Michaelis-Menten kinetic assays with R- and S-enantiomers Drug metabolism and disposition High 10725307
1992 The human ACSL1 gene (FACL1) was chromosomally localized to region 3q13 by in situ hybridization. In situ hybridization on human chromosomes Cytogenetics and cell genetics Medium 1531127
2011 Overexpressed ACSL1 localizes to mitochondria (not plasma membrane) in both HuH7 and HepG2 hepatoma cells as shown by confocal double immunofluorescence and subcellular fractionation, and its overexpression increases acyl-CoA synthetase activity and long-chain fatty acid ([3H]-oleic acid and Bodipy-C12) uptake, suggesting metabolic trapping as the mechanism driving FA uptake. Confocal immunofluorescence with organelle markers, subcellular fractionation, enzymatic activity assay, radiolabeled and fluorescent fatty acid uptake assay in overexpressing cells International journal of medical sciences Medium 22022213
2012 Overexpressed ACSL1 localizes to mitochondria (not plasma membrane) in 3T3-L1 adipocytes as confirmed by confocal microscopy and subcellular fractionation, and increases fatty acid uptake by an indirect metabolic trapping mechanism rather than direct transport at the plasma membrane. Retroviral stable overexpression in 3T3-L1 adipocytes, confocal microscopy, subcellular fractionation, acyl-CoA synthetase activity assay, fluorescent fatty acid uptake assay PloS one Medium 23024797
2010 ACSL1 (along with FATP1) is required for AMPK activation by adiponectin and insulin in mouse adipocytes. Knockdown of Acsl1 blunted the ~2-fold rise in AMP/ATP ratio and AMPK phosphorylation triggered by adiponectin, and also reduced stimulated long-chain fatty acid uptake, placing ACSL1 activity upstream of AMP generation that activates AMPK. siRNA knockdown in 3T3-L1 adipocytes, AMP/ATP ratio measurement, AMPK phosphorylation by Western blot, radiolabeled fatty acid uptake assay FASEB journal Medium 20667975
2020 TBK1 acts as a scaffolding protein to localize ACSL1 to mitochondria, promoting acyl-CoA generation channeled to β-oxidation. Unphosphorylated (inactive) TBK1 during fasting binds ACSL1 with high affinity at mitochondria; in TBK1-deficient liver, ACSL1 shifts to the ER, redirecting fatty acids from oxidation toward re-esterification and causing hepatic lipid accumulation. Kinase-dead TBK1 rescues fatty acid oxidation, confirming the scaffolding (non-kinase) role. Liver-specific TBK1 knockout mice, Co-immunoprecipitation of TBK1–ACSL1 complex, subcellular fractionation, fatty acid oxidation assay, rescue with kinase-dead TBK1 expression, isotope tracing (13C) Cell metabolism High 33152322
2021 ACSL1 mediates ferroptotic cell death triggered by conjugated linolenic acid αESA by promoting its incorporation into neutral lipids including triacylglycerols. ACSL1 loss-of-function suppressed αESA-induced lipid peroxidation and ferroptosis; interference with triacylglycerol biosynthesis suppressed αESA-triggered (but not GPX4 inhibitor-triggered) ferroptosis. Genetic knockdown/knockout of ACSL1, lipidomics, lipid peroxidation assays, cell viability assays, pharmacologic inhibition of TG biosynthesis in diverse cancer cell types and mouse tumor model Nature communications High 33854057
2021 ACSL1 localizes to the outer mitochondrial membrane via interaction of its N-terminal 100 amino acids with CPT1b in C2C12 myotubes. An N-terminal deletion mutant (Δ1-100) failed to localize to mitochondria and did not increase fatty acid oxidation, whereas wild-type ACSL1 overexpression increased FAO rates and ameliorated palmitate-induced insulin resistance. N-terminal deletion mutagenesis, co-immunoprecipitation of ACSL1 with CPT1b, confocal microscopy for localization, Seahorse fatty acid oxidation assay, insulin signaling assay in C2C12 myotubes Molecules and cells High 34511469
2016 SREBP2 directly activates transcription of the C-ACSL1 transcript variant through a sterol regulatory element (SRE) motif in the ACSL1 C-promoter. Demonstrated by promoter-activity assays with mutated SRE, DNA-binding assays, and SREBP2 knockdown reducing ACSL1 mRNA and protein. Rosuvastatin-induced SREBP2 activation increased hepatic acyl-CoA synthetase activity and changed cholesterol ester/free cholesterol distribution. Promoter-luciferase reporter assay with SRE site mutagenesis, EMSA/DNA-binding assay, siRNA knockdown of SREBP2 in HepG2, in vivo rosuvastatin and high-cholesterol/fat diet mouse/hamster models The Journal of biological chemistry High 26728456
2018 Hepatic ACSL1 is required for bile acid biosynthesis: adenovirus-mediated ACSL1 knockdown in mice caused hypercholesterolemia with elevated LDL-C, suppressed SREBP2 pathway and LDL receptor, and reduced liver bile acid levels with altered bile acid composition. Furthermore, ACSL1 is a transcriptional target of the farnesoid X receptor (FXR); FXR agonist obeticholic acid repressed ACSL1 in wild-type but not FXR-knockout mice. Adenoviral shRNA knockdown of ACSL1 in mice (HFD and normal chow), genome-wide gene expression profiling, lipid and bile acid quantification, FXR knockout mouse model with FXR agonist treatment Biochimica et biophysica acta. Molecular and cell biology of lipids High 30580099
2024 MCL-1 binds to ACSL1 via ACSL1's non-conventional BH3-domain interacting with MCL-1's BH3-binding hydrophobic groove. This interaction supports long-chain (but not short-chain) fatty acid β-oxidation in cells, mouse livers, and hearts. Genetic loss of Mcl1, BH3 mutagenesis, or selective BH3-mimetic MCL-1 inhibitors all repressed long-chain FAO, linking MCL-1's anti-apoptotic groove to mitochondrial metabolism. Co-immunoprecipitation of MCL-1–ACSL1 complex, BH3-domain mutagenesis, Mcl1 conditional knockout in mice, BH3-mimetic inhibitor treatment, Seahorse fatty acid oxidation assays in cells, mouse liver and heart tissues Molecular cell High 38503284
2024 Sortilin (encoded by Sort1) facilitates translocation of mitochondrial ACSL1 to the endolysosomal pathway for degradation in adipocytes, thereby reducing ACSL1-mediated fatty acid β-oxidation. Sortilin depletion in adipocytes increases mitochondrial ACSL1 abundance, activates AMPK/PGC1α signaling, promotes beige fat activation, and prevents HFD-induced obesity and insulin resistance in mice. Sort1 knockout/knockdown in adipocytes and mice, subcellular fractionation, Western blot for mitochondrial ACSL1, co-localization microscopy, AMPK/PGC1α signaling assays, metabolic phenotyping of HFD mice Nature communications High 39232011
2021 Acsl1 knockout in mice causes severe skin barrier defects and embryonic lethality. Acsl1 deficiency markedly reduces ω-O-acylceramide (Cer[EOS]) synthesis by failing to activate linoleic acid for ω-O-esterification of ceramide precursors, while Cer[OS] (the precursor) accumulates. Triglyceride species containing linoleic acid are also reduced, implicating TG as a reservoir for linoleic acid channeled by Acsl1 into Cer[EOS] biosynthesis. Systemic Acsl1 knockout mice, ceramide and triglyceride lipidomics, immunofluorescence for Acsl1 expression in epidermis Biochimica et biophysica acta. Molecular and cell biology of lipids High 34813948
2020 ACSL1 promotes ovarian cancer metastasis by increasing protein N-myristoylation of substrates (via increased myristic acid activation), activating AMP-activated protein kinase and Src signaling pathways, and enhancing fatty acid β-oxidation. Shotgun proteomics comparing metastatic vs non-metastatic cells, ACSL1 overexpression/knockdown, lipidomics, AMPK and Src pathway western blotting, myristoylation assay Oncogene Medium 33082557
2023 ACSL1 increases N-myristoylation of ferroptosis suppressor protein 1 (FSP1), inhibiting FSP1 degradation and promoting its translocation to the cell membrane, thereby increasing cellular antioxidant capacity and resistance to ferroptosis in ovarian cancer cells. Genetic manipulation of ACSL1 (overexpression/knockdown), lipid oxidation assays (4-HNE), FSP1 protein stability and localization assays, N-myristoylation detection, ferroptosis resistance assays Cell death discovery Medium 36882396
2019 TNFα-induced pro-inflammatory phenotypic shift in monocytes (CD16, CD11b, CD11c, HLA-DR upregulation; IL-1β, MCP-1 secretion) requires ACSL1 activity and acts upstream of NF-κB activation. ACSL1 inhibition (triacsin C) or siRNA knockdown blocked TNFα-induced NF-κB phosphorylation and inflammatory marker expression; β-oxidation and ceramide biosynthesis inhibition had no such effect. Pharmacological ACSL1 inhibition (triacsin C), siRNA knockdown in THP-1 monocytes and primary human monocytes, flow cytometry, ELISA, NF-κB reporter assay, Western blot for NF-κB phosphorylation Cellular physiology and biochemistry Medium 30845379
2023 TNFα-mediated MMP-9 expression and secretion in monocytic cells requires ACSL1, acting through the JNK/ERK/NF-κB signaling axis. ACSL1 inhibition or knockdown reduced TNFα-induced phosphorylation of SAPK/JNK, c-Jun, ERK1/2, and NF-κB p65, and NF-κB/AP-1 reporter activity. β-oxidation and ceramide biosynthesis inhibition did not affect MMP-9. Triacsin C pharmacological inhibition, siRNA knockdown of ACSL1 in THP-1 and primary monocytes, qRT-PCR, ELISA, Western blot for pathway phosphorylation, NF-κB/AP-1 reporter assay Scientific reports Medium 37658104
2023 ACSL1 promotes foamy/inflammatory macrophage phenotype via the CD36-FABP4-p38-PPARδ signaling axis. Palmitate-induced ACSL1 upregulation drives macrophage foaming and inflammation; ACSL1 inhibition or knockdown suppressed this phenotype by downregulating FABP4 expression. In vivo, oral triacsin-C administration normalized the inflammatory/foamy monocyte phenotype under acute high-fat feeding. Pharmacological ACSL1 inhibition (triacsin C), siRNA knockdown in THP-1 and primary human monocytes, flow cytometry, ELISA, Western blot, in vivo oral triacsin-C in mice with acute HFF iScience Medium 37416456
2022 ACSL1 transcription in macrophages is induced by high glucose via the carbohydrate response element binding protein (CHREBP) and by LPS-induced inflammation via NF-κB (p65/RELA). Both transcription factors occupy the Acsl1 promoter in BMDMs and increase Acsl1 promoter reporter activity. LPS also increases ACSL1 protein localization to membranes. Acsl1 reporter gene (promoter + upstream region) assays, ChIP for CHREBP and p65 binding to Acsl1 promoter in mouse BMDMs, siRNA knockdown, Western blot, RT-PCR in primary human monocytes PloS one Medium 36054206
2017 Oncoproteins HBXIP upregulates ACSL1 transcription in breast cancer cells by acting as a coactivator with transcription factor Sp1, which binds the ACSL1 promoter. ChIP assays confirmed HBXIP–Sp1 occupancy at the ACSL1 promoter; HBXIP knockdown reduced ACSL1 mRNA and protein. ChIP assay for HBXIP/Sp1 at ACSL1 promoter, siRNA knockdown of HBXIP, overexpression of HBXIP, RT-PCR, Western blot, immunohistochemistry in clinical breast cancer tissues Biochemical and biophysical research communications Medium 28132807
2023 PRMT1 inhibition (GSK3368715) or PRMT1 knockout upregulates ACSL1 expression to promote ferroptosis sensitivity in AML cells. Mechanistically, PRMT1 controls H4R3me2a abundance at the ACSL1 promoter; GSK3368715 reduced H4R3me2a genome-wide and at the ACSL1 promoter, increasing ACSL1 expression. ACSL1 knockout reversed the ferroptosis sensitization caused by PRMT1 inhibition. PRMT1 inhibitor treatment, PRMT1 CRISPR knockout, ACSL1 CRISPR knockout, histone ChIP-seq for H4R3me2a, lipid peroxidation and ferroptosis assays in vitro and in vivo Molecular carcinogenesis Medium 37144835
2024 PRMT6 interacts with STAT1 to co-regulate ACSL1 transcription. PRMT6 reduction leads to ACSL1 upregulation and increased lipid peroxidation/ferroptosis in diabetic nephropathy. PRMT6 knockout mice showed increased renal ferroptosis that was reduced by the STAT1 inhibitor fludarabine, placing PRMT6/STAT1 upstream of ACSL1 transcription. PRMT6 knockout mice (DN model), transcriptomic and lipidomic analyses, molecular biology assays for STAT1–PRMT6 interaction and ACSL1 transcription regulation, pharmacological STAT1 inhibition Cell death and differentiation Medium 39134684
2024 PRMT7 catalyzes H4R3me1 at the HMGB2 promoter, enhancing HMGB2 transcription; HMGB2 then directly binds the ACSL1 promoter to activate ACSL1 transcription, inducing ferroptosis in pancreatic acinar cells during severe acute pancreatitis. PRMT7 inhibition alleviated ferroptosis by suppressing the HMGB2-ACSL1 pathway. PRMT7 overexpression/inhibition in AR42J cells and SAP mouse model, ChIP for H4R3me1 at HMGB2 promoter and HMGB2 binding at ACSL1 promoter, ferroptosis assays, lipid peroxidation measurement Journal of proteome research Medium 38376246
2025 Ergosterol directly binds to ACSL1, targeting a drug-binding pocket in the acetyl-CoA synthetase-like domain 1 (ASLD1) and stabilizing the closed conformation of ACSL1's C-terminal domain, allosterically maintaining enzymatic activity. Ergosterol is enriched in mitochondria and promotes fatty acid β-oxidation through this ACSL1 allosteric activation mechanism. In vitro binding/structural studies (conformational change analysis), structure-activity relationship analysis of sterols vs ACSL1 and SCAP, cellular fatty acid β-oxidation assays, mitochondrial enrichment assay Cell reports Medium 39799570
2025 In Parkinson's disease microglia, activated TBK1 promotes ACSL1 enrichment on the ER (opposite to its hepatic fasting role), where ACSL1 generates acyl-CoA channeled into lipid droplet biogenesis. ACSL1 overexpression also promotes TBK1 K63-ubiquitination via Nrdp1, creating a feedforward loop. NF-κB directly binds the ACSL1 promoter to drive transcription in microglia. Single-nucleus RNA-seq, gain/loss-of-function experiments, TBK1 activation studies, Nrdp1 ubiquitination assay, ChIP for NF-κB at ACSL1 promoter, lipid droplet quantification, dopaminergic neuron death assay Journal of neuroinflammation Medium 40684214
2025 Impaired hepatic ketogenesis (via HMGCS2 loss) causes excess acetyl-CoA accumulation that drives ACSL1 translocation to the ER, where ACSL1-mediated fatty acid re-esterification promotes hepatic steatosis. L-carnitine, which buffers acetyl-CoA, reduces ER-associated ACSL1 and alleviates steatosis. Liver-specific HMGCS2 knockout mice, Western blot for ACSL1 subcellular fractionation (ER vs mitochondria), L-carnitine rescue experiment, human primary hepatocytes, histologic analysis of human MASH samples Cellular and molecular gastroenterology and hepatology Medium 40692014
2023 FATP2 (SLC27A2) physically interacts with ACSL1 in non-small cell lung cancer cells, as shown by Co-IP. Co-transfection of si-FATP2 with pcDNA-ACSL1 further inhibited proliferation and lipid deposition and promoted fatty acid decomposition, indicating FATP2 regulates lipid metabolism through ACSL1. Co-immunoprecipitation (FATP2–ACSL1 interaction), siRNA knockdown of FATP2, ACSL1 overexpression, cell proliferation and lipid deposition assays Tissue & cell Low 37172427
2022 ACSL1 knockdown in neonatal mouse cardiomyocytes and via AAV9 in adult mice promoted cell cycle progression from G0 to G2 phase, enhanced myocardial regeneration, and improved cardiac function after MI, associated with AKT activation and FOXO1 nuclear exclusion. AAV9-mediated ACSL1 knockdown in mice, primary cardiomyocyte culture, cell cycle analysis, AKT/FOXO1 pathway Western blot, cardiac function assessment (echocardiography), myocardial infarction model Life sciences Medium 35122795
2021 ACSL1 inhibition (triacsin C) or knockdown suppressed acetate-plus-TNFα-synergized MCP-1 production in monocytes through the ACSL1/MAPK/NF-κB axis; ACSL1 inhibition reduced p38 MAPK, ERK1/2, and NF-κB phosphorylation and NF-κB/AP-1 activity. Neither CPT-I nor SPT inhibition recapitulated this effect, placing acyl-CoA formation specifically upstream. Pharmacological ACSL1 inhibition, siRNA knockdown in THP-1 monocytes, ELISA, qRT-PCR, Western blot for MAPK/NF-κB pathway phosphorylation, NF-κB/AP-1 reporter assay International journal of molecular sciences Medium 34299302

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nature communications 212 33854057
2008 ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation. The Journal of nutrition 183 18492828
2020 TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Cell metabolism 107 33152322
2011 Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. International journal of medical sciences 103 22022213
2014 MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA. Biochemical and biophysical research communications 97 24462768
2011 The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. The FEBS journal 94 21366874
2011 Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus. Proceedings of the National Academy of Sciences of the United States of America 79 22006318
2023 ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability. Cell death discovery 76 36882396
2012 Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes. PloS one 71 23024797
1997 Transcriptional control of the yeast acetyl-CoA synthetase gene, ACS1, by the positive regulators CAT8 and ADR1 and the pleiotropic repressor UME6. Molecular microbiology 68 9427394
2020 ACSL1 affects Triglyceride Levels through the PPARγ Pathway. International journal of medical sciences 65 32218693
1996 Biochemical studies of two rat acyl-CoA synthetases, ACS1 and ACS2. European journal of biochemistry 64 8973631
2010 Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 62 20667975
2023 TNFα induces matrix metalloproteinase-9 expression in monocytic cells through ACSL1/JNK/ERK/NF-kB signaling pathways. Scientific reports 61 37658104
2020 Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation. Oncogene 53 33082557
2017 Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling. Biochemical and biophysical research communications 52 28359761
2010 Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. Journal of lipid research 52 20176858
2016 MicroRNA Bta-miR-181a regulates the biosynthesis of bovine milk fat by targeting ACSL1. Journal of dairy science 50 26971144
2015 ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content. Molecular endocrinology (Baltimore, Md.) 49 25915184
1995 Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACS1 from Saccharomyces cerevisiae. Gene 49 7642141
2017 HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer. Biochemical and biophysical research communications 46 28132807
1999 An allele of the ripening-specific 1-aminocyclopropane-1-carboxylic acid synthase gene (ACS1) in apple fruit with a long storage life. Plant physiology 46 10198088
2024 Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1. Molecular cell 43 38503284
1997 The Saccharomyces cerevisiae acetyl-coenzyme A synthetase encoded by the ACS1 gene, but not the ACS2-encoded enzyme, is subject to glucose catabolite inactivation. FEMS microbiology letters 43 9252575
2023 PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. Molecular carcinogenesis 42 37144835
2020 Effects of overexpression of ACSL1 gene on the synthesis of unsaturated fatty acids in adipocytes of bovine. Archives of biochemistry and biophysics 42 33098867
2019 TNF-α Induces a Pro-Inflammatory Phenotypic Shift in Monocytes through ACSL1: Relevance to Metabolic Inflammation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 41 30845379
2020 Methyl Jasmonate Enhances Ethylene Synthesis in Kiwifruit by Inducing NAC Genes That Activate ACS1. Journal of agricultural and food chemistry 40 32101430
2024 The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy. Cell death and differentiation 39 39134684
2011 Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle. BMC genetics 39 22078495
2021 Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. Viruses 38 34960652
2016 SREBP2 Activation Induces Hepatic Long-chain Acyl-CoA Synthetase 1 (ACSL1) Expression in Vivo and in Vitro through a Sterol Regulatory Element (SRE) Motif of the ACSL1 C-promoter. The Journal of biological chemistry 36 26728456
2006 The involvement of 1-aminocyclopropane-1-carboxylic acid synthase isogene, Pp-ACS1, in peach fruit softening. Journal of experimental botany 36 16531466
2019 ACSL1 Regulates TNFα-Induced GM-CSF Production by Breast Cancer MDA-MB-231 Cells. Biomolecules 35 31581558
2023 RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4. Oncogene 34 38040804
2022 Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration. Life sciences 33 35122795
2015 MicroRNA-34a Promotes Hepatic Stellate Cell Activation via Targeting ACSL1. Medical science monitor : international medical journal of experimental and clinical research 33 26437572
1999 acs1 of Haemophilus influenzae type a capsulation locus region II encodes a bifunctional ribulose 5-phosphate reductase- CDP-ribitol pyrophosphorylase. Journal of bacteriology 31 10094675
2020 The function of SNHG7/miR-449a/ACSL1 axis in thyroid cancer. Journal of cellular biochemistry 30 31961004
2019 The inhibition of Nrf2 accelerates renal lipid deposition through suppressing the ACSL1 expression in obesity-related nephropathy. Renal failure 30 31488013
2007 Molecular characterisation of Lac s 1, the major allergen from lettuce (Lactuca sativa). Molecular immunology 30 17349693
2008 Characterization of transcriptional profiles of MA-ACS1 and MA-ACO1 genes in response to ethylene, auxin, wounding, cold and different photoperiods during ripening in banana fruit. Journal of plant physiology 28 18554749
2004 Inheritance of the Md-ACS1 gene and its relationship to fruit softening in apple ( Malus x domestica Borkh.). TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 27 14968302
2023 ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat feeding. iScience 26 37416456
2021 ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway. Frontiers in immunology 26 34777393
2024 The Diagnostic Value of ACSL1, ACSL4, and ACSL5 and the Clinical Potential of an ACSL Inhibitor in Non-Small-Cell Lung Cancer. Cancers 25 38539505
2021 Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis. International journal of molecular sciences 24 34299302
2015 Regulation of Acetate Metabolism and Acetyl Co-a Synthetase 1 (ACS1) Expression by Methanol Expression Regulator 1 (Mxr1p) in the Methylotrophic Yeast Pichia pastoris. The Journal of biological chemistry 22 26663080
2023 CircDOCK7 facilitates the proliferation and adipogenic differentiation of chicken abdominal preadipocytes through the gga-miR-301b-3p/ACSL1 axis. Journal of animal science and biotechnology 21 37408086
2018 Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor. Biochimica et biophysica acta. Molecular and cell biology of lipids 20 30580099
2005 RP-ACS1, a flooding-induced 1-aminocyclopropane-1-carboxylate synthase gene of Rumex palustris, is involved in rhythmic ethylene production. Journal of experimental botany 20 15642709
1996 The lactose transporter in Leuconostoc lactis is a new member of the LacS subfamily of galactoside-pentose-hexuronide translocators. Applied and environmental microbiology 20 8633855
2025 Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1. Cell reports 19 39799570
2015 Age-related difference in the sleep pressure-lowering effect between an angiotensin II receptor blocker and a calcium channel blocker in Asian hypertensives: the ACS1 Study. Hypertension (Dallas, Tex. : 1979) 19 25646296
2025 ACSL1 Aggravates Thromboinflammation by LPC/LPA Metabolic Axis in Hyperlipidemia Associated Myocardial Ischemia-Reperfusion Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 18 39853712
2024 Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice. Nature communications 17 39232011
2022 ACSL1 promotes imatinib-induced chronic myeloid leukemia cell senescence by regulating SIRT1/p53/p21 pathway. Scientific reports 17 36289272
2012 Expression and genome polymorphism of ACSL1 gene in different pig breeds. Molecular biology reports 17 22714915
2021 MiR-34c promotes hepatic stellate cell activation and Liver Fibrogenesis by suppressing ACSL1 expression. International journal of medical sciences 16 33437196
2021 An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes. Molecules and cells 16 34511469
2004 The role of cis-acting sequences governing catabolite repression control of lacS expression in the archaeon Sulfolobus solfataricus. Genetics 16 15342498
2000 Thioesterification of 2-arylpropionic acids by recombinant acyl-coenzyme A synthetases (ACS1 and ACS2). Drug metabolism and disposition: the biological fate of chemicals 16 10725307
2024 ACSL1-Mediated Fatty Acid β-Oxidation Enhances Metastasis and Proliferation in Endometrial Cancer. Frontiers in bioscience (Landmark edition) 15 38420815
2012 A Ser/Thr protein kinase phosphorylates MA-ACS1 (Musa acuminata 1-aminocyclopropane-1-carboxylic acid synthase 1) during banana fruit ripening. Planta 15 22419220
2025 Semaglutide Reprograms Macrophages via the GLP-1R/PPARG/ACSL1 Pathway to Suppress Papillary Thyroid Carcinoma Growth. The Journal of clinical endocrinology and metabolism 14 39908200
2023 ACSL1, CH25H, GPCPD1, and PLA2G12A as the potential lipid-related diagnostic biomarkers of acute myocardial infarction. Aging 14 36863716
2023 FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1. Tissue & cell 14 37172427
2022 MiR-218-5p Affects Subcutaneous Adipogenesis by Targeting ACSL1, a Novel Candidate for Pig Fat Deposition. Genes 14 35205304
2022 Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation. PloS one 14 36054206
2019 Ethylene Response of Plum ACC Synthase 1 (ACS1) Promoter is Mediated through the Binding Site of Abscisic Acid Insensitive 5 (ABI5). Plants (Basel, Switzerland) 14 31052513
2005 The doubly phosphorylated form of HPr, HPr(Ser~P)(His-P), is abundant in exponentially growing cells of Streptococcus thermophilus and phosphorylates the lactose transporter LacS as efficiently as HPr(His~P). Applied and environmental microbiology 14 15746339
2024 ACSL1 improves pulmonary fibrosis by reducing mitochondrial damage and activating PINK1/Parkin mediated mitophagy. Scientific reports 13 39489819
2019 The Molecular Characteristics of the FAM13A Gene and the Role of Transcription Factors ACSL1 and ASCL2 in Its Core Promoter Region. Genes 13 31795267
2003 Phosphorylation of Streptococcus salivarius lactose permease (LacS) by HPr(His ~ P) and HPr(Ser-P)(His ~ P) and effects on growth. Journal of bacteriology 13 14617640
1999 Expression characteristics of CS-ACS1, CS-ACS2 and CS-ACS3, three members of the 1-aminocyclopropane-1-carboxylate synthase gene family in cucumber (Cucumis sativus L.) fruit under carbon dioxide stress. Plant & cell physiology 13 10202812
2022 CircPDHX promotes prostate cancer cell progression in vitro and tumor growth in vivo via miR-497-5p/ACSL1 axis. Biochemical and biophysical research communications 12 35777132
2009 The 5' untranslated region of the VR-ACS1 mRNA acts as a strong translational enhancer in plants. Transgenic research 12 19816782
2025 Stevia rebaudiana root polysaccharide modulates liver metabolism, bile acid, and gut microbiota improving HFD-induced NAFLD: Potential roles of ACSL1 and FADS2. Phytomedicine : international journal of phytotherapy and phytopharmacology 11 40220428
2022 Liraglutide Exerts Protective Effects by Downregulation of PPARγ, ACSL1 and SREBP-1c in Huh7 Cell Culture Models of Non-Alcoholic Steatosis and Drug-Induced Steatosis. Current issues in molecular biology 11 36005135
2024 PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis. Journal of proteome research 10 38376246
2023 Transcriptional Regulation Associated with Subcutaneous Adipogenesis in Porcine ACSL1 Gene. Biomolecules 10 37509093
2022 Novel Insight Into the Role of ACSL1 Gene in Milk Production Traits in Buffalo. Frontiers in genetics 10 35734439
2020 Polymorphisms of the ACSL1 Gene Influence Milk Production Traits and Somatic Cell Score in Chinese Holstein Cows. Animals : an open access journal from MDPI 10 33287296
2015 Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828. Frontiers in aging neuroscience 10 25999849
2012 Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study. PloS one 10 22829935
2021 Interference with ACSL1 gene in bovine adipocytes: Transcriptome profiling of circRNA related to unsaturated fatty acid production. Genomics 9 34601049
2021 Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice. Biochimica et biophysica acta. Molecular and cell biology of lipids 9 34813948
2021 Interference With ACSL1 Gene in Bovine Adipocytes: Transcriptome Profiling of mRNA and lncRNA Related to Unsaturated Fatty Acid Synthesis. Frontiers in veterinary science 9 34977220
2006 Tissue-cell- and species-specific expression of gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in gonads, adrenal and brain. Identification of novel forms in the brain. The Journal of steroid biochemistry and molecular biology 9 16469493
2024 Polystyrene microplastics interaction and influence on the growth kinetics and metabolism of tilapia gut probiotic Bacillus tropicus ACS1. Environmental science. Processes & impacts 8 37990603
2023 Genome-Wide Analysis and Functional Characterization of LACS Gene Family Associated with Lipid Synthesis in Cotton (Gossypium spp.). International journal of molecular sciences 8 37239883
1992 Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). Cytogenetics and cell genetics 8 1531127
2025 Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer. Apoptosis : an international journal on programmed cell death 7 40095264
2025 Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson's disease. Journal of neuroinflammation 7 40684214
2018 Expression of grape ACS1 in tomato decreases ethylene and alters the balance between auxin and ethylene during shoot and root formation. Journal of plant physiology 7 29778014
2024 ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease. Nefrologia 6 38245444
2024 Platelet-Derived Microvesicles Mediate Cardiomyocyte Ferroptosis by Transferring ACSL1 During Acute Myocardial Infarction. Molecular biotechnology 6 38466505
2018 Production of microhomologous-mediated site-specific integrated LacS gene cow using TALENs. Theriogenology 6 30075414
2004 Possible involvement of CS-ACS1 and ethylene in auxin-induced peg formation of cucumber seedlings. Annals of botany 6 15585540
2025 Hepatic Ketogenesis Regulates Lipid Homeostasis via ACSL1-mediated Fatty Acid Partitioning. Cellular and molecular gastroenterology and hepatology 5 40692014

Missed literature

Know a paper Affinage missed for ACSL1? Flag it for the maintainers and the community.

No submissions yet.