Affinage

CPT1B

Carnitine O-palmitoyltransferase 1, muscle isoform · UniProt Q92523

Length
772 aa
Mass
87.8 kDa
Annotated
2026-04-28
47 papers in source corpus 24 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CPT1B is the muscle-type carnitine palmitoyltransferase I that catalyzes the rate-limiting step of mitochondrial long-chain fatty acid β-oxidation in heart and skeletal muscle by transferring acyl groups from acyl-CoA to carnitine (PMID:12015320, PMID:34330275). Its enzymatic activity is allosterically inhibited by malonyl-CoA, and a knock-in mouse expressing a malonyl-CoA–insensitive mutant (E3A) shows nearly twofold elevated cardiac fatty acid oxidation with compensatory transcriptional downregulation of FAO genes (PMID:29635338). Post-translationally, prolyl hydroxylation at P295 by PHD2/3 is required for CPT1B interaction with VDAC1 and for functional long-chain fatty acid oxidation in cardiomyocytes (PMID:34610308). CPT1B transcription is regulated by a network of activators and repressors—including MEF2A/HDAC5, EZH2-mediated H3K27me3, AR, MITF, ZNF263, and SMAD3—and in sperm mitochondria, TEX44 physically modulates CPT1B activity to limit ROS production, with germ-cell-specific Cpt1b knockout causing mitochondrial sheath defects and impaired sperm motility (PMID:25213552, PMID:31735087, PMID:40849303).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1997 High

    Establishing that human CPT1B is a distinct gene at 22qter with its own alternative splicing pattern resolved the question of how muscle-type and liver-type CPT1 isoforms are independently encoded.

    Evidence cDNA/genomic sequencing and FISH mapping of human CPT1B

    PMID:9199240

    Open questions at the time
    • Functional consequences of the intron 13 splice variant (10 aa deletion) not tested enzymatically
    • Regulatory differences between two CPT1B promoters not addressed
  2. 2002 High

    Demonstrating that CPT1B splice variants lack enzymatic activity when expressed in Pichia pastoris ruled out alternative splicing as a mechanism for modulating malonyl-CoA sensitivity, reinforcing that allosteric regulation is the primary control point.

    Evidence Heterologous expression in Pichia pastoris with enzymatic activity assay

    PMID:12015320

    Open questions at the time
    • The structural determinants of malonyl-CoA sensitivity not mapped at the residue level
    • Whether splice variants have non-enzymatic functions not tested
  3. 2014 High

    Identifying MEF2A as a direct transcriptional activator of Cpt1b whose activity is derepressed by exercise-induced HDAC5 phosphorylation and nuclear export established the first defined transcription factor–promoter mechanism for exercise-induced FAO gene upregulation in skeletal muscle.

    Evidence ChIP, luciferase promoter assay, MEF2A overexpression in C2C12 myoblasts, mouse treadmill exercise model

    PMID:25213552

    Open questions at the time
    • Whether MEF2A is sufficient for exercise-induced CPT1B upregulation or acts in combination with other factors
    • HDAC3 contribution at the CPT1B promoter not dissected independently of HDAC5
  4. 2015 High

    Showing that CpG hypermethylation at the CPT1B promoter blocks USF binding and blunts lipid-responsive CPT1B induction in obese human muscle revealed an epigenetic layer of CPT1B regulation with metabolic disease relevance.

    Evidence Bisulfite sequencing, ChIP, histone acetylation assays in primary human skeletal muscle cultures from obese vs. lean women

    PMID:26058865

    Open questions at the time
    • Whether methylation changes are cause or consequence of obesity not determined
    • Writers/erasers responsible for CPT1B promoter methylation not identified
  5. 2018 High

    The CPT1B-E3A knock-in mouse provided direct in vivo evidence that malonyl-CoA inhibition is the rate-limiting control point for cardiac FAO, as relieving this inhibition increased FAO ~1.9-fold with compensatory transcriptional feedback.

    Evidence CPT1B-E3A knock-in mice, isolated perfused heart FAO assay, multi-omics

    PMID:29635338

    Open questions at the time
    • Whether chronic loss of malonyl-CoA sensitivity causes cardiac pathology under stress conditions
    • The identity of the feedback sensor linking FAO flux to CPT1B transcription is unknown
  6. 2019 High

    EZH2-mediated H3K27me3 at the CPT1B promoter was shown to suppress CPT1B transcription during cardiac hypertrophy, establishing a Polycomb-group epigenetic silencing mechanism controlled upstream by mTORC1 and the lncRNA uc.323.

    Evidence ChIP for EZH2/H3K27me3, lncRNA microarray, gain/loss-of-function in cardiomyocytes, aortic banding mouse model

    PMID:31735087

    Open questions at the time
    • Whether EZH2 recruitment is specific to CPT1B or part of a broader FAO gene silencing program
    • Direct interaction between uc.323 and EZH2 at the CPT1B locus not confirmed by CLIP or similar
  7. 2020 Medium

    Multiple transcription factors were shown to directly bind the CPT1B promoter—AR as a repressor and miR-138-5p as a post-transcriptional silencer—expanding the regulatory network controlling CPT1B expression in contexts ranging from prostate cancer to NAFLD.

    Evidence ChIP and dual-luciferase for AR (prostate cancer cells); dual-luciferase with 3′UTR mutation for miR-138-5p (rat NAFLD model)

    PMID:32325349 PMID:32648618

    Open questions at the time
    • AR-CPT1B axis not validated in non-cancer tissues
    • Physiological relevance of miR-138-5p regulation of CPT1B outside of the NAFLD model unclear
  8. 2021 High

    Discovery that PHD2/3-mediated prolyl hydroxylation at P295 is required for CPT1B–VDAC1 interaction and functional FAO revealed a novel oxygen-sensing post-translational control of mitochondrial fatty acid import.

    Evidence Co-IP, CPT1B-P295A mutagenesis, PHD2/3 KO mice, high-fat diet rescue experiments in cardiomyocytes

    PMID:34610308

    Open questions at the time
    • Structural basis of how P295 hydroxylation promotes VDAC1 binding not resolved
    • Whether other mitochondrial outer membrane partners are regulated by this hydroxylation is unknown
  9. 2021 Medium

    Multi-omic analysis of aged skeletal muscle identified CPT1B as the specific protein whose decline under high-fat diet causes loss of metabolic flexibility, positioning it as the dominant flux controller of FAO in aging.

    Evidence Proteomics, lipidomics, mitochondrial function analysis, computational metabolic flux modeling in young vs. aged mice

    PMID:34330275

    Open questions at the time
    • Whether restoring CPT1B levels rescues metabolic flexibility in aged muscle not tested
    • Mechanism of age-specific CPT1B protein decline not defined
  10. 2022 Medium

    SMAD3 was identified as a direct CPT1B promoter-binding transcription factor downstream of myostatin signaling, linking the myostatin–SMAD3 axis to FAO regulation in skeletal muscle.

    Evidence ChIP, CPT1 enzyme activity assay, Mstn knockdown in mouse skeletal muscle

    PMID:36002433

    Open questions at the time
    • Whether SMAD3 acts as activator or repressor at the Cpt1b promoter not fully resolved
    • Contribution relative to other SMAD isoforms not addressed
  11. 2023 Medium

    MITF was identified as a transcriptional repressor of CPT1B in lung adenocarcinoma, directly linking FAO suppression to cancer stem cell stemness regulation.

    Evidence ChIP and dual-luciferase assay confirming MITF binding at CPT1B promoter, FAO and sphere-forming assays

    PMID:38016436

    Open questions at the time
    • Whether MITF regulation of CPT1B occurs in non-cancer melanocytic or muscle lineages
    • Downstream metabolic intermediates linking reduced FAO to stemness not identified
  12. 2024 Medium

    CPT1B was found to interact with KEAP1, and its knockdown reduces NRF2 and induces ferroptosis in pancreatic cancer cells, suggesting a non-canonical role in redox homeostasis beyond its enzymatic function.

    Evidence Co-immunoprecipitation, siRNA knockdown, ferroptosis markers, xenograft model

    PMID:38302326

    Open questions at the time
    • Single Co-IP without reciprocal validation or domain mapping
    • Whether KEAP1 interaction depends on CPT1B enzymatic activity or is a scaffolding role not determined
    • Relevance outside pancreatic cancer not tested
  13. 2024 Medium

    ZNF263 was identified as a transcriptional activator of CPT1B promoting cisplatin resistance through enhanced FAO in lung adenocarcinoma, demonstrating that CPT1B-driven FAO can be co-opted for drug resistance.

    Evidence ChIP and dual-luciferase at CPT1B promoter, FAO rate assay, etomoxir rescue

    PMID:39500874

    Open questions at the time
    • Whether ZNF263 regulates CPT1B in normal muscle or heart tissue
    • Specificity of ZNF263 for CPT1B versus other FAO genes not assessed
  14. 2025 High

    TEX44 was discovered to physically interact with CPT1B in sperm mitochondria, directly modulating its enzymatic activity to limit excess ROS from unregulated FAO; germ-cell-specific Cpt1b KO phenocopied TEX44 deficiency, establishing CPT1B as essential for mitochondrial sheath assembly and male fertility.

    Evidence Tex44 KO and germ-cell-specific Cpt1b KO mice, purified TEX44 protein modulating CPT1B activity in vitro, Co-IP, human patient exome sequencing

    PMID:40849303

    Open questions at the time
    • Structural basis of TEX44–CPT1B interaction not defined
    • Whether TEX44 modulation involves allosteric inhibition or substrate competition unknown
  15. 2025 Medium

    AAV-mediated cardiac CPT1B overexpression attenuated pressure-overload-induced hypertrophy and fibrosis, providing direct gain-of-function evidence that maintaining CPT1B levels is cardioprotective.

    Evidence AAV gene transfer in neonatal rat cardiomyocytes and transverse aortic constriction mouse model with echocardiography and histology

    PMID:40646338

    Open questions at the time
    • Whether cardioprotection is solely via increased FAO or involves non-enzymatic CPT1B functions
    • Long-term effects of sustained CPT1B overexpression not evaluated

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of malonyl-CoA inhibition and PHD-mediated hydroxylation effects on CPT1B conformation, how the extensive transcriptional regulatory network is integrated in a tissue- and context-specific manner, and whether non-enzymatic roles (e.g., KEAP1 interaction, scaffolding in sperm mitochondria) represent a general moonlighting function of CPT1B.
  • No high-resolution structure of full-length CPT1B with malonyl-CoA or VDAC1
  • Tissue-specific integration of multiple TF inputs not modeled
  • Non-enzymatic roles lack structural or reconstitution-level evidence

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 3
Localization
GO:0005739 mitochondrion 2
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1474165 Reproduction 1
Partners
EZH2HDAC5KEAP1MEF2ASMAD3TEX44VDAC1

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 CPT1B (muscle-type carnitine palmitoyltransferase I) encodes a key enzyme controlling beta-oxidation of long-chain fatty acids in heart and skeletal muscle; the gene has two promoters in humans, mice, sheep, and rats, and splice variants in the coding region do not produce CPT1 enzymatic activity when expressed in Pichia pastoris, arguing against splice variation as a mechanism of malonyl-CoA sensitivity modulation. cDNA/genomic sequencing, expression in Pichia pastoris (in vitro enzymatic activity assay), fluorescent in situ hybridization The Journal of biological chemistry High 12015320
1997 The human CPT1B gene maps to chromosome 22qter (distinct from the liver-type CPT1A locus), contains an untranslated 5' exon, and undergoes alternative splicing of introns 13 and 19, with intron 13 splicing causing an in-frame deletion producing a protein 10 amino acids smaller. cDNA and genomic DNA sequencing, fluorescent in situ hybridization (FISH) Biochimica et biophysica acta High 9199240
1998 Mouse Cpt1b maps to chromosome 15 (distinct from Cpt1a on chromosome 19), confirming that the liver-type and muscle-type CPT1 isoforms are encoded by different loci at separate chromosomal positions. Chromosomal mapping using mouse mapping panel, cDNA probes Mammalian genome : official journal of the International Mammalian Genome Society High 9680378
2018 Malonyl-CoA-dependent inhibition of CPT1B plays a crucial role in regulating the rate of cardiac fatty acid oxidation; a knock-in mouse expressing CPT1B-E3A (reduced malonyl-CoA sensitivity) showed 1.9-fold higher FAO in isolated perfused hearts, with compensatory downregulation of CPT1B protein and FAO gene expression. Knock-in mouse model (CPT1B-E3A mutant), isolated perfused heart FAO assay, metabolomics, proteomics, transcriptomics Cardiovascular research High 29635338
2021 PHD2/3 (prolyl hydroxylases) bind to CPT1B and promote hydroxylation of CPT1B at proline-295 (P295); this hydroxylation is required for CPT1B interaction with VDAC1 and for long-chain fatty acid beta-oxidation in cardiomyocytes. A CPT1B-P295A mutant constitutively binds VDAC1 and rescues LCFA metabolism in PHD2/3-deficient cardiomyocytes. Co-immunoprecipitation, site-directed mutagenesis (CPT1B-P295A), PHD2/3 knockout mice, high-fat diet model, rescue experiments Cell reports High 34610308
2025 TEX44 interacts with CPT1B in sperm mitochondria to form a 'mitochondrial glue' anchoring adjacent mitochondria for assembly of the sperm-specific mitochondrial sheath; purified TEX44 protein modulates CPT1B enzymatic activity, limiting conversion of long-chain fatty acids (palmitic and myristic acid) into acylcarnitines and thereby reducing ROS. Loss of TEX44 leads to unregulated FAO, excessive ROS, and sperm DNA/flagellar damage. Germ-cell-specific Cpt1b knockout mice exhibit mitochondrial sheath defects and reduced sperm motility similar to TEX44 deficiency. Whole-exome sequencing, Tex44 knockout mice, germ-cell-specific Cpt1b knockout mice, in vitro purified TEX44 protein enzymatic modulation assay, co-immunoprecipitation Nature communications High 40849303
2015 CPT1B promoter activity in skeletal muscle is regulated by epigenetic modifications: in severely obese women, blunted CPT1B expression in response to lipid is accompanied by CpG hypermethylation, reduced H3/H4 histone acetylation, and altered occupancy of PPARδ and HNF4α; methylation of specific CpG sites blocks binding of the transcription factor USF at the CPT1B promoter. Primary human skeletal muscle cultures, real-time PCR, chromatin immunoprecipitation (ChIP), bisulfite sequencing (CpG methylation), histone acetylation assays, transcription factor binding assays American journal of physiology. Endocrinology and metabolism High 26058865
2014 MEF2A binds to a specific MEF2 site in the Cpt1b promoter and activates Cpt1b transcription; exercise training increases MEF2A binding and MEF2A acetylation at the Cpt1b promoter while decreasing HDAC5 and HDAC3 binding to MEF2A and to the promoter. HDAC5 phosphorylation (Ser259/Ser498) by exercise causes its nuclear export, derepressing MEF2A-dependent Cpt1b transcription. Chromatin immunoprecipitation (ChIP), MEF2A overexpression in C2C12 myoblasts, luciferase promoter assay, mouse treadmill exercise model, Western blot Acta physiologica (Oxford, England) High 25213552
2019 EZH2 binds to the CPT1B promoter via H3K27me3 (trimethylation of lysine 27 of histone H3) to suppress CPT1B transcription during cardiac hypertrophy; the long noncoding RNA uc.323 interacts with EZH2 and its downregulation (via mTORC1) leads to reduced CPT1B expression and cardiomyocyte hypertrophy. CPT1B overexpression blocks uc.323-mediated cardiomyocyte hypertrophy. Chromatin immunoprecipitation (ChIP), lncRNA microarray, mRNA microarray, gain/loss-of-function experiments in cardiomyocytes, aortic banding mouse model Hypertension (Dallas, Tex. : 1979) High 31735087
2020 miR-138-5p directly targets the CPT1B 3'UTR to suppress its expression; miR-138-5p inhibitor increases CPT1B expression while mimic reduces it, and mutation of CPT1B abrogates this regulation. CPT1B upregulation by GJLZ decoction in NAFLD is mediated through suppression of miR-138-5p. Dual-luciferase reporter assay, miRNA mimic/inhibitor, RT-PCR, Western blot, rat NAFLD model Biomedicine & pharmacotherapy Medium 32325349
2020 Androgen receptor (AR) inhibits CPT1B transcription via specific AR-binding sites in the CPT1B promoter, confirmed by dual-luciferase assay and ChIP; in CRPC cells, CPT1B overexpression increases AKT expression and phosphorylation. Dual-luciferase assay, ChIP assay, stable knockdown/overexpression cell lines, Western blot The Prostate Medium 32648618
2022 SMAD3, a transcription factor downstream of myostatin (Mstn), directly binds to the Cpt1b promoter to regulate its transcription; Mstn knockdown upregulates Cpt1b expression and CPT1 enzyme activity in skeletal muscle, promoting beta-oxidation. Chromatin immunoprecipitation (ChIP), CPT1 enzyme activity assay, RT-PCR, RNA interference mouse model Sheng wu gong cheng xue bao = Chinese journal of biotechnology Medium 36002433
2019 In LRP6-deficient hearts, Drp1 activation leads to decreased CPT1B expression and lipid accumulation; Drp1 inhibitor restores CPT1B levels and reduces fatty acid accumulation. c-Myc (but not CTCF) is identified as a transcriptional regulator of CPT1B in cardiomyocytes. Cardiac-specific LRP6 knockout mice, GC-FID/MS fatty acid analysis, Drp1 inhibitor treatment, in vitro c-Myc overexpression/knockdown Cell and tissue research Medium 31811407
2016 Cardiac-specific knockdown of CPT1B via lentiviral injection in obese mice protected against HFD-induced cardiac remodeling, decreasing heart weight/tibial length ratio, improving ejection fraction, reducing reactive oxygen species and lipid accumulation in cardiomyocytes, and partially preserving myocardial ultrastructure. Intramyocardial lentivirus injection for CPT1B knockdown, echocardiography, histology, ROS assay, electron microscopy, biochemical assays in mouse obesity model Obesity (Silver Spring, Md.) Medium 27804274
2025 AAV-mediated cardiac overexpression of CPT1B in neonatal rat cardiomyocytes attenuated phenylephrine-induced hypertrophy and decreased mitochondrial ROS; in mice subjected to transverse aortic constriction, cardiac CPT1B overexpression attenuated cardiomyocyte hypertrophy, cardiac fibrosis, and systolic dysfunction. AAV gene transfer, neonatal rat cardiomyocyte culture, transverse aortic constriction mouse model, echocardiography, histology, ROS measurement Basic research in cardiology Medium 40646338
2024 CPT1B interacts with KEAP1 (Kelch-like ECH-associated protein 1); CPT1B knockdown leads to decreased NRF2 expression and induction of ferroptosis in pancreatic cancer cells, linking CPT1B to the KEAP1/NRF2 redox homeostasis axis. Co-immunoprecipitation, Western blot, siRNA knockdown, flow cytometry, confocal fluorescence microscopy, transmission electron microscopy, animal xenograft model Surgery Medium 38302326
2024 ZNF263 binds to the CPT1B promoter to activate its transcription, enhancing fatty acid beta-oxidation and promoting cisplatin resistance in lung adenocarcinoma cells; CPT1B-mediated resistance is abrogated by FAO inhibitor etomoxir. Dual-luciferase assay, chromatin immunoprecipitation (ChIP), qRT-PCR, Western blot, CCK-8, FAO rate assay The pharmacogenomics journal Medium 39500874
2023 MITF (microphthalmia-associated transcription factor) binds the CPT1B promoter and inhibits CPT1B transcription, reducing fatty acid beta-oxidation and suppressing cancer stem cell stemness in lung adenocarcinoma cells. Dual-luciferase assay, ChIP assay, qRT-PCR, FAO assay, sphere-forming assay Pharmacology Medium 38016436
2021 ANXA1 (Annexin A1) regulates CPT1B expression via the FPR2/ALX-AMPK-PPARα signaling axis in proximal tubular epithelial cells; ANXA1 silencing suppresses phosphorylated AMPK (Thr172), leading to decreased PPARα and CPT1B expression and increased lipid accumulation. siRNA knockdown, Western blot, lipid accumulation assay, phospho-AMPK assay, high-glucose/palmitate treatment of human PTECs Diabetes Medium 34103347
2021 In aged skeletal muscle, CPT1B protein specifically declines under high-fat diet conditions while other beta-oxidation proteins are upregulated, and computational flux modeling identifies CPT1B as the primary controller of FAO flux, causing loss of metabolic flexibility and contributing to insulin resistance. Proteomics, lipidomics, mitochondrial function analysis, computational metabolic flux modeling in young vs. aged mice on low-fat or high-fat diet BMC biology Medium 34330275
2024 STAT3 directly binds to the CPT1B promoter/gene region in pancreatic cancer stem cells, regulating CPT1B expression and thereby affecting lipid/energy metabolism; quercetin inhibits CPT1B via STAT3 suppression. Chromatin immunoprecipitation (ChIP), qRT-PCR, Western blot, siRNA/overexpression of STAT3 Biochemical and biophysical research communications Low 40412371
2013 CB1 (cannabinoid receptor 1) regulates CPT1B mRNA expression in porcine intramuscular adipocytes; CB1 agonist Δ9-THC decreases CPT1B expression and increases lipid accumulation, while the CB1 antagonist SR141716 increases CPT1B expression and reduces lipid accumulation. CB1 is upstream of CPT1B; CPT1 antagonist etomoxir does not affect CB1 expression. Pharmacological treatment (Δ9-THC and SR141716), RT-PCR, lipid accumulation assay in porcine intramuscular adipocytes Animal genetics Low 23914904
2024 cpt1b regulates cardiomyocyte proliferation in zebrafish; cpt1b knockout impairs proliferation while cardiomyocyte-specific overexpression promotes it. RNA-seq and pharmacological studies identified glutamine synthetase as a key downstream effector of cpt1b in cardiomyocyte proliferation. cpt1b knockout zebrafish, cardiomyocyte-specific overexpression, RNA-seq, pharmacological inhibition Journal of cardiovascular development and disease Medium 39590187
2023 ABHD5 regulates placental lipid droplet storage through CPT1B; knockdown of ABHD5 increases lipid droplet accumulation in syncytiotrophoblast cells, and this effect is attenuated by downregulation of CPT1B, placing CPT1B downstream of ABHD5 in placental lipid metabolism. siRNA knockdown in BeWo cell syncytiotrophoblast model, lipid droplet staining, high-glucose stimulation, scRNA-seq validation Archives of medical research Low 38042031

Source papers

Stage 0 corpus · 47 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nature genetics 104 18820697
2019 Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 99 30846479
2021 The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway. Diabetes 97 34103347
2020 Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer. The Prostate 45 32648618
2018 Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B. Cardiovascular research 39 29635338
2002 Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals. The Journal of biological chemistry 38 12015320
2015 Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity. American journal of physiology. Endocrinology and metabolism 34 26058865
2020 Gan-Jiang-Ling-Zhu decoction alleviates hepatic steatosis in rats by the miR-138-5p/CPT1B axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 32 32325349
2014 Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle. Acta physiologica (Oxford, England) 30 25213552
2021 PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Cell reports 28 34610308
2010 Molecular characterization of a gilthead sea bream (Sparus aurata) muscle tissue cDNA for carnitine palmitoyltransferase 1B (CPT1B). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 28 20601065
1997 Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I. Biochimica et biophysica acta 28 9199240
2015 Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity. American journal of physiology. Regulatory, integrative and comparative physiology 26 25855307
2021 Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload. BMC biology 24 34330275
1998 Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene. Mammalian genome : official journal of the International Mammalian Genome Society 23 9680378
2019 Transcribed Ultraconserved Regions, Uc.323, Ameliorates Cardiac Hypertrophy by Regulating the Transcription of CPT1b (Carnitine Palmitoyl transferase 1b). Hypertension (Dallas, Tex. : 1979) 22 31735087
2013 Effects of cannabinoid receptor 1 (brain) on lipid accumulation by transcriptional control of CPT1A and CPT1B. Animal genetics 22 23914904
2021 miR-27a Regulates Sheep Adipocyte Differentiation by Targeting CPT1B Gene. Animals : an open access journal from MDPI 21 35011132
2009 Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men. Obesity (Silver Spring, Md.) 18 19553926
2021 Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences. Experimental physiology 17 33675111
2016 Cardiac-specific down-regulation of carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac remodeling in obese mice. Obesity (Silver Spring, Md.) 15 27804274
2018 High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. Diabetes & metabolism 14 29657112
2024 CPT1B maintains redox homeostasis and inhibits ferroptosis to induce gemcitabine resistance via the KEAP1/NRF2 axis in pancreatic cancer. Surgery 13 38302326
2013 Single nucleotide polymorphism in CPT1B and CPT2 genes and its association with blood carnitine levels in acute myocardial infarction patients. Gene 11 23566841
2020 Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue. Journal of molecular biology 10 33058877
2019 Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice. Cell and tissue research 10 31811407
2021 The effect of CPT1B gene on lipid metabolism and its polymorphism analysis in Chinese Simmental cattle. Animal biotechnology 8 33827354
2023 The influence of serum selenium in differential epigenetic and transcriptional regulation of CPT1B gene in women with obesity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 7 38183920
2014 Identification of the variations in the CPT1B and CHKB genes along with the HLA-DQB1*06:02 allele in Turkish narcolepsy patients and healthy persons. Genetic testing and molecular biomarkers 7 24571861
2023 CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML. Cancer biomarkers : section A of Disease markers 6 36938722
2025 AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model. Basic research in cardiology 5 40646338
2025 The TEX44-CPT1B axis regulates mitochondrial sheath assembly and fatty acid oxidation in sperm. Nature communications 5 40849303
2023 Transcription Factor MITF Inhibits the Transcription of CPT1B to Regulate Fatty Acid β-Oxidation and Thus Affects Stemness in Lung Adenocarcinoma Cells. Pharmacology 5 38016436
2024 2-Methoxyestradiol ameliorates doxorubicin-induced cardiotoxicity by regulating the expression of GLUT4 and CPT-1B in female rats. Naunyn-Schmiedeberg's archives of pharmacology 4 38652282
2024 The ZNF263/CPT1B axis regulates fatty acid β-oxidation to affect cisplatin resistance in lung adenocarcinoma. The pharmacogenomics journal 4 39500874
2024 Leptin increases chemosensitivity by inhibiting CPT1B in colorectal cancer cells. Journal of gastrointestinal oncology 4 39816028
2023 Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women. Frontiers in physiology 4 37275238
2023 ABHD5-CPT1B: An Important Way of Regulating Placental Lipid Metabolism in Gestational Diabetes Mellitus. Archives of medical research 4 38042031
2022 [Mstn knockdown promotes intramuscular fatty acid metabolism by β oxidation via the up-regulation of Cpt1b]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 4 36002433
2024 cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish. Journal of cardiovascular development and disease 2 39590187
2025 The role of quercetin in modulating lipid metabolism and enhancing chemotherapy via the STAT3-CPT1B pathway in pancreatic cancer. Biochemical and biophysical research communications 1 40412371
2025 Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4. Frontiers in molecular biosciences 1 40842820
2025 DHDK, a Plant-Derived Natural Small Molecule, Protects Against Doxorubicin-Induced Cardiotoxicity via the PPARG-CPT1B-FAO Axis. Pharmaceuticals (Basel, Switzerland) 1 41305001
2026 Kaempferol alleviates right ventricular hypertrophy in high-altitude pulmonary hypertension rats by modulating the AMPK/ACC/CPT1B axis and the AMPK-mediated LDHA/PDHA1 pathway. Food & function 0 41804727
2026 [Mechanism of Jianpi Huogu Formula in treatment of alcohol-induced osteonecrosis of femoral head via AdipoR/AMPKα/Cpt1b signaling axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 0 41814724
2026 Characterization of the cpt1b Gene in Response to a Tributyrin-Supplemented Diet: Cloning, Tissue-Specific Expression, and Intestinal Metabolic Function in Mandarin Fish (Siniperca chuatsi). Current issues in molecular biology 0 41899456
2025 CPT1B-Mediated Fatty Acid Oxidation Induces Pigmentation in Solar Lentigo. Pigment cell & melanoma research 0 41146460