Affinage

CPT1B

Carnitine O-palmitoyltransferase 1, muscle isoform · UniProt Q92523

Length
772 aa
Mass
87.8 kDa
Annotated
2026-06-09
50 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CPT1B is the muscle-type carnitine palmitoyltransferase I that catalyzes the rate-limiting, malonyl-CoA-inhibited step of mitochondrial long-chain fatty acid beta-oxidation (FAO) in heart and skeletal muscle (PMID:12015320, PMID:29635338). Its malonyl-CoA sensitivity sets cardiac FAO flux: a knock-in mouse with reduced sensitivity raises FAO ~1.9-fold and triggers compensatory downregulation of FAO genes (PMID:29635338). CPT1B activity is further tuned by post-translational modification at the protein level — oxygen-dependent PHD2/3-mediated proline-295 hydroxylation is required for its interaction with VDAC1 and for LCFA oxidation in cardiomyocytes (PMID:34610308), while P300-mediated lysine-321 crotonylation (opposed by CBP) impairs activity and promotes lipid deposition and mitochondrial dysfunction during endotoxic shock (PMID:42209697). CPT1B transcription is controlled by a broad set of regulators across tissues, including the MEF2A/HDAC5 axis driven by exercise (PMID:25213552), EZH2/H3K27me3-mediated repression (PMID:31735087), BHLHE40/HDAC1 repression (PMID:42128070), and additional factors such as SMAD3 (PMID:36002433), ZNF263, MITF, and androgen receptor in cancer contexts (PMID:32648618, PMID:39500874, PMID:38016436), with CpG methylation and PPARδ/HNF4α/USF occupancy shaping its lipid-responsive induction in skeletal muscle (PMID:26058865). Functionally, CPT1B-driven FAO is a regulated source of mitochondrial ROS: silencing it protects the obese heart from remodeling while aggravating lipid accumulation (PMID:27804274), and in sperm its binding partner TEX44 both anchors mitochondria into the sheath and restrains CPT1B activity to limit FAO-derived ROS, with germ-cell-specific Cpt1b loss causing sheath defects and reduced motility (PMID:40849303). Through a KEAP1 interaction that sustains NRF2 (PMID:38302326) and roles in cardiomyocyte hypertrophy and proliferation (PMID:40646338, PMID:39590187), CPT1B links lipid catabolism to redox homeostasis and cell fate.

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2002 High

    Established CPT1B as the muscle isoform catalyzing the rate-limiting step of long-chain FAO and showed that its splice variants are catalytically inactive, ruling out splicing as a mechanism for tuning malonyl-CoA inhibition.

    Evidence Heterologous expression of splice variants in Pichia pastoris with enzymatic activity assays and genomic/cDNA analysis

    PMID:12015320

    Open questions at the time
    • Did not define the physiological regulators of malonyl-CoA sensitivity
    • No structural model of the active enzyme
  2. 2014 Medium

    Showed that exercise drives CPT1B transcription through MEF2A recruitment and HDAC5 derepression, linking physical activity to muscle FAO capacity.

    Evidence ChIP, Cpt1b promoter luciferase reporters, MEF2A/HDAC5 overexpression in C2C12 cells, and fractionation in mouse muscle

    PMID:25213552

    Open questions at the time
    • Does not establish whether MEF2A/HDAC5 control CPT1B in non-muscle tissues
    • Upstream signals coupling exercise to HDAC5 phosphorylation only partially defined
  3. 2015 Medium

    Identified epigenetic control of CPT1B by CpG methylation and transcription factor occupancy, providing a mechanism for blunted FAO gene induction in obesity.

    Evidence Bisulfite sequencing, ChIP, and transcription factor binding assays in primary human skeletal muscle cultures

    PMID:26058865

    Open questions at the time
    • Causal link between specific methylated sites and clinical phenotype is correlative
    • Did not test methylation editing in vivo
  4. 2016 Medium

    Demonstrated that CPT1B-driven FAO is a source of cardiac ROS, since cardiac CPT1B silencing protected obese hearts from remodeling at the cost of lipid accumulation.

    Evidence Cardiac-specific lentiviral CPT1B knockdown in high-fat-diet mice with echocardiography, histology, and ROS measurement

    PMID:27804274

    Open questions at the time
    • Apparently opposite to later studies where CPT1B overexpression is cardioprotective — context dependence unresolved
    • Did not define how FAO flux generates ROS
  5. 2018 High

    Proved that malonyl-CoA inhibition of CPT1B sets the cardiac FAO rate in vivo and that loss of inhibition is buffered by transcriptional compensation.

    Evidence CPT1B E3A malonyl-CoA-insensitive knock-in mouse with perfused-heart FAO, metabolomics, proteomics, and transcriptomics

    PMID:29635338

    Open questions at the time
    • Mechanism of the compensatory FAO gene downregulation not identified
    • Long-term consequences for cardiac function not assessed
  6. 2021 High

    Revealed an oxygen-sensitive post-translational switch in which PHD2/3 hydroxylate CPT1B at Pro295 to enable VDAC1 binding and LCFA oxidation.

    Evidence Co-IP, P295A mutagenesis with functional rescue, and PHD2/3-knockout cardiomyocytes with FAO assays

    PMID:34610308

    Open questions at the time
    • How VDAC1 binding mechanistically supports FAO is unresolved
    • Stoichiometry and dynamics of hydroxylation under physiological oxygen tension not defined
  7. 2019 Medium

    Added EZH2/H3K27me3 repression of CPT1B as a node in cardiac hypertrophy, antagonized by lncRNA uc.323.

    Evidence ChIP, gain/loss-of-function in cardiomyocytes, CPT1B overexpression rescue, and aortic banding mice

    PMID:31735087

    Open questions at the time
    • How uc.323 directs EZH2 away from the CPT1B locus not detailed
    • Single lab
  8. 2022 Medium

    Placed CPT1B downstream of myostatin signaling, with SMAD3 directly binding its promoter to restrain muscle FAO.

    Evidence ChIP for SMAD3 promoter binding, Mstn-knockdown mice, and CPT1 activity/fatty acid composition assays

    PMID:36002433

    Open questions at the time
    • Whether SMAD3 acts as direct repressor or via cofactors unclear
    • Single lab
  9. 2024 Medium

    Connected CPT1B to redox control via a KEAP1 interaction sustaining NRF2 and protecting cancer cells from ferroptosis, and identified divergent cancer transcriptional regulators (ZNF263 activating, MITF repressing).

    Evidence Co-IP, siRNA knockdown with ferroptosis assays and xenografts; dual-luciferase and ChIP in lung adenocarcinoma cells

    PMID:38016436 PMID:38302326 PMID:39500874

    Open questions at the time
    • Whether KEAP1 binding depends on CPT1B catalytic activity unknown
    • Reciprocal validation of KEAP1 interaction limited
  10. 2025 High

    Defined a non-metabolic structural and rheostat role in sperm, where TEX44 anchors mitochondria into the sheath and restrains CPT1B activity to limit FAO-derived ROS.

    Evidence Co-IP, purified-protein in vitro activity assays, Tex44 and germ-cell-specific Cpt1b knockout mice, and patient whole-exome sequencing

    PMID:40849303

    Open questions at the time
    • How TEX44 binding biochemically inhibits CPT1B not resolved
    • Whether the mitochondrial-glue role requires CPT1B enzymatic function unclear
  11. 2026 High

    Identified lysine-321 crotonylation, written by P300 and protected by CBP, as a disease-associated PTM that impairs CPT1B and drives endotoxic cardiomyopathy.

    Evidence Crotonylproteomics, K321R mutagenesis with rescue, IP-based writer identification, and AAV9 cardiac overexpression in rats

    PMID:42209697

    Open questions at the time
    • Eraser enzyme for K321cr not identified
    • Crosstalk with Pro295 hydroxylation not examined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the many transcriptional, epigenetic, and post-translational inputs are integrated to set CPT1B activity in a given tissue, and whether its enzymatic versus scaffolding/redox roles are separable, remains unresolved.
  • No unified structural model linking Pro295 hydroxylation, K321 crotonylation, and VDAC1/TEX44/KEAP1 binding
  • Tissue-specific selection among the documented transcriptional regulators undefined
  • Reconciliation of protective vs. ROS-generating roles of CPT1B-driven FAO across heart contexts

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 4 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005739 mitochondrion 3
Pathway
R-HSA-74160 Gene expression (Transcription) 8 R-HSA-1430728 Metabolism 3 R-HSA-5357801 Programmed Cell Death 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
CBPKEAP1P300PHD2PHD3TEX44VDAC1

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 CPT1B (M-CPT I) encodes the muscle-type carnitine palmitoyltransferase I isoform responsible for the rate-limiting step in beta-oxidation of long-chain fatty acids in heart and skeletal muscle. When three previously described splice variants were expressed in Pichia pastoris, none had CPT I enzymatic activity, indicating that splice variation of M-CPT I does not modulate malonyl-CoA inhibition of fatty acid oxidation as previously proposed. Heterologous expression in Pichia pastoris, enzymatic activity assay, genomic/cDNA structural analysis The Journal of biological chemistry High 12015320
2018 Malonyl-CoA-dependent inhibition of CPT1B plays a crucial role in regulating cardiac fatty acid oxidation rate. A knock-in mouse expressing CPT1B E3A mutant (reduced malonyl-CoA sensitivity) showed 1.9-fold higher FAO in isolated perfused hearts, along with increased malonylcarnitine, decreased CPT1B protein, and coordinated downregulation of FAO gene mRNA expression as compensatory responses. Knock-in mouse model, isolated perfused heart FAO measurements, metabolomics, proteomics, transcriptomics Cardiovascular research High 29635338
2021 PHD2/3 (prolyl hydroxylase domain proteins) bind to CPT1B and promote hydroxylation of CPT1B at proline 295 (P295). This P295 hydroxylation is required for CPT1B interaction with VDAC1 and for long-chain fatty acid beta-oxidation in cardiomyocytes. A CPT1B-P295A mutant constitutively binds VDAC1 and rescues LCFA metabolism in PHD2/3-deficient cardiomyocytes, establishing an oxygen-sensitive regulatory axis for cardiac metabolism. Co-immunoprecipitation, mutagenesis (P295A knock-in), cardiomyocyte loss-of-function (PHD2/3 knockout mice), rescue experiments, FAO assays Cell reports High 34610308
2025 TEX44 interacts physically with CPT1B to form a mitochondrial glue that anchors adjacent mitochondria and facilitates assembly of the sperm-specific mitochondrial sheath. Purified TEX44 protein modulates CPT1B enzymatic activity in vitro, limiting conversion of long-chain fatty acids (palmitic acid, myristic acid) to acyl-carnitines and thereby reducing ROS production. Loss of TEX44 leads to unregulated FAO, excessive ROS, and oxidative damage to sperm DNA and flagellar structure. Germ cell-specific Cpt1b knockout mice recapitulate TEX44-deficiency phenotypes including mitochondrial sheath defects and reduced sperm motility. Co-immunoprecipitation, purified protein in vitro enzymatic activity assay, Tex44 knockout mice, germ cell-specific Cpt1b knockout mice, whole-exome sequencing of patients Nature communications High 40849303
2026 CPT1B is crotonylated at lysine 321 (K321cr) during endotoxic shock, and this modification impairs CPT1B enzymatic activity. The crotonyl-transferase P300 promotes K321 crotonylation while CBP normally protects CPT1B from this modification; LPS induces dissociation of CBP from CPT1B and recruitment of P300. K321R mutation prevents crotonylation, alleviates lipid droplet deposition and mitochondrial dysfunction (restored ATP and mitochondrial membrane potential), and protects against endotoxic shock-induced cardiomyopathy in vivo. Crotonylproteomic mass spectrometry, site-directed mutagenesis (K321R), LC-MS/MS identification of writer enzymes (P300/CBP), AAV9 cardiac-specific overexpression in rats, co-immunoprecipitation, enzymatic activity assays Experimental & molecular medicine High 42209697
2014 Exercise training increases binding of MEF2A transcription factor to the Cpt1b promoter in mouse skeletal muscle, while decreasing binding of the repressor HDAC5. MEF2A overexpression in C2C12 myoblasts increases Cpt1b mRNA and promoter transcriptional activity, effects suppressed by HDAC5. Exercise induces MEF2A hyperacetylation, increases HDAC5 phosphorylation at Ser259/Ser498, and causes nuclear export of HDAC5, collectively driving CPT1B transcription. Chromatin immunoprecipitation (ChIP), reporter gene assay (Cpt1b promoter luciferase), MEF2A and HDAC5 overexpression in C2C12 cells, real-time PCR, Western blot, nuclear/cytoplasmic fractionation Acta physiologica (Oxford, England) Medium 25213552
2019 EZH2 binds to the CPT1b promoter via H3K27me3 to repress CPT1b transcription during cardiac hypertrophy. The long noncoding RNA uc.323 protects against hypertrophy partly by interacting with EZH2, preventing CPT1b repression; overexpression of CPT1b blocks uc.323-mediated cardiomyocyte hypertrophy. Chromatin immunoprecipitation (ChIP), microarray mRNA expression analysis, gain/loss-of-function in cardiomyocytes, CPT1b overexpression rescue experiments, aortic banding mouse model Hypertension (Dallas, Tex. : 1979) Medium 31735087
2015 In response to lipid exposure, CPT1B gene transcription in skeletal muscle is regulated by epigenetic modifications including CpG methylation, H3/H4 histone acetylation, and transcription factor occupancy (PPARδ and HNF4α) at the CPT1B promoter. Methylation of specific CpG sites blocks binding of the transcription factor USF (upstream stimulatory factor), suggesting a causal mechanism for the blunted CPT1B induction seen in severely obese individuals. Primary human skeletal muscle cultures, bisulfite sequencing (CpG methylation), ChIP (histone acetylation, transcription factor occupancy), RT-PCR, transcription factor binding assays American journal of physiology. Endocrinology and metabolism Medium 26058865
2020 Androgen receptor (AR) regulates CPT1B transcriptional activity via specific binding sites in the CPT1B promoter, as confirmed by dual luciferase reporter assay and ChIP assay in prostate cancer cells. AR inhibition affects CPT1B expression; CPT1B overexpression in enzalutamide-resistant C4-2R cells increases AKT expression and phosphorylation, promoting drug resistance. Dual luciferase reporter assay, chromatin immunoprecipitation (ChIP), JASPAR binding site analysis, stable knockdown/overexpression cell lines, CCK-8 assay The Prostate Medium 32648618
2024 ZNF263 transcription factor binds to the CPT1B promoter to activate its transcription, thereby enhancing fatty acid beta-oxidation and promoting cisplatin resistance in lung adenocarcinoma cells. This was confirmed by dual-luciferase reporter assay and ChIP assay. Dual-luciferase reporter assay, chromatin immunoprecipitation (ChIP), qRT-PCR, Western blot, FAO rate measurement, IC50 assay (CCK-8) The pharmacogenomics journal Medium 39500874
2023 MITF transcription factor binds the CPT1B promoter and inhibits its transcription in lung adenocarcinoma cells, reducing fatty acid beta-oxidation and suppressing cancer stem cell stemness. Confirmed by dual-luciferase reporter assay and ChIP assay. Dual-luciferase reporter assay, ChIP assay, qRT-PCR, Western blot, sphere-forming assay, FAO measurement Pharmacology Medium 38016436
2025 STAT3 directly interacts with CPT1B in pancreatic cancer stem cells, as demonstrated by chromatin immunoprecipitation assay. Manipulation of STAT3 expression (overexpression or siRNA knockdown) alters CPT1B mRNA and protein levels. Quercetin inhibits CPT1B expression via the STAT3 signaling pathway, affecting lipid metabolism. Chromatin immunoprecipitation (ChIP), STAT3 siRNA knockdown and overexpression, qRT-PCR, Western blot, CCK-8, sphere formation assay Biochemical and biophysical research communications Low 40412371
2019 In LRP6 cardiac-specific knockout mice, CPT1B protein is sharply decreased coincident with Drp1 activation, and Drp1 inhibitor restores CPT1B expression. In cardiomyocytes in vitro, c-Myc (but not CTCF) was identified as a transcriptional regulator of CPT1B expression and lipid accumulation. Cardiac-specific LRP6 knockout mice, Drp1 inhibitor treatment, GC-FID/MS fatty acid analysis, ChIP-like transcription factor binding assay, c-Myc overexpression in cardiomyocytes Cell and tissue research Low 31811407
2013 CB1 (cannabinoid receptor 1) is upstream of CPT1B in porcine intramuscular adipocytes: CB1 agonist (Δ9-THC) decreased CPT1B mRNA and increased lipid accumulation, while CB1 antagonist (SR141716) increased CPT1B mRNA and decreased lipid accumulation. CPT1 antagonist etomoxir did not affect CB1 expression, confirming CB1 is upstream of CPT1B. PPARα expression was co-regulated with CPT1B. Pharmacological agonist/antagonist treatment of porcine intramuscular adipocytes, mRNA expression analysis, lipid accumulation assay Animal genetics Low 23914904
2022 SMAD3, a transcription factor downstream of myostatin (Mstn) signaling, directly binds to the Cpt1b promoter as shown by chromatin immunoprecipitation. Mstn knockdown upregulates Cpt1b expression and CPT1 enzyme activity in skeletal muscle, promoting fatty acid beta-oxidation. Chromatin immunoprecipitation (ChIP) for SMAD3 binding to Cpt1b promoter, RNA interference (Mstn knockdown mice), CPT1 enzyme activity assay, fatty acid composition analysis Sheng wu gong cheng xue bao = Chinese journal of biotechnology Medium 36002433
2021 In proximal tubular epithelial cells, ANXA1 silencing suppresses phosphorylation of AMPK at Thr172 via FPR2/ALX signaling, leading to decreased PPARα and CPT1B expression and increased lipid accumulation. This places CPT1B downstream of the ANXA1/FPR2/AMPK/PPARα axis in renal lipid metabolism. siRNA knockdown of ANXA1 in human PTECs, phospho-AMPK Western blot, CPT1B expression measurement, lipid accumulation assay, diabetic mouse model with ANXA1 deletion Diabetes Low 34103347
2024 CPT1B interacts with KEAP1 (Kelch-like ECH-associated protein 1), and CPT1B knockdown leads to decreased NRF2 expression and induction of ferroptosis in pancreatic cancer cells, establishing a CPT1B-KEAP1-NRF2 regulatory connection that maintains redox homeostasis. Co-immunoprecipitation (CPT1B-KEAP1 interaction), CPT1B siRNA knockdown, NRF2 expression measurement, ROS/lipid peroxidation/glutathione assays, flow cytometry for ferroptosis markers, xenograft model Surgery Medium 38302326
2026 BHLHE40 recruits HDAC1 to the CPT1B promoter (confirmed by CUT&Tag) to transcriptionally repress CPT1B expression, impairing NRF2 signaling and driving ferroptosis in E. coli-infected endometrial cells. Overexpression of CPT1B reactivates NRF2 and its downstream targets to inhibit ferroptosis. CUT&Tag, RNA-sequencing, CPT1B overexpression rescue, NRF2 inhibitor epistasis, siRNA knockdown of BHLHE40, lipid peroxidation/glutathione/Fe2+ assays Free radical biology & medicine Medium 42128070
2025 AAV-mediated cardiac overexpression of CPT1B in neonatal rat cardiomyocytes attenuates phenylephrine-induced hypertrophy and decreases mitochondrial ROS generation. In mice subjected to transverse aortic constriction (TAC), cardiac CPT1B overexpression attenuates cardiomyocyte hypertrophy, cardiac fibrosis, and systolic dysfunction in vivo. AAV gene transfer to neonatal rat cardiomyocytes and mouse hearts, phenylephrine-induced hypertrophy model, TAC pressure overload model, mitochondrial ROS measurement, echocardiography, histology Basic research in cardiology Medium 40646338
2024 cpt1b regulates cardiomyocyte proliferation during zebrafish development through modulation of glutamine synthetase. Knockout of cpt1b impairs cardiomyocyte proliferation, while cardiomyocyte-specific overexpression promotes it. Pharmacological studies and RNA sequencing identified glutamine synthetase as a key downstream effector. cpt1b knockout zebrafish, cardiomyocyte-specific cpt1b overexpression, RNA sequencing, pharmacological glutamine synthetase inhibition Journal of cardiovascular development and disease Medium 39590187
2020 miR-138-5p directly targets CPT1B mRNA: miR-138-5p mimic reduces CPT1B expression and luciferase activity from a wild-type CPT1B 3'UTR reporter, while miR-138-5p inhibitor increases CPT1B expression. When CPT1B is mutated at the predicted binding site, miR-138-5p can no longer regulate luciferase activity, confirming direct targeting. Dual-luciferase reporter assay with wild-type and mutant CPT1B 3'UTR, miR-138-5p mimic/inhibitor transfection, RT-PCR Biomedicine & pharmacotherapy Medium 32325349
2016 Cardiac-specific CPT1B silencing (via intramyocardial lentiviral injection) in obese mice on a high-fat diet protected against HFD-induced cardiac remodeling by decreasing heart weight/tibial length ratio, improving left ventricular ejection fraction and fractional shortening, reducing intramyocardial ROS production, and aggravating myocardial lipid accumulation, indicating CPT1B-driven FAO is a source of ROS in the obese heart. Lentiviral cardiac-specific CPT1B knockdown in mice, HFD obesity model, echocardiography, histology, biochemical parameters, ROS measurement Obesity (Silver Spring, Md.) Medium 27804274
2025 PPARG activation by the compound DHDK upregulates CPT1B expression, enhancing fatty acid beta-oxidation (FAO) in cardiomyocytes. This protective effect is abolished by inhibition of either PPARG or CPT1B, placing CPT1B downstream of PPARG in the cardioprotective PPARG-CPT1B-FAO axis. Molecular docking, lipidomics, qPCR, Western blot, CCK-8, flow cytometry, pharmacological inhibition of PPARG and CPT1B, in vivo rat model Pharmaceuticals (Basel, Switzerland) Low 41305001

Source papers

Stage 0 corpus · 50 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nature genetics 105 18820697
2021 The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway. Diabetes 102 34103347
2019 Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 100 30846479
2020 Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer. The Prostate 45 32648618
2018 Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B. Cardiovascular research 40 29635338
2002 Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals. The Journal of biological chemistry 38 12015320
2015 Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity. American journal of physiology. Endocrinology and metabolism 34 26058865
2020 Gan-Jiang-Ling-Zhu decoction alleviates hepatic steatosis in rats by the miR-138-5p/CPT1B axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 32 32325349
2021 PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Cell reports 30 34610308
2014 Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle. Acta physiologica (Oxford, England) 30 25213552
2010 Molecular characterization of a gilthead sea bream (Sparus aurata) muscle tissue cDNA for carnitine palmitoyltransferase 1B (CPT1B). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 29 20601065
1997 Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I. Biochimica et biophysica acta 28 9199240
2021 Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload. BMC biology 26 34330275
2015 Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity. American journal of physiology. Regulatory, integrative and comparative physiology 26 25855307
2019 Transcribed Ultraconserved Regions, Uc.323, Ameliorates Cardiac Hypertrophy by Regulating the Transcription of CPT1b (Carnitine Palmitoyl transferase 1b). Hypertension (Dallas, Tex. : 1979) 23 31735087
2013 Effects of cannabinoid receptor 1 (brain) on lipid accumulation by transcriptional control of CPT1A and CPT1B. Animal genetics 23 23914904
1998 Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene. Mammalian genome : official journal of the International Mammalian Genome Society 23 9680378
2021 miR-27a Regulates Sheep Adipocyte Differentiation by Targeting CPT1B Gene. Animals : an open access journal from MDPI 22 35011132
2009 Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men. Obesity (Silver Spring, Md.) 18 19553926
2021 Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences. Experimental physiology 17 33675111
2024 CPT1B maintains redox homeostasis and inhibits ferroptosis to induce gemcitabine resistance via the KEAP1/NRF2 axis in pancreatic cancer. Surgery 16 38302326
2016 Cardiac-specific down-regulation of carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac remodeling in obese mice. Obesity (Silver Spring, Md.) 15 27804274
2018 High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. Diabetes & metabolism 14 29657112
2013 Single nucleotide polymorphism in CPT1B and CPT2 genes and its association with blood carnitine levels in acute myocardial infarction patients. Gene 11 23566841
2020 Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue. Journal of molecular biology 10 33058877
2019 Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice. Cell and tissue research 10 31811407
2021 The effect of CPT1B gene on lipid metabolism and its polymorphism analysis in Chinese Simmental cattle. Animal biotechnology 9 33827354
2025 AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model. Basic research in cardiology 7 40646338
2023 CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML. Cancer biomarkers : section A of Disease markers 7 36938722
2023 The influence of serum selenium in differential epigenetic and transcriptional regulation of CPT1B gene in women with obesity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 7 38183920
2014 Identification of the variations in the CPT1B and CHKB genes along with the HLA-DQB1*06:02 allele in Turkish narcolepsy patients and healthy persons. Genetic testing and molecular biomarkers 7 24571861
2025 The TEX44-CPT1B axis regulates mitochondrial sheath assembly and fatty acid oxidation in sperm. Nature communications 6 40849303
2024 The ZNF263/CPT1B axis regulates fatty acid β-oxidation to affect cisplatin resistance in lung adenocarcinoma. The pharmacogenomics journal 6 39500874
2023 Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women. Frontiers in physiology 5 37275238
2023 Transcription Factor MITF Inhibits the Transcription of CPT1B to Regulate Fatty Acid β-Oxidation and Thus Affects Stemness in Lung Adenocarcinoma Cells. Pharmacology 5 38016436
2024 2-Methoxyestradiol ameliorates doxorubicin-induced cardiotoxicity by regulating the expression of GLUT4 and CPT-1B in female rats. Naunyn-Schmiedeberg's archives of pharmacology 4 38652282
2024 Leptin increases chemosensitivity by inhibiting CPT1B in colorectal cancer cells. Journal of gastrointestinal oncology 4 39816028
2023 ABHD5-CPT1B: An Important Way of Regulating Placental Lipid Metabolism in Gestational Diabetes Mellitus. Archives of medical research 4 38042031
2022 [Mstn knockdown promotes intramuscular fatty acid metabolism by β oxidation via the up-regulation of Cpt1b]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 4 36002433
2024 cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish. Journal of cardiovascular development and disease 3 39590187
2025 The role of quercetin in modulating lipid metabolism and enhancing chemotherapy via the STAT3-CPT1B pathway in pancreatic cancer. Biochemical and biophysical research communications 1 40412371
2025 Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4. Frontiers in molecular biosciences 1 40842820
2025 CPT1B-Mediated Fatty Acid Oxidation Induces Pigmentation in Solar Lentigo. Pigment cell & melanoma research 1 41146460
2025 DHDK, a Plant-Derived Natural Small Molecule, Protects Against Doxorubicin-Induced Cardiotoxicity via the PPARG-CPT1B-FAO Axis. Pharmaceuticals (Basel, Switzerland) 1 41305001
2026 Kaempferol alleviates right ventricular hypertrophy in high-altitude pulmonary hypertension rats by modulating the AMPK/ACC/CPT1B axis and the AMPK-mediated LDHA/PDHA1 pathway. Food & function 0 41804727
2026 [Mechanism of Jianpi Huogu Formula in treatment of alcohol-induced osteonecrosis of femoral head via AdipoR/AMPKα/Cpt1b signaling axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 0 41814724
2026 Characterization of the cpt1b Gene in Response to a Tributyrin-Supplemented Diet: Cloning, Tissue-Specific Expression, and Intestinal Metabolic Function in Mandarin Fish (Siniperca chuatsi). Current issues in molecular biology 0 41899456
2026 CPT1B promotes acute myeloid leukemia progression via fatty acid oxidation-dependent metabolic reprogramming. Translational oncology 0 42102499
2026 BHLHE40 drives ferroptosis in Escherichia coli-induced endometrial injury by recruiting HDAC1 to repress CPT1B and impair NRF2 signaling. Free radical biology & medicine 0 42128070
2026 CPT1B K321 crotonylation contributes to cardiac dysfunction in endotoxic shock. Experimental & molecular medicine 0 42209697

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