Affinage

PSMA7

Proteasome subunit alpha type-7 · UniProt O14818

Length
248 aa
Mass
27.9 kDa
Annotated
2026-06-10
89 papers in source corpus 14 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PSMA7 is an alpha-type subunit of the 20S proteasome that couples core proteolytic capacity to specific regulatory circuits in trafficking, signaling, and stress responses rather than acting solely as a passive structural component (PMID:16678104, PMID:25620702). Its activity is gated by tyrosine phosphorylation: c-Abl and Arg kinases associate with PSMA7 and phosphorylate it at Tyr-153, which compromises proteasome-dependent proteolysis and is required for normal G1/S and S/G2 cell cycle progression (PMID:16678104); phosphorylation at Tyr-106 blocks BRCA1-mediated ubiquitination and degradation of PSMA7 itself, stabilizing the subunit and allowing c-Abl to raise cellular proteasome abundance to compensate for oxidative-stress-induced loss of proteasome activity (PMID:25620702). Through its association with the 20S proteasome, PSMA7 promotes proteasome-dependent turnover of multiple regulatory substrates: it associates with MAVS and suppresses RIG-I/MAVS-driven type I interferon production, acting as a negative regulator of antiviral innate immunity (PMID:19734229); it binds HIF-1alpha and inhibits its transactivation function, an effect amplified when internalized EMAP-II engages cytoplasmic PSMA7 to drive HIF-1alpha degradation and limit angiogenic sprouting (PMID:11389899, PMID:19362550); and it associates with NOD1 to downregulate NOD1-mediated NF-kB activation and apoptosis (PMID:23839082). Independently of bulk degradation, GTP-bound Rab7 recruits PSMA7 to multivesicular late endosomes, where PSMA7 negatively regulates late endocytic transport of membrane proteins such as EGFR, linking proteasomal machinery to the endocytic pathway (PMID:14998988, PMID:16473627). PSMA7 is also required specifically for HCV IRES-mediated translation (PMID:11713272). In cancer models, PSMA7 supports proliferation, invasion, and tumorigenicity, and its abundance is set by opposing deubiquitinase and E3 ligase activities, including a UCHL1-PSMA7-APEH proteasome axis and a USP10/RNF20 axis controlling PSMA7 stability (PMID:19787246, PMID:33753553, PMID:41254650).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2001 Medium

    Established that PSMA7 is not merely a degradation subunit but can act as a negative regulator of a specific transcription factor, linking the proteasome to hypoxic signaling.

    Evidence Co-IP/interaction mapping and transactivation reporter assays for HIF-1alpha

    PMID:11389899

    Open questions at the time
    • Did not define whether inhibition is via direct HIF-1alpha degradation or sequestration
    • Single lab, no in vivo validation
  2. 2001 Medium

    Showed PSMA7 has a translation-related role, being specifically required for HCV IRES-dependent but not cap-dependent translation.

    Evidence Ribozyme knockdown plus MG132 inhibition in bicistronic reporter cell lines

    PMID:11713272

    Open questions at the time
    • Molecular mechanism by which PSMA7 supports IRES activity not resolved
    • No direct PSMA7-IRES or PSMA7-ribosome interaction shown
  3. 2004 High

    Resolved a non-proteolytic role by showing GTP-Rab7 recruits PSMA7 to late endosomes to negatively regulate endocytic transport, connecting proteasome subunits to membrane trafficking.

    Evidence Reciprocal Co-IP, GST pulldown with domain mapping, microscopy/fractionation, and endocytic transport assays with Rab7 rescue

    PMID:14998988

    Open questions at the time
    • Whether the 20S proteasome itself is required at endosomes vs free PSMA7 unclear
    • Endogenous-level (non-overexpression) confirmation limited
  4. 2005 Medium

    Confirmed and extended the Rab7 interaction, positioning PSMA7 as a molecular link between endocytic and cytosolic degradative machineries.

    Evidence Co-IP, GST pulldown, 20S proteasome association and endosome fractionation

    PMID:16473627

    Open questions at the time
    • Largely confirmatory of the 2004 study
    • Functional consequence of proteasome-endosome coupling not independently tested
  5. 2006 High

    Identified a kinase-controlled switch: c-Abl/Arg phosphorylation of PSMA7 at Tyr-153 modulates proteasome proteolysis and cell cycle progression, establishing post-translational regulation of proteasome function through this subunit.

    Evidence Co-IP, in vitro kinase assay, Y153F mutagenesis, cell cycle analysis

    PMID:16678104

    Open questions at the time
    • Mechanism by which Tyr-153 phosphorylation alters 20S catalytic activity not structurally defined
    • Direct substrates whose turnover is altered not enumerated
  6. 2009 High

    Defined PSMA7 as a negative regulator of antiviral innate immunity by promoting MAVS turnover and dampening type I IFN responses.

    Evidence Reciprocal Co-IP, siRNA knockdown, IFN-beta reporter, viral replication and MAVS abundance immunoblotting

    PMID:19734229

    Open questions at the time
    • Whether PSMA7 acts through full 20S/26S degradation or a direct effect on MAVS unresolved
    • Upstream signal triggering virus-induced PSMA7 increase unknown
  7. 2009 Medium

    Connected extracellular EMAP-II/integrin signaling to PSMA7-driven HIF-1alpha degradation, providing a physiological route to suppress angiogenesis.

    Evidence Co-IP, internalization assays, HIF-1alpha degradation and angiogenic sprouting assays

    PMID:19362550

    Open questions at the time
    • How internalized EMAP-II reaches cytoplasmic PSMA7 not mechanistically defined
    • Single lab
  8. 2009 Medium

    Demonstrated a pro-tumorigenic role for PSMA7 in colorectal cancer, linking its loss to suppressed growth, invasion, and CD44 expression.

    Evidence shRNA knockdown with anchorage-independent growth, invasion/migration, xenograft, and CD44 immunoblotting

    PMID:19787246

    Open questions at the time
    • Mechanistic link from PSMA7 to CD44 not established
    • Whether effect reflects general proteasome dependence vs PSMA7-specific function unclear
  9. 2013 High

    Identified NOD1 as a PSMA7 partner and showed proteasome-dependent downregulation of NOD1 suppresses NF-kB and apoptosis, extending PSMA7's immune-regulatory range.

    Evidence Y2H, Co-IP, GST pulldown, ubiquitin assay, NF-kB reporter and apoptosis assays

    PMID:23839082

    Open questions at the time
    • E3 ligase directing NOD1 ubiquitination not identified
    • In vivo relevance to bacterial sensing not tested
  10. 2015 High

    Established a feedback loop controlling proteasome abundance: BRCA1 ubiquitinates PSMA7 for degradation, while c-Abl/Arg phosphorylation at Tyr-106 stabilizes it, enabling proteasome upregulation under oxidative stress.

    Evidence In vitro ubiquitination with BRCA1, Y106 mutagenesis, RNAi/KO models, proteasome activity and oxidative stress assays

    PMID:25620702

    Open questions at the time
    • How PSMA7 subunit supply quantitatively sets assembled proteasome levels not fully defined
    • Crosstalk between Tyr-153 and Tyr-106 phosphorylation unresolved
  11. 2018 Medium

    Showed PSMA7 loss reduces 20S proteasome activity and shifts cell-cycle/apoptosis balance in cervical cancer, reinforcing its role in proteasome-dependent proliferation control.

    Evidence shRNA knockdown, proteasome activity, RT-qPCR/Western, proliferation, cell-cycle and apoptosis flow cytometry

    PMID:29247526

    Open questions at the time
    • Changes in p53/p27/VEGF may be downstream of general proteasome loss
    • No direct substrate causality demonstrated
  12. 2021 Medium

    Placed PSMA7 within a UCHL1-PSMA7-APEH axis sustaining protein homeostasis and proteasome activity in ovarian carcinoma.

    Evidence UCHL1 knockdown, proteasome activity, polyubiquitin/PSMA7/APEH immunoblotting, xenograft, transcriptional profiling

    PMID:33753553

    Open questions at the time
    • Whether UCHL1 directly deubiquitinates PSMA7 not shown
    • Mechanism coupling APEH to proteasome activity unclear
  13. 2025 Medium

    Identified opposing deubiquitinase/E3 ligase control of PSMA7 stability (USP10 stabilizing, RNF20 degrading) downstream of melittin in NSCLC metastasis and EMT.

    Evidence Co-IP for USP10 and RNF20, CHX chase, MG132, PSMA7 overexpression rescue, migration and in vivo metastasis assays

    PMID:41254650

    Open questions at the time
    • Direct ubiquitination of PSMA7 by RNF20 not reconstituted
    • How PSMA7 promotes EMT mechanistically not defined
  14. 2025 Low

    Implicated PSMA7 as part of a proteasome subnetwork required for heart development.

    Evidence PPI network analysis and CRISPR screening in zebrafish embryos (preprint)

    Open questions at the time
    • Preprint; PSMA7-specific mechanistic follow-up focused on other subunits
    • No tissue-specific mechanism for PSMA7 in cardiogenesis established

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether PSMA7's many substrate-specific regulatory effects (MAVS, HIF-1alpha, NOD1) occur through assembled 20S/26S proteasome activity or through distinct functions of the free subunit, and how tyrosine phosphorylation structurally reprograms proteasome activity.
  • No structural model of phospho-PSMA7 in the proteasome
  • Substrate-selectivity mechanism unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0005198 structural molecule activity 2 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005768 endosome 2 GO:0005829 cytosol 2 GO:0005634 nucleus 1
Pathway
R-HSA-1640170 Cell Cycle 2 R-HSA-168256 Immune System 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-5653656 Vesicle-mediated transport 2
Partners
ABL1BRCA1HIF1AMAVSNOD1RAB7ARNF20USP10
Complex memberships
20S proteasome

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 PSMA7 (XAPC7) interacts specifically with the GTP-bound form of Rab7 via its C-terminus (interacting with the N-terminus of Rab7), and is recruited to multivesicular late endosomes through this interaction. XAPC7 was not found on early or recycling endosomes. Overexpression of XAPC7 impaired late endocytic transport of membrane proteins including EGFR, and this impairment was partially rescued by co-expression of wild-type Rab7, establishing a negative regulatory role for XAPC7 in late endocytic transport. Co-immunoprecipitation, GST pulldown, domain-mapping mutagenesis, fluorescence microscopy/subcellular fractionation, functional endocytic transport assays with overexpression The Journal of biological chemistry High 14998988
2001 PSMA7 interacts with two subdomains of HIF-1alpha and inhibits HIF-1alpha transactivation function under both normoxic and hypoxia-mimicking conditions; this regulatory effect is associated with the proteasome pathway. Co-immunoprecipitation, yeast two-hybrid or pulldown (interaction mapping), transactivation reporter assays FEBS letters Medium 11389899
2001 PSMA7 is required for HCV IRES-mediated translation. Ribozyme-mediated knockdown of PSMA7 mRNA inhibited HCV IRES activity in reporter cell systems, and the proteasome inhibitor MG132 exerted a dose-dependent inhibitory effect on HCV IRES-mediated translation but not on cap-dependent translation. This establishes a specific role for PSMA7 in HCV IRES-dependent translation. Ribozyme-based knockdown of PSMA7 in HeLa and Huh7 reporter cell lines, pharmacological proteasome inhibition (MG132), bicistronic reporter assays Molecular and cellular biology Medium 11713272
2006 c-Abl and Arg tyrosine kinases associate with and phosphorylate PSMA7 at Tyr-153. This phosphorylation compromises proteasome-dependent proteolysis. Cells expressing the phosphorylation-deficient mutant PSMA7(Y153F) display impaired G1/S and S/G2 cell cycle progression. Co-immunoprecipitation, in vitro kinase assay, site-directed mutagenesis (Y153F), cell cycle analysis Molecular cell High 16678104
2009 PSMA7 associates with MAVS (mitochondrial antiviral signaling protein) both in vivo and in vitro. Overexpression of PSMA7 potently inhibits RIG-I- and MAVS-mediated IFN-beta promoter activity and reduces endogenous MAVS abundance. Conversely, siRNA-mediated depletion of PSMA7 enhances virus-induced type I IFN production and reduces virus replication. Virus infection transiently increases endogenous PSMA7 protein levels, suggesting PSMA7 functions as a negative regulator of MAVS-mediated innate immunity. Co-immunoprecipitation (in vivo and in vitro), siRNA knockdown, IFN-beta promoter reporter assay, viral replication assay, immunoblotting for MAVS abundance Journal of immunology (Baltimore, Md. : 1950) High 19734229
2009 EMAP-II binds to cell surface alpha5beta1 integrin on endothelial cells, is internalized, and then interacts with cytoplasmic PSMA7 (a proteasome component). This interaction increases HIF-1alpha degradation under hypoxic conditions, resulting in inhibition of HIF-1alpha-mediated transcriptional activity and angiogenic sprouting. Co-immunoprecipitation, binding/internalization assays, HIF-1alpha stability/degradation assays, angiogenic sprouting assay Experimental cell research Medium 19362550
2013 PSMA7 associates with NOD1 (nucleotide-binding oligomerization domain-containing protein 1) as determined by yeast two-hybrid screening, co-immunoprecipitation, and GST pulldown. PSMA7 downregulates NOD1 expression in a proteasome-dependent manner. Overexpression of PSMA7 inhibits NOD1-mediated apoptosis and NF-κB activation, while knockdown of PSMA7 enhances NOD1 activity. Yeast two-hybrid, co-immunoprecipitation, GST pulldown, Western blotting, ubiquitin assay, NF-κB reporter assay, apoptosis assay Cellular physiology and biochemistry High 23839082
2015 PSMA7 is subject to ubiquitination and proteasomal degradation. BRCA1 functions specifically as the E3 ubiquitin ligase for PSMA7 ubiquitination. Phosphorylation of PSMA7 at Y106 by c-Abl/Arg suppresses this ubiquitination and degradation, thereby stabilizing PSMA7. c-Abl/Arg regulates cellular proteasome abundance by controlling PSMA7 subunit supply. In response to oxidative stress, c-Abl-mediated upregulation of proteasome levels compensates for ROS-induced proteasomal activity impairment. Ubiquitination assay, co-immunoprecipitation, siRNA/shRNA knockdown, site-directed mutagenesis (Y106), proteasome activity measurement, oxidative stress treatment Cell reports High 25620702
2005 XAPC7 (PSMA7) directly interacts with Rab7 GTPase; the interaction was validated and domain requirements confirmed. XAPC7 associates with the 20S proteasome and participates in endocytic trafficking machinery through this Rab7 interaction, providing a molecular link between the endocytic and cytosolic degradative machineries. Co-immunoprecipitation, GST pulldown, 20S proteasome association assays, endosome fractionation Methods in enzymology Medium 16473627
2009 shRNA-mediated depletion of PSMA7 in colorectal cancer RKO cells inhibited anchorage-independent growth, cell invasion, and migration, and strongly suppressed in vivo tumorigenicity. These effects were associated with inhibition of CD44 expression, suggesting PSMA7 promotes cancer progression at least partly through regulation of CD44. shRNA knockdown, anchorage-independent growth assay, Transwell invasion/migration assay, xenograft tumor model, immunoblotting for CD44 Oncology reports Medium 19787246
2021 UCHL1 (deubiquitinase) maintains protein homeostasis in high-grade serous ovarian carcinoma through a PSMA7-APEH-proteasome axis. Silencing UCHL1 reduces PSMA7 and APEH expression, resulting in decreased proteasome activity, impaired protein degradation, accumulation of polyubiquitinated proteins, and abrogated cancer cell growth. siRNA/shRNA knockdown of UCHL1, proteasome activity assay, immunoblotting for PSMA7/APEH/polyubiquitinated proteins, xenograft in vivo growth assay, transcriptional profiling Molecular cancer research : MCR Medium 33753553
2018 shRNA-mediated silencing of PSMA7 in cervical cancer SiHa cells decreased 20S proteasome activity, reduced PSMA7, ubiquitin, p53, and VEGF expression, increased p27 expression, inhibited cell proliferation and S-phase entry, promoted G0/G1 arrest, and increased apoptosis, demonstrating that PSMA7 regulates the ubiquitin-proteasome pathway to control cell cycle and VEGF expression. shRNA knockdown, immunofluorescence for 20S proteasome activity, RT-qPCR, Western blot, MTT proliferation assay, flow cytometry for cell cycle and apoptosis Journal of cellular physiology Medium 29247526
2011 XAPC7 (PSMA7) protein is predominantly cytoplasmic in 786-O and Chang liver cell lines, but is distributed in both cytoplasm and nucleus in 293T cells, demonstrating cell-line-dependent subcellular localization of PSMA7. Eukaryotic expression of DsRed1-XAPC7 fusion protein, fluorescence microscopy in three cell lines Xi bao yu fen zi mian yi xue za zhi (Chinese journal of cellular and molecular immunology) Low 21557907
2025 Melittin suppresses NSCLC cell metastasis by targeting USP10 (a deubiquitinase) and promoting RNF20-mediated ubiquitination and degradation of PSMA7. Co-IP experiments confirmed that PSMA7 interacts with both USP10 and RNF20. PSMA7 overexpression reversed the inhibitory effect of melittin on NSCLC metastasis in vitro, placing PSMA7 downstream of the USP10/RNF20 ubiquitination axis in EMT regulation. Co-immunoprecipitation, proteomics, cycloheximide chase, MG132 proteasome inhibitor assay, PSMA7 overexpression rescue, Transwell/wound healing migration assays, in vivo metastasis model Journal of translational medicine Medium 41254650
2025 CRISPR screening in zebrafish embryos identified PSMA7 as part of a proteasome factor subnetwork (with POMP, PSMA6, PSMD3, PSMD6) required for heart development, based on protein-protein interaction network analysis and functional CRISPR screening. Systems genetics (PPI network analysis), CRISPR-based screening in zebrafish embryos bioRxivpreprint Low

Source papers

Stage 0 corpus · 89 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease. Protein & cell 113 28523434
2017 Flow Dynamics and HSPC Homing in Bone Marrow Microvessels. Cell reports 108 28199850
2021 Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Developmental cell 93 33651979
2020 Mechanical Properties Determination of DMPC, DPPC, DSPC, and HSPC Solid-Ordered Bilayers. Langmuir : the ACS journal of surfaces and colloids 87 32176506
2021 In vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice. Blood advances 79 33620431
2009 Negative regulation of MAVS-mediated innate immune response by PSMA7. Journal of immunology (Baltimore, Md. : 1950) 77 19734229
2004 The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. The Journal of biological chemistry 64 14998988
2001 Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. FEBS letters 60 11389899
2001 Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. Molecular and cellular biology 55 11713272
2016 DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization. Cell stem cell 50 27641306
2016 The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell stem cell 49 27424782
2006 Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. Molecular cell 48 16678104
2009 Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics. AAPS PharmSciTech 41 19629709
2008 The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. Oncology reports 41 18202793
2016 Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia. Cancer research 38 26837759
2017 Bone marrow niche-mimetics modulate HSPC function via integrin signaling. Scientific reports 37 28566689
2015 c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit. Cell reports 35 25620702
2015 Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. eLife 33 25714926
2020 Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source. Frontiers in immunology 32 33193358
2016 p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. Blood 32 26932803
2021 Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood 30 32756943
2018 Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating. Blood 28 29453290
2022 Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis. Molecular metabolism 27 35562083
2017 Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation. The Journal of experimental medicine 27 29141868
2021 Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma. Molecular cancer research : MCR 26 33753553
2009 PSMA7, a potential biomarker of diseases. Protein and peptide letters 26 19442227
2009 Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. Experimental cell research 25 19362550
2009 Depletion of the proteasome subunit PSMA7 inhibits colorectal cancer cell tumorigenicity and migration. Oncology reports 25 19787246
2013 PSMA7 directly interacts with NOD1 and regulates its function. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 23 23839082
2020 Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes. Diabetes 22 32345753
2016 Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization. Blood 18 27365422
2025 Development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment. Blood advances 17 39471483
2018 Effects of shRNA-mediated silencing of PSMA7 on cell proliferation and vascular endothelial growth factor expression via the ubiquitin-proteasome pathway in cervical cancer. Journal of cellular physiology 17 29247526
2018 Novel autoantibodies against the proteasome subunit PSMA7 in amyotrophic lateral sclerosis. Journal of neuroimmunology 17 30390597
2015 Zebrafish embryonic stromal trunk (ZEST) cells support hematopoietic stem and progenitor cell (HSPC) proliferation, survival, and differentiation. Experimental hematology 17 26391449
2023 Selective Cellular Uptake and Cytotoxicity of Curcumin-encapsulated SPC and HSPC Liposome Nanoparticles on Human Bladder Cancer Cells. Current pharmaceutical design 16 36999712
2023 Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England) 16 37227070
2023 Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental cell 15 36693371
2020 Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 15 33069969
2024 BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate. Cell stem cell 14 39642886
2023 ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice. Blood advances 14 37522715
2017 Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. Molecular therapy. Methods & clinical development 14 29322065
2023 Single-cell time series analysis reveals the dynamics of HSPC response to inflammation. Life science alliance 12 38110222
2016 Inflammatory signals in HSPC development and homeostasis: Too much of a good thing? Experimental hematology 12 27423816
2025 Targeting triple-negative breast cancer using cord-blood CD34⁺ HSPC-derived mesothelin-specific CAR-NKT cells with potent antitumor activity. Journal of hematology & oncology 11 41077583
2012 PSMA7 inhibits the tumorigenicity of A549 human lung adenocarcinoma cells. Molecular and cellular biochemistry 11 22584585
2008 A pivotal role of activation of complement cascade (CC) in mobilization of hematopoietic stem/progenitor cells (HSPC). Advances in experimental medicine and biology 11 19025113
2025 Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood 10 40089994
2024 Fetal hepatocytes protect the HSPC genome via fetuin-A. Nature 10 39633051
2021 EZH1/2 Inhibitors Favor ILC3 Development from Human HSPC-CD34+ Cells. Cancers 10 33467134
2023 TGFβ Inhibitor A83-01 Enhances Murine HSPC Expansion for Gene Therapy. Cells 7 37566057
2021 Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production. Developmental cell 7 33689767
2005 Functional analyses and interaction of the XAPC7 proteasome subunit with Rab7. Methods in enzymology 7 16473627
2020 The clonal repopulation of HSPC gene modified with anti-HIV-1 RNAi is not affected by preexisting HIV-1 infection. Science advances 6 32766447
2024 Heterologous HSPC Transplantation Rescues Neuroinflammation and Ameliorates Peripheral Manifestations in the Mouse Model of Lysosomal Transmembrane Enzyme Deficiency, MPS IIIC. Cells 5 38786099
2025 Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America 4 40112113
2025 IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion. eLife 3 41396163
2024 Bone marrow CD8+ Trm cells induced by IL-15 and CD16+ monocytes contribute to HSPC destruction in human severe aplastic anemia. Clinical immunology (Orlando, Fla.) 3 38636890
2023 PSMA7 promotes the malignant proliferation of esophageal cancer. Heliyon 3 38173490
2020 Competitive sgRNA Screen Identifies p38 MAPK as a Druggable Target to Improve HSPC Engraftment. Cells 3 33003308
2008 [High expression of proteasome subunit PSMA7 in colorectal cancer is significantly correlated with liver metastasis]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 3 19062718
2025 Preparation, physicochemical evaluation and in vitro toxicity studies of HSPC and HSPC:DMPC stigmasterol-loaded liposomes. Journal of liposome research 2 40433887
2024 In vivo and in vitro effects of cord blood hematopoietic stem and progenitor cell (HSPC) expansion using valproic acid and/or nicotinamide. Current research in translational medicine 2 38447268
2023 MSC and HSPC Coculture: Mimicking Ex Vivo Bone Marrow Niche. Methods in molecular biology (Clifton, N.J.) 2 36255702
2021 Using a new HSPC senescence model in vitro to explore the mechanism of cellular memory in aging HSPCs. Stem cell research & therapy 2 34365970
2021 Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias. Stem cell research & therapy 2 34620229
2019 Intravital Imaging of Blood Flow and HSPC Homing in Bone Marrow Microvessels. Methods in molecular biology (Clifton, N.J.) 2 31197772
2012 Greasing the way: the ABCs of HSPC efflux from the marrow. Cell stem cell 2 22862939
2025 IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion. bioRxiv : the preprint server for biology 1 39868131
2025 Anti-HIV-1 HSPC-based gene therapy with safety kill switch to defend against and attack HIV-1 infection. Molecular therapy. Methods & clinical development 1 40503012
2025 Characterization of human CD34+ HSPC-derived neutrophils with limited myeloid-derived immunosuppressive cell activity. iScience 1 41054507
2025 Exploring MSC and HSPC interactions: new frontiers in hematopoiesis and transplant medicine. Stem cell research & therapy 1 41250227
2024 Reprogramming of 3D genome structure underlying HSPC development in zebrafish. Stem cell research & therapy 1 38886858
2018 Generation of BMEC Lines and in vitro BMEC-HSPC Co-culture Assays. Bio-protocol 1 34532536
2026 Clonal dynamics, tolerance, and adverse events after CD45-ADC-conditioned autologous HSPC transplantation in macaques. Blood advances 0 41592287
2026 Metabolic and epigenetic interplay in HSPC specification: A balance between extrinsic and intrinsic cues. iScience 0 41816285
2026 Multi-omic profiling converges on proteasome subunits PSMA7/PSMB2 as targets of the sepsis-protective agent Handelin. Frontiers in immunology 0 41939900
2026 Mechanistic and AI-assisted evaluation of paclitaxel-loaded HSPC liposomes for targeted breast cancer therapy. Naunyn-Schmiedeberg's archives of pharmacology 0 42047769
2026 Metabolic Profiling and Perturbations of Human CD34+ Hematopoietic Stem and Progenitors to Regulate HSPC Function. Blood advances 0 42090579
2026 tRNA m1A modification ensures HSPC production via modulating Nrf1 translation in zebrafish. EMBO reports 0 42204347
2025 Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue. Development (Cambridge, England) 0 39620979
2025 Genetic instability in HSPC subpopulations of umbilical cord blood from patients with childhood acute lymphoblastic leukemia. Scientific reports 0 40089517
2025 Melittin inhibits NSCLC metastasis by targeting USP10 and promoting RNF20-mediated ubiquitination and degradation of PSMA7. Journal of translational medicine 0 41254650
2025 HSPC-like blasts in acute lymphoblastic leukemia: biology and therapeutic opportunities. Trends in cancer 0 41436318
2024 Pan-caner analysis identifies PSMA7 as a targets for amplification at 20q13.33 in tumorigenesis. Scientific reports 0 38321088
2024 Anti-HIV-1 HSPC-based gene therapy with safety kill switch to defend against and attack HIV-1 infection. bioRxiv : the preprint server for biology 0 39605384
2011 [Construction of recombinant eukaryotic expression vector pDsRed1-C3/XAPC7 and cellular localization of XAPC7 protein in different cell lines]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 0 21557907
2011 [Microbial diversity in sediments of core HS-PC 500 from Shenhu Area, northern South China Sea]. Wei sheng wu xue bao = Acta microbiologica Sinica 0 22043788
2003 [Studies on the homing-related adhesion activities of UCB HSPC in short-term ex vivo expansion]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 0 12697097

Missed literature

Know a paper Affinage missed for PSMA7? Flag it for the maintainers and the community.

No submissions yet.