Affinage

PSMA7

Proteasome subunit alpha type-7 · UniProt O14818

Round 2 corrected
Length
248 aa
Mass
27.9 kDa
Annotated
2026-04-28
130 papers in source corpus 12 papers cited in narrative 12 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PSMA7 (alpha4/XAPC7) is a structural subunit of the 20S proteasome core particle that contributes to ubiquitin-dependent proteolysis and whose own abundance is tightly regulated by c-Abl/Arg-mediated phosphorylation at Y106 and Y153, which antagonizes BRCA1-dependent ubiquitination and proteasomal auto-degradation of PSMA7, thereby tuning cellular proteasome levels under basal and oxidative-stress conditions (PMID:25620702, PMID:16678104). Beyond its canonical role in proteostasis, PSMA7 negatively regulates innate immune signaling by binding MAVS to promote its degradation and suppress RIG-I–dependent IFN-β production (PMID:19734229), and by binding NOD1 to direct its proteasome-dependent turnover, attenuating NF-κB activation and apoptosis (PMID:23839082). PSMA7 also interacts with Rab7 on late endosomes to negatively regulate EGFR endocytic trafficking (PMID:14998988), cooperates with EMAP-II to accelerate HIF-1α degradation under hypoxia (PMID:11389899, PMID:19362550), and is specifically required for HCV IRES-mediated translation (PMID:11713272).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1996 High

    Establishing PSMA7 as a core component of the 20S proteasome resolved the identity and enzymatic mechanism of the particle's alpha-ring subunits, showing that the 20S core uses threonine-based peptidase activities and assembles with the 19S regulator to form the 26S proteasome.

    Evidence Biochemical purification, peptidase activity assays, and structural characterization of proteasome complexes

    PMID:8811196

    Open questions at the time
    • Role of individual alpha subunits versus the assembled ring in substrate recognition was not resolved
    • Post-translational regulation of PSMA7 itself was unknown
  2. 2001 Medium

    Discovery that PSMA7 physically interacts with HIF-1α and inhibits its transactivation, and that PSMA7 is required for HCV IRES-mediated translation, revealed non-canonical functions for a proteasome subunit beyond bulk proteolysis.

    Evidence Yeast two-hybrid, co-immunoprecipitation, transactivation reporters for HIF-1α; ribozyme knockdown and bicistronic IRES reporters in Huh7 cells for HCV IRES

    PMID:11389899 PMID:11713272

    Open questions at the time
    • Mechanism linking PSMA7 to HCV IRES translation remained unclear
    • Whether PSMA7–HIF-1α interaction operates independently of assembled proteasome was not determined
    • No in vivo validation for HCV IRES finding
  3. 2004 High

    Identifying PSMA7 as a Rab7-binding partner recruited to multivesicular late endosomes established a proteasome-subunit-mediated negative regulatory step in late endocytic trafficking of receptors such as EGFR.

    Evidence Reciprocal co-immunoprecipitation, domain mapping, subcellular fractionation, endocytic transport assays with Rab7 rescue

    PMID:14998988

    Open questions at the time
    • Whether PSMA7 acts on Rab7 as part of an assembled proteasome or as a free subunit was not resolved
    • Physiological contexts requiring PSMA7–Rab7 interaction (e.g., growth factor signaling) were unexplored
  4. 2006 High

    Demonstrating that c-Abl/Arg phosphorylate PSMA7 at Y153 and that this modification compromises proteasome activity and cell-cycle progression revealed the first signaling-dependent post-translational control of a proteasome alpha subunit.

    Evidence In vitro kinase assay, Y153F mutagenesis, proteasome activity assays, cell cycle analysis

    PMID:16678104

    Open questions at the time
    • How Y153 phosphorylation structurally impairs proteasome activity was unknown
    • Relationship between Y153 and other phosphorylation sites on PSMA7 was not examined
  5. 2009 High

    Three studies collectively expanded PSMA7's non-canonical roles: PSMA7 binds MAVS and promotes its degradation to suppress RIG-I/IFN-β signaling; EMAP-II engagement promotes PSMA7-dependent HIF-1α degradation under hypoxia; and PSMA7 depletion reduces tumorigenicity in colorectal cancer cells partly through CD44.

    Evidence Reciprocal co-IP and GST pulldown for MAVS, gain/loss-of-function IFN-β and NF-κB reporters, viral infection assays; co-IP and HIF-1α degradation assays for EMAP-II; shRNA xenograft and invasion assays for tumor phenotype

    PMID:19362550 PMID:19734229 PMID:19787246

    Open questions at the time
    • Whether PSMA7–MAVS interaction is direct or occurs within an assembled proteasome was not distinguished
    • Mechanism by which PSMA7 depletion reduces CD44 was correlative
    • In vivo immune phenotype of PSMA7 loss was not assessed
  6. 2013 High

    Identification of NOD1 as a direct PSMA7 interactor whose proteasome-dependent degradation is promoted by PSMA7 broadened the gene's role in innate immunity from antiviral (MAVS) to antibacterial (NOD1) pathways.

    Evidence Yeast two-hybrid, co-immunoprecipitation, GST pulldown, ubiquitin assays, NF-κB reporter, apoptosis assays, siRNA knockdown

    PMID:23839082

    Open questions at the time
    • E3 ligase responsible for NOD1 ubiquitination downstream of PSMA7 was not identified
    • Physiological relevance in pathogen challenge models was not tested
  7. 2015 High

    Elucidating the full regulatory circuit — BRCA1 ubiquitinates PSMA7 for proteasomal degradation, and c-Abl/Arg phosphorylation at Y106 antagonizes this — established how cells tune total proteasome abundance and explained compensatory proteasome upregulation during oxidative stress.

    Evidence Ubiquitination assays identifying BRCA1 as E3, Y106 mutagenesis, c-Abl/Arg RNAi and knockout, proteasome abundance quantification, oxidative stress experiments

    PMID:25620702

    Open questions at the time
    • Whether other E3 ligases contribute to PSMA7 turnover was not addressed
    • Structural basis for how Y106 phosphorylation blocks BRCA1 recognition is unknown
  8. 2021 Medium

    Placing PSMA7 within a UCHL1–PSMA7–APEH proteostasis axis in ovarian cancer showed that upstream deubiquitinase activity controls PSMA7 expression, linking PSMA7 to mTORC1 signaling and the unfolded protein response.

    Evidence siRNA/shRNA knockdown, proteasome activity assays, Western blot for polyubiquitinated proteins, mTORC1 activity assay, xenograft model

    PMID:33753553

    Open questions at the time
    • Whether UCHL1 directly deubiquitinates PSMA7 or acts indirectly through transcriptional regulation was not resolved
    • Generalizability beyond high-grade serous ovarian carcinoma is untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether the non-canonical functions of PSMA7 (MAVS/NOD1 degradation, Rab7-mediated endosomal regulation, HCV IRES translation) are executed by free PSMA7 subunits or by PSMA7 within assembled proteasome complexes, and no structural model exists for PSMA7 interactions with its non-proteasomal partners.
  • Free-subunit versus assembled-proteasome distinction for non-canonical activities
  • Structural basis of PSMA7 interactions with MAVS, NOD1, and Rab7
  • In vivo immune and endosomal phenotypes of conditional PSMA7 loss

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 4 GO:0098772 molecular function regulator activity 2 GO:0016787 hydrolase activity 1
Localization
GO:0005829 cytosol 2 GO:0005768 endosome 1
Pathway
R-HSA-392499 Metabolism of proteins 5 R-HSA-1640170 Cell Cycle 2 R-HSA-168256 Immune System 2 R-HSA-8953854 Metabolism of RNA 1 R-HSA-8953897 Cellular responses to stimuli 1
Partners
ABL1ABL2AIMP1BRCA1HIF1AMAVSNOD1RAB7A
Complex memberships
20S proteasome26S proteasome

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 PSMA7 (alpha4 subunit) is a component of the 20S proteasome core complex, which contains multiple peptidase activities functioning through a threonine active-site mechanism; the 20S particle associates with the 19S regulatory complex to form the 26S proteasome that degrades ubiquitinated proteins. Biochemical purification, peptidase activity assays, structural characterization of proteasome complexes Annual review of biochemistry High 8811196
2001 PSMA7 (proteasome alpha4 subunit) interacts specifically with two subdomains of HIF-1alpha and inhibits HIF-1alpha transactivation function under both normoxic and hypoxia-mimicking conditions; this regulation is associated with the proteasome degradation pathway. Yeast two-hybrid, co-immunoprecipitation, transactivation reporter assays FEBS letters Medium 11389899
2001 PSMA7 mRNA is a direct target of a hairpin ribozyme, and ribozyme-mediated knockdown of PSMA7 inhibits HCV IRES-mediated translation but not cap-dependent translation or IRES activity of encephalomyocarditis virus or human rhinovirus; additionally, the proteasome inhibitor MG132 dose-dependently inhibits HCV IRES-mediated translation, implicating PSMA7 specifically in regulating HCV IRES activity. Ribozyme cleavage-based target identification (CASCASE), GCV-resistance reporter assay, bicistronic Renilla-HCV IRES-firefly luciferase reporter in Huh7 cells, pharmacological proteasome inhibition Molecular and cellular biology Medium 11713272
2004 The proteasome alpha-subunit XAPC7 (PSMA7) interacts specifically with Rab7 via its C-terminus (interacting with the N-terminus of Rab7) and is recruited to multivesicular late endosomes through this interaction; overexpression of PSMA7 impairs late endocytic transport of EGFR and another membrane protein, and this is partially rescued by co-expression of wild-type Rab7, establishing a negative regulatory role for PSMA7 in late endocytic trafficking. Co-immunoprecipitation, subcellular fractionation, domain mapping, fluorescence microscopy, endocytic transport assays, Rab7 chimera experiments The Journal of biological chemistry High 14998988
2006 c-Abl and Arg tyrosine kinases associate with and phosphorylate PSMA7 at Tyr-153; this phosphorylation compromises proteasome-dependent proteolysis. Cells expressing the phosphorylation-deficient PSMA7(Y153F) mutant display impaired G1/S transition and S/G2 cell cycle progression. Co-immunoprecipitation, in vitro kinase assay, site-directed mutagenesis (Y153F), cell cycle analysis, proteasome activity assays Molecular cell High 16678104
2009 PSMA7 (alpha4 subunit) associates with MAVS (mitochondrial antiviral signaling protein) both in vivo and in vitro; overexpression of PSMA7 potently inhibits RIG-I and MAVS-mediated IFN-beta promoter activity, reduces endogenous MAVS protein abundance, and siRNA depletion of PSMA7 enhances virus-induced type I IFN production and reduces virus replication. Viral infection transiently increases endogenous PSMA7 protein levels. Co-immunoprecipitation, GST pulldown, IFN-beta promoter luciferase reporter assay, siRNA knockdown, viral infection assay, Western blot for MAVS levels Journal of immunology (Baltimore, Md. : 1950) High 19734229
2009 EMAP-II (endothelial monocyte activating polypeptide-II) binds to cell-surface alpha5beta1 integrin, is internalized, and then interacts with cytoplasmic PSMA7; this interaction with PSMA7 increases HIF-1alpha degradation under hypoxic conditions, inhibiting HIF-1alpha-mediated transcriptional activity and angiogenic sprouting of endothelial cells. Co-immunoprecipitation, cellular fractionation, HIF-1alpha degradation assay, HIF-1alpha transcriptional reporter assay, tube formation assay Experimental cell research Medium 19362550
2009 shRNA-mediated depletion of PSMA7 in RKO colorectal cancer cells inhibits anchorage-independent growth, cell invasion and migration, and in vivo tumorigenicity; these effects are associated with suppression of CD44 expression, suggesting PSMA7 promotes tumor progression partly through CD44. shRNA knockdown, anchorage-independent growth assay, invasion/migration assay, xenograft tumor assay, Western blot for CD44 Oncology reports Medium 19787246
2013 PSMA7 directly associates with NOD1 (nucleotide-binding oligomerization domain-containing protein 1), identified by yeast two-hybrid screening and confirmed by co-immunoprecipitation and GST pulldown; PSMA7 downregulates NOD1 protein in a proteasome-dependent manner, and overexpression of PSMA7 inhibits NOD1-mediated apoptosis and NF-κB activation, while PSMA7 knockdown enhances NOD1 activity. Yeast two-hybrid screening, co-immunoprecipitation, GST pulldown, ubiquitin assay, Western blotting, NF-κB reporter assay, apoptosis assay, siRNA knockdown Cellular physiology and biochemistry High 23839082
2015 PSMA7 is itself subject to ubiquitination and proteasomal degradation; BRCA1 functions as the E3 ubiquitin ligase for PSMA7 ubiquitination. Phosphorylation of PSMA7 at Y106 by c-Abl/Arg kinases suppresses BRCA1-mediated ubiquitination and proteasomal degradation of PSMA7, thereby controlling cellular proteasome abundance. Downregulation of PSMA7 via c-Abl/Arg RNAi or knockout reduces overall proteasome abundance and increases sensitivity to proteasome inhibition. Under oxidative stress, c-Abl-mediated upregulation of PSMA7/proteasome levels compensates for ROS-induced proteasomal activity impairment. Ubiquitination assay, E3 ligase identification (BRCA1), site-directed mutagenesis (Y106), RNAi knockdown, c-abl/arg knockout cells, proteasome activity assays, proteasome abundance quantification, oxidative stress experiments Cell reports High 25620702
2018 shRNA-mediated silencing of PSMA7 in cervical cancer SiHa cells decreases proteasome activity, reduces ubiquitin and VEGF expression, increases p27 expression, causes G0/G1 cell cycle arrest, and promotes apoptosis, demonstrating that PSMA7 regulates cell proliferation and VEGF expression through the ubiquitin-proteasome pathway. shRNA knockdown, MTT proliferation assay, flow cytometry (cell cycle and apoptosis), immunofluorescence (20S proteasome activity), RT-qPCR, Western blot, in situ hybridization Journal of cellular physiology Medium 29247526
2021 UCHL1 (deubiquitinase) maintains protein homeostasis in high-grade serous ovarian carcinoma through a PSMA7-APEH-proteasome axis: UCHL1 silencing reduces PSMA7 and APEH expression, causing decreased proteasome activity, impaired protein degradation, accumulation of polyubiquitinated proteins, attenuation of mTORC1 activity, and induction of terminal unfolded protein response. siRNA/shRNA knockdown, transcriptional profiling, proteasome activity assay, Western blot for polyubiquitinated proteins, mTORC1 activity assay, xenograft mouse model Molecular cancer research : MCR Medium 33753553

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Structure and functions of the 20S and 26S proteasomes. Annual review of biochemistry 2108 8811196
2002 Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 1924 12167863
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annual review of biochemistry 1398 19489727
2011 Systematic and quantitative assessment of the ubiquitin-modified proteome. Molecular cell 1334 21906983
2003 Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature 1236 12808466
2003 DNA deamination mediates innate immunity to retroviral infection. Cell 1150 12809610
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2003 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science (New York, N.Y.) 1006 14564014
2005 Nucleolar proteome dynamics. Nature 934 15635413
2003 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Nature 912 12808465
2013 Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature 870 23503661
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Nature medicine 798 14528300
2008 Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 787 18854154
2003 Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell 763 12859895
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2011 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Molecular & cellular proteomics : MCP 749 21890473
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2003 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Nature medicine 679 14528301
2015 Gene essentiality and synthetic lethality in haploid human cells. Science (New York, N.Y.) 657 26472760
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2003 HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Molecular cell 607 14527406
2003 Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science (New York, N.Y.) 570 12750511
2011 Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell 507 21565611
2007 Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer research 167 17308093
2017 Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease. Protein & cell 111 28523434
1991 Expression of gap junction genes in astrocytes and C6 glioma cells. Neuroscience letters 110 1650934
2017 Flow Dynamics and HSPC Homing in Bone Marrow Microvessels. Cell reports 106 28199850
2021 Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Developmental cell 90 33651979
2003 High-level expression of recombinant IgG in the human cell line per.c6. Biotechnology progress 86 12573020
2020 Mechanical Properties Determination of DMPC, DPPC, DSPC, and HSPC Solid-Ordered Bilayers. Langmuir : the ACS journal of surfaces and colloids 84 32176506
2021 In vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice. Blood advances 77 33620431
2009 Negative regulation of MAVS-mediated innate immune response by PSMA7. Journal of immunology (Baltimore, Md. : 1950) 76 19734229
2004 Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons. Experimental neurology 73 15081589
2004 Nanotopographical guidance of C6 glioma cell alignment and oriented growth. Biomaterials 71 15046911
1999 Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells. Brain research 69 10350526
2002 Functional relationship of cytochrome c(6) and plastocyanin in Arabidopsis. Nature 66 12037572
2004 The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. The Journal of biological chemistry 64 14998988
2009 Pannexin2 as a novel growth regulator in C6 glioma cells. Oncogene 63 19749789
2001 Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. FEBS letters 60 11389899
2001 Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. Molecular and cellular biology 55 11713272
2009 Expression of transient receptor potential C6 channels in human lung macrophages. American journal of respiratory cell and molecular biology 54 19843708
2016 The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell stem cell 48 27424782
2006 Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. Molecular cell 48 16678104
1997 Osmosignalling in C6 glioma cells. FEBS letters 48 9001390
2006 Combination celecoxib and temozolomide in C6 rat glioma orthotopic model. Oncology reports 45 16328028
1993 Structure of the human C6 gene. Biochemistry 42 8512929
2009 Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics. AAPS PharmSciTech 41 19629709
2008 The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. Oncology reports 41 18202793
1986 Responses in astrocytic C6 glioma cells to ethanol and dibutyryl cyclic AMP. Brain research 41 2868787
1986 Persistent infection of Aedes albopictus C6/36 cells by Bunyamwera virus. Virology 39 3952984
2018 Synergistic Anticancer Effects of Formononetin and Temozolomide on Glioma C6 Cells. Biological & pharmaceutical bulletin 38 29848900
2017 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. Neurotoxicology 38 28167099
2001 Reduction in the local expression of complement component 6 (C6) and 7 (C7) mRNAs in oesophageal carcinoma. European journal of cancer (Oxford, England : 1990) 38 11378347
2017 Bone marrow niche-mimetics modulate HSPC function via integrin signaling. Scientific reports 37 28566689
2016 Silencing homeobox C6 inhibits colorectal cancer cell proliferation. Oncotarget 36 27081081
2020 Nonspecific phospholipase C6 increases seed oil production in oilseed Brassicaceae plants. The New phytologist 33 32176333
2015 c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit. Cell reports 33 25620702
2002 NO-mediated chemoresistance in C6 glioma cells. Annals of the New York Academy of Sciences 33 12076959
2015 Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. eLife 32 25714926
2005 Caveolin isoform expression during differentiation of C6 glioma cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 32 16135403
1996 Pathway of C6-NBD-Ceramide on the host cell infected with Toxoplasma gondii. Cell structure and function 32 8726473
2023 TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6. Nature 31 37558876
2020 Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source. Frontiers in immunology 31 33193358
2012 Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells. Journal of pineal research 31 22225631
2011 p53 in trichostatin A induced C6 glioma cell death. Biochimica et biophysica acta 30 21376104
1998 Cyclic AMP regulates potassium channel expression in C6 glioma by destabilizing Kv1.1 mRNA. Proceedings of the National Academy of Sciences of the United States of America 30 9636212
2021 Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood 28 32756943
2018 Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating. Blood 27 29453290
2002 The interactions of cyanobacterial cytochrome c6 and cytochrome f, characterized by NMR. The Journal of biological chemistry 27 12356767
1977 Nonlinkage between C6 and chromosome 6 markers. Human genetics 27 885533
2022 Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis. Molecular metabolism 26 35562083
2021 Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma. Molecular cancer research : MCR 26 33753553
2017 Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation. The Journal of experimental medicine 26 29141868
2009 PSMA7, a potential biomarker of diseases. Protein and peptide letters 26 19442227
1995 Suramin inhibits C6 glioma-induced angiogenesis in vitro. Journal of cellular biochemistry 26 7545684
2015 Introduction of Methyl Groups at C2 and C6 Positions Enhances the Antiangiogenesis Activity of Curcumin. Scientific reports 25 26391485
2009 Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. Experimental cell research 25 19362550
2009 Depletion of the proteasome subunit PSMA7 inhibits colorectal cancer cell tumorigenicity and migration. Oncology reports 25 19787246
1992 Enhancement of radiosensitivity by tamoxifen in C6 glioma cells. Neurosurgery 25 1407459
2012 Production and characterization of a novel human recombinant alpha-1-antitrypsin in PER.C6 cells. Journal of biotechnology 24 23036927
2019 Effects of photobiomodulation on mitochondria of brain, muscle, and C6 astroglioma cells. Medical engineering & physics 23 31303375
2013 Riluzole increases glutamate uptake by cultured C6 astroglial cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 23 23777615
2013 PSMA7 directly interacts with NOD1 and regulates its function. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 23 23839082
2005 Thallium acetate induces C6 glioma cell apoptosis. Annals of the New York Academy of Sciences 23 15965099
2004 Differential role of ERK in cAMP-induced Nurr1 expression in N2A and C6 cells. Neuroreport 23 15106839
2020 Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes. Diabetes 22 32345753
2007 Epicatechin gallate increases glutamate uptake and S100B secretion in C6 cell lineage. Molecular and cellular biochemistry 21 18066651
1995 DNA polymorphisms of the complement C6 and C7 genes. Annals of human genetics 21 7625764
2020 Requirement of Complement C6 for Intact Innate Immune Responses in Mice. Journal of immunology (Baltimore, Md. : 1950) 20 32444389
2000 Differential fibronectin expression in activated C6 glial cells treated with ethanol. Molecular pharmacology 19 11093767
1992 Expression of multiple integrins and extracellular matrix components by C6 glioma cells. Journal of neuroscience research 19 1640499
2021 Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress. International journal of molecular sciences 18 33546324
2016 Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization. Blood 18 27365422
2013 SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA. Oncology reports 18 24173428
2012 Effects of chronic cocaine in rat C6 astroglial cells. International journal of molecular medicine 18 22735768
1997 Characterization of complement C6 deficiency in a PVG/c rat strain. Clinical and experimental immunology 18 9276537
1995 Complement component C6 and C7 haplotypes associated with deficiencies of C6. Annals of human genetics 18 7625765
2018 Novel autoantibodies against the proteasome subunit PSMA7 in amyotrophic lateral sclerosis. Journal of neuroimmunology 17 30390597
2017 MicroRNA-124 inhibits the proliferation of C6 glioma cells by targeting Smad4. International journal of molecular medicine 17 28791348
1999 Hox C6 expression during development and regeneration of forelimbs in larval Notophthalmus viridescens. Development genes and evolution 17 10370113
2025 Development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment. Blood advances 16 39471483
2020 Reference and Ghost Proteins Identification in Rat C6 Glioma Extracellular Vesicles. iScience 16 32334413
2018 Effects of shRNA-mediated silencing of PSMA7 on cell proliferation and vascular endothelial growth factor expression via the ubiquitin-proteasome pathway in cervical cancer. Journal of cellular physiology 16 29247526
2007 Adenosine uptake-dependent C6 cell growth inhibition. European journal of pharmacology 16 17878054
2023 Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England) 15 37227070
2020 Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 15 33069969
2019 Perampanel attenuates epileptiform phenotype in C6 glioma. Neuroscience letters 15 31734290
2019 Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis. Pediatrics 15 31836615
2016 Regulation of C6 glioma cell migration by thymol. Oncology letters 15 27073528
1995 Clearance and metabolism of arachidonic acid by C6 glioma cells and astrocytes. Neurochemical research 15 8789607
2023 Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental cell 14 36693371
2023 Selective Cellular Uptake and Cytotoxicity of Curcumin-encapsulated SPC and HSPC Liposome Nanoparticles on Human Bladder Cancer Cells. Current pharmaceutical design 14 36999712
2020 FaMYB9 is involved in the regulation of C6 volatile biosynthesis in strawberry. Plant science : an international journal of experimental plant biology 14 32081270
2005 Quantification of residual host cell DNA in adenoviral vectors produced on PER.C6 cells. Human gene therapy 14 15812234
1990 Effects of trifluoroacetic acid, a halothane metabolite, on C6 glioma cells. Journal of toxicology and environmental health 14 2213926
2024 BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate. Cell stem cell 13 39642886
1995 Cell adhesion molecules acting between C6 glioma and endothelial cells. Journal of neuro-oncology 13 7562005
1979 Microtubule protein preparations from C6 glial cells and their spontaneous polymer formation. The Journal of cell biology 13 457759
2024 Palmitate Compromises C6 Astrocytic Cell Viability and Mitochondrial Function. Metabolites 12 38535321
2023 ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice. Blood advances 12 37522715
2023 Single-cell time series analysis reveals the dynamics of HSPC response to inflammation. Life science alliance 12 38110222
2021 Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6-Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6-Methyltransferase. Angewandte Chemie (International ed. in English) 12 34626048
2016 Inflammatory signals in HSPC development and homeostasis: Too much of a good thing? Experimental hematology 12 27423816