Affinage

PRKAA1

5'-AMP-activated protein kinase catalytic subunit alpha-1 · UniProt Q13131

Length
559 aa
Mass
64.0 kDa
Annotated
2026-06-10
39 papers in source corpus 15 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PRKAA1 encodes the catalytic α1 subunit of AMPK, an energy-sensing kinase that couples cellular metabolic state to autophagy, mitochondrial quality control, lipid handling, and cell fate across multiple tissues (PMID:24988326, PMID:26029847). A central effector arm is phosphorylation of ULK1 at Ser555 to nucleate the ULK1–BECN1–PtdIns3K complex and drive autophagic flux; this axis is required for mitochondrial clearance (mitophagy) during erythrocyte maturation, where its loss causes accumulation of damaged mitochondria, elevated ROS, and hemolytic anemia (PMID:24988326), and is engaged downstream of CAMKK2 and the P2RY6 receptor to promote CSF1-induced monocyte-to-macrophage differentiation (PMID:26029847). PRKAA1 phosphorylates and inactivates acetyl-CoA carboxylase as part of metabolic adaptation (PMID:20876741), and more broadly governs glucose and lipid metabolism: it drives aerobic glycolysis in endothelial cells via GLUT1/SLC2A1 to maintain barrier integrity and protect against atherosclerosis under disturbed flow (PMID:30405100), supports macrophage metabolic fitness and recruitment to metabolic tissues (PMID:33511118), and restrains intramyocellular lipid accumulation and mTOR signaling in skeletal muscle (PMID:29288408). Through an acetyl-CoA/ATP-citrate-lyase/p300 axis it also feeds histone acetylation and inflammatory gene transcription in endothelium (PMID:34796475). PRKAA1 additionally signals through PINK1/Parkin-dependent mitophagy in stressed neurons (PMID:36924562) and through JNK1 and Akt to promote proliferation and suppress apoptosis in gastric cancer (PMID:31558185). PRKAA1 abundance is set post-transcriptionally by FTO-mediated m6A demethylation of its 3'-UTR, which protects the transcript from YTHDF2-dependent degradation (PMID:36305690), and by targeting miRNAs including miR-181a, which represses PRKAA1 to modulate hippocampal memory formation (PMID:28814760).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2010 Medium

    Established that PRKAA1/2 acts as a stress-responsive switch in trophoblast stem cells, distinguishing low-stress metabolic adaptation from high-stress differentiation.

    Evidence Pharmacological AMPK modulation, proteasome inhibition, and PRKAA1/2 knockdown with phospho-ACC and ID2 readouts in mouse TSCs, including benzo(a)pyrene exposure

    PMID:20422711 PMID:20876741

    Open questions at the time
    • Direct kinase-substrate relationship to ID2 loss not demonstrated
    • α1 versus α2 contribution not separated
    • single lab
  2. 2010 Low

    First indication that PRKAA1 activation confers cytoprotection against an environmental toxicant, hinting at a stress-survival role.

    Evidence siRNA knockdown and AICAR activation with viability readout in HEK293 cells under methylmercury exposure

    PMID:20686348

    Open questions at the time
    • Single pharmacological/RNAi approach with no defined downstream pathway
    • AICAR is not PRKAA1-specific
    • not validated in primary cells
  3. 2014 High

    Defined the molecular mechanism by which PRKAA1 drives mitophagy, showing it phosphorylates ULK1 Ser555 to assemble the autophagy-initiation complex required for clearing mitochondria during erythrocyte maturation.

    Evidence Prkaa1 knockout mice, ULK1 Ser555 phosphorylation assays, complex-formation and autophagic-flux measurement, ROS quantification, bone marrow transplantation, rapamycin/Mito-tempol rescue

    PMID:24988326

    Open questions at the time
    • Whether Ser555 phosphorylation is direct versus indirect not formally resolved by in vitro kinase assay
    • generalization beyond erythroid lineage untested here
  4. 2014 Medium

    Placed PRKAA1 activation upstream of and independent from autophagy during exercise, dissociating its sensor function from its autophagic output in skeletal muscle.

    Evidence Inducible muscle-specific Atg7 knockout mice with exercise performance, PRKAA1 activity, and mitochondrial function assays

    PMID:25483961

    Open questions at the time
    • Negative result regarding PRKAA1 dependence on autophagy
    • does not address PRKAA1 substrates during exercise
    • single lab
  5. 2015 High

    Ordered an upstream-to-downstream signaling cascade, showing PRKAA1 transmits CAMKK2 and P2RY6 receptor input to ULK1-dependent autophagy to drive human monocyte differentiation.

    Evidence siRNA knockdown, pharmacological inhibition, and epistasis in primary human monocytes and CMML patient cells with P2RY6 ligand rescue

    PMID:26029847

    Open questions at the time
    • Direct biochemical link between P2RY6/CAMKK2 and PRKAA1 activation not shown
    • structural basis of pathway coupling unknown
  6. 2017 Medium

    Identified PRKAA1 as a post-transcriptionally regulated node in memory, repressed by miR-181a in the hippocampus.

    Evidence Luciferase reporter validation, in vivo miR-181a agomir/antagomir injection with AICAR/compound C rescue, and behavioral memory assays in mouse dorsal hippocampus

    PMID:28814760

    Open questions at the time
    • Downstream PRKAA1 substrates in neurons not defined
    • AICAR/compound C are not PRKAA1-selective
    • single lab
  7. 2017 Medium

    Showed PRKAA1 restrains lipid storage and mTOR signaling in skeletal muscle under dietary lipid load.

    Evidence Muscle-specific Prkaa1 knockout mice on high-fat diet with lipid quantification, gene expression, and mTOR signaling assays

    PMID:29288408

    Open questions at the time
    • Direct substrate driving lipid phenotype not identified
    • redundancy with α2 not tested
    • single lab
  8. 2018 High

    Established a protective metabolic role for endothelial PRKAA1, driving GLUT1-dependent glycolysis that preserves endothelial integrity and limits atherosclerosis under disturbed flow.

    Evidence Endothelial-specific Prkaa1 knockout in hyperlipidemic mice with Slc2a1 overexpression rescue, siRNA in human ECs, and in vitro disturbed-flow models

    PMID:30405100

    Open questions at the time
    • Mechanism by which PRKAA1 upregulates GLUT1 not detailed
    • flow-sensing input upstream of PRKAA1 unresolved
  9. 2019 Medium

    Implicated PRKAA1 as a pro-proliferative, anti-apoptotic kinase in gastric cancer acting through JNK1 and Akt.

    Evidence shRNA knockdown, compound C, JNK1/Akt inhibitors, overexpression rescue, and xenografts with Western blot

    PMID:31558185

    Open questions at the time
    • Whether JNK1/Akt activation is direct is unresolved
    • context-dependence versus tumor-suppressive AMPK roles not reconciled
    • single lab
  10. 2021 Medium

    Revealed an unexpected pro-inflammatory, disease-promoting facet of PRKAA1 in endothelium and myeloid cells, linking its metabolic activity to acetyl-CoA-dependent epigenetic and recruitment programs.

    Evidence EC-specific and myeloid-specific Prkaa1 knockout mice on high-fat/Western diet, metabolic flux, gene expression, and flow cytometry with acetyl-CoA/ATP-citrate-lyase/p300 readouts

    PMID:33511118 PMID:34796475

    Open questions at the time
    • Apparent contradiction with the atheroprotective endothelial role (idx 0) not reconciled
    • direct PRKAA1 substrate in the acetyl-CoA axis unknown
    • single lab each
  11. 2022 Medium

    Defined how PRKAA1 protein abundance is set post-transcriptionally, via FTO-mediated m6A demethylation that blocks YTHDF2-dependent transcript decay.

    Evidence m6A RNA immunoprecipitation, YTHDF2 interaction, FTO gain/loss, mRNA stability assays, and glycolysis measurement in gastric cancer cells

    PMID:36305690

    Open questions at the time
    • m6A site mapping resolution limited
    • in vivo relevance of the FTO-PRKAA1 axis untested
    • single lab
  12. 2023 Medium

    Showed PRKAA1 can drive maladaptive PINK1/Parkin mitophagy that promotes neuronal apoptosis under toxicant stress.

    Evidence Rat NaF model and SH-SY5Y cells with phosphoproteomics, Western blot, and dorsomorphin/3-MA pharmacological epistasis

    PMID:36924562

    Open questions at the time
    • Mechanistic link from PRKAA1 to PINK1/Parkin upregulation not defined
    • pharmacological inhibitors lack full specificity
    • single lab
  13. 2024 Medium

    Demonstrated PRKAA1-mediated autophagy as the effector enhancing amyloid-β clearance and dampening NF-κB inflammation in astrocytes when glucose uptake is restricted.

    Evidence Pharmacological glucose-transport inhibition in primary astrocytes with ATP/AMP measurement, PRKAA1 siRNA, autophagy flux, NF-κB translocation, and cytokine ELISA

    PMID:40395536

    Open questions at the time
    • Direct PRKAA1 substrates linking autophagy to NF-κB suppression not identified
    • in vivo amyloid clearance not tested
    • single lab
  14. 2025 Medium

    Extended PRKAA1 function to tissue maintenance, showing its loss in tendon progenitors disrupts ECM organization, accelerates senescence, and causes mechanical decline and ectopic calcification.

    Evidence Conditional Prkaa1 knockout in tendon progenitors with RNA-seq, mechanical testing, senescence immunostaining, ECM adhesion assays, and exercise intervention (preprint)

    Open questions at the time
    • Preprint not yet peer-reviewed
    • molecular substrate linking PRKAA1 to ECM/senescence programs unknown
    • single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PRKAA1 produces opposite outcomes in different contexts—atheroprotective glycolysis versus pro-inflammatory acetyl-CoA signaling, cytoprotective versus apoptotic mitophagy—remains mechanistically unresolved.
  • No unifying framework distinguishing context-specific substrate selection
  • α1 versus α2 subunit-specific functions rarely separated
  • direct in vitro kinase-substrate validation lacking for several reported targets

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 4 GO:0140657 ATP-dependent activity 3 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005829 cytosol 2
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-8953897 Cellular responses to stimuli 3 R-HSA-9612973 Autophagy 3 R-HSA-162582 Signal Transduction 2
Partners
BECN1CAMKK2P2RY6ULK1

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 Endothelial PRKAA1/AMPKα1 drives increased aerobic glycolysis in endothelial cells exposed to disturbed flow; selective deletion of endothelial Prkaa1 reduces glycolysis and accelerates atherosclerotic lesion formation, while rescue via Slc2a1 (GLUT1) overexpression restores glycolysis, endothelial viability, and barrier integrity, reversing susceptibility to atherosclerosis. Endothelial-specific Prkaa1 knockout mice in hyperlipidemic background, Slc2a1 overexpression rescue, siRNA knockdown in human endothelial cells, in vitro disturbed flow models Nature communications High 30405100
2014 PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance (mitophagy) during erythrocyte maturation; Prkaa1 deletion inhibits ULK1 phosphorylation at Ser555, prevents ULK1–BECN1–PtdIns3K complex formation, reduces autophagic flux, causes damaged mitochondrial accumulation, elevated ROS, hemolytic anemia, and splenomegaly. Rapamycin or mitochondria-targeted antioxidant treatment alleviates the phenotype; bone marrow transplantation experiments confirmed the cell-intrinsic nature of the defect. Prkaa1 knockout mice, bone marrow transplantation, ULK1 phosphorylation assays, autophagic flux measurement, ROS quantification, rapamycin and Mito-tempol treatment Autophagy High 24988326
2015 The CAMKK2–PRKAA1–ULK1 signaling pathway is required for CSF1-induced autophagy and human monocyte differentiation into macrophages; PRKAA1 links P2RY6 receptor engagement (activated by UDP) to autophagy induction and monocyte differentiation. siRNA knockdown, pharmacological inhibition, pathway epistasis experiments in primary human monocytes and CMML patient cells Autophagy High 26029847
2014 Acute inhibition of autophagy (muscle-specific Atg7 knockout) in skeletal muscle does not impair physical performance or PRKAA1 activation during exercise, demonstrating that PRKAA1 activation is upstream of and independent of autophagy during exercise; however, autophagy is required for mitochondrial quality control during damaging muscle contraction. Inducible muscle-specific Atg7 knockout mice, exercise performance assays, PRKAA1 activity measurement, mitochondrial function assays Autophagy Medium 25483961
2010 PRKAA1/2 mediates stress-induced proteasome-dependent loss of ID2 protein in trophoblast stem cells (TSCs), promoting differentiation; at low stress levels PRKAA1/2 mediates metabolic adaptation (phosphorylation/inactivation of acetyl-CoA carboxylase) without ID2 loss, while high stress causes irreversible ID2 loss and TSC differentiation. Pharmacological AMPK inhibition/activation, proteasome inhibition, Western blot for ID2 and phospho-ACC in mouse TSCs Reproduction (Cambridge, England) Medium 20876741
2010 Benzo(a)pyrene (BaP) activates PRKAA1/2 and causes PRKAA1/2-dependent ID2 protein loss in trophoblast stem cells in a dose- and time-dependent manner, promoting TSC differentiation at doses corresponding to heavy smoking levels. BaP treatment of mouse TSCs, AMPK activity assays, ID2 Western blot, PRKAA1/2 siRNA knockdown Molecular reproduction and development Medium 20422711
2019 PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activation of JNK1 and Akt signaling pathways; shRNA-mediated PRKAA1 knockdown reduces PCNA and Bcl-2 expression and JNK1/Akt activity, and inactivation of either JNK1 or Akt blocks PRKAA1 overexpression-induced proliferation. shRNA knockdown, AMPK inhibitor (Compound C), signaling pathway inhibitors for JNK1 and Akt, xenograft mouse model, Western blot Oncology research Medium 31558185
2021 Endothelial PRKAA1 knockdown reduces endothelial glycolysis and fatty acid oxidation, decreases acetyl-CoA levels, and suppresses transcription of inflammatory molecules mediated by ATP citrate lyase and histone acetyltransferase p300; EC-specific Prkaa1 knockout unexpectedly alleviates HFD-induced metabolic syndrome including inflammation. EC-specific Prkaa1 knockout mice on HFD, siRNA knockdown in cultured ECs, metabolic flux measurements, gene expression analysis (qRT-PCR), flow cytometry British journal of pharmacology Medium 34796475
2021 Prkaa1 deficiency in myeloid cells downregulates glucose and lipid metabolism genes, compromises macrophage glucose and lipid metabolism, suppresses monocyte/macrophage recruitment to adipose tissue, liver, and arterial walls, and decreases macrophage viability in those tissues, resulting in reduced diet-induced metabolic disorders and atherosclerosis. Myeloid-specific Prkaa1 knockout mice on HFD and Western diet, gene expression profiling, metabolic assays in macrophages Frontiers in cell and developmental biology Medium 33511118
2017 Muscle-specific deletion of Prkaa1 enhances intramyocellular triacylglycerol accumulation under high-fat diet conditions, with upregulation of adipogenic gene expression, downregulation of mitochondrial oxidation genes, hyperlipidemia, and activation of skeletal muscle mTOR signaling. Muscle-specific Prkaa1 knockout mice on normal and high-fat diet, gene expression analysis, lipid quantification, mTOR signaling assays Journal of physiology and biochemistry Medium 29288408
2023 PRKAA1 induces aberrant mitophagy via the PINK1/Parkin pathway in fluoride-exposed neurons; NaF exposure increases PRKAA1 phosphorylation and upregulates PINK1, Parkin, TOMM-20, and Cyt C, promoting mitophagy and neuronal apoptosis. Both AMPK inhibitor (dorsomorphin) and autophagy inhibitor (3-MA) suppress NaF-induced neuronal apoptosis by restoring aberrant mitophagy. Rat NaF exposure model, SH-SY5Y cell model, phosphoproteomics, Western blot, pharmacological inhibition with dorsomorphin and 3-MA Ecotoxicology and environmental safety Medium 36924562
2022 FTO (fat mass and obesity-associated protein) stabilizes PRKAA1 mRNA by reducing m6A modification; FTO demethylation of m6A marks on PRKAA1 3'-UTR decreases YTHDF2-mediated mRNA degradation, increasing PRKAA1 protein levels and promoting gastric cancer cell growth, glycolysis, and redox balance maintenance. RNA immunoprecipitation for m6A, YTHDF2 interaction assay, FTO overexpression/knockdown, PRKAA1 mRNA stability assays, Western blot, extracellular flux analyzer Neoplasma Medium 36305690
2010 siRNA silencing of PRKAA1 in HEK293 cells increases susceptibility to methylmercury toxicity, while AMPK activator AICAR reduces methylmercury toxicity, indicating PRKAA1/AMPK activation is protective against methylmercury-induced cytotoxicity. siRNA knockdown in HEK293 cells, AICAR pharmacological activation, cell viability assay The Journal of toxicological sciences Low 20686348
2017 miR-181a targets PRKAA1 (validated by luciferase assay) in the dorsal hippocampus; after fear conditioning or object location training, miR-181a expression transiently increases while PRKAA1 expression and activity decrease; microinjection of PRKAA1 agonist AICAR or inhibitor compound C reverses the effects of miR-181a manipulation on hippocampus-dependent memory formation, placing PRKAA1 downstream of miR-181a in memory regulation. Luciferase reporter assay, miR-181a agomir/antagomir stereotaxic injection in mouse dorsal hippocampus, AICAR and compound C microinjection, fear conditioning and object location behavioral assays Scientific reports Medium 28814760
2024 Gentiacaulein inhibits glucose transport into astrocytes, increasing AMP:ATP ratio and inducing PRKAA1-mediated autophagy, which enhances amyloid-β clearance and reduces NF-κB nuclear translocation and inflammatory cytokine (TNF-α, IL-6) release; PRKAA1 knockdown reverses these effects, confirming PRKAA1 as the mediating kinase. Pharmacological treatment of primary astrocytes, ATP/AMP measurement, PRKAA1 siRNA knockdown, autophagy flux assays, NF-κB translocation assay, ELISA for cytokines Autophagy reports Medium 40395536
2025 Selective deletion of Prkaa1 (AMPKα1) in tendon progenitors causes transcriptional alterations in cell cycle regulation and ECM organization by one month, leads to significant reductions in tendon mechanical strength and upregulation of senescence markers p21 and p16 by three months, and progresses to ectopic calcification with age; tendon fibroblasts lacking AMPKα1 show altered ECM substrate adhesion, and voluntary exercise partially rescues ECM organization and reduces senescence marker expression. Conditional Prkaa1 knockout in tendon progenitors, RNA sequencing, mechanical testing, senescence marker immunostaining, in vitro ECM adhesion assays, voluntary exercise intervention bioRxivpreprint Medium

Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2018 PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis. Nature communications 122 30405100
2014 Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity. Autophagy 122 25483961
2014 Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude. Physiological genomics 94 25225183
2015 The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy 88 26029847
2014 Gene of the month. AMP kinase (PRKAA1). Journal of clinical pathology 50 24895169
2017 LINC00152/miR-139-5p regulates gastric cancer cell aerobic glycolysis by targeting PRKAA1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 45 29156518
2018 High glucose suppresses the viability and proliferation of HTR‑8/SVneo cells through regulation of the miR‑137/PRKAA1/IL‑6 axis. International journal of molecular medicine 39 29786111
2010 Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells. Reproduction (Cambridge, England) 39 20876741
2006 Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer. Gynecologic oncology 38 16595147
2014 PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation. Autophagy 34 24988326
2013 Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population. Molecular carcinogenesis 31 23861218
2010 Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells. Molecular reproduction and development 31 20422711
2017 miR-181a involves in the hippocampus-dependent memory formation via targeting PRKAA1. Scientific reports 29 28814760
2019 LINC00473/miR-497-5p Regulates Esophageal Squamous Cell Carcinoma Progression Through Targeting PRKAA1. Cancer biotherapy & radiopharmaceuticals 28 31584290
2018 TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer. Journal of gastrointestinal and liver diseases : JGLD 24 30574617
2022 Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1. Apoptosis : an international journal on programmed cell death 23 35435532
2019 PRKAA1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells Through Activating JNK1 and Akt Pathways. Oncology research 23 31558185
2023 Shouhui Tongbian Capsules induce regression of inflammation to improve intestinal barrier in mice with constipation by targeted binding to Prkaa1: With no obvious toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 22 36906969
2022 PRKAA1, stabilized by FTO in an m6A-YTHDF2-dependent manner, promotes cell proliferation and glycolysis of gastric cancer by regulating the redox balance. Neoplasma 22 36305690
2023 PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity. Ecotoxicology and environmental safety 16 36924562
2014 Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans. World journal of gastroenterology 16 25024613
2020 Expression and Impact of Vaspin on In Vitro Oocyte Maturation through MAP3/1 and PRKAA1 Signalling Pathways. International journal of molecular sciences 15 33302416
2021 CircC6orf132 Facilitates Proliferation, Migration, Invasion, and Glycolysis of Gastric Cancer Cells Under Hypoxia by Acting on the miR-873-5p/PRKAA1 Axis. Frontiers in genetics 14 34659329
2021 Endothelial AMPKα1/PRKAA1 exacerbates inflammation in HFD-fed mice. British journal of pharmacology 14 34796475
2017 Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet. Journal of physiology and biochemistry 14 29288408
2019 Involvement of NF-κB signaling pathway in the regulation of PRKAA1-mediated tumorigenesis in gastric cancer. Artificial cells, nanomedicine, and biotechnology 13 31841039
2021 Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders. Frontiers in cell and developmental biology 12 33511118
2010 siRNA-mediated AMPKalpha1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells. The Journal of toxicological sciences 12 20686348
2016 Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans. Cancer medicine 11 27726301
2018 Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis. Medicine 7 29620653
2023 Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer. BMC medical genomics 6 37670284
2022 Circ_0003340 downregulation mitigates esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis. Thoracic cancer 6 35297212
2018 Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer. BMC cancer 6 30253744
2024 Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes. Autophagy reports 4 40395536
2023 Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study. Frontiers in molecular neuroscience 3 36818655
2020 PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case-control study. Journal of clinical laboratory analysis 3 32488984
2016 Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 3 27612659
2025 Adaptive PRKAA1 variant in Andeans is associated with improved ventilation and sleep phenotypes. iScience 2 40703441
2024 miR-181a expressed in the dorsal hippocampus regulates the reinstatement of cocaine CPP by targeting PRKAA1. Behavioural brain research 0 38878971

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