Affinage

CAMKK2

Calcium/calmodulin-dependent protein kinase kinase 2 · UniProt Q96RR4

Length
588 aa
Mass
64.7 kDa
Annotated
2026-04-28
100 papers in source corpus 35 papers cited in narrative 35 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CaMKK2 is a Ca²⁺/calmodulin-dependent serine/threonine kinase that functions as a master integrator of calcium signaling into diverse cellular processes including energy homeostasis, autophagy, cytoskeletal remodeling, cell cycle control, neuronal development, and immune regulation. Upon Ca²⁺/CaM binding, CaMKK2 autophosphorylates at Thr85 to generate sustained autonomous kinase activity (PMID:26395653) and directly phosphorylates its principal substrates AMPKα (Thr172), CaMKI, CaMKIV, and Akt (Thr308), with isoform-selective responsibility for Ca²⁺-stimulated AMPK activation confirmed by inhibitor-resistant mutant studies (PMID:26050738, PMID:28634229, PMID:19605628). CaMKK2 is inactivated by PKA-mediated phosphorylation at Ser495/Ser100/Ser511, which recruits 14-3-3 adaptors to maintain the inhibited state by preventing dephosphorylation, a mechanism resolved by crystal structures (PMID:32913128, PMID:29649512). Through its AMPK-dependent arm, CaMKK2 controls metabolic outputs including hepatic gluconeogenesis, adipogenesis, autophagy via ULK1/ULK2, mitochondrial dynamics via MFF phosphorylation, and mechanosensitive stress fiber assembly via VASP, while through CaMKIV it drives CREB-dependent transcription essential for neuronal migration and excitation-transcription coupling; additionally, CaMKK2 promotes cancer lipogenesis and metastasis through AMPK-independent pathways including a PDE1A–PKG1–VASP axis (PMID:18460329, PMID:23027865, PMID:35915085, PMID:29972773, PMID:37335130, PMID:30242113).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 2008 High

    Establishing CaMKK2 as a physiological AMPK kinase in vivo resolved which upstream kinase couples calcium signaling to energy sensing in the hypothalamus, revealing that CaMKK2 forms a complex with AMPKα/β subunits and controls appetite through NPY/AgRP production.

    Evidence CaMKK2 null mice, STO-609 inhibition, co-immunoprecipitation of CaMKK2–AMPK complex, in vivo feeding assays

    PMID:18460329

    Open questions at the time
    • Structural basis of CaMKK2–AMPK complex assembly not determined
    • Whether CaMKK2 regulation of AMPK in hypothalamus involves the same autonomous-activity mechanism as in vitro
  2. 2009 High

    Defining the CaMKK2→CaMKIV→CREB→BDNF cascade in cerebellar granule cells established that CaMKK2 is essential for neuronal migration during brain development through transcriptional control of BDNF.

    Evidence CaMKK2/CaMKIV null mice, kinase re-expression and exogenous BDNF rescue, CREB phosphorylation assays

    PMID:19605628

    Open questions at the time
    • Identity of upstream Ca²⁺ signal triggering this cascade during migration not resolved
    • Whether CaMKK2 scaffolding (vs catalytic) function contributes to this pathway
  3. 2011 High

    Demonstrating CaMKK2's roles in adipogenesis suppression (via AMPK-mediated Pref-1/Sox9 maintenance) and granulopoiesis regulation extended its function beyond neurons to metabolic and hematopoietic lineage decisions, with kinase activity required in both contexts.

    Evidence CaMKK2 null mice, STO-609, AICAR rescue for adipogenesis; kinase-dead mutant rescue for myeloid differentiation

    PMID:21816924 PMID:21862616

    Open questions at the time
    • Direct phosphorylation substrates mediating myeloid lineage effects not identified
    • PKA-regulated alternative splicing of CaMKK2 shown in neuroblastoma cells but functional relevance in non-neuronal lineages unknown
  4. 2012 High

    Identification of CaMKK2→AMPK→ULK1 as the amino acid starvation-induced autophagy pathway, and CaMKK2→HDAC5 signaling in hepatic gluconeogenesis, established CaMKK2 as a nutrient-sensing signaling hub beyond calcium alone.

    Evidence CaMKK-β inhibition/knockdown with AMPK KO epistasis for autophagy; liver-specific CaMKK2 deletion with primary hepatocyte glucose production assays

    PMID:22240810 PMID:23027865

    Open questions at the time
    • Whether CaMKK2 directly phosphorylates HDAC5 or acts through an intermediate kinase not established
    • Relative contribution of CaMKK2 vs LKB1 to AMPK-dependent autophagy in normal tissues unclear
  5. 2013 High

    Placing CaMKK2→AMPK upstream of Tau S262 phosphorylation in Aβ42-induced synaptotoxicity provided a mechanistic link between calcium dysregulation and Alzheimer's disease-related dendritic spine loss.

    Evidence shRNA, pharmacological inhibition, Tau S262A rescue mutant, transgenic AD mouse model

    PMID:23583109

    Open questions at the time
    • Whether CaMKK2 inhibition is therapeutic in established AD pathology not tested
    • Direct vs indirect role of AMPK in Tau phosphorylation at other sites not resolved
  6. 2015 High

    Characterization of Thr85 autophosphorylation as the switch generating sustained Ca²⁺-independent autonomous activity resolved how transient calcium signals produce prolonged CaMKK2 signaling, and STO-609-resistant mutants definitively assigned AMPK activation to CaMKK2 (not CaMKKα).

    Evidence T85S mutant kinase assays, CaMKK2 null mouse behavior; STO-609-resistant mutant isoform-specific rescue in A549 cells

    PMID:26050738 PMID:26395653

    Open questions at the time
    • Phosphatase responsible for Thr85 dephosphorylation not identified
    • Whether Thr85 autophosphorylation occurs in an intermolecular or intramolecular manner not resolved
  7. 2015 High

    Identifying CaMKK2 as a scaffold assembling CaMKIV with mTOR/S6K components in hepatocellular carcinoma established that CaMKK2 has both catalytic and non-catalytic roles in promoting cancer cell growth.

    Evidence Kinase-dead mutant rescue failure, co-IP of scaffold complex, in vivo carcinogen-induced HCC model

    PMID:25847065

    Open questions at the time
    • Structural basis of CaMKK2 scaffold interaction with mTOR/S6K components not determined
    • Whether scaffold function is separable from kinase function via point mutations not tested
  8. 2016 High

    Demonstration that CaMKK2→AMPK causes G1 arrest in LKB1-null cells defined the cell cycle checkpoint function of this pathway, with implications for tumor suppressor-deficient cancers.

    Evidence Constitutively active CaMKK2 expression, dominant-negative AMPK, AMPKα1/α2 double KO, flow cytometry in LKB1-null cells

    PMID:27141100

    Open questions at the time
    • Whether CaMKK2-AMPK mediates cell cycle arrest in LKB1-proficient contexts not established
    • Direct AMPK substrates mediating cdc2-Tyr15 phosphorylation not identified
  9. 2017 High

    Discovery that α-ketoglutarate enhances CaMKK2–AMPK binding in LKB1-deficient lung cancer, and that CaMKK2 directly phosphorylates Akt at Thr308 independently of PDK1, expanded the activating inputs and substrate repertoire beyond the canonical Ca²⁺/CaM–AMPK axis.

    Evidence Biochemical binding assays with αKG, patient-derived xenografts; in vitro kinase assay with recombinant CaMKK2 and Akt, siRNA epistasis in ovarian cancer cells

    PMID:28634229 PMID:29249655

    Open questions at the time
    • Structural mechanism by which αKG enhances CaMKK2-AMPK interaction unknown
    • Physiological contexts in which CaMKK2-Akt signaling predominates over PDK1-Akt not mapped
  10. 2017 High

    Systematic characterization of rare human CaMKK2 variants near regulatory sites revealed gain-of-function (S137L, P138S), loss-of-function (G87R, R139W), and dominant-negative mechanisms, providing a framework for genotype-function relationships.

    Evidence In vitro kinase assays of purified mutant proteins, cellular ionomycin-stimulated AMPK phosphorylation, dominant-negative co-expression

    PMID:28230171

    Open questions at the time
    • Clinical phenotypes associated with these variants not characterized
    • Whether dominant-negative variants act by substrate sequestration or complex poisoning not distinguished
  11. 2018 High

    Localization of CaMKK2 to focal adhesions and its requirement for mechanosensitive stress fiber maturation via AMPK-VASP phosphorylation established CaMKK2 as a mechanotransduction kinase controlling contractile force generation.

    Evidence Live-cell imaging, traction force microscopy, pathway inhibitor epistasis

    PMID:29972773

    Open questions at the time
    • How CaMKK2 is recruited to focal adhesions molecularly not determined
    • Whether mechanosensitive channel identity varies across cell types
  12. 2018 High

    Crystal structures of 14-3-3 bound to CaMKK2 phosphopeptides defined the molecular basis of 14-3-3-mediated regulation, showing that 14-3-3 does not directly inhibit CaMKK2 catalysis but instead prevents dephosphorylation of inhibitory sites.

    Evidence X-ray crystallography, SAXS, time-resolved fluorescence, enzyme activity measurements

    PMID:29649512

    Open questions at the time
    • Full-length CaMKK2–14-3-3 complex structure not available
    • Identity of phosphatases counteracting PKA-mediated inhibitory phosphorylation not established
  13. 2020 High

    Detailed structural and biochemical dissection of PKA-mediated CaMKK2 inactivation—showing Ser495 impairs CaM binding while Ser100/Ser511 phosphorylation recruits 14-3-3 to maintain the inactive state—completed the mechanistic picture of CaMKK2's inhibitory regulation, with crystal structures of the ternary 14-3-3ζ/phospho-CaMKK2 complex.

    Evidence In vitro kinase assays, site-directed mutagenesis, X-ray crystallography, fusicoccane stabilization of 14-3-3/CaMKK2 complexes

    PMID:32913128 PMID:33146997

    Open questions at the time
    • Whether PKA-CaMKK2 crosstalk is operative in all CaMKK2-expressing tissues not determined
    • Functional consequences of fusicoccane-mediated CaMKK2 inhibition in vivo not tested
  14. 2020 High

    Demonstration that CaMKK2–AMPK maintains epithelial junctional actomyosin bundles extended the mechanosensitive role of CaMKK2 from single-cell focal adhesions to multicellular tissue integrity.

    Evidence CaMKK2/AMPK inhibition, live imaging, traction force and monolayer stress microscopy

    PMID:32209483

    Open questions at the time
    • Direct CaMKK2 substrates at cell-cell junctions not identified beyond AMPK
    • Whether epithelial defects in vivo arise from CaMKK2 loss not tested in animal models
  15. 2021 High

    Identification of the AR→CAMKK2→AMPK→ULK1 autophagy cascade as a driver of castration-resistant prostate cancer, and AMPK-independent lipogenesis promotion through CaMKK2, dissected parallel oncogenic outputs of CaMKK2.

    Evidence Genetic mouse models, patient tumor samples, CAMKK2 disruption, AMPK-ULK1 phosphorylation assays (autophagy); Camkk2/AMPKβ1 KO epistasis in Pten-deficient prostate cancer (lipogenesis)

    PMID:30242113 PMID:33531625

    Open questions at the time
    • AMPK-independent mechanism by which CaMKK2 controls lipogenic enzyme expression remains unknown
    • Whether combined CaMKK2+androgen receptor targeting is superior to either alone in CRPC not tested
  16. 2022 High

    Discovery that Aβ42-induced CaMKK2–AMPK overactivation coordinates MFF phosphorylation (mitochondrial fission) and ULK2 (mitophagy) to destroy dendritic mitochondria refined the Alzheimer's mechanism from Tau phosphorylation to direct mitochondrial remodeling.

    Evidence Transgenic AD mice, human APPSwe knockin neurons, phosphoproteomics, genetic knockouts

    PMID:35915085

    Open questions at the time
    • Whether MFF and ULK2 are direct AMPK substrates or phosphorylated by intermediate kinases in this context not fully resolved
    • Therapeutic window for CaMKK2 inhibition in neurodegeneration not defined
  17. 2022 High

    Identification of a Cav1.2/CaMKK2/CaMK1a caveolar signaling complex in vascular myocytes established excitation-transcription coupling: local Ca²⁺ influx through Cav1.2 activates CaMKK2→CaMK1a→CREB to drive inflammatory gene expression and vascular remodeling.

    Evidence Super-resolution imaging, proximity ligation assay, co-IP, live Ca²⁺ imaging, caveolin1-KO mice, STO-609

    PMID:35412911

    Open questions at the time
    • Whether this caveolar complex exists in other excitable cell types not determined
    • Direct CaMKK2 phosphorylation site on CaMK1a not mapped in this context
  18. 2023 High

    Discovery of the CaMKK2→PDE1A→PKG1→VASP metastasis pathway demonstrated an AMPK-independent mechanism through which CaMKK2 promotes cancer cell migration by suppressing VASP phosphorylation to enhance F-actin assembly.

    Evidence CRISPR/siRNA, small molecule inhibitors, xenograft metastasis models in TNBC and HGSOC

    PMID:37335130

    Open questions at the time
    • How CaMKK2 regulates PDE1A expression mechanistically not defined
    • Whether this pathway operates in non-cancer cell migration not tested
  19. 2023 High

    Definitive evidence that CaMKK2 is dispensable for contraction-stimulated AMPK activation in adult skeletal muscle—where it is essentially absent—corrected prior assumptions and defined tissue boundaries of CaMKK2 function.

    Evidence CaMKK2 KO mice, selective inhibitor SGC-CAMKK2-1, ex vivo contraction, mass spectrometry proteomics

    PMID:37380024

    Open questions at the time
    • Identity of the kinase responsible for contraction-stimulated AMPK activation in skeletal muscle remains open
    • Whether CaMKK2 is expressed during muscle development but downregulated in adult tissue not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • The full-length structure of CaMKK2 in complex with CaM, AMPK, or 14-3-3 has not been determined, and the AMPK-independent mechanisms by which CaMKK2 controls lipogenesis and PDE1A expression remain molecularly undefined.
  • No full-length CaMKK2 structure in active or autoinhibited conformation
  • Mechanism of AMPK-independent lipogenesis regulation unknown
  • Whether CaMKK2 has additional direct substrates beyond AMPK, CaMKI, CaMKIV, and Akt not systematically addressed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 7 GO:0060090 molecular adaptor activity 2
Localization
GO:0005829 cytosol 2 GO:0005886 plasma membrane 2 GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 8 R-HSA-1643685 Disease 5 R-HSA-1430728 Metabolism 4 R-HSA-1266738 Developmental Biology 2 R-HSA-1640170 Cell Cycle 2 R-HSA-9612973 Autophagy 2 R-HSA-168256 Immune System 1 R-HSA-5357801 Programmed Cell Death 1
Partners
AKT1CAMK1CAMK4GEMIN4PRKAA1PRKAA2YWHAGYWHAZ
Complex memberships
CaMKK2-AMPKα-AMPKβ complexCav1.2/CaMKK2/CaMK1a caveolar complexCdo1-CaMKK2-AMPK ternary complex

Evidence

Reading pass · 35 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 CaMKK2 phosphorylates and activates AMPKα in hypothalamic neurons in response to ghrelin/Ca2+ signals, and forms a unique signaling complex with AMPKα and AMPKβ subunits, thereby regulating hypothalamic NPY/AgRP production and appetite. CaMKK2 null mice, pharmacological inhibition (STO-609), co-immunoprecipitation of CaMKK2/AMPK complex, in vivo feeding studies Cell metabolism High 18460329
2013 Increased intracellular Ca2+ (via NMDA receptor activation or depolarization) activates AMPK in a CAMKK2-dependent manner; AMPK then phosphorylates Tau at S262 (KxGS motif), mediating the synaptotoxic effects of Aβ42 oligomers and dendritic spine loss. shRNA knockdown, overexpression, pharmacological inhibition, Tau S262A rescue mutant, in vivo transgenic AD mouse model Neuron High 23583109
2017 GDH1-produced α-ketoglutarate activates CaMKK2 by enhancing its binding to substrate AMPK, thereby promoting AMPK-dependent energy production and anoikis resistance in LKB1-deficient lung cancer cells. Biochemical binding assays, LKB1-deficient cell lines, genetic and pharmacological inhibition, patient-derived xenograft model Molecular cell High 29249655
2022 Aβ42 oligomer-induced CAMKK2-AMPK overactivation mediates synaptic loss through coordinated phosphorylation of MFF (promoting mitochondrial fission) and ULK2 (promoting mitophagy), causing structural remodeling of dendritic mitochondria. Transgenic AD mouse model, human APPSwe/Swe knockin ES-derived neurons, genetic knockouts, phosphoproteomic analysis Nature communications High 35915085
2015 CaMKK2 signals through CaMKIV and acts as a scaffold to assemble CaMKIV with components of the mTOR/S6K pathway, stimulating protein synthesis and liver cancer cell growth; kinase-dead CaMKK2 cannot rescue growth defects, confirming kinase activity is required. RNAi knockdown, kinase-dead mutant rescue, pharmacological inhibition (STO-609), in vivo carcinogen-induced HCC model, co-immunoprecipitation of scaffold complex Hepatology High 25847065
2017 CaMKK2 directly phosphorylates Akt at Thr-308 in a Ca2+/CaM-dependent manner in ovarian cancer cells, independent of PDK1, providing an alternative mechanism for Akt activation; combined CaMKK2 and PDK1 knockdown showed additive effects on p-Akt reduction. In vitro kinase assay with recombinant CaMKK2 and Akt, siRNA knockdown, intracellular Ca2+ chelation, ionomycin stimulation, pharmacological inhibitors The Journal of biological chemistry High 28634229
2012 Withdrawal of essential amino acids increases cytosolic Ca2+, which activates AMPK via CaMKK-β; activated AMPK then phosphorylates ULK1 at Ser-555 to induce autophagy, and CaMKK-β also contributes to mTORC1 inactivation under these conditions. CaMKK-β inhibition (STO-609), siRNA knockdown, AMPK knockout, Ca2+ chelation, reporter assays The Journal of biological chemistry High 23027865
2020 PKA phosphorylates CaMKK2 at Ser495 (impairing Ca2+/CaM activation), Ser100, and Ser511; phospho-Ser100 and phospho-Ser511 recruit 14-3-3 adaptor proteins that maintain CaMKK2 in an inactivated state by preventing dephosphorylation of phospho-Ser495. Crystal structure of 14-3-3ζ bound to the diphosphorylated CaMKK2 peptide was solved. In vitro kinase assays, site-directed mutagenesis, X-ray crystallography of 14-3-3ζ/CaMKK2 phosphopeptide complex, cell-based phosphorylation studies The Journal of biological chemistry High 32913128
2015 Thr85 is a CaMKK2 autophosphorylation site that generates sustained autonomous (Ca2+-independent) kinase activity following an initial Ca2+ signal; the T85S human variant fails to generate autonomous activity, causing partial loss of function. Lithium (GSK3 inhibitor) can rescue the T85S loss of autonomous activity. Autophosphorylation assay, kinase activity measurements, T85S mutant characterization, CaMKK2 null mice behavioral phenotyping Scientific reports High 26395653
2018 14-3-3γ directly interacts with the kinase domain of CaMKK2 and the region containing inhibitory phosphorylation site Thr145 in the N-terminal extension; this interaction does not inhibit catalytic activity of phosphorylated CaMKK2 but slows its dephosphorylation. Crystal structures of phosphopeptides containing 14-3-3 binding motifs of CaMKK2 bound to 14-3-3 were determined. Enzyme activity measurements, SAXS, time-resolved fluorescence spectroscopy, X-ray crystallography of phosphopeptide-14-3-3 complexes Biochimica et biophysica acta. General subjects High 29649512
2018 CaMKK2 localizes around focal adhesions at the ends of contractile stress fibers; Ca2+ influx through mechanosensitive channels activates CaMKK2, which then activates AMPK to phosphorylate VASP and inhibit actin polymerization at focal adhesions, enabling stress fiber maturation and contractile force generation. Live-cell imaging, AMPK/VASP phosphorylation assays, CaMKK2 inhibition (STO-609), Ca2+ channel inhibition, traction force microscopy Cell reports High 29972773
2009 CaMKK2 and CaMKIV function in a cascade in cerebellar granule cells: CaMKK2/CaMKIV-dependent CREB phosphorylation drives BDNF transcription required for granule cell migration from the external to the internal granule cell layer; loss of either kinase reduces pCREB and BDNF, impairing migration, which is rescued by re-expression of the respective kinase. CaMKK2/CaMKIV null mice, in vivo and in vitro granule cell assays, rescue by re-expression of kinase or exogenous BDNF, CREB phosphorylation measurements The Journal of neuroscience High 19605628
2016 In LKB1-null tumor cells, Ca2+ ionophore-induced activation of endogenous CAMKK2 (or expression of constitutively active CAMKK2) causes G1 cell cycle arrest correlated with AMPK Thr172 phosphorylation; dominant-negative AMPK or double AMPK-α knockout prevents this arrest, establishing CAMKK2→AMPK as the cell cycle arrest pathway. LKB1-null cell lines, Ca2+ ionophore (A23187), constitutively active CAMKK2 mutant expression, dominant-negative AMPK, AMPK-α1/α2 double knockout, flow cytometry Molecular cancer research High 27141100
2011 CaMKK2 is expressed in preadipocytes where it functions as an AMPKα kinase; acute inhibition or deletion of CaMKK2 enhances preadipocyte differentiation into mature adipocytes, an effect reversed by AICAR-mediated AMPK activation; CaMKK2/AMPK signaling maintains Pref-1 and Sox9 expression to suppress adipogenic transcription factors C/EBPβ and C/EBPδ. CaMKK2 null mice, STO-609 pharmacological inhibition, AICAR rescue, mRNA quantification, in vitro differentiation assays Endocrinology High 21862616
2012 CaMKK2 is expressed in liver where it promotes hepatic glucose production; liver-specific CaMKK2 reduction lowers blood glucose and improves glucose tolerance; CaMKK2 KO hepatocytes show decreased gluconeogenic gene expression (G6Pase, PEPCK, PGC-1α) and diminished phosphorylation of HDAC5, implicating HDAC5 dephosphorylation in PGC-1α promoter suppression. Liver-specific Cre-mediated deletion, CaMKK2 floxed mice on HFD, primary hepatocyte glucose production assay, mRNA analysis, HDAC5 phosphorylation measurement Molecular endocrinology High 22240810
2011 CaMKK2 inhibits granulocytic fate commitment and differentiation in myeloid progenitor cells; CaMKK2 expression decreases during granulopoiesis, and ectopic CaMKK2 in null CMPs rescues aberrant granulocyte differentiation in a kinase activity-dependent manner. Bone marrow transplantation, CaMKK2 null mice, in vitro differentiation assays, ectopic CaMKK2 (wild-type vs kinase-inactive) rescue Journal of leukocyte biology High 21816924
2018 CAMKK2 promotes prostate cancer cell growth and lipogenesis independently of AMPK; CAMKK2 deletion or inhibition reduces acetyl-CoA carboxylase and fatty acid synthase expression via a posttranscriptional mechanism, while AMPK activation opposes this effect, demonstrating opposing roles of CAMKK2 and AMPK in lipogenesis. Camkk2 knockout mice with Pten-deficient prostate cancer model, AMPKβ1 knockout, human prostate cancer cell lines, lipogenesis assays Cancer research High 30242113
2021 AR-driven CAMKK2 activates AMPK, which then activates ULK1 to induce autophagy in prostate cancer cells independent of canonical mTOR activity; this CAMKK2-AMPK-ULK1 cascade promotes castration-resistant prostate cancer progression. Genetic mouse models, patient tumor samples, CAMKK2 disruption (siRNA, inhibitor, KO), AMPK-ULK1 phosphorylation assays, tumor growth and survival in CRPC models Oncogene High 33531625
2020 Assembly and maintenance of peripheral actomyosin bundles at epithelial cell-cell junctions is dependent on the mechanosensitive CaMKK2/AMPK signaling pathway; inhibition of this pathway disrupts tension-maintaining actomyosin bundles, redistributes cellular forces, and impairs monolayer integrity. CaMKK2 inhibition, AMPK inhibition, live imaging, traction force microscopy, monolayer stress microscopy Cell reports High 32209483
2023 CaMKK2 regulates cancer cell motility and metastasis through a CaMKK2-PDE1A-PKG1-VASP signaling axis: CaMKK2 increases PDE1A expression, which hydrolyzes cGMP to suppress PKG1 activity, reducing VASP phosphorylation; hypophosphorylated VASP promotes F-actin assembly and cell migration. Genetic disruption (CRISPR/siRNA), small molecule inhibitors, xenograft metastasis models (TNBC and HGSOC), phosphorylation and protein expression assays Cancer research High 37335130
2023 Cdo1 (cysteine dioxygenase) physically tethers CaMKK2 to AMPK by interacting with both proteins, thereby activating AMPK signaling to promote fatty acid oxidation and mitochondrial biogenesis in hepatocytes; this Cdo1-CaMKK2-AMPK axis mediates exercise-induced protection against NAFLD. Hepatocyte-specific Cdo1 KO and overexpression mice, co-immunoprecipitation of Cdo1/CaMKK2/AMPK complex, metabolic assays, exercise intervention Nature communications High 38110408
2022 In vascular myocytes, a molecular complex of Cav1.2/CaMKK2/CaMK1a localizes to caveolae; Ca2+ influx through Cav1.2 directly activates CaMKK2, which phosphorylates CaMK1a, triggering its nuclear translocation and CREB phosphorylation (excitation-transcription coupling), leading to inflammatory gene expression and vascular remodeling. Live Ca2+ imaging with genetically encoded indicators, super-resolution imaging, co-immunoprecipitation, CaMKK2 inhibitor STO609, caveolin1-knockout mice, proximity ligation assay PNAS High 35412911
2016 CaMKK2 suppresses muscle regeneration by inhibiting myoblast proliferation and differentiation through AMPK-mediated cell cycle arrest (cdc2-Tyr15 phosphorylation) and suppression of PGC-1α transcription; CaMKK2 functions as an AMPK kinase in muscle cells, and AMPK activity is required to mediate CaMKK2 effects. C2C12 overexpression/knockdown, AMPK inhibitor/agonist epistasis, in vivo muscle electroporation, freeze-injury regeneration model International journal of molecular sciences Medium 27783047
2011 PKA regulates alternative splicing of CaMKK2 exon 16 to produce variants with differential properties: the exon 16-containing variant promotes neurite branching while the variant lacking exon 16 promotes elongation; both variants are kinase-active in vitro but differentially phosphorylated by PKA in cells. Splicing reporter assays, in vitro kinase assays, RNA interference, neurite morphology analysis in B35 neuroblastoma cells RNA biology Medium 21957496
2020 CAMKK2-CAMK4 signaling regulates receptor-mediated transferrin trafficking and iron homeostasis; loss of CAMKK2 or CAMK4 alters intracellular Ca2+ homeostasis during transferrin receptor internalization, impairs post-translational modifications of transferrin, and leads to iron dyshomeostasis. CAMK4-/- mice, CRISPR/Cas9 CAMKK2/CAMK4 deleted HEK293 cells, transferrin trafficking assays, Ca2+ imaging, proteomics Cell communication and signaling Medium 32460794
2021 CAMKK2 knockdown leads to Golgi expansion, ER stress, abortive autophagy, and impaired lysosomal acidification in cancer cells; proteomics identified Gemin4 as a direct CAMKK2 interactor that bridges CAMKK2 with COPI coat subunits, and CAMKK2 knockdown reduces δ-COP protein levels, indicating a role in COPI-dependent vesicle trafficking. CAMKK2 siRNA knockdown, proteomics/mass spectrometry for interactor identification, co-immunoprecipitation of Gemin4/COPI complex, organelle imaging Cell death & disease Medium 34725334
2019 CaMKK2 is highly expressed in tumor-associated myeloid cells in breast cancer; its inhibition or deletion in myeloid cells increases intratumoral CD8+ T cells and reduces macrophage-mediated T cell suppression; CaMKK2-/- macrophages secrete more T cell-recruiting chemokines and have reduced T cell suppressive capacity. Camkk2-/- mice, breast cancer syngeneic mouse models, bone marrow transplantation, in vitro macrophage/T cell co-culture assays, CD8+ T cell depletion epistasis Nature communications High 31164648
2017 Genotoxic agent etoposide activates AMPK-α1 (but not α2) primarily within the nucleus via Ca2+/CaMKK2 signaling, independent of ATM and LKB1; nuclear CaMKK2-AMPK-α1 activation promotes G1 arrest and enhances cell survival after genotoxic stress. CaMKK2 requirement tested with STO-609 in LKB1-null cancer cell lines, nuclear Ca2+ measurements, AMPK-α1/α2 isoform-specific KO, cell viability assays Molecular cancer research Medium 29133590
2020 Fusicoccanes stabilize the interaction between 14-3-3γ and phosphorylated CaMKK2 by binding at the 14-3-3/CaMKK2 interface, slowing CaMKK2 dephosphorylation and maintaining its phosphorylation-mediated inhibited state. Crystal structures of two ternary complexes were determined. X-ray crystallography of ternary 14-3-3/CaMKK2 phosphopeptide/fusicoccane complexes, fluorescence polarization binding assays, dephosphorylation kinetics ACS chemical biology High 33146997
2016 Wnt5a-induced Ca2+ signals during neuronal polarization facilitate axon outgrowth through a CaMKK-CaMKIα signaling cascade; pharmacological and genetic inhibition of this pathway abolishes Wnt5a-induced axonal elongation, and CaMKIα rescue in knockdown neurons restores axon outgrowth. Ca2+ imaging in cortical slices, pharmacological CaMKK inhibition, CaMKIα knockdown and rescue, cortical neuron morphometry Molecular brain Medium 26772170
2020 BH4 (tetrahydrobiopterin) directly binds CaMKK2 and activates downstream AMPK/CREB/PGC-1α signaling to rescue mitochondrial function and cardiac dysfunction in diabetic cardiomyopathy; identified by proteomics as a novel endogenous CaMKK2 activator. Proteomics, direct binding assay (BH4-CaMKK2), CaMKK2/AMPK/PGC-1α pathway analysis, rodent diabetic cardiomyopathy model Life science alliance Medium 32699151
2015 STO-609-resistant mutants of CaMKKβ (Ala328Thr/Val269Phe) demonstrated that CaMKKβ (CAMKK2), but not CaMKKα, is responsible for ionomycin-induced AMPK Thr172 phosphorylation in cells; both CaMKK isoforms can phosphorylate CaMKIV in living cells. STO-609-resistant mutant cell lines (A549), Ca2+ ionophore stimulation, isoform-specific rescue, AMPK and CaMKIV phosphorylation assays Biochemistry High 26050738
2023 CaMKK2 is not required for contraction-stimulated AMPK activation or glucose uptake in adult mouse skeletal muscle; CaMKK2 protein was undetectable in adult skeletal muscle by mass spectrometry and immunoblot, and CaMKK2 genetic KO or selective inhibition (SGC-CAMKK2-1) did not affect contraction-stimulated AMPK phosphorylation or glucose uptake. CaMKK2 KO mice, selective CaMKK2 inhibitor (SGC-CAMKK2-1), ex vivo contraction, AMPK activity assays, mass spectrometry proteomics, qPCR Molecular metabolism High 37380024
2017 Impact of rare human variant mutations near regulatory phosphorylation sites of CaMKK2 identified functionally: G87R, R139W, R142W, E268K reduce Ca2+-independent autonomous activity; S137L and P138S increase autonomous and Ca2+/CaM-stimulated activities; A329T renders CaMKK2 insensitive to Ca2+/CaM; G87R and R139W act as dominant-negative inhibitors blocking AMPK phosphorylation in cells in response to ionomycin. In vitro kinase assays of purified mutant CaMKK2 proteins, cellular ionomycin stimulation + AMPK phosphorylation as readout, dominant-negative assays Scientific reports High 28230171
2020 X-ray crystallography of CaMKK2-inhibitor complexes revealed that Lys194 and Glu236 are key hinge-binding residues forming hydrogen bonds with inhibitor carboxylate groups, while hydrophobic residues Ile171, Phe267, and Leu319 contribute through CH-π interactions; FMO/PIEDA calculations quantified binding energy contributions. X-ray crystallography (5 CaMKK2-inhibitor structures), FMO calculations, MM-PBSA binding energy prediction, CaMKK2 kinase inhibition assay Journal of molecular graphics and modelling High 32348940

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell metabolism 311 18460329
2013 The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation. Neuron 297 23583109
2017 The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Molecular cell 264 29249655
2016 The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft. Trends in endocrinology and metabolism: TEM 179 27449752
2007 Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction. American journal of physiology. Endocrinology and metabolism 176 17213473
2012 Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β). The Journal of biological chemistry 103 23027865
2015 The camKK2/camKIV relay is an essential regulator of hepatic cancer. Hepatology (Baltimore, Md.) 97 25847065
2017 Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells. The Journal of biological chemistry 94 28634229
2022 Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Nature communications 87 35915085
2019 CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nature communications 84 31164648
2009 CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. American journal of physiology. Regulatory, integrative and comparative physiology 84 19812359
2009 BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. The Journal of neuroscience : the official journal of the Society for Neuroscience 82 19605628
2016 Hypoxia upregulates Malat1 expression through a CaMKK/AMPK/HIF-1α axis. International journal of oncology 76 27499160
2018 Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats. Brain, behavior, and immunity 75 29499303
2011 The Ca2+/calmodulin-dependent protein kinase kinase, CaMKK2, inhibits preadipocyte differentiation. Endocrinology 74 21862616
2007 Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. Journal of affective disorders 70 17197037
2021 NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer. Cancer letters 69 34229059
2016 AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2. Molecular cancer research : MCR 67 27141100
2011 Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes. Journal of cellular biochemistry 67 21312243
2021 CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway. The Journal of investigative dermatology 64 34242660
2016 Store-operated calcium entry-activated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure. Autophagy 61 27791458
2009 Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor. Genes to cells : devoted to molecular & cellular mechanisms 61 19371376
2015 Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt. Clinical cancer research : an official journal of the American Association for Cancer Research 58 26071486
2012 Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. Molecular endocrinology (Baltimore, Md.) 57 22240810
2018 CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis. Cancer research 56 30242113
2019 Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy. Cell death & disease 54 30718467
2018 GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocrine-related cancer 54 29431615
2008 Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway. Regulatory peptides 54 18555543
2023 Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice. Nature communications 53 38110408
2017 Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival. Molecular cancer research : MCR 52 29133590
2016 uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca(2+)/CaMKK/AMPK Axis. International journal of biological sciences 51 26722218
2020 A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway. Journal of cell communication and signaling 50 33136287
2019 Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway. Cell death & disease 50 31511499
2021 Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. Oncogene 47 33531625
2021 Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK-AMPK-Sirt1-Associated Signaling Pathway in Mouse Models. Antioxidants (Basel, Switzerland) 46 34679755
2017 Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Scientific reports 44 28924233
2013 Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. Molecular psychiatry 44 23958956
2008 Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK. Atherosclerosis 44 18191860
2012 Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2-AMPK pathway in 3T3-L1 preadipocytes. Journal of agricultural and food chemistry 43 22273148
2010 The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism. Cellular signalling 42 20206685
2019 Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions. Journal of molecular medicine (Berlin, Germany) 38 31402399
2018 Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Molecular nutrition & food research 37 29683271
2020 CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins. The Journal of biological chemistry 34 32913128
2024 Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer. Journal of advanced research 33 38724006
2018 Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke. The European journal of neuroscience 33 30422362
2018 Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 32 29314250
2018 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochimica et biophysica acta. General subjects 32 29649512
2018 CaMKK2 Regulates Mechanosensitive Assembly of Contractile Actin Stress Fibers. Cell reports 32 29972773
2011 Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. RNA biology 31 21957496
2023 Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 30 37392658
2020 In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds. Molecules (Basel, Switzerland) 30 31941153
2022 A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling. Proceedings of the National Academy of Sciences of the United States of America 29 35412911
2016 Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKKβ/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus. Current molecular medicine 29 27658467
2015 Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. Scientific reports 29 26395653
2022 Regulation and role of CAMKK2 in prostate cancer. Nature reviews. Urology 28 35474107
2022 Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma. Nature communications 28 36309495
2021 Dihydromyricetin Ameliorates Inflammation-Induced Insulin Resistance via Phospholipase C-CaMKK-AMPK Signal Pathway. Oxidative medicine and cellular longevity 28 34650665
2009 Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic beta-cell line. Diabetes, obesity & metabolism 28 19486109
2022 Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway. Antioxidants (Basel, Switzerland) 27 35624663
2023 Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway. Chinese journal of natural medicines 26 37245875
2021 Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway. Scientific reports 26 34330980
2016 Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization. Molecular brain 26 26772170
2016 Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. Molecular endocrinology (Baltimore, Md.) 26 27003444
2014 The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats. Toxicology 26 25089838
2014 Genetic deletion of calcium/calmodulin-dependent protein kinase kinase β (CaMKK β) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice. BMC neuroscience 26 25331941
2023 Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt/β-catenin signal pathway. Journal of translational medicine 25 38082327
2021 Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer. Journal of proteome research 25 33844560
2020 The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy. Frontiers in physiology 25 32625104
2021 Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx. Journal of agricultural and food chemistry 24 34260232
2025 Orchestrating Intracellular Calcium Signaling Cascades by Phosphosite-Centric Regulatory Network: A Comprehensive Analysis on Kinases CAMKK1 and CAMKK2. Omics : a journal of integrative biology 23 40079160
2021 Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. Journal of medicinal chemistry 23 34264658
2021 Dihydromyricetin resists inflammation-induced muscle atrophy via ryanodine receptor-CaMKK-AMPK signal pathway. Journal of cellular and molecular medicine 23 34676967
2018 Androgen Receptor-CaMKK2 Axis in Prostate Cancer and Bone Microenvironment. Frontiers in endocrinology 23 29967592
2016 CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation. International journal of molecular sciences 23 27783047
2011 A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. Journal of leukocyte biology 23 21816924
2017 Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects. Nutrition research (New York, N.Y.) 22 29540272
2020 Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway. Cell reports 21 32209483
2019 CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic Potential. Current osteoporosis reports 21 31115859
2009 Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway. Journal of cellular and molecular medicine 21 19874424
2020 CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis. Cell communication and signaling : CCS 20 32460794
2013 CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem. Trends in molecular medicine 20 23332598
2016 Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients. Journal of neurovirology 19 26785644
2015 Inhibition of CaMKK2 reverses age-associated decline in bone mass. Bone 19 25724145
2024 CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing. Essays in biochemistry 18 39268917
2020 Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method. Journal of molecular graphics & modelling 18 32348940
2020 Hypomorphic CAMKK2 in EA.hy926 endothelial cells causes abnormal transferrin trafficking, iron homeostasis and glucose metabolism. Biochimica et biophysica acta. Molecular cell research 18 32485269
2023 Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis. Cancer research 17 37335130
2018 An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorganic & medicinal chemistry letters 17 29653895
2023 CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 16 37338678
2021 Oxidative stress induced by hydrogen peroxide promotes glycolysis by activating CaMKK/LKB1/AMPK pathway in broiler breast muscle. Poultry science 16 35063808
2020 Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. ACS chemical biology 16 33146997
2019 Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors. Scientific reports 16 31712618
2017 Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation. Scientific reports 16 28230171
2015 Analysis of Distinct Roles of CaMKK Isoforms Using STO-609-Resistant Mutants in Living Cells. Biochemistry 16 26050738
2013 Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes. The Journal of nutritional biochemistry 16 23313043
2023 CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle. Molecular metabolism 15 37380024
2021 CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation. Cell death & disease 15 34725334
2020 BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes. Life science alliance 15 32699151
2019 Hispidulin Enhances TRAIL-Mediated Apoptosis via CaMKK/AMPK/USP51 Axis-Mediated Bim Stabilization. Cancers 15 31817696
2016 Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex. Human brain mapping 15 27004598