Affinage

PRKAB1

5'-AMP-activated protein kinase subunit beta-1 · UniProt Q9Y478

Round 2 corrected
Length
270 aa
Mass
30.4 kDa
Annotated
2026-04-28
91 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PRKAB1 encodes the β1 regulatory subunit of the AMP-activated protein kinase (AMPK) heterotrimer, serving as an obligate scaffold for α–γ subunit assembly and as a direct binding site for allosteric activators at the ADaM site (Val81, Arg83, Ser108) (PMID:8557660, PMID:39936600). Its expression is post-transcriptionally regulated by miR-802, which binds the PRKAB1 3′ UTR to suppress protein levels and hepatic AMPK signaling, thereby modulating lipid metabolism (PMID:33391522, PMID:39309511). PRKAB1-containing AMPK complexes are required for macrophage-mediated hematoma resolution via the AMPK/ATF1/HO-1 axis, for late-stage cardiomyocyte differentiation from human iPSCs, and for autophagy induction downstream of NQO2 inhibition and mTORC1 suppression (PMID:32611235, PMID:33454005, PMID:39936600). Pharmacological activation of PRKAB1 restores intestinal differentiation programs and eliminates colorectal cancer stem cells, positioning this subunit as a druggable node linking metabolic stress sensing to lineage specification (PMID:41118768).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1996 High

    Establishing that AMPK functions as an obligate αβγ heterotrimer resolved the subunit composition question and positioned the β subunit (PRKAB1/β1) as an essential structural component of the kinase complex.

    Evidence Biochemical purification and isoform-specific immunoprecipitation from rat liver

    PMID:8557660

    Open questions at the time
    • No structural detail on β1 interaction interfaces
    • No isoform-specific functional distinctions between β1 and β2 established
  2. 2000 High

    Demonstrating that the β subunit is required for stable heterotrimeric assembly and that AMP-dependence varies with γ isoform identity established PRKAB1 as a scaffolding subunit rather than merely a passenger.

    Evidence Isoform-specific immunoprecipitation and in vitro kinase reconstitution with photolabelling

    PMID:10698692

    Open questions at the time
    • Specific residues mediating β1-α and β1-γ interactions not mapped
    • Whether β1 vs β2 confer distinct AMP sensitivity profiles not resolved
  3. 2017 High

    Identification of MβCD as a direct PRKAB1/β1 ligand that activates AMPK and restores autophagy in Niemann-Pick C1-deficient cells established the β subunit as a druggable allosteric site and linked PRKAB1 to autophagy regulation.

    Evidence siRNA knockdown of PRKAB1/PRKAB2, direct binding assay, autophagic flux and cholesterol storage quantification in NPC1-deficient cells

    PMID:28613987

    Open questions at the time
    • Binding site on β1 not mapped at residue resolution
    • Relative contribution of β1 vs β2 in different tissues unclear
  4. 2020 High

    Genetic knockout studies revealed non-redundant physiological roles for PRKAB1: Prkab1−/− mice fail to resolve hematomas due to impaired macrophage AMPK/ATF1/HO-1 signaling, while PRKAB1-KO iPSCs show defective late-stage cardiomyocyte differentiation distinct from the mesoderm specification failure seen with PRKAB2 loss.

    Evidence Prkab1 knockout mouse hematoma model with BMDM mechanistic dissection; CRISPR/Cas9 isoform-specific knockouts in hiPSCs with RNA-Seq and cardiac marker analysis

    PMID:32611235 PMID:33454005

    Open questions at the time
    • Downstream transcriptional targets of β1-containing AMPK in macrophages beyond HO-1 not catalogued
    • Whether β1-specific post-translational modifications dictate isoform-specific roles is unknown
  5. 2021 High

    Identification of miR-802 as a direct post-transcriptional repressor of PRKAB1 via 3′ UTR binding established a regulatory axis controlling hepatic AMPK activity and lipid metabolism, with the parasite-derived factor Sjp40 acting upstream to relieve this repression.

    Evidence Dual-luciferase 3′ UTR reporter assay, lentiviral miR-802 gain/loss-of-function, Sjp40–CD36 pull-down

    PMID:33391522

    Open questions at the time
    • Whether miR-802 regulation of PRKAB1 operates in non-hepatic tissues not tested
    • Quantitative stoichiometry of miR-802 suppression on AMPK activity not determined
  6. 2024 High

    Replication of miR-802–PRKAB1 targeting in a NAFLD model with liver-specific AAV-miR-802 overexpression solidified PRKAB1 as the rate-limiting target linking miR-802 to hepatic lipid accumulation and pharmacological liver protection.

    Evidence AAV-mediated liver-specific miR-802 overexpression in NAFLD mice, dual-luciferase confirmation, western blotting for PRKAB1 and phospho-AMPK

    PMID:39309511

    Open questions at the time
    • Whether other miR-802 targets contribute to the phenotype not excluded
    • Therapeutic potential of anti-miR-802 for NAFLD not tested in primates
  7. 2025 High

    Residue-level mapping of the buddleoside binding site (Val81, Arg83, Ser108) on PRKAB1 and demonstration that PRKAB1 activation drives mTORC1 inhibition via RPTOR phosphorylation and TFEB-dependent autophagy-lysosomal activation provided a complete molecular pathway from ligand binding to NASH amelioration.

    Evidence CETSA, DARTS, molecular docking, in vivo HFHC-diet NASH model with hepatocyte-specific Tfeb KO

    PMID:39936600

    Open questions at the time
    • Crystal structure of buddleoside–β1 complex not solved
    • Whether Ser108 phosphorylation status modulates buddleoside binding affinity not addressed
  8. 2025 Medium

    Pharmacological PRKAB1 agonism eliminated CDX2-low colorectal cancer stem cells by restoring intestinal differentiation programs and dismantling Wnt/YAP-driven stemness, positioning PRKAB1 as a differentiation therapy target.

    Evidence PRKAB1 agonist in CRC cell lines, xenografts, and patient-derived organoids with transcriptomic profiling

    PMID:41118768

    Open questions at the time
    • Agonist selectivity for β1 over β2 not fully resolved
    • Whether PRKAB1-driven differentiation is AMPK kinase-dependent or involves scaffolding-independent functions not tested
    • In vivo clinical efficacy not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • A high-resolution structure of PRKAB1-containing AMPK bound to ADaM-site ligands, the full spectrum of β1-specific post-translational modifications governing isoform-selective signaling, and the mechanism by which β1 activation preferentially engages differentiation versus metabolic outputs remain unresolved.
  • No co-crystal structure of β1-specific allosteric activators
  • β1 vs β2 tissue-specific signaling logic not systematically dissected
  • Upstream kinase/phosphatase regulation of Ser108 in physiological contexts incompletely characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0060090 molecular adaptor activity 2
Localization
GO:0005829 cytosol 3
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-9612973 Autophagy 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1430728 Metabolism 2
Partners
ATF1PRKAA1PRKAA2PRKAB2PRKAG1PRKAG2RPTOR
Complex memberships
AMPK heterotrimer (α/β1/γ)

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 AMPK was shown to be a heterotrimer composed of catalytic α subunits (α1, α2) and non-catalytic β and γ regulatory subunits; the β subunit (encoded by PRKAB1 in its β1 form) co-purifies with both α isoforms, and both α isoforms are stimulated by AMP and contain non-catalytic β and γ subunits, establishing the obligate heterotrimeric architecture of AMPK. Biochemical purification, immunoprecipitation, isoform-specific antibody characterization, tissue distribution analysis The Journal of biological chemistry High 8557660
2000 The β subunit of AMPK (including the β1 isoform encoded by PRKAB1) was shown to be required for the functional heterotrimeric complex; AMP-dependence of the kinase complex is markedly affected by the identity of the γ isoform, with the β subunit participating in stable assembly of the complex. Isoform-specific antibody immunoprecipitation, kinase activity assays, 8-azido-AMP photolabelling The Biochemical journal High 10698692
2017 Methyl-β-cyclodextrin (MβCD) was shown to directly bind the β-subunits of AMPK (PRKAB1/β1 and PRKAB2/β2), activating AMPK and restoring impaired autophagy flux in Niemann-Pick C1-deficient cells; knockdown of PRKAB1 or PRKAB2 abolished MβCD-mediated reduction of cholesterol storage, demonstrating that PRKAB1 is the molecular target mediating the drug's effect. siRNA knockdown of PRKAB1/PRKAB2, AMPK inhibitor pharmacology, autophagic flux assays, cholesterol storage quantification, direct binding assay Autophagy High 28613987
2020 PRKAB1 (AMPKβ1) is required for normal hematoma resolution in vivo; Prkab1−/− mice showed persistent femoral hematomas at day 9 (vs. complete resolution in littermate controls), accompanied by increased macrophage infiltration, inflammatory activation, and oxidative stress. In bone marrow–derived macrophages, heme-induced expression of HO-1 and lipid regulatory genes (via AMPK/ATF1 pathway) was lost in Prkab1−/− cells. Prkab1 knockout mouse model, perifemoral hematoma model, bone marrow-derived macrophage assays, gene expression analysis Circulation research High 32611235
2020 Loss of PRKAB1 (AMPKβ1) in human induced pluripotent stem cells impairs differentiation into cardiomyocytes at late stages of cardiac maturation, while loss of PRKAB2 (AMPKβ2) abrogates mesoderm specification entirely, demonstrating isoform-specific and non-redundant roles of β1 vs. β2 in cardiac lineage commitment. CRISPR/Cas9 knockout of PRKAB1 or PRKAB2 in hiPSCs, RNA-Seq, cardiac lineage marker expression (cTnT, GATA4, NKX2.5), histochemical staining The Journal of biological chemistry High 33454005
2021 PRKAB1 silencing by siRNA reduces flavone (apigenin/luteolin)-induced autophagic flux in HepG2 liver cells, placing PRKAB1-containing AMPK downstream of NQO2 inhibition in a flavone→NQO2 inhibition→AMPK (PRKAB1)→autophagy signaling axis. siRNA knockdown of PRKAB1, autophagic flux assays (LC3-II), AMPK phosphorylation immunoblotting, NQO2 activity assays Antioxidants (Basel, Switzerland) Medium 34068281
2021 miR-802 suppresses hepatic AMPK signaling by directly binding the 3' untranslated region of mouse Prkab1, thereby decreasing PRKAB1 protein levels and reducing AMPK phosphorylation; schistosome-derived Sjp40 interacts with CD36 on hepatocytes to inhibit miR-802, increasing Prkab1 expression and activating AMPK to reduce lipogenesis. Dual-luciferase reporter assay (miR-802 targeting Prkab1 3'UTR), lentiviral miR-802 inhibitor/overexpression, pull-down (Sjp40-CD36), western blotting, miRNA microarray, quantitative RT-PCR Theranostics High 33391522
2023 PRKAB1 knockout in the castration-resistant prostate cancer cell line C4 was validated by CRISPR/Cas9 to modulate sensitivity to cabazitaxel, identifying PRKAB1 as a determinant of drug response in mCRPC. Genome-wide CRISPR/Cas9 knockout screen, single-gene C4 knockout validation, cell viability assays with cabazitaxel Scientific reports Medium 37270558
2024 miR-802 inhibits hepatic AMPK expression by binding the 3' UTR of mouse Prkab1 (confirmed by dual-luciferase assay); liver-specific overexpression of miR-802 in NAFLD mice impaired schisanhenol (SAL)-mediated liver protection and decreased PRKAB1 protein and phospho-AMPK levels, placing PRKAB1 as a direct miR-802 target in hepatic lipid metabolism. Dual-luciferase reporter assay, liver-specific miR-802 overexpression via AAV, western blotting, miRNA-seq, bioinformatics Acta pharmaceutica Sinica. B High 39309511
2025 Buddleoside directly binds the PRKAB1 subunit of AMPK at residues Val81, Arg83, and Ser108 (the ADaM site), activating AMPK, which then phosphorylates RPTOR to inhibit mTORC1, leading to TFEB-mediated autophagy-lysosomal pathway activation and amelioration of NASH; hepatic Tfeb knockout abrogated these protective effects. CETSA (cellular thermal shift assay), DARTS (drug affinity responsive target stability assay), molecular docking, AMPK kinase assay, mTORC1/TFEB pathway western blotting, hepatocyte-specific Tfeb KO mice, HFHC diet NASH model Autophagy High 39936600
2025 A clinical-grade PRKAB1 agonist reactivated intestinal lineage programs (CDX2 restoration), dismantled Wnt/YAP-driven stemness, and selectively eliminated CDX2-low cancer stem cells across colorectal cancer cell lines, xenografts, and patient-derived organoids, identifying PRKAB1 as a stress polarity sensor whose activation drives differentiation therapy. Machine learning-guided target identification, PRKAB1 agonist pharmacological treatment, CRC cell lines, xenograft models, patient-derived organoids, transcriptome profiling, multivariate analysis Cell reports. Medicine Medium 41118768

Source papers

Stage 0 corpus · 91 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 TSC2 mediates cellular energy response to control cell growth and survival. Cell 3187 14651849
2008 AMPK phosphorylation of raptor mediates a metabolic checkpoint. Molecular cell 3139 18439900
2011 The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature cell biology 2435 21892142
2005 AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell metabolism 2232 16054041
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2004 The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proceedings of the National Academy of Sciences of the United States of America 1500 14985505
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2004 AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 1295 15058305
2010 Network organization of the human autophagy system. Nature 1286 20562859
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2004 The AMP-activated protein kinase cascade--a unifying system for energy control. Trends in biochemical sciences 891 14729328
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2007 Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer research 788 18006825
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2010 AMPK and SIRT1: a long-standing partnership? American journal of physiology. Endocrinology and metabolism 740 20103737
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2007 The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. The Journal of biological chemistry 698 17711846
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 AMP-activated protein kinase plays a role in the control of food intake. The Journal of biological chemistry 606 14742438
1996 Mammalian AMP-activated protein kinase subfamily. The Journal of biological chemistry 575 8557660
2000 Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. The Biochemical journal 489 10698692
2020 SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses. Cell 449 33080218
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2006 Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. The Journal of physiology 425 16873412
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2012 Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes 298 23028138
2017 Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy 72 28613987
2006 Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes. Biology of reproduction 49 17167165
2011 Identification of differentially expressed genes in chickens differing in muscle glycogen content and meat quality. BMC genomics 39 21324179
2003 Study of candidate genes for glycolytic potential of porcine skeletal muscle: identification and analysis of mutations, linkage and physical mapping and association with meat quality traits in pigs. Cytogenetic and genome research 36 14970694
2021 Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism. Theranostics 31 33391522
2010 Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry 31 20821366
2021 Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum. Toxicology 29 34252479
2024 Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism. Acta pharmaceutica Sinica. B 28 39309511
2019 Evidence for liver energy metabolism programming in offspring subjected to intrauterine undernutrition during midgestation. Nutrition & metabolism 28 30923555
2006 Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. Diabetes 27 16505254
2025 Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway. Autophagy 26 39936600
2012 Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain. Journal of psychiatric research 25 22305490
2021 Apigenin and Luteolin Regulate Autophagy by Targeting NRH-Quinone Oxidoreductase 2 in Liver Cells. Antioxidants (Basel, Switzerland) 23 34068281
2022 Network pharmacology and molecular docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus. Computers in biology and medicine 20 36049411
2014 Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS genetics 20 25340873
2021 Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways. Frontiers in oncology 19 33869052
2010 Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC). Breast cancer research and treatment 16 21116708
2003 The bovine 5' AMPK gene family: mapping and single nucleotide polymorphism detection. Mammalian genome : official journal of the International Mammalian Genome Society 16 14724738
2022 Transcriptome Analysis Reveals the Differentially Expressed Genes Associated with Growth in Guangxi Partridge Chickens. Genes 15 35627183
2019 Intake of Red and Processed Meat, Use of Non-Steroid Anti-Inflammatory Drugs, Genetic Variants and Risk of Colorectal Cancer: A Prospective Study of the Danish "Diet, Cancer and Health" Cohort. International journal of molecular sciences 15 30841568
2022 Effect of arginine supplementation on the production of milk fat in dairy cows. Journal of dairy science 13 35965125
2008 Genes and networks expressed in perioperative omental adipose tissue are correlated with weight loss from Roux-en-Y gastric bypass. International journal of obesity (2005) 12 18645576
2023 Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening. Scientific reports 11 37270558
2016 Association of AMPK subunit gene polymorphisms with growth, feed intake, and feed efficiency in meat-type chickens. Poultry science 11 27143764
2021 Muscle Transcriptome Analysis Reveals Molecular Pathways Related to Oxidative Phosphorylation, Antioxidant Defense, Fatness and Growth in Mangalitsa and Moravka Pigs. Animals : an open access journal from MDPI 10 33809803
2020 Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1. Circulation research 10 32611235
2024 New evidence: Metformin unsuitable as routine adjuvant for breast cancer: a drug-target mendelian randomization analysis. BMC cancer 9 38844880
2020 AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification. The Journal of biological chemistry 9 33454005
2011 caCORRECT2: Improving the accuracy and reliability of microarray data in the presence of artifacts. BMC bioinformatics 9 21957981
2022 Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes. Scientific reports 8 36456625
2018 Identification of clinical tumor stages related mRNAs and miRNAs in cervical squamous cell carcinoma. Pathology, research and practice 8 30149901
2024 Drug risks associated with sarcopenia: a real-world and GWAS study. BMC pharmacology & toxicology 5 39511635
2023 Network pharmacology- and molecular docking-based investigation of the therapeutic potential and mechanism of daucosterol against multiple myeloma. Translational cancer research 5 37180669
2022 Carbohydrate intake in recovery from aerobic exercise differentiates skeletal muscle microRNA expression. American journal of physiology. Endocrinology and metabolism 5 36044708
2020 Metformin ameliorates animal models of dermatitis. Inflammopharmacology 5 32347398
2009 Polymorphisms in the promoter region of bovine PRKAB1 gene. Molecular biology reports 5 19609721
2025 Identifying therapeutic target genes for diabetic retinopathy using systematic druggable genome-wide Mendelian randomization. Diabetology & metabolic syndrome 4 40301928
2023 Comparative Efficacy of Metformin and Glimepiride in Modulating Pharmacological Network to Increase BDNF Levels and Benefit Type 2 Diabetes-Related Cognitive Impairment. Biomedicines 4 38001940
2019 Nutrient sensing pathway genes expression dysregulated in patients with T2DM and coronary artery disease. Diabetes research and clinical practice 4 30935928
2009 Single nucleotide polymorphisms and haplotypic diversity in the bovine PRKAB1 gene. Molecular biotechnology 4 19578998
2024 Ruminant Trans Fatty Acid Intake Modulates Inflammation Pathways in the Adipose Tissue Transcriptome of C57BL/6 Mice. Molecular nutrition & food research 3 39396377
2022 Metabolic Adaptations and Substrate Oxidation are Unaffected by Exogenous Testosterone Administration during Energy Deficit in Men. Medicine and science in sports and exercise 3 36563086
2021 SNP discovery of PRKAB1 gene and their associations with growth traits in goats. Animal biotechnology 3 34106801
2024 Genetic association of glycemic traits and antihyperglycemic agent target genes with the risk of lung cancer: A Mendelian randomization study. Diabetes & metabolic syndrome 2 38850595
2022 Comprehensive Analyses of Bone and Cartilage Transcriptomes Evince Ion Transport, Inflammation and Cartilage Development-Related Genes Involved in Chickens' Femoral Head Separation. Animals : an open access journal from MDPI 2 35327184
2026 Jiangtang Decoction for Type 2 Diabetes and NAFLD: Integrative Analysis via Network Pharmacology, Mendelian Randomization, Molecular Docking, and In Vitro Validation. Endocrine, metabolic & immune disorders drug targets 1 40873177
2025 Machine Learning-Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers. bioRxiv : the preprint server for biology 1 37745574
2025 DNA methylation of genes that mediate autophagosome formation contributes to iodine-induced autoimmune thyroiditis: A population-based study conducted at regions with different iodine levels in China. International journal of hygiene and environmental health 1 39965511
2025 Identification of nitric oxide-related key genes in pulmonary hypertension via bioinformatics and in vitro validation for therapeutic target discovery. Computer methods in biomechanics and biomedical engineering 1 40099537
2025 Transcriptomic Dysregulation in Animal Models of Attention-Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms. Brain and behavior 1 40135637
2025 CANDiT: A machine learning framework for differentiation therapy in colorectal cancer. Cell reports. Medicine 1 41118768
2024 Deciphering the Genetic Landscape: Insights Into the Genomic Signatures of Changle Goose. Evolutionary applications 1 39175938
2020 [Partial isoform-specific expression and function of AMPK in ovarian carcinoma]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 1 32727648
2026 PRKAB2 as a tumor suppressor in renal cell carcinoma: inhibiting mitophagy via the LRPPRC-PRKN/parkin interaction and cardiolipin biosynthesis. Autophagy 0 41612594
2026 Evaluating the Impact of Putative Metformin Targets on Cancer Outcomes: A Drug-Target Mendelian Randomization Study. Diabetes, obesity & metabolism 0 41755790
2026 Comparative transcriptomic analysis of AMPK function in lung tissues of yaks and cattle at the same altitude. Comparative biochemistry and physiology. Part D, Genomics & proteomics 0 41967165
2026 Complement activation and fibrinolysis dysregulation drive contrast-induced acute kidney injury: a 4D proteomics rat study. Renal failure 0 41981711
2025 Novel therapeutic targets for metabolism-related diseases: proteomic Mendelian randomization and colocalization analyses. Therapeutic advances in endocrinology and metabolism 0 40453312
2025 Anti-diabetic drug target perturbation modulates susceptibility to aortic aneurysm. European journal of pharmacology 0 41265617
2024 Positive-Unlabelled learning for identifying new candidate Dietary Restriction-related genes among ageing-related genes. Computers in biology and medicine 0 39137672