Affinage

POMP

Proteasome maturation protein · UniProt Q9Y244

Round 2 corrected
Length
141 aa
Mass
15.8 kDa
Annotated
2026-04-28
59 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

POMP is an intrinsically disordered, transiently acting assembly chaperone essential for biogenesis of the 20S proteasome core particle. It associates with alpha-rings at the endoplasmic reticulum, recruits beta-subunits stepwise into half-proteasome precursor complexes, and directly engages the beta7 propeptide via its N-terminal domain to drive half-proteasome dimerization, after which it is degraded upon autocatalytic maturation of the nascent 20S particle (PMID:10926487, PMID:17948026, PMID:35204754). Its expression is induced by interferon-gamma and the transcription factor NRF3, and is post-transcriptionally repressed by miR-101; loss of POMP causes proteasome insufficiency, ER stress, and impaired NF-κB signaling, while dominant-negative truncating variants escaping NMD cause PRAID (POMP-related autoinflammation and immune dysregulation) and a 5′ UTR mutation causes the keratinization disorder KLICK (PMID:20226437, PMID:29805043, PMID:26145175, PMID:32123008). POMP overexpression is sufficient to increase functional proteasome levels and enhance cellular resistance to oxidative stress (PMID:17349762).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2000 High

    Identification of POMP as the human Ump1 orthologue present exclusively in proteasome precursor complexes established that 20S assembly requires a dedicated, transient chaperone induced by interferon-gamma.

    Evidence 2D gel electrophoresis of precursor fractions, Northern blot, and mutant LMP7 incorporation assays in T2 cells

    PMID:10926487

    Open questions at the time
    • Structural basis of POMP–precursor interaction unknown
    • Subcellular site of assembly not determined
    • Mechanism of POMP degradation upon maturation unclear
  2. 2007 High

    Localization of proteasome assembly to the endoplasmic reticulum resolved where POMP orchestrates the stepwise recruitment of beta-subunits onto alpha-rings, and yeast genetics revealed that Ump1 enforces an assembly checkpoint overcome by beta7 addition to drive half-proteasome dimerization.

    Evidence Subcellular fractionation, co-IP, and immunofluorescence in mammalian cells; genetic bypass/suppressor analysis and biochemical fractionation of assembly intermediates in yeast

    PMID:17431397 PMID:17948026

    Open questions at the time
    • Direct POMP–beta7 interaction not demonstrated in vitro
    • Structural intermediates not resolved at high resolution
    • Role of PAC1-4 co-chaperones in relation to POMP not fully delineated
  3. 2007 Medium

    Overexpression of POMP in human fibroblasts proved sufficient to increase functional proteasome levels and enhance resistance to oxidative stress, establishing POMP as a rate-limiting factor in proteasome biogenesis with physiological consequences.

    Evidence Stable overexpression, proteasome activity assays, and oxidative stress survival assays in human fibroblasts

    PMID:17349762

    Open questions at the time
    • Whether endogenous POMP levels are limiting in vivo not addressed
    • No in vivo animal model tested
  4. 2010 High

    Discovery that a 5′ UTR mutation in POMP causes KLICK genodermatosis linked proteasome assembly deficiency to a human Mendelian skin disease and revealed the sensitivity of terminal epidermal differentiation to POMP dosage.

    Evidence SNP analysis, Northern blot, immunohistochemistry, and analysis of patient-derived keratinocytes

    PMID:20226437

    Open questions at the time
    • Precise mechanism by which 5′ UTR shift reduces functional POMP protein not fully resolved
    • No rescue experiment in patient cells reported
  5. 2012 High

    siRNA silencing of POMP in organotypic epidermal cultures demonstrated that loss of proteasome assembly causes ER stress, defective profilaggrin processing, and unfolded protein response activation, providing a mechanistic basis for KLICK pathology.

    Evidence siRNA knockdown in air-liquid interface keratinocyte cultures, immunohistochemistry, Western blot, CHOP induction assay

    PMID:22235297

    Open questions at the time
    • Specific proteasome substrates accumulating in POMP-deficient epidermis not catalogued
    • Contribution of immunoproteasome versus constitutive proteasome not distinguished
  6. 2013 Medium

    Biophysical characterization of yeast Ump1 as an intrinsically disordered protein suggested that POMP-family chaperones acquire structure only upon engagement with proteasome subunits, rationalizing their transient incorporation.

    Evidence Recombinant protein NMR, gel filtration, and bioinformatics

    PMID:24688736

    Open questions at the time
    • No direct evidence that human POMP is similarly disordered
    • Functional consequence of IDP nature not tested by mutagenesis
  7. 2015 High

    Identification of miR-101 as a direct post-transcriptional repressor of POMP revealed that POMP levels are rate-limiting for tumor cell proteasome capacity, and that POMP knockdown is sufficient to overcome bortezomib resistance.

    Evidence miRNA overexpression, POMP knockdown and miR-101-resistant rescue, proteasome activity assays, bortezomib resistance experiments in multiple cell lines

    PMID:26145175

    Open questions at the time
    • In vivo relevance of miR-101–POMP axis in tumors not demonstrated
    • Whether other miRNAs converge on POMP not explored
  8. 2015 Medium

    A patient POMP mutation combined with MCM3AP deficiency showed that POMP-dependent proteasome assembly is required for DNA damage-induced NF-κB signaling, extending POMP's functional reach beyond proteostasis to immune signaling.

    Evidence Whole-exome sequencing, complementation with wild-type POMP in patient-derived cells

    PMID:26615982

    Open questions at the time
    • Digenic context complicates attribution of phenotype to POMP alone
    • Single patient—generalizability uncertain
  9. 2018 High

    Dominant-negative POMP frameshift variants that escape NMD were shown to poison proteasome assembly, causing PRAID—a syndromic autoinflammatory immunodeficiency—demonstrating that truncated POMP actively disrupts the assembly pathway.

    Evidence Whole-exome sequencing, NMD escape assay, proteasome assembly analysis, patient cell characterization

    PMID:29805043

    Open questions at the time
    • Structural basis of dominant-negative interference not determined
    • Whether haploinsufficiency alone is pathogenic not resolved
  10. 2020 High

    NRF3 was identified as a direct transcriptional activator of POMP in cancer cells, showing that the NRF3–POMP axis promotes ubiquitin-independent 20S-mediated degradation of p53 and Rb to drive colorectal tumorigenesis.

    Evidence ChIP, reporter assays, knockdown/overexpression, protein stability assays with proteasome and E1 inhibitors, tumorigenesis assays

    PMID:32123008

    Open questions at the time
    • Whether NRF3–POMP axis operates in non-cancer tissues not addressed
    • Structural selectivity of 20S for disordered tumor suppressors not mechanistically resolved
  11. 2022 High

    In vitro reconstitution demonstrated that the N-terminal 16 residues of Ump1 directly bind the beta7 propeptide, identifying the minimal interaction that triggers half-proteasome dimerization and providing the first direct binding evidence for this critical assembly step.

    Evidence In vitro binding assays, Ump1 and beta7 deletion mutants, yeast genetic rescue, native gel analysis of assembly intermediates

    PMID:35204754

    Open questions at the time
    • No equivalent binding data for human POMP–beta7
    • Atomic-resolution structure of the POMP–beta7 interface lacking

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include the high-resolution structural basis of POMP within mammalian half-proteasome precursors, the mechanism of its concerted degradation upon 20S maturation, in vivo validation of its reported nucleolar stress-sensing role, and whether its cardiac developmental function reflects proteasome-dependent or moonlighting activity.
  • No published atomic-resolution structure of human POMP bound to assembly intermediates (cryo-EM preprint awaits peer review)
  • Mechanism of POMP degradation upon 20S maturation not reconstituted
  • Nucleolar moonlighting role reported only in a preprint

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0044183 protein folding chaperone 5 GO:0098772 molecular function regulator activity 3
Localization
GO:0005634 nucleus 1 GO:0005783 endoplasmic reticulum 1 GO:0005829 cytosol 1
Pathway
R-HSA-392499 Metabolism of proteins 5 R-HSA-1643685 Disease 2 R-HSA-168256 Immune System 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
HSF1NRF3PAC1PAC2PSMA7PSMB5PSMB7
Complex memberships
15S half-proteasome precursor complex20S proteasome precursor (16S intermediate)

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 POMP (hUmp1) was identified as the human homologue of yeast Ump1 and shown to be present exclusively in 20S proteasome precursor complexes (16S intermediates) but not in mature 20S proteasomes, establishing its role as a transient assembly chaperone. POMP expression is induced by interferon-gamma. The beta5 propeptide is not essential for LMP7 incorporation in human cells (unlike yeast), but its deletion leads to delayed proteasome maturation and accumulation of POMP-containing precursor complexes. 2D gel electrophoresis of precursor fractions, Northern blot, mutant LMP7 incorporation assays in T2 cells Journal of molecular biology High 10926487
2007 The main steps of mammalian 20S proteasome core complex formation take place at the endoplasmic reticulum (ER). POMP interacts with ER membranes, binds to alpha1-7 rings, recruits beta-subunits stepwise, and mediates the association of precursor complexes with the ER, coordinating the assembly process. Precursor complex-specific antibodies, subcellular fractionation, immunofluorescence, co-immunoprecipitation EMBO reports High 17948026
2007 In yeast, beta7 (Pre4) overproduction bypasses the requirement for the beta5 propeptide by a mechanism dependent on a unique beta7 C-terminal extension. Assembly proceeds stepwise through precursor dimers containing the Ump1 assembly factor and a Pba1-Pba2 complex. Ump1 enforces an assembly checkpoint; beta7 addition overcomes this checkpoint and stabilizes the precursor dimer to drive dimerization of two half-proteasomes. Genetic bypass/suppressor analysis, identification of assembly intermediates, biochemical fractionation, yeast genetics The EMBO journal High 17431397
2006 POMP protein elutes from a calibrated gel-filtration column at approximately 64 kDa, suggesting tetramer formation. Immunofluorescence and confocal microscopy showed POMP localizes to both cytoplasm and nucleus. Gel filtration chromatography, immunofluorescence, confocal microscopy International journal of biological macromolecules Medium 16624403
2010 A single-nucleotide deletion at position c.-95 in the POMP 5' UTR causes a transcriptional switch, markedly increasing POMP transcript variants with long 5' UTRs in keratinocytes. This is associated with altered epidermal distribution of POMP, proteasome subunits alpha7 and beta5, and ER stress marker CHOP, causing KLICK genodermatosis. These findings demonstrate a critical role for POMP-mediated proteasome assembly in terminal epidermal differentiation. SNP analysis, sequencing, Northern blot, immunohistochemistry, patient-derived keratinocytes American journal of human genetics High 20226437
2012 siRNA silencing of POMP in epidermal air-liquid cultures caused aberrant proteasome subunit staining, perturbed profilaggrin-to-filaggrin processing, and activated the unfolded protein response (CHOP induction/ER stress), establishing that POMP is required for proteasome assembly in differentiating keratinocytes and that its loss leads to proteasome insufficiency and ER stress. siRNA knockdown, organotypic culture, immunohistochemistry, Western blot, CHOP induction assay PloS one High 22235297
2013 Yeast Ump1 is an intrinsically disordered protein (IDP) that lacks stable secondary structure in solution. Recombinant Ump1 forms oligomers mediated by intermolecular disulfide bonds through its single cysteine residue. The disordered nature may allow Ump1 to become structured only upon interaction with proteasome subunits. Recombinant protein expression, gel filtration, NMR, bioinformatics, biochemical analysis Computational and structural biotechnology journal Medium 24688736
2015 miR-101 directly targets POMP, leading to impaired proteasome assembly and activity, accumulation of p53 and CDK inhibitors, cell cycle arrest, and apoptosis. miR-101-resistant POMP restores proteasome substrate turnover and tumor cell growth. POMP knockdown is sufficient to overcome bortezomib resistance in tumor cells, and suppressing POMP attenuates estrogen-driven transcription in ERα-positive breast cancers. miRNA overexpression, POMP knockdown, proteasome activity assays, cell cycle and apoptosis assays, bortezomib resistance rescue experiments Molecular cell High 26145175
2015 POMP mutation combined with MCM3AP (GANP) mutation in an immunodeficient patient results in impaired NF-κB signaling after DNA damage. Complementation with wild-type POMP rescued defective NF-κB signaling, establishing that POMP-dependent proteasome assembly is required for efficient DNA damage-induced NF-κB signaling. Whole-exome sequencing, Sanger sequencing, complementation assay with wild-type POMP, patient-derived cell characterization Human mutation Medium 26615982
2017 POMP binds to 20S proteasome precursor complexes and is overexpressed in lesional psoriatic skin. POMP silencing in HaCaT keratinocytes inhibited cell proliferation and induced apoptosis through inhibition of proteasome assembly, and also decreased expression of differentiation markers keratin 10 and involucrin during calcium-induced differentiation. Native gel electrophoresis, Western blot, IHC, qPCR, siRNA silencing, cell proliferation and apoptosis assays Journal of dermatological science Medium 28728908
2018 Heterozygous frameshift variants in the penultimate exon of POMP escape nonsense-mediated mRNA decay (NMD) and produce a truncated protein that perturbs proteasome assembly by a dominant-negative mechanism, causing PRAID (POMP-related autoinflammation and immune dysregulation disease) with early-onset combined immunodeficiency, inflammatory neutrophilic dermatosis, and autoimmunity. Whole-exome sequencing, NMD assay, proteasome assembly analysis, patient cell characterization, biochemical analysis of truncated protein American journal of human genetics High 29805043
2020 NRF3 transcription factor directly induces POMP gene expression in cancer cells, upregulating 20S proteasome assembly. The NRF3-POMP axis promotes ubiquitin-independent proteolysis of tumor suppressors p53 and Rb by the 20S proteasome, supporting colorectal cancer development and metastasis, and conferring impaired sensitivity to bortezomib (but not to E1 inhibitor TAK-243). NRF3 knockdown, POMP overexpression/knockdown, reporter assays, protein stability assays with proteasome inhibitors, ChIP, cell viability and tumorigenesis assays Molecular and cellular biology High 32123008
2022 An N-terminal domain of yeast Ump1 (first 16 residues) and the propeptide of beta7 promote direct interaction of the two proteins in vitro. This interaction is critical for recruitment of beta7 precursor during proteasome assembly, a step that drives dimerization of 15S half-proteasome precursor complexes and formation of mature 20S core particles. Deletion of the first 16 Ump1 residues causes accumulation of 15S PC intermediates and requires Rpn4-dependent transcription for viability, which is rescued by beta7 overexpression. In vitro binding assay, mutational analysis of Ump1 and beta7, yeast genetics (epistasis, rescue), native gel analysis of intermediates Biomolecules High 35204754
2025 Upon proteasome disruption, POMP rapidly accumulates in the nucleolus in a manner dependent on HSF1 and reactive oxygen species (ROS). Proteomic analysis reveals POMP interacts with RNA processing factors in this context, and transcriptomic profiling shows nucleolar POMP orchestrates a protective transcriptional program, revealing a moonlighting role as a stress-induced transcriptional regulator beyond its canonical chaperone function. This mechanism is developmentally controlled and active in neurodegenerative disease contexts. Live-cell imaging, proteomic interactor analysis, transcriptomic profiling, HSF1/ROS perturbation experiments bioRxivpreprint Medium bio_10.1101_2025.04.25.650603
2024 Cryo-EM structural analysis of human 20S proteasome biogenesis revealed: PAC1-4 stabilize an early alpha-ring intermediate; PAC3/PAC4 dissociation and PAC1 N-terminal tail rearrangement trigger beta-ring assembly; completion of the beta-ring and half-proteasome dimerization repositions lysine K33 to trigger cleavage of beta propeptides, leading to concerted dissociation of POMP and PAC1/PAC2 to yield mature 20S proteasomes. CRISPR/Cas9 endogenous tagging of chaperones, cryo-EM structural analysis of chaperone-bound complexes bioRxivpreprint Medium bio_10.1101_2024.08.08.607236
2007 Overexpression of hUMP1/POMP in human fibroblasts increases levels of functional proteasome and enhances cellular capacity to cope with oxidative stressors, demonstrating that POMP-mediated proteasome assembly upregulation is sufficient to enhance antioxidant defense. Stable overexpression in fibroblasts, proteasome activity assays, oxidative stress survival assays Experimental gerontology Medium 17349762
2025 CRISPR-generated pomp mutant zebrafish embryos display defects in myocardial cell shapes and outflow tract development, establishing a critical role for POMP in heart development. These cardiac phenotypes resemble those of other zebrafish congenital heart defect gene mutants. CRISPR mutagenesis in zebrafish, phenotypic analysis of heart morphology (myocardial cell shape, outflow tract) bioRxivpreprint Medium bio_10.1101_2025.01.16.633339

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 2031 21478870
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2000 DNA cloning using in vitro site-specific recombination. Genome research 815 11076863
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2021 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 532 33845483
2015 Widespread macromolecular interaction perturbations in human genetic disorders. Cell 454 25910212
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
1996 Generation and analysis of 280,000 human expressed sequence tags. Genome research 376 8889549
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2021 Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell metabolism 239 34800366
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2000 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome research 161 11042152
2019 A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature immunology 159 30833792
2001 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome research 151 11230166
2020 A High-Density Human Mitochondrial Proximity Interaction Network. Cell metabolism 148 32877691
2007 beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. The EMBO journal 133 17431397
2018 Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome. American journal of human genetics 126 29805043
2000 Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes. Journal of molecular biology 103 10926487
2022 SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 95 35157496
2007 The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO reports 90 17948026
2016 Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. Cell reports 77 26972000
2005 Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome? Free radical biology & medicine 69 16337885
2022 Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery. Nature communications 65 35831314
2015 MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Molecular cell 63 26145175
2013 Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Molecular & cellular proteomics : MCP 63 23824909
2010 A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis. American journal of human genetics 62 20226437
2021 Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Nature communications 51 34732716
2007 Overexpression of hUMP1/POMP proteasome accessory protein enhances proteasome-mediated antioxidant defence. Experimental gerontology 50 17349762
1997 Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides. FEBS letters 48 9428647
2019 LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science (New York, N.Y.) 47 31073040
2006 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Biochemical and biophysical research communications 45 16712791
2015 Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. PLoS genetics 42 26288249
2001 Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency. Blood 42 11369620
2020 NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein. Molecular and cellular biology 39 32123008
2005 RNA interference toward UMP1 induces proteasome inhibition in Saccharomyces cerevisiae: evidence for protein oxidation and autophagic cell death. Free radical biology & medicine 28 15607905
2013 Biochemical and biophysical characterization of recombinant yeast proteasome maturation factor ump1. Computational and structural biotechnology journal 23 24688736
1975 Acute lymphoblastic leukaemia: cyclical chemotherapy with three combinations of four drugs (COAP-POMP-CART regimen). British medical journal 22 1060502
2015 MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child. Human mutation 20 26615982
2012 siRNA silencing of proteasome maturation protein (POMP) activates the unfolded protein response and constitutes a model for KLICK genodermatosis. PloS one 20 22235297
2006 Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation. International journal of biological macromolecules 18 16624403
2013 Backbone ¹H, ¹³C and ¹⁵N assignments of yeast Ump1, an intrinsically disordered protein that functions as a proteasome assembly chaperone. Biomolecular NMR assignments 16 24065419
2000 Expression of UMP1 is inducible by DNA damage and required for resistance of S. cerevisiae cells to UV light. Current genetics 15 10975253
2017 The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin. Journal of dermatological science 12 28728908
2023 Regulation of symbiotic interactions and primitive lichen differentiation by UMP1 MAP kinase in Umbilicaria muhlenbergii. Nature communications 11 37914724
2000 Proteasome mutants, pre4-2 and ump1-2, suppress the essential function but not the mitochondrial RNase P function of the Saccharomyces cerevisiae gene RPM2. Genetics 10 10757750
2007 The spectrum of spontaneous mutations caused by deficiency in proteasome maturase Ump1 in Saccharomyces cerevisiae. Current genetics 9 17909815
2020 KLICK Syndrome Linked to a POMP Mutation Has Features Suggestive of an Autoinflammatory Keratinization Disease. Frontiers in immunology 8 32425927
2022 Interaction with the Assembly Chaperone Ump1 Promotes Incorporation of the β7 Subunit into Half-Proteasome Precursor Complexes Driving Their Dimerization. Biomolecules 6 35204754
2015 Blocking Cancer Growth with Less POMP or Proteasomes. Molecular cell 6 26186288
2019 Expression analysis of proteasome maturation protein (POMP) gene in Liaoning Cashmere goat. Animal biotechnology 3 30957645
2013 Effect of proton pomp inhibitor (PPI : Rabeprazole) on reflux esophagitis after endoscopic injection sclerotherapy (EIS), a randomized control study (24 hour-pH monitoring). Fukuoka igaku zasshi = Hukuoka acta medica 2 24693675
2021 Phylogenetic and molecular analysis based on genes 16S-rRNA, OMPA and POMP to identify Chlamydia abortus infection occurrence at the milk samples of goats and sheep in west Azerbaijan of Iran. Iranian journal of microbiology 1 34557276
2015 [Effect of H2-receptor antagonist and proton pomp inhibitor on the treatment of acid-related disease]. Nihon rinsho. Japanese journal of clinical medicine 0 26165073