Affinage

PSMG1

Proteasome assembly chaperone 1 · UniProt O95456

Round 2 corrected
Length
288 aa
Mass
32.9 kDa
Annotated
2026-04-28
130 papers in source corpus 3 papers cited in narrative 3 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PSMG1 (PAC1) forms an obligate heterodimer with PSMG2 (PAC2) that functions as a dedicated assembly chaperone for the mammalian 20S proteasome, providing a scaffold for alpha-ring formation, maintaining alpha-ring competence for half-proteasome maturation, and undergoing degradation upon completion of the mature 20S particle (PMID:16251969). Conditional knockout in mice reveals that PAC1 is essential for embryonic development and is responsible for generating the majority of free latent 20S proteasomes in adult cells; loss of PAC1 abolishes the latent 20S pool, causes ubiquitinated protein accumulation, and triggers premature senescence (PMID:20498273). PAC1–PAC2 dimerization and stability are further regulated by iRhom1, which is induced under ER stress and promotes proteasome assembly, particularly in ER-containing compartments (PMID:26109405).

Mechanistic history

Synthesis pass · year-by-year structured walk · 3 steps
  1. 2005 High

    Identification of the PAC1–PAC2 heterodimer as a dedicated 20S proteasome assembly chaperone resolved how mammalian alpha-ring formation is initiated and coordinated, establishing that the chaperone is consumed upon proteasome maturation.

    Evidence Reciprocal co-immunoprecipitation, sucrose-gradient sedimentation, siRNA knockdown, and overexpression in mammalian cells

    PMID:16251969

    Open questions at the time
    • In vivo essentiality of PAC1 was not tested
    • Structural basis of alpha-ring scaffolding by PAC1–PAC2 was not resolved
    • Regulation of PAC1–PAC2 levels or activity by upstream signals was unknown
  2. 2010 High

    Genetic ablation of PAC1 in mice demonstrated that the chaperone is essential for embryonic viability and is the primary source of the free latent 20S proteasome pool in adult cells, linking PAC1 function to ubiquitin homeostasis and cellular senescence.

    Evidence Conditional gene knockout in mice with native PAGE, ubiquitin accumulation assay, proteasome activity assay, and senescence assay in hepatocytes

    PMID:20498273

    Open questions at the time
    • Why 26S proteasome levels are maintained despite loss of the free 20S pool was not mechanistically explained
    • The specific substrates of the latent 20S proteasome pool were not identified
    • Tissue-specific requirements beyond liver were not fully characterized
  3. 2015 Medium

    Discovery that iRhom1 interacts with and stabilizes the PAC1–PAC2 complex under ER stress provided the first upstream regulatory mechanism for proteasome assembly chaperone activity.

    Evidence Co-immunoprecipitation, native PAGE, siRNA knockdown, proteasome activity assay, and subcellular fractionation in mammalian cells with Drosophila genetic rescue

    PMID:26109405

    Open questions at the time
    • Finding from a single study; independent confirmation of the iRhom1–PAC1 interaction is lacking
    • The molecular mechanism by which iRhom1 promotes PAC1–PAC2 dimerization was not resolved
    • Whether other stress pathways regulate PAC1–PAC2 stability remains unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Structural details of how the PAC1–PAC2 heterodimer scaffolds alpha-ring assembly, the identity of substrates uniquely processed by the latent 20S proteasome pool, and additional upstream regulators of PAC1 remain uncharacterized.
  • No high-resolution structure of the PAC1–PAC2 complex bound to proteasome precursors
  • Specific substrates of the PAC1-dependent latent 20S pool are unknown
  • Tissue-specific and developmental regulation of PAC1 beyond hepatocytes is largely unexplored

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0044183 protein folding chaperone 2
Localization
GO:0005783 endoplasmic reticulum 1 GO:0005829 cytosol 1
Pathway
R-HSA-392499 Metabolism of proteins 2
Partners
PSMG2RHBDF1
Complex memberships
20S proteasome precursorPAC1–PAC2 heterodimer

Evidence

Reading pass · 3 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 PSMG1 (PAC1) and PSMG2 (PAC2) form a heterodimer that acts as a dedicated chaperone for mammalian 20S proteasome assembly. The PAC1–PAC2 complex associates with proteasome precursors, provides a scaffold for alpha-ring formation, keeps alpha-rings competent for subsequent half-proteasome formation, and is degraded upon completion of the mature 20S proteasome. Overexpression of PAC1 or PAC2 accelerates precursor formation, while siRNA knockdown impairs 20S proteasome maturation. Co-immunoprecipitation, sucrose-gradient sedimentation, siRNA knockdown, overexpression in mammalian cells, native PAGE Nature High 16251969
2010 Conditional knockout of PAC1 (PSMG1) in mice causes early embryonic lethality, demonstrating that PAC1-dependent 20S proteasome assembly is essential for mammalian development. In adult hepatocytes, PAC1 is responsible for producing the majority of 20S proteasomes; PAC1-deficient hepatocytes retain normal 26S proteasome levels but completely lose the free latent 20S proteasome pool, accumulate ubiquitinated proteins, and undergo premature senescence, establishing an essential role for the latent 20S proteasome in cellular homeostasis. Conditional gene knockout in mice, native PAGE, ubiquitin accumulation assay, cellular senescence assay, proteasome activity assay Molecular and cellular biology High 20498273
2015 iRhom1 physically interacts with the 20S proteasome assembly chaperones PAC1 (PSMG1) and PAC2 (PSMG2), stabilizing their protein levels. Under ER stress, iRhom1 expression is induced and promotes PAC1–PAC2 dimerization; knockdown of iRhom1 impairs PAC1–PAC2 dimerization and reduces proteasome complex assembly and enzymatic activity, particularly in ER-containing microsomes. Co-immunoprecipitation, native PAGE, proteasome activity assay, siRNA knockdown, fractionation, Drosophila genetic rescue Scientific reports Medium 26109405

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2000 The DNA sequence of human chromosome 21. Nature 808 10830953
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2011 Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 623 21350482
2010 Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nature genetics 520 20062062
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2011 Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 426 21300955
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
1994 Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature 325 8107850
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
1993 PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science (New York, N.Y.) 292 7681221
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2008 Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nature genetics 269 18758464
2003 The Sclerotinia sclerotiorum pac1 gene is required for sclerotial development and virulence. Molecular plant-microbe interactions : MPMI 222 12971602
2006 Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nature immunology 217 16474395
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2005 A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature 208 16251969
2009 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science signaling 207 19738201
2003 The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast. The Journal of cell biology 205 12566428
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2009 A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC genomics 193 19379481
2020 Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Molecular cell 159 32416067
2019 A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature immunology 159 30833792
2000 PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. The Journal of clinical investigation 153 10792006
2008 Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PloS one 148 18461144
2014 Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. The EMBO journal 139 24811749
2018 Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Molecular cell 136 30554943
2003 PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature 125 12673251
2003 PAC1, a pH-regulatory gene from Fusarium verticillioides. Applied and environmental microbiology 118 12957906
2015 Neuronal PAC1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine. Science translational medicine 117 26446954
2009 Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. Journal of medicinal chemistry 109 19708658
2008 Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Peptides 100 18353507
2014 PAC1 receptor antagonism in the bed nucleus of the stria terminalis (BNST) attenuates the endocrine and behavioral consequences of chronic stress. Psychoneuroendocrinology 92 25001965
2020 The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity. Nature immunology 91 31932812
2004 Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies. Clinical cancer research : an official journal of the American Association for Cancer Research 89 15623599
2005 Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: consequences for signaling by VIP and PACAP. Molecular and cellular neurosciences 80 16226889
2000 Developmental regulation of pituitary adenylate cyclase-activating polypeptide and PAC(1) receptor mRNA expression in the rat central nervous system. Brain research. Developmental brain research 79 10727727
2014 PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor. Neuropeptides 73 24508136
2020 Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity. Nature cell biology 69 32341548
2009 Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor. Journal of medicinal chemistry 69 19413310
2018 PACAP38 and PAC1 receptor blockade: a new target for headache? The journal of headache and pain 63 30088106
2012 Signaling through the neuropeptide GPCR PAC₁ induces neuritogenesis via a single linear cAMP- and ERK-dependent pathway using a novel cAMP sensor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 63 22532442
1991 S. pombe pac1+, whose overexpression inhibits sexual development, encodes a ribonuclease III-like RNase. The EMBO journal 63 1989884
1996 Purification and characterization of the Pac1 ribonuclease of Schizosaccharomyces pombe. Nucleic acids research 61 8710510
2019 Targeting the PAC1 Receptor for Neurological and Metabolic Disorders. Current topics in medicinal chemistry 57 31284862
2001 Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor. Neuroreport 54 11447337
2003 Expression of the receptor for pituitary adenylate cyclase-activating polypeptide (PAC1-R) in reactive astrocytes. Brain research. Molecular brain research 53 12824050
1998 Circadian changes in PACAP type 1 (PAC1) receptor mRNA in the rat suprachiasmatic and supraoptic nuclei. Brain research 52 9824702
2007 PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells. Glia 50 17115416
2011 Quantitative analysis of Pac1/LIS1-mediated dynein targeting: Implications for regulation of dynein activity in budding yeast. Cytoskeleton (Hoboken, N.J.) 48 21294277
2014 PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling. American journal of physiology. Cell physiology 47 24696141
2013 PACAP and PAC1 receptor in brain development and behavior. Neuropeptides 47 24220567
2015 The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition. The Journal of cell biology 45 26483554
2006 Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice. The Journal of clinical investigation 45 16823490
2020 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell research 42 32047270
2020 Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nature structural & molecular biology 41 32157248
2015 A structure-function study of PACAP using conformationally restricted analogs: Identification of PAC1 receptor-selective PACAP agonists. Peptides 40 25698233
2010 PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Molecular and cellular biology 40 20498273
2007 Maxadilan, a PAC1 receptor agonist from sand flies. Peptides 40 17681401
1998 The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells: evidence by immunocytochemistry and RT-PCR. Annals of the New York Academy of Sciences 39 9928007
2010 Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects. Biochemical pharmacology 38 21114961
1997 Substrate structure requirements of the Pac1 ribonuclease from Schizosaccharmyces pombe. RNA (New York, N.Y.) 38 9326493
1997 Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library. Pharmaceutical research 38 9453052
2007 The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretion. The Journal of biological chemistry 37 17213203
2008 beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells. The Journal of biological chemistry 35 19074139
1998 Sequences within the herpesvirus-conserved pac1 and pac2 motifs are required for cleavage and packaging of the murine cytomegalovirus genome. Journal of virology 35 9420199
2016 Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities. Current medicinal chemistry 34 26630918
2005 Analysis of the role of the PAC1 receptor in neutrophil recruitment, acute-phase response, and nitric oxide production in septic shock. Journal of leukocyte biology 34 15661828
2007 An activating mutation of the Sclerotinia sclerotiorum pac1 gene increases oxalic acid production at low pH but decreases virulence. Molecular plant pathology 33 20507525
2000 Mice with markedly reduced PACAP (PAC(1)) receptor expression by targeted deletion of the signal peptide. Journal of neurochemistry 32 11032869
2013 Pro- and anti-mitogenic actions of pituitary adenylate cyclase-activating polypeptide in developing cerebral cortex: potential mediation by developmental switch of PAC1 receptor mRNA isoforms. The Journal of neuroscience : the official journal of the Society for Neuroscience 31 23447598
2007 pH and Pac1 control development and antifungal activity in Trichoderma harzianum. Fungal genetics and biology : FG & B 31 17881256
2015 iRhom1 regulates proteasome activity via PAC1/2 under ER stress. Scientific reports 30 26109405
2000 Differential activation of phospholipase D by VPAC and PAC1 receptors. Annals of the New York Academy of Sciences 30 11193821
2021 A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 33637560
2021 PAC1 Receptor Internalization and Endosomal MEK/ERK Activation Is Essential for PACAP-Mediated Neuronal Excitability. Journal of molecular neuroscience : MN 28 33675454
2018 In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor. The Journal of pharmacology and experimental therapeutics 28 29363578
2015 Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 26424889
2002 Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus. Brain research. Molecular brain research 27 12399105
1995 Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease. Molecular & general genetics : MGG 27 7616961
2014 PACAP and PAC₁ receptor in the reproductive cycle of male lizard Podarcis sicula. General and comparative endocrinology 26 24852351
2018 PACAP-Induced PAC1 Receptor Internalization and Recruitment of Endosomal Signaling Regulate Cardiac Neuron Excitability. Journal of molecular neuroscience : MN 25 30054797
2015 Doxycycline exerted neuroprotective activity by enhancing the activation of neuropeptide GPCR PAC1. Neuropharmacology 25 26700245
2006 Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) are positioned to modulate afferent signaling in the cochlea. Neuroscience 25 16876955
1997 Differential regulation of the dual-specificity protein-tyrosine phosphatases CL100, B23, and PAC1 in mesangial cells. Journal of the American Society of Nephrology : JASN 23 9013447
2009 Role of the PACAP-PAC1-DISC1 and PACAP-PAC1-stathmin1 systems in schizophrenia and bipolar disorder: novel treatment mechanisms? Pharmacogenomics 22 19958095
1997 Induction of the dual specificity phosphatase PAC1 in rat brain following seizure activity. Neuroreport 22 9331917
2016 The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration. Journal of molecular neuroscience : MN 21 27566170
2005 PAC1 receptors mediate pituitary adenylate cyclase-activating polypeptide- and progesterone-facilitated receptivity in female rats. Molecular endocrinology (Baltimore, Md.) 21 15976009
2014 The selective PAC1 receptor agonist maxadilan inhibits neurogenic vasodilation and edema formation in the mouse skin. Neuropharmacology 20 24973707
2013 Pituitary adenylate cyclase-activating peptide induces neurite outgrowth in cultured monkey trigeminal ganglion cells: involvement of receptor PAC1. Molecular vision 20 23378731
2018 PAC1 Receptors: Shapeshifters in Motion. Journal of molecular neuroscience : MN 19 30074173
2004 FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN. Cellular signalling 19 14607277
2000 Desensitization, surface expression, and glycosylation of a functional, epitope-tagged type I PACAP (PAC(1)) receptor. Biochimica et biophysica acta 19 11118531
2014 Dimer-dependent intrinsic/basal activity of the class B G protein-coupled receptor PAC1 promotes cellular anti-apoptotic activity through Wnt/β-catenin pathways that are associated with dimer endocytosis. PloS one 18 25426938
2005 Cloning and characterization of a PAC1 receptor hop-1 splice variant in goldfish (Carassius auratus). General and comparative endocrinology 18 16225877
2004 Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic beta-cells are mediated by VPAC2 and PAC1 receptors. Regulatory peptides 18 15518905
2021 Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis. Neurobiology of disease 17 34610465
2020 Pituitary adenylate cyclase-activating polypeptide-induced PAC1 receptor internalization and recruitment of MEK/ERK signaling enhance excitability of dentate gyrus granule cells. American journal of physiology. Cell physiology 17 32186931
2020 Intrabladder PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in Mice Exposed to Repeated Variate Stress (RVS). Journal of molecular neuroscience : MN 17 32613552
2019 Acquisition of class C β-lactamase PAC-1 by ST664 strains of Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy 17 31527025
2019 Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. European journal of medicinal chemistry 17 31771828
2018 PACAP/PAC1 Expression and Function in Micturition Pathways. Journal of molecular neuroscience : MN 17 30259317
2018 The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice. Journal of pharmacological sciences 17 30552012
2015 Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis. Journal of cellular and molecular medicine 17 25754465
2020 Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior. Scientific reports 16 32533011
2017 Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys. Neurotoxicity research 16 29230633
2015 Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics. Journal of medicinal chemistry 16 25856364
2014 Calcium influx, but not intracellular calcium release, supports PACAP-mediated ERK activation in HEK PAC1 receptor cells. Journal of molecular neuroscience : MN 16 24723666
2014 Novel peptide VIP-TAT with higher affinity for PAC1 inhibited scopolamine induced amnesia. Peptides 16 25086267
2013 PAC1-expressing structures of neural retina alter their PAC1 isoform splicing during postnatal development. Cell and tissue research 16 24352804
2011 Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway. Microvascular research 16 22036674
2007 Persistence of duplicated PAC1 receptors in the teleost, Sparus auratus. BMC evolutionary biology 16 17997850
1999 Structural motifs of pituitary adenylate cyclase-activating polypeptide (PACAP) defining PAC1-receptor selectivity. Regulatory peptides 16 10100920
1999 Identification and functional properties of the pituitary adenylate cyclase activating peptide (PAC1) receptor in human benign hyperplastic prostate. Cellular signalling 16 10617284
2018 PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides 15 30273693
2017 PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women. Neuropsychiatric disease and treatment 15 28652748
2016 Altered Circadian Food Anticipatory Activity Rhythms in PACAP Receptor 1 (PAC1) Deficient Mice. PloS one 15 26757053
2009 Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation. Journal of vascular research 15 19176972
2008 Granule cell survival is deficient in PAC1-/- mutant cerebellum. Journal of molecular neuroscience : MN 15 18409023