Affinage

PFDN6

Prefoldin subunit 6 · UniProt O15212

Round 2 corrected
Length
129 aa
Mass
14.6 kDa
Annotated
2026-04-29
78 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PFDN6 is a β-subunit of the heterohexameric prefoldin chaperone complex that captures non-native actin and tubulin via its tentacle tips and delivers them to the cytosolic chaperonin TRiC/CCT for productive folding (PMID:9630229, PMID:14634002). When not incorporated into the hexamer, monomeric PFDN6 is degraded by the ubiquitin–proteasome system, and co-assembly with partner subunits provides mutual stabilization (PMID:21478150). PFDN6 also serves as a β-subunit of the URI prefoldin-like complex and selectively associates with the URI/Bud27 α-subunit (PMID:30484155, PMID:30484156). Loss of PFDN6 in cancer cells attenuates proliferation and migration through impaired AKT signalling and altered transcriptional regulation of ZNF575, while in Drosophila neurons its depletion exacerbates Tau-mediated neurodegeneration (PMID:36300673, PMID:39944471, PMID:41533771).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1992 Medium

    Mapping PFDN6 (HKE2) to the MHC class II centromeric region established its genomic context before its biochemical function was known, raising the question of whether it played an immune-related role.

    Evidence Cosmid cloning and pulsed-field gel electrophoresis in human genomic DNA

    PMID:1541487 PMID:9205114

    Open questions at the time
    • Function was entirely unknown from mapping alone
    • MHC-region location suggested immune relevance that was never substantiated
  2. 1998 High

    Reconstitution of the prefoldin hexamer and yeast deletion studies established that PFDN6 is a core subunit of a chaperone that captures unfolded actin and tubulin and delivers them to TRiC/CCT, resolving the gene's primary molecular function.

    Evidence Biochemical reconstitution, co-immunoprecipitation, and S. cerevisiae gene deletion with cytoskeletal phenotypic readouts

    PMID:9630229

    Open questions at the time
    • Individual contribution of PFDN6 versus other subunits to substrate binding was not dissected
    • In vivo mammalian loss-of-function not yet performed
  3. 2003 High

    Demonstrating that prefoldin can self-assemble from six individually expressed recombinant subunits and that distal tentacle tips mediate target binding revealed the structural basis of substrate recognition, implicating PFDN6's coiled-coil tips in client capture.

    Evidence In vitro reconstitution from recombinant subunits with engineered deletions and binary complex assays using actin and tubulin

    PMID:14634002

    Open questions at the time
    • Atomic-resolution structure of PFDN6 within the complex not yet determined
    • Relative contribution of PFDN6 tentacle versus other β-subunit tentacles to each substrate unclear
  4. 2011 High

    Showing that individual prefoldin subunits including PFDN6 are degraded by the UPS unless stabilized by co-assembly with partner subunits established a quality-control mechanism ensuring stoichiometric hexamer assembly.

    Evidence siRNA knockdown, MG132 proteasome inhibition, co-transfection of subunit combinations, immunoblotting in human cells

    PMID:21478150

    Open questions at the time
    • Identity of the E3 ubiquitin ligase targeting free PFDN6 is unknown
    • Whether the degradation mechanism differs for α- versus β-subunits was not resolved
  5. 2018 Medium

    Identification of PFDN6 as a β-subunit of the URI prefoldin-like complex, and the selective interaction between its yeast orthologue Pfd6 and URI/Bud27, revealed that PFDN6 participates in a second prefoldin-related assembly with distinct composition.

    Evidence Co-immunoprecipitation in yeast and mammalian cells; selective binding tested against multiple prefoldin subunits

    PMID:30484155 PMID:30484156

    Open questions at the time
    • Functional consequences of PFDN6 incorporation into the URI complex versus the canonical prefoldin hexamer are undefined
    • No structural model of the URI prefoldin-like complex exists
    • Single co-IP approach without independent biochemical validation of selectivity
  6. 2022 Medium

    PFDN6 knockdown in glioma cells revealed a pro-tumorigenic role mediated through AKT signalling, establishing a cancer-relevant function beyond cytoskeletal protein folding.

    Evidence siRNA knockdown, CCK-8/Celigo viability, flow cytometry, wound-healing/transwell assays, xenograft mouse model, phospho-kinase array

    PMID:36300673

    Open questions at the time
    • Whether AKT activation is a direct effect of PFDN6 or secondary to cytoskeletal/chaperone dysfunction is unclear
    • Not independently replicated in a second lab
  7. 2024 Medium

    RNA-seq after PFDN6 knockdown in colorectal cancer cells identified ZNF575 as a downstream transcriptional target, extending PFDN6's cancer relevance to transcriptional regulation.

    Evidence siRNA knockdown, transcriptome sequencing (RNA-seq), cell viability/apoptosis/migration assays in HCT-116 and RKO cells

    PMID:39944471

    Open questions at the time
    • Mechanism by which PFDN6 regulates ZNF575 transcription is not established
    • Single lab study without in vivo validation
  8. 2024 Medium

    A Drosophila genetic modifier screen linked PFDN6 to Tau-mediated neurodegeneration, showing that its loss enhances Tau cytotoxicity and connecting prefoldin chaperone function to proteostasis in neurons.

    Evidence Drosophila RNAi modifier screen with hTauV337M-induced ommatidial degeneration phenotype

    PMID:41533771

    Open questions at the time
    • Whether PFDN6 directly binds or folds Tau, or acts indirectly through tubulin/actin proteostasis, is unknown
    • Mammalian neuronal validation is lacking
  9. 2024 High

    Characterization of P. falciparum PfPFD-6 revealed interaction with Kelch13 (artemisinin-resistance protein), and yeast complementation confirmed a causative role for PfPFD6 in artemisinin resistance, demonstrating functional conservation and parasite-specific chaperone clients.

    Evidence IP-MS/MS, biophysical interaction assays, yeast pfd6 mutant complementation, ring survival assay, drug inhibition with Biperiden

    PMID:38925325

    Open questions at the time
    • Whether human PFDN6 interacts with Kelch13 orthologues is unknown
    • Structural basis of Biperiden-mediated disruption not resolved
  10. 2025 High

    RNAi silencing of PFDN6 in Anopheles mosquitoes reduced P. falciparum oocyst loads by compromising epithelial and extracellular matrix integrity and triggering anti-Plasmodium immune priming, establishing an in vivo host-side role for the prefoldin-TRiC axis in vector-parasite interactions.

    Evidence RNAi gene silencing and antibody co-feeding in mosquitoes, oocyst quantification, epithelial integrity and immune assays

    PMID:40050397

    Open questions at the time
    • Whether the effect is specific to PFDN6 or generic to any prefoldin subunit knockdown is not resolved
    • Mammalian epithelial relevance not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of the E3 ligase targeting monomeric PFDN6 for proteasomal degradation, the structural basis of PFDN6 within both the canonical prefoldin and URI prefoldin-like complexes, and the mechanism by which PFDN6 influences AKT signalling and ZNF575 transcription in cancer cells.
  • No E3 ligase identified for monomeric PFDN6 degradation
  • No high-resolution structure of PFDN6 in either complex
  • Mechanistic link between PFDN6 and AKT/ZNF575 transcription not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0044183 protein folding chaperone 3
Localization
GO:0005829 cytosol 2
Pathway
R-HSA-1643685 Disease 2 R-HSA-162582 Signal Transduction 1
Partners
PFDN1PFDN2PFDN3PFDN4PFDN5STAP1URI1
Complex memberships
Prefoldin complex (PFD hexamer)URI prefoldin-like complex

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Prefoldin (PFD) is a heterohexameric chaperone that captures unfolded actin and transfers target proteins to the cytosolic chaperonin (c-cpn/TRiC) for folding; deletion of a prefoldin subunit gene in S. cerevisiae impairs actin- and tubulin-based cytoskeleton function, phenocopying c-cpn mutations. PFD6 is one of the six constituent subunits of this complex. Biochemical reconstitution, co-immunoprecipitation, S. cerevisiae gene deletion with cytoskeletal phenotypic readout Cell High 9630229
1992 The human gene HKE2 (later identified as PFDN6) was mapped to the MHC class II centromeric region, approximately 170 kb centromeric of HKE4, as a homolog of mouse KE2 located in the H-2K region. Cosmid cloning, pulsed-field gel electrophoresis, genomic mapping Immunogenetics Medium 1541487
1997 Physical mapping of the MHC centromeric region established the gene order HSET-HKE1.5-HKE2-HKE3-RING1-HKE6-HKE4; HKE2 (PFDN6) encodes a transcript detectable in multiple tissues and is located ~170 kb centromeric of HKE4. Cosmid contig construction, shotgun DNA sequencing, exon-intron organization determination Genomics Medium 9205114
2003 Functional eukaryotic prefoldin (PFD) can spontaneously assemble from all six individually expressed recombinant subunits (PFD1–PFD6). The distal tips of PFD tentacles are required for binary complex formation with target proteins (actin, α-tubulin, β-tubulin), and different but overlapping sets of subunits mediate binding to distinct targets, indicating that PFD6 participates in the tentacle tips involved in target recognition. In vitro reconstitution from recombinant subunits, engineered deletion forms, binary complex assays with authentic actin and tubulin The Journal of biological chemistry High 14634002
2007 HKE2 (PFDN6) protein is expressed cytoplasmically and is dramatically upregulated upon cellular activation; immunohistochemical analysis of tissue microarrays showed overexpression in certain cancers, and the gene's MHC class II location and putative protein-binding domain suggest a role in adaptive immunity. Immunohistochemistry using anti-HKE2 antibody, tissue microarray analysis Tissue antigens Medium 17257322
2011 Individual PFD subunits (including PFD6) are degraded by the ubiquitin-proteasome system (UPS) when expressed as monomers; co-expression with specific partner subunits stabilizes individual subunits against UPS-mediated degradation. Knockdown of one subunit decreases protein levels of other subunits, demonstrating mutual regulation of protein levels within the prefoldin hexamer. siRNA knockdown, proteasome inhibitor (MG132) treatment, co-transfection of subunit combinations, immunoblotting The Journal of biological chemistry High 21478150
2018 PFDN6 (along with PFDN2 and PFDN4r) is a β-subunit component of the URI prefoldin-like complex, a heterohexameric chaperone complex (α2β4) in which URI and STAP1 are the α-subunits. This complex was identified by immunoprecipitation with SKP2. Immunoprecipitation, co-complex identification, literature synthesis of original co-IP experiments Advances in experimental medicine and biology Medium 30484155
2018 In yeast, Bud27 (URI orthologue) interacts with Pfd6 (PFDN6 orthologue) but not with other components of the R2TP/PFDL complex, indicating that among prefoldin subunits, Bud27 selectively associates with Pfd6 within yeast prefoldin-like assemblies. Protein interaction studies, co-immunoprecipitation in yeast Advances in experimental medicine and biology Medium 30484156
2022 P. falciparum PfPFD-6 is significantly expressed at trophozoite and schizont stages; pull-down assays demonstrated a direct interaction between PfPFD-6 and merozoite surface protein-1 (MSP-1), and in silico analysis identified critical residues mediating this interaction, suggesting a role in stabilizing or trafficking MSP-1. Pull-down assay, immunofluorescence/expression analysis across parasite stages, in silico docking analysis FEBS open bio Medium 33145997
2022 PFDN6 knockdown in glioma cell lines significantly attenuated cell proliferation and migration, induced apoptosis, and blocked cell cycle progression at G2; in vivo xenograft models confirmed these effects. A human phospho-kinase array revealed that these effects are mediated through the AKT signalling pathway, identifying PFDN6 as a pro-tumorigenic factor acting upstream of AKT. siRNA knockdown, Celigo/CCK-8 viability assays, flow cytometry (apoptosis/cell cycle), wound-healing and transwell migration assays, xenograft mouse model, phospho-kinase array Cell biology international Medium 36300673
2024 All six Plasmodium falciparum prefoldin subunits (PFD1-6) were functionally characterized; immunoprecipitation coupled MS/MS showed PfPFD-6 interacts with the artemisinin-resistance protein Kelch13. Systematic biophysical interaction analysis demonstrated all PFD subunits can form a complex. PfPFD6 expression in yeast pfd6 mutants rescued the ART-resistance phenotype, confirming a causative role for PfPFD6 in artemisinin resistance. An FDA-approved drug Biperiden disrupts prefoldin complex formation and inhibits PfPFD6 interaction with MSP-1 and α-tubulin-I. Immunoprecipitation-MS/MS, biophysical interaction assays, yeast complementation (epistasis), ring survival assay, drug inhibition studies The Journal of biological chemistry High 38925325
2025 Silencing any prefoldin subunit (including PFDN6) in Anopheles mosquitoes via RNA interference reduces P. falciparum oocyst loads in the mosquito midgut; co-feeding mosquitoes with PFDN6-specific antibody and gametocytes also reduced infection. Inhibition of the PFDN-CCT/TRiC chaperonin complex caused loss of epithelial and extracellular matrix integrity, triggering anti-Plasmodium immune priming and compromising the parasite's laminin-based immune evasion. RNAi gene silencing, antibody co-feeding assay, oocyst load quantification, epithelial integrity and immune assays Nature microbiology High 40050397
2024 PFDN6 knockdown in colorectal cancer cell lines (HCT-116 and RKO) reduced tumour cell number, promoted apoptosis, and inhibited migration and invasion; transcriptome sequencing after PFDN6 knockdown identified ZNF575 as a downstream transcriptional target, revealing a role for PFDN6 in regulating CRC development via transcriptional regulation of ZNF575. siRNA knockdown, transcriptome sequencing (RNA-seq), cell viability/apoptosis/migration assays, bioinformatics pathway analysis eGastroenterology Medium 39944471
2024 A Drosophila genetic screen identified Pfdn5 and Pfdn6 as strong modifiers of hTauV337M-induced eye-ommatidial degeneration; RNAi knockdown of Pfdn6 enhanced Tau cytotoxicity, linking prefoldin 6 function to modulation of Tau aggregation and neurodegeneration in vivo. Drosophila RNAi genetic modifier screen, eye-ommatidial degeneration phenotypic readout, hTau overexpression model bioRxiv (preprint) / eLife Medium 41533771

Source papers

Stage 0 corpus · 78 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2016 An improved smaller biotin ligase for BioID proximity labeling. Molecular biology of the cell 665 26912792
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1998 Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 443 9630229
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2010 Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (New York, N.Y.) 421 20360068
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1996 Normalization and subtraction: two approaches to facilitate gene discovery. Genome research 401 8889548
2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science signaling 383 24255178
2007 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular cell 367 17643375
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2022 CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1. Oncogene 259 36369321
2022 Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell 256 35063084
2013 The functional interactome landscape of the human histone deacetylase family. Molecular systems biology 235 23752268
2009 An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Molecular systems biology 223 19156129
2016 A High-Density Map for Navigating the Human Polycomb Complexome. Cell reports 216 27705803
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2020 Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure. Circulation. Heart failure 127 33356362
2019 Ketone ester supplementation blunts overreaching symptoms during endurance training overload. The Journal of physiology 90 31039280
1999 On the role of kerato-epithelin in the pathogenesis of 5q31-linked corneal dystrophies. Investigative ophthalmology & visual science 74 10476785
1995 Structural hierarchy in the clustering of HLA class I molecules in the plasma membrane of human lymphoblastoid cells. Proceedings of the National Academy of Sciences of the United States of America 73 7862646
1997 Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity. Journal of medicinal chemistry 67 9301674
2003 Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding. The Journal of biological chemistry 56 14634002
1998 TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. Journal of molecular biology 48 9545376
2008 Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 46 19004800
2001 X-ray crystal structures of alpha-KrF(2),[KrF][MF(6)](M=As,Sb,Bi),[Kr(2)F(3)][SbF(6).KrF(2), [Ke(2)F(3)2[SbF(6)]2.KrF(2), and [Kr(2)F(3)][AsF(6)].[KrF][AsF(6)]; synthesis and characterization of [Kr(2)F(3)][PF(6).nKrF(2); and theoretical studies of KrF(2), KrF+, Kr(2)F(3)+, and the [KrF][MF(6)](M=P,As,Sb,Bi) ion pairs. Inorganic chemistry 44 11399167
2017 Adenosine A1 Receptor Antagonism Abolished the Anti-seizure Effects of Exogenous Ketone Supplementation in Wistar Albino Glaxo Rijswijk Rats. Frontiers in molecular neuroscience 43 28790891
2000 Immunohistology of kerato-epithelin in corneal stromal dystrophies associated with R124 mutations of the BIGH3 gene. Current eye research 35 11262611
1992 Search for MHC-associated genes in human: five new genes centromeric to HLA-DP with yet unknown functions. Immunogenetics 33 1541487
1997 Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes. Genomics 26 9205114
2016 Identification of potential predictive markers of dexamethasone resistance in childhood acute lymphoblastic leukemia. Journal of cell communication and signaling 25 27778231
2017 Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC pharmacology & toxicology 23 28577368
2015 Low-intensity eccentric contractions of the knee extensors and flexors protect against muscle damage. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 23 26319562
2011 Prefoldin subunits are protected from ubiquitin-proteasome system-mediated degradation by forming complex with other constituent subunits. The Journal of biological chemistry 22 21478150
2023 Prediction of zebrafish embryonic developmental toxicity by integrating omics with adverse outcome pathway. Journal of hazardous materials 21 36860045
2002 Interaction of the membrane-inserted diphtheria toxin T domain with peptides and its possible implications for chaperone-like T domain behavior. Biochemistry 21 11863463
2021 WGCNA-Based Identification of Hub Genes and Key Pathways Involved in Nonalcoholic Fatty Liver Disease. BioMed research international 20 34938809
2019 Design, synthesis and biological evaluation of 4-aminoquinoline-guanylthiourea derivatives as antimalarial agents. Bioorganic chemistry 19 31376783
2019 The 21st Century movement within the area of skin sensitization assessment: From the animal context towards current human-relevant in vitro solutions. Regulatory toxicology and pharmacology : RTP 19 31430506
2011 Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways. Proceedings of the National Academy of Sciences of the United States of America 19 21482803
2021 Identification of the susceptibility genes for COVID-19 in lung adenocarcinoma with global data and biological computation methods. Computational and structural biotechnology journal 17 34840672
2017 Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17 28096231
2008 A corneal dystrophy associated with transforming growth factor beta-induced Gly623Asp mutation an amyloidogenic phenotype. Ophthalmology 16 19019446
2020 Inhibition of 5-Lipoxygenase-Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins. Molecular nutrition & food research 13 32306507
2018 Roles and Functions of the Unconventional Prefoldin URI. Advances in experimental medicine and biology 13 30484155
2018 The Yeast Prefoldin Bud27. Advances in experimental medicine and biology 11 30484156
2007 Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. Tissue antigens 11 17257322
2022 Identification of combined biomarkers for predicting the risk of osteoporosis using machine learning. Aging 9 35580864
2020 Proteome alterations associated with the oleic acid and cis-9, trans-11 conjugated linoleic acid content in bovine skeletal muscle. Journal of proteomics 8 32335295
2020 Multiple immunity-related genes control susceptibility of Arabidopsis thaliana to the parasitic weed Phelipanche aegyptiaca. PeerJ 8 32551199
2023 The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis. The Journal of biological chemistry 7 36813233
2020 α-Sens: The improved ARE-Nrf2-based sensitization screening assay using normalized transcriptional activity. Toxicology 6 32335162
1989 Electrophysiological interactions between carbachol and class I antiarrhythmic drugs (lidocaine, quinidine)--experimental studies in rabbit atrial myocardium. Basic research in cardiology 5 2923607
2022 Prefoldin subunit 6 of Plasmodium falciparum binds merozoite surface protein-1. FEBS open bio 4 33145997
2022 The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis. Journal of integrative plant biology 4 35943836
1994 [Activity of alanine- and aspartate-aminotransferases in organs of albino rats subjected to whole body gamma-irradiation and physical exercise]. Radiatsionnaia biologiia, radioecologiia 4 7951896
2023 AOP Report: Glutathione Conjugation Leading to Reproductive Dysfunction via Oxidative Stress. Environmental toxicology and chemistry 3 37849373
2022 Prefoldin 6 promotes glioma progression via the AKT signalling pathway. Cell biology international 2 36300673
2025 Targeting the mosquito prefoldin-chaperonin complex blocks Plasmodium transmission. Nature microbiology 1 40050397
2024 Assessment of the mode of action of perchloroethylene-induced mouse liver tumors. Toxicology and industrial health 1 38523547
2024 Prefoldins are novel regulators of the unfolded protein response in artemisinin resistant Plasmodium falciparum malaria. The Journal of biological chemistry 1 38925325
2020 An evaluation of the genetic conditioning of evoking pain. Annals of agricultural and environmental medicine : AAEM 1 32588605
2026 Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity. eLife 0 41533771
2024 PFDN6 contributes to colorectal cancer progression via transcriptional regulation. eGastroenterology 0 39944471
1993 [A case of advanced gastric cancer with liver and lung metastasis effectively treated by combined chemo-immunotherapy of MMC, 5'-DFUR, OK-432]. Gan to kagaku ryoho. Cancer & chemotherapy 0 8333751