Affinage

PFDN4

Prefoldin subunit 4 · UniProt Q9NQP4

Audit flag: wrong gene
Length
134 aa
Mass
15.3 kDa
Annotated
2026-06-10
100 papers in source corpus

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

No mechanistic discoveries found in literature.

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Protists decrease in size linearly with temperature: ca. 2.5% degrees C(-1). Proceedings. Biological sciences 143 14728784
1992 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. Journal of medicinal chemistry 137 1732526
2011 Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. The Proceedings of the Nutrition Society 114 22124338
2019 From Solar Energy to Fuels: Recent Advances in Light-Driven C1 Chemistry. Angewandte Chemie (International ed. in English) 107 30825253
1972 The purification and properties of the C 1 component of Trichoderma koningii cellulase. The Biochemical journal 102 4674624
1994 Tissue-differential expression of two distinct genes for human IMP dehydrogenase (E.C.1.1.1.205). Life sciences 90 7910933
2022 Electrocatalytic Hydrogenation Boosts Reduction of Nitrate to Ammonia over Single-Atom Cu with Cu(I)-N3C1 Sites. Environmental science & technology 89 36175172
1965 C'1 ESTERASE EFFECT ON ACTIVITY AND PHYSICOCHEMICAL PROPERTIES OF THE FOURTH COMPONENT OF COMPLEMENT. The Journal of experimental medicine 88 14280442
1994 Mutation of the gene encoding protein kinase C 1 stimulates mitotic recombination in Saccharomyces cerevisiae. Molecular and cellular biology 77 8065337
1997 Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines. Biochemistry 73 9054552
2009 Deficiency of niemann-pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartments. Journal of virology 72 19474101
2014 Anti-arthritic activity of N'-[(2,4-dihydroxyphenyl)methylidene]-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-1(4H)-yl)acetohydrazide. European journal of pharmacology 71 24943733
2007 Apolipoprotein C-1 maintains cell survival by preventing from apoptosis in pancreatic cancer cells. Oncogene 69 18037960
2008 Enhanced expression of phospholipase C 1 (ZmPLC1) improves drought tolerance in transgenic maize. Planta 66 18214529
2012 Enzymatic pathway for biodegrading microcystin LR in Sphingopyxis sp. C-1. Journal of bioscience and bioengineering 63 22883536
2003 Len c 1, a major allergen and vicilin from lentil seeds: protein isolation and cDNA cloning. The Journal of allergy and clinical immunology 63 14657885
2002 Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo[2,1-c][1,4]benzodiazepines as DNA-interactive antitumour antibiotics. Current medicinal chemistry. Anti-cancer agents 62 12678745
2001 Connection between poly-beta-hydroxybutyrate biosynthesis and growth on C(1) and C(2) compounds in the methylotroph Methylobacterium extorquens AM1. Journal of bacteriology 62 11208803
2010 Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates. Bioorganic & medicinal chemistry 59 20627593
2009 Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugs. Anti-cancer agents in medicinal chemistry 57 19149479
2002 Complex of human apolipoprotein C-1 with phospholipid: thermodynamic or kinetic stability? Biochemistry 55 12044170
1999 Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines. Journal of medicinal chemistry 54 10354403
2021 Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. Journal of medicinal chemistry 50 34115499
2009 Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents. Bioorganic & medicinal chemistry 49 20031423
1982 Subunit structure of oxygenase component in benzoate-1,2-dioxygenase system from Pseudomonas arvilla C-1. The Journal of biological chemistry 45 7130163
2017 Advillin acts upstream of phospholipase C ϵ1 in steroid-resistant nephrotic syndrome. The Journal of clinical investigation 43 29058690
2011 A novel specificity protein 1 (SP1)-like gene regulating protein kinase C-1 (Pkc1)-dependent cell wall integrity and virulence factors in Cryptococcus neoformans. The Journal of biological chemistry 42 21487010
1985 Stereochemistry at C-1 of geranyl pyrophosphate and neryl pyrophosphate in the cyclization to (+)- and (-)-bornyl pyrophosphate. The Journal of biological chemistry 42 3997807
2009 Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential. Bioorganic & medicinal chemistry 39 19168361
2011 Protein and metal cluster structure of the wheat metallothionein domain γ-E(c)-1: the second part of the puzzle. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 38 21437709
1981 Fate of apolipoproteins C-1, C-iii, and E during lipolysis of human very low density lipoproteins in vitro. Journal of lipid research 38 7276737
1998 Thermodynamic analysis of human plasma apolipoprotein C-1: high-temperature unfolding and low-temperature oligomer dissociation. Biochemistry 37 9477954
2021 Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region. eLife 36 34779770
2014 Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization. ChemMedChem 36 24976143
2001 [(13)C,(13)C]- and [(13)C,(1)H]-TROSY in a triple resonance experiment for ribose-base and intrabase correlations in nucleic acids. Journal of the American Chemical Society 35 11456577
2010 Characterization of expression, activity and role in antibacterial immunity of Anopheles gambiae lysozyme c-1. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 34 19932188
2003 Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation. Mini reviews in medicinal chemistry 34 12678826
1993 Synthesis and assembly of hepatitis A virus-specific proteins in BS-C-1 cells. Journal of virology 34 8388489
2008 Microtubule binding and disruption and induction of premature senescence by disorazole C(1). The Journal of pharmacology and experimental therapeutics 32 19066338
2011 Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates. Bioorganic & medicinal chemistry letters 31 22104151
2008 Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues. Journal of lipid research 31 18272928
2008 Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates. Bioorganic & medicinal chemistry 31 18657979
1998 Ric c 1 and Ric c 3, the allergenic 2S albumin storage proteins of Ricinus communis: complete primary structures and phylogenetic relationships. International archives of allergy and immunology 31 9430499
2010 DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents. ACS medicinal chemistry letters 29 24900228
2011 DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057. Investigational new drugs 28 21384134
2011 Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse. Metabolic brain disease 27 21938520
2007 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity. Bioorganic & medicinal chemistry letters 27 17723301
2022 Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage. Nature communications 26 35396511
2019 Synthesis and biological evaluation of novel benzo[c][1,2,5]thiadiazol-5-yl and thieno[3,2-c]- pyridin-2-yl imidazole derivatives as ALK5 inhibitors. Bioorganic & medicinal chemistry letters 26 31303386
2007 The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 26 17517108
1996 Characterisation of a chromosomally encoded catechol 1,2-dioxygenase (E.C. 1.13.11.1) from Alcaligenes eutrophus CH34. Archives of microbiology 26 8661943
2020 Mechanism of Antibacterial Activity of Bacillus amyloliquefaciens C-1 Lipopeptide toward Anaerobic Clostridium difficile. BioMed research international 25 32190658
2010 Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents. Journal of medicinal chemistry 25 20218628
2011 C(1) metabolism and CVD outcomes in older adults. The Proceedings of the Nutrition Society 23 22152927
2022 Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo. Food & function 22 36205648
1999 Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide. Protein science : a publication of the Protein Society 22 10548051
2023 Production of biofuels from C1 -gases with Clostridium and related bacteria-Recent advances. Microbial biotechnology 21 36661185
2023 Electrosynthesis of ethylene glycol from C1 feedstocks in a flow electrolyzer. Nature communications 21 37516779
2020 Two Reaction Modes of Pyridinium 1,4-Zwitterionic Thiolates with Sulfenes: Synthesis of 3H-1,2-Dithiole 2,2-Dioxides, 1,9a-Dihydropyrido[2,1-c][1,4]thiazines, and Indolizines. Organic letters 21 32648762
1990 Evaluation of the electrophilicity of DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines by HPLC. The Journal of antibiotics 21 2258327
2005 Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy. Bioorganic & medicinal chemistry letters 20 16290933
2024 Asymmetric Cu-N1O3 Sites Coupling Atop-type and Bridge-type Adsorbed *C1 for Electrocatalytic CO2-to-C2 Conversion. Angewandte Chemie (International ed. in English) 18 39044263
2013 Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds. Bioorganic & medicinal chemistry letters 18 24161833
2000 [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1. Nucleosides, nucleotides & nucleic acids 18 11097052
2024 Altering the CO2 Electroreduction Pathways Towards C1 or C2+ Products via Engineering the Strength of Interfacial Cu-O Bond. Angewandte Chemie (International ed. in English) 17 38880900
2021 Autotrophic (C1-gas) versus heterotrophic (fructose) accumulation of acetic acid and ethanol in Clostridium aceticum. Bioresource technology 17 34320764
2021 High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals. Cell reports 17 34982967
2001 Cytochromes c(550), c(552), and c(1) in the electron transport network of Paracoccus denitrificans: redundant or subtly different in function? Journal of bacteriology 17 11717258
2019 Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Biochimica et biophysica acta. General subjects 16 30611847
2019 Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds. Bioorganic & medicinal chemistry letters 16 31870647
2013 Distribution and functional plasticity of peripheral blood Th(c)17 and Th(c)1 in rheumatoid arthritis. Rheumatology international 16 23412693
2015 Synthesis and cytotoxic activity of novel poly-substituted imidazo[2,1-c][1,2,4]triazin-6-amines. Molecular diversity 15 25613858
2010 Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents. European journal of medicinal chemistry 15 20554354
2010 Dau c 1.01 and Dau c 1.02-silenced transgenic carrot plants show reduced allergenicity to patients with carrot allergy. Transgenic research 15 20798987
2003 Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins. Biochemistry 15 12705839
2016 Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot. Allergy 14 27222434
2005 Synthesis of some derivatives of C-(1-deoxy-1-N-substituted-D-glucopyranosyl)formic acid (D-gluco-hept-2-ulopyranosonic acid) as potential inhibitors of glycogen phosphorylase. Carbohydrate research 14 16098956
2021 Niemann-Pick Type C 1 (NPC1) and NPC2 Gene Variability in Demented Patients with Evidence of Brain Amyloid Deposition. Journal of Alzheimer's disease : JAD 13 34420959
2005 The balancing act of transcription factors C-1-1 and Runx2 in articular cartilage development. Biochemical and biophysical research communications 13 15694413
2002 Chemical activation of C(1)-C(2) spinal neurons modulates activity of thoracic respiratory interneurons in rats. American journal of physiology. Regulatory, integrative and comparative physiology 13 12228053
2024 Palladium-catalyzed Suzuki-Miyaura cross-couplings of stable glycal boronates for robust synthesis of C-1 glycals. Nature communications 12 38898022
2023 Asymmetric C1 Extension of Aldehydes through Biocatalytic Cascades for Stereodivergent Synthesis of Mandelic Acids. Angewandte Chemie (International ed. in English) 12 36929048
2022 3JC48-3 (methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth. Cancer gene therapy 12 35440696
2022 A metabolic puzzle: Consumption of C1 compounds and thiosulfate in Hyphomicrobium denitrificans XT. Biochimica et biophysica acta. Bioenergetics 12 36367491
2020 Physical contact between cytochrome c1 and cytochrome c increases the driving force for electron transfer. Biochimica et biophysica acta. Bioenergetics 12 32717223
2020 Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer. Journal of cellular physiology 12 32743796
2017 DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice. The Korean journal of parasitology 12 29103265
2016 Naphtho[2,3-c][1,2,5]thiadiazole and 2H-Naphtho[2,3-d][1,2,3]triazole-Containing D-A-π-A Conjugated Organic Dyes for Dye-Sensitized Solar Cells. ACS applied materials & interfaces 12 26891701
2011 A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. Investigational new drugs 12 21494837
2004 Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates. Bioorganic & medicinal chemistry letters 12 15012990
2023 From Biomimicking to Bioinspired Design of Electrocatalysts for CO2 Reduction to C1 Products. Angewandte Chemie (International ed. in English) 11 37795670
2020 Exploration of the Electrophilic Reactivity of the Cytotoxic Marine Alkaloid Discorhabdin C and Subsequent Discovery of a New Dimeric C-1/N-13-Linked Discorhabdin Natural Product. Marine drugs 11 32752009
2016 Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination. PloS one 11 27100886
2011 Sugar-based enantiomeric and conformationally constrained pyrrolo[2,1-c][1,4]-benzodiazepines as potential GABAA ligands. Journal of medicinal chemistry 11 21314193
2002 Incorporation of [1-(13)C]1-deoxy-D-xylulose into isoprenoids of the liverwort Conocephalum conicum. Phytochemistry 11 11830134
2000 Regulation of granulocyte colony-stimulating factor and parathyroid hormone-related protein production in lung carcinoma cell line OKa-C-1. Japanese journal of cancer research : Gann 11 11011119
2021 Troponin C-1 Activated by E2F1 Accelerates Gastric Cancer Progression via Regulating TGF-β/Smad Signaling. Digestive diseases and sciences 10 34797443
2020 Lysozyme c-1 gene is overexpressed in Anopheles albimanus pericardial cells after an immune challenge. Developmental and comparative immunology 10 32805306
2017 Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors. Bioorganic & medicinal chemistry letters 10 28351590
2017 Ectromelia virus accumulates less double-stranded RNA compared to vaccinia virus in BS-C-1 cells. Virology 10 28628829

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