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cells.","date":"2017","source":"Virology","url":"https://pubmed.ncbi.nlm.nih.gov/28628829","citation_count":10,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":49922,"output_tokens":276,"usd":0.076953,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.076953,"stage1_batch_id":"msgbatch_013a8chtv3AWyTqv4z4sEF4C","stage2_batch_id":"msgbatch_01AHsuW63vinsvuTgzmQ3n62","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking through the 100 papers, I need to identify which ones are actually about PFDN4 (Prefoldin subunit 4, also known as PFD4 or C-1).\n\nAfter carefully reviewing all abstracts:\n\n- Paper [81] mentions PFDN4 by name in the context of colorectal cancer expression, but this is purely an expression/biomarker study with no mechanistic findings about the PFDN4 protein itself.\n- No other papers describe the canonical PFDN4 prefoldin subunit protein with any mechanistic experiments.\n\nThe vast majority of papers are about completely different proteins, chemical compounds, organisms, or phenomena that share symbol collisions (C-1 as a chemical descriptor, NPC-1/NPC1 as Niemann-Pick, apolipoprotein C-1, various biological C-1 entities, etc.). None of these are orthologs or mechanistic studies of PFDN4/prefoldin subunit 4.\n\n```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings about PFDN4 (Prefoldin subunit 4) are present in the available literature corpus.\"\n}\n```","stage2_raw":"","audit_flag":{"gene":"PFDN4","tier":"IDENTITY","verdict":"Identity concern","subtype":"corpus_ungrounded","uniprot_band":"medium","rules_fired":"R1,R5","issue":"R1: gene named in 24/100 (24%) of its own corpus abstracts (< 25%) — corpus likely a paralog/alias collision; R5: no narrative despite experimental UniProt FUNCTION (227 chars) and on-target evidence in corpus (26 on-target corpus titles)"},"evaluation":null}