Affinage

PES1

Pescadillo homolog · UniProt O00541

Length
588 aa
Mass
68.0 kDa
Annotated
2026-06-10
100 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PES1 (Pescadillo) is a nucleolar protein that functions as a core subunit of the trimeric PeBoW complex with Bop1 and WDR12, where it directs maturation of 36S/32S pre-rRNA precursors into mature 28S and 5.8S rRNAs and supports 60S subunit assembly and cell proliferation (PMID:15225545, PMID:16043514, PMID:16738141, PMID:17353269). Its BRCT domain is required for nucleolar localization, protein stability, and incorporation into the PeBoW complex; loss of this domain produces diffuse nucleoplasmic distribution and failure to rescue rRNA processing (PMID:17189298). PES1 occupies the dense fibrillar component of the nucleolus and redistributes to the nucleoplasm upon DNA damage (PMID:25557119), and its nucleolar retention depends on partners including B23/nucleophosmin and is antagonized by Mtap1b-LC1, which sequesters PES1 to the cytoplasm (PMID:17308336, PMID:20011973). Studies of the yeast Nop7/Erb1/Ytm1 subcomplex establish that these orthologs assemble interdependently into consecutive 66S preribosomes through defined interaction domains (PMID:16287855, PMID:18448671). Beyond ribosome biogenesis, PES1 directly binds TERT to promote telomerase assembly with telomerase RNA, sustaining telomerase activity and preventing telomere shortening and senescence (PMID:31106266). PES1 also acts as an oncogenic effector: it differentially controls estrogen receptor signaling by stabilizing ERα and destabilizing ERβ through CHIP-mediated ubiquitin-proteasome regulation, and is itself stabilized by SUMOylation at K517 which suppresses its ubiquitination (PMID:22820289, PMID:27409667). PES1 transcription is driven by JNK/c-Jun and by BRD4, and PES1 interacts with BRD4 to sustain c-Myc expression and BET-inhibitor resistance (PMID:22860098, PMID:30172011, PMID:31718704). Additional roles include binding β-catenin to strengthen β-catenin/TCF4 signaling (PMID:30319277) and supporting nuclear RAD51 accumulation and DNA repair capacity (PMID:23333390).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2004 High

    Established that mammalian Pes1 acts in pre-rRNA processing by physically partnering with Bop1, defining a functional unit for 28S/5.8S rRNA maturation.

    Evidence Reciprocal Co-IP, dominant mutant and rRNA processing assays in mouse cells

    PMID:15225545

    Open questions at the time
    • Third subunit and full complex composition not yet defined
    • No structural basis for the Pes1-Bop1 interaction
  2. 2005 High

    Resolved the complex composition by showing Pes1/Bop1 form a stable trimer with WDR12 (PeBoW) required for 32S processing and proliferation, linking ribosome biogenesis to p53-dependent cell-cycle control.

    Evidence Co-IP, dominant-negative WDR12 expression, rRNA and p53/p19ARF genetic analysis

    PMID:16043514

    Open questions at the time
    • How rRNA processing failure signals to p53 not defined
    • Subunit assembly order not yet mapped
  3. 2006 High

    Defined that Pes1's dominant-negative activity and rRNA processing function require correct PeBoW incorporation, and that the BRCT domain governs nucleolar localization and stability.

    Evidence Deletion and point mutants, Co-IP, immunofluorescence, knockdown-rescue rRNA assays

    PMID:16738141 PMID:17189298

    Open questions at the time
    • BRCT ligand/binding partner not identified
    • Structural model of PeBoW assembly absent
  4. 2007 High

    Reconstituted the PeBoW complex and established assembly hierarchy, showing Bop1 is central and its nucleolar transport is Pes1-dependent while Pes1 localizes independently.

    Evidence Recombinant reconstitution, siRNA epistasis, fractionation, sucrose gradients

    PMID:17353269

    Open questions at the time
    • Enzymatic activity of the complex not defined
    • How the complex is released from mature ribosomes unknown
  5. 2008 High

    Yeast ortholog studies clarified that Nop7/Erb1/Ytm1 assemble interdependently into consecutive 66S preribosomes via discrete interaction domains, providing the conserved mechanistic framework for PeBoW.

    Evidence Affinity purification, Co-IP, domain truncation, dominant-negative genetics, export and rRNA assays in yeast

    PMID:16287855 PMID:18448671

    Open questions at the time
    • Direct mapping of human domain requirements to yeast not fully tested
    • Mechanism of preribosome release not resolved
  6. 2009 Medium

    Identified B23/nucleophosmin and Mtap1b-LC1 as regulators of PES1 subcellular distribution, showing nucleolar retention is actively controlled.

    Evidence Endogenous Co-IP, pulldown domain mapping, yeast two-hybrid, knockdown and localization assays

    PMID:17308336 PMID:20011973

    Open questions at the time
    • Whether these interactions affect rRNA processing not tested
    • Single-lab findings without reciprocal validation across studies
  7. 2012 High

    Extended PES1 beyond the nucleolus into estrogen signaling and transcriptional control, showing it differentially stabilizes ERα/ERβ via CHIP and is induced by JNK/c-Jun, placing it in oncogenic pathways.

    Evidence Reporter, Co-IP, ubiquitination, proteasome inhibition, xenograft, ChIP and EMSA

    PMID:22820289 PMID:22860098

    Open questions at the time
    • How a nucleolar protein engages cytoplasmic/nuclear receptor turnover unclear
    • Direct vs indirect role in CHIP recruitment not resolved
  8. 2016 High

    Showed PES1 is itself stabilized by SUMOylation at K517, which suppresses ubiquitination and reinforces ERα-driven proliferation, defining a post-translational control loop.

    Evidence SUMOylation assays, K517R mutagenesis, ubiquitination assays, estrogen treatment, cell cycle and xenograft

    PMID:27409667

    Open questions at the time
    • SUMO E3 ligase for PES1 not identified
    • Crosstalk with PeBoW function not tested
  9. 2019 High

    Revealed a telomere-maintenance function: PES1 directly binds TERT and promotes telomerase assembly with TR, distinct from known telomerase chaperones.

    Evidence Co-IP, direct interaction assays, TRAP, telomere length and senescence assays with explicit negative controls

    PMID:31106266

    Open questions at the time
    • Structural basis of PES1-TERT contact unknown
    • Whether nucleolar PeBoW role is separable from telomerase role untested
  10. 2019 Medium

    Connected PES1 to BRD4-driven oncogenic transcription, showing PES1-BRD4 interaction sustains c-Myc and BET-inhibitor resistance, with CDK5 inhibition destabilizing PES1.

    Evidence Co-IP, BRD4/CDK5 inhibitor experiments, glycolysis gene profiling, BET resistance assays, xenograft

    PMID:30172011 PMID:31718704

    Open questions at the time
    • Direct mechanism by which PES1 enhances c-Myc transcription not defined
    • Single-lab findings of limited mechanistic depth
  11. 2021 Medium

    Defined the ubiquitin-proteasome control of PES1, identifying Trim23 as its E3 ligase whose action is blocked by lncRNA SNHG17.

    Evidence RNA pull-down, RIP, Co-IP, ubiquitination assays, SNHG17 manipulation

    PMID:34782005

    Open questions at the time
    • Trim23 ubiquitination site on PES1 not mapped
    • Relationship to SUMO-mediated stabilization untested
  12. 2023 Medium

    Expanded PES1 into immune evasion by showing it binds ILF3 to disrupt IL15 mRNA stabilization, reducing CD8+ T cell infiltration.

    Evidence Mass spectrometry, Co-IP, PLA, RIP, mRNA stability and RNA-seq, knockdown in vitro and in vivo

    PMID:36959575

    Open questions at the time
    • Whether PES1 directly binds RNA or only ILF3 unclear
    • Single-lab finding without reciprocal validation

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PES1's core nucleolar ribosome-biogenesis function mechanistically connects to its diverse extranucleolar oncogenic roles (telomerase, ER signaling, BRD4/c-Myc, Wnt, DNA repair, immune evasion) remains unresolved.
  • No unified model linking nucleolar and extranucleolar pools of PES1
  • No structural data for non-PeBoW interactions
  • Stimulus-dependent partitioning between functions uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0140098 catalytic activity, acting on RNA 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005730 nucleolus 5 GO:0005634 nucleus 2 GO:0005654 nucleoplasm 2
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-1640170 Cell Cycle 3 R-HSA-73894 DNA Repair 1
Partners
BOP1BRD4CTNNB1ILF3MAP1BNPM1TERTWDR12
Complex memberships
Nop7 subcomplex (Nop7/Erb1/Ytm1, yeast)PeBoW complex (PES1/Bop1/WDR12)telomerase (PES1/TERT/TR)

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Pes1 (mouse homolog of zebrafish Pescadillo/yeast Nop7p) physically interacts with the nucleolar protein Bop1; both proteins direct common pre-rRNA processing steps (maturation of 28S and 5.8S rRNAs); interaction with Bop1 is essential for efficient incorporation of Pes1 into nucleolar preribosomal complexes; Pes1 mutants defective for Bop1 interaction lose the ability to affect rRNA maturation and cell cycle arrest. Transposon-derived dominant mutants, co-immunoprecipitation, rRNA processing assays, cell cycle analysis, sucrose gradient fractionation Molecular cell High 15225545
2005 Pes1 and Bop1 form a stable trimeric complex with a novel WD40 repeat protein, WDR12 (PeBoW complex). Endogenous WDR12 is required for processing of 32S precursor rRNA and cell proliferation. A dominant-negative WDR12 mutant blocks rRNA processing and induces p53 accumulation in a p19ARF-independent manner in proliferating but not quiescent cells. Co-immunoprecipitation, conditional dominant-negative expression, rRNA processing assays, p53/p19ARF genetic analysis The Journal of cell biology High 16043514
2006 Dominant-negative Pes1 deletion mutants (N- and C-terminal truncations) incorporate into the PeBoW complex, block processing of 36S/32S precursors to mature 28S rRNA, inhibit cell proliferation, and induce high p53 levels in proliferating but not resting cells. The dominant-negative effect requires proper incorporation into the PeBoW complex. Deletion mutant expression, co-immunoprecipitation with Bop1/WDR12, nucleolar localization by immunofluorescence, rRNA processing assays, p53 western blot Nucleic acids research High 16738141
2007 Recombinant expression of Pes1, Bop1, and WDR12 is sufficient for PeBoW complex formation. Bop1 is the integral/central component: knockdown of Bop1 abolishes co-purification of Pes1 with WDR12; transport of Bop1 from cytoplasm to nucleolus is Pes1-dependent, while Pes1 migrates to the nucleolus and associates with preribosomal particles independently of Bop1. Overexpression of Bop1 (but not WDR12 or Pes1 alone) inhibits cell proliferation and rRNA processing. Recombinant complex reconstitution, siRNA knockdown, immunofluorescence, cell fractionation, sucrose gradient centrifugation Molecular and cellular biology High 17353269
2006 The BRCT domain of mammalian Pes1 is required for nucleolar localization and rRNA processing. Deletion of the BRCT domain or point mutations of conserved residues cause diffuse nucleoplasmic distribution, failure to rescue rRNA processing in Pes1-knockdown cells, reduced protein stability, and loss of incorporation into the PeBoW complex. siRNA-based knock-down/knock-in system, Pes1 truncation and point mutants, immunofluorescence, rRNA processing assays, co-immunoprecipitation Nucleic acids research High 17189298
2000 Murine Pes1 encodes a nuclear protein containing a BRCT domain; recombinant Pes1 expressed in HepG2 cells localizes to the nucleus. Genomic cloning, sequence analysis, recombinant protein expression, subcellular localization by microscopy Genomics Medium 11112348
2005 In yeast, the Nop7 subcomplex (Nop7/Erb1/Ytm1, orthologs of Pes1/Bop1/WDR12) is present in four consecutive 66S preribosomes; Ytm1 binds directly to Erb1 and is present in a heterotrimeric subcomplex with Erb1 and Nop7 both within and independently of preribosomes; Nop7 and Erb1 assemble into preribosomes prior to Ytm1; mutations in WD40 motifs of Ytm1 disrupt binding to Erb1, destabilize the heterotrimer, and delay pre-rRNA processing and nuclear export. Affinity purification, co-immunoprecipitation, pre-rRNA processing assays, nuclear export assays, WD40 mutant analysis Molecular and cellular biology High 16287855
2008 In yeast, Ytm1, Erb1, and Nop7 (orthologs of WDR12, Bop1, Pes1) assemble into preribosomes interdependently; specific domains within each protein are necessary for interaction and sufficient for preribosome recruitment; dominant-negative truncations of each protein impair growth and ribosome biogenesis. Domain truncation analysis, co-immunoprecipitation, dominant-negative overexpression, ribosome biogenesis assays Molecular biology of the cell High 18448671
2007 Light chain 1 of microtubule-associated protein 1B (Mtap1b-LC1) interacts with the BRCT domain of Pes1; overexpression of Mtap1b-LC1 relocalizes Pes1 from the nucleus/nucleolus to the cytoplasm, reduces nuclear Pes1 levels, and inhibits cell proliferation—phenocopying Pes1 depletion. Yeast two-hybrid screen, co-immunoprecipitation, deletion analysis, immunofluorescence, cell proliferation assay, shRNA knockdown The Journal of biological chemistry High 17308336
2009 Nucleolar protein B23 (nucleophosmin) physically interacts with PES1; knockdown of B23 by RNAi increases nucleoplasmic distribution of PES1, indicating B23 is involved in the nucleolar localization of PES1. Co-immunoprecipitation of endogenous proteins, in vitro pulldown domain mapping, immunofluorescence colocalization, siRNA knockdown Acta biochimica et biophysica Sinica Medium 20011973
2012 PES1 differentially regulates ERα and ERβ: it enhances ERα transcriptional activity while inhibiting ERβ transcriptional activity; increases ERα protein stability and decreases ERβ protein stability via the ubiquitin-proteasome pathway mediated by CHIP (carboxyl terminus of Hsc70-interacting protein); PES1 transforms normal mammary epithelial cells and is required for estrogen-induced breast tumor growth in nude mice. Transcriptional reporter assays, co-immunoprecipitation, ubiquitination assays, proteasome inhibitor experiments, knockdown/overexpression, cell transformation assay, xenograft tumor model The Journal of clinical investigation High 22820289
2016 PES1 is SUMOylated by SUMO-1, SUMO-2, and SUMO-3; the major SUMOylation site is K517 in the C-terminal Glu-rich domain; SUMOylation is stimulated by estrogen; SUMOylation stabilizes PES1 by inhibiting its ubiquitination; SUMOylated PES1 enhances ERα stability and ERα-mediated transcription, increases S-phase fraction, and promotes breast cancer cell proliferation. SUMOylation assays, site-directed mutagenesis (K517R), ubiquitination assays, estrogen treatment, reporter assays, cell cycle analysis, xenograft model Oncotarget High 27409667
2019 PES1 forms a complex with telomerase reverse transcriptase (TERT) and telomerase RNA (TR) through direct interaction with TERT; PES1 facilitates telomerase assembly by promoting direct interaction between TERT and TR without affecting their expression levels; PES1 does not interact with previously reported telomerase components Reptin, Pontin, p23, or Hsp90; depletion of PES1 reduces telomerase activity, leads to telomere shortening, and induces cellular senescence. Co-immunoprecipitation, direct interaction assays, telomerase activity assays (TRAP), telomere length measurement, cellular senescence assays, PES1 knockdown Science advances High 31106266
2012 c-Jun (but not JunB, JunD, c-Fos, or dominant-negative c-Jun) directly activates PES1 promoter transcription; the c-Jun binding sequence was mapped to the -274/-264 region of the PES1 promoter; JNK kinase is upstream of c-Jun in controlling PES1 expression; PES1 silencing in colon cancer cells reduces proliferation and causes G1 arrest. Luciferase reporter assays, chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA), siRNA knockdown, xenograft model PloS one High 22860098
2018 PES1 is transcriptionally regulated by bromodomain-containing protein BRD4; PES1 knockdown decreases glycolysis (altering GLUT1, PKM2, ENO1, FBP1, PCK1 expression) in hepatocellular carcinoma cells; PES1 is partially responsible for the antitumor effect of BET inhibitors. BRD4 knockdown/inhibitor experiments, PES1 knockdown, glycolysis gene expression analysis, BET inhibitor treatment The international journal of biochemistry & cell biology Medium 30172011
2019 PES1 interacts with BRD4 to enhance c-Myc expression; elevated c-Myc is the primary cause of cancer cell resistance to BET inhibitors; CDK5 inhibitors destabilize PES1 and overcome resistance to BET inhibitors in pancreatic cancer cells. Co-immunoprecipitation (PES1-BRD4 interaction), western blotting, CDK5 inhibitor treatment, BET inhibitor resistance assays, xenograft model Journal of experimental & clinical cancer research Medium 31718704
2018 NOP7 (PES1) is a binding partner of β-catenin; NOP7 strengthens interaction between β-catenin and TCF4, leading to activation of β-catenin/TCF signaling in hepatocellular carcinoma cells. Co-immunoprecipitation, β-catenin/TCF reporter assay, cell growth and migration assays OncoTargets and therapy Medium 30319277
2021 SNHG17 (lncRNA) impedes PES1 degradation by inhibiting Trim23-mediated ubiquitination of PES1, thereby stabilizing PES1 protein in colorectal cancer cells. RNA pull-down, RNA immunoprecipitation, co-immunoprecipitation, ubiquitination assays, SNHG17 knockdown/overexpression Journal of experimental & clinical cancer research Medium 34782005
2023 PES1 interacts with ILF3 and interferes with the interaction between ILF3 and IL15 mRNA, impairing ILF3-mediated stabilization of IL15 mRNA and thereby reducing IL15 protein level; this suppresses CD8+ T cell infiltration in esophageal squamous cell carcinoma. Mass spectrometry (interactome), co-immunoprecipitation, proximity ligation assay, RNA immunoprecipitation, IL15 mRNA stability assays, RNA sequencing, PES1 knockdown in vitro and in vivo Journal of biomedical science Medium 36959575
2015 PES1 ablation in colorectal cancer cells increases steady-state and etoposide-induced γ-H2AX levels, delays resolution of γ-H2AX after DNA damage removal, decreases DNA repair capacity by comet assay, and diminishes steady-state and DNA-damage-induced nuclear RAD51 levels, indicating a role for PES1 in the DNA damage response and chemoresistance. PES1 siRNA knockdown, γ-H2AX western blot and immunofluorescence, comet assay, RAD51 nuclear localization by fractionation, drug sensitivity assays, rescue by exogenous PES1 re-expression Biochemical and biophysical research communications Medium 23333390
2015 In neuroblastoma cells, PES1 localizes to the dense fibrillar component of the nucleolus (not the granular component); treatment with the DNA-damaging agent camptothecin causes dramatic redistribution of PES1 to diffuse nucleoplasmic localization. Immunofluorescence with nucleolar compartment markers, camptothecin treatment, confocal microscopy Cancer science Medium 25557119

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nature chemical biology 2384 27842066
2007 Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. American journal of human genetics 195 17236139
2005 Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. The Journal of cell biology 165 16043514
2004 Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Molecular cell 113 15225545
2007 Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Molecular and cellular biology 112 17353269
2005 Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Molecular and cellular biology 84 16287855
2006 Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. Nucleic acids research 76 16738141
2012 PES1 promotes breast cancer by differentially regulating ERα and ERβ. The Journal of clinical investigation 68 22820289
2005 Growth of human cells on polyethersulfone (PES) hollow fiber membranes. Biomaterials 63 15576161
2012 Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions. Chemistry (Weinheim an der Bergstrasse, Germany) 59 22915361
2006 A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus. The FEBS journal 56 16759234
2021 SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop. Journal of experimental & clinical cancer research : CR 51 34782005
2005 Vascularization and gene regulation of human endothelial cells growing on porous polyethersulfone (PES) hollow fiber membranes. Biomaterials 51 15621235
2008 Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes. Molecular biology of the cell 50 18448671
2007 Photografted thin polymer hydrogel layers on PES ultrafiltration membranes: characterization, stability, and influence on separation performance. Langmuir : the ACS journal of surfaces and colloids 50 17547431
2019 PES1 is a critical component of telomerase assembly and regulates cellular senescence. Science advances 40 31106266
2006 The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing. Nucleic acids research 40 17189298
2018 Surface modification of PES membrane via aminolysis and immobilization of carboxymethylcellulose and sulphated carboxymethylcellulose for hemodialysis. Carbohydrate polymers 39 29525169
2020 Effect of Chitosan's Degree of Deacetylation on the Performance of PES Membrane Infused with Chitosan during AMD Treatment. Membranes 38 32213825
2012 Nonribosomal peptide synthetase genes pesL and pes1 are essential for Fumigaclavine C production in Aspergillus fumigatus. Applied and environmental microbiology 38 22344643
2005 Characterization of lipophilic pentasaccharides from beach morning glory (Ipomoea pes-caprae). Journal of natural products 37 15730248
2016 Osteoblast differentiation of mesenchymal stem cells on modified PES-PEG electrospun fibrous composites loaded with Zn2SiO4 bioceramic nanoparticles. Differentiation; research in biological diversity 36 27575952
2019 PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer. Journal of experimental & clinical cancer research : CR 35 31718704
2012 Transcriptional regulation of PES1 expression by c-Jun in colon cancer. PloS one 35 22860098
2018 PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma. The international journal of biochemistry & cell biology 34 30172011
1994 PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors. Development (Cambridge, England) 34 8162851
2021 Effect of carbon nanotubes loading and pressure on the performance of a polyethersulfone (PES)/carbon nanotubes (CNT) membrane. Scientific reports 32 34893653
2017 The effect of nanofibre-based polyethersulfone (PES) scaffold on the chondrogenesis of human induced pluripotent stem cells. Artificial cells, nanomedicine, and biotechnology 31 29103309
2017 Enhanced chondrogenesis of human bone marrow mesenchymal Stem Cell (BMSC) on nanofiber-based polyethersulfone (PES) scaffold. Gene 30 29197591
2016 SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination. Oncotarget 27 27409667
2000 The murine Pes1 gene encodes a nuclear protein containing a BRCT domain. Genomics 27 11112348
2019 PES1 enhances proliferation and tumorigenesis in hepatocellular carcinoma via the PI3K/AKT pathway. Life sciences 24 30630006
2015 Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Cancer science 24 25557119
2014 Long-distance dispersal by sea-drifted seeds has maintained the global distribution of Ipomoea pes-caprae subsp. brasiliensis (Convolvulaceae). PloS one 24 24755614
2013 PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer. IUBMB life 24 24376209
2018 Molecular Cloning and Functional Characterization of the Dehydrin (IpDHN) Gene From Ipomoea pes-caprae. Frontiers in plant science 23 30364314
2006 Degradation of polyethylene succinate (PES) by a new thermophilic Microbispora strain. Biodegradation 23 17109189
2019 Isolation and characterization of an atypical LEA gene (IpLEA) from Ipomoea pes-caprae conferring salt/drought and oxidative stress tolerance. Scientific reports 22 31619699
2019 PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERα/ERβ protein ratio. Scientific reports 21 30705367
2007 Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature. The Knee 21 17669658
2017 Iron-tannin-framework complex modified PES ultrafiltration membranes with enhanced filtration performance and fouling resistance. Journal of colloid and interface science 20 28651204
2017 Influence of Frozen Residues on the Exploration of the PES of Enzyme Reaction Mechanisms. Journal of chemical theory and computation 20 28992703
2016 Biofouling prevention using silver nanoparticle impregnated polyethersulfone (PES) membrane: E. coli cell-killing in a continuous cross-flow membrane module. Journal of colloid and interface science 20 28011400
2015 Stepwise catalytic mechanism via short-lived intermediate inferred from combined QM/MM MERP and PES calculations on retaining glycosyltransferase ppGalNAcT2. PLoS computational biology 20 25849117
2020 PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain. The Journal of biological chemistry 19 33835030
2018 Functional Identification of Salt-Stress-Related Genes Using the FOX Hunting System from Ipomoea pes-caprae. International journal of molecular sciences 19 30400210
2007 Distribution of flower morphs, ploidy level and sexual reproduction of the invasive weed Oxalis pes-caprae in the western area of the Mediterranean region. Annals of botany 19 17218342
2023 Phytochemical profile and antioxidant capacity, α-amylase and α-glucosidase inhibitory activities of Oxalis pes-caprae extracts in alloxan-induced diabetic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 18 36774725
2014 Proteomic analysis of the extracellular matrix in idiopathic pes equinovarus. Molecular and cellular biochemistry 18 25472880
2022 Topical gel containing phenolic-rich extract from Ipomoea pes-capre leaf (Convolvulaceae) has anti-inflammatory, wound healing, and antiophidic properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 17 36068780
2020 RNA-seq reveals the salt tolerance of Ipomoea pes-caprae, a wild relative of sweet potato. Journal of plant physiology 17 33059125
2011 Pentasaccharide resin glycosides from Ipomoea pes-caprae. Journal of natural products 17 21338052
2015 Repression of PES1 expression inhibits growth of gastric cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 16 26423399
1996 The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein. Seminars in cancer biology 16 8740563
2023 Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs. Free radical biology & medicine 15 37678654
2020 Characterization of a phytochelatin synthase gene from Ipomoea pes-caprae involved in cadmium tolerance and accumulation in yeast and plants. Plant physiology and biochemistry : PPB 15 32866789
2009 B23 interacts with PES1 and is involved in nucleolar localization of PES1. Acta biochimica et biophysica Sinica 15 20011973
1995 The pathology of the lower leg muscles in pure forefoot pes cavus. Acta neuropathologica 15 7676811
2008 Resin glycoside constituents of Ipomoea pes-caprae (beach morning glory). Journal of natural products 14 19061389
2007 Postnatal bone elongation of the manus versus pes: analysis of the chondrocytic differentiation cascade in Mus musculus and Eptesicus fuscus. Cells, tissues, organs 14 18160802
2019 PES1 is regulated by CD44 in liver cancer stem cells via miR-105-5p. FEBS letters 13 31127852
2013 PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs. Biochemical and biophysical research communications 13 23333390
2004 Muscles of the pes of hylid frogs. Journal of morphology 13 15108161
2023 PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma. Journal of biomedical science 12 36959575
2016 PES Surface Modification Using Green Chemistry: New Generation of Antifouling Membranes. Membranes 12 27096873
2019 Ipomeolides A and B, Resin Glycosides from Ipomoea pes-caprae and Combination Therapy of Ipomeolide A with Doxorubicin. Journal of natural products 11 31017778
2017 Ipomoea pes-caprae (L.) R. Br (Convolvulaceae) relieved nociception and inflammation in mice - A topical herbal medicine against effects due to cnidarian venom-skin contact. Journal of ethnopharmacology 11 28196712
2012 Enzyme-catalyzed modification of PES surfaces: reduction in adsorption of BSA, dextrin and tannin. Journal of colloid and interface science 11 22560487
2022 Skin Anti-Aging Potential of Ipomoea pes-caprae Ethanolic Extracts on Promoting Cell Proliferation and Collagen Production in Human Fibroblasts (CCD-986sk Cells). Pharmaceuticals (Basel, Switzerland) 10 36015117
2014 2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53. Biochemical pharmacology 10 25139326
1989 Inhibitory effect of extract of Ipomoea pes-caprae on guinea-pig ileal smooth muscle. Acta pharmaceutica Nordica 10 2597337
2023 Uncovering the effective substances and mechanism of Ipomoea pes-caprae against rheumatoid arthritis using liquid chromatography-mass spectrometry and targeted network pharmacology. Journal of separation science 9 36772844
2023 PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment. Cancer medicine 9 37076985
2022 In Situ Generation of Fouling Resistant Ag/Pd Modified PES Membranes for Treatment of Pharmaceutical Wastewater. Membranes 9 36005677
2021 Giant Vesicles Produced with Phosphatidylcholines (PCs) and Phosphatidylethanolamines (PEs) by Water-in-Oil Inverted Emulsions. Life (Basel, Switzerland) 9 33801936
2020 microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ. Journal of translational medicine 9 32448371
2011 Giant cell tumor of the pes anserine bursa (extra-articular pigmented villonodular bursitis): a case report and review of the literature. Case reports in medicine 9 21687595
2009 Congenital pes cavus in a Charcot-Marie-tooth disease type 1A newborn. Pediatric neurology 9 19433282
2000 Biodegradable poly(ethylene succinate) (PES). 2. Crystal morphology of melt-crystallized ultrathin film and its change after enzymatic degradation. Biomacromolecules 9 11710202
1999 Conservative management of posterior tibial tendon dysfunction, subtalar joint complex, and pes planus deformity. Clinics in podiatric medicine and surgery 9 10470507
1999 Complexity of developmental control: analysis of embryonic cell lineage specification in Caenorhabditis elegans using pes-1 as an early marker. Genetics 9 9872954
2023 SCARECROW-like GRAS protein PES positively regulates petunia floral scent production. Plant physiology 8 36760164
2022 The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells. International journal of molecular sciences 8 36361992
2021 How to manage pes cavus in children and adolescents? EFORT open reviews 8 34267941
2016 Mechanism of Alcohol-Water Dehydrogenative Coupling into Carboxylic Acid Using Milstein's Catalyst: A Detailed Investigation of the Outer-Sphere PES in the Reaction of Aldehydes with an Octahedral Ruthenium Hydroxide. Inorganic chemistry 8 27467132
2007 Light chain 1 of microtubule-associated protein 1B can negatively regulate the action of Pes1. The Journal of biological chemistry 8 17308336
2024 Immobilization of carbonic anhydrase on modified PES membranes for artificial lungs. Journal of materials chemistry. B 7 38345129
2023 Novel Insights from Clinical Practice: Xia-Gibbs Syndrome with Pes Cavus, Conjunctival Melanosis, and Eye Asymmetry due to a de novo AHDC1 Gene Variant - A Case Report and a Brief Review of the Literature. Molecular syndromology 7 38357260
2021 Licochalcone A inhibits cell growth through the downregulation of the Hippo pathway via PES1 in cholangiocarcinoma cells. Environmental toxicology 7 34845814
2019 Formulation and evaluation of letrozole-loaded spray dried liposomes with PEs for topical application. Journal of liposome research 7 31223043
2018 NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells. OncoTargets and therapy 7 30319277
2008 The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial. BMC musculoskeletal disorders 7 18241355
2005 Improved protein-adsorption-resistant property of PES/SPC blend membrane by adjustment of coagulation bath composition. Colloids and surfaces. B, Biointerfaces 7 16343865
2024 Emerging role of PES1 in disease: A promising therapeutic target? Gene 6 39209183
2022 Phytochemistry, biological activities and in silico molecular docking studies of Oxalis pes-caprae L. compounds against SARS-CoV-2. Journal of King Saud University. Science 6 35756195
2022 A high-protein retained PES hemodialysis membrane with tannic acid as a multifunctional modifier. Colloids and surfaces. B, Biointerfaces 6 36252532
2020 Probing protein rejection behavior of blended PES-based flat-sheet ultrafiltration membranes: A density functional theory (DFT) study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 6 32388231
1989 The developmental anatomy of pes valgo planus. Clinics in podiatric medicine and surgery 6 2665922
2024 Targeting host inducible-heat shock protein 70 with PES-Cl is a promising antiviral strategy against SARS-CoV-2 infection and pathogenesis. International journal of biological macromolecules 5 39187102
2021 In Leishmania major, the Homolog of the Oncogene PES1 May Play a Critical Role in Parasite Infectivity. International journal of molecular sciences 5 34830469

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