Affinage

PES1

Pescadillo homolog · UniProt O00541

Round 2 corrected
Length
588 aa
Mass
68.0 kDa
Annotated
2026-04-29
130 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PES1 (Pescadillo) is a nucleolar protein essential for large ribosomal subunit biogenesis and with expanding roles in telomere maintenance, estrogen receptor signaling, and immune evasion. It assembles with Bop1 and WDR12 into the PeBoW complex, which is required for processing of 32S/36S precursor rRNA into mature 28S and 5.8S rRNA; its BRCT domain is indispensable for nucleolar localization, PeBoW incorporation, and rRNA processing function, and disruption of the complex triggers p53 accumulation and cell cycle arrest (PMID:15225545, PMID:16043514, PMID:17189298). Beyond ribosome biogenesis, PES1 directly interacts with TERT to promote telomerase RNA–TERT assembly and telomerase activity (PMID:31106266), differentially stabilizes ERα while destabilizing ERβ through CHIP-mediated ubiquitination—a process counteracted by SUMO-1/2/3 modification at K517 (PMID:22820289, PMID:27409667)—and suppresses CD8⁺ T cell–mediated immune surveillance by disrupting the ILF3–IL15 mRNA stabilization complex (PMID:36959575). PES1 protein stability is itself regulated by Trim23-mediated ubiquitination, which is inhibited by the lncRNA SNHG17 (PMID:34782005).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2000 Medium

    Identification of PES1 as a BRCT-domain-containing nuclear protein established a candidate link between a domain found in DNA repair/checkpoint factors and a novel nucleolar function.

    Evidence Recombinant expression in HepG2 cells with microscopy and sequence analysis

    PMID:11112348

    Open questions at the time
    • No functional assay performed; localization was by overexpression only
    • BRCT domain function not tested
  2. 2005 High

    Discovery that PES1, Bop1, and WDR12 form the trimeric PeBoW complex required for 28S/5.8S rRNA maturation resolved how PES1 participates in 60S ribosomal subunit biogenesis and explained why dominant-negative PES1 mutants trigger p53-dependent cell cycle arrest.

    Evidence Co-immunoprecipitation, pre-rRNA processing assays, dominant-negative mutant panels, sucrose gradient sedimentation in mammalian cells; corroborated by yeast Ytm1/Erb1/Nop7 heterotrimer studies

    PMID:15225545 PMID:16043514 PMID:16287855

    Open questions at the time
    • Structural basis of PeBoW assembly unknown at atomic resolution
    • Mechanism by which PeBoW disruption activates p53 without p19ARF involvement not fully resolved
  3. 2006 High

    Demonstration that the BRCT domain is essential for nucleolar localization, PeBoW incorporation, and rRNA processing function identified the key structural determinant of PES1 activity and explained how Bop1-dependent nucleolar import is organized.

    Evidence Conditional siRNA knock-down/knock-in with BRCT deletion and point mutants; recombinant co-expression of three subunits; subcellular fractionation

    PMID:17189298 PMID:17353269

    Open questions at the time
    • BRCT domain binding partner within the pre-ribosome not identified
    • Whether BRCT mediates RNA or protein contacts in the nucleolus remains unclear
  4. 2007 High

    Identification of MAP1B-LC1 as a BRCT-domain-binding partner that sequesters PES1 in the cytoplasm revealed a mechanism for cytoplasmic retention and proliferation control independent of PeBoW disruption.

    Evidence Yeast two-hybrid confirmed by co-immunoprecipitation, deletion mapping, and cell proliferation assays

    PMID:17308336

    Open questions at the time
    • Physiological context in which MAP1B-LC1 regulates PES1 localization not defined
    • Whether this interaction modulates rRNA processing in vivo untested
  5. 2012 High

    Discovery that PES1 differentially regulates ERα and ERβ stability through CHIP-mediated ubiquitination established a non-ribosomal oncogenic function for PES1 in breast cancer.

    Evidence Co-immunoprecipitation, ubiquitination assays, luciferase reporters, soft-agar transformation, and xenograft model

    PMID:22820289

    Open questions at the time
    • Structural basis of differential ERα stabilization versus ERβ destabilization not resolved
    • Whether this function is independent of PES1's ribosome biogenesis role not determined
  6. 2016 High

    Identification of K517 as a SUMO-1/2/3 modification site that stabilizes PES1 by inhibiting ubiquitination provided a post-translational mechanism governing PES1 protein levels and its ERα-promoting activity.

    Evidence Site-directed mutagenesis (K517R), SUMO/ubiquitination assays, luciferase reporters, xenograft model

    PMID:27409667

    Open questions at the time
    • E3 SUMO ligase responsible not identified
    • Interplay between K517 SUMOylation and Trim23-mediated ubiquitination not examined
  7. 2019 High

    Demonstration that PES1 directly binds TERT and promotes TERT–TR assembly uncovered a telomere maintenance function distinct from ribosome biogenesis and independent of known telomerase assembly chaperones.

    Evidence Reciprocal co-immunoprecipitation, TRAP telomerase activity assay, telomere length measurement, senescence assays

    PMID:31106266

    Open questions at the time
    • Binding interface between PES1 and TERT not mapped
    • Whether PES1's telomerase role is nucleolar or nucleoplasmic is unclear
  8. 2019 Medium

    Discovery that PES1 interacts with BRD4 and enhances c-Myc expression linked PES1 to BET-regulated transcriptional programs and provided a mechanism for BET inhibitor resistance in pancreatic cancer.

    Evidence Co-immunoprecipitation, CDK5 inhibitor destabilization of PES1, colony formation, xenograft model

    PMID:31718704

    Open questions at the time
    • Whether PES1–BRD4 interaction is direct or bridged by other factors not resolved
    • Mechanism by which CDK5 stabilizes PES1 protein not defined
  9. 2021 Medium

    Identification of Trim23 as an E3 ubiquitin ligase for PES1, with the lncRNA SNHG17 blocking this degradation, revealed a post-translational regulatory axis controlling PES1 abundance in colorectal cancer.

    Evidence RNA pulldown, RIP, co-immunoprecipitation, ubiquitination assays, xenograft and metastasis models

    PMID:34782005

    Open questions at the time
    • Ubiquitination site(s) on PES1 targeted by Trim23 not mapped
    • Relationship between Trim23-mediated and CHIP-mediated ubiquitination not examined
  10. 2023 High

    Demonstration that PES1 disrupts ILF3-mediated IL15 mRNA stabilization to suppress CD8⁺ T cell infiltration established an immune evasion function for PES1 and explained immunotherapy resistance in esophageal squamous cell carcinoma.

    Evidence Mass spectrometry, co-immunoprecipitation, proximity ligation assay, RNA immunoprecipitation, mouse xenograft model

    PMID:36959575

    Open questions at the time
    • Whether PES1–ILF3 interaction occurs in the nucleolus or nucleoplasm not determined
    • Generalizability of the immune evasion function beyond esophageal cancer untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic-resolution structure of the PeBoW complex, how PES1 partitions between its ribosome biogenesis, telomerase assembly, ER signaling, and immune evasion functions, and whether these roles are interdependent or fully separable.
  • No high-resolution structure of PeBoW or PES1 available
  • Functional separation of ribosomal versus extra-ribosomal roles not demonstrated with separation-of-function mutants
  • Comprehensive interactome under endogenous expression levels lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 5 GO:0060090 molecular adaptor activity 4 GO:0003723 RNA binding 1
Localization
GO:0005730 nucleolus 6 GO:0005634 nucleus 3
Pathway
R-HSA-8953854 Metabolism of RNA 7 R-HSA-1640170 Cell Cycle 3 R-HSA-1643685 Disease 3 R-HSA-392499 Metabolism of proteins 3
Partners
BOP1BRD4CHIPILF3MAP1BTERTTRIM23WDR12
Complex memberships
PeBoW complex (PES1-Bop1-WDR12)TERT-TR-PES1 telomerase assembly complex

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 The murine Pes1 protein contains a BRCT (BRCA1 C-terminal) domain and localizes to the nucleus when expressed recombinantly in HepG2 cells, establishing it as a nuclear protein with a domain typically found in cell-cycle checkpoint and DNA repair factors. Recombinant protein expression, nuclear localization by microscopy, sequence analysis Genomics Medium 11112348
2004 Pes1 physically interacts with the nucleolar protein Bop1; this interaction is essential for the efficient incorporation of Pes1 into nucleolar preribosomal complexes, and both proteins direct common pre-rRNA processing steps (28S and 5.8S rRNA maturation). Pes1 mutants defective in Bop1 binding lose the ability to affect rRNA maturation and arrest the cell cycle. Co-immunoprecipitation, dominant-negative transposon-derived mutants, pre-rRNA processing analysis, cell cycle assays Molecular cell High 15225545
2005 Pes1 and Bop1 form a stable trimeric complex with the novel WD40 repeat protein WDR12 (the PeBoW complex). Endogenous WDR12 is required for processing of 32S precursor rRNA and cell proliferation; a dominant-negative WDR12 mutant blocks rRNA processing and induces reversible cell cycle arrest, accumulating p53 in a p19ARF-independent manner in proliferating but not quiescent cells. Co-immunoprecipitation, conditional dominant-negative expression, rRNA processing assays, p53 accumulation assays The Journal of cell biology High 16043514
2005 In yeast, the Pes1 orthologs Ytm1, Nop7, and Erb1 form a heterotrimeric subcomplex within 66S preribosomes. Ytm1 binds directly to Erb1; mutations in Ytm1 WD40 motifs disrupt Erb1 binding, destabilize the heterotrimer, and delay pre-rRNA processing and nuclear export of preribosomes. Genetic analysis, co-immunoprecipitation, sucrose gradient fractionation, mutant analysis of WD40 motifs Molecular and cellular biology High 16287855
2006 Dominant-negative Pes1 mutants with N- or C-terminal truncations (M1 and M5) co-immunoprecipitate Bop1 and WDR12, incorporate into large preribosomal complexes, block 36S/32S to 28S rRNA processing, inhibit cell proliferation, and induce p53 accumulation in proliferating but not resting cells, confirming that the dominant-negative effect is mediated through the intact PeBoW complex. Co-immunoprecipitation, sucrose gradient sedimentation, rRNA processing analysis, flow cytometry, p53 Western blot Nucleic acids research High 16738141
2006 The BRCT domain of Pes1 is essential for nucleolar localization and rRNA processing function. Deletion of the BRCT domain or point mutations of conserved residues cause diffuse nucleoplasmic distribution of Pes1, failure to replace endogenous Pes1 in rRNA processing, reduced protein stability, and failure to incorporate into the PeBoW complex. Conditional siRNA knock-down/knock-in system, panel of truncation mutants, immunofluorescence, rRNA processing assays Nucleic acids research High 17189298
2007 Assembly and stability of the PeBoW complex require Bop1 as the integral central component: recombinant co-expression of all three subunits (Pes1, Bop1, WDR12) is sufficient for complex formation; Bop1 knockdown abolishes co-purification of Pes1 with WDR12; Bop1 transport from cytoplasm to nucleolus is Pes1-dependent, while Pes1 can migrate to the nucleolus and bind preribosomal particles independently of Bop1. Recombinant co-expression, co-immunoprecipitation, siRNA knockdown, indirect immunofluorescence, cell fractionation, sucrose gradient centrifugation Molecular and cellular biology High 17353269
2007 Light chain 1 of microtubule-associated protein 1B (Mtap1b-LC1) interacts with Pes1 specifically through the Pes1 BRCT domain (identified by yeast two-hybrid and confirmed by co-immunoprecipitation). Overexpression of Mtap1b-LC1 redistributes Pes1 from the nucleus/nucleolus to the cytoplasm and reduces nuclear Pes1, resulting in diminished cell proliferation, mimicking the effect of Pes1 depletion by shRNA. Yeast two-hybrid, co-immunoprecipitation, deletion analysis, protein localization studies, cell proliferation assays, shRNA The Journal of biological chemistry High 17308336
2008 In yeast, Ytm1, Erb1, and Nop7 (orthologs of WDR12, Bop1, Pes1) assemble into preribosomes in an interdependent manner. Specific domains within each protein mediate pairwise interactions and are sufficient for recruitment into preribosomes; dominant-negative truncations of each reveal distinct interaction and functional domains. Genetic epistasis, truncation mutagenesis, co-immunoprecipitation, dominant-negative growth assays Molecular biology of the cell High 18448671
2009 The nucleolar marker protein B23 (nucleophosmin) physically interacts with PES1 in vivo (confirmed by co-immunoprecipitation of endogenous proteins) and in vitro (pulldown assay with mapped interaction domains). Knockdown of B23 by RNAi increases the nucleoplasmic distribution of PES1, indicating that B23 is involved in nucleolar localization of PES1. Co-immunoprecipitation of endogenous proteins, in vitro pulldown, RNAi knockdown, immunofluorescence co-localization Acta biochimica et biophysica Sinica Medium 20011973
2012 PES1 differentially regulates ERα and ERβ protein stability in breast cancer: PES1 enhances ERα transcriptional activity and increases ERα protein stability while inhibiting ERβ transcriptional activity and decreasing ERβ protein stability through the ubiquitin-proteasome pathway mediated by the co-chaperone CHIP. PES1 also transforms normal human mammary epithelial cells and is required for estrogen-induced breast tumor growth in nude mice. Co-immunoprecipitation, ubiquitination assays, luciferase reporter assays, siRNA knockdown, soft-agar transformation assay, xenograft mouse model The Journal of clinical investigation High 22820289
2012 c-Jun transcriptionally activates PES1 expression in colon cancer by directly binding to the -274/-264 region of the PES1 promoter; JNK signaling is upstream of c-Jun in controlling PES1 levels. This was validated by chromatin immunoprecipitation and EMSA. Luciferase reporter assays, chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA), promoter deletion analysis, siRNA knockdown PloS one High 22860098
2013 PES1 regulates DNA damage response in colorectal cancer cells: PES1-silenced cells exhibit elevated steady-state and etoposide-induced γ-H2AX, prolonged persistence of DNA damage, decreased DNA repair by comet assay, increased sensitivity to chemotherapeutic agents, and diminished levels of nuclear RAD51 both basally and after DNA damage. siRNA knockdown, γ-H2AX Western blot, comet assay, drug sensitivity assays, RAD51 immunofluorescence Biochemical and biophysical research communications Medium 23333390
2016 PES1 is SUMOylated at lysine K517 in its C-terminal Glu-rich domain by SUMO-1, -2, and -3, with SUMOylation stimulated by estrogen. SUMOylation stabilizes PES1 by inhibiting its ubiquitination, enhances PES1-mediated promotion of ERα transcriptional activity and ERα stability, and increases the proportion of S-phase cells, promoting breast cancer cell proliferation in vitro and in vivo. SUMO modification assays, site-directed mutagenesis (K517R), ubiquitination assays, luciferase reporter assays, cell cycle analysis, xenograft mouse model Oncotarget High 27409667
2018 PES1 is transcriptionally regulated by BRD4 in hepatocellular carcinoma and promotes glycolysis by altering expression of metabolic genes (GLUT1, PKM2, ENO1, FBP1, PCK1). PES1 knockdown decreased glycolytic activity and partially mediated the antitumor effects of BET inhibitors. BRD4 ChIP, siRNA knockdown, RT-qPCR for metabolic genes, glucose uptake and lactate production assays, xenograft model The international journal of biochemistry & cell biology Medium 30172011
2019 PES1 forms a complex with TERT and telomerase RNA (TR) through direct interaction with TERT, facilitating telomerase assembly by promoting TERT-TR interaction without affecting their individual protein or RNA levels. PES1 does not interact with previously reported telomerase assembly factors Reptin, Pontin, p23, or Hsp90. PES1 knockdown reduces telomerase activity, shortens telomere length, and induces cellular senescence. Co-immunoprecipitation, telomerase activity assays (TRAP), telomere length measurement, senescence assays (SA-β-galactosidase), siRNA knockdown Science advances High 31106266
2019 PES1 interacts with BRD4 to enhance c-Myc expression, contributing to resistance to BET inhibitors in pancreatic cancer. CDK5 inhibitors destabilize PES1 protein and overcome BET inhibitor resistance. Co-immunoprecipitation, Western blot, CDK5 inhibitor treatment, colony formation assay, xenograft model Journal of experimental & clinical cancer research Medium 31718704
2019 PES1 promotes hepatocellular carcinoma cell proliferation and tumorigenicity through activation of the PI3K/AKT/GSK3β/cyclin D1 signaling pathway, as demonstrated by PES1 knockdown reducing phosphorylated AKT and GSK3β and decreasing cyclin D1 expression. siRNA knockdown, Western blot for pathway components, CCK-8 proliferation assay, xenograft mouse model Life sciences Low 30630006
2019 PES1 is regulated by CD44 in liver cancer stem cells via miR-105-5p: CD44 suppresses miR-105-5p expression, and miR-105-5p directly targets and negatively regulates PES1 mRNA, promoting cell proliferation. Luciferase reporter assay (miR-105-5p binding to PES1 3'UTR), RT-qPCR, Western blot, siRNA/miRNA overexpression FEBS letters Medium 31127852
2019 PES1 promotes papillary thyroid cancer by upregulating the ERα/ERβ protein ratio, increasing ERα protein levels while reducing ERβ protein levels, promoting proliferation, invasion, and migration of thyroid cancer cells. siRNA knockdown, Western blot, proliferation/invasion/migration assays (Transwell), immunohistochemistry of clinical samples Scientific reports Medium 30705367
2021 SNHG17 (lncRNA) impedes PES1 protein degradation by inhibiting Trim23-mediated ubiquitination of PES1, thereby stabilizing PES1 protein and promoting colorectal cancer proliferation and metastasis. RNA pulldown, RNA immunoprecipitation, co-immunoprecipitation, ubiquitination assays, xenograft and metastasis models Journal of experimental & clinical cancer research Medium 34782005
2023 PES1 suppresses CD8+ T cell infiltration and immunotherapy sensitivity in esophageal squamous cell carcinoma by interfering with the ILF3-IL15 mRNA axis: PES1 associates with ILF3 (identified by mass spectrometry and co-immunoprecipitation) and disrupts the interaction between ILF3 and IL15 mRNA, impairing ILF3-mediated stabilization of IL15 mRNA and reducing IL15 protein levels. RNA sequencing, mass spectrometry, co-immunoprecipitation, proximity ligation assay, RNA immunoprecipitation, siRNA knockdown, mouse xenograft model Journal of biomedical science High 36959575

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nature chemical biology 2319 27842066
1998 Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 2060 9630216
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1992 Human cyclooxygenase-2 cDNA. Proceedings of the National Academy of Sciences of the United States of America 1379 1380156
2002 COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proceedings of the National Academy of Sciences of the United States of America 1262 12242329
1994 The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature 996 8121489
1994 Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proceedings of the National Academy of Sciences of the United States of America 917 7510883
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
1993 Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS letters 698 8365485
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1991 Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 505 1907252
1995 Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. The Journal of biological chemistry 449 7559624
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
1994 Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2. European journal of biochemistry 354 8181472
1989 Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochemical and biophysical research communications 315 2512924
2003 Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. The Journal of biological chemistry 290 12835322
2000 The productive conformation of arachidonic acid bound to prostaglandin synthase. Science (New York, N.Y.) 240 10988074
2003 Genetic variation in cyclooxygenase 1: effects on response to aspirin. Clinical pharmacology and therapeutics 209 12545150
2001 Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry 204 11318639
2008 Cyclooxygenase in normal human tissues--is COX-1 really a constitutive isoform, and COX-2 an inducible isoform? Journal of cellular and molecular medicine 192 18657230
2007 Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. American journal of human genetics 192 17236139
2003 Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. Cancer 191 12784332
1993 N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum. The Journal of biological chemistry 180 8349699
2005 Cyclooxygenase-1 haplotype modulates platelet response to aspirin. Journal of thrombosis and haemostasis : JTH 174 16150050
2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. American journal of human genetics 164 19913121
2005 Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. The Journal of cell biology 164 16043514
2002 Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. Cancer research 156 11809691
2008 Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Journal of proteome research 148 18570454
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
2004 Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Molecular cell 113 15225545
2007 Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Molecular and cellular biology 112 17353269
1997 Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. The American journal of physiology 110 9435560
2001 Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. The Journal of biological chemistry 106 11477109
2005 Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Molecular and cellular biology 84 16287855
2006 Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. Nucleic acids research 76 16738141
2012 PES1 promotes breast cancer by differentially regulating ERα and ERβ. The Journal of clinical investigation 68 22820289
2005 Growth of human cells on polyethersulfone (PES) hollow fiber membranes. Biomaterials 63 15576161
2012 Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions. Chemistry (Weinheim an der Bergstrasse, Germany) 59 22915361
2006 A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus. The FEBS journal 56 16759234
2005 Vascularization and gene regulation of human endothelial cells growing on porous polyethersulfone (PES) hollow fiber membranes. Biomaterials 51 15621235
2021 SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop. Journal of experimental & clinical cancer research : CR 50 34782005
2008 Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes. Molecular biology of the cell 50 18448671
2007 Photografted thin polymer hydrogel layers on PES ultrafiltration membranes: characterization, stability, and influence on separation performance. Langmuir : the ACS journal of surfaces and colloids 50 17547431
2019 PES1 is a critical component of telomerase assembly and regulates cellular senescence. Science advances 40 31106266
2006 The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing. Nucleic acids research 40 17189298
2018 Surface modification of PES membrane via aminolysis and immobilization of carboxymethylcellulose and sulphated carboxymethylcellulose for hemodialysis. Carbohydrate polymers 39 29525169
2020 Effect of Chitosan's Degree of Deacetylation on the Performance of PES Membrane Infused with Chitosan during AMD Treatment. Membranes 38 32213825
2012 Nonribosomal peptide synthetase genes pesL and pes1 are essential for Fumigaclavine C production in Aspergillus fumigatus. Applied and environmental microbiology 38 22344643
2005 Characterization of lipophilic pentasaccharides from beach morning glory (Ipomoea pes-caprae). Journal of natural products 36 15730248
2019 PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer. Journal of experimental & clinical cancer research : CR 35 31718704
2016 Osteoblast differentiation of mesenchymal stem cells on modified PES-PEG electrospun fibrous composites loaded with Zn2SiO4 bioceramic nanoparticles. Differentiation; research in biological diversity 35 27575952
2012 Transcriptional regulation of PES1 expression by c-Jun in colon cancer. PloS one 35 22860098
2018 PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma. The international journal of biochemistry & cell biology 34 30172011
1994 PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors. Development (Cambridge, England) 34 8162851
2016 Functional characterization of the ribosome biogenesis factors PES, BOP1, and WDR12 (PeBoW), and mechanisms of defective cell growth and proliferation caused by PeBoW deficiency in Arabidopsis. Journal of experimental botany 31 27440937
2017 The effect of nanofibre-based polyethersulfone (PES) scaffold on the chondrogenesis of human induced pluripotent stem cells. Artificial cells, nanomedicine, and biotechnology 30 29103309
2017 Enhanced chondrogenesis of human bone marrow mesenchymal Stem Cell (BMSC) on nanofiber-based polyethersulfone (PES) scaffold. Gene 30 29197591
2021 Effect of carbon nanotubes loading and pressure on the performance of a polyethersulfone (PES)/carbon nanotubes (CNT) membrane. Scientific reports 28 34893653
2016 SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination. Oncotarget 27 27409667
2000 The murine Pes1 gene encodes a nuclear protein containing a BRCT domain. Genomics 27 11112348
2019 PES1 enhances proliferation and tumorigenesis in hepatocellular carcinoma via the PI3K/AKT pathway. Life sciences 24 30630006
2014 Long-distance dispersal by sea-drifted seeds has maintained the global distribution of Ipomoea pes-caprae subsp. brasiliensis (Convolvulaceae). PloS one 24 24755614
2013 PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer. IUBMB life 24 24376209
2018 Molecular Cloning and Functional Characterization of the Dehydrin (IpDHN) Gene From Ipomoea pes-caprae. Frontiers in plant science 23 30364314
2015 Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Cancer science 23 25557119
2006 Degradation of polyethylene succinate (PES) by a new thermophilic Microbispora strain. Biodegradation 23 17109189
2019 Isolation and characterization of an atypical LEA gene (IpLEA) from Ipomoea pes-caprae conferring salt/drought and oxidative stress tolerance. Scientific reports 22 31619699
2007 Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature. The Knee 21 17669658
2019 PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERα/ERβ protein ratio. Scientific reports 20 30705367
2017 Iron-tannin-framework complex modified PES ultrafiltration membranes with enhanced filtration performance and fouling resistance. Journal of colloid and interface science 20 28651204
2017 Influence of Frozen Residues on the Exploration of the PES of Enzyme Reaction Mechanisms. Journal of chemical theory and computation 20 28992703
2016 Biofouling prevention using silver nanoparticle impregnated polyethersulfone (PES) membrane: E. coli cell-killing in a continuous cross-flow membrane module. Journal of colloid and interface science 20 28011400
2015 Stepwise catalytic mechanism via short-lived intermediate inferred from combined QM/MM MERP and PES calculations on retaining glycosyltransferase ppGalNAcT2. PLoS computational biology 20 25849117
2020 PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain. The Journal of biological chemistry 19 33835030
2018 Functional Identification of Salt-Stress-Related Genes Using the FOX Hunting System from Ipomoea pes-caprae. International journal of molecular sciences 19 30400210
2007 Distribution of flower morphs, ploidy level and sexual reproduction of the invasive weed Oxalis pes-caprae in the western area of the Mediterranean region. Annals of botany 19 17218342
2022 Topical gel containing phenolic-rich extract from Ipomoea pes-capre leaf (Convolvulaceae) has anti-inflammatory, wound healing, and antiophidic properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 17 36068780
2020 RNA-seq reveals the salt tolerance of Ipomoea pes-caprae, a wild relative of sweet potato. Journal of plant physiology 17 33059125
2014 Proteomic analysis of the extracellular matrix in idiopathic pes equinovarus. Molecular and cellular biochemistry 17 25472880
2011 Pentasaccharide resin glycosides from Ipomoea pes-caprae. Journal of natural products 17 21338052
2023 Phytochemical profile and antioxidant capacity, α-amylase and α-glucosidase inhibitory activities of Oxalis pes-caprae extracts in alloxan-induced diabetic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 16 36774725
2015 Repression of PES1 expression inhibits growth of gastric cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 16 26423399
1996 The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein. Seminars in cancer biology 16 8740563
2020 Characterization of a phytochelatin synthase gene from Ipomoea pes-caprae involved in cadmium tolerance and accumulation in yeast and plants. Plant physiology and biochemistry : PPB 15 32866789
2009 B23 interacts with PES1 and is involved in nucleolar localization of PES1. Acta biochimica et biophysica Sinica 15 20011973
2023 Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs. Free radical biology & medicine 14 37678654
2008 Resin glycoside constituents of Ipomoea pes-caprae (beach morning glory). Journal of natural products 14 19061389
2007 Postnatal bone elongation of the manus versus pes: analysis of the chondrocytic differentiation cascade in Mus musculus and Eptesicus fuscus. Cells, tissues, organs 14 18160802
1995 The pathology of the lower leg muscles in pure forefoot pes cavus. Acta neuropathologica 14 7676811
2019 PES1 is regulated by CD44 in liver cancer stem cells via miR-105-5p. FEBS letters 13 31127852
2013 PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs. Biochemical and biophysical research communications 13 23333390
2004 Muscles of the pes of hylid frogs. Journal of morphology 13 15108161
2016 PES Surface Modification Using Green Chemistry: New Generation of Antifouling Membranes. Membranes 12 27096873
2019 Ipomeolides A and B, Resin Glycosides from Ipomoea pes-caprae and Combination Therapy of Ipomeolide A with Doxorubicin. Journal of natural products 11 31017778
2018 Ipomoea pes-caprae IpASR Improves Salinity and Drought Tolerance in Transgenic Escherichia coli and Arabidopsis. International journal of molecular sciences 11 30071625
2017 Ipomoea pes-caprae (L.) R. Br (Convolvulaceae) relieved nociception and inflammation in mice - A topical herbal medicine against effects due to cnidarian venom-skin contact. Journal of ethnopharmacology 11 28196712
2023 PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma. Journal of biomedical science 10 36959575
2022 Skin Anti-Aging Potential of Ipomoea pes-caprae Ethanolic Extracts on Promoting Cell Proliferation and Collagen Production in Human Fibroblasts (CCD-986sk Cells). Pharmaceuticals (Basel, Switzerland) 10 36015117
2014 2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53. Biochemical pharmacology 10 25139326
2012 Enzyme-catalyzed modification of PES surfaces: reduction in adsorption of BSA, dextrin and tannin. Journal of colloid and interface science 10 22560487
1989 Inhibitory effect of extract of Ipomoea pes-caprae on guinea-pig ileal smooth muscle. Acta pharmaceutica Nordica 10 2597337
2023 PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment. Cancer medicine 9 37076985
2022 In Situ Generation of Fouling Resistant Ag/Pd Modified PES Membranes for Treatment of Pharmaceutical Wastewater. Membranes 9 36005677
2021 Giant Vesicles Produced with Phosphatidylcholines (PCs) and Phosphatidylethanolamines (PEs) by Water-in-Oil Inverted Emulsions. Life (Basel, Switzerland) 9 33801936
2020 microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ. Journal of translational medicine 9 32448371
2011 Giant cell tumor of the pes anserine bursa (extra-articular pigmented villonodular bursitis): a case report and review of the literature. Case reports in medicine 9 21687595
2009 Congenital pes cavus in a Charcot-Marie-tooth disease type 1A newborn. Pediatric neurology 9 19433282
2000 Biodegradable poly(ethylene succinate) (PES). 2. Crystal morphology of melt-crystallized ultrathin film and its change after enzymatic degradation. Biomacromolecules 9 11710202
1999 Conservative management of posterior tibial tendon dysfunction, subtalar joint complex, and pes planus deformity. Clinics in podiatric medicine and surgery 9 10470507
1999 Complexity of developmental control: analysis of embryonic cell lineage specification in Caenorhabditis elegans using pes-1 as an early marker. Genetics 9 9872954
2023 Uncovering the effective substances and mechanism of Ipomoea pes-caprae against rheumatoid arthritis using liquid chromatography-mass spectrometry and targeted network pharmacology. Journal of separation science 8 36772844
2016 Mechanism of Alcohol-Water Dehydrogenative Coupling into Carboxylic Acid Using Milstein's Catalyst: A Detailed Investigation of the Outer-Sphere PES in the Reaction of Aldehydes with an Octahedral Ruthenium Hydroxide. Inorganic chemistry 8 27467132
2007 Light chain 1 of microtubule-associated protein 1B can negatively regulate the action of Pes1. The Journal of biological chemistry 8 17308336
2024 Immobilization of carbonic anhydrase on modified PES membranes for artificial lungs. Journal of materials chemistry. B 7 38345129
2023 SCARECROW-like GRAS protein PES positively regulates petunia floral scent production. Plant physiology 7 36760164
2022 The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells. International journal of molecular sciences 7 36361992
2021 Licochalcone A inhibits cell growth through the downregulation of the Hippo pathway via PES1 in cholangiocarcinoma cells. Environmental toxicology 7 34845814
2019 Formulation and evaluation of letrozole-loaded spray dried liposomes with PEs for topical application. Journal of liposome research 7 31223043
2018 NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells. OncoTargets and therapy 7 30319277
2008 The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial. BMC musculoskeletal disorders 7 18241355
2005 Improved protein-adsorption-resistant property of PES/SPC blend membrane by adjustment of coagulation bath composition. Colloids and surfaces. B, Biointerfaces 7 16343865
2023 Novel Insights from Clinical Practice: Xia-Gibbs Syndrome with Pes Cavus, Conjunctival Melanosis, and Eye Asymmetry due to a de novo AHDC1 Gene Variant - A Case Report and a Brief Review of the Literature. Molecular syndromology 6 38357260
2022 Phytochemistry, biological activities and in silico molecular docking studies of Oxalis pes-caprae L. compounds against SARS-CoV-2. Journal of King Saud University. Science 6 35756195
2022 A high-protein retained PES hemodialysis membrane with tannic acid as a multifunctional modifier. Colloids and surfaces. B, Biointerfaces 6 36252532
2021 How to manage pes cavus in children and adolescents? EFORT open reviews 6 34267941
2020 Probing protein rejection behavior of blended PES-based flat-sheet ultrafiltration membranes: A density functional theory (DFT) study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 6 32388231
1989 The developmental anatomy of pes valgo planus. Clinics in podiatric medicine and surgery 6 2665922
2024 Emerging role of PES1 in disease: A promising therapeutic target? Gene 5 39209183