Affinage

PACSIN2

Protein kinase C and casein kinase substrate in neurons protein 2 · UniProt Q9UNF0

Length
486 aa
Mass
55.7 kDa
Annotated
2026-06-10
27 papers in source corpus 24 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PACSIN2 is an F-BAR domain membrane-sculpting protein that couples plasma membrane remodeling to dynamin-dependent membrane scission and to the actin cytoskeleton across endocytic and cell-junction contexts (PMID:21610094, PMID:25216944). At caveolae, its F-BAR domain directly binds caveolin-1, sculpts caveolar invaginations, and recruits dynamin-2 for fission (PMID:21610094); super-resolution imaging places the PACSIN2 F-BAR closer to the plasma membrane than EHD2 and caveolin-1, positioning it as the link between caveolae and the membrane (PMID:35834519). PKC phosphorylation at serine 313 acts as a switch that reduces PACSIN2 membrane binding and tubulation, shortening caveolar lifetime and triggering dynamin-2-driven caveolae removal, with EHD2 restoring caveolar stability (PMID:26092940). Distinctively among BAR/F-BAR proteins, the PACSIN2 F-BAR binds actin filaments through the same concave surface used for membrane binding (PMID:25216944), and Filamin A binds the F-BAR tip to enhance tubulation and direct PACSIN2 localization (PMID:25838348). Through these activities PACSIN2 drives clathrin-independent and apical endocytosis and regulates surface trafficking of multiple cargoes: it restrains VE-cadherin internalization at tension-bearing adherens junctions by organizing an EHD4/MICAL-L1 recycling-endosome-like tubular structure to coordinate polarized endothelial migration and angiogenic sprouting (PMID:27417273, PMID:33972531), controls nephrin endocytosis and recycling in podocytes (PMID:28550045), limits surface EGFR and downstream Erk/Akt signaling (PMID:23129763), and maintains brush-border microvillar morphology via dynamin-2-dependent apical endocytic scission (PMID:31390291). PACSIN2 negatively regulates Rac1 activity through its membrane-tubulating and dynamin-dependent functions and a Rac1 hypervariable-domain interaction (PMID:21693584), and acts as a scaffold balancing Cobll1 and SH3BP1 to tune Rac1 signaling (PMID:35352878). It negatively regulates integrin β1 activation via Filamin A, with Pacsin2 deletion causing thrombocytopenia and unstable thrombi that are normalized by integrin β1 deletion (PMID:37678551). PACSIN2 also serves as a host factor exploited by pathogens, promoting HIV-1 cell-to-cell spread by linking Gag to actin through its SH3-domain interaction with WASP/N-WASP (PMID:29891700), supporting HCV assembly via NS5A binding (PMID:31801866), and mediating entry of C. difficile TcdA and spread of L. monocytogenes (PMID:27942025, PMID:31242077).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2000 Medium

    Established the earliest functional readout for PACSIN2 as an SH3-domain adaptor that negatively regulates a transmembrane partner during development.

    Evidence Pull-down, colocalization, and developmental rescue with ΔSH3 mutant of Xenopus PACSIN2 against ADAM13

    PMID:11076687

    Open questions at the time
    • Performed on Xenopus ortholog only
    • Did not address membrane-sculpting or endocytic roles
  2. 2008 Medium

    Linked PACSIN2 to integrin β1 and cytoskeletal organization during cell migration, foreshadowing its later integrin-regulatory role.

    Evidence Overexpression and truncation analysis in Xenopus embryos and XTC cells with fibronectin spreading assays

    PMID:18495106

    Open questions at the time
    • Largely overexpression-based
    • Molecular basis of integrin regulation not defined here
  3. 2011 High

    Defined the core mechanism: the F-BAR domain directly binds caveolin-1, sculpts caveolae, and recruits dynamin-2 for fission, establishing PACSIN2 as a caveolar membrane-sculpting protein.

    Evidence Direct F-BAR–caveolin-1 binding, membrane tubulation assay, and siRNA knockdown with morphological readout

    PMID:21610094

    Open questions at the time
    • Did not establish regulatory switch controlling fission timing
    • In vitro tubulation versus physiological caveolar dynamics
  4. 2011 High

    Showed PACSIN2 negatively regulates Rac1 activity through its membrane-tubulating and dynamin-dependent functions, connecting it to migration control.

    Evidence Co-IP, Rac1-GTP pull-down, wound-healing migration assay, and live imaging with interaction- and tubulation-dependent rescue

    PMID:21693584

    Open questions at the time
    • Direct versus endosome-mediated regulation of Rac1 not fully resolved
    • GEF/GAP intermediary not identified in this study
  5. 2014 High

    Revealed that the F-BAR domain binds actin filaments via the same concave surface used for membranes, a property unique to PACSIN2 among tested F-BAR proteins, coupling membrane and cytoskeletal functions.

    Evidence In vitro actin co-sedimentation with mutagenesis of the membrane-binding surface and structural context

    PMID:25216944

    Open questions at the time
    • Competition between membrane and actin binding in cells not quantified
    • Physiological consequence of dual binding not directly tested
  6. 2015 High

    Identified Filamin A as an F-BAR tip-binding partner that enhances tubulation and directs PACSIN2 localization, controlling demarcation membrane formation in megakaryocytes.

    Evidence Reciprocal Co-IP in platelets, in vitro tubulation, and Flna-null mouse morphology

    PMID:25838348

    Open questions at the time
    • Did not connect FlnA interaction to integrin function directly
    • Mechanism of tubulation enhancement not structurally resolved
  7. 2015 High

    Established PKC phosphorylation of S313 as the molecular switch that reduces membrane binding and triggers dynamin-2-dependent caveolae removal, explaining how caveolar lifetime is regulated.

    Evidence S313E phospho-mimetic mutagenesis, live-cell caveolar tracking, PKC activation, and EHD2 rescue

    PMID:26092940

    Open questions at the time
    • In vivo PKC isoform specificity at S313 not fully defined here
    • Crosstalk with actin binding not addressed
  8. 2016 High

    Showed PACSIN2 is recruited by tension to trailing adherens junctions and inhibits VE-cadherin internalization, defining a role in endothelial barrier integrity.

    Evidence siRNA knockdown, photoconversion/FRAP, super-resolution and live-cell imaging, F-BAR mutant analysis

    PMID:27417273

    Open questions at the time
    • Tension-sensing mechanism of recruitment not molecularly defined
    • Trafficking machinery downstream identified only later
  9. 2016 Medium

    Demonstrated PACSIN2 mediates a clathrin- and caveolae-independent but dynamin-dependent endocytic route, exploited by C. difficile toxin A.

    Evidence RNAi knockdown, pharmacological inhibition, and confocal imaging of labeled TcdA

    PMID:27942025

    Open questions at the time
    • Direct toxin–PACSIN2 interaction not shown
    • Cargo selectivity of this pathway unresolved
  10. 2017 Medium

    Extended cargo regulation to nephrin trafficking in podocytes and identified rabenosyn-5 as a partner enhancing the association, with disease-relevant palmitate modulation.

    Evidence Co-IP, colocalization, overexpression endocytosis/recycling assay, and pull-down

    PMID:28550045

    Open questions at the time
    • Relies on overexpression for trafficking readout
    • Endogenous physiological balance of endocytosis versus recycling unclear
  11. 2018 High

    Defined a proviral role where PACSIN2 connects HIV-1 Gag to the actin cytoskeleton via its SH3 domain to promote cell-to-cell spread.

    Evidence VLP incorporation, siRNA knockdown, spreading assay, and SH3-mutant rescue in T cells and PBMCs

    PMID:29891700

    Open questions at the time
    • Structural detail of Gag–SH3 interaction not resolved
    • Whether membrane sculpting contributes alongside SH3 not separated
  12. 2019 High

    Showed PACSIN2-dependent endocytic scission maintains apical microvillar membrane morphology, and supports L. monocytogenes protrusion engulfment.

    Evidence PACSIN2 KO mouse ultrastructure with dynamin-2 mislocalization, and RNAi bacterial spread assay

    PMID:31242077 PMID:31390291

    Open questions at the time
    • Cargo whose endocytosis maintains microvilli not identified
    • Listeria engulfment mechanism only correlative
  13. 2020 High

    Revealed HCV exploitation: NS5A binds the F-BAR region and blocks PKCα-mediated S313 phosphorylation, linking the phospho-switch to viral assembly.

    Evidence Co-IP, domain mapping, S313A mutagenesis, knockdown, and infectivity assays

    PMID:31801866

    Open questions at the time
    • How reduced phosphorylation mechanistically aids assembly not fully defined
    • Role of lipid-droplet ERK1/2 axis only partially mapped
  14. 2021 High

    Identified the PACSIN2/EHD4/MICAL-L1 tubular recycling complex that controls local VE-cadherin trafficking and polarized endothelial migration and sprouting.

    Evidence Co-IP, live imaging, siRNA knockdown, and in vivo zebrafish angiogenesis

    PMID:33972531

    Open questions at the time
    • Assembly hierarchy of the complex not fully ordered
    • Direct versus indirect EHD4/MICAL-L1 binding not separated
  15. 2022 Medium

    Refined the spatial model of caveolae by placing PACSIN2 F-BAR closest to the membrane and identified a Cobll1/SH3BP1 scaffold switch tuning Rac1-dependent drug resistance.

    Evidence Single-molecule super-resolution clustering analysis; competitive Co-IP and apoptosis assays in K562 cells; zebrafish proximal tubule endocytosis

    PMID:35352878 PMID:35616009 PMID:35834519

    Open questions at the time
    • Super-resolution lacked functional perturbation
    • Scaffold competition affinities measured in single system
  16. 2023 High

    Established disease-context roles: S313 phosphorylation regulates podocyte actin via N-WASP, and PACSIN2 restrains platelet integrin β1 via Filamin A in hemostasis.

    Evidence Phospho-specific staining in DKD glomeruli with phospho-mutants; Pacsin2 KO and integrin β1 KO epistasis with thrombosis models and FlnA pull-down

    PMID:37296607 PMID:37678551

    Open questions at the time
    • Kinase/phosphatase cycle governing S313 in vivo not fully mapped
    • How FlnA binding suppresses integrin activation mechanistically unresolved
  17. 2023 Medium

    Implicated PACSIN2 in autophagy inhibition via a putative LIR-LC3-II interaction and in modulation of thiopurine drug response.

    Evidence siRNA knockdown, autophagy flux, LC3-II Co-IP, LIR analysis, and cytotoxicity assays

    PMID:36596605

    Open questions at the time
    • LIR-mediated LC3-II binding described as putative
    • Mechanism linking PACSIN2 to TPMT activity not molecularly defined
  18. 2026 Medium

    Extended PACSIN2 function to neurons, where it cooperates with dynamin to control GluA1 AMPA receptor expression and influences stress-related behavior.

    Evidence Co-IP, region-specific knockdown in dCA1, electrophysiology, and behavioral assays in rats

    PMID:42098399

    Open questions at the time
    • Whether GluA1 regulation reflects endocytic scission not directly shown
    • Single model system

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PACSIN2's dual membrane- and actin-binding F-BAR surface is dynamically partitioned and regulated in vivo, and how a single scission machinery is selectively deployed across caveolae, junctions, podocytes, microvilli, and neurons, remains unresolved.
  • No unified structural model integrating membrane, actin, and phospho-switch states
  • Cargo-selection logic across tissues undefined
  • Endogenous kinase/phosphatase control of S313 in each context unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 2 GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005768 endosome 3 GO:0005886 plasma membrane 3 GO:0005856 cytoskeleton 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-109582 Hemostasis 1
Partners
CAV1DNM2EHD2FLNAMICALL1NPHS1RAC1WASL
Complex memberships
PACSIN2/EHD4/MICAL-L1 tubular recycling complex

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 PACSIN2 F-BAR domain directly interacts with caveolin-1, sculpts caveolar plasma membrane invaginations, and recruits dynamin-2 for caveola fission; knockdown of PACSIN2 causes abnormal caveolin-1-associated plasma membrane morphology and decreased dynamin-2 recruitment. Direct binding assay (F-BAR domain–caveolin-1 interaction), membrane tubulation assay, siRNA knockdown with morphological readout Journal of cell science High 21610094
2011 PACSIN2 associates with the C-terminal hypervariable domain of Rac1 at intracellular tubular structures and early endosomes; loss of PACSIN2 increases Rac1-GTP levels and promotes cell spreading and migration, while ectopic PACSIN2 reduces Rac1-GTP in a manner dependent on the PACSIN2–Rac1 interaction, PACSIN2 membrane-tubulating capacity, and dynamin. Co-immunoprecipitation, siRNA knockdown, wound-healing migration assay, Rac1-GTP pull-down, live-cell imaging Journal of cell science High 21693584
2000 Xenopus PACSIN2 (X-PACSIN2) binds the cytoplasmic domain of ADAM13 via SH3-domain interactions in vitro and colocalizes with ADAM13 in membrane ruffles and cytoplasmic vesicles; PACSIN2 overexpression rescues ADAM13-induced developmental defects, while the truncated ΔSH3 form increases ADAM13 activity, indicating PACSIN2 negatively regulates ADAM13 function via its SH3 domain. Pull-down assay, co-localization in XTC cells, developmental rescue experiment, truncation mutant analysis Developmental biology Medium 11076687
2014 The PACSIN2 F-BAR domain directly binds actin filaments using the same concave surface employed for membrane binding; this interaction is specific to pacsin2 among tested BAR/F-BAR proteins (endophilin, CIP4, FCHO2 did not associate with actin). In vitro actin co-sedimentation, structural analysis (cryo-EM/crystallography implied), mutagenesis of membrane-binding surface EMBO reports High 25216944
2015 Filamin A (FlnA) binds the tip of the PACSIN2 F-BAR domain (requiring FlnA immunoglobulin-like repeat 20) and enhances PACSIN2 F-BAR domain membrane tubulation in vitro; the FlnA–PACSIN2 interaction regulates PACSIN2 localization and demarcation membrane system (DMS) formation in megakaryocytes, and Flna-null platelets show dispersed PACSIN2 foci and poorly defined DMS. Co-immunoprecipitation in human platelets, in vitro membrane tubulation assay, Flna-null mouse model, fluorescence microscopy Blood High 25838348
2015 Protein kinase C (PKC) phosphorylates PACSIN2 at serine 313, reducing its membrane-binding and tubulation capacities; phosphorylation decreases caveolar tracking duration at the plasma membrane and correlates with increased dynamin-2 recruitment and activity, triggering caveolae removal. EHD2 expression restores caveolar stability in PACSIN2-depleted or phospho-mimetic S313E cells. Site-directed mutagenesis (S313E phospho-mimetic), live-cell caveolar tracking, PKC pharmacological activation, RNAi depletion, in vitro membrane binding assay Journal of cell science High 26092940
2016 PACSIN2 concentrates at focal adherens junctions (FAJs) experiencing actomyosin tension, recruited via its F-BAR domain to the trailing end of fast-moving FAJs; PACSIN2 inhibits internalization of VE-cadherin from FAJ trailing ends, and loss of PACSIN2 impairs endothelial monolayer integrity. siRNA knockdown, photoconversion and FRAP microscopy, super-resolution microscopy, live-cell imaging, F-BAR domain mutant analysis Nature communications High 27417273
2016 TcdA (C. difficile toxin A) undergoes PACSIN2-dependent, dynamin-dependent but clathrin- and caveolae-independent endocytosis; TcdA colocalizes with PACSIN2-positive structures during entry, and RNAi knockdown of PACSIN2 inhibits TcdA uptake and downstream cytopathic effects. RNAi knockdown, pharmacological inhibition, confocal microscopy with fluorescently labeled toxin PLoS pathogens Medium 27942025
2018 HIV-1 p6 recruits PACSIN2 into virus-like particles independently of TSG101/ALIX; HIV-1 spreading in T cells and PBMCs is severely impaired upon PACSIN2 depletion and can be restored by wild-type PACSIN2 but not by an SH3-domain mutant unable to interact with WASP/N-WASP, indicating PACSIN2 promotes HIV-1 cell-to-cell spread by connecting Gag to the actin cytoskeleton via its SH3 domain. VLP incorporation assay, siRNA knockdown, spreading assay, SH3 domain mutant rescue experiment Proceedings of the National Academy of Sciences of the United States of America High 29891700
2019 PACSIN2 localizes to L. monocytogenes protrusions and promotes protrusion engulfment during bacterial cell-to-cell spread; RNAi knockdown of PACSIN2 reduces spread efficiency. RNAi screen, fluorescence microscopy, bacterial spread assay Molecular biology of the cell Medium 31242077
2019 PACSIN2 promotes apical endocytosis in intestinal epithelial cells; PACSIN2 KO mice show reduced microvillar numbers and membrane-lifting defects at brush borders, with loss of dynamin-2 from microvillar rootlets; inhibition of endocytosis phenocopies PACSIN2 loss, placing PACSIN2-dependent endocytic scission upstream of microvillar membrane morphology maintenance. PACSIN2 KO mouse, electron microscopy, live-cell endocytosis assay, dynamin2 localization by immunofluorescence Molecular biology of the cell High 31390291
2020 PACSIN2 interacts with HCV NS5A via the NS5A domain I and the PACSIN2 F-BAR region; NS5A prevents PKCα from binding PACSIN2, reducing phosphorylation of PACSIN2 at S313 and enhancing NS5A–PACSIN2 interaction; PACSIN2 is required for HCV assembly (not entry or replication) and promotes NS5A–core protein interaction and lipid droplet formation via ERK1/2. Co-immunoprecipitation, pulldown assay, immunofluorescence, siRNA knockdown, S313A mutagenesis, viral infectivity assay Journal of virology High 31801866
2021 PACSIN2 recruits trafficking regulators EHD4 and MICAL-L1 to the rear end of asymmetric adherens junctions to form a recycling endosome-like tubular structure; this PACSIN2/EHD4/MICAL-L1 complex controls local VE-cadherin trafficking and coordinates polarized endothelial migration and angiogenic sprouting. Co-immunoprecipitation, live-cell imaging, siRNA knockdown, in vivo zebrafish angiogenesis assay Nature communications High 33972531
2017 PACSIN2 colocalizes and physically interacts with nephrin in podocytes; PACSIN2 overexpression increases both nephrin endocytosis and recycling; rabenosyn-5 is identified as a novel PACSIN2 interactor that enhances the PACSIN2–nephrin association; palmitate (elevated in diabetes) further enhances this association. Co-immunoprecipitation, co-localization microscopy, overexpression endocytosis assay, pull-down FASEB journal Medium 28550045
2012 PACSIN2 loss increases plasma membrane expression of EGFR in resting cells and enhances EGF-induced EGFR phosphorylation, Erk and Akt activation, and cell proliferation; internalized EGF and activated EGFR translocate to PACSIN2-positive endosomes, identifying PACSIN2 as a regulator of EGFR surface levels and downstream signaling. siRNA knockdown, surface EGFR quantification, phospho-immunoblotting, proliferation assay, confocal co-localization The Journal of biological chemistry Medium 23129763
2008 Xenopus PACSIN2 localizes to the plasma membrane via its coiled-coil domain; overexpression inhibits gastrulation, fibronectin fibrillogenesis, and ectodermal cell spreading on fibronectin; PACSIN2 overexpression prevents integrin β1 localization to focal adhesions and filamin localization to stress fibers in XTC cells, indicating PACSIN2 regulates activated α5β1 integrin and cytoskeletal organization during cell migration. Overexpression and truncation mutant analysis in Xenopus embryos, immunofluorescence, cell spreading assay on fibronectin, mitochondria-anchoring sequestration experiment Developmental biology Medium 18495106
2022 PACSIN2 acts as a scaffold in CML cells: it binds Cobll1 and separately binds and inhibits SH3BP1 (a Rac1 pathway activator); Cobll1 preferentially competes with SH3BP1 for PACSIN2 binding, releasing SH3BP1 to activate Rac1 signaling and suppress TKI-induced apoptosis, leading to drug resistance. Co-immunoprecipitation, competitive binding assay, siRNA knockdown, apoptosis assay in K562 cells Cancer medicine Medium 35352878
2022 Super-resolution microscopy shows that PACSIN2 and EHD2 both localize at caveolin-1-positive caveolae, with PACSIN2 F-BAR domain positioned closer to the plasma membrane than EHD2 and caveolin-1, suggesting PACSIN2 connects caveolae to the plasma membrane; PACSIN2 and EHD2 are present predominantly at typically sized (full-volume) caveolae. Single-molecule localization super-resolution (3D-STORM/PALM), spatial proximity clustering analysis PloS one Medium 35834519
2023 PACSIN2 inhibits autophagy, putatively by interacting with LC3-II via a LIR motif to inhibit autophagosome formation; knockdown of PACSIN2 modulates mercaptopurine-induced cytotoxicity in intestinal cells; PACSIN2 modulates cellular TPMT activity via mechanisms distinct from its autophagy regulation. siRNA knockdown, autophagy flux assay, co-immunoprecipitation (PACSIN2–LC3-II), LIR motif analysis, cytotoxicity assay Life science alliance Medium 36596605
2023 PACSIN2 phosphorylation at S313 is increased in diabetic kidney disease glomeruli; pS313-PACSIN2 decreases N-WASP degradation; N-WASP inhibition reciprocally triggers PACSIN2 S313 phosphorylation; pS313-PACSIN2 regulates actin cytoskeleton rearrangement in podocytes, and the dynamic phosphorylation cycle is required for podocyte morphology maintenance. Phospho-specific antibody staining in rat DKD glomeruli, pharmacological N-WASP inhibition, phospho-mimetic and phospho-dead PACSIN2 mutants, actin cytoskeleton imaging Cells Medium 37296607
2023 PACSIN2 negatively regulates platelet integrin β1 hemostatic function through its interaction with filamin A; Pacsin2-/- mice display thrombocytopenia, prolonged bleeding, unstable thrombi, and hyperactive integrin β1; genetic deletion of integrin β1 in Pacsin2-/- mice normalizes platelet count, hemostasis, and thrombus formation, placing PACSIN2 upstream of integrin β1 activation. Pacsin2 KO mouse, integrin β1 KO epistasis, ferric chloride and laser injury thrombosis models, spreading assay on GFOGER, active integrin β1 antibody (9EG7) staining, FlnA-binding peptide pull-down Journal of thrombosis and haemostasis High 37678551
2022 In zebrafish larvae, pacsin2 is enriched at the apical pole of renal proximal tubule cells at endocytic structures; loss of pacsin2 reduces endocytosis in the proximal tubule and decreases abundance of megalin and endocytic organelles. Pacsin2 morpholino knockdown in zebrafish, fluorescence microscopy, endocytosis assay, megalin immunostaining Biology open Medium 35616009
2026 In hippocampal CA1 neurons, chronic stress upregulates PACSIN2; PACSIN2 physically interacts with dynamin and cooperatively modulates postsynaptic GluA1 AMPA receptor expression; selective knockdown of PACSIN2 in dCA1 enhances synaptic transmission and ameliorates depression-like behaviors in rats. Co-immunoprecipitation (PACSIN2–dynamin), viral-vector-mediated knockdown in dCA1, electrophysiology, behavioral assays Acta pharmacologica Sinica Medium 42098399
2012 PACSIN2 knockdown in human leukemia cells (NALM6) results in significantly lower TPMT activity, and a PACSIN2 SNP (rs2413739) is associated with altered TPMT activity in patients; protein-level correlation between PACSIN2 and TPMT was detected in PBMCs. siRNA knockdown with TPMT activity assay, genome-wide association in HapMap cell lines, patient cohort validation Human molecular genetics Medium 22846425

Source papers

Stage 0 corpus · 27 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting. Journal of cell science 120 21610094
2011 The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. Journal of cell science 76 21693584
2012 PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. Human molecular genetics 61 22846425
2000 PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13. Developmental biology 58 11076687
2014 Direct interaction of actin filaments with F-BAR protein pacsin2. EMBO reports 50 25216944
2015 FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood 49 25838348
2015 Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane. Journal of cell science 41 26092940
2016 The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions. Nature communications 40 27417273
2016 Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis. PLoS pathogens 35 27942025
2021 A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. Nature communications 34 33972531
2017 PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32 28550045
2012 The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. The Journal of biological chemistry 29 23129763
2019 RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread. Molecular biology of the cell 22 31242077
2016 PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy. Scientific reports 22 27452984
2019 PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients. The pharmacogenomics journal 21 31792371
2018 HIV-1 gag recruits PACSIN2 to promote virus spreading. Proceedings of the National Academy of Sciences of the United States of America 20 29891700
2019 PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli. Molecular biology of the cell 17 31390291
2008 PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis. Developmental biology 16 18495106
2015 Possible regulation of caveolar endocytosis and flattening by phosphorylation of F-BAR domain protein PACSIN2/Syndapin II. Bioarchitecture 15 26745030
2020 PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. Journal of virology 10 31801866
2023 PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells. Life science alliance 7 36596605
2022 Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. Cancer medicine 7 35352878
2022 Super-resolution analysis of PACSIN2 and EHD2 at caveolae. PloS one 6 35834519
2022 Pacsin2 is required for endocytosis in the zebrafish pronephric tubule. Biology open 2 35616009
2023 Phosphorylation of PACSIN2 at S313 Regulates Podocyte Architecture in Coordination with N-WASP. Cells 1 37296607
2023 PACSIN2 regulates platelet integrin β1 hemostatic function. Journal of thrombosis and haemostasis : JTH 1 37678551
2026 PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress. Acta pharmacologica Sinica 0 42098399

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