Affinage

PABPC4

Polyadenylate-binding protein 4 · UniProt Q13310

Round 2 corrected
Length
644 aa
Mass
70.8 kDa
Annotated
2026-04-29
123 papers in source corpus 23 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PABPC4 is a cytoplasmic poly(A)-binding protein that stabilizes mRNAs and promotes their translation by binding poly(A) tails and AU-rich 3′UTR elements through its RRM3/4 domains, functioning as an inducible counterpart to constitutive PABPC1 (PMID:8524242, PMID:14717712). It enhances translation of specific mRNAs—including IL-2, hTERT, and erythroid transcripts—in a poly(A)-tail-dependent manner that is negatively regulated by the anti-proliferative factor Tob and by MKRN3-mediated ubiquitination, which attenuates poly(A) binding to suppress GnRH1 translation during puberty timing (PMID:15676026, PMID:33744966, PMID:24469397). PABPC4 also serves as a broad-spectrum antiviral restriction factor that recruits the E3 ligase MARCH8 to ubiquitinate coronavirus nucleocapsid proteins, targeting them for NDP52-directed selective autophagic degradation, and mediates TRIM25-dependent antiviral activity against alphaviruses (PMID:34612687, PMID:36067236). Beyond canonical mRNA regulation, PABPC4 stabilizes the NCoR1 corepressor to modulate PPAR-driven oxidative metabolism and, together with PABPC1, protects poly(A) tails from CCR4-NOT deadenylation to buffer the global transcriptome during mitotic arrest (PMID:37059182, PMID:41256622).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1995 High

    Discovery that poly(A)-binding activity is not solely constitutive: identification of PABPC4 as an inducible cytoplasmic PABP in activated T cells established that PABP function is dynamically regulated in response to immune signals.

    Evidence cDNA cloning, Northern blot, and immunofluorescence in resting vs. activated human T cells

    PMID:8524242

    Open questions at the time
    • Stimulus-specific transcriptional/translational regulation of PABPC4 induction not defined
    • Functional distinction from PABPC1 at the mRNA level not resolved
  2. 2004 High

    Resolved how PABPC4 engages non-poly(A) RNA: RRM3/4 confer AU-rich element binding with lower sequence discrimination than PABPC1, explaining how PABPC4 can protect AU-rich mRNAs beyond the poly(A) tail.

    Evidence In vitro RNA binding assays with recombinant domain-deletion constructs measuring Kd

    PMID:14717712

    Open questions at the time
    • No structural data for the RRM3/4–ARE complex
    • In vivo target specificity governed by RRM3/4 vs. full-length protein not determined
  3. 2005 High

    Established PABPC4 as a translational enhancer and identified a negative regulatory mechanism: PABPC4 stimulates IL-2 mRNA translation in a 3′UTR/poly(A)-dependent manner, and the anti-proliferative factor Tob counteracts this by binding the PABPC4 C-terminus.

    Evidence GST pulldown, co-IP, and in vitro translation assay with and without Tob co-expression

    PMID:15676026

    Open questions at the time
    • Physiological relevance of Tob–PABPC4 interaction during T-cell activation not tested in vivo
    • Whether Tob triggers deadenylation or blocks eIF4G recruitment via PABPC4 unresolved
  4. 2014 High

    Demonstrated a lineage-specific role: PABPC4 preferentially associates with short-poly(A)-tail, AU-rich erythroid mRNAs and is required for terminal erythroid differentiation, extending its function beyond immune cell activation.

    Evidence RIP, RNA-seq, shRNA knockdown with erythroid maturation assays in erythroblast cell lines

    PMID:24469397

    Open questions at the time
    • In vivo erythropoiesis phenotype in PABPC4-null animals not fully characterized at the time
    • Mechanistic distinction from PABPC1 in erythroid cells unclear
  5. 2021 High

    Revealed PABPC4 as a broad-spectrum antiviral restriction factor operating through selective autophagy: PABPC4 recruits the E3 ligase MARCH8 to ubiquitinate coronavirus nucleocapsid proteins, which are then recognized by NDP52 for autophagic degradation.

    Evidence Co-IP, ubiquitination assays, autophagy inhibition, knockdown/overexpression with viral replication readout across coronavirus genera

    PMID:34612687 PMID:40266995

    Open questions at the time
    • Whether PABPC4's RNA-binding activity is required for N protein recognition is unknown
    • Applicability to non-coronavirus RNA viruses not tested via this pathway
  6. 2021 High

    Identified a regulatory circuit linking MKRN3 ubiquitination of PABPC4 to puberty onset: MKRN3 ubiquitinates PABPC4 to reduce its poly(A)-binding capacity, shortening GNRH1 mRNA poly(A) tails and suppressing GnRH1 translation.

    Evidence Co-IP, ubiquitination assays, poly(A) tail-length assay, translation initiation complex assay with MKRN3 loss-of-function

    PMID:33744966

    Open questions at the time
    • Specific ubiquitin chain type and site(s) on PABPC4 not mapped
    • Whether other PABPCs fully compensate when PABPC4 is ubiquitinated in vivo
  7. 2022 Medium

    Extended the antiviral paradigm: PABPC4 was identified as a TRIM25 ubiquitination substrate required for TRIM25-dependent alphavirus restriction, establishing a second E3-ligase-mediated antiviral axis.

    Evidence Substrate trapping with catalytic-mutant TRIM25, co-IP, knockdown with viral replication readout

    PMID:36067236

    Open questions at the time
    • Ubiquitination sites and functional consequence (degradation vs. activity change) not defined
    • Whether TRIM25–PABPC4 axis operates via autophagy or another mechanism unknown
  8. 2023 High

    Uncovered a non-canonical role in metabolic regulation: PABPC4 stabilizes the NCoR1 corepressor, and its loss causes NCoR1 ubiquitination/degradation, derepressing PPAR target genes and increasing mitochondrial oxidative metabolism.

    Evidence Reciprocal co-IP, siRNA knockdown, ubiquitination assay, oxygen consumption and lipid staining in two cell lines

    PMID:37059182

    Open questions at the time
    • Whether PABPC4 stabilizes NCoR1 mRNA, protein, or both is not fully dissected
    • Physiological contexts in which PABPC4 reduction drives metabolic reprogramming in vivo unknown
  9. 2023 Medium

    Identified PABPC4 as an NMD antagonist: PABPC4 protects FAM134B mRNA from nonsense-mediated decay, and circFAM134B sequesters PABPC4 to relieve this protection, linking PABPC4 to reticulophagy and ferroptosis regulation in hepatocellular carcinoma.

    Evidence RNA pull-down, RIP, NMD luciferase reporter, siRNA knockdown in HCC cells

    PMID:37603831

    Open questions at the time
    • Generality of PABPC4 as NMD antagonist beyond FAM134B not assessed
    • Quantitative contribution of PABPC4 vs. PABPC1 in NMD suppression unknown
  10. 2025 Medium

    Established that PABPC4 and PABPC1 together are required for global poly(A) tail protection during mitosis: co-depletion destabilizes the transcriptome and disrupts mitotic arrest, and PABPC concentration tunes Pumilio-mediated mRNA repression by modulating CCR4-NOT accessibility.

    Evidence siRNA depletion, mRNA half-life and poly(A) profiling in mitotic vs. interphase cells; tethering and reporter assays for PUM activity (preprint)

    PMID:41256622 PMID:bio_10.1101_2025.07.22.666109

    Open questions at the time
    • Individual contribution of PABPC4 vs. PABPC1 to mitotic mRNA buffering not resolved
    • Findings from preprints, awaiting peer review

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis for PABPC4's preferential binding to AU-rich vs. poly(A) substrates, the full catalog of ubiquitination sites and chain types that regulate its activity, and the in vivo physiological consequences of PABPC4 loss across tissues remain major open questions.
  • No high-resolution structure of PABPC4 or its RNA complexes
  • Comprehensive in vivo phenotyping of tissue-specific knockouts incomplete
  • Relative functional redundancy with PABPC1 not quantified genome-wide

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0045182 translation regulator activity 3 GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005829 cytosol 2
Pathway
R-HSA-8953854 Metabolism of RNA 6 R-HSA-168256 Immune System 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-9612973 Autophagy 2 GO:0003723 RNA binding 1 R-HSA-1640170 Cell Cycle 1
Partners
MARCH8MKRN3NCOR1NDP52PABPC1TOB1TRIM25

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 PABPC4 (iPABP) was identified as an inducible poly(A)-binding protein expressed at low levels in resting T cells but rapidly upregulated following T-cell activation; it is primarily localized to the cytoplasm and shows high expression in heart and skeletal muscle, suggesting that cytoplasmic poly(A)-binding activity is regulated by both constitutive PABP and inducible PABPC4. cDNA library cloning, Northern blot, subcellular fractionation/immunofluorescence Molecular and cellular biology High 8524242
2004 PABPC4 (iPABP) binds AU-rich RNA through RNA recognition motif domains 3 and 4 (rather than domains 1 and 2), and shows even less discrimination between AU-rich and oligo(A) RNA than PABPC1, suggesting it can interact with mRNA regions beyond the poly(A) tail. In vitro RNA binding assays with recombinant truncated PABPC4, affinity measurements (Kd) European journal of biochemistry High 14717712
2005 PABPC4 (iPABP) interacts with the anti-proliferative protein Tob via Tob binding to the C-terminal region of PABPC4; PABPC4 enhances translation of IL-2 mRNA in vitro in a manner requiring the 3'UTR and poly(A) tail, and Tob abrogates this translational enhancement through its interaction with PABPC4. GST pulldown, co-immunoprecipitation, in vitro translation assay, overexpression in NIH3T3 cells Genes to cells High 15676026
2010 PABPC4 is required for the posttranscriptional regulation of hTERT mRNA by HPV16 E6 and NFX1-123; overexpression of PABPC4 increases hTERT mRNA levels and telomerase activity in HPV16 E6-expressing keratinocytes, while knockdown decreases them, leading to a growth advantage. siRNA knockdown, overexpression, RT-qPCR, telomerase activity assay, cell growth assay Journal of virology Medium 20943973
2014 PABPC4 is expressed in erythroid cells and impacts steady-state expression of a subset of erythroid mRNAs; PABPC4 preferentially associates with mRNAs bearing AU-rich motifs in their 3'UTRs when poly(A) tails are critically shortened, potentially protecting them from accelerated decay; selective depletion of PABPC4 in an erythroblast cell line inhibits terminal erythroid maturation. RNA immunoprecipitation, motif analysis, shRNA knockdown in erythroblast cell line, gene expression profiling, differentiation assays Molecular and cellular biology High 24469397
2021 PABPC4 broadly inhibits replication of coronaviruses from all four genera by targeting the nucleocapsid (N) protein for degradation via selective autophagy; mechanistically, PABPC4 recruits the E3 ubiquitin ligase MARCH8/MARCHF8 to ubiquitinate the N protein, which is then recognized by the cargo receptor NDP52/CALCOCO2 and delivered to autolysosomes for degradation. PABPC4 expression is regulated by transcription factor SP1. Co-IP, Western blot, autophagy inhibition assays, overexpression/knockdown with viral replication readout, ubiquitination assays Microbiology spectrum High 34612687
2021 MKRN3 mediates ubiquitination of PABPC4 (along with PABPC1 and PABPC3); MKRN3-mediated ubiquitination of PABPC4 attenuates its binding to poly(A) tails of GNRH1 mRNA, leading to shortened poly(A) tail length of GNRH1 mRNA and impaired formation of the translation initiation complex, thereby post-transcriptionally suppressing GnRH1 expression relevant to puberty initiation. Co-IP, ubiquitination assays, poly(A) tail-length assay, translation initiation complex assay, MKRN3 loss-of-function Nucleic acids research High 33744966
2022 PABPC4 is a substrate of TRIM25 E3 ubiquitin ligase; TRIM25 ubiquitinates PABPC4, and knockdown of PABPC4 diminishes TRIM25's antiviral activity against alphaviruses, establishing PABPC4 as a mediator of TRIM25-dependent antiviral restriction. Substrate trapping with TRIM25 catalytic mutant (R54P), co-IP, knockdown with viral replication readout PLoS pathogens Medium 36067236
2023 PABPC4 interacts with the nuclear receptor corepressor NCoR1; silencing PABPC4 increases ubiquitination and degradation of NCoR1, leading to derepression of PPAR-regulated genes, increased oxidative metabolism (oxygen consumption, mitochondrial content), reduced lactate production, reduced intracellular lipid droplets, and reduced cell death. PABPC4 protein levels are markedly reduced under conditions that induce mitochondrial biogenesis. Co-IP (PABPC4–NCoR1 interaction), siRNA knockdown, ubiquitination assays, oxygen consumption measurement, lipid staining, qPCR of PPAR-regulated genes The Journal of biological chemistry High 37059182
2023 PABPC4 is recognized by RNA-binding protein PABPC4 itself (and specifically, LINC00493 mRNA is recognized by PABPC4 and transferred to ribosomes for translation of the microprotein SMIM26), establishing a role for PABPC4 in facilitating translation of a specific lncRNA-encoded microprotein. RNA immunoprecipitation, ribosome fractionation, knockdown EMBO reports Medium 37009826
2023 PABPC4 acts as an antagonist of the nonsense-mediated mRNA decay (NMD) mechanism for FAM134B mRNA; circFAM134B competitively sequesters PABPC4, thus relieving PABPC4-mediated protection of FAM134B mRNA from NMD, leading to FAM134B mRNA decay and altered reticulophagy-mediated ferroptosis in hepatocellular carcinoma cells. RNA pull-down, mass spectrometry, RNA immunoprecipitation, luciferase NMD reporter assay, siRNA knockdown Cell cycle Medium 37603831
2020 The lncRNA RP11-286H15.1 binds to PABPC4 (at nucleotides 620–750) and promotes its ubiquitination, reducing the stability of TRIM37 and CDC27 mRNAs that are normally stabilized by PABPC4, thereby suppressing HCC progression. RNA pulldown, RIP, ubiquitination assay, Western blot, in vivo/in vitro functional assays Cancer letters Medium 33259899
2018 Suppression of miR-192-5p leads to increased PABPC4 expression in hepatocellular carcinoma, which promotes cancer stem cell features; PABPC4 is a direct target of miR-192-5p, and the circuit from hypermethylation of the mir-192 promoter through increased PABPC4 is a shared regulatory pathway in various groups of primary CSC+ HCC. miRNA profiling, luciferase reporter assay (miR-192-5p targeting PABPC4 3'UTR), siRNA knockdown, promoter methylation analysis, functional CSC assays Cancer research Medium 30530815
2021 LncRNA Lnc-PCIR blocks PABPC4 proteasome-dependent ubiquitination degradation, stabilizing PABPC4; elevated PABPC4 then increases the stability of TAB3 mRNA and disrupts the TAB3–TAB2 binding, activating the TNF-α/NF-κB pathway in triple-negative breast cancer cells. RNA pulldown, RIP, RNA-seq, Western blot, ubiquitination assay, co-IP Frontiers in oncology Medium 34012913
2025 PABPC4 inhibits SADS-CoV replication by targeting the N protein for degradation via selective autophagy, recruiting MARCHF8 (E3 ubiquitin ligase) to ubiquitinate the N protein, which is then recognized by NDP52/CALCOCO2 for autophagic degradation. Co-IP, Western blot, ubiquitination assays, knockdown/overexpression with viral replication readout Veterinary sciences Medium 40266995
2025 In a mammalian (mouse) in vivo model, PABPC4 is not essential for development but its loss affects birth weight, post-natal growth trajectories (in a sexually dimorphic manner), and survival; PABPC4 loss leads to microcytic red blood cells but not reduced haemoglobin, and conditional genetic approaches showed this is not a red blood cell-intrinsic effect, challenging cell-based model predictions of a direct role in haemoglobin synthesis. Germline knockout mouse, conditional knockout, blood count analysis, growth phenotyping bioRxivpreprint Medium bio_10.1101_2025.11.22.689676
2025 During prolonged mitotic arrest, mRNA stabilization is dependent on cytoplasmic poly(A)-binding proteins PABPC1 and PABPC4; depletion of PABPC1&4 disrupts maintenance of mitotic arrest and destabilizes mRNAs, demonstrating that PABPC4 (together with PABPC1) is required for global transcriptome buffering during mitosis by protecting poly(A) tails from deadenylation. siRNA depletion of PABPC1/4, mRNA half-life measurement in mitosis vs. interphase, poly(A) tail profiling, mitotic arrest assays bioRxivpreprint Medium bio_10.1101_2025.07.22.666109
2025 PABPC1 and PABPC4 are both required for Pumilio (PUM1/2)-mediated repression of target mRNAs; in the absence of PABPCs, both PUM targets and non-targets become unstable, bypassing PUM control; increasing PABPC inhibits PUM activity in a concentration-dependent manner by stabilizing poly(A) tails against CCR4-NOT deadenylation. siRNA depletion, mRNA stability assays, reporter assays, PUM2 co-IP with PABPCs, tethering assays bioRxivpreprint Medium 41256622
2024 PABPC4 was identified in CLIP-seq datasets as having binding sites within full-length excised linear intron (FLEXI) RNAs in the cytoplasm; cell fractionation experiments showed cytoplasmic enrichment of FLEXIs with PABPC4 binding sites, suggesting PABPC4 interacts with this class of structured intron RNAs in the cytoplasm. Analysis of public CLIP-seq datasets, cell fractionation, TGIRT-seq PLoS genetics Low 39325823
2024 PABPC4 was found to be responsible for some of the repressive activity of the HPV-1a late 3'UTR on gene expression in keratinocytes, as demonstrated by siRNA depletion reducing 3'UTR-mediated repression of a reporter gene. siRNA depletion, beta-galactosidase reporter assay, bioinformatics (RBPmap) Biomedical reports Low 39006509
2021 PABPC4 was identified as a host interaction partner of ORFV ORF047 (Orf virus L1R protein) via yeast two-hybrid screening and Co-IP, suggesting a role in viral mRNA translation and replication. Yeast two-hybrid cDNA library screen, co-immunoprecipitation Virology journal Low 33499896
2020 PABPC4 was identified as a physical interactor of SARS-CoV-2 N protein by affinity-purification mass spectrometry in human cells expressing tagged viral proteins. Affinity-purification mass spectrometry (AP-MS) Nature Low 32353859
2012 PABPC4 was identified as part of the nucleo-cytoplasmic transport cycle of PABPs; its steady-state cytoplasmic localization can be altered by cellular stresses (UV radiation, viral infection) leading to nuclear accumulation, and its interaction with mRNA and translation complexes is important in determining its sub-cellular distribution. Review/integrated model based on prior experimental data; localization studies Communicative & integrative biology Low 22896784

Source papers

Stage 0 corpus · 123 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 3411 32353859
2010 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2873 20686565
2013 Discovery and refinement of loci associated with lipid levels. Nature genetics 2409 24097068
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
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2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
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2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2020 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 564 33060197
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
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2010 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of proteome research 422 20020773
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1983 Inhibition of brain adenylate cyclase by A1 adenosine receptors: pharmacological characteristics and locations. Brain research 81 6305455
1995 iPABP, an inducible poly(A)-binding protein detected in activated human T cells. Molecular and cellular biology 74 8524242
2018 miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features. Cancer research 70 30530815
2021 MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty. Nucleic acids research 64 33744966
2005 Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. Genes to cells : devoted to molecular & cellular mechanisms 64 15676026
2004 Human PABP binds AU-rich RNA via RNA-binding domains 3 and 4. European journal of biochemistry 63 14717712
2005 Novel DNA-binding properties of the RNA-binding protein TIAR. Nucleic acids research 58 16091628
2005 Kunitz-type Bauhinia bauhinioides inhibitors devoid of disulfide bridges: isolation of the cDNAs, heterologous expression and structural studies. Biological chemistry 57 16006243
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2007 Identification of ACE-inhibitory peptides in salt-free soy sauce that are transportable across caco-2 cell monolayers. Peptides 44 18160180
2021 PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy. Microbiology spectrum 43 34612687
2016 Energy Dissipation of Moving Drops on Superhydrophobic and Superoleophobic Surfaces. Langmuir : the ACS journal of surfaces and colloids 41 28001428
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2014 Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Molecular and cellular biology 39 24469397
2001 Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 39 11560483
2015 Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein. PloS one 38 25768928
2020 A novel long non-coding RNA RP11-286H15.1 represses hepatocellular carcinoma progression by promoting ubiquitination of PABPC4. Cancer letters 35 33259899
2006 The permeability and cytotoxicity of insulin-mimetic vanadium (III,IV,V)-dipicolinate complexes. Journal of inorganic biochemistry 35 16321441
2001 Biochemical characterization and expression analysis of the Xenopus laevis corticotropin-releasing hormone binding protein. Molecular and cellular endocrinology 35 11223175
2001 A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. Genomics 35 11374897
2023 LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma. EMBO reports 34 37009826
2010 Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes. Journal of virology 32 20943973
2022 Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes. PLoS pathogens 30 36067236
2000 Assessment of rate of drug release from oil vehicle using a rotating dialysis cell. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 30 11042228
2022 Synthesis, Characterization, Crystal Structure, DNA and HSA Interactions, and Anticancer Activity of a Mononuclear Cu(II) Complex with a Schiff Base Ligand Containing a Thiadiazoline Moiety. ACS omega 29 35097283
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2020 Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo. The EMBO journal 21 33231880
2012 An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins. Communicative & integrative biology 20 22896784
2004 Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells. European journal of nutrition 20 15316828
2019 No evidence for interactions of dimethylfumarate (DMF) and its main metabolite monomethylfumarate (MMF) with human cytochrome P450 (CYP) enzymes and the P-glycoprotein (P-gp) drug transporter. Pharmacology research & perspectives 18 31832203
2013 Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success. Molecular & cellular proteomics : MCP 18 23938467
2010 Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation. European journal of pharmacology 18 20883690
2009 Capsaicin promotes the amyloidogenic route of brain amyloid precursor protein processing. Neurochemistry international 18 19428784
2001 Production, purification, and properties of an endoglucanase produced by the hyphomycete Chalara (Syn. Thielaviopsis) paradoxa CH32. Journal of agricultural and food chemistry 18 11170563
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2023 Transcriptome-wide association study-derived genes as potential visceral adipose tissue-specific targets for type 2 diabetes. Diabetologia 16 37540242
2019 The Molecular Misreading of APP and UBB Induces a Humoral Immune Response in Alzheimer's Disease Patients with Diagnostic Ability. Molecular neurobiology 16 31654319
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2023 circFAM134B is a key factor regulating reticulophagy-mediated ferroptosis in hepatocellular carcinoma. Cell cycle (Georgetown, Tex.) 15 37603831
2010 Misframed proteins and neurodegeneration: a novel view on Alzheimer's and Parkinson's diseases. Neuro-degenerative diseases 15 20173331
2010 Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers. Xenobiotica; the fate of foreign compounds in biological systems 15 20979451
2003 Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology. The Journal of biological chemistry 15 12900421
1996 Differential effects of trilostane and cyanoketone on the 3 beta-hydroxysteroid dehydrogenase-isomerase reactions in androgen and 16-androstene biosynthetic pathways in the pig testis. The Journal of steroid biochemistry and molecular biology 15 8809191
2015 Studies on the purification of polypeptide from sika antler plate and activities of antitumor. BMC complementary and alternative medicine 14 26383170
2022 Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 13 35006347
2019 Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy. Molecules (Basel, Switzerland) 13 30641935
2019 Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. The Journal of biological chemistry 13 31292192
2022 Mixed Ligand Mononuclear Copper(II) Complex as a Promising Anticancer Agent: Interaction Studies with DNA/HSA, Molecular Docking, and In Vitro Cytotoxicity Studies. ACS omega 12 35785271
2019 The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach. Molecular pharmaceutics 11 31560549
2018 Strap associates with Csde1 and affects expression of select Csde1-bound transcripts. PloS one 11 30138317
2004 Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40. Journal of neurochemistry 11 15255950
2000 Molecular misreading. A new type of transcript mutation in gerontology. Annals of the New York Academy of Sciences 11 10911966
2017 18F-Labeled Pyrido[3,4-d]pyrimidine as an Effective Probe for Imaging of L858R Mutant Epidermal Growth Factor Receptor. ACS medicinal chemistry letters 10 28435529
2015 Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation. Scientific reports 10 26310847
2002 Membrane fusion induced by the major lipid-binding domain of the cytoskeletal protein talin. Biochemical and biophysical research communications 10 12099686
1999 Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. Human genetics 10 10543404
2018 Solid-State Associative Reactions and the Coordination Compression Mechanism. Inorganic chemistry 9 29979043
2023 Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression. International journal of molecular sciences 7 37511575
2023 Mechanism of Intestinal Epithelial Absorption and Electrophysiological Regulation of the Shrimp Peptide QMDDQ. Journal of agricultural and food chemistry 7 38155399
2021 Identification and screening of host proteins interacting with ORFV-ORF047 protein. Virology journal 7 33499896
2021 LncRNA PCIR Is an Oncogenic Driver via Strengthen the Binding of TAB3 and PABPC4 in Triple Negative Breast Cancer. Frontiers in oncology 7 34012913
2020 Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorganic & medicinal chemistry 7 32631562
2005 Alzheimer-associated APP+1 transgenic mice: frameshift beta-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology. Neurobiology of aging 7 16214267
2023 Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. The Journal of biological chemistry 6 37059182
2019 Identification of lipid-like salicylic acid-based derivatives as potent and membrane-permeable PTP1B inhibitors. Bioorganic chemistry 6 31585268
2024 Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers. PLoS genetics 5 39325823
2022 Discovery of 3'-O-β-Glucosyltubercidin and the Nucleoside Specific Glycosyltransferase AvpGT through Genome Mining. ACS chemical biology 5 36356213
2023 Genome-wide search identified DNA methylation sites that regulate the metabolome. Frontiers in genetics 4 37274792
2023 Multiple RNA-binding proteins associated with long interspersed element-1 encoded ORF1p are targeted by the autoimmune response in systemic lupus erythematosus. Journal of cellular and molecular immunology 4 39606792
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2025 PABPC4 Inhibits SADS-CoV Replication by Degrading the Nucleocapsid Protein Through Selective Autophagy. Veterinary sciences 3 40266995
2022 Proline-specific aminopeptidase P prevents replication-associated genome instability. PLoS genetics 3 35081133
2022 Interplay between β-Diimino and β-Diketiminato Ligands in Nickel Complexes Active in the Proton Reduction Reaction. Inorganic chemistry 3 36196853
2023 The Effect of an Adapted Digital Mental Health Intervention for Sickle Cell Disease on Engagement: A Pilot Randomized Controlled Trial. Research square 2 37461733
2025 Evaluating the Immunogenic Potential of ApxI and ApxII from Actinobacillus pleuropneumoniae: An Immunoinformatics-Driven Study on mRNA Candidates. Veterinary sciences 1 40431507
2024 Alternative Polyadenylation Regulatory Factors Signature for Survival Prediction in Kidney Renal Cell Carcinoma. Cancer informatics 1 38617569
2021 The long non-coding RNA MEG3 plays critical roles in the pathogenesis of cholesterol gallstone. PeerJ 1 33665015
2026 Discovery of a novel IMS48 as a dual inhibitor of acetylcholinesterase and butyrylcholinesterase: In vitro and in vivo study for Alzheimer therapy. Neuropharmacology 0 41628818
2026 Association of post-transcriptional regulatory gene single nucleotide polymorphisms with Alzheimer's disease. Journal of Alzheimer's disease : JAD 0 41761645
2025 Novel non-synonymous and synonymous gene variants of SRD5A2 in patients with 46,XY-DSD and DSD-free subjects. PloS one 0 40043094
2025 Elevated PABPC4 expression in human prostate cancer tissues predicts adverse clinical outcomes. Translational andrology and urology 0 40800098
2025 Cytoplasmic poly-adenosine binding proteins modulate susceptibility of mRNAs to RNA-binding protein-directed decay. bioRxiv : the preprint server for biology 0 41256622
2024 Identifying regulatory elements and their RNA-binding proteins in the 3' untranslated regions of papillomavirus late mRNAs. Biomedical reports 0 39006509