Affinage

PABPC4

Polyadenylate-binding protein 4 · UniProt Q13310

Length
644 aa
Mass
70.8 kDa
Annotated
2026-06-10
92 papers in source corpus 20 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PABPC4 (iPABP/APP-1) is a cytoplasmic poly(A)-binding protein with four RNA recognition motifs that regulates mRNA stability and translation, functioning broadly in poly(A)-tail protection and selective transcript control (PMID:9030741, PMID:14717712). First identified as an inducible poly(A)-binding protein upregulated upon T-cell activation and abundant in heart and skeletal muscle (PMID:8524242), it binds both poly(A) and AU-rich RNA, discriminating between them only weakly and thereby engaging RNA regions beyond the poly(A) tail (PMID:14717712). Through its C-terminal region PABPC4 enhances translation of IL-2 mRNA in a 3'UTR- and poly(A)-dependent manner, an activity abrogated when the antiproliferative protein Tob binds the same C-terminal region (PMID:15676026). It stabilizes subsets of mRNAs bearing AU-rich 3'UTR motifs—including erythroid transcripts when poly(A) tails are critically shortened, where its depletion blocks terminal erythroid maturation (PMID:24469397)—and, redundantly with PABPC1, maintains poly(A)-tail length and global transcriptome stability during prolonged mitotic arrest (PMID:41641701). PABPC4 protects poly(A) from CCR4-NOT deadenylation in a concentration-dependent manner, an activity required for Pumilio (PUM1/2)-mediated repression of target mRNAs (PMID:41641701). Beyond translational control, PABPC4 binds the nuclear receptor corepressor NCoR1 and limits its ubiquitin-dependent degradation, thereby restraining PPAR-regulated mitochondrial gene expression and oxidative metabolism (PMID:37059182). PABPC4 also exerts antiviral activity by interacting with coronavirus nucleocapsid proteins across multiple genera and recruiting the E3 ubiquitin ligase MARCHF8 to ubiquitinate them for NDP52/CALCOCO2-dependent selective autophagic degradation (PMID:34612687, PMID:40266995). Knockout mice are viable but show altered growth, survival, and microcytic red blood cell parameters that are not red-cell intrinsic.

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1995 Medium

    Established PABPC4 as a distinct, inducible cytoplasmic poly(A)-binding protein rather than a constitutive housekeeping factor, raising the question of activity-dependent mRNA regulation.

    Evidence Molecular cloning, Northern blot, and subcellular fractionation/immunofluorescence in T cells and tissues

    PMID:8524242

    Open questions at the time
    • No molecular target mRNAs identified at this stage
    • Inducibility mechanism not resolved
  2. 1997 Medium

    Confirmed that the protein binds poly(A) RNA through its four RRM domains, defining its biochemical activity.

    Evidence Expression cloning with monoclonal antibody and poly(A)-Sepharose binding of recombinant protein

    PMID:9030741

    Open questions at the time
    • Surface expression on platelets not mechanistically explained
    • No in-cell RNA targets defined
  3. 2004 Medium

    Showed PABPC4 binds AU-rich RNA nearly as well as poly(A), implying it engages internal mRNA elements and not only the poly(A) tail.

    Evidence Quantitative in vitro RNA-binding affinity measurements with recombinant protein

    PMID:14717712

    Open questions at the time
    • No cellular AU-rich targets identified in this study
    • Functional consequence of AU-rich binding untested
  4. 2005 High

    Defined a translational-enhancer function for PABPC4 on IL-2 mRNA and identified Tob as a C-terminal-binding regulator that switches off this activity.

    Evidence Co-IP in T cells, GST pull-down mapping the C-terminal region, and in vitro translation assays

    PMID:15676026

    Open questions at the time
    • Generality beyond IL-2 mRNA not established
    • Structural basis of Tob/C-terminal interaction unresolved
  5. 2010 Medium

    Linked PABPC4 to posttranscriptional stabilization of hTERT mRNA in HPV16 E6 keratinocytes via the NFX1-123 PAM2 bridge, extending its role to viral oncogenesis.

    Evidence siRNA knockdown, overexpression, qRT-PCR, and telomerase (TRAP) assays

    PMID:20943973

    Open questions at the time
    • Direct PABPC4 binding to hTERT mRNA not shown
    • Redundancy with PABPC1 not dissected
  6. 2014 High

    Demonstrated PABPC4 selectively stabilizes AU-rich erythroid mRNAs when poly(A) tails shorten, with a defined developmental phenotype upon depletion.

    Evidence RNA co-IP, siRNA knockdown, mRNA stability assays, and motif analysis in erythroblasts

    PMID:24469397

    Open questions at the time
    • Mechanism of selective protection at short poly(A) unresolved
    • In vivo erythroid requirement not yet tested at this stage
  7. 2018 Medium

    Connected PABPC4 to cancer stem cell biology via a miR-192-5p/promoter-methylation circuit in hepatocellular carcinoma.

    Evidence miRNA overexpression/suppression, luciferase reporters, and functional CSC assays

    PMID:30530815

    Open questions at the time
    • Molecular events downstream of PABPC4 elevation not resolved
    • Direct PABPC4 mRNA targets in CSCs unknown
  8. 2021 High

    Identified a broad antiviral mechanism whereby PABPC4 bridges coronavirus N proteins to MARCHF8-mediated ubiquitination and NDP52-dependent autophagic degradation.

    Evidence Co-IP across N proteins of eight CoVs, ubiquitination assays, autophagy inhibitor experiments, and viral replication readouts

    PMID:34612687

    Open questions at the time
    • Determinants of N-protein recognition not mapped
    • Whether RNA binding is required for antiviral activity unknown
  9. 2021 Medium

    Showed PABPC4 is itself a regulated substrate of E3 ligases (TRIM25) and that this ubiquitination contributes to antiviral defense against alphaviruses.

    Evidence TRIM25 catalytic-mutant substrate trapping, proteomics, siRNA knockdown, and viral infection assays

    PMID:36067236

    Open questions at the time
    • Functional consequence of PABPC4 ubiquitination on its RNA activity unresolved
    • Ubiquitination sites not mapped
  10. 2021 Medium

    Placed PABPC4 within neuronal translational control as an interactor of LLPS-deficient TDP-43 that contributes to enhanced global protein synthesis.

    Evidence Co-IP from brain tissue, mouse knock-in model, metabolic labeling, and motif-deletion mutants

    PMID:34427634

    Open questions at the time
    • Direct vs indirect PABPC4-TDP-43 contact unclear
    • PABPC4-specific contribution within the multiprotein complex not isolated
  11. 2021 Medium

    Established PABPC4 as a target of multiple regulatory lncRNAs that tune its abundance and downstream mRNA fates in cancer.

    Evidence RNA pulldown, RIP, ubiquitination and mRNA-stability assays for RP11-286H15.1, Lnc-PCIR, and circFAM134B

    PMID:33259899 PMID:34012913 PMID:37603831

    Open questions at the time
    • Whether these lncRNAs share a common PABPC4 interaction surface unknown
    • NMD-antagonist role mechanistically incomplete
  12. 2023 High

    Uncovered a non-RNA-stability role: PABPC4 binds NCoR1 and protects it from degradation, thereby restraining PPAR-driven mitochondrial biogenesis and oxidative metabolism.

    Evidence Co-IP, siRNA knockdown, ubiquitination assays, Seahorse oxygen consumption, and gene-expression analysis in C2C12/MEF cells

    PMID:37059182

    Open questions at the time
    • How an RNA-binding protein stabilizes a corepressor mechanistically unclear
    • In vivo metabolic relevance not tested in this study
  13. 2025 Medium

    Defined PABPC4 (with PABPC1) as required for poly(A)-tail maintenance and global transcriptome buffering during prolonged mitotic arrest.

    Evidence siRNA depletion, poly(A)-tail length profiling, and mRNA half-life measurements (preprint)

    PMID:41641701

    Open questions at the time
    • Relative contributions of PABPC4 vs PABPC1 not separated
    • Preprint, awaits peer review
  14. 2025 Medium

    Showed PABPC4 is required for Pumilio-mediated repression by concentration-dependent protection of poly(A) from CCR4-NOT deadenylation, integrating it into a defined repression pathway.

    Evidence Co-IP with PUM1/2, siRNA knockdown, mRNA stability assays, and transcriptome analysis

    PMID:41641701

    Open questions at the time
    • Direct vs PUM-bridged poly(A) protection not fully resolved
    • Selectivity of PABPC4 vs PABPC1 in this context unclear
  15. 2025 Medium

    Provided in vivo genetic evidence that PABPC4 is non-essential for viability but influences growth, survival, and red-cell parameters non-cell-autonomously.

    Evidence Knockout and conditional mouse genetics with haematological and growth analysis (preprint)

    Open questions at the time
    • Tissue source of the non-intrinsic microcytic phenotype unidentified
    • Preprint, awaits peer review

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PABPC4 achieves transcript selectivity and how its RNA-binding activity is mechanistically coupled to its protein-stabilizing and antiviral functions remain unresolved.
  • No structural model of PABPC4 on selected mRNAs or with NCoR1/N proteins
  • Functional separation of PABPC4 from PABPC1 across contexts incomplete
  • Determinants of AU-rich vs poly(A) target choice in cells unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0045182 translation regulator activity 1 GO:0098772 molecular function regulator activity 1 GO:0140313 molecular sequestering activity 1
Localization
GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-9612973 Autophagy 2
Partners
CALCOCO2MARCHF8NCOR1PABPC1PUM1PUM2TOB1TRIM25

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 iPABP (PABPC4) was identified as an inducible poly(A)-binding protein predominantly localized to the cytoplasm, with expression upregulated following T-cell activation. Unlike constitutively expressed PABP, iPABP mRNA levels are rapidly induced upon T-cell activation and are highly expressed in heart and skeletal muscle tissue. Molecular cloning, Northern blot, subcellular fractionation/immunofluorescence Molecular and cellular biology Medium 8524242
1997 APP-1 (PABPC4) was identified as an activated-platelet protein expressed on the platelet surface upon stimulation by thrombin, A23187, or ADP. Recombinant APP-1 protein specifically binds poly(A)-Sepharose, demonstrating poly(A) RNA-binding activity mediated through four RNA recognition motif domains. Expression cloning with monoclonal antibody, poly(A)-Sepharose binding assay, Northern analysis European journal of biochemistry Medium 9030741
2004 iPABP (PABPC4) binds AU-rich RNA with high affinity and shows less discrimination between AU-rich and poly(A) RNA than PABP1 (affinities differing by only twofold), suggesting PABPC4 may interact with RNA regions beyond the poly(A) tail in cells. In vitro RNA binding affinity measurements (electrophoretic mobility shift / filter binding), recombinant protein European journal of biochemistry Medium 14717712
2005 Tob anti-proliferative protein physically associates with the C-terminal region of iPABP (PABPC4), and this interaction abrogates iPABP-enhanced translation of IL-2 mRNA in vitro. iPABP enhances translation of IL-2 mRNA in a manner requiring the 3'UTR and poly(A) sequences. Tob was co-immunoprecipitated with iPABP in human T cells after anergic stimulation. Co-immunoprecipitation, GST pull-down, in vitro translation assay Genes to cells : devoted to molecular & cellular mechanisms High 15676026
2010 PABPC4 (and PABPC1) are required for the posttranscriptional stabilization of hTERT mRNA and telomerase activity in HPV16 E6-expressing keratinocytes. Overexpression of PABPC4 increased hTERT mRNA levels and telomerase activity, while knockdown decreased them. This effect was dependent on the PAM2 motif of the NFX1-123 co-factor, which bridges HPV16 E6 and PABPCs. Knockdown had no effect in HPV-negative C33A cells. siRNA knockdown, overexpression, qRT-PCR, telomerase activity assay (TRAP) Journal of virology Medium 20943973
2014 PABPC4 is expressed in erythroid cells and stabilizes a subset of erythroid mRNAs containing AU-rich motifs in their 3'UTRs, particularly when poly(A) tails are critically shortened. Selective depletion of PABPC4 in an erythroblast cell line inhibits terminal erythroid maturation with corresponding alterations in erythroid gene expression. RNA co-immunoprecipitation, siRNA knockdown, mRNA stability assays, motif analysis Molecular and cellular biology High 24469397
2018 miR-192-5p suppresses PABPC4 expression, and suppression of miR-192-5p in HCC cells significantly increased PABPC4 levels and multiple cancer stem cell (CSC) populations and CSC-related features. The circuit from hypermethylation of the mir-192 promoter to increased PABPC4 was identified as a shared regulatory pathway in CSC+ HCC. miRNA overexpression/suppression, luciferase reporter, loss-of-function, functional CSC assays Cancer research Medium 30530815
2020 The lncRNA RP11-286H15.1 binds to PABPC4 (nucleotides 620-750) and promotes its ubiquitination, reducing the stability of TRIM37 and CDC27 mRNAs, thereby repressing HCC progression. RNA pulldown, RNA immunoprecipitation (RIP), ubiquitination assay, FISH, Western blot Cancer letters Medium 33259899
2021 PABPC4 broadly inhibits coronavirus replication by interacting with the nucleocapsid (N) protein from eight CoVs across four genera, recruiting E3 ubiquitin ligase MARCH8/MARCHF8 to ubiquitinate the N protein, which is then recognized by cargo receptor NDP52/CALCOCO2 and delivered to autolysosomes for degradation via selective autophagy. Co-immunoprecipitation, overexpression/knockdown, viral replication assays, ubiquitination assay, autophagy inhibitor experiments Microbiology spectrum High 34612687
2021 PABPC4 is identified as a substrate of the E3 ubiquitin ligase TRIM25 by a substrate-trapping approach. Knockdown of PABPC4 diminished TRIM25-mediated antiviral activity against alphaviruses, indicating PABPC4 ubiquitination by TRIM25 contributes to antiviral defense. TRIM25 catalytic mutant (R54P) substrate trapping, proteomics, siRNA knockdown, viral infection assay PLoS pathogens Medium 36067236
2021 TDP-43 LLPS ablation increased its association with PABPC4, RPS6, RPL7, and other translational factors in mouse brain neurons, resulting in globally enhanced protein synthesis. Physical interaction between LLPS-deficient TDP-43 and PABPC4 (along with other translational factors) requires a specific TDP-43 motif, deletion of which abolishes the translational impact. Co-immunoprecipitation, mouse knock-in model, metabolic labeling of protein synthesis, mutant TDP-43 The Journal of cell biology Medium 34427634
2023 PABPC4 interacts with nuclear receptor corepressor NCoR1, and silencing of PABPC4 increases ubiquitination and consequent degradation of NCoR1, leading to derepression of PPAR-regulated genes, increased oxygen consumption, mitochondria content, and reduced lactate production in C2C12 and MEF cells. PABPC4 protein content is markedly reduced under conditions that induce mitochondrial function/biogenesis. Co-immunoprecipitation, siRNA knockdown, ubiquitination assay, Seahorse oxygen consumption, gene expression analysis The Journal of biological chemistry High 37059182
2021 PABPC4 was identified as the most enriched binding partner of circFAM134B via RNA pulldown and mass spectrometry. PABPC4 functions as an antagonist of nonsense-mediated mRNA decay (NMD), and circFAM134B acts as a sponge that competitively sequesters PABPC4, thereby releasing FAM134B mRNA to NMD-mediated decay. RNA pulldown, mass spectrometry, RNA immunoprecipitation (RIP), luciferase reporter, NMD reporter gene assay Cell cycle Medium 37603831
2021 LncRNA Lnc-PCIR blocks PABPC4 proteasome-dependent ubiquitination degradation, and the resulting stabilized PABPC4 increases TAB3 mRNA stability in triple-negative breast cancer cells, activating the TNF-α/NF-κB pathway. RNA pulldown, RIP, Western blot, siRNA knockdown, mRNA stability assay Frontiers in oncology Medium 34012913
2018 PABPC4 interacts with LIX1L (a putative RNA-binding protein) as identified by MALDI-TOF/TOF mass spectrometry and RNA immunoprecipitation-sequencing in HEK-293 cells. Mass spectrometry, RNA immunoprecipitation-sequencing Scientific reports Low 26310847
2021 Sheep SERP1 and PABPC4 were identified as host target proteins of Orf virus ORF047 (L1R) by yeast two-hybrid screening, with interaction confirmed by Co-IP, suggesting PABPC4 involvement in viral mRNA translation and replication. Yeast two-hybrid, Co-immunoprecipitation Virology journal Low 33499896
2024 PABPC4 is identified by RBPmap bioinformatics and functionally confirmed by siRNA depletion to be responsible for repressive activity of the HPV-1a late 3'UTR in keratinocytes, demonstrating a role for PABPC4 in papillomavirus late gene expression regulation. siRNA depletion, reporter gene assay, bioinformatics prediction Biomedical reports Low 39006509
2025 PABPC4 inhibits SADS-CoV replication by targeting and degrading the N protein via selective autophagy. PABPC4 recruits MARCHF8 (E3 ubiquitin ligase) to ubiquitinate the N protein, which is then degraded via NDP52/CALCOCO2 cargo receptor, replicating the mechanism established for other coronaviruses. Co-immunoprecipitation, overexpression/knockdown, ubiquitination assay, viral replication assay Veterinary sciences Medium 40266995
2025 PABPC1 and PABPC4 are required for global mRNA stabilization during prolonged mitotic arrest. Depletion of PABPC1&4 disrupts poly(A)-tail length maintenance during mitosis and compromises the maintenance of mitotic arrest, demonstrating that mitotic transcriptome buffering is PABPC-dependent. siRNA depletion, poly(A)-tail length profiling, mitotic arrest assays, mRNA half-life measurements bioRxiv Medium 41641701
2025 PABPC4 (together with PABPC1) is required for Pumilio (PUM1/2)-mediated mRNA repression. PUMs physically associate with PABPC4, and in its absence, PUM target mRNAs bypass PUM-mediated control. Increasing PABPC concentration inhibits PUM activity in a concentration-dependent manner by protecting poly(A) from CCR4-NOT deadenylation. Co-immunoprecipitation, siRNA knockdown, mRNA stability assays, transcriptome analysis Nucleic acids research Medium 41641701
2025 In Pabpc4 knockout mice, loss of PABPC4 is not lethal but affects birth weight, post-natal growth trajectories, survival, and red blood cell parameters (microcytic RBCs, altered RBC distribution width). The microcytic anemia phenotype is not red blood cell intrinsic, as shown by conditional genetic approaches. Knockout mouse generation, conditional genetics, haematological analysis, growth measurement bioRxivpreprint Medium
2023 PABPC4 binds LINC00493 mRNA and facilitates its transfer to ribosomes for translation of the microprotein SMIM26 in renal cell carcinoma cells. RNA immunoprecipitation (RIP), ribosome fractionation, functional validation EMBO reports Low 37009826

Source papers

Stage 0 corpus · 92 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nature chemical biology 499 25402766
2011 Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 426 21300955
2000 In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin. Drug metabolism and disposition: the biological fate of chemicals 256 10772635
1993 Functional binding of cardiolipin to cytochrome c oxidase. Journal of bioenergetics and biomembranes 227 8389748
1986 Properties of the partially purified tonoplast H+-pumping ATPase from oat roots. The Journal of biological chemistry 116 2867999
2002 Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms. Neurobiology of aging 109 12392798
1995 iPABP, an inducible poly(A)-binding protein detected in activated human T cells. Molecular and cellular biology 74 8524242
2018 miR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features. Cancer research 71 30530815
2005 Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. Genes to cells : devoted to molecular & cellular mechanisms 64 15676026
2004 Human PABP binds AU-rich RNA via RNA-binding domains 3 and 4. European journal of biochemistry 63 14717712
2016 Molecular Mechanisms of Anti-metastatic Activity of Curcumin. Anticancer research 59 27793885
2005 Novel DNA-binding properties of the RNA-binding protein TIAR. Nucleic acids research 58 16091628
2008 Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human. Drug metabolism letters 54 19356090
2004 Catalysis and function of the p38 alpha.MK2a signaling complex. Biochemistry 49 15287722
2019 Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers. International journal of molecular sciences 47 31052292
2003 Leucine-zipper-mediated homo- and hetero-dimerization of GIT family p95-ARF GTPase-activating protein, PIX-, paxillin-interacting proteins 1 and 2. The Biochemical journal 47 12611588
2021 PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy. Microbiology spectrum 44 34612687
2011 Synthesis, characterization, interaction with DNA, and cytotoxic effect in vitro of new mono- and dinuclear Pd(II) and Pt(II) complexes with benzo[d]thiazol-2-amine as the primary ligand. Inorganic chemistry 43 21520903
2014 Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Molecular and cellular biology 39 24469397
2001 Kinetic and mechanistic properties of biotin sulfoxide reductase. Biochemistry 39 11170471
2023 LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma. EMBO reports 37 37009826
2001 Biochemical characterization and expression analysis of the Xenopus laevis corticotropin-releasing hormone binding protein. Molecular and cellular endocrinology 36 11223175
2020 A novel long non-coding RNA RP11-286H15.1 represses hepatocellular carcinoma progression by promoting ubiquitination of PABPC4. Cancer letters 35 33259899
2001 A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. Genomics 35 11374897
2022 Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes. PLoS pathogens 34 36067236
2010 Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes. Journal of virology 33 20943973
2022 Synthesis, Characterization, Crystal Structure, DNA and HSA Interactions, and Anticancer Activity of a Mononuclear Cu(II) Complex with a Schiff Base Ligand Containing a Thiadiazoline Moiety. ACS omega 31 35097283
2000 Modification of in vitro drug release rate from oily parenteral depots using a formulation approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 31 11042229
2017 Human barrier models for the in vitro assessment of drug delivery. Drug delivery and translational research 30 27549106
2021 Translational regulation in the brain by TDP-43 phase separation. The Journal of cell biology 29 34427634
1997 Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets. European journal of biochemistry 26 9030741
2006 Design, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structures. Journal of medicinal chemistry 25 16913707
2014 Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway. Biochemical and biophysical research communications 24 24727450
2020 Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo. The EMBO journal 21 33231880
2004 Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells. European journal of nutrition 20 15316828
2006 The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseases. RNA (New York, N.Y.) 19 16714280
2018 Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors. European journal of medicinal chemistry 18 30611982
2013 Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success. Molecular & cellular proteomics : MCP 18 23938467
2010 Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation. European journal of pharmacology 18 20883690
2023 Transcriptome-wide association study-derived genes as potential visceral adipose tissue-specific targets for type 2 diabetes. Diabetologia 16 37540242
2023 circFAM134B is a key factor regulating reticulophagy-mediated ferroptosis in hepatocellular carcinoma. Cell cycle (Georgetown, Tex.) 16 37603831
2021 Gene variants of coagulation related proteins that interact with SARS-CoV-2. PLoS computational biology 16 33730015
2019 The Molecular Misreading of APP and UBB Induces a Humoral Immune Response in Alzheimer's Disease Patients with Diagnostic Ability. Molecular neurobiology 16 31654319
2010 Misframed proteins and neurodegeneration: a novel view on Alzheimer's and Parkinson's diseases. Neuro-degenerative diseases 15 20173331
2003 Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology. The Journal of biological chemistry 15 12900421
2022 Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 14 35006347
2022 Mixed Ligand Mononuclear Copper(II) Complex as a Promising Anticancer Agent: Interaction Studies with DNA/HSA, Molecular Docking, and In Vitro Cytotoxicity Studies. ACS omega 14 35785271
2015 Studies on the purification of polypeptide from sika antler plate and activities of antitumor. BMC complementary and alternative medicine 14 26383170
2019 Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy. Molecules (Basel, Switzerland) 13 30641935
2019 Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. The Journal of biological chemistry 13 31292192
2018 Strap associates with Csde1 and affects expression of select Csde1-bound transcripts. PloS one 11 30138317
2012 Immunohistochemical analysis of medullary breast carcinoma autoantigens in different histological types of breast carcinomas. Diagnostic pathology 11 23181716
2004 Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40. Journal of neurochemistry 11 15255950
2000 Molecular misreading. A new type of transcript mutation in gerontology. Annals of the New York Academy of Sciences 11 10911966
2017 18F-Labeled Pyrido[3,4-d]pyrimidine as an Effective Probe for Imaging of L858R Mutant Epidermal Growth Factor Receptor. ACS medicinal chemistry letters 10 28435529
2015 Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation. Scientific reports 10 26310847
1999 Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. Human genetics 10 10543404
2024 Sialic Acid-Targeted Ru(II)/Ir(III)/Re(I) Complexes for Ferroptosis Induction in Triple-Negative Breast Cancer. Langmuir : the ACS journal of surfaces and colloids 9 39556719
2023 Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression. International journal of molecular sciences 8 37511575
2021 Identification and screening of host proteins interacting with ORFV-ORF047 protein. Virology journal 8 33499896
2021 LncRNA PCIR Is an Oncogenic Driver via Strengthen the Binding of TAB3 and PABPC4 in Triple Negative Breast Cancer. Frontiers in oncology 8 34012913
2020 Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorganic & medicinal chemistry 8 32631562
2019 Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide. Drug metabolism and disposition: the biological fate of chemicals 8 30602435
1999 Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration. Journal of neural transmission. Supplementum 8 10666673
1983 Reaction of muscimol with 4-aminobutyrate aminotransferase. Journal of neurochemistry 8 6644308
2024 Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers. PLoS genetics 7 39325823
2023 Mechanism of Intestinal Epithelial Absorption and Electrophysiological Regulation of the Shrimp Peptide QMDDQ. Journal of agricultural and food chemistry 7 38155399
2005 Alzheimer-associated APP+1 transgenic mice: frameshift beta-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology. Neurobiology of aging 7 16214267
2023 Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. The Journal of biological chemistry 6 37059182
2007 Synthesis, and DNA-binding and DNA-photocleavage properties of multiply charged porphyrins. Chemistry & biodiversity 6 17372954
2023 Genome-wide search identified DNA methylation sites that regulate the metabolome. Frontiers in genetics 5 37274792
2023 Multiple RNA-binding proteins associated with long interspersed element-1 encoded ORF1p are targeted by the autoimmune response in systemic lupus erythematosus. Journal of cellular and molecular immunology 5 39606792
2022 Discovery of 3'-O-β-Glucosyltubercidin and the Nucleoside Specific Glycosyltransferase AvpGT through Genome Mining. ACS chemical biology 5 36356213
2015 Gender-specific association between the cytoplasmic poly(A) binding protein 4 rs4660293 single nucleotide polymorphism and serum lipid levels. Molecular medicine reports 5 26005159
2001 A dinucleotide deletion in amyloid precursor protein (APP) mRNA associated with sporadic Alzheimer's disease results in efficient secretion of truncated APP isoforms from neuroblastoma cell cultures. Journal of neurochemistry 5 11238715
2024 Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment. ACS bio & med chem Au 4 39990949
2025 PABPC4 Inhibits SADS-CoV Replication by Degrading the Nucleocapsid Protein Through Selective Autophagy. Veterinary sciences 3 40266995
2024 Identification of coagulation diagnostic biomarkers related to the severity of spinal cord injury. International immunopharmacology 3 38908081
2022 Proline-specific aminopeptidase P prevents replication-associated genome instability. PLoS genetics 3 35081133
2022 Interplay between β-Diimino and β-Diketiminato Ligands in Nickel Complexes Active in the Proton Reduction Reaction. Inorganic chemistry 3 36196853
2024 Alternative Polyadenylation Regulatory Factors Signature for Survival Prediction in Kidney Renal Cell Carcinoma. Cancer informatics 2 38617569
2023 The Effect of an Adapted Digital Mental Health Intervention for Sickle Cell Disease on Engagement: A Pilot Randomized Controlled Trial. Research square 2 37461733
2026 Cytoplasmic poly-adenosine binding proteins modulate susceptibility of mRNAs to Pumilio-mediated decay. Nucleic acids research 1 41641701
2025 Elevated PABPC4 expression in human prostate cancer tissues predicts adverse clinical outcomes. Translational andrology and urology 1 40800098
2021 The long non-coding RNA MEG3 plays critical roles in the pathogenesis of cholesterol gallstone. PeerJ 1 33665015
2007 Differential enrichment of simple sequence repeats in selected Alzheimer-associated genes. Cellular and molecular biology (Noisy-le-Grand, France) 1 17531157
2026 Association of post-transcriptional regulatory gene single nucleotide polymorphisms with Alzheimer's disease. Journal of Alzheimer's disease : JAD 0 41761645
2026 Unveiling muscle fatigue: identifying key gene biomarkers and therapeutic targets. Molecular and cellular biochemistry 0 42183984
2025 Novel non-synonymous and synonymous gene variants of SRD5A2 in patients with 46,XY-DSD and DSD-free subjects. PloS one 0 40043094
2025 Cytoplasmic poly-adenosine binding proteins modulate susceptibility of mRNAs to RNA-binding protein-directed decay. bioRxiv : the preprint server for biology 0 41256622
2024 Identifying regulatory elements and their RNA-binding proteins in the 3' untranslated regions of papillomavirus late mRNAs. Biomedical reports 0 39006509
1998 The effects of reverse micelles on the reaction mechanism of alpha-chymotrypsin. Cancer biochemistry biophysics 0 9925285

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