Affinage

NUPR1

Nuclear protein 1 · UniProt O60356

Length
82 aa
Mass
8.9 kDa
Annotated
2026-06-10
100 papers in source corpus 44 papers cited in narrative 44 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NUPR1 is a small, intrinsically disordered, stress-inducible nuclear factor that acts as a transcriptional coregulator and chromatin-associated hub coordinating cell survival under genotoxic, metabolic, and ER stress (PMID:33510144, PMID:30451898). A central output of NUPR1 is protection against regulated cell death: it transcriptionally upregulates the iron-handling genes LCN2 (limiting iron accumulation and oxidative damage) and FTH1 (enhancing iron storage) to confer ferroptosis resistance (PMID:33510144, PMID:38802795), and it binds and inhibits PARP1 in the nucleus to prevent hyperPARylation-driven, non-canonical Parthanatos and mitochondrial catastrophe (PMID:35869257). NUPR1 also sustains autophagic and lysosomal homeostasis, transcriptionally inducing the SNARE protein SNAP25 that complexes with VAMP8 to maintain autolysosomal efflux (PMID:29130426) and activating TFE3 to preserve autophagic flux (PMID:35462576). Mechanistically, NUPR1 engages partners through a conserved disordered ('fuzzy') hydrophobic hot spot around Ala33, which mediates low-micromolar binding to chromatin and repair-associated factors including MSL1, RING1B, PADI4, and PKP1 (PMID:24205110, PMID:28720707, PMID:36858171, PMID:33385445), while phosphorylation of Thr68 within its nuclear localization signal triggers a conformational switch that disrupts importin α3 binding and gates its nuclear translocation (PMID:32933064, PMID:30920390). In the nucleus NUPR1 stimulates SUMOylation of DNA damage response proteins (PMID:32780723), cooperates with p53/p300 to drive p21 transcription (PMID:18690848), and regulates DNMT1-dependent DNA methylation to modulate oncogene-induced senescence (PMID:24902898, PMID:26617245). Its disordered nature also enables liquid-liquid phase separation required for stress granule formation in KrasG12D-driven pancreatic cancer (PMID:38360999). Through these activities NUPR1 broadly supports tumor cell survival, lipogenesis via SREBP1 (PMID:36307402), and EMT, and it is the pharmacological target of the inhibitor ZZW-115, which blocks its nuclear import and triggers death of cancer cells (PMID:30920390, PMID:35869257).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2008 Medium

    Established NUPR1 as a developmental transcriptional regulator in vivo and as a chromatin-associated partner of p53/p300, framing it as a stress-responsive transcriptional coregulator rather than a passive marker.

    Evidence Nupr1-/- mouse gonadal development phenotyping; Co-IP, p21-promoter ChIP and chemoresistance assays in cancer cells

    PMID:18495683 PMID:18690848

    Open questions at the time
    • Direct DNA-binding versus adaptor role on the p21 promoter not resolved
    • Structural basis of the p53/p300 complex undefined
  2. 2009 Medium

    Identified MSL1 as a NUPR1 partner and placed NUPR1 as a negative regulator of MSL1/53BP1-dependent DNA repair, linking it to the genotoxic stress response.

    Evidence Protein interaction assays, cell-based DNA repair assays after gamma-irradiation, 53BP1 knockdown

    PMID:19650074

    Open questions at the time
    • Binding interface not mapped at this stage
    • Mechanism of repair inhibition unresolved
  3. 2012 Medium

    Connected NUPR1 to metabolic and DNA-methylation control of cell fate, showing it protects against metabolic-stress death via AURKA and chemoresistance via PI3K/Akt-phospho-p21, and is itself a TGFβ/SMAD transcriptional target.

    Evidence Transcriptome profiling, RNAi/overexpression, subcellular fractionation of p21, Akt-inhibitor experiments, SMAD ChIP and 5'-UTR reporter assays

    PMID:22738338 PMID:22858377 PMID:22899799

    Open questions at the time
    • Direct versus indirect regulation of AURKA unclear
    • How NUPR1 couples to Akt mechanistically not defined
  4. 2013 High

    Provided the first quantitative biophysical view of NUPR1, showing it binds MSL1 and damaged DNA through a disordered 'fuzzy' interface, defining its mode of action as an intrinsically disordered interaction hub.

    Evidence ITC, fluorescence, NMR with in-nucleus Co-IP and cisplatin survival assays; promoter reporter assays for Ccna2/Tcf19 in beta cells

    PMID:23900510 PMID:24205110

    Open questions at the time
    • Structure of the bound state not solved (remains disordered)
    • Generality of the fuzzy mode across partners not yet shown at this point
  5. 2015 Medium

    Extended NUPR1's role to oncogene-induced senescence and tumor invasion, showing DNMT1/DNA-methylation control of Kras-driven senescence and Ca2+-dependent regulation of invasion via granulin.

    Evidence Nupr1-/- KrasG12D mouse models, methylation analysis, 5-aza treatment; invasion assays with Ca2+ signaling inhibition and granulin promoter binding

    PMID:24902898 PMID:26173068 PMID:26617245

    Open questions at the time
    • Direct DNMT1 promoter occupancy not established
    • Mechanism linking NUPR1 to Ca2+ signaling undefined
  6. 2017 High

    Mapped the NUPR1 interaction hot spot to the Ala33 hydrophobic patch (RING1B binding) and defined a transcriptional autophagy mechanism (SNAP25/VAMP8), unifying its structural mode with a concrete cell-biological output.

    Evidence NMR mapping, ITC, Ala33Gln mutagenesis, in cellulo ligation assays for RING1B; RNAi, Co-IP of SNAP25/VAMP8 and autophagy flux assays

    PMID:28720707 PMID:29130426

    Open questions at the time
    • Whether the same hot spot mediates all partner interactions not yet generalized
    • Transcriptional versus non-transcriptional contribution to autolysosomal efflux not fully separated
  7. 2018 High

    Demonstrated that NUPR1 loss causes mitochondrial failure and ER-stress-dependent programmed necrosis, establishing NUPR1 as a guardian of mitochondrial integrity during ER stress.

    Evidence Knockdown with mitochondrial membrane potential/OXPHOS/ROS assays, mitochondria-ER imaging, ER-stress inducers, acute pancreatitis model, Nec-1/Z-VAD rescue

    PMID:30451898

    Open questions at the time
    • Molecular link between NUPR1 and mitochondrial maintenance not identified
    • Transcriptional targets driving ER-stress resolution incomplete
  8. 2019 High

    Identified ZZW-115 as a NUPR1 inhibitor that binds the Thr68/NLS region and blocks importin-mediated nuclear import, providing a druggable mechanism and a tool to dissect nuclear functions.

    Evidence ITC/fluorescence binding, modeling, nuclear translocation and necroptosis assays, xenografts; helical-peptide inhibitors of NUPR1-RING1B with Thr68Gln mutants

    PMID:29530795 PMID:30920390

    Open questions at the time
    • Off-target effects of ZZW-115 not fully excluded
    • Which downstream functions are import-dependent not delineated
  9. 2020 High

    Resolved the import-gating mechanism at residue level — Thr68 phosphorylation drives a coil-to-turn switch impairing importin α3 binding — and revealed NUPR1 directly stimulates SUMOylation of DDR proteins, defining a biochemical nuclear activity.

    Evidence NMR conformational analysis, ITC of NLS-Impα3, phospho-mimetic mutants; interactome MS, cell-free SUMOylation reconstitution with recombinant NUPR1; PKP1 binding by NMR/ITC/PLA

    PMID:32780723 PMID:32933064 PMID:33385445

    Open questions at the time
    • Kinase responsible for Thr68 phosphorylation not identified
    • Mechanism by which NUPR1 stimulates the SUMO machinery unresolved
  10. 2021 High

    Consolidated NUPR1 as a master suppressor of regulated cell death, showing it inhibits PARP1 to block Parthanatos and transcriptionally controls LCN2/FTH1 iron handling to confer ferroptosis resistance.

    Evidence Proteomic interactome, NUPR1-PARP1 Co-IP and in vitro PARP1 activity assays with mutants, olaparib/NMN rescue; NanoString/shRNA/conditional KO and LCN2 re-expression; FTH1 promoter ChIP; TFAM-rescue ferroptosis assays

    PMID:33510144 PMID:34599149 PMID:35869257 PMID:38802795

    Open questions at the time
    • Stoichiometry/site of PARP1 inhibition not structurally defined
    • How NUPR1 selects between ferroptosis, Parthanatos and necrosis outputs unclear
  11. 2022 Medium

    Broadened NUPR1's regulatory reach to lipogenesis, autophagy and UPR resolution, and to additional chromatin partners, positioning it as an integrator of metabolic and proteostatic stress.

    Evidence SREBP1 Co-IP and FASN/lipid assays; TFE3 activity and autophagy assays; AhR Co-IP and autophagic degradation; eIF2α Co-IP/PLA and nascent-synthesis assays; PPAR-α/UPR analysis in KO mice

    PMID:33403797 PMID:33566371 PMID:35462576 PMID:36258210 PMID:36307402

    Open questions at the time
    • Direct versus indirect engagement of each metabolic partner varies in rigor
    • Whether these interactions share the Ala33 hot spot not tested for all partners
  12. 2023 Medium

    Generalized the Ala33 hydrophobic-patch binding mode to PADI4 and detailed transcriptional/epigenetic control of NUPR1 itself, including SETD4-mediated H3K27me3 repression and m6A-dependent stabilization.

    Evidence NMR/ITC/PLA for PADI4 with Ala33 mutagenesis; SETD4 ChIP for H3K27me3 at the NUPR1 locus; WTAP/eIF3A m6A and mRNA-stability assays

    PMID:36858171 PMID:37477758 PMID:37879429

    Open questions at the time
    • Functional consequence of NUPR1-PADI4 binding not established
    • Interplay between epigenetic and post-transcriptional control of NUPR1 levels unresolved
  13. 2024 High

    Showed NUPR1 undergoes liquid-liquid phase separation required for stress granule formation in KrasG12D pancreatic cancer, providing a biophysical basis for its disordered-protein stress functions.

    Evidence In vitro LLPS assays, stress granule imaging, ZZW-115 inhibition, NUPR1 overexpression, KC mouse model with caspase-3 readouts

    PMID:38360999

    Open questions at the time
    • Partner RNAs/proteins co-condensing with NUPR1 not identified
    • Link between LLPS and the transcriptional/chromatin functions not resolved
  14. 2025 Medium

    Embedded NUPR1 in the tumor microenvironment and stress-hormone signaling, showing lactate/histone-lactylation induces it in macrophages to promote M2 polarization and that glucocorticoid-receptor signaling drives NUPR1-dependent EMT.

    Evidence scRNA-seq, histone-lactylation analysis and ERK/JNK assays in macrophages; NR3C1 promoter regulation and SNAI2/EMT in stress mouse models; FTO/YTHDF2 m6A stabilization of NUPR1 mRNA

    PMID:40305758 PMID:40334546 PMID:40654365

    Open questions at the time
    • Cell-intrinsic versus microenvironmental contributions not separated
    • Mechanism by which NUPR1 suppresses ERK/JNK undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NUPR1's disordered structure, Thr68-gated nuclear import, phase separation, and partner-selection at the Ala33 hot spot are integrated to choose among its many context-specific outputs (ferroptosis, Parthanatos, autophagy, lipogenesis, EMT) remains unresolved.
  • No structural model of NUPR1 in any partner complex (interface remains 'fuzzy')
  • Upstream kinase and signaling that control Thr68 phosphorylation unknown
  • Determinants of partner/output selection from a single hydrophobic hot spot undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0140110 transcription regulator activity 4 GO:0003677 DNA binding 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005634 nucleus 7 GO:0005829 cytosol 2
Pathway
R-HSA-5357801 Programmed Cell Death 4 R-HSA-73894 DNA Repair 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-8953897 Cellular responses to stimuli 3 R-HSA-9612973 Autophagy 3
Partners
AHREIF2S1MSL1PADI4PARP1PKP1RING1BSREBP1

Evidence

Reading pass · 44 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2021 NUPR1 drives ferroptosis resistance by transcriptionally upregulating LCN2, which reduces iron accumulation and subsequent oxidative damage. LCN2 depletion mimics NUPR1 deficiency with respect to ferroptosis induction, and re-expression of LCN2 restores ferroptosis resistance in NUPR1-deficient cells. NanoString gene expression, shRNA knockdown (NUPR1 and LCN2), pancreas-specific conditional knockout mice, enforced LCN2 re-expression, ferroptosis induction assays with erastin, mouse models of pancreatitis Nature communications High 33510144
2017 NUPR1 maintains autolysosomal efflux by transcriptionally inducing the SNARE protein SNAP25, which forms a complex with the lysosomal SNARE-associated protein VAMP8. NUPR1 depletion impairs autophagic flux and induces massive cytoplasmic vacuolization and premature senescence. NUPR1 depletion (RNAi), transcriptional induction assays, co-immunoprecipitation of SNAP25/VAMP8 complex, autophagy flux assays, senescence assays in vitro and tumor suppression in vivo Autophagy High 29130426
2008 NUPR1 forms a complex with p53 and p300 and binds the p21 promoter to transcriptionally upregulate p21 expression, conferring resistance to doxorubicin and Taxol. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP) on p21 promoter, reporter assays, doxorubicin/Taxol resistance assays Current cancer drug targets Medium 18690848
2009 NUPR1 (p8) binds MSL1, a histone acetyltransferase (HAT)-associated protein, and negatively regulates MSL1-dependent DNA repair activity following gamma-irradiation. MSL1 binds the DNA-damage-associated protein 53BP1 to facilitate DNA repair, and p8 interaction inhibits this repair activity. NUPR1 expression is transiently induced then downregulated after irradiation, presumably to allow MSL1-associated DNA repair to proceed. Protein-protein interaction assays, cell-based DNA repair assays, gamma-irradiation, 53BP1 knockdown experiments Journal of cellular physiology Medium 19650074
2013 Nupr1 and MSL1 form a complex in the nucleus in response to DNA damage, essential for cell survival in response to cisplatin. MSL1 binds Nupr1 with an affinity of ~2.8 µM (entropically driven), and MSL1 binds chemically damaged DNA with ~1.2 µM affinity. The binding region of Nupr1 in its complexes is always disordered ('fuzzy'). Spectroscopic and biophysical methods (fluorescence, ITC, NMR), Co-IP in nucleus, cisplatin survival assays PloS one High 24205110
2017 NUPR1 binds the C-terminal region of Polycomb RING1B (C-RING1B) with affinity in the low micromolar range (~10 µM). The binding region of NUPR1 was mapped by NMR to a hydrophobic patch at the 30s region (around Ala33). Mutation of Ala33 to Gln reduces binding. This interaction is inhibited by trifluoperazine and occurs in cellulo (by protein ligation assays). NMR, computational docking, isothermal titration calorimetry, site-directed mutagenesis (Ala33Gln, Thr68Gln), protein ligation assays in cellulo Proceedings of the National Academy of Sciences of the United States of America High 28720707
2019 ZZW-115 (a TFP-derived compound) binds NUPR1 around residue Thr68 in the nuclear localization signal (NLS) region, competing with importins and thereby completely inhibiting nuclear translocation of NUPR1. This mechanism underlies its anticancer (necroptosis-inducing) activity. Biophysical binding assays (ITC, fluorescence), computer modeling, nuclear translocation assays, cell death mechanistic assays (necroptosis markers), xenograft tumor models The Journal of clinical investigation High 30920390
2020 NUPR1 interacts with several hundreds of proteins including importins, DNA repair proteins, and key SUMO pathway factors. ZZW-115 competes with importins for binding to the NLS region of NUPR1, inhibiting nuclear translocation. NUPR1 inhibition reduces SUMOylation of DNA damage response (DDR) proteins; recombinant NUPR1 directly stimulates the SUMOylation machinery in a cell-free system. Interactome mass spectrometry, nuclear translocation assays, SUMOylation assays in cells and cell-free system with recombinant NUPR1, genotoxic agent sensitization assays JCI insight High 32780723
2012 NUPR1 confers chemoresistance in p53-deficient breast cancer cells by promoting Akt-mediated phosphorylation and subsequent cytoplasmic re-localization of p21 and activation of anti-apoptotic Bcl-xL, defining a NUPR1-PI3K/Akt-phospho-p21 axis. NUPR1 knockdown/overexpression, p21 localization by immunofluorescence/fractionation, Akt inhibitor experiments, chemoresistance assays FEBS letters Medium 22858377
2012 Nupr1 protects pancreatic cancer cells from metabolic stress-induced autophagy-associated cell death through regulation of Aurora kinase A (AURKA). Nupr1 knockdown enhances DNA damage, alters gene expression related to DNA repair and cell cycle, and AURKA expression is partially regulated by Nupr1. Affymetrix transcriptome analysis, RNAi silencing, AURKA overexpression, DNA damage markers (Western blot and immunofluorescence), autophagy markers, human TMA analysis Clinical cancer research Medium 22899799
2018 Inactivation of NUPR1 induces mitochondrial failure (loss of membrane potential, increased ROS, decreased OXPHOS/ATP production), relocalization of mitochondria near the ER, and downregulation of ER stress response genes, leading to programmed necrosis (reversed by Necrostatin-1 but not Z-VAD-FMK). In vivo, NUPR1 protects acinar cells from necrosis during ER stress in acute pancreatitis. NUPR1 knockdown, mitochondrial membrane potential assays, OXPHOS/ATP measurement, ROS measurement, mitochondria/ER co-localization imaging, transcriptomic analysis, thapsigargin/brefeldin A/tunicamycin treatment, acute pancreatitis mouse model, Necrostatin-1 and Z-VAD-FMK rescue experiments Scientific reports High 30451898
2021 NUPR1 binds PARP1 in the nucleus and inhibits PARP1 activity in vitro. Inhibition of NUPR1 (genetically or by ZZW-115) induces hyperPARylation, mitochondrial catastrophe (decreased membrane potential, superoxide production, increased ROS, cytosolic Ca2+ elevation), and cell death through non-canonical Parthanatos (without AIF translocation from mitochondria). This is rescued by PARP inhibitor olaparib or NAD+ precursor NMN. Proteomic interactome, Co-IP (NUPR1-PARP1), in vitro PARP1 activity assay with recombinant NUPR1 and NUPR1 mutants, PARylation assays, mitochondrial function assays, olaparib rescue, NAD+/NADH ratio measurement Communications biology High 35869257
2021 NUPR1 inhibitor ZZW-115 induces ROS accumulation and ferroptotic cell death in a mitochondria-dependent manner. ZZW-115 causes loss of GSH/GPX antioxidant activity, hydroperoxided lipid accumulation, and mitochondrial morphological changes. TFAM (key regulator of mitochondrial biogenesis) is downregulated by ZZW-115, and forced TFAM expression rescues mitochondrial alterations, ROS production, and cell death. ROS assays, lipid peroxidation assays, ferroptosis inhibitor (ferrostatin-1) rescue, GSH/GPX activity assays, mitochondrial morphology imaging, TFAM overexpression rescue, xenograft models Cell death discovery High 34599149
2012 NUPR1 transcriptionally regulates DNMT1 expression to modulate genome-wide DNA methylation levels, thereby acting as a gene modifier of Kras(G12D)-induced senescence. Nupr1 inactivation in mice leads to increased β-galactosidase-positive cells and upregulation of senescence marker genes via the FoxO3a-Skp2-p27(Kip1)-pRb-E2F pathway. Nupr1 genetic knockout in KrasG12D mice, β-galactosidase senescence assays, gene expression analysis, DNMT1 expression assays, 5-aza-2'-deoxycytidine treatment, RNAi in human pancreatic cancer cells Cell death and differentiation Medium 24902898
2015 Nupr1 acts as a gene modifier of Kras(G12D)-induced senescence by regulating Dnmt1 expression and genome-wide DNA methylation levels, preventing senescence in lung and pancreatic cells to allow transformation. Nupr1-/- mouse models with KrasG12D in pancreas and lung, DNA methylation analysis, DNMT1 expression, senescence assays, 5-aza-2'-deoxycytidine treatment Scientific reports Medium 26617245
2012 NUPR1 transcriptionally regulates human NUPR1 expression is activated by TGFβ at the transcriptional level through SMAD proteins binding to a functional TGFβ-response element located in the 5'-UTR of the NUPR1 gene. Promoter-reporter assays, SMAD ChIP, 5'-UTR deletion/mutation analysis, TGFβ treatment experiments The Biochemical journal Medium 22738338
2016 NUPR1 overexpression decreases levels of the histone acetyltransferase MOF (KAT8) and H4K16 acetylation. Cr(VI)-induced reduction of H4K16 acetylation is substantially compromised by NUPR1 knockdown, indicating NUPR1 mediates the Cr(VI)-induced loss of this cancer-associated epigenetic mark. NUPR1 overexpression and knockdown, H4K16ac Western blot, MOF expression assays, Cr(VI) treatment, anchorage-independent growth assays, cell transformation assays PloS one Medium 27285315
2020 Phosphorylation of Thr68 in the NLS region of NUPR1 induces a conformational switch from random-coil to a turn-like structure, which hampers binding to importin α3 (Impα3). Positive charges at Lys65 and Lys69 are critical for importin binding. The NLS region of NUPR1 binds Impα3 with low micromolar affinity (1.7–27 µM depending on mutant). 2D-1H-NMR (NOE analysis), fluorescence spectroscopy, ITC, molecular docking, phospho-mimetic and alanine mutants of NLS peptides Biomolecules High 32933064
2021 NUPR1 interacts with eIF2α and its phosphorylated form (p-eIF2α) in the nucleus. Loss of NUPR1 results in maintained eIF2α phosphorylation and slower post-stress protein synthesis recovery, implicating NUPR1 in resolution of the PERK branch of the unfolded protein response. Co-immunoprecipitation, proximity ligation assays (PLA), bioinformatic analysis of interactome, click chemistry for nascent protein synthesis, NUPR1 knockout mouse pancreatic acinar cells The FEBS journal Medium 33403797
2022 NUPR1 interacts with aryl hydrocarbon receptor (AhR) and promotes its degradation via the autophagy-lysosome pathway and decreased nuclear translocation, thereby suppressing CYP transcription. This reduces ROS production and confers radioresistance in hepatocellular carcinoma. Co-immunoprecipitation, RNA sequencing, AhR nuclear translocation assays, pharmacological AhR activation, lysosome inhibition assays, xenograft models, NUPR1 knockdown BMC medicine Medium 36258210
2022 NUPR1 promotes proliferation and metastasis in oral squamous cell carcinoma by directly increasing TFE3 transcription factor activity, thereby maintaining autophagic flux and lysosomal function. Tandem mass tag quantitative proteomics, NUPR1 stable knockdown, TFE3 activity assays, autophagy flux assays, in vitro and in vivo tumor growth and metastasis models Signal transduction and targeted therapy Medium 35462576
2024 NUPR1 induces droplet formation via liquid-liquid phase separation (LLPS) and is required for stress granule (SG) formation in pancreatic cancer cells. KrasG12D mutation induces NUPR1 overexpression and promotes SG development; enforced NUPR1 expression alone induces SG formation independently of KrasG12D. Inhibition of NUPR1 by ZZW-115 impedes SG formation and selectively kills KrasG12D-expressing cells via caspase 3 activation. LLPS assays, stress granule imaging, ZZW-115 pharmacological inhibition, NUPR1 genetic overexpression, KrasG12D mouse model (KC mice), caspase 3 activation, LDH release, PanIN analysis in vivo EMBO molecular medicine High 38360999
2023 NUPR1 binds PADI4 (peptidyl-arginine deiminase 4) mainly in the nucleus, with a dissociation constant of ~18 µM. The binding region of NUPR1 involves the hydrophobic patch around Ala33 (mapped by NMR and confirmed by Ala33 mutagenesis). NMR (binding region mapping), ITC (affinity measurement), site-directed mutagenesis (Ala33), proximity ligation assays (PLA) in cellulo, immunofluorescence, molecular modelling Journal of molecular biology High 36858171
2020 NUPR1 binds PKP1 (Plakophilin 1) at the armadillo-repeat domain with ~10 µM affinity; the binding region of NUPR1 is the 30s region (around Ala33). This interaction occurs in the nucleus as confirmed by proximity ligation assays. Fluorescence spectroscopy, NMR, molecular docking, isothermal titration calorimetry, protein ligation assays in cellulo, immunofluorescence International journal of biological macromolecules Medium 33385445
2021 Nupr1 mediates TGF-β-induced myofibroblast activation (α-SMA expression, collagen synthesis) by initiating the Smad3 signaling pathway in kidney fibroblasts and epithelial cells undergoing EMT. Nupr1 deficiency attenuates UUO-induced renal fibrosis in mice, and TFP (NUPR1 inhibitor) alleviates fibrosis. Nupr1-/- mice with UUO model, TGF-β stimulation of primary fibroblasts and epithelial cells, Smad3 phosphorylation assays, α-SMA/collagen expression, TFP pharmacological inhibition FASEB journal Medium 33617091
2016 NUPR1 silencing in HCC cells reduced expression of RELB, IER3, and RUNX2 genes and downregulated NF-κB and ERK signaling nodes, demonstrating a NUPR1/RELB/IER3/RUNX2 regulatory pathway in hepatocarcinogenesis. NUPR1 stable knockdown, gene expression profiling (microarray), RELB/IER3/RUNX2 knockdown experiments, cell growth/migration/invasion assays, sorafenib sensitivity assays Cell death & disease Medium 27336713
2013 NUPR1 promotes cell cycle progression in pancreatic beta cells by suppressing Ccna2 and Tcf19 promoter activities. Nupr1 deletion increases beta cell mass through enhanced islet cell proliferation. Nupr1-/- mice, BrdU incorporation for proliferation, luciferase promoter reporter assays for Ccna2 and Tcf19, gene arrays, morphometric analysis of islets Diabetologia Medium 23900510
2015 NUPR1 knockdown in liver cancer cells suppressed invasion in a Ca2+-signaling-dependent manner. NUPR1 promoter binding assay identified granulin as a key downstream effector of NUPR1 in a mitochondrial defect-related pathway. NUPR1 knockdown, invasion assays, Ca2+ signaling inhibition, NUPR1-centric network analysis, promoter binding assay for granulin Hepatology Medium 26173068
2022 NUPR1 interacts with SREBP1 and upregulates lipogenic gene expression (FASN), resulting in lipid accumulation that promotes hepatocellular carcinoma progression. Pharmacological or genetic blockade of the NUPR1-SREBP1/FASN pathway reduces tumor growth in vitro and in vivo. Co-immunoprecipitation (endogenous NUPR1-SREBP1), FASN and lipid accumulation assays, NUPR1 knockdown/overexpression, xenograft tumor models Cell death discovery Medium 36307402
2022 NUPR1 promotes proliferation and metastasis in breast cancer by activating TFE3 transcription, thereby inducing autophagy. NUPR1 knockdown inhibits malignancy formation and metastasis in vivo. NUPR1 knockdown, TFE3 transcription assays, autophagy marker analysis, breast cancer in vitro and xenograft in vivo models Experimental cell research Low 35660538
2016 Nupr1 in the METH-exposure context acts upstream of the CHOP-P53-PUMA/Beclin1 pathway to induce mitochondrial apoptosis in endothelial cells. CHOP upregulation by Nupr1 leads to Beclin1 induction, which forms a ternary complex with Bcl-2 to reduce free Bcl-2 and promote cytochrome c release and caspase activation. shRNA/siRNA silencing of Nupr1, CHOP, P53, PUMA, Beclin1; Western blot for pathway markers; apoptosis assays; cytochrome c translocation assay; in vitro and in vivo (rat) models Cell death & disease Medium 27031958
2023 SETD4 methyltransferase represses NUPR1 transcription by catalyzing H3K27 trimethylation (H3K27me3) at the NUPR1 locus, thereby inactivating the Akt pathway and suppressing prostate cancer development. SETD4 knockdown/overexpression, H3K27me3 ChIP, NUPR1 expression assays, Akt pathway analysis, prostate cancer cell proliferation and cell cycle assays Cancer letters Medium 37879429
2022 Loss of Nupr1 in hematopoietic stem cells (HSCs) activates quiescent HSCs and confers engraftment advantage. Nupr1 inhibits p53 expression in HSCs; rescue of p53 offsets the engraftment advantage of Nupr1-/- HSCs, placing Nupr1 upstream of p53 in HSC quiescence regulation. Nupr1 conditional knockout, serial transplantation assays, p53 rescue experiments, in vitro expansion assays, quiescence analysis by flow cytometry Haematologica Medium 33299232
2023 Nupr1 regulates HtrA1 (a serine protease) expression in osteoblasts/osteocytes, thereby suppressing SMAD1 signaling and osteoblastogenesis. Nupr1 deficiency reduces HtrA1 expression and enhances SMAD1 signaling; Nupr1 overexpression enhances HtrA1 expression. Nupr1-KO mice, differential gene expression analysis in osteocytes, in vitro primary osteoblast cultures with Nupr1 overexpression/deficiency, SMAD1 phosphorylation assays, senescence marker analysis Journal of cellular physiology Medium 36715607
2025 Tumor-derived lactate upregulates NUPR1 expression in macrophages via histone lactylation, and NUPR1 in turn inhibits ERK and JNK signaling pathways, promoting M2 macrophage polarization and increased expression of PD-L1 and SIRPA. scRNA-seq, functional in vitro and in vivo assays, histone lactylation analysis, ERK/JNK signaling pathway assays, NUPR1 knockdown in macrophages, PD-1 blockade combination experiments Advanced science Medium 40305758
2025 NR3C1 (glucocorticoid receptor) directly regulates NUPR1 transcription in response to psychological stress, which in turn increases SNAI2 (Slug) expression to drive EMT and ovarian tumor metastasis. Chronic restraint stress mouse model, NR3C1 transcriptional regulation assay at NUPR1 promoter, SNAI2 expression assays, EMT marker analysis, NR3C1-NUPR1 correlation in patient data Acta pharmaceutica Sinica. B Medium 40654365
2025 FTO (m6A demethylase) stabilizes NUPR1 mRNA by targeting the +451 m6A site, thereby preventing YTHDF2-mediated degradation of NUPR1 mRNA, leading to increased NUPR1 protein and downstream LCN2/FTH1-mediated iron homeostasis and chemoresistance in colorectal cancer. CRISPR/Cas9 FTO knockout cells and mice, m6A site mapping, YTHDF2 interaction assays, mRNA stability assays, LCN2/FTH1 expression analysis, chemotherapy sensitivity assays Redox biology Medium 40334546
2023 WTAP promotes NUPR1 expression via m6A modification in an eIF3A-mediated manner (m6A-EIF3A), which in turn upregulates LCN2 and suppresses ferroptosis in triple-negative breast cancer. m6A dot blot assay, NUPR1 mRNA stability assay, RIP assay (eIF3a-NUPR1 interaction), NUPR1 silencing, LCN2 knockdown, ferroptosis markers (GSH/GSSG, Fe2+) Biochemical genetics Medium 37477758
2021 NUPR1 promotes FTH1 transcription in HCC cells (via the circPIAS1/miR-455-3p/NUPR1/FTH1 axis), enhancing iron storage and conferring ferroptosis resistance. CircPIAS1 sequesters miR-455-3p to upregulate NUPR1. RNA immunoprecipitation, luciferase reporter assays, ChIP (NUPR1 on FTH1 promoter), FISH, NUPR1 inhibitor ZZW-115, ferroptosis assays, xenograft models Molecular cancer Medium 38802795
2021 NUPR1 promotes PPAR-α signaling via the UPR, protecting liver from lipotoxic injury. NUPR1 loss-of-function in mice fed high-fat diet results in impaired UPR activation and reduced PPAR-α signaling, leading to increased hepatic steatosis. Nupr1-/- mice on high-fat diet, UPR pathway analysis, PPAR-α signaling assays, patient liver biopsy analysis, immunohistochemistry, mRNA analysis FASEB journal Medium 33566371
2024 NUPR1 mediates METH-induced pulmonary arterial smooth muscle cell (PASMC) phenotypic conversion from contractile to synthetic by activating STIM1 expression, which opens store-operated calcium entry (SOCE) channels, promoting Ca2+ influx and pulmonary artery remodeling. NUPR1 expression analysis in human/mouse lung specimens, PASMC NUPR1 knockdown/overexpression, STIM1 expression assays, Ca2+ influx (SOCE) measurement, pulmonary artery remodeling histology, right ventricular systolic pressure measurement Cell biology and toxicology Medium 38347241
2019 Amphipathic helical peptides bind to NUPR1 around Ala33 and C-terminus residues (low micromolar Kd ~3 µM), inhibiting NUPR1-RING1B interaction in cellulo. The Thr68Gln mutant of NUPR1 does not interact with these peptides. Fluorescence, circular dichroism, NMR, ITC, docking/MD simulations, proximity ligation assays (in cellulo for NUPR1-RING1B interaction inhibition), site-directed mutagenesis (Thr68Gln) Biochimica et biophysica acta. General subjects Medium 29530795
2008 Loss of NUPR1 (p8) in mice results in delayed LHB (luteinizing hormone beta subunit) expression during gonadotroph development, ovarian maturation delay (absence of corpora lutea at 8 weeks), and age-related testicular germ cell loss resembling Sertoli-cell-only syndrome, demonstrating a role for NUPR1 in temporal regulation of LHB and gonadal function. Nupr1-/- mouse model, RT-qPCR for LHB/FSHB/GATA2/CGA/TSH expression at embryonic time points, gonadal histology, corpora lutea assessment Biology of reproduction Medium 18495683
2019 AP-1 (via JUN binding sites) transcriptionally regulates NUPR1 in response to nickel exposure. Knockdown of JUN or FOS suppresses NUPR1 induction by Ni. Deletion of the upstream JUN binding site in the NUPR1 promoter reduces promoter activity. Luciferase reporter assay with NUPR1 promoter, JUN binding site deletion (site-directed mutagenesis), JUN/FOS knockdown experiments, NUPR1 promoter cloning Oncology reports Medium 33649793

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 NUPR1 is a critical repressor of ferroptosis. Nature communications 235 33510144
2009 Emerging role of nuclear protein 1 (NUPR1) in cancer biology. Cancer metastasis reviews 106 19153668
2022 NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy. Signal transduction and targeted therapy 102 35462576
2011 Nupr1: the Swiss-knife of cancer. Journal of cellular physiology 98 20658514
2016 NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance. Cell death & disease 95 27336713
2019 Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. The Journal of clinical investigation 88 30920390
2017 NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. Autophagy 84 29130426
2017 Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Frontiers in molecular neuroscience 80 28694771
2008 NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress. Current cancer drug targets 70 18690848
2024 CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis. Molecular cancer 66 38802795
2012 Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. Clinical cancer research : an official journal of the American Association for Cancer Research 63 22899799
2021 NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner. Cell death discovery 62 34599149
2018 Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. Scientific reports 56 30451898
2021 NUPR1: A Critical Regulator of the Antioxidant System. Cancers 55 34359572
2016 Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell death & disease 55 27031958
2012 Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. FEBS letters 55 22858377
2021 NUPR1 and its potential role in cancer and pathological conditions (Review). International journal of oncology 50 33760183
2009 p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. Journal of cellular physiology 49 19650074
2015 Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression. Hepatology (Baltimore, Md.) 48 26173068
2012 Lentivirus-mediated RNAi knockdown of NUPR1 inhibits human nonsmall cell lung cancer growth in vitro and in vivo. Anatomical record (Hoboken, N.J. : 2007) 48 22961798
2019 Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells 45 31744261
2017 Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B. Proceedings of the National Academy of Sciences of the United States of America 44 28720707
2020 ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. JCI insight 42 32780723
2014 Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. Cell death and differentiation 42 24902898
2018 Long Noncoding RNA FEZF1-AS1 Promotes Osteosarcoma Progression by Regulating the miR-4443/NUPR1 Axis. Oncology research 40 29510778
2022 NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma. BMC medicine 39 36258210
2016 Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. Journal of neuro-oncology 39 28000106
2013 Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity. PloS one 39 24205110
2018 LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer. The international journal of biochemistry & cell biology 37 30267804
2025 Lactylation-Driven NUPR1 Promotes Immunosuppression of Tumor-Infiltrating Macrophages in Hepatocellular Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 36 40305758
2016 Downregulation of YAP-dependent Nupr1 promotes tumor-repopulating cell growth in soft matrices. Oncogenesis 36 27089143
2022 The role of NUPR1 in response to stress and cancer development. Toxicology and applied pharmacology 35 36116561
2018 A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids. Redox biology 35 30466060
2013 Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis. Gut 35 24026351
2020 Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma. Cancer letters 34 32446862
2016 Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1. PloS one 33 27285315
2023 WTAP Mediates NUPR1 Regulation of LCN2 Through m6A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion. Biochemical genetics 30 37477758
2021 Nupr1 mediates renal fibrosis via activating fibroblast and promoting epithelial-mesenchymal transition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30 33617091
2021 Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells. International journal of molecular sciences 30 33920455
2020 NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway. DNA and cell biology 30 31971825
2012 The human NUPR1/P8 gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway. The Biochemical journal 30 22738338
2021 CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637. Annals of translational medicine 28 34164494
2021 Crowding Effects on the Structure and Dynamics of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1. Frontiers in molecular biosciences 27 34291085
2018 Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1). Biochimica et biophysica acta. General subjects 26 29530795
2015 Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation. Scientific reports 26 26617245
2020 A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin. Biomolecules 25 32933064
2012 NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells. Autophagy 25 23047430
2021 Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function. Biomolecules 24 34680086
2019 Inhibition of ROS/NUPR1-dependent autophagy antagonises repeated cadmium exposure -induced oral squamous cell carcinoma cell migration and invasion. Toxicology letters 24 31319114
2019 LINC01234 facilitates growth and invasiveness of oral squamous cell carcinoma through regulating the miR-637/NUPR1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 24 31590125
2018 Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis. Oncology reports 24 30015974
2020 Quercetin induced NUPR1-dependent autophagic cell death by disturbing reactive oxygen species homeostasis in osteosarcoma cells. Journal of clinical biochemistry and nutrition 23 33041510
2019 Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes. Bioscience reports 22 30674641
2020 Trifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma. FEBS open bio 21 32810364
2024 Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors. EMBO molecular medicine 19 38360999
2016 Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo. Journal of the American Society of Nephrology : JASN 19 27451286
2013 Nupr1 deletion protects against glucose intolerance by increasing beta cell mass. Diabetologia 19 23900510
2022 NUPR1 promotes the proliferation and migration of breast cancer cells by activating TFE3 transcription to induce autophagy. Experimental cell research 18 35660538
2021 NUPR1 is a novel potential biomarker and confers resistance to sorafenib in clear cell renal cell carcinoma by increasing stemness and targeting the PTEN/AKT/mTOR pathway. Aging 18 34030133
2012 Expression and roles of NUPR1 in cholangiocarcinoma cells. Anatomy & cell biology 18 22536548
2022 NUPR1 protects against hyperPARylation-dependent cell death. Communications biology 17 35869257
2021 The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma. Cancer letters 17 34314755
2020 NUPR1 preserves insulin secretion of pancreatic β-cells during inflammatory stress by multiple low-dose streptozotocin and high-fat diet. American journal of physiology. Endocrinology and metabolism 17 32574111
2019 Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm. Molecular & cellular oncology 17 31528692
2008 Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice. Biology of reproduction 17 18495683
2022 Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica 16 33299232
2022 NUPR1 imparts oncogenic potential in bladder cancer. Cancer medicine 16 36468653
2023 SETD4 inhibits prostate cancer development by promoting H3K27me3-mediated NUPR1 transcriptional repression and cell cycle arrest. Cancer letters 15 37879429
2014 Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins. Journal of molecular modeling 15 25056123
2023 Intrinsically Disordered Chromatin Protein NUPR1 Binds to the Enzyme PADI4. Journal of molecular biology 14 36858171
2020 Combination of AAV‑mediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549 cells in nude mice. Oncology reports 14 31922247
2020 MicroRNA-325-3p prevents sevoflurane-induced learning and memory impairment by inhibiting Nupr1 and C/EBPβ/IGFBP5 signaling in rats. Aging 14 32191629
2019 Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1. Biomacromolecules 14 31181156
2015 Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1. Journal of cellular physiology 14 25899918
2022 The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis. Cell death discovery 13 36307402
2021 NUPR1 interacts with eIF2α and is required for resolution of the ER stress response in pancreatic tissue. The FEBS journal 13 33403797
2021 NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 13 33566371
2020 Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1. International journal of biological macromolecules 13 33385445
2019 NUPR1 acts as a pro-survival factor in human bone marrow-derived mesenchymal stem cells and is induced by the hypoxia mimetic reagent deferoxamine. Journal of clinical biochemistry and nutrition 13 31138954
2019 Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α. Biochimica et biophysica acta. Proteins and proteomics 13 31325636
2019 The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS neglected tropical diseases 13 31344041
2019 Epigenetic silencing of microRNA-874-3p implicates in erectile dysfunction in diabetic rats by activating the Nupr1/Chop-mediated pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 12 31914690
2025 FTO facilitates colorectal cancer chemoresistance via regulation of NUPR1-dependent iron homeostasis. Redox biology 11 40334546
2024 Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway. Journal of translational medicine 11 39090667
2020 Oncogenic Role of NUPR1 in Ovarian Cancer. OncoTargets and therapy 11 33299325
2019 Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 11 31067083
2017 [Knockdown of nuclear protein 1 (NUPR1) gene inhibits proliferation and promotes apoptosis of human multiple myeloma U266 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 11 29089084
2024 Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension. Cell biology and toxicology 10 38347241
2023 Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways. Open medicine (Warsaw, Poland) 10 37854285
2021 NUPR1 participates in YAP-mediate gastric cancer malignancy and drug resistance via AKT and p21 activation. The Journal of pharmacy and pharmacology 10 33793788
2021 Induction of NUPR1 and AP‑1 contributes to the carcinogenic potential of nickel. Oncology reports 9 33649793
2021 NUPR1- CHOP experssion, autophagosome formation and apoptosis in the postmortem striatum of chronic methamphetamine user. Journal of chemical neuroanatomy 9 33675952
2023 Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice. Journal of cellular physiology 8 36715607
2021 DUXAP8 knockdown inhibits the development of melanoma by regulating the miR-3182/NUPR1 pathway. Oncology letters 8 33981357
2025 Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis. Acta pharmaceutica Sinica. B 7 40654365
2024 Development of an efficient NUPR1 inhibitor with anticancer activity. Scientific reports 7 39604425
2023 Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta-Gonad-Mesonephros Region. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 36638254
2022 Trifluoperazine Synergistically Potentiates Bortezomib-Induced Anti-Cancer Effect in Multiple Myeloma via Inhibiting P38 MAPK/NUPR1. The Tohoku journal of experimental medicine 7 35644544
2020 microRNA-637 promotes apoptosis and suppresses proliferation and autophagy in multiple myeloma cell lines via NUPR1. FEBS open bio 7 33332746
2025 PCSK9 Promotes Atherosclerotic Plaque Instability by Inducing VSMC Ferroptosis through the YAP1-NUPR1 Axis. Research (Washington, D.C.) 6 41064368

Missed literature

Know a paper Affinage missed for NUPR1? Flag it for the maintainers and the community.

No submissions yet.