Affinage

NUDC

Nuclear migration protein nudC · UniProt Q9Y266

Length
331 aa
Mass
38.2 kDa
Annotated
2026-06-10
49 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NUDC is a CS-domain co-chaperone of the Hsp90 system that stabilizes a defined set of cytoskeletal and motility client proteins and, through them, governs nuclear and cell migration, mitosis, cytokinesis, and ciliogenesis (PMID:20675372, PMID:35063133, PMID:12679384). Mechanistically it acts as an essential transfer factor that engages Hsp40 within Hsp40–Hsp70–client complexes, displaces Hsp70, and hands clients to Hsp90 for activation, an activity required for cellular viability (PMID:35063133); it also possesses intrinsic chaperone (anti-aggregation) activity and dimerizes through an N-terminal coiled coil (PMID:21530541). Its best-defined clients include LIS1, whose stabilization places NUDC upstream of LIS1 in the cytoplasmic dynein pathway controlling nuclear and neuronal migration (PMID:20675372, PMID:9013770, PMID:21771589), cofilin 1, through which NUDC regulates actin dynamics and ciliogenesis (PMID:26704451), and filamin A, required for cell migration (PMID:34262899). In mitosis NUDC is a substrate and spatial regulator of mitotic kinases: Plk1 phosphorylates it at S274/S326 to target Plk1 to kinetochores and drive chromosome congression and cytokinesis (PMID:12852857, PMID:16860740), Aurora B phosphorylates it at T40 to control abscission (PMID:27074040), and HDAC3-dependent deacetylation at K39 is required for proper spindle function (PMID:24069238). NUDC is recruited to the mitotic spindle by EML4 (PMID:25789526) and its abundance is controlled by RNF41-mediated ubiquitination and proteasomal degradation (PMID:40494872). NUDC also supports photoreceptor outer-segment biogenesis in a LIS1-independent manner involving dynein- and cofilin-dependent processes (PMID:38441532, PMID:31022349).

Mechanistic history

Synthesis pass · year-by-year structured walk · 22 steps
  1. 1997 High

    Established that NUDC is a conserved component of the nuclear migration pathway acting genetically upstream of the LIS1 ortholog, framing all subsequent dynein-related work.

    Evidence Functional complementation of the Aspergillus nudC3 mutant by rat NudC, restoring NudF protein levels

    PMID:9013770

    Open questions at the time
    • Did not define the biochemical mechanism by which NudC supports NudF/LIS1
    • Cross-species complementation does not establish the mammalian molecular interaction
  2. 1998 High

    Answered whether NUDC physically engages LIS1, providing the molecular basis for the genetic epistasis seen in fungi.

    Evidence Yeast two-hybrid, in vitro pulldown, and reciprocal co-IP from mouse brain extracts

    PMID:9601647

    Open questions at the time
    • Did not address whether binding is direct or chaperone-mediated
    • No functional consequence of the interaction defined
  3. 2001 High

    Placed NUDC within the cytoplasmic dynein motor complex at the MTOC during neuronal migration, connecting it to motor-driven movement.

    Evidence Immunofluorescence colocalization and co-IP of NudC with dynein intermediate and heavy chains from brain

    PMID:11734602

    Open questions at the time
    • Did not distinguish whether NudC is a structural motor subunit or a regulatory chaperone
    • Stoichiometry within the complex unknown
  4. 2003 High

    Demonstrated a mitotic/cytokinetic role and linked NUDC to Plk1 localization, broadening its function beyond migration.

    Evidence siRNA knockdown and overexpression in mammalian cells plus RNAi in C. elegans with cytokinesis phenotypes; Plk1 mislocalization

    PMID:12679384

    Open questions at the time
    • Mechanism of Plk1 mislocalization not defined
    • Whether effect is direct or via cytoskeletal disruption unresolved
  5. 2003 High

    Established a direct kinase-substrate relationship by showing Plk1 phosphorylates NudC at S274/S326 and that this is functionally required for cytokinesis.

    Evidence cDNA phage display, in vitro and in vivo kinase assays, and phospho-site mutant rescue of RNAi defects

    PMID:12852857

    Open questions at the time
    • Did not explain how phosphorylation alters NudC function biochemically
    • Downstream effectors of phospho-NudC undefined
  6. 2006 High

    Defined NUDC as both substrate and spatial regulator of Plk1 at kinetochores, linking it to chromosome congression.

    Evidence siRNA knockdown, kinetochore immunofluorescence, and phospho-mutant rescue showing loss of Plk1/CENP-E targeting

    PMID:16860740

    Open questions at the time
    • Mechanism of Plk1 recruitment by phospho-NudC not structurally defined
    • Relationship between kinetochore and cytokinesis roles unclear
  7. 2010 High

    Reframed NUDC as an Hsp90 co-chaperone whose chaperone activity stabilizes LIS1, explaining the basis of the long-known NudC–LIS1 epistasis.

    Evidence ATPase assays, Hsp90 binding, L279P chaperone-defective mutant, and pharmacological Hsp90 inhibition with LIS1 readout

    PMID:20675372

    Open questions at the time
    • Did not define the molecular step of client handoff
    • Whether all NudC functions are chaperone-dependent unresolved
  8. 2011 High

    Provided structural basis for co-chaperone identity (CS domain, coiled-coil dimerization) and intrinsic anti-aggregation activity.

    Evidence X-ray crystallography, NMR, and in vitro aggregation assays of NudC paralogs

    PMID:21530541

    Open questions at the time
    • No binary NudC–LIS1 complex formed in vitro, leaving direct binding mode unresolved
    • Paralog functional divergence not mechanistically explained
  9. 2011 High

    Confirmed an in vivo requirement for NUDC in interkinetic nuclear migration and neocortical neuronal migration.

    Evidence In utero electroporation of shRNA and mutant constructs in embryonic rat brain

    PMID:21771589

    Open questions at the time
    • Did not separate chaperone from dynein-complex contributions in vivo
    • Cell-autonomous vs non-autonomous effects not dissected
  10. 2013 High

    Identified acetylation as a regulatory layer, with HDAC3-mediated deacetylation at K39 required for spindle function.

    Evidence Mass spectrometry, K39Q/K39R rescue assays, co-IP with HDAC3, and HDAC3 inhibition

    PMID:24069238

    Open questions at the time
    • Acetyltransferase for K39 not identified
    • How acetylation alters NudC activity mechanistically unknown
  11. 2015 High

    Extended NUDC chaperone clientele to cofilin 1, linking NUDC to actin dynamics and ciliogenesis.

    Evidence Co-IP, knockdown/rescue epistasis in cells, and zebrafish morpholino phenotypes

    PMID:26704451

    Open questions at the time
    • Whether cofilin stabilization is Hsp90-dependent not tested here
    • Direct vs indirect binding undefined
  12. 2015 Medium

    Identified the spindle-recruitment mechanism by showing EML4 loads NudC onto the mitotic spindle via its WD40 repeat.

    Evidence Interactome MS, co-IP, siRNA, and immunofluorescence localization

    PMID:25789526

    Open questions at the time
    • Single-lab interaction without reciprocal structural validation
    • Whether EML4-loaded NudC carries clients to the spindle unknown
  13. 2016 High

    Defined Aurora B phosphorylation of NudC at T40 and showed dynamic dephosphorylation is required for abscission.

    Evidence Aurora B inhibition, T40A/T40D rescue assays, and midbody co-IP/colocalization

    PMID:27074040

    Open questions at the time
    • Phosphatase acting on T40 not identified
    • Interplay between T40, S274/S326, and K39 marks unresolved
  14. 2007 Medium

    Showed NUDC regulates an enzyme partner, increasing PAF-AH(I) catalytic activity via its conserved C-terminus.

    Evidence Co-IP and PAF-AH(I) activity assays with NudC deletion constructs

    PMID:17555748

    Open questions at the time
    • Single lab without structural mechanism
    • Physiological context of PAF-AH regulation not established
  15. 2010 Medium

    Mapped a NUDC interaction with the thrombopoietin receptor Mpl extracellular domain, hinting at a receptor-associated role.

    Evidence Yeast two-hybrid, co-IP, phage display, ELISA, and alanine-scanning mutagenesis

    PMID:20529857

    Open questions at the time
    • Functional/signaling consequence of binding not demonstrated
    • How an intracellular co-chaperone accesses an extracellular receptor domain unexplained
  16. 2019 Medium

    Implicated NUDC in photoreceptor disk formation through interactions with rhodopsin and Rab11a.

    Evidence Co-IP and shRNA knockdown/rescue in transgenic tadpole rods

    PMID:31022349

    Open questions at the time
    • Direct vs chaperone-mediated interactions undefined
    • Single-lab model-organism study
  17. 2020 Medium

    Added NAGK to the NudC–Lis1–dynein complex at the nuclear envelope as a migration regulator.

    Evidence Yeast two-hybrid, pulldown, proximity ligation, wound healing, and in utero electroporation

    PMID:33374456

    Open questions at the time
    • Mechanistic role of NAGK within the complex unclear
    • Single-lab interaction set
  18. 2022 High

    Resolved the central biochemical mechanism: NUDC is an essential transfer factor handing Hsp40-bound clients from Hsp70 to Hsp90.

    Evidence Biochemical reconstitution, co-IP, in vitro client activation, and genetic depletion

    PMID:35063133

    Open questions at the time
    • Full client spectrum of the transfer reaction undefined
    • Structural basis of Hsp70 displacement not solved
  19. 2022 High

    Demonstrated in vivo that NUDC stabilizes Lis1 to restrain dynein activity and microtubule stability in axon terminals.

    Evidence Forward genetic screen, immunofluorescence, Western blot, and pharmacological dynein inhibition in zebrafish

    PMID:36147950

    Open questions at the time
    • How NudC loss converts to excess dynein activity mechanistically unresolved
    • Generalizability beyond axon terminals untested
  20. 2024 High

    Established a LIS1-independent NUDC function in rod photoreceptors involving dynein- and cofilin-dependent processes.

    Evidence Conditional knockout in mouse rods with ERG, immunofluorescence, TEM, and Western blot

    PMID:38441532

    Open questions at the time
    • Direct molecular partners driving the LIS1-independent role unclear
    • Cause of rapid cell death not pinpointed
  21. 2025 Medium

    Identified RNF41 as the E3 ligase controlling NUDC abundance, linking NudC stability to tubulin polymerization and cancer cell invasion.

    Evidence Co-IP, ubiquitination assay, knockdown/overexpression, and migration assays in bladder cancer cells

    PMID:40494872

    Open questions at the time
    • Single-lab study
    • Whether ubiquitination targets specific NudC pools (spindle vs migration) untested
  22. 2026 Medium

    Revealed a dynein-independent role for NudC in ribosome biogenesis and translation in polyploid cells.

    Evidence RNAi in Drosophila salivary glands with ribosome profiling and RNA quantification

    PMID:42229917

    Open questions at the time
    • Direct molecular mechanism in rRNA/ribosome production unknown
    • Conservation in mammalian cells untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NUDC integrates its chaperone-mediated client transfer with its mitotic phospho/acetyl regulation and its newly described dynein-independent roles into a unified mechanism remains unresolved.
  • No structure of NudC bound to a client or to Hsp90/Hsp70 in the transfer state
  • Whether mitotic, migratory, ciliary, and ribosome-biogenesis functions share a single biochemical activity is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0044183 protein folding chaperone 3 GO:0098772 molecular function regulator activity 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005815 microtubule organizing center 2 GO:0005856 cytoskeleton 2 GO:0005635 nuclear envelope 1 GO:0005829 cytosol 1
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-1266738 Developmental Biology 2 R-HSA-392499 Metabolism of proteins 2
Partners
AURKBCFL1EML4FLNAHDAC3HSP90LIS1PLK1
Complex memberships
Hsp40-Hsp70-client complexHsp90 chaperone machinerycytoplasmic dynein complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Mammalian NudC physically interacts with Lis1 (the lissencephaly gene product), demonstrated by yeast two-hybrid screen, in vitro protein-protein interaction assays, and co-immunoprecipitation from mouse brain extracts. Yeast two-hybrid screen, in vitro pulldown assay, co-immunoprecipitation from mouse brain extracts Current biology : CB High 9601647
2001 NudC, Lis1, and cytoplasmic dynein intermediate chain (CDIC) colocalize at the MTOC at the leading pole of migrating cerebellar granule neurons; NudC co-immunoprecipitates with CDIC and cytoplasmic dynein heavy chain (CDHC) from mouse brain extracts, placing NudC in the dynein motor complex during neuronal migration. Immunofluorescence co-localization, co-immunoprecipitation from mouse brain extracts The Journal of neuroscience : the official journal of the Society for Neuroscience High 11734602
2003 NudC plays roles in mitosis and cytokinesis; siRNA knockdown or adenoviral overexpression causes multinucleated cells, persistent intercellular connections, and disorganized midzone/midbody matrix. Polo-like kinase 1 (Plk1) is mislocalized from centrosomes and midbody when NudC levels are altered. In C. elegans, silencing of nud-1 (NudC ortholog) causes loss of midzone microtubules and cleavage furrow regression. siRNA knockdown, adenovirus-mediated overexpression, immunofluorescence microscopy, RNAi in C. elegans Journal of cell science High 12679384
2003 NudC was identified as a Plk1 binding protein via cDNA phage display; Plk1 phosphorylates NudC at conserved S274 and S326 residues in vitro and in vivo. Rescue of NudC RNAi-induced cytokinesis defects (multinucleation, midbody arrest) requires wild-type NudC but not the S274A/S326A phosphorylation site mutant, establishing that Plk1 phosphorylation of NudC is functionally required for cytokinesis. cDNA phage display, in vitro kinase assay, in vivo phosphorylation assay, siRNA knockdown with rescue using phosphorylation-site mutants Developmental cell High 12852857
2006 NudC is required for Plk1 targeting to kinetochores and chromosome congression. Plk1-phosphorylated NudC colocalizes with Plk1 at the outer kinetochore plate. NudC depletion reduces end-on microtubule attachments at kinetochores and mislocalizes Plk1 and CENP-E from prometaphase kinetochores. Rescue requires wild-type NudC but not the Plk1 phosphorylation-site mutant, establishing NudC as both substrate and spatial regulator of Plk1 at the kinetochore. siRNA knockdown, immunofluorescence microscopy, rescue with phosphorylation-site mutants Current biology : CB High 16860740
2010 NudC functions as an Hsp90 co-chaperone to stabilize LIS1: NudC binds Hsp90, regulates Hsp90 ATPase activity, and possesses intrinsic chaperone activity. The L279P mutation (equivalent to the Aspergillus L146P temperature-sensitive mutation) impairs NudC chaperone function, reduces LIS1 protein levels, and causes LIS1-depletion-like cellular phenotypes. Hsp90 inhibition (geldanamycin/radicicol) decreases LIS1; ectopic Hsp90 partially rescues LIS1 degradation caused by NudC-L279P. Site-directed mutagenesis, ATPase activity assay, immunoprecipitation, pharmacological Hsp90 inhibition, Western blot The Journal of biological chemistry High 20675372
2011 Crystal structure and NMR analysis show human NudC contains a CS domain (characteristic of Hsp90 co-chaperones and small heat shock proteins) and dimerizes via an N-terminal coiled coil. NudC (and NudCL, but not NudCL2) inhibits aggregation of several target proteins in chaperone assays consistent with Hsp90-independent heat shock protein function. However, none of the three NudC paralogs formed binary complexes with Lis1 in these assays. X-ray crystallography, NMR, in vitro aggregation assay Journal of molecular biology High 21530541
2011 NudC is required for interkinetic nuclear migration in radial glial progenitors and for neuronal migration during neocorticogenesis in rat embryo, demonstrated by in utero electroporation of shRNAs and dominant-negative/wild-type NudC constructs. In utero electroporation, shRNA knockdown, overexpression of mutant forms in embryonic rat brain Developmental biology High 21771589
2013 NudC is deacetylated during mitosis; K39 is an acetylation site on NudC. The acetylation-mimetic K39Q mutant fails to rescue mitotic phenotypes (chromosome misalignment, missegregation, reduced spindle width) caused by NudC knockdown, while the acetylation-defective K39R mutant rescues these defects. NudC co-localizes and co-immunoprecipitates with HDAC3 on the mitotic spindle; HDAC3 knockdown or inhibition increases NudC acetylation, identifying HDAC3 as a deacetylase for NudC. Mass spectrometry identification of acetylation site, site-directed mutagenesis with rescue assay, co-immunoprecipitation, pharmacological HDAC3 inhibition PloS one High 24069238
2015 NudC binds to and stabilizes cofilin 1 (an actin dynamics regulator), thereby regulating actin organization and ciliogenesis. NudC depletion causes similar ciliary defects as cofilin 1 depletion (cilia elongation, increased ciliated cells, zebrafish curved body/pericardial edema/laterality defects). Ectopic cofilin 1 expression significantly reverses NudC depletion phenotypes, placing cofilin 1 downstream of NudC. Co-immunoprecipitation, siRNA knockdown, rescue experiments, zebrafish morpholino knockdown with phenotypic analysis Cell research High 26704451
2015 EML4 directly interacts with NudC (interaction mediated by EML4's WD40 repeat and the C-terminus of NudC) and is required for loading NudC onto the mitotic spindle. In EML4-depleted cells, NudC fails to localize to the mitotic spindle, while NudC depletion does not affect EML4 localization. Mass spectrometry interactome screen, co-immunoprecipitation, siRNA knockdown, immunofluorescence microscopy Cell cycle (Georgetown, Tex.) Medium 25789526
2016 Aurora B phosphorylates NudC at T40; NudC co-localizes and co-immunoprecipitates with Aurora B at the midbody during mitosis. Aurora B inhibition (ZM447439) reduces NudC phosphorylation in vivo. The T40D phospho-mimetic NudC fails to rescue cytokinesis defects (intercellular bridge elongation, sustained Aurora B activity, reduced abscission) caused by NudC depletion, while T40A rescues them, indicating that dynamic dephosphorylation at T40 is required for cytokinesis completion. In vivo kinase inhibition, site-directed mutagenesis with rescue assay, co-immunoprecipitation, immunofluorescence microscopy PloS one High 27074040
2019 NudC interacts with rhodopsin and the small GTPase Rab11a in rod photoreceptors. NudC is required for disk formation and photoreceptor protein localization in rod outer segments, as demonstrated by transgenic tadpole studies with NudC shRNA knockdown and rescue with murine NudC. Co-immunoprecipitation, shRNA knockdown in transgenic tadpoles, rescue experiments FASEB journal : official publication of the Federation of American Societies for Experimental Biology Medium 31022349
2021 NudC (as an Hsp90 co-chaperone) is required to stabilize filamin A; NudC interacts with filamin A (identified by IP-mass spectrometry). The chaperone-defective NudC-L279P mutant decreases filamin A protein levels, causes actin disorganization, and suppresses cell migration. Ectopic filamin A or Hsp90 reverses these defects, placing filamin A as an Hsp90/NudC client required for cell migration. Immunoprecipitation-mass spectrometry, Western blot, overexpression of NudC-L279P mutant, rescue with filamin A or Hsp90, pharmacological Hsp90 inhibition Frontiers in cell and developmental biology Medium 34262899
2022 NudC acts as an essential transfer factor between the Hsp40/70 and Hsp90 chaperone systems: NudC interacts with Hsp40 within Hsp40-Hsp70-client complexes and displaces Hsp70; NudC then interacts with Hsp90, enabling direct transfer of Hsp40-bound clients to Hsp90 for further processing. NudC increases client activation in vitro and in cells and is essential for cellular viability. Biochemical reconstitution, co-immunoprecipitation, in vitro client activation assay, genetic depletion Molecular cell High 35063133
2022 In zebrafish axon terminals, NudC acts as a chaperone for Lis1; loss of NudC function reduces Lis1 levels, causing dynein/dynactin accumulation and increased microtubule stability. Pharmacological dynein inhibition restores microtubule dynamics in nudc mutant axon terminals, placing excess dynein motor activity downstream of NudC/Lis1 depletion in microtubule regulation. Forward genetic screen, immunofluorescence, pharmacological dynein inhibition, Western blot in zebrafish iScience High 36147950
2024 Conditional knockout of NudC in mouse rod photoreceptors causes rhodopsin and mitochondria mislocalization (consistent with dynein inhibition), increased phosphorylated cofilin 1 (implicating NudC in cofilin 1-mediated actin depolymerization), ultrastructural outer segment defects, and rapid photoreceptor cell death by 6 weeks. LIS1 levels were unaffected, indicating a LIS1-independent role of NudC in rods. Conditional CRISPR/Cas9 knockout in mouse rods, electroretinography, immunofluorescence, transmission electron microscopy, Western blot FASEB journal : official publication of the Federation of American Societies for Experimental Biology High 38441532
2007 Mouse NudC interacts with the regulatory beta subunit of platelet-activating factor acetylhydrolase I (PAF-AH(I)) and increases PAF-AH(I) catalytic activity; this regulatory activity maps to the conserved C-terminal half of NudC. Co-immunoprecipitation, PAF-AH(I) enzymatic activity assay with NudC deletion constructs FEBS letters Medium 17555748
2025 RNF41 (an E3 ubiquitin ligase) directly interacts with NudC, ubiquitinates NudC, and promotes its proteasomal degradation. Loss of RNF41 increases NudC stability, which enhances β-tubulin polymerization and promotes bladder cancer cell migration and invasion. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown and overexpression, Western blot, in vitro migration assay Cell death & disease Medium 40494872
1997 Rat NudC (c15/RnudC) functionally complements the Aspergillus nudC3 nuclear migration mutant and restores NudF protein levels, demonstrating functional conservation of the nuclear migration role and indicating that NudC acts upstream of NudF (Lis1 ortholog) in the nuclear distribution pathway. Functional complementation in Aspergillus nidulans nudC3 temperature-sensitive mutant Molecular endocrinology (Baltimore, Md.) High 9013770
2010 Human NudC binds to the thrombopoietin receptor (Mpl) extracellular domain 1, specifically residues 206–251; two hydrophobic residues Leu228 and Leu230 are critical for hNUDC binding (identified by alanine replacement mutagenesis), and the WGSWS motif is required for hNUDC but not TPO binding. Yeast two-hybrid, co-immunoprecipitation, T7 phage display, ELISA binding assays, alanine scanning mutagenesis The Journal of biological chemistry Medium 20529857
2020 NAGK (N-acetylglucosamine kinase) interacts with NudC and Lis1 in the dynein complex; NAGK-NudC-Lis1-dynein complexes are detected around nuclei and at leading poles of migrating cells. NAGK overexpression accelerates cell migration while NAGK knockdown delays it; a NAGK peptide from the NudC-interacting domain retards migration, placing the NAGK-NudC-Lis1-dynein complex at the nuclear envelope as a regulator of cell migration. Yeast two-hybrid, pulldown assay, immunocytochemistry, proximity ligation assay, wound healing assay, in utero electroporation, shRNA knockdown International journal of molecular sciences Medium 33374456
2026 In Drosophila polyploid salivary gland cells, NudC depletion reduces ribosome abundance, impairs translation, decreases ribosomal RNA levels, and triggers a homeostatic transcriptional/translational upregulation of ribosome biogenesis factors. This role in ribosome biogenesis is independent of NudC's established function in dynein regulation. RNAi knockdown in Drosophila salivary glands, ribosome profiling, RNA quantification, immunofluorescence Open biology Medium 42229917

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 A role for Plk1 phosphorylation of NudC in cytokinesis. Developmental cell 132 12852857
1998 The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC. Current biology : CB 123 9601647
2003 Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Journal of cell science 102 12679384
2006 NudC is required for Plk1 targeting to the kinetochore and chromosome congression. Current biology : CB 77 16860740
2001 NudC associates with Lis1 and the dynein motor at the leading pole of neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 76 11734602
2016 Structure and function of the bacterial decapping enzyme NudC. Nature chemical biology 66 27428510
1997 Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal. Molecular biology of the cell 52 9307970
2006 A mammalian NudC-like protein essential for dynein stability and cell viability. Proceedings of the National Academy of Sciences of the United States of America 47 16754861
2015 NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1. Cell research 44 26704451
2022 NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Molecular cell 43 35063133
2007 Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta neuropathologica 41 17221205
1997 A prolactin-inducible T cell gene product is structurally similar to the Aspergillus nidulans nuclear movement protein NUDC. Molecular endocrinology (Baltimore, Md.) 41 9013770
1999 A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Experimental hematology 38 10210332
2011 NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development. Developmental biology 37 21771589
2010 The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability. The Journal of biological chemistry 33 20675372
2016 Emerging roles of NudC family: from molecular regulation to clinical implications. Science China. Life sciences 32 26965524
2010 NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. Proceedings of the National Academy of Sciences of the United States of America 31 20133715
2002 Involvement of the fungal nuclear migration gene nudC human homolog in cell proliferation and mitotic spindle formation. Experimental cell research 31 11795948
2011 Structural features and chaperone activity of the NudC protein family. Journal of molecular biology 30 21530541
2004 Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein. Oncogene 29 14676831
2000 The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in dividing cells and ciliated epithelia. Histochemistry and cell biology 28 11131094
2010 Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC). The Journal of biological chemistry 20 20529857
1999 Molecular cloning and characterization of the human NUDC gene. Human genetics 19 10453739
2009 The mammalian NudC-like genes: a family with functions other than regulating nuclear distribution. Cellular and molecular life sciences : CMLS 18 19381437
2008 The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies. Eukaryotic cell 18 18390647
2013 NudC deacetylation regulates mitotic progression. PloS one 16 24069238
2021 Structural insights into dpCoA-RNA decapping by NudC. RNA biology 14 34074215
2000 The nuclear migration gene NudC and human hematopoiesis. Leukemia & lymphoma 14 11342328
2015 EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell cycle (Georgetown, Tex.) 13 25789526
2020 N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1 in Dynein Motor Complex and Promotes Cell Migration. International journal of molecular sciences 12 33374456
2001 NUDC expression during amphibian development. The International journal of developmental biology 12 11732844
2019 NudC-like protein 2 restrains centriole amplification by stabilizing HERC2. Cell death & disease 11 31427565
2022 NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals. iScience 10 36147950
2007 Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity. FEBS letters 10 17555748
2023 HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p. Cell & bioscience 8 37596681
2019 NudC regulates photoreceptor disk morphogenesis and rhodopsin localization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 6 31022349
2016 Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. PloS one 6 27074040
2014 NudC Nudix hydrolase from Pseudomonas syringae, but not its counterpart from Pseudomonas aeruginosa, is a novel regulator of intracellular redox balance required for growth, motility and biofilm formation. Molecular microbiology 4 24989777
2006 [Expression and effects of nuclear distribution C (NUDC) protein in nasopharyngeal carcinoma cell lines]. Ai zheng = Aizheng = Chinese journal of cancer 4 16764765
2021 NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration. Frontiers in cell and developmental biology 3 34262899
2023 Interplay between bacterial 5'-NAD-RNA decapping hydrolase NudC and DEAD-box RNA helicase CsdA in stress responses. mSystems 2 37706681
2025 NUDC Is Critical for Mitosis and Postmitotic Cell Maintenance Through Its Modulation of Dynein and Actin Cytoskeletal Reorganization. Advances in experimental medicine and biology 1 39930237
2025 Loss of RNF41 promotes bladder cancer metastasis through increasing NUDC stability to enhance tubulin polymerization. Cell death & disease 1 40494872
2024 NUDC is critical for rod photoreceptor function, maintenance, and survival. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 38441532
2026 NudC moonlights in ribosome biogenesis and homeostasis in polyploid cells of Drosophila melanogaster. Open biology 0 42229917
2024 Birc5 and Nudc are screened as candidate reference genes for RT-qPCR studies in mouse cementoblast mineralization using time-series RNA-seq data. European journal of orthodontics 0 39066623
2023 Corrigendum: NudC L279P mutation destabilizes filamin a by inhibiting the Hsp90 chaperoning pathway and suppresses cell migration. Frontiers in cell and developmental biology 0 37056997
2023 NUDC is critical for rod photoreceptor function, maintenance, and survival. bioRxiv : the preprint server for biology 0 38076848
2011 [The construction of NUDC shRNA interference vector with red fluorescence protein]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 0 21722524

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