Affinage

NAB2

NGFI-A-binding protein 2 · UniProt Q15742

Length
525 aa
Mass
56.6 kDa
Annotated
2026-04-29
100 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NAB2 is a transcriptional coregulator of the EGR family of zinc-finger transcription factors that operates primarily as a repressor but can function context-dependently as a coactivator. NAB2 binds the R1 domain of EGR1, EGR2, and EGR3 through its NCD1 domain and recruits the CHD4/NuRD chromatin remodeling complex to repress target genes involved in mitogenesis, fibrosis, and angiogenesis, including tissue factor, collagen, VEGF, and TRAIL (PMID:8668170, PMID:16574654, PMID:12427750, PMID:19888474, PMID:22128144). EGR family members directly activate NAB2 transcription, while NAB2 represses its own promoter, establishing a negative feedback loop that limits EGR-dependent transcriptional programs in vascular, immune, and neural contexts (PMID:16260776, PMID:20506119). In solitary fibrous tumors, an intrachromosomal NAB2-STAT6 gene fusion converts NAB2 from a repressor into a nuclear transcriptional coactivator that drives EGR1-dependent neuroendocrine gene expression and cell proliferation (PMID:23313952, PMID:40875449).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1996 High

    Establishing that NAB2 is a transcriptional corepressor that directly binds EGR-family transcription factors resolved how EGR-driven transcription is attenuated, revealing the NCD1 domain as the interaction interface with the EGR R1 domain.

    Evidence Protein interaction mapping and transcriptional repression assays using NGFI-A/Krox20

    PMID:8668170

    Open questions at the time
    • No structural detail of the NCD1–R1 interaction
    • Mechanism of repression beyond binding not addressed
  2. 1997 High

    Mapping the NAB2 and STAT6 genes to convergent overlapping loci on 12q13 and identifying an alternatively spliced NAB2 isoform lacking repressor activity established the genomic architecture that later explained the recurrent NAB2-STAT6 fusion.

    Evidence Genomic sequencing, transcript analysis, and functional repression assays of splice variants

    PMID:9126479

    Open questions at the time
    • Physiological relevance of the alternative splice isoform unclear
    • Regulation of alternative splicing not defined
  3. 1998 High

    Demonstrating that NAB2 overexpression blocks NGF-induced differentiation and maintains proliferation in PC12 cells placed NAB2 as a functional antagonist of EGR1-driven differentiation programs at the cellular level.

    Evidence Stable transfection and adenoviral overexpression with gene expression analysis in PC12 cells

    PMID:9722618

    Open questions at the time
    • Endogenous loss-of-function not shown in this system
    • Direct target genes mediating the proliferative phenotype not identified
  4. 2001 High

    Showing that NAB2 suppresses EGR1-mediated transcription of tissue factor, PDGF, VEGF, and blocks angiogenesis in vitro expanded the biological scope of NAB2 repression to vascular biology and growth factor signaling.

    Evidence Reporter assays, dominant-negative analysis, ELISA, and in vitro angiogenesis assays

    PMID:11327726 PMID:12427750

    Open questions at the time
    • In vivo vascular phenotype of NAB2 loss not established at this point
    • Mechanism distinguishing dominant-negative from wild-type activity not fully resolved
  5. 2005 High

    Identifying that EGR1 directly activates the NAB2 promoter and NAB2 represses its own transcription established a negative feedback loop as the core regulatory logic of EGR-NAB signaling.

    Evidence Promoter cloning, reporter assay, EMSA, and siRNA knockdown of EGR1

    PMID:16260776 PMID:20506119

    Open questions at the time
    • Kinetics and dynamics of the feedback loop in physiological settings not modeled
    • Whether all EGR members contribute equally in different tissues unclear
  6. 2006 High

    Identifying CHD4/NuRD as the chromatin remodeling effector recruited by NAB2 resolved the mechanistic basis of transcriptional repression, showing that NAB2 represses targets by remodeling chromatin rather than simply blocking activator function.

    Evidence Co-immunoprecipitation, ChIP at the Rad promoter in Schwann cells, repression assays, and alternative splicing analysis

    PMID:16574654

    Open questions at the time
    • Whether CHD3 vs CHD4 recruitment differs functionally
    • Full composition of the NAB2-associated repressive complex not defined
  7. 2006 High

    Discovery that NAB2 can act as a coactivator of EGR1 at the IL-2 promoter in T cells revealed context-dependent dual functionality, challenging the view of NAB2 as a constitutive repressor.

    Evidence Overexpression, siRNA knockdown, ChIP at IL-2 promoter, and cytokine measurement in T cells

    PMID:17142725

    Open questions at the time
    • Molecular basis for the switch from corepressor to coactivator unknown
    • Whether coactivation involves distinct cofactors or post-translational modifications not tested
  8. 2009 High

    Demonstrating that Nab2 knockout mice exhibit increased dermal collagen accumulation, linked mechanistically to NuRD recruitment and histone deacetylation at COL1A2, provided the first in vivo genetic evidence that NAB2 is an endogenous anti-fibrotic factor.

    Evidence Nab2 knockout mouse, ChIP showing NuRD occupancy at COL1A2, collagen synthesis assays

    PMID:19888474

    Open questions at the time
    • Full spectrum of fibrotic target genes repressed by NAB2 in vivo not mapped
    • Whether NAB2 loss phenocopies specific fibrotic diseases not tested
  9. 2011 High

    Showing that NAB2 represses TRAIL in CD8+ T cells to enable secondary expansion—rescuable by TRAIL blockade—established NAB2 as a regulator of adaptive immune memory through an epistatic mechanism.

    Evidence Retroviral overexpression, dominant-negative expression, TRAIL blockade rescue in CD8+ T cells

    PMID:22128144

    Open questions at the time
    • Whether NAB2 regulation of TRAIL is direct or via intermediate EGR targets at the chromatin level
    • Relevance to infection models in vivo not shown
  10. 2013 High

    Discovery of the NAB2-STAT6 gene fusion as the universal driver of solitary fibrous tumors fundamentally reframed NAB2's disease relevance, showing that fusion of its EGR-binding domain to the STAT6 transactivation domain converts NAB2 from a repressor to a nuclear transcriptional activator driving proliferation.

    Evidence Whole-exome/transcriptome sequencing of 51 SFTs, RT-PCR validation, overexpression in cultured cells, proximity ligation assay, and STAT6 IHC

    PMID:23313952 PMID:23575898

    Open questions at the time
    • Precise mechanism by which the fusion activates rather than represses at EGR-bound sites
    • Whether the fusion requires endogenous EGR1 or can function autonomously
  11. 2018 High

    Mapping the NAB2 nuclear localization signal to the KKXK343-346 motif resolved how NAB2 enters the nucleus and clarified why endogenous STAT6 (normally cytoplasmic) becomes nuclear when fused to NAB2.

    Evidence Site-directed mutagenesis, GFP fusion localization, domain transplantation to eIF2Bε

    PMID:30411343

    Open questions at the time
    • Import receptor that recognizes the KKXK motif not identified
    • Whether NLS masking regulates NAB2 cytoplasmic retention under certain conditions
  12. 2025 High

    Genome-wide chromatin profiling established that NAB2-STAT6 functions as a coactivator at EGR1-targeted enhancers and promoters, activating a neuronal/neuroendocrine gene signature and redirecting endogenous NAB1, NAB2, and EGR1 to the nucleus, resolving the transcriptional mechanism underlying SFT oncogenesis.

    Evidence Inducible cell model, primary SFT samples, ChIP-seq/ATAC-seq, transcriptomics

    PMID:40875449

    Open questions at the time
    • How the STAT6 transactivation domain overrides NuRD-mediated repression mechanistically
    • Whether therapeutic disruption of the NAB2-STAT6–EGR1 interaction is feasible

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular basis for context-dependent switching between corepression and coactivation by wild-type NAB2, the identity of the nuclear import receptor recognizing KKXK, and the structural details of the NCD1–EGR R1 interaction remain unresolved.
  • No crystal or cryo-EM structure of NAB2 or the NAB2–EGR complex
  • Mechanism of coactivation at IL-2 and BCAR1 promoters not reconciled with NuRD-dependent repression
  • Post-translational modifications regulating NAB2 function largely uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 1
Pathway
R-HSA-74160 Gene expression (Transcription) 6 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-4839726 Chromatin organization 2
Partners
CHD3CHD4EGR1EGR2EGR3STAT6WT1
Complex memberships
NuRD complex (via CHD4)

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 NAB2 functions as a transcriptional corepressor that directly interacts with the R1 domain of NGFI-A (Egr-1) and Krox20, repressing their transcriptional activation activity. The first conserved domain (NCD1) of NAB2 mediates this interaction. Protein interaction mapping, transcriptional repression assays Molecular and cellular biology High 8668170
2006 NAB2 represses transcription via at least two repression domains, one of which requires interaction with CHD4, a subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex. Both NAB1 and NAB2 bind CHD3 or CHD4. NAB2 and CHD4 co-occupy the Rad gene promoter in myelinating Schwann cells, and interaction with CHD4 is regulated by alternative splicing of NAB2 mRNA. Co-immunoprecipitation, chromatin immunoprecipitation, transcriptional repression assays, alternative splicing analysis The Journal of biological chemistry High 16574654
2005 Egr-1 directly activates the NAB2 promoter through Egr-binding sites (including a cluster between -329 and -260 bp), and NAB2 in turn represses its own promoter, establishing a negative feedback loop. Depletion of Egr-1 by siRNA reduces NAB2 expression. Promoter cloning, reporter assay, EMSA, siRNA knockdown The Journal of biological chemistry High 16260776
1998 Overexpression of NAB2 in PC12 cells inhibits NGF-induced differentiation and maintains proliferation, while downstream NGF response genes (TGF-beta1, MMP-3) are repressed and p21(WAF1) is downregulated. This places NAB2 as a repressor of Egr1-dependent differentiation programs. Stable transfection, adenoviral overexpression, gene expression analysis The Journal of cell biology High 9722618
2002 NAB2 overexpression inhibits VEGF-induced expression of tissue factor, VEGF receptor-1, and urokinase plasminogen activator, and blocks tubule and sprout formation in angiogenesis assays. NAB2 levels are reciprocally regulated with EGR-1 following VEGF treatment. Adenovirus-mediated overexpression, reporter assay, in vitro angiogenesis assay, Matrigel model The Journal of biological chemistry High 12427750
2013 NAB2-STAT6 gene fusion is the defining driver mutation of solitary fibrous tumor (SFT). The fusion protein harbors the EGR-binding domain of NAB2 fused to the transactivation domain of STAT6, converting a transcriptional repressor into a transcriptional activator. Overexpression of NAB2-STAT6 induces proliferation and activates EGR-responsive genes. Whole-exome and transcriptome sequencing, RT-PCR, overexpression in cultured cells, gene expression analysis Nature genetics High 23313952
2013 The NAB2-STAT6 fusion protein causes nuclear relocalization of STAT6 (normally cytoplasmic), which can be used as a surrogate diagnostic marker. Tissues without the fusion show nuclear NAB2 and cytoplasmic STAT6. Proximity ligation assay, STAT6 immunohistochemistry, exome sequencing Acta neuropathologica High 23575898
2009 NAB2 suppresses TGF-beta-induced fibroblast activation (collagen synthesis and myofibroblast differentiation) by recruiting the NuRD chromatin remodeling complex to the COL1A2 promoter, reducing histone H4 acetylation. Nab2 knockout mice show increased dermal collagen accumulation. Ectopic expression, siRNA knockdown, ChIP, Nab2 knockout mouse model, collagen synthesis assay PloS one High 19888474
2006 NAB2 acts as a coactivator for Egr-1 at the IL-2 promoter in T cells: NAB2 overexpression enhances IL-2 production while siRNA-mediated knockdown inhibits it. ChIP shows NAB2 is recruited to the Egr-1 binding site on the IL-2 promoter. Overexpression, siRNA knockdown, chromatin immunoprecipitation, cytokine measurement Journal of immunology High 17142725
2011 NAB2 regulates secondary CD8+ T-cell responses by repressing TRAIL expression. Enforced NAB2 expression prevents TRAIL induction in helpless CD8+ T cells after restimulation; dominant-negative NAB2 impairs secondary proliferation reversible by TRAIL blockade. IL-2 coordinately increases NAB2 and decreases TRAIL. Retroviral overexpression, dominant-negative expression, TRAIL blockade, transcriptional profiling Blood High 22128144
2010 EGR1, EGR2, and EGR3 all activate NAB2 transcription through similar cis-regulatory elements in melanoma/carcinoma cells, and NAB2 represses this activation, establishing a negative feedback loop. siRNA depletion of each EGR reduces endogenous NAB2 levels. Reporter assay, siRNA knockdown, promoter analysis Journal of cellular biochemistry High 20506119
1999 NAB2 is expressed in vascular smooth muscle cells (VSMC) in response to PMA and FGF-2, trails Egr-1 induction kinetically, and inhibits Egr-1-dependent gene expression in VSMC. NAB2 levels also increase transiently in vivo after mechanical arterial injury coinciding with elevated Egr-1. Western blot, mRNA analysis, reporter assay, in vivo arterial injury model The American journal of pathology High 10514413
2001 NAB2 blocks Egr-1-mediated transcriptional activation of tissue factor promoter and suppresses production of PDGF-AB, HGF, TGFbeta1, and VEGF. Wild-type but not dominant-negative NAB2 blocks tubule formation in an in vitro angiogenesis model. Reporter assay, dominant-negative analysis, ELISA, in vitro angiogenesis assay Biochemical and biophysical research communications High 11327726
2020 NAB2-STAT6 fusion activates EGR-1 transcription and its target gene IGF2, upregulates cyclin D1 and phospho-Rb, and enhances cell proliferation and oncogenic transformation. IGF2 inhibitor treatment reduces NAB2-STAT6-driven proliferation. Transfection, Western blot, gene expression analysis, IGF2 inhibitor treatment, soft-agar assay Biochemical and biophysical research communications Medium 32216968
2025 NAB2-STAT6 operates as a transcriptional coactivator at EGR1-targeted enhancers and promoters. In physiological conditions, NAB2 is primarily cytoplasmic; NAB2-STAT6 redirects NAB1, NAB2, and EGR1 to the nucleus and bolsters expression of neuronal EGR1 targets. The STAT6 moiety drives nuclear localization of the fusion and contributes to co-activating ability. The fusion activates a neuroendocrine gene signature in SFTs. Inducible cell model, primary tumor samples, ChIP-seq/ATAC-seq, transcriptomics eLife High 40875449
2018 The nuclear localization signal (NLS) of NAB2 maps to the KKXK343-346 motif, which is necessary and sufficient for nuclear localization. Mutation of KKXK to AAXA causes cytoplasmic mislocalization; upstream K(X2)R motif is dispensable. Fusion of KKXK to cytoplasmic eIF2Bε causes its nuclear import. Site-directed mutagenesis, GFP fusion localization, domain transplantation FEBS letters High 30411343
2006 FGF23 induces two isoforms of NAB2 (corepressors of Egr-1) in addition to Egr-1 itself. Both NAB2 isoforms are nuclear and suppress Egr-1 transcriptional activity, establishing a negative feedback loop downstream of FGF23 signaling. Expression analysis, nuclear localization assay, transcriptional reporter assay Biochemical and biophysical research communications Medium 17174939
2012 EGR1 and NAB2 act in concert to positively regulate p130(Cas)/BCAR1 expression in breast cancer cells. ChIP shows both EGR1 and NAB2 are recruited to the BCAR1 5' region. In MCF-7 cells, p130(Cas) positively regulates EGR1 and NAB2 in a feedback loop. Overexpression, siRNA knockdown, chromatin immunoprecipitation, reporter assay Neoplasia Medium 22431919
2017 WT1 binds and transactivates the proximal NAB2 promoter, and WT1 can recruit NAB2 to the IRF8 promoter, where NAB2 modulates WT1 transcriptional activity. ChIP, luciferase reporter assay, overexpression/knockdown of WT1 Oncotarget Medium 29152069
2013 NAB2 and EGR-1 exert opposing roles in regulating TRAIL expression in NK cells: NAB2 promotes TRAIL induction while EGR-1 acts as a brake. NAB2 is induced by IL-2 and IL-15 in NK cells. Overexpression, knockdown, cytokine stimulation, TRAIL expression analysis Immunology letters Medium 23416169
2008 TCR-induced Egr-1 and NAB2 enhance T cell function and require AP-1-mediated transcription. Egr-2 and Egr-3 (induced by NF-AT without AP-1) suppress Egr-1 and NAB2 expression. Egr-3 is upstream of Egr-2. T cells from Egr-2/3 null mice are hyperresponsive while Egr-3 transgenic T cells are hyporesponsive. Genetic mouse models (knockout, transgenic), transcriptional reporter analysis, T cell functional assays European journal of immunology High 18203138
1997 The NAB2 and STAT6 genes are in close genomic proximity on chromosome 12q13 with convergent transcripts that overlap by 58 bp. Alternative splicing of NAB2 (lacking exon 3) produces a protein lacking the ability to repress NGFI-A/Krox20. Genomic sequencing, transcript analysis, functional repression assay Genomics High 9126479

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nature genetics 609 23313952
1996 NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Molecular and cellular biology 327 8668170
2013 Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta neuropathologica 286 23575898
2014 Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. The American journal of pathology 187 24513261
1993 NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability. Molecular and cellular biology 157 8474438
2015 NAB2-STAT6 fusion types account for clinicopathological variations in solitary fibrous tumors. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 129 26226844
2014 Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. Human pathology 115 25582503
2014 Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour. Histopathology 103 24702701
2006 NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. The Journal of biological chemistry 96 16574654
2009 Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. The Journal of biological chemistry 95 19840948
2008 Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. European journal of immunology 94 18203138
2005 Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop. The Journal of biological chemistry 89 16260776
2002 NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. The Journal of biological chemistry 88 12427750
2010 EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin. Journal of cellular biochemistry 66 20506119
2008 Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export. The Journal of biological chemistry 66 18682389
2018 The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma. Acta neuropathologica 62 30584643
1998 Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. Molecular and cellular biology 62 9488461
2015 The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors. Cancer medicine 60 26686340
2016 NAB2-STAT6 Gene Fusion in Meningeal Hemangiopericytoma and Solitary Fibrous Tumor. Journal of neuropathology and experimental neurology 57 26883114
2001 Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. Human pathology 55 11567222
2016 The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA. Molecular and cellular biology 54 27528618
1998 The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells. The Journal of cell biology 50 9722618
2021 Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour. Pathology 48 33745702
2016 Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature. The American journal of surgical pathology 48 26927892
1999 Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury. The American journal of pathology 45 10514413
2005 The nuclear exosome contributes to autogenous control of NAB2 mRNA levels. Molecular and cellular biology 44 15713618
2001 The transcriptional corepressor NAB2 blocks Egr-1-mediated growth factor activation and angiogenesis. Biochemical and biophysical research communications 44 11327726
2007 Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2. Journal of molecular biology 40 18190927
2010 Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation. The Journal of biological chemistry 39 20554526
2016 NAB2-STAT6 gene fusion and STAT6 immunoexpression in extrathoracic solitary fibrous tumors: the association between fusion variants and locations. Pathology international 38 27039712
2012 The long and the short of it: the role of the zinc finger polyadenosine RNA binding protein, Nab2, in control of poly(A) tail length. Biochimica et biophysica acta 35 22484098
2016 Clinicopathological differences between variants of the NAB2-STAT6 fusion gene in solitary fibrous tumors of the meninges and extra-central nervous system. Brain tumor pathology 34 27271270
2006 Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Journal of immunology (Baltimore, Md. : 1950) 34 17142725
2004 Epstein-Barr virus is integrated between REL and BCL-11A in American Burkitt lymphoma cell line (NAB-2). Laboratory investigation; a journal of technical methods and pathology 33 15241441
2012 Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export. Structure (London, England : 1993) 32 22560733
2004 Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function. The Journal of biological chemistry 32 15208322
2017 Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae. Nucleic acids research 28 28180315
2017 Recurrent NAB2-STAT6 gene fusions and oestrogen receptor-α expression in pulmonary adenofibromas. Histopathology 27 28072477
2016 The NAB2-STAT6 gene fusion in solitary fibrous tumor can be reliably detected by anchored multiplexed PCR for targeted next-generation sequencing. Cancer genetics 27 27292373
1996 Mader: a novel nuclear protein over expressed in human melanomas. Oncogene 27 8649813
2013 Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay. Molecular and cellular biology 25 24081329
2020 Widespread Transcriptional Readthrough Caused by Nab2 Depletion Leads to Chimeric Transcripts with Retained Introns. Cell reports 24 33113357
2016 Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene. Journal of clinical pathology 24 27802414
2015 The poly(A)-binding protein Nab2 functions in RNA polymerase III transcription. Genes & development 24 26220998
2011 Nab2 functions in the metabolism of RNA driven by polymerases II and III. Molecular biology of the cell 24 21680710
2009 Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex. RNA (New York, N.Y.) 23 19369424
2009 The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma. PloS one 23 19888474
2019 Structure-function relationships in the Nab2 polyadenosine-RNA binding Zn finger protein family. Protein science : a publication of the Protein Society 22 30578643
2012 Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2. Neoplasia (New York, N.Y.) 22 22431919
2011 Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood 21 22128144
2020 NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation. Biochemical and biophysical research communications 20 32216968
2013 Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. Journal of structural and functional genomics 20 23535894
2007 An interaction between two RNA binding proteins, Nab2 and Pub1, links mRNA processing/export and mRNA stability. Molecular and cellular biology 20 17636033
2013 Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers. Nucleic acids research 18 24071581
1997 The Nab2 and Stat6 genes share a common transcription termination region. Genomics 18 9126479
2019 Recurrent Sinonasal CD34-Negative Malignant Solitary Fibrous Tumor Diagnosed on STAT6 Immunohistochemistry and NAB2-STAT6 Fusion. Head and neck pathology 16 30623305
2012 New kid on the ID block: neural functions of the Nab2/ZC3H14 class of Cys₃His tandem zinc-finger polyadenosine RNA binding proteins. RNA biology 16 22614829
2023 Glucose stress causes mRNA retention in nuclear Nab2 condensates. Cell reports 14 38113140
2020 Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly(A)-binding protein Nab2. Nucleic acids research 14 33137177
2016 'Papillary' solitary fibrous tumor/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion. Brain tumor pathology 13 26746203
2006 FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1. Biochemical and biophysical research communications 13 17174939
2015 NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases. Brain tumor pathology 12 25893823
2015 A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion. Diagnostic pathology 12 26337721
2022 The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology. Genetics 11 34791182
2022 Teratocarcinosarcoma-Like and Adamantinoma-Like Head and Neck Neoplasms Harboring NAB2::STAT6: Unusual Variants of Solitary Fibrous Tumor or Novel Tumor Entities? Head and neck pathology 11 35303277
2015 FDG PET/CT and MR imaging of CD34-negative soft-tissue solitary fibrous tumor with NAB2-STAT6 fusion gene. Anticancer research 11 25667482
2014 Commentary on "integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer." Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T, Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.: Cancer Cell 2013;23(2):159-70. Urologic oncology 11 24445294
2013 NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells. Immunology letters 11 23416169
2013 Inversion-mediated gene fusions involving NAB2-STAT6 in an unusual malignant meningioma. British journal of cancer 11 23860521
2023 Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3. The Journal of neuroscience : the official journal of the Society for Neuroscience 10 36849419
2021 Lipomatous Solitary Fibrous Tumors Harbor Rare NAB2-STAT6 Fusion Variants and Show Up-Regulation of the Gene PPARG, Encoding for a Regulator of Adipocyte Differentiation. The American journal of pathology 10 33887215
2012 The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. European journal of immunology 10 22806638
2023 The Drosophila Nab2 RNA binding protein inhibits m6A methylation and male-specific splicing of Sex lethal transcript in female neuronal tissue. eLife 9 37458420
2020 Dbp5 associates with RNA-bound Mex67 and Nab2 and its localization at the nuclear pore complex is sufficient for mRNP export and cell viability. PLoS genetics 9 33002012
2013 Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. PloS one 9 24204683
2020 Regulation of the early growth response-1 binding protein NAB2 in bovine granulosa cells and effect on connective tissue growth factor expression. Molecular and cellular endocrinology 8 33002529
2019 Papillary Solitary Fibrous Tumor/Hemangiopericytoma: An Uncommon Morphological Form With NAB2-STAT6 Gene Fusion. Journal of neuropathology and experimental neurology 8 31271432
2016 Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma. Diagnostic pathology 8 26817999
2013 NAB2-STAT6 fusions are a hallmark of solitary fibrous tumors. Cancer discovery 8 23475888
2002 Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. Neurogenetics 8 12030330
1998 Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator mader in normal human CNS. Neuroimmunomodulation 8 9730695
2021 NAB2-STAT6 Gene Fusions to Evaluate Primary/Metastasis of Hemangiopericytoma/Solitary Fibrous Tumors. American journal of clinical pathology 7 34075396
2021 The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain. The Journal of biological chemistry 7 34139237
2021 Determination of biological behavior of solitary fibrous tumors: correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs. Neoplasma 7 34818026
2018 Solitary Fibrous Tumor of the Vulva: Report of 2 Cases, Including a De Novo Dedifferentiated Solitary Fibrous Tumor Diagnosed After Molecular Demonstration of NAB2-STAT6 Gene Fusion. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 7 28968297
2015 Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature. Case reports in pathology 7 26425382
2023 Reduction of Tumor Growth with RNA-Targeting Treatment of the NAB2-STAT6 Fusion Transcript in Solitary Fibrous Tumor Models. Cancers 6 37370737
2022 The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism. G3 (Bethesda, Md.) 6 35471546
2022 Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene. Histopathology 6 35758200
2022 Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle. Virchows Archiv : an international journal of pathology 6 36056239
2021 Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage of Malaria Parasites. Frontiers in cellular and infection microbiology 6 34604117
2017 NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response. Oncotarget 6 29464024
2024 NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors. Brain pathology (Zurich, Switzerland) 5 38523251
2021 Management of Polymicrobial Cierny-Mader Grade 3 and 4 Chronic Osteomyelitis of the Femur. Cureus 5 33628684
2020 A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in Drosophila melanogaster. G3 (Bethesda, Md.) 4 32817074
2025 NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors. eLife 3 40875449
2024 The RNA-binding protein Nab2 regulates levels of the RhoGEF Trio to govern axon and dendrite morphology. Molecular biology of the cell 3 38985523
2018 Refining the nuclear localization signal within the Egr transcriptional coregulator NAB2. FEBS letters 3 30411343
2017 The transcriptional coregulator NAB2 is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells. Oncotarget 3 29152069
2015 [Two Cases of Primary Intracranial Solitary Fibrous Tumor:Genetic Examination of NAB2-STAT6 Fusion and Its Association with Hemangiopericytoma]. No shinkei geka. Neurological surgery 3 26136329