Affinage

EGR3

Early growth response protein 3 · UniProt Q06889

Length
387 aa
Mass
42.6 kDa
Annotated
2026-06-09
100 papers in source corpus 40 papers cited in narrative 39 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EGR3 is a Cys2-His2 zinc-finger immediate-early transcription factor that binds the GC-rich consensus element CGCCCCCGC—shared with EGR1/EGR2—to activate or repress target genes in response to mitogenic, neuronal-activity, and hormonal signals (PMID:1906159, PMID:10467592). Its transcription is itself driven by signal-specific promoter inputs: an NF-AT-dependent 27-bp element confers calcineurin-sensitive induction in T cells (PMID:9819402), while NRG1 induces Egr3 in muscle through a composite SRF–CREB element via MRTF-A/B nuclear translocation and ERK1/2-dependent CREB phosphorylation (PMID:23318675, PMID:24272970). In the nervous system EGR3 is a transient activity-induced regulator that, acting sequentially with EGR1, controls late-phase transcriptional responses and is required for hippocampal LTP and learning, for activity-dependent induction of Bdnf, GABRA4, and Htr2a, and—downstream of NGF—for sympathetic neuron terminal axon and dendrite branching (PMID:9489747, PMID:16091474, PMID:17350282, PMID:23467373, PMID:29867393, PMID:35001075). In muscle EGR3 acts cell-autonomously within intrafusal myotubes as the essential transcriptional driver of muscle spindle morphogenesis and maintenance (PMID:9731539, PMID:11401400, PMID:25855173). In the immune system EGR3 (with EGR2) restrains T cell activation and autoimmunity by inducing Cbl-b, SOCS1/SOCS3, and Ltbp3/TGF-β3 while blocking Batf (PMID:15834410, PMID:23021953, PMID:27911796). EGR3 establishes a NAB2 negative-feedback loop and operates as a context-dependent activator or repressor across epidermal differentiation, cancer cell migration/metastasis, cocaine neuroplasticity in nucleus accumbens MSN subtypes, and mechanosensitive cardiac valve morphogenesis via Nr4a2b (PMID:20506119, PMID:25995477, PMID:30342896, PMID:32796959, PMID:38748804).

Mechanistic history

Synthesis pass · year-by-year structured walk · 39 steps
  1. 1991 High

    Established EGR3's molecular identity by showing it is a zinc-finger immediate-early gene that binds the same GC-rich cis element as EGR1/EGR2 and activates transcription, defining it as a sequence-specific transcriptional activator.

    Evidence CAT reporter assay, cloning, and Northern blot defining the CGCCCCCGC target element

    PMID:1906159

    Open questions at the time
    • No endogenous target genes identified at this stage
    • No tissue-specific function established
  2. 1994 High

    Placed EGR3 in neuronal activity-dependent transcription by showing rapid induction by seizure and NMDA signaling and co-expression with Egr1 at shared binding sites, raising the question of how the two EGR proteins divide labor.

    Evidence Differential cloning, EMSA DNA binding, in situ hybridization, and pharmacology in hippocampal/cortical neurons

    PMID:10467592

    Open questions at the time
    • Whether Egr1 and Egr3 compete or cooperate at targets unresolved
    • No direct downstream neuronal target identified
  3. 1998 High

    Demonstrated a non-redundant developmental role: Egr3 is essential and cell-autonomous in intrafusal myotubes for muscle spindle morphogenesis, establishing EGR3 as a developmental master regulator downstream of innervation.

    Evidence Germline knockout mice, histology, in situ hybridization, and nerve transection

    PMID:9731539

    Open questions at the time
    • Downstream transcriptional targets in myotubes not identified
    • Upstream innervation-derived signal unknown
  4. 1998 High

    Dissected signal-specific EGR3 promoter logic, showing T cell EGR3 induction depends on NF-ATp/NF-ATc binding a 27-bp element and is calcineurin/CsA-sensitive, while fibroblasts use distinct promoter inputs.

    Evidence Promoter deletion, EMSA, reporter assays, and NF-ATp overexpression rescue

    PMID:9819402

    Open questions at the time
    • Functional consequence of NF-AT-driven EGR3 in T cells not yet defined
    • Cell-type specificity mechanism only partially resolved
  5. 1998 Medium

    Resolved the EGR1/EGR3 division of labor temporally by showing Egr1 mediates the early and Egr3 the late phase of seizure-induced transcription at the shared element.

    Evidence Western blot and EMSA time courses after electroconvulsive stimulation in vivo

    PMID:9489747

    Open questions at the time
    • Single lab, in vivo only
    • Distinct late-phase target genes not yet identified
  6. 2001 High

    Refined the spindle phenotype to a postnatal differentiation/maintenance requirement, showing innervated myotubes initiate but fail to complete spindle assembly without Egr3.

    Evidence Spatiotemporal KO marker analysis, immunohistochemistry, nerve transection

    PMID:11401400

    Open questions at the time
    • Direct EGR3 target genes governing myosin/capsule formation unknown
  7. 2004 Medium

    Connected EGR3 to hormone signaling, identifying it as a primary ERα target that in turn induces NAB2 and FasL in breast cancer cells.

    Evidence Northern blot, cycloheximide/ICI 182,780, inducible EGR3, microarray, reporter assay in MCF-7

    PMID:15171706

    Open questions at the time
    • Direct promoter binding to NAB2/FasL not shown by ChIP here
    • Single lab
  8. 2005 High

    Provided first in vivo ChIP evidence of direct EGR3 target regulation, showing Egr3 binds and activates the GABRA4 promoter in hippocampus, linking EGR3 to neuronal GABA receptor expression in epilepsy.

    Evidence Reporter transfection, KO mice, ChIP, and pilocarpine seizure model

    PMID:16091474

    Open questions at the time
    • Functional impact of altered GABRA4 on seizure behavior not fully resolved
  9. 2005 High

    Defined EGR3's immune function: with EGR2 it negatively regulates T cell activation and induces anergy via the E3 ligase Cbl-b, establishing EGR3 as a tolerance-promoting factor.

    Evidence Microarray, T cell overexpression, KO mice, and in vivo tolerance assay

    PMID:15834410

    Open questions at the time
    • Direct Cbl-b promoter binding not definitively shown
    • Redundancy with Egr2 not separated
  10. 2006 Medium

    Revealed a non-transcriptional regulatory mode in thymocytes: Egr3 physically interacts with RORγt and reduces its activity to drive a proliferative phase of pre-TCR signaling.

    Evidence Genetic epistasis, proliferation assays, and protein interaction studies

    PMID:16782036

    Open questions at the time
    • Structural basis of EGR3–RORγt interaction undefined
    • Single lab
  11. 2007 High

    Separated EGR3 from EGR1 functionally in cognition, showing Egr3 is required for hippocampal LTP and memory independently of unchanged Egr1 levels.

    Evidence KO mice, LTP electrophysiology, behavioral memory tests, Egr1 Western blot

    PMID:17350282

    Open questions at the time
    • Synaptic target genes mediating the LTP defect not identified here
  12. 2008 High

    Established the NGF→Egr3 axis in sympathetic neurons required for terminal axon branching and autonomic function but not survival.

    Evidence KO mice, immunohistochemistry, autonomic physiology, NGF treatment

    PMID:18653557

    Open questions at the time
    • Neuron-autonomous vs target-tissue contribution not yet separated
    • Direct axon-guidance targets unknown
  13. 2010 Medium

    Formalized the EGR–NAB2 negative-feedback loop, showing EGR3 (like EGR1/2) activates NAB2, which represses EGR-induced transcription, and that EGR3 also regulates EGR2.

    Evidence siRNA knockdown, reporter assays, kinetic expression in melanoma/carcinoma cells

    PMID:20506119

    Open questions at the time
    • Quantitative dynamics of feedback in vivo unresolved
    • Single lab
  14. 2011 Medium

    Linked EGR3 to BDNF-driven synaptic plasticity, showing Egr3 and CREB co-regulate the NMDA NR1 subunit promoter downstream of TrkB/MAPK.

    Evidence BDNF treatment of cortical neurons, reporter assays, MAPK inhibition

    PMID:22035109

    Open questions at the time
    • Direct EGR3 binding to NR1 promoter not confirmed by ChIP
    • Single lab
  15. 2011 Medium

    Extended EGR3's direct targets to innate immunity, showing ChIP-confirmed binding to the TREM-1 promoter in monocytes.

    Evidence In silico prediction and in vivo ChIP

    PMID:21421043

    Open questions at the time
    • Single method for binding, no functional knockout
    • Downstream TREM-1 consequence not tested
  16. 2012 High

    Defined the molecular basis of EGR2/EGR3-dependent immune homeostasis, showing they directly induce SOCS1/SOCS3 to limit STAT1/STAT3 and antagonize Batf to permit AP-1 activation; their loss causes lethal autoimmunity.

    Evidence Conditional double KO, cytokine/STAT profiling, promoter analysis, ChIP

    PMID:23021953

    Open questions at the time
    • Relative EGR2 vs EGR3 contribution to each target not fully separated
  17. 2013 High

    Established the upstream NRG1 signaling logic for Egr3 induction in muscle, mapping a composite SRF–CREB promoter element controlled by MRTF-A/B translocation and ERK-dependent CREB phosphorylation.

    Evidence Promoter mutagenesis, MRTF translocation, CREB phosphorylation, ERK inhibition in muscle cells and at spindles

    PMID:23318675 PMID:24272970

    Open questions at the time
    • How this signaling couples to spindle-specific downstream targets unresolved
  18. 2013 High

    Proved a neuron-autonomous role for Egr3 in sympathetic axon/dendrite morphology and identified axonogenesis/guidance target genes via microarray.

    Evidence Neuron-specific Cre KO, primary culture with NGF, microarray, genetic labeling

    PMID:23467373

    Open questions at the time
    • Direct vs indirect status of microarray targets not ChIP-validated
  19. 2014 Medium

    Reported an unexpected cytoplasmic localization of Egr3 at meiotic spindle/MTOCs in oocytes, while showing it does not directly bind microtubules, indicating an indirect MTOC association distinct from its nuclear role.

    Evidence Immunofluorescence, γ-tubulin co-localization, nocodazole, in vitro microtubule binding assay

    PMID:24722338

    Open questions at the time
    • Functional significance of MTOC association unknown
    • Mediator of indirect association unidentified
  20. 2014 Medium

    Showed Egr3 gain-of-function biases thymocytes toward γδ T cell development and promotes Th17 differentiation, expanding its immune developmental role.

    Evidence Egr3 transgenic mice, flow cytometry, differentiation and co-culture assays, bleomycin model

    PMID:24475259

    Open questions at the time
    • Loss-of-function requirement not tested
    • Direct targets in γδ lineage unknown
  21. 2015 High

    Definitively localized the spindle requirement to muscle by cell-specific ablation, showing Egr3 loss produces spindle remnants lacking GDNF and fusimotor innervation but retaining NT3 and Ia-afferent contact.

    Evidence Muscle-specific conditional KO, lineage tracing, MyHC/NT3/GDNF immunohistochemistry

    PMID:25855173

    Open questions at the time
    • Whether GDNF is a direct EGR3 target not shown
  22. 2015 High

    Revealed cell-type-opposing functions in addiction, showing cocaine induces Egr3 in D1-MSNs and reduces it in D2-MSNs with opposite behavioral consequences, and altered Egr3 binding at numerous plasticity gene promoters.

    Evidence RiboTag transcriptomics, Cre-inducible AAV manipulation, D1/D2-Cre mice, ChIP

    PMID:25995477

    Open questions at the time
    • Mechanism of opposite D1 vs D2 regulation unresolved
  23. 2015 Medium

    Identified Egr3 as required for sleep-deprivation-induced cortical Htr2a expression, linking it to serotonergic regulation.

    Evidence KO mice, sleep deprivation, Htr2a qPCR

    PMID:25857407

    Open questions at the time
    • Direct promoter binding not shown in this study
    • Behavioral consequence not tested
  24. 2016 High

    Defined an Egr2/Egr3-Ltbp3-TGF-β3 axis in regulatory T cells preventing humoral autoimmunity, with double KO ablating TGF-β3 production.

    Evidence T cell-specific double KO, adoptive transfer, TGF-β3 vector rescue, Ltbp3 analysis

    PMID:27911796

    Open questions at the time
    • Direct Ltbp3 promoter binding not detailed
    • EGR3-only contribution not isolated
  25. 2016 Medium

    Showed Egr3 promotes myoblast proliferation and survival via NF-κB activity and suppression of caspase-dependent apoptosis.

    Evidence shRNA in C2C12, NF-κB reporter, apoptosis assays, caspase-inhibitor rescue

    PMID:27576048

    Open questions at the time
    • Direct EGR3 targets in NF-κB/apoptosis pathway not mapped
    • Single cell-line system
  26. 2017 Medium

    Established post-transcriptional control of EGR3, showing KSRP-driven miR-23a destabilizes EGR3 mRNA and that EGR3 promotes NSCLC migration and metastasis.

    Evidence KSRP manipulation, miRNA screening, 3'UTR reporter, in vivo metastasis

    PMID:28847731

    Open questions at the time
    • EGR3 transcriptional targets driving metastasis here not identified
    • Single lab
  27. 2018 Medium

    Identified Bdnf as an Egr3-dependent activity-induced gene, showing seizure-induced Bdnf induction (exons IV/VI) is absent in Egr3-/- hippocampus.

    Evidence KO mice, ECS, microarray, qRT-PCR, in situ, promoter bioinformatics

    PMID:29867393

    Open questions at the time
    • Promoter binding not confirmed by ChIP here
    • Direct vs indirect regulation unresolved
  28. 2018 High

    Defined a tissue-differentiation role outside neurons and immunity, showing EGR3 drives late epidermal differentiation enhancers and the epidermal differentiation complex, with loss in parakeratotic skin.

    Evidence Immunohistochemistry, RNA-seq, ChIP-seq, enhancer RNA, co-expression analysis

    PMID:30342896

    Open questions at the time
    • Upstream signals inducing epidermal EGR3 not defined
  29. 2019 Medium

    Revealed sex-specific EGR3 regulation of cocaine relapse, with female-specific EGR3 reduction after abstinence and opposite behavioral effects of D2-MSN overexpression between sexes.

    Evidence Cocaine self-administration, EGR3 Western blot, A2A-Cre Egr3 overexpression, operant behavior

    PMID:31858986

    Open questions at the time
    • Molecular basis of sex specificity unknown
    • Single lab
  30. 2020 High

    Defined a tumor-suppressive EGR3 program in prostate cancer, with direct activation of ZFP36, GADD45B, and SOCS3, suppression of EMT/invasion, and reduced bone metastasis.

    Evidence ChIP, luciferase, overexpression/knockdown, mouse bone metastasis model

    PMID:32796959

    Open questions at the time
    • Context-dependent oncogenic vs suppressive roles across cancers not reconciled
  31. 2020 Medium

    Identified RELN as a direct EGR3 target mediating its inhibition of neurite outgrowth, providing an epistatic neuronal pathway.

    Evidence ChIP, reporter assay, overexpression/RELN knockdown rescue in SH-SY5Y, microarray/IPA

    PMID:33113163

    Open questions at the time
    • In vivo relevance not tested
    • Single cell-line system
  32. 2020 Medium

    Linked EGR3 to cardiac fibrosis as a pro-fibrotic TGF-β-promoting factor repressed by miR-27a-5p.

    Evidence Luciferase 3'UTR validation, TAC model, miR-27a KO/inhibition, cardiac fibroblast culture

    PMID:33215816

    Open questions at the time
    • Direct EGR3 transcriptional targets in fibrosis not mapped
    • Single lab
  33. 2021 High

    Established an NF-κB→EGR3→HDAC6→IL-27 axis driving mast cell-dependent allergic inflammation, with miR-182-5p as a negative regulator.

    Evidence RNA-seq, ChIP for p65/EGR3, luciferase for miR-182-5p, anaphylaxis models

    PMID:34234781

    Open questions at the time
    • Generalizability of HDAC6 axis to other immune contexts unclear
  34. 2021 Medium

    Connected EGR3 to mitochondrial dynamics in addiction, showing cocaine enhances Egr3 binding at PGC1α/Drp1 promoters in D1-MSNs to remodel mitochondrial morphology.

    Evidence ChIP in NAc, D1-MSN Egr3 knockdown, mRNA quantification, EM morphology

    PMID:34187517

    Open questions at the time
    • Direct vs indirect promoter regulation incompletely separated
    • Single lab
  35. 2022 High

    Confirmed Htr2a as a direct in vivo EGR3 target through ChIP and reporter site mutagenesis, mechanistically grounding the sleep-deprivation/serotonin link.

    Evidence KO mice, sleep deprivation, in vivo ChIP, reporter with binding-site mutations, qPCR/protein

    PMID:35001075

    Open questions at the time
    • Behavioral/psychiatric consequence of the EGR3–5-HT2AR axis not fully defined
  36. 2022 Medium

    Broadened the activity-dependent EGR3 gene program to DNA-damage-response and AP-1 family genes (Gadd45b/g, Fos, Fosb, Mef2c, Calb2) after seizure.

    Evidence Hippocampal microarray of WT vs Egr3-/- after ECS, pathway analysis

    PMID:35941129

    Open questions at the time
    • Direct binding to these promoters not validated
    • Functional consequences not tested
  37. 2023 Medium

    Identified an EGR3–MCL1 axis conferring tamoxifen resistance in ERα+ breast cancer by suppressing apoptosis, with estrone upregulating EGR3.

    Evidence ChIP, dual luciferase, overexpression/knockdown, apoptosis assays, Western blot

    PMID:37999751

    Open questions at the time
    • Clinical relevance to patient resistance not established
    • Single lab
  38. 2024 High

    Defined EGR3 as a conserved mechanosensitive endothelial transcription factor essential for cardiac valve morphogenesis, acting cell-autonomously via Nr4a2b, validated across zebrafish, porcine, and human systems.

    Evidence egr3 null zebrafish, tissue-specific tools, live imaging, mechanostimulation of valvular endothelial cells

    PMID:38748804

    Open questions at the time
    • Mechanotransduction pathway linking force to EGR3 induction not fully mapped
  39. 2024 Medium

    Established EGR3 as a cortisol-repressed negative regulator of adipogenesis acting via HDAC6.

    Evidence Overexpression/knockdown in hADSCs and 3T3-L1, cortisol treatment, ChIP/reporter of HDAC6

    PMID:38467615

    Open questions at the time
    • In vivo metabolic phenotype of EGR3 manipulation not established
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How EGR3 selects opposite activator vs repressor outcomes and cell-type-specific target sets across its diverse contexts (D1 vs D2 neurons, oncogenic vs tumor-suppressive cancer roles) remains unresolved.
  • No unifying determinant of EGR3 activator/repressor switching identified
  • Cofactor-dependent target selection mechanism unknown
  • No structural model of EGR3-cofactor complexes

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8 GO:0003677 DNA binding 7
Localization
GO:0005634 nucleus 4 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1266738 Developmental Biology 4 R-HSA-168256 Immune System 4 R-HSA-112316 Neuronal System 3
Partners
CREB1NAB2RORCSRF

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 EGR3 encodes a 387 amino acid zinc-finger transcription factor with three Cys2-His2 zinc fingers that can activate transcription of a CAT reporter gene linked to the cis element CGCCCCCGC, the same target sequence recognized by EGR1 and EGR2. EGR3 is induced as an immediate-early gene by mitogenic stimulation. CAT reporter assay, low-stringency hybridization cloning, Northern blot Oncogene High 1906159
1994 Egr3/Pilot is rapidly and transiently induced in hippocampal and cortical neurons by electroconvulsive seizure, NMDA receptor activation, and dopamine-altering drugs; it binds the same consensus DNA sequence as Egr1/zif268 and the two proteins are co-expressed in the same neurons, suggesting competitive or cooperative transcriptional regulation at shared target sites. Differential cDNA cloning, Northern blot, gel shift (EMSA) for DNA binding, in situ hybridization, pharmacological manipulations Learning & Memory High 10467592
1998 Egr3 is essential for muscle spindle morphogenesis: Egr3-deficient mice lack muscle spindles entirely. Egr3 is expressed specifically in developing intrafusal myotubes (not in Ia afferent neurons) after innervation by sensory afferents, indicating that Egr3-mediated transcription in myotubes is required for spindle induction. Gene targeting (knockout mice), histology, in situ hybridization, nerve transection experiments Nature Genetics High 9731539
1998 EGR3 expression in T cells (but not fibroblasts) is driven by a 27-bp promoter element that binds NF-ATp and NF-ATc, making it sensitive to cyclosporin A (CsA) inhibition of calcineurin/NF-AT signaling. In fibroblasts, different CsA-insensitive promoter regions drive EGR3 expression, and insufficient NF-ATp levels explain the lack of this element's activity there. Promoter deletion analysis, EMSA, transient transfection reporter assays, NF-ATp overexpression in fibroblasts Molecular and Cellular Biology High 9819402
1998 Following electroconvulsive stimulation in hippocampal granule cells, Egr1 protein peaks at 0.5–1 h and decays by 4 h, whereas Egr3 protein peaks at 4 h; their DNA-binding activities follow the same sequential pattern, indicating they mediate early and late phases, respectively, of transcriptional responses at their shared consensus element. Western blot, gel shift assay (EMSA), electroconvulsive stimulation in vivo Journal of Neurochemistry Medium 9489747
2001 Egr3 is required for intrafusal fiber differentiation and spindle maintenance after birth: in Egr3-deficient mice, myotubes are initially innervated by Ia afferents and begin spindle assembly, but fail to express slow-developmental myosin heavy chain, form thin capsules, and after birth the sensory and motor innervation withdraws and spindles disassemble. Egr3 expression in myotubes is controlled by innervation (lost after nerve transection). Egr3 KO analysis, immunohistochemistry, in situ hybridization, nerve transection Developmental Biology High 11401400
2004 EGR3 is a direct transcriptional target of estrogen receptor alpha (ERα) in breast cancer MCF-7 cells; EGR3 in turn transcriptionally induces NAB2 and FasL. Cycloheximide and ICI 182,780 (ERα antagonist) block EGR3 induction, confirming it is a primary ERα target. Northern blot, cycloheximide/ICI 182,780 treatment, stable transfection with inducible EGR3, microarray, reporter assay Journal of Molecular Endocrinology Medium 15171706
2005 Egr3 directly up-regulates GABRA4 promoter activity in hippocampal neurons, and Egr3 knockout mice have ~50% less GABRA4 mRNA in hippocampus. After pilocarpine-induced status epilepticus, Egr3 binds to the GABRA4 promoter (shown by ChIP) and both GABRA4 and alpha4 subunit protein are increased, establishing Egr3 as a transcriptional regulator of GABRA4 in epilepsy. Reporter gene transfection in primary hippocampal neurons, Egr3 KO mice, ChIP, in vivo seizure model PNAS High 16091474
2005 Egr2 and Egr3 function as negative regulators of T cell activation and promote anergy by inducing expression of the E3 ubiquitin ligase Cbl-b. Egr3-deficient T cells have reduced Cbl-b expression and are resistant to peptide-induced tolerance in vivo. Microarray, overexpression in T cells, Egr3 KO mice, in vivo tolerance assay Nature Immunology High 15834410
2006 Egr3 is transiently induced by pre-TCR signaling in thymocytes and promotes a distinct proliferative phase by reducing E protein-dependent RORγt expression and physically interacting with RORγt to prevent induction of RORγt target genes. After Egr3 levels subside, RORγt activity increases to promote gene rearrangement. Genetic epistasis (RORγt, Egr3, E protein manipulation), thymocyte proliferation assays, protein interaction studies Immunity Medium 16782036
2007 Egr3 is required for normal hippocampal long-term potentiation (LTP) — both early and late phase — and for hippocampal and amygdala-dependent short-term and long-term learning and memory, independently of Egr1 (Egr1 protein levels are unchanged in Egr3 KO brain). Egr3 KO mice, electrophysiological LTP recordings, behavioral memory tests (fear conditioning, etc.), Western blot for Egr1 Molecular and Cellular Neurosciences High 17350282
2008 Egr3 is induced by NGF signaling in sympathetic neurons and is required for their normal terminal axon extension and branching in target tissues, but not for neuron survival. Egr3-deficient mice have severe sympathetic target tissue innervation abnormalities and physiological dysautonomia. Egr3 KO mice, immunohistochemistry, physiological autonomic function assays, NGF treatment Development High 18653557
2010 EGR1, EGR2, and EGR3 all activate NAB2 transcription through similar cis-regulatory elements in melanoma and carcinoma cells, establishing a negative feedback loop (NAB2 represses EGR-induced transcription). EGR3 depletion by siRNA reduces endogenous NAB2 levels; EGR3 also regulates EGR2 expression. siRNA knockdown, reporter assays, kinetic expression studies Journal of Cellular Biochemistry Medium 20506119
2011 BDNF increases NMDA receptor NR1 subunit levels in cortical neurons via MAPK pathway activation of TrkB, and this NR1 transcription is controlled by binding of both CREB and Egr3 to the core NR1 promoter region. BDNF treatment of rat cortical neurons, reporter assays, MAPK pathway inhibition, protein expression analysis Journal of Neurochemistry Medium 22035109
2011 EGR3 binds to the promoter of TREM-1 in monocytes as demonstrated by ChIP, indicating that EGR3 directly regulates TREM-1 gene expression. In silico binding site prediction and in vivo ChIP assay Brain, Behavior, and Immunity Medium 21421043
2012 Deletion of both Egr2 and Egr3 in lymphocytes causes lethal autoimmunity with hyperactive STAT1/STAT3 and impaired antigen receptor-induced AP-1 activation. Egr2 and/or Egr3 directly induce expression of SOCS1 and SOCS3 (inhibitors of STAT1/STAT3), and block function of Batf (an AP-1 inhibitor). Conditional double KO mice, cytokine profiling, STAT phosphorylation assays, promoter analysis, ChIP Immunity High 23021953
2013 Egr3 has a sympathetic neuron-autonomous role: isolated Egr3-deficient sympathetic neurons have neurite outgrowth defects in response to NGF, and neuron-specific Egr3 ablation recapitulates the target tissue innervation abnormalities of germline KO. Microarray identified target genes involved in axonogenesis, dendritogenesis, and axon guidance; Egr3 specifically regulates dendrite morphology and terminal axon branching. Cre-mediated sympathetic neuron-specific KO, primary neuron culture with NGF, microarray, genetic neuronal labeling Journal of Neuroscience High 23467373
2013 NRG1 signaling induces Egr3 transcription in muscle cells through a composite SRF-CREB regulatory element in the Egr3 promoter. NRG1 targets SRF by stimulating nuclear translocation of MRTF-A and MRTF-B coactivators, and phosphorylates CREB. The Erk1/2 MAP kinase is required upstream of CREB phosphorylation for NRG1-induced Egr3 transcription. Reporter assays with promoter deletions/mutations, MRTF nuclear translocation assays, CREB phosphorylation assays, ERK inhibition in cultured muscle cells and in vivo immunostaining at spindles Experimental Cell Research / Journal of Neuroscience Research High 23318675 24272970
2014 Egr3 protein co-localizes with the meiotic spindle and cytosolic microtubule organizing centers (MTOCs) in mouse oocytes, accumulating around γ-tubulin. Nocodazole-induced microtubule depolymerization disrupts Egr3 localization. However, in vitro microtubule interaction assay showed Egr3 does NOT directly bind polymerized microtubules, suggesting an indirect association with MTOCs. Immunofluorescence with Egr3-specific antibodies, co-localization with γ-tubulin, nocodazole treatment, in vitro microtubule binding assay PloS One Medium 24722338
2014 Egr3 promotes γδ T cell development in the thymus: Egr3 transgenic (overexpressing) mice show a marked increase in peripheral γδ T cells, and thymocytes from these mice are biased toward γδ T cell development. Egr3-induced γδ T cells promote Th17 differentiation when co-cultured with wildtype CD4+ T cells. Egr3 transgenic mice, flow cytometry, thymocyte differentiation assays, co-culture experiments, bleomycin lung inflammation model PloS One Medium 24475259
2015 Egr3 has a skeletal muscle cell-autonomous role in intrafusal fiber differentiation: cell-specific Egr3 ablation in muscle blocks myotube development after Ia-afferent contact, producing shortened 'spindle remnants' that lack fusimotor innervation and fail to express GDNF (required for fusimotor neuron survival), but retain NT3 expression and Ia-afferent innervation. Conditional (muscle-specific) Egr3 KO, genetic lineage tracing, immunohistochemistry for MyHC, NT3, GDNF Journal of Neuroscience High 25855173
2015 Egr3 has opposing roles in nucleus accumbens MSN subtypes in cocaine action: repeated cocaine induces Egr3 in D1-MSNs and reduces it in D2-MSNs. Overexpression of Egr3 in D1-MSNs enhances cocaine reward and locomotion, while overexpression in D2-MSNs blunts these behaviors. Cocaine alters Egr3 binding to promoters of downstream genes including Camk2α, CREB, FosB, Nr4a2, Sirt1 (increased binding in D1-MSNs) and G9a, Dnmt3a (decreased binding). RiboTag cell-type-specific transcriptomics, Cre-inducible AAV overexpression/knockdown, D1-Cre and D2-Cre mice, ChIP Journal of Neuroscience High 25995477
2015 Egr3 is required for sleep-deprivation-induced expression of Htr2a (serotonin 2A receptor) in mouse cortex: sleep deprivation induces a 2-fold increase in Htr2a mRNA in wildtype but not Egr3-/- mice. Egr3 KO mice, sleep deprivation, qPCR for Htr2a mRNA ACS Chemical Neuroscience Medium 25857407
2016 Egr2 and Egr3 in T cells cooperatively prevent humoral autoimmunity by supporting TGF-β3 secretion from CD4+CD25-LAG3+ regulatory T cells. Egr2 and Egr3 maintain expression of Ltbp3 (latent TGF-β binding protein 3), which is required for TGF-β3 production; Egr2/3 double KO completely ablates TGF-β3 production from these cells. T cell-specific Egr2/Egr3 double KO mice, adoptive transfer, TGF-β3-expressing vector treatment, Ltbp3 expression analysis PNAS High 27911796
2016 Egr3 promotes myoblast proliferation and survival: shRNA inhibition of Egr3 in C2C12 cells impairs proliferation rate, reduces NF-κB transcriptional activity, increases apoptotic markers (annexin V+, caspase-3/7, PARP), and the proliferation deficit is partially rescued by pan-caspase inhibitor Z-VAD-FMK. shRNA knockdown in C2C12 cells, NF-κB reporter assay, apoptosis assays (annexin V, caspase activity), caspase inhibitor rescue Journal of Cellular Physiology Medium 27576048
2017 KSRP decreases EGR3 mRNA stability in an ARE-independent manner via miR-23a: KSRP facilitates miR-23a biogenesis, miR-23a directly binds EGR3 3'UTR reducing EGR3 expression, and EGR3 acts downstream of KSRP to promote NSCLC cell mobility and metastasis. KSRP overexpression/knockdown in NSCLC cells, microarray, miRNA screening, 3'UTR reporter assay, in vivo metastasis model Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Medium 28847731
2018 Egr3 is required for ECS-induced hippocampal expression of Bdnf: ECS induces high-level Bdnf expression in WT hippocampus (including exons IV and VI), but this induction is absent in Egr3-/- mice. The Bdnf promoter contains eight putative EGR3 binding sites, suggesting direct regulation. Egr3 KO mice, ECS, expression microarray, qRT-PCR, in situ hybridization, Bdnf promoter bioinformatics Frontiers in Behavioral Neuroscience Medium 29867393
2018 EGR3 is a transcriptional regulator of late epidermal differentiation: EGR3 is highly expressed in the stratum granulosum, activates enhancers and drives expression of genes in the epidermal differentiation complex (including filaggrin, loricrin, involucrin targets), and 20 EGR3-specific late differentiation targets were identified. EGR3 expression is lost in parakeratotic lesional skin. Immunohistochemistry, RNA-seq, ChIP-seq for enhancer analysis, enhancer RNA detection, weighted gene co-expression network analysis Journal of Investigative Dermatology High 30342896
2019 EGR3 sex-specifically regulates cocaine relapse: EGR3 protein is reduced only in female rodents after 20 days of forced abstinence from cocaine self-administration. Egr3 overexpression in NAc D2-MSNs during forced abstinence facilitates extinction and blunts drug-induced reinstatement in female mice but has the opposite effect in male mice. Intravenous cocaine self-administration, Western blot for EGR3 protein, virally mediated Egr3 overexpression via A2A-Cre, operant behavioral testing Biological Psychiatry Medium 31858986
2020 EGR3 transcriptionally activates ZFP36, GADD45B, and SOCS3 by directly binding to their promoter regions, and suppresses EMT and cell migration/invasion in prostate cancer cells; EGR3 overexpression suppresses bone metastasis in mouse models. ChIP assay, luciferase reporter assay, EGR3 overexpression/knockdown in prostate cancer cells, mouse bone metastasis model Oncogene High 32796959
2020 EGR3 directly binds the RELN (Reelin) promoter and activates RELN expression; EGR3 overexpression reduces neurite outgrowth in SH-SY5Y cells, an effect partially reversed by RELN knockdown, placing RELN downstream of EGR3 in neurite outgrowth regulation. ChIP, luciferase reporter assay, EGR3 overexpression/RELN knockdown in SH-SY5Y cells, neurite outgrowth quantification, microarray + IPA Journal of Neurochemistry Medium 33113163
2020 miR-27a-5p inhibits cardiac fibrosis by suppressing EGR3 expression: miR-27a-5p targets EGR3 3'UTR (validated by reporter assay), and EGR3 suppression reduces TGF-β signaling and pro-fibrotic protein secretion in cardiac fibroblasts. In vivo, miR-27a-5p attenuates TAC-induced cardiac fibrosis. In silico Venn analysis, luciferase reporter assay, TAC mouse model, miR-27a KO and antisense inhibition, cardiac fibroblast culture Journal of Cellular and Molecular Medicine Medium 33215816
2021 EGR3 is necessary for allergic inflammation: NF-κB p65 directly regulates EGR3 expression (binding to EGR3 promoter), and EGR3 in turn directly binds the HDAC6 promoter to increase HDAC6 expression, forming an EGR3-HDAC6-IL-27 signaling axis that mediates mast cell-dependent allergic responses and passive anaphylaxis. miR-182-5p is a direct negative regulator of EGR3 (validated by luciferase assay). RNA-seq, ChIP for NF-κB p65 on EGR3 promoter, ChIP for EGR3 on HDAC6 promoter, luciferase assay for miR-182-5p/EGR3 interaction, passive cutaneous and systemic anaphylaxis models Frontiers in Immunology High 34234781
2021 Cocaine exposure enhances Egr3 binding to promoters of nuclear genes involved in mitochondrial dynamics (PGC1α, Drp1) in D1-MSNs; blunting Egr3 in D1-MSNs blocks cocaine-mediated enhancement of PGC1α and Drp1 expression and attenuates cocaine-induced enhancement of small-sized mitochondria. ChIP in NAc tissue, virally mediated Egr3 knockdown in D1-MSNs, mRNA quantification, mitochondrial morphology analysis (electron microscopy) Molecular Brain Medium 34187517
2022 EGR3 directly regulates Htr2a (5-HT2AR) expression: ChIP in mouse frontal cortex demonstrated EGR3 protein binding to the Htr2a promoter in vivo, and EGR3 drives Htr2a reporter expression via two EGR3 binding sites. Sleep deprivation-induced upregulation of 5-HT2AR requires Egr3, as it does not occur in Egr3-/- mice. Egr3 KO mice, sleep deprivation, ChIP in vivo, luciferase reporter assay with EGR3 binding site mutations, qPCR and protein quantification Molecular Psychiatry High 35001075
2022 Egr3 is required for activity-dependent expression of DNA damage response genes (Gadd45b, Gadd45g) and AP-1 family genes (Fos, Fosb), as well as Mef2c and Calb2, in the hippocampus following ECS. These genes are differentially expressed between WT and Egr3-/- mice after seizure. Expression microarray on hippocampi of WT vs Egr3-/- mice after ECS, bioinformatics/Enrichr pathway analysis Translational Psychiatry Medium 35941129
2023 EGR3 directly binds to the MCL1 promoter to activate its transcription, and this EGR3-MCL1 axis confers tamoxifen resistance in ERα-positive breast cancer cells by suppressing apoptosis. Estrone upregulates EGR3 expression in tamoxifen-resistant cells. ChIP, dual luciferase assay, EGR3 overexpression/knockdown, apoptosis assays (CCK8, colony formation, flow cytometry), Western blot Journal of Cancer Research and Clinical Oncology Medium 37999751
2024 EGR3 functions as a conserved mechanosensitive transcription factor required for cardiac valve morphogenesis: egr3 null zebrafish completely lack valve leaflets, leading to blood regurgitation. EGR3 acts cell-autonomously in endothelial cells, and one downstream effector is the nuclear receptor Nr4a2b. Mechanical forces upregulate egr3/EGR3 expression in zebrafish heart, porcine valvular endothelial cells, and during human aortic valve remodeling. egr3 null zebrafish (CRISPR), tissue-specific loss- and gain-of-function tools, live imaging of valve morphogenesis, in vitro mechanostimulation of porcine valvular endothelial cells Science Advances High 38748804
2024 EGR3 negatively regulates adipogenesis: EGR3 is downregulated by cortisol in adipose tissue of obese subjects and high-fat-diet mice. EGR3 suppresses adipogenesis and lipogenesis in hADSCs and 3T3-L1 cells via transcriptional regulation of HDAC6 (a downstream target gene and negative regulator of adipogenesis). EGR3 overexpression/knockdown in hADSCs and 3T3-L1 cells, cortisol treatment, ChIP/reporter analysis of HDAC6 as EGR3 target Cell Death Discovery Medium 38467615

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Egr-2 and Egr-3 are negative regulators of T cell activation. Nature immunology 353 15834410
2015 A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis. The New England journal of medicine 283 26332545
1998 Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nature genetics 236 9731539
1991 EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene 220 1906159
2012 The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells. Immunity 157 23021953
2007 Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 143 17360599
2007 Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory. Molecular and cellular neurosciences 103 17350282
2018 A pilot study of durvalumab and tremelimumab and immunogenomic dynamics in metastatic breast cancer. Oncotarget 102 29721177
2015 Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action. The Journal of neuroscience : the official journal of the Society for Neuroscience 101 25995477
2019 Blood Microbiome Profile in CKD : A Pilot Study. Clinical journal of the American Society of Nephrology : CJASN 93 30962186
2006 Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals. Immunity 90 16782036
2004 Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. Journal of molecular endocrinology 87 15171706
2005 Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression. Proceedings of the National Academy of Sciences of the United States of America 86 16091474
1994 Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268. Learning & memory (Cold Spring Harbor, N.Y.) 79 10467592
2001 The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis. Developmental biology 70 11401400
2017 A Pilot Characterization of the Human Chronobiome. Scientific reports 68 29215023
2010 EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin. Journal of cellular biochemistry 66 20506119
2011 TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. Brain, behavior, and immunity 59 21421043
2011 Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. Journal of neurochemistry 59 22035109
2016 Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production. Proceedings of the National Academy of Sciences of the United States of America 53 27911796
2017 Early growth response 2 and Egr3 are unique regulators in immune system. Central-European journal of immunology 47 28860938
2011 MreB: pilot or passenger of cell wall synthesis? Trends in microbiology 47 22154164
1998 Sequential expression of Egr-1 and Egr-3 in hippocampal granule cells following electroconvulsive stimulation. Journal of neurochemistry 46 9489747
2018 Losartan ointment relieves hypertrophic scars and keloid: A pilot study. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 43 30099811
2015 Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis. The Journal of neuroscience : the official journal of the Society for Neuroscience 43 25855173
2015 Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk. PloS one 42 26474411
2008 Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice. Development (Cambridge, England) 42 18653557
2017 KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer. Biochimica et biophysica acta. Gene regulatory mechanisms 41 28847731
2016 Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity. Rheumatology (Oxford, England) 35 27856665
2010 EGR3 as a potential susceptibility gene for schizophrenia in Korea. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 35 20687139
2022 Biome-microbiome interactions in peri-implantitis: A pilot investigation. Journal of periodontology 34 35073418
2024 Use of EMPAgliflozin in the prevention of CARDiotoxicity: the EMPACARD - PILOT trial. Cardio-oncology (London, England) 33 39237985
2013 A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. The Journal of neuroscience : the official journal of the Society for Neuroscience 32 23467373
2020 Loss of EGR3 is an independent risk factor for metastatic progression in prostate cancer. Oncogene 30 32796959
2019 Immune expression in children with Wilms tumor: a pilot study. Journal of pediatric urology 30 30981637
2016 Candidate gene polymorphisms and risk of psoriasis: A pilot study. Experimental and therapeutic medicine 30 27073425
2012 A pilot characterization of human lung NSCLC by protein pathway activation mapping. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 30 23154546
2021 XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis. BMC pulmonary medicine 29 34243729
1990 Pilot- and process-scale techniques for cell disruption. Biotechnology and applied biochemistry 26 2092722
2023 Endometrial microbiota in women with and without adenomyosis: A pilot study. Frontiers in microbiology 24 36744089
2013 Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals. NeuroImage 24 23962955
2020 Serum protein biomarkers for juvenile dermatomyositis: a pilot study. BMC rheumatology 23 33015544
2019 Penta-O-galloyl-β-D-glucose from Paeonia lactiflora Pall. root extract enhances the expression of skin barrier genes via EGR3. Journal of ethnopharmacology 23 31655148
2015 Htr2a Expression Responds Rapidly to Environmental Stimuli in an Egr3-Dependent Manner. ACS chemical neuroscience 23 25857407
2022 A randomized controlled pilot trial of anakinra for hemodialysis inflammation. Kidney international 22 35863559
2019 Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration. Biological psychiatry 22 31858986
2016 Early Growth Response 3 (Egr3) Contributes a Maintenance of C2C12 Myoblast Proliferation. Journal of cellular physiology 22 27576048
2015 Injectable intraocular telescope: Pilot study. Journal of cataract and refractive surgery 22 26703288
2014 Pilot the pulse: controlling the multiplicity of receptor dynamics. Trends in pharmacological sciences 22 25455830
2012 Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. PloS one 22 22276163
2023 Detection of PatIent-Level distances from single cell genomics and pathomics data with Optimal Transport (PILOT). Molecular systems biology 21 38177382
2021 EGR3-HDAC6-IL-27 Axis Mediates Allergic Inflammation and Is Necessary for Tumorigenic Potential of Cancer Cells Enhanced by Allergic Inflammation-Promoted Cellular Interactions. Frontiers in immunology 21 34234781
2018 PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study. BMC cancer 21 29898687
2013 Egr2 and Egr3 are the unique regulators for systemic autoimmunity. JAK-STAT 21 24058814
2021 Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation. Molecular brain 20 34187517
2018 The Immediate Early Gene Egr3 Is Required for Hippocampal Induction of Bdnf by Electroconvulsive Stimulation. Frontiers in behavioral neuroscience 20 29867393
2017 Transcriptomics and methylomics in chronic periodontitis with tobacco use: a pilot study. Clinical epigenetics 20 28811843
2013 Human SLC26A1 gene variants: a pilot study. TheScientificWorldJournal 20 24250268
2004 Leukotrienes and isocyanate-induced asthma: a pilot study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20 15544591
1998 Utilization of an NF-ATp binding promoter element for EGR3 expression in T cells but not fibroblasts provides a molecular model for the lymphoid cell-specific effect of cyclosporin A. Molecular and cellular biology 20 9819402
2020 Hepatotoxicity of nutmeg: A pilot study based on metabolomics. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 19 33152938
2001 Metabolic changes and myocardial injury during cardioplegia: a pilot study. The Annals of thoracic surgery 19 11722045
2022 Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3. Molecular psychiatry 18 35001075
2020 A pilot clinical trial with losartan in Myhre syndrome. American journal of medical genetics. Part A 18 33369056
2018 EGR3 Is a Late Epidermal Differentiation Regulator that Establishes the Skin-Specific Gene Network. The Journal of investigative dermatology 18 30342896
2021 Sputum Protein Biomarkers in Airway Diseases: A Pilot Study. International journal of chronic obstructive pulmonary disease 17 34349506
2006 Is there a pilot in a pseudopod? European journal of cell biology 17 16781010
1996 Thiopurine methyltransferase: a review and a clinical pilot study. Journal of chromatography. B, Biomedical applications 17 8861653
2023 Posthospital Multidisciplinary Care for AKI Survivors: A Feasibility Pilot. Kidney medicine 16 37964784
2022 Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia. Translational psychiatry 16 35941129
2020 De novo mutations in idiopathic male infertility-A pilot study. Andrology 16 32860660
2018 EGR3 Immediate Early Gene and the Brain-Derived Neurotrophic Factor in Bipolar Disorder. Frontiers in behavioral neuroscience 16 29459824
2018 Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice. Journal of biological rhythms 16 30318979
2017 A pilot study on corneal Langerhans cells in keratoconus. Contact lens & anterior eye : the journal of the British Contact Lens Association 16 29066264
2006 Pilot study of mucosal genetic differences in early smokers and nonsmokers. The Laryngoscope 16 16885739
2024 egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. Science advances 15 38748804
2024 Scaling CO2 Electrolyzer Cell Area from Bench to Pilot. ACS applied materials & interfaces 15 39254196
2021 Nuclear lipidome is altered in amyotrophic lateral sclerosis: A pilot study. Journal of neurochemistry 15 33905537
2020 Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro. Journal of neurochemistry 15 33113163
2014 Association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China. Lipids in health and disease 15 24886494
2009 Reflections on some pilot trials of gastrin receptor blockade in pancreatic cancer. European journal of cancer (Oxford, England : 1990) 15 19131241
2020 Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3). Journal of cellular and molecular medicine 14 33215816
2004 Prevalence of the sickle cell gene in Yemen: a pilot study. Hemoglobin 14 15658186
2024 Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway. Cell death discovery 13 38467615
2016 Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits. Sleep 13 28057087
2014 Egr3 induces a Th17 response by promoting the development of γδ T cells. PloS one 13 24475259
2013 Neuregulin1 signaling targets SRF and CREB and activates the muscle spindle-specific gene Egr3 through a composite SRF-CREB-binding site. Experimental cell research 13 23318675
2024 A pilot oral history of plant synthetic biology. Plant physiology 12 38163646
2014 AnaLysis of Expression on human chromosome 21, ALE-HSA21: a pilot integrated web resource. Database : the journal of biological databases and curation 12 24573881
2014 The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes. PloS one 12 24722338
2023 TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study. American journal of clinical pathology 11 37565763
2021 Overexpression of miR-874-3p alleviates LPS-induced apoptosis and inflammation in alveolar epithelial cell by targeting EGR3/NF-κB. Acta biochimica Polonica 11 34038062
2017 Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3. Neural plasticity 11 28589041
2013 The Erk MAP kinase pathway is activated at muscle spindles and is required for induction of the muscle spindle-specific gene Egr3 by neuregulin1. Journal of neuroscience research 11 24272970
2023 Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3. The Journal of neuroscience : the official journal of the Society for Neuroscience 10 36849419
2022 Salivary microbial dysbiosis may predict lung adenocarcinoma: A pilot study. Indian journal of pathology & microbiology 10 35074976
2022 Specific lncRNA signatures discriminate childhood acute leukaemias: a pilot study. Cancer cell international 10 36451206
2014 Pilot-scale compound screening against RNA editing identifies trypanocidal agents. Journal of biomolecular screening 10 25170016
2023 EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer. Journal of cancer research and clinical oncology 9 37999751
2022 Pilot Study: PARP1 Imaging in Advanced Prostate Cancer. Molecular imaging and biology 9 35701722

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