Affinage

EGR1

Early growth response protein 1 · UniProt P18146

Round 2 corrected
Length
543 aa
Mass
57.5 kDa
Annotated
2026-04-28
130 papers in source corpus 54 papers cited in narrative 54 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EGR1 is a zinc-finger immediate-early transcription factor that integrates diverse extracellular signals—growth factors, stress, mechanical load, and metabolic cues—into context-dependent transcriptional programs governing reproduction, angiogenesis, synaptic plasticity, senescence, autophagy, and fibrosis. It binds the GC-rich consensus CGCCCCCGC through three zinc fingers in a zinc-dependent manner and acts as both a transcriptional activator (recruiting p300/CBP to targets such as LHβ, PTEN, SOX9, SNAI2, LC3B, Per1, and DUSP4) and a repressor (silencing calsequestrin-2, 4E-BP1, and PFKL, in part through NAB1/NAB2 corepressors or EZH2/HDAC complexes) (PMID:3127059, PMID:7624335, PMID:8703054, PMID:18836406, PMID:36932397, PMID:38287371, PMID:34906623). EGR1 is induced primarily via the MEK/ERK–ELK1/SRF axis and is post-translationally regulated by Akt-dependent phosphorylation/ARF-mediated sumoylation that controls PTEN transactivation, and by DNA-PKcs phosphorylation at S301 that prevents proteasomal degradation (PMID:19057511, PMID:34562454). During postnatal brain development EGR1 recruits TET1 to catalyze DNA demethylation at thousands of loci, epigenetically programming neuronal gene expression, while in hematopoietic cells EGR1 haploinsufficiency cooperates with secondary mutations to promote myeloproliferative disease, consistent with a tumor-suppressor role at chromosome 5q (PMID:31467272, PMID:17420284).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1988 High

    Identification of EGR1 as an immediate-early zinc-finger transcription factor that binds CGCCCCCGC established the gene's fundamental molecular identity and DNA-binding mechanism.

    Evidence cDNA cloning, zinc-dependent in vitro DNA binding, nuclear localization by immunocytochemistry in stimulated cells

    PMID:2109185 PMID:3127059

    Open questions at the time
    • Three-dimensional structure of EGR1 zinc-finger/DNA complex not yet resolved at that time
    • Post-translational modifications beyond phosphorylation uncharacterized
  2. 1995 High

    Discovery of the NAB1/NAB2 corepressor system revealed that EGR1 transcriptional output is actively tuned by dedicated repressors binding the R1 domain, explaining how the same factor can activate or dampen gene expression.

    Evidence Yeast two-hybrid identification of NAB1, transcriptional reporter assays for NAB1 and NAB2, domain mapping of NCD2 repression domain

    PMID:7624335 PMID:8668170 PMID:9418898

    Open questions at the time
    • Structural basis of NAB–R1 interaction unknown
    • Genome-wide extent of NAB-dependent repression not mapped
  3. 1996 High

    Egr1-knockout mouse phenotypes—female infertility from LHβ deficiency and reduced GH/body size—demonstrated that EGR1 is essential in vivo for pituitary-gonadal axis function and placed EGR1 as a direct transcriptional activator of LHβ through cooperation with SF-1 and Ptx1.

    Evidence Two independent Egr1-null mouse lines, LHβ promoter mutagenesis, co-IP/GST pulldown of EGR1–SF-1–Ptx1 interactions

    PMID:10082522 PMID:8703054 PMID:9440815

    Open questions at the time
    • Mechanism of species-specific regulation of LHβ by SMAD3/EGR1 not fully resolved
    • EGR1 targets beyond LHβ in gonadotropes not catalogued
  4. 2001 High

    Evidence that EGR1 is required for prostate cancer progression from PIN to invasive carcinoma—but dispensable for tumor initiation—established EGR1 as a context-dependent oncogene that regulates the invasive transition, partly through direct control of cyclin D2, p19INK4d, and Fas.

    Evidence Egr1-null mice crossed to two transgenic prostate cancer models; ChIP and microarray identifying direct targets in prostate cancer cells

    PMID:11135623 PMID:12556466

    Open questions at the time
    • Whether EGR1 pro-tumorigenic role generalizes beyond prostate cancer models unclear at this stage
    • Mechanism of EGR1-dependent invasive switch not fully delineated
  5. 2003 High

    Multiple lines of evidence placed EGR1 at the convergence of MAPK/ERK, PKC, PI3K, and AMPK signaling, establishing it as a signal-integration node that translates kinase cascades into transcriptional programs for angiogenesis (FGF-2), autophagy (LC3B, Atg4B), and metabolic control (DUSP4-mediated gluconeogenesis inhibition).

    Evidence DNAzyme knockdown and Egr1-KO Matrigel angiogenesis assays; ChIP on LC3B promoter with in vivo Egr1-KO emphysema protection; ChIP on DUSP4 promoter with siRNA epistasis in hepatocytes; EP4-PI3K-ERK pathway dissection

    PMID:12566441 PMID:12872165 PMID:16849326 PMID:18836406

    Open questions at the time
    • How EGR1 selects among different target gene programs in different cell types remains unclear
    • Relative contribution of each upstream pathway in physiological contexts not quantified
  6. 2005 High

    In vivo studies in brain established that EGR1 mediates glucocorticoid-MAPK-driven contextual fear conditioning and is required for synaptic potentiation in the anterior cingulate cortex during persistent (but not acute) inflammatory pain, defining EGR1 as a neuronal plasticity effector.

    Evidence Egr1-KO behavioral and electrophysiological phenotypes; brain-specific GR-KO with hippocampal MAPK inhibitor infusions

    PMID:15629414 PMID:15834420

    Open questions at the time
    • Precise downstream transcriptional targets mediating ACC plasticity not identified at that point
    • Whether EGR1's role in pain is cell-type specific within ACC unknown
  7. 2006 High

    Identification of EGR1 as a MAPK-dependent HGF/Snail pathway activator linked EGR1 to epithelial-mesenchymal transition; a Snail-EGR1 negative feedback loop was defined, and EGR1's role in EMT was later reinforced by its activation of SNAI2 via p300/CBP recruitment.

    Evidence shRNA knockdown, ChIP/EMSA for Snail and EGR1 reciprocal promoter binding; ChIP-qPCR and co-IP of EGR1–p300/CBP at SNAI2 promoter with in vivo metastasis validation

    PMID:16858414 PMID:36932397

    Open questions at the time
    • Whether EGR1 drives EMT through Snail/SNAI2 in non-cancer physiological contexts unknown
    • Relative contribution of NAB-mediated repression versus p300/CBP activation at EMT gene promoters not resolved
  8. 2008 High

    An Akt–EGR1–ARF–PTEN feedback axis was defined: Akt phosphorylates EGR1 at S350/T309, promoting ARF/Ubc9-mediated sumoylation at K272, which is required for PTEN transactivation; separately, DNA-PKcs phosphorylation at S301 was shown to stabilize EGR1 protein by blocking proteasomal degradation.

    Evidence Site-directed mutagenesis of phospho- and SUMO-sites, ARF-KO mice, CRISPR-Cas9 S301A knockin in T cells, phosphoproteomics

    PMID:19057511 PMID:34562454

    Open questions at the time
    • Whether additional kinases phosphorylate EGR1 at other sites is not comprehensively mapped
    • Interplay between sumoylation and S301 phosphorylation not tested
  9. 2007 High

    Egr1 haploinsufficiency cooperated with secondary mutations to cause myeloproliferative disease in mice without requiring biallelic loss, establishing a haploinsufficient tumor-suppressor role consistent with EGR1's location in the commonly deleted 5q region in myeloid malignancies.

    Evidence ENU mutagenesis in Egr1+/− mice with disease characterization by flow cytometry and histopathology

    PMID:17420284

    Open questions at the time
    • Specific EGR1 target genes mediating myeloid tumor suppression not identified
    • Whether haploinsufficiency mechanism applies to human del(5q) MDS not directly tested
  10. 2015 High

    EGR1 was integrated into the circadian clock: CLOCK/BMAL1 activate EGR1 via an E-box, and EGR1 in turn directly binds the Per1 promoter and modulates amplitude of multiple core clock genes, placing EGR1 as a clock output effector.

    Evidence ChIP on Per1 promoter, E-box reporter assays, Egr1-KO mice with circadian light/feeding experiments

    PMID:26471974

    Open questions at the time
    • Whether EGR1 functions as a core clock component or peripheral modulator not settled
    • Clock-dependent EGR1 targets beyond Per1 not genome-wide mapped
  11. 2019 High

    Genome-wide studies revealed that EGR1 recruits TET1 to catalyze DNA demethylation at thousands of loci during postnatal brain maturation; Egr1-KO and Tet1-KO frontal cortices share highly overlapping methylation and expression changes, establishing EGR1 as an epigenetic programmer of the neuronal methylome.

    Evidence EGR1 ChIP-seq, whole-genome bisulfite sequencing, RNA-seq in Egr1 and Tet1 KO frontal cortices, co-IP of EGR1–TET1

    PMID:31467272

    Open questions at the time
    • Whether EGR1-TET1 interaction is direct or requires bridging factors not resolved at structural level
    • Whether EGR1 recruits TET1 outside the brain not established
  12. 2024 High

    Integration of proteomics and scRNA-seq in cardiac injury models showed EGR1 orchestrates regenerative senescence: promoting neonatal cardiac angiogenesis and cardiomyocyte proliferation, and mediating agrin-induced senescence in adult hearts via an integrin–FAK–ERK–Akt1 axis in cardiac fibroblasts.

    Evidence Proteomics and scRNA-seq in neonatal/adult heart injury; Egr1-KO/overexpression with agrin treatment; integrin-FAK-ERK-Akt1 pathway inhibition

    PMID:39196027

    Open questions at the time
    • Whether EGR1-driven regenerative senescence is conserved in human hearts unknown
    • Direct transcriptional targets mediating the senescence-to-regeneration switch not catalogued

Open questions

Synthesis pass · forward-looking unresolved questions
  • A systematic understanding of how EGR1 selects between its activator and repressor functions at different loci—integrating cofactor recruitment (NAB1/2 vs. p300/CBP), post-translational modification state, and chromatin context—remains incomplete.
  • No genome-wide map of EGR1 cofactor occupancy distinguishing activator vs. repressor modes
  • Structural basis of EGR1–NAB vs. EGR1–p300 selectivity unresolved
  • Comprehensive catalog of cell-type-specific EGR1 target gene programs lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 14 GO:0003677 DNA binding 6
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-74160 Gene expression (Transcription) 12 R-HSA-162582 Signal Transduction 6 R-HSA-1643685 Disease 4 R-HSA-1266738 Developmental Biology 2 R-HSA-4839726 Chromatin organization 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-9612973 Autophagy 1 R-HSA-9909396 Circadian clock 1
Partners
EP300EZH2MEF2ANAB1NAB2SF-1SMAD3TET1
Complex memberships
EGR1/EZH2/HDAC9 silencing complexEGR1/NAB1 repressor complexEGR1/NAB2 repressor complex

Evidence

Reading pass · 54 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1988 EGR1 (Egr-1) is an immediate-early response gene encoding a nuclear protein with three zinc fingers that binds the consensus sequence CGCCCCCGC in a zinc-dependent manner and functions as a transcriptional regulator. cDNA cloning, sequence analysis, cell fractionation, immunocytochemistry, in vitro DNA binding assay Cell High 3127059
1990 The EGR1 protein is an ~80 kDa short-lived, phosphorylated nuclear protein that binds with high affinity to the sequence CGCCCCCGC in a zinc-dependent manner; identified by anti-EGR1 antiserum in serum-stimulated fibroblasts and NGF-treated PC12 cells. Antisera generation, cell fractionation, immunocytochemistry, in vitro DNA binding assay Molecular and cellular biology High 2109185
1995 NAB1 is a corepressor that interacts with the R1 inhibitory domain of NGFI-A/EGR1 and represses EGR1-mediated transcription; identified by yeast two-hybrid screening and shown not to affect EGR3 or NGFI-G, demonstrating specificity. Yeast two-hybrid, transcriptional reporter assays Proceedings of the National Academy of Sciences of the United States of America High 7624335
1996 NAB2, a second corepressor closely related to NAB1, interacts with the R1 domain of NGFI-A/EGR1 and Krox20 and represses their transcriptional activity; NAB2 expression is itself induced by the same stimuli (serum, NGF) that induce NGFI-A. Protein interaction assays, transcriptional reporter assays, expression analysis Molecular and cellular biology High 8668170
1996 EGR1 (NGFI-A) is required for luteinizing hormone beta (LH-β) transcription in pituitary gonadotropes; NGFI-A-deficient female mice are infertile due to LH-β deficiency, and a canonical NGFI-A binding site in the LH-β promoter is required for synergistic activation by NGFI-A and SF-1. Knockout mice (ES cell-derived), ovariectomy experiments, promoter-reporter assays, in situ hybridization Science High 8703054
1998 NAB1 repression of EGR1-mediated transcription is active (not passive blockade of DNA binding or nuclear localization); the repression function maps to the NCD2 domain in the C-terminal half of NAB1 and works on heterologous activation domains when NAB1 is tethered directly to DNA. Deletion and replacement mutagenesis, tethered-repressor assays, nuclear localization assays Molecular and cellular biology High 9418898
1998 EGR1 (Krox-24) deficiency in mice causes reduced body size and sterility in both sexes due to pituitary defects: somatotropes are reduced in number and GH content is decreased, while gonadotropes fail specifically to synthesize LH-β; additionally, ovarian LH receptor expression is prevented, implicating EGR1 at two levels of the pituitary-gonadal axis. Knockout mouse generation, histological analysis, RIA, immunohistochemistry, in situ hybridization Molecular endocrinology High 9440815
1999 EGR1 is a downstream effector of GnRH signaling via PKC activation; EGR1 directly interacts with both Ptx1 and SF-1 transcription factors, and these interactions synergistically enhance LH-β promoter transcription. Co-immunoprecipitation, GST pulldown, promoter-reporter assays, PKC inhibitor experiments Molecular and cellular biology High 10082522
1999 EGR1 regulates transcription of multiple vascular biology genes and is induced by hemodynamic forces and growth factors in vascular smooth muscle and endothelial cells, placing EGR1 as a convergence point for vascular stress signaling. Promoter-reporter assays, EMSA, in vivo vascular injury models (review synthesizing primary experimental data) The American journal of pathology Medium 10079243
1995 EGR1 protects cells against UV-induced damage; NIH3T3 cells constitutively expressing antisense Egr-1 (unable to produce Egr-1 response) grow significantly slower after UV irradiation; the Egr-1 response to UV is dependent on tyrosine kinase, protein kinase C activities, and c-Ha-Ras, and is mediated by oxidative stress rather than direct DNA damage. Antisense oligonucleotides, kinase inhibitors, cell growth assays Oncogene Medium 7845671
2001 EGR1 is required for progression of prostate cancer from PIN to invasive carcinoma; Egr1-deficient mice in two transgenic prostate cancer models show significantly delayed progression to invasive carcinoma without affecting tumor initiation or growth rate. Egr1 knockout crossed with CR2-T-Ag and TRAMP transgenic prostate cancer models; MRI, histopathology, survival analysis Nature medicine High 11135623
2003 EGR1 directly regulates transcription of cyclin D2, p19INK4d, and Fas/CD95 in prostate cancer cells; EGR1-mediated inhibition of Fas expression contributes to resistance to FasL-induced apoptosis. Affymetrix microarray, real-time PCR, immunoblot, chromatin immunoprecipitation (ChIP), antisense oligonucleotides The Journal of biological chemistry High 12556466
2003 EGR1 supports FGF-dependent angiogenesis; EGR1 DNAzymes inhibit microvascular endothelial cell replication, migration, and tube formation, block Matrigel angiogenesis in mice, and suppress endothelial FGF-2 (but not VEGF) expression; Egr1-deficient mice also show impaired angiogenesis. DNAzyme knockdown, Matrigel plug assays, Egr1 knockout mice, endothelial cell functional assays (proliferation, migration, tube formation) Nature medicine High 12872165
2003 EGR1 mediates inhibition of 4E-BP1 expression downstream of ERK and p38 MAPK activation; a dominant-negative EGR mutant (ZnEgr) blocks PMA-induced and GM-CSF-induced repression of the 4e-bp1 promoter, showing EGR1 directly represses 4E-BP1 transcription. Dominant-negative EGR mutant, promoter-reporter assays, MAPK inhibitors, Western blotting The Journal of biological chemistry Medium 12618431
2003 HGF induces cell scattering through a MAPK/EGR1/Snail pathway; EGR1 is required for HGF-induced upregulation of Snail, which in turn represses E-cadherin and claudin-3; Snail also binds the EGR1 promoter establishing a negative feedback loop. shRNA knockdown, promoter-reporter assays, ChIP, EMSA, invasion assays The EMBO journal High 16858414
2005 EGR1 directly binds the heparanase gene promoter in vivo and activates heparanase transcription in multiple tumor cell lines (prostate, breast, colon adenocarcinomas) through two functional EGR1 sites; EGR1 can also repress heparanase promoter activity in melanoma cells, demonstrating cell-type-dependent dual regulation. ChIP, EMSA, site-directed mutagenesis, transactivation reporter assays The Journal of biological chemistry High 16093249
2005 EGR1 is required for behavioral responses to persistent inflammatory pain but not acute pain; Egr1 knockout mice show significantly reduced nociceptive responses to peripheral inflammation, and inflammation triggers EGR1 upregulation in the anterior cingulate cortex; synaptic potentiation by theta-burst stimulation in ACC is reduced in Egr1 knockout mice. Egr1 knockout mice, behavioral pain assays, LTP electrophysiology in ACC slices The journal of pain High 15629414
2005 The MAPK pathway and EGR1 mediate stress-related behavioral effects of glucocorticoids; glucocorticoid receptor activation increases MAPK pathway protein activity and EGR1 mRNA/protein in hippocampus; MAPK inhibition within hippocampus abolishes glucocorticoid-induced enhancement of contextual fear conditioning. Brain-specific GR knockout mice, cell lines with inducible GR, MAPK activity assays, hippocampal drug infusions, behavioral fear conditioning Nature neuroscience High 15834420
2003 EGR1 is induced via PI3K/ERK signaling downstream of the EP4 (but not EP2) prostaglandin receptor; PGE2 stimulation of EP4 leads to phosphorylation of ERKs through PI3K and subsequent functional EGR1 protein expression. Selective EP receptor agonists, PI3K inhibitors, ERK phosphorylation assays, Western blotting for EGR1 The Journal of biological chemistry Medium 12566441
2006 EGR1 transactivates the TP73 P1 promoter (but not P2) through five distinct EGR1-binding sites, upregulating TAp73; induction of TAp73 by genotoxic stress requires EGR1 in vivo; EGR1, p53, and p73 form an inter-regulating network with non-consensus p53-binding sites in each other's promoters creating feedback loops for sustained apoptotic signaling. Promoter-reporter assays, EMSA, ChIP, in vivo stress models (EGR1-deficient mice) Cell death and differentiation High 16990849
2006 AMPK activation induces EGR1 expression, which directly binds the DUSP4 promoter to activate DUSP4 transcription; EGR1 and DUSP4 together mediate AMPK-dependent inhibition of hepatic gluconeogenesis (repressing PEPCK and G6Pase promoter activity and expression). Transcriptional profiling, reporter assays, ChIP, siRNA knockdown, glucose production assay The Journal of biological chemistry High 16849326
2008 EGR1 is phosphorylated by Akt at S350 and T309; this phosphorylation promotes interaction of EGR1 with ARF, leading to ARF/Ubc9/SUMO-mediated sumoylation of EGR1 at K272 in its repressor domain; sumoylated EGR1 is required for PTEN transactivation in vivo—defining an Akt-EGR1-ARF-PTEN axis. Site-directed mutagenesis, co-IP, sumoylation assays, ARF knockout mice, in vivo PTEN expression analysis The EMBO journal High 19057511
2008 EGR1 directly binds the calsequestrin 2 (CSQ2) promoter and acts as a transcriptional repressor; overexpression of Egr-1 reduces CSQ expression and abolishes calcium release from CSQ-dependent ryanodine-sensitive stores, while leaving calreticulin-dependent IP3-sensitive stores unaffected; EGR1 forms a complex with NFAT3 at the CSQ2 promoter. Adenoviral overexpression, immunoblot, in vivo and in vitro ChIP, calcium imaging (fura-2), co-IP, site-directed mutagenesis (I293F) Cardiovascular research High 19103607
2008 Upon induction, EGR1 occupies its own gene promoter without competing with Sp1; phosphorylation of ELK1 and CREB via MEK1/2 and p38 kinases is required for EGR1 gene induction; NAB1 and NAB2 bind the EGR1 promoter to terminate transcription; histone acetylation changes accompany activation. ChIP, pharmacological kinase inhibition, quantitative promoter occupancy mapping Cellular and molecular life sciences Medium 20582451
2008 Egr-1 directly binds the LC3B autophagy gene promoter (with E2F-4) and activates LC3B expression in response to cigarette smoke extract (CSE); Egr-1 also activates Atg4B; Egr1-deficient mice resist cigarette smoke-induced autophagy, apoptosis, and emphysema. ChIP, siRNA knockdown, Egr1 knockout mice, HDAC activity assays, electron microscopy PloS one High 18836406
2009 The transcription factors Egr1 and Egr2 have opposing roles in adipocyte differentiation: Egr1 inhibits adipogenesis (overexpression blocks, knockdown potentiates differentiation), while Egr2 promotes it; pro-adipogenic effects of IBMX involve suppression of Egr1's inhibitory influence. Ectopic expression, siRNA knockdown, 3T3-L1 adipocyte differentiation assays, promoter-reporter assays Cell death and differentiation Medium 19229250
2010 miR-183 directly targets and downregulates EGR1 mRNA in multiple tumor types (synovial sarcoma, rhabdomyosarcoma, colon cancer); miR-183 knockdown derepresses EGR1, activating a miR-183-EGR1-PTEN tumor suppressor network; EGR1 mediates the effect of miR-183 on cell migration. miRNA overexpression/knockdown, luciferase reporter assays (3′UTR), integrative genomic analysis, migration assays Cancer research Medium 21118966
2010 SMAD3 physically interacts with EGR1 via the SMAD3 MH2 domain and the EGR1 DNA-binding domain; SMAD3 modulates EGR1 occupancy at the LHB promoter in a species-specific manner: SMAD3 inhibits EGR1-driven human LHB transcription and reduces EGR1 promoter recruitment, while potentiating EGR1-driven murine Lhb transcription when SMAD-binding elements (SBEs) are present. Co-IP, GST pulldown, ChIP, domain-mapping mutagenesis, promoter-reporter assays with SBE swap mutants Cellular signalling High 20149866
2013 Genome-wide EGR1 ChIP-seq in APP23 Alzheimer's disease model mouse brains identifies EGR1 binding near genes for synaptic plasticity (Arc, Grin1, Syn2, Vamp2, Stx6) and AD-related genes (Picalm, Psen2, App); EGR1 binding correlates with activating chromatin marks; conditions that upregulate Egr1 (spatial memory task) also increase expression of these targets. ChIP-seq, quantitative ChIP-PCR, behavioral testing, protein expression analysis in APP23 vs. wild-type mice Neurobiology of disease High 24269917
2015 EGR1 directly binds the proximal Per1 promoter to activate its transcription; EGR1 is itself transcriptionally activated by the CLOCK/BMAL1 heterodimer through a conserved E-box element; EGR1 regulates the amplitude of multiple core clock genes (Bmal1, Per1, Per2, Rev-erbα, Rev-erbβ) in hepatocytes. ChIP, E-box reporter assays, Egr1 knockout mice with light/feeding phase experiments, qRT-PCR Scientific reports High 26471974
2015 EGR1 functions as a potent repressor of MEF2 transcriptional activity; EGR1 physically interacts with MEF2A, and costamere gene expression in cardiomyocytes is dependent on EGR1 transcriptional activity. Co-IP, transcription reporter assays, siRNA knockdown of EGR1 in cardiomyocytes, bioinformatic promoter analysis PloS one Medium 26011708
2015 EGR1 translation is regulated by the mTORC1/4E-BP axis; 4E-BP1/2-null cells translate EGR1 mRNA more efficiently despite lower mRNA levels; mTORC1 inhibitors (rapamycin, PP242) suppress EGR1 protein without increasing mRNA; EGR1-dependent repression of adipose triglyceride lipase (ATGL) promotes fat storage. 35S-methionine labeling (translation assay), 4E-BP1/2 and TSC2 genetic knockout MEFs, mTORC1 inhibitors, siRNA, adipocyte lipid accumulation assays The Journal of biological chemistry High 25814662
2016 EGR1 expression is mechanosensitive in tendon cells; EGR1 directly responds to mechanical signals and overexpression of EGR1 prevents downregulation of tendon-specific genes (e.g., Scx, Col1) when tension is released from 3D-engineered tendons or during tendon healing under reduced mechanical load. 3D tendon organoid culture with tension release, in vivo tendon healing with reduced load, ultrasound/microbubble-mediated EGR1 overexpression PloS one Medium 27820865
2016 Egr-1 deficiency protects mice from renal inflammation and fibrosis; Egr1-/- mice on an adenine-rich diet show attenuated NF-κB activity, reduced cytokine/chemokine expression, and reduced TGFβ signaling and fibrotic area; in vitro, Egr-1 deficiency blunts primary tubular epithelial cell responses to TNFα and TGFβ. Egr1 knockout mice, adenine-induced TIN model, primary tubular epithelial cell cultures with cytokine treatment, NF-κB activity assays Journal of molecular medicine High 26960759
2018 ER stress activates EGR1 transcription via a SRC-RAS-RAF-MEK-ERK cascade leading to ELK1 phosphorylation; ELK1 and SRF are constitutively bound to the EGR1 promoter, but phospho-ELK1 abundance increases upon ER stress; ELK1 knockdown completely blocks ER stress-induced EGR1 mRNA increase. siRNA knockdown of ELK1 and SRF, ERK pathway inhibitors, ChIP for promoter occupancy of phospho-ELK1 and phospho-SRF, kinase cascade inhibitors Biochimica et biophysica acta. Molecular cell research Medium 30290239
2019 EGR1 recruits TET1 to specific genomic loci to mediate DNA demethylation during postnatal brain development; EGR1 ChIP-seq shows thousands of binding sites that become hypomethylated in mature neurons; frontal cortices from Egr1 or Tet1 knockout mice share highly similar gene expression and methylation profiles. EGR1 ChIP-seq, whole-genome bisulfite sequencing, Egr1 and Tet1 knockout mice, RNA-seq, co-IP Nature communications High 31467272
2019 EGR1 regulates angiogenic and osteoclastogenic factors (PDGFA, TGFB1, SPP1, IL6, IL8, TGFA) in prostate cancer metastases; FN14 (TNFRSF12A) ligation drives NF-κB-independent, MEK-dependent EGR1 expression; EGR1 depletion reduces metastasis number/size, blood vessel density in metastases, and osteolytic bone lesion area. EGR1 knockdown in metastasis model (DU145/RasB1), intracardiac injection metastasis assays, histology for vascularization and osteoclasts, MEK inhibitor experiments Oncogene High 31312026
2019 EGR1 binds the CMV viral genome upstream of the UL138 latency gene and is sufficient to promote UL138 expression; disruption of EGR1 binding upstream of UL138 prevents establishment of CMV latency in CD34+ hematopoietic progenitor cells; EGR1 is induced via MEK/ERK downstream of EGFR signaling and is important for hematopoietic stemness. EGR1 ChIP on viral genome, site-directed mutagenesis of EGR1 binding sites, CD34+ HPC infection/latency assays, MEK/ERK/PI3K inhibition PLoS pathogens High 31725811
2019 MIR2052HG lncRNA interacts with EGR1 protein and facilitates EGR1 recruitment to the LMTK3 promoter; EGR1 is required for LMTK3 transcription, which sustains ERα levels in breast cancer cells. RNA-binding protein immunoprecipitation (RIP), ChIP, RNA-DNA dual FISH, luciferase reporter assays Breast cancer research Medium 30944027
2019 Fasting and glucose restriction activate EGR1 via regulation of PKA and AMPK pathways; EGR1 functions as the mammalian ortholog of yeast Msn2/4 stress-resistance transcription factors; EGR1 activates cardioprotective peptides ANP and BNP, contributing to protection against doxorubicin toxicity. Fasting/glucose restriction experiments in mice, PKA and AMPK pharmacological manipulation, cardiac gene expression analysis, doxorubicin toxicity assays PLoS biology Medium 28358805
2021 DNA-PKcs phosphorylates EGR1 at serine 301; this phosphorylation stabilizes EGR1 by preventing proteasomal degradation; S301A mutation (via CRISPR-Cas9) reduces EGR1 protein levels and decreases EGR1-dependent IL-2 transcription in activated T cells. Quantitative phosphoproteomic screen in T cells, DNA-PKcs inhibitor (NU7441) and shRNA knockdown, CRISPR-Cas9 S301A knockin, proteasome inhibitor rescue, IL-2 reporter assay The Journal of biological chemistry High 34562454
2019 RAF-induced oncogenic signaling activates EGR1 transcription via the MEK-ERK MAPK pathway; EGR1 in turn regulates p15 (CDKN2B) and p21 (CDKN1A) expression, which are redundantly required for B-RAF-V600E-induced proliferative arrest (senescence) in human fibroblasts; glucocorticoids suppress EGR1 and thereby delay senescence entry. B-RAF-V600E expression in fibroblasts, transcriptome analysis, siRNA knockdown of EGR1, glucocorticoid treatment, MEK inhibitors Journal of cell science Medium 31371485
2021 TET2 is recruited to the MIF promoter and interacts with EGR1 and histone deacetylases; disruption of these interactions due to TET2 downregulation favors EGR1-driven transcription of MIF and its secretion from monocytes; EGR1 drives MIF overproduction in the absence of TET2. ChIP for TET2 at MIF promoter, co-IP of TET2/EGR1/HDAC complex, TET2 knockdown and knockout models, MIF secretion ELISA Communications biology Medium 35115654
2022 EGR1 directly binds the SOX9 gene promoter in renal tubular cells to activate SOX9 expression; EGR1 induction in early AKI promotes SOX9+ progenitor cell proliferation via the Wnt/β-catenin pathway; Egr1 knockout mice show aggravated AKI severity. ChIP assay, dual-luciferase reporter assay, RNA-seq, Egr1 knockout mice in IRI and nephrotoxic AKI models, immunofluorescence Theranostics High 35910788
2023 Nuclear PD-L1 facilitates p-STAT3 binding to the EGR1 promoter, activating EGR1-mediated angiogenesis; HDAC2 inhibition restores PD-L1 acetylation and blocks its nuclear translocation, thereby attenuating EGR1-driven tumor angiogenesis. ChIP for p-STAT3 at EGR1 promoter, nPD-L1-deficient cell lines, in vitro and in vivo angiogenesis assays, HDAC2 inhibitor treatment Cell discovery Medium 36977660
2023 EGR1 directly binds the SNAI2 promoter and recruits p300/CBP as a coactivator to drive SNAI2 transcription, thereby promoting EMT and invasion in pancreatic cancer; co-IP confirms EGR1-p300/CBP interaction. ChIP-qPCR for EGR1 at SNAI2 promoter, co-IP of EGR1 and p300/CBP, dual-luciferase reporter assay, transwell migration/invasion assays, in vivo liver metastasis model Journal of translational medicine Medium 36932397
2024 EGR1 directly binds the PFKL promoter and represses PFKL expression, thereby suppressing aerobic glycolysis (Warburg effect) in hepatocellular carcinoma; EGR1 overexpression inhibits HCC xenograft growth and sensitizes cells to sorafenib. ChIP for EGR1 at PFKL promoter, dual-luciferase reporter assay, EGR1 overexpression/KO in HCC cell lines and xenografts, human hepatoma organoids, glycolysis assays Journal of experimental & clinical cancer research Medium 38287371
2024 Egr1 regulates regenerative senescence in the heart; in neonatal hearts, Egr1 promotes angiogenesis and cardiomyocyte proliferation during regeneration; in adult hearts, agrin-induced senescence and repair require Egr1, which is activated by the integrin-FAK-ERK-Akt1 signaling axis in cardiac fibroblasts. Proteomics, single-cell RNA sequencing, Egr1 knockout/overexpression in neonatal and adult cardiac injury models, agrin treatment, integrin-FAK-ERK-Akt1 pathway inhibition Nature cardiovascular research High 39196027
2007 Egr1 haploinsufficiency cooperates with ENU-induced mutations to cause myeloproliferative disease and T-cell lymphomas in mice at increased rates; biallelic Egr1 mutations were not observed in MPDs from Egr1+/- mice, supporting a haploinsufficiency tumor suppressor role for EGR1 in myeloid malignancies associated with del(5q). Egr1 heterozygous and null mice treated with ENU, disease characterization by blood counts, flow cytometry, histopathology Blood High 17420284
2008 APE1/Ref-1 acetylation is required for EGR1-dependent PTEN gene activation; acetylated APE1 enhances binding to transcriptional complexes at the PTEN promoter; APE1-dependent PTEN expression requires EGR1, as shown by ectopic EGR1 expression in APE1-downregulated cells. APE1 siRNA knockdown, ectopic EGR1 expression, APE1 acetylation assays, PTEN expression analysis, HDAC inhibitor experiments Free radical research Medium 18324520
2019 EGR1 directly transactivates the EGR1 splicing isoform; a newly identified EGR1 splicing isoform lacks part of the N-terminal activation domain, can enter the nucleus, but is unable to fully activate transcription compared to canonical EGR1. Identification of splice isoform by RT-PCR/sequencing, nuclear localization by immunofluorescence, transcriptional activation reporter assays International journal of molecular sciences Low 30925677
2018 EGR1/EZH2/HDAC9 form a repressor complex that maintains high H3K27-Me3 at the EBF3 promoter to silence EBF3 in nasopharyngeal carcinoma; EGR1 is a component of this epigenetic silencing complex. Co-IP, ChIP for H3K27-Me3 and complex components at EBF3 promoter, rescue experiments Cancer letters Medium 34906623
2021 EGR1 directly binds the GADD45A promoter to activate its transcription in thyroid carcinoma cells treated with non-thermal plasma-activated medium; EGR1/GADD45α signaling mediates ROS-induced apoptotic cell death. ChIP for EGR1 at GADD45A promoter, EGR1 overexpression/siRNA, ROS scavengers, xenograft tumor models Cancers Medium 33477921
2021 EGR1 upregulates expression of MYC and E2F pathway genes through the CBP/p300/H3K27ac/BRD4 axis in DLBCL, while repressing type I IFN pathway genes through interaction with the corepressor NAB2; EGR1 inhibition synergizes with BRD4 inhibitor JQ1 or lenalidomide in ABC DLBCL. EGR1 knockdown (genetic and pharmacologic), ChIP for H3K27ac and BRD4, co-IP with NAB2, xenograft models, combination drug assays Molecular cancer research Medium 33980611

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Biological insights from 108 schizophrenia-associated genetic loci. Nature 5878 25056061
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1988 A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 1237 3127059
2009 A census of human transcription factors: function, expression and evolution. Nature reviews. Genetics 1191 19274049
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2017 Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science (New York, N.Y.) 934 28473536
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2002 Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthritis and cartilage 432 11795984
1996 Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science (New York, N.Y.) 425 8703054
2018 Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science (New York, N.Y.) 400 30385546
2008 Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PloS one 389 18830406
2018 DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell 379 29656893
1990 Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Molecular and cellular biology 346 2109185
1996 NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Molecular and cellular biology 328 8668170
2003 Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nature medicine 322 12872165
2004 A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK? Progress in neurobiology 312 15556287
2011 Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational psychiatry 306 22832523
2006 Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. The EMBO journal 293 16858414
2017 The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders. Frontiers in behavioral neuroscience 280 28321184
2003 Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. The Journal of biological chemistry 261 12566441
2010 MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. Cancer research 249 21118966
1995 Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proceedings of the National Academy of Sciences of the United States of America 240 7624335
1998 Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice. Molecular endocrinology (Baltimore, Md.) 232 9440815
1999 Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription. Molecular and cellular biology 225 10082522
1999 Pathways of Egr-1-mediated gene transcription in vascular biology. The American journal of pathology 224 10079243
2004 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes & development 220 14744935
2021 The Role of the Transcription Factor EGR1 in Cancer. Frontiers in oncology 210 33842351
2005 The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nature neuroscience 195 15834420
2007 Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood 173 17420284
2011 ERG gene rearrangements are common in prostatic small cell carcinomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 167 21336263
2010 A human MAP kinase interactome. Nature methods 165 20936779
2018 EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer. Cancer research 163 30185552
2009 Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proceedings of the National Academy of Sciences of the United States of America 159 19307576
2001 Impaired prostate tumorigenesis in Egr1-deficient mice. Nature medicine 150 11135623
2014 The transcription factor Zif268/Egr1, brain plasticity, and memory. Progress in molecular biology and translational science 149 24484699
2003 Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes. The Journal of biological chemistry 133 12556466
2019 EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis. Oncogene 125 31312026
2019 EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity. Nature communications 116 31467272
2008 PTEN regulation by Akt-EGR1-ARF-PTEN axis. The EMBO journal 115 19057511
2016 A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nature communications 104 27041221
1991 5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8. Oncogene 104 2052361
2009 Is EGR1 a potential target for prostate cancer therapy? Future oncology (London, England) 98 19792968
1998 Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. Molecular and cellular biology 97 9418898
2018 HPSE enhancer RNA promotes cancer progression through driving chromatin looping and regulating hnRNPU/p300/EGR1/HPSE axis. Oncogene 93 29511351
2006 A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell death and differentiation 87 16990849
2015 miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer. Oncotarget 86 26376677
2009 The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation. Cell death and differentiation 82 19229250
2016 Egr-1 deficiency protects from renal inflammation and fibrosis. Journal of molecular medicine (Berlin, Germany) 81 26960759
2020 EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer. Cell proliferation 80 33145887
2023 Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis. Cell discovery 77 36977660
2005 Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells. The Journal of biological chemistry 76 16093249
2006 Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. The Journal of biological chemistry 68 16849326
2013 Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration. Neurobiology of disease 67 24269917
2019 Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency. PLoS pathogens 60 31725811
2016 Age-related changes in Egr1 transcription and DNA methylation within the hippocampus. Hippocampus 60 26972614
1995 A biological role for Egr-1 in cell survival following ultra-violet irradiation. Oncogene 59 7845671
2022 Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9+ renal tubular cells. Theranostics 58 35910788
2017 Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS biology 54 28358805
2017 High glucose alters tendon homeostasis through downregulation of the AMPK/Egr1 pathway. Scientific reports 52 28266660
2016 EGR1 Regulates Transcription Downstream of Mechanical Signals during Tendon Formation and Healing. PloS one 52 27820865
2003 ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1. The Journal of biological chemistry 52 12618431
2005 Selective contribution of Egr1 (zif/268) to persistent inflammatory pain. The journal of pain 51 15629414
2017 Inhibition of EGR1 inhibits glioma proliferation by targeting CCND1 promoter. Journal of experimental & clinical cancer research : CR 50 29246166
2008 APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free radical research 50 18324520
2019 MiR-150-5p retards the progression of myocardial fibrosis by targeting EGR1. Cell cycle (Georgetown, Tex.) 47 31122130
2002 Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells. Biology of reproduction 44 11870074
2019 The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1. Breast cancer research : BCR 43 30944027
2024 EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL. Journal of experimental & clinical cancer research : CR 41 38287371
2019 Targeted alpha therapy with bismuth-213 and actinium-225: Meeting future demand. Journal of labelled compounds & radiopharmaceuticals 40 31369165
2022 Examining the role of EGR1 during viral infections. Frontiers in microbiology 39 36338037
2012 Consistency test of the cell cycle: roles for p53 and EGR1. Cancer research 39 22315347
2008 Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome biology 39 19032775
2005 Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1. Annals of the New York Academy of Sciences 37 16382041
2019 Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis. Arthritis research & therapy 36 30971291
2023 EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway. Journal of translational medicine 35 36932397
2015 MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1. Oncotarget 35 25906746
2015 EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription. Scientific reports 35 26471974
1997 Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle. The European journal of neuroscience 35 9464931
2021 Cyclotron production of 225Ac from an electroplated 226Ra target. European journal of nuclear medicine and molecular imaging 34 34196752
2022 [225Ac]Ac-SibuDAB for Targeted Alpha Therapy of Prostate Cancer: Preclinical Evaluation and Comparison with [225Ac]Ac-PSMA-617. Cancers 33 36428743
2010 Factor binding and chromatin modification in the promoter of murine Egr1 gene upon induction. Cellular and molecular life sciences : CMLS 32 20582451
2017 EGR1 regulates cellular metabolism and survival in endocrine resistant breast cancer. Oncotarget 31 29228577
2010 The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1. International journal of cancer 31 19816943
2019 Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer. BMC cancer 30 31399076
2009 Amino acid residues 196-225 of LcrV represent a plague protective epitope. Vaccine 30 20005318
2021 Early growth response 1 (EGR1) activation in initial stages of host-pathogen interactions. Molecular biology reports 29 33783681
2018 Induction of early growth response gene 1 (EGR1) by endoplasmic reticulum stress is mediated by the extracellular regulated kinase (ERK) arm of the MAPK pathways. Biochimica et biophysica acta. Molecular cell research 29 30290239
2008 Egr1 involvement in evening gene regulation by melatonin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29 19019852
2018 EGR1 interacts with TBX2 and functions as a tumor suppressor in rhabdomyosarcoma. Oncotarget 28 29719592
2013 The role of egr1 in early zebrafish retinogenesis. PloS one 28 23405257
2000 Investigations into a biomimetic approach toward CP-225,917 and CP-263,114. The Journal of organic chemistry 28 10813939
2024 Egr1 regulates regenerative senescence and cardiac repair. Nature cardiovascular research 27 39196027
2022 EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death. Viruses 27 35746681
2018 REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells. Oncology reports 27 29393474
2008 Egr-1 negatively regulates calsequestrin expression and calcium dynamics in ventricular cells. Cardiovascular research 27 19103607
2015 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL. The Journal of biological chemistry 25 25814662
2017 Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions. Journal of virology 24 28615203
2013 Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats. Pharmacological reports : PR 24 23744421
2002 Expression of the zinc finger Egr1 gene during zebrafish embryonic development. Mechanisms of development 24 12351200
1999 Involvement of the NGFI-A gene in the differentiation of neuroblastoma cells. FEBS letters 24 10561492
2022 Macrophage migration inhibitory factor is overproduced through EGR1 in TET2low resting monocytes. Communications biology 23 35115654
2022 Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway. International journal of biological sciences 22 35982887
2020 Evaluation of Actinium-225 Labeled Minigastrin Analogue [225Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy. Pharmaceutics 22 33198403
2009 Early growth response 1 (EGR1): a gene with as many names as biological functions. Cancer biology & therapy 22 20009530
2019 Glucocorticoids delay RAF-induced senescence promoted by EGR1. Journal of cell science 21 31371485
2011 GROβ and its downstream effector EGR1 regulate cisplatin-induced apoptosis in WHCO1 cells. Oncology reports 21 21271225
2021 Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes. International journal of molecular sciences 20 33919431
2014 Egr-1 is a key regulator of IL-17A-induced psoriasin upregulation in psoriasis. Experimental dermatology 20 25256120
2021 EBF3 reactivation by inhibiting the EGR1/EZH2/HDAC9 complex promotes metastasis via transcriptionally enhancing vimentin in nasopharyngeal carcinoma. Cancer letters 19 34906623
2014 Egr-1 upregulates Siva-1 expression and induces cardiac fibroblast apoptosis. International journal of molecular sciences 19 24451137
2010 SMAD3 and EGR1 physically and functionally interact in promoter-specific fashion. Cellular signalling 19 20149866
2007 Evidence of EGR1 as a differentially expressed gene among proliferative skin diseases. Genomic medicine 19 18923931
2021 DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry 18 34562454
2008 Evaluation of EGR1 as a candidate gene for high myopia. Molecular vision 18 18636116
2022 LncRNA-COX2 inhibits Fibroblast Activation and Epidural Fibrosis by Targeting EGR1. International journal of biological sciences 17 35280679
2021 EGR1/GADD45α Activation by ROS of Non-Thermal Plasma Mediates Cell Death in Thyroid Carcinoma. Cancers 17 33477921
2020 RUNX2 co-operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers. Journal of cellular physiology 17 32324256
2001 EGR-1, a UV-inducible gene in p53(-/-) mouse cells. Experimental cell research 17 11339821
1998 Vasopressin-induction of the immediate early gene, NGFI-A, in cultured hippocampal glial cells. Brain research. Molecular brain research 17 9630527
2020 EZH2 overexpression dampens tumor-suppressive signals via an EGR1 silencer to drive breast tumorigenesis. Oncogene 16 33009487
2019 TBA225, a fusion toxoid vaccine for protection and broad neutralization of staphylococcal superantigens. Scientific reports 16 30824769
2018 Structure and properties of DOTA-chelated radiopharmaceuticals within the 225Ac decay pathway. MedChemComm 16 30109003
2018 Leptin is a direct transcriptional target of EGR1 in human breast cancer cells. Molecular biology reports 16 30417207
2023 DDIT3 aggravates pulpitis by modulating M1 polarization through EGR1 in macrophages. International immunopharmacology 15 37235961
2015 EGR1 Functions as a Potent Repressor of MEF2 Transcriptional Activity. PloS one 15 26011708
2021 EGR1 Addiction in Diffuse Large B-cell Lymphoma. Molecular cancer research : MCR 14 33980611
2019 Identification, Characterization, and Regulatory Mechanisms of a Novel EGR1 Splicing Isoform. International journal of molecular sciences 14 30925677