Affinage

MYL6

Myosin light polypeptide 6 · UniProt P60660

Length
151 aa
Mass
16.9 kDa
Annotated
2026-06-10
56 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge faithfulness: 4/5 claims corpus-supported (80%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MYL6 is the essential (alkali) myosin light chain that integrates into non-muscle myosin II and class V myosin holoenzymes, where it associates with the heavy chains MYH9 and MYH10 and with regulatory light chains MYL12A/B and MYL9, and its stability within the complex depends on regulatory light chain expression (PMID:21126233). Beyond its structural role in the holoenzyme, it can serve as a functional light chain for Myosin 5c, supporting actin-activated ATPase and motility in reconstituted complexes (PMID:38606007). The MYL6 gene generates closely related essential light chain isoforms by alternative splicing, with isoform-specific N-terminal lobes dictating subcellular sorting and a stress-responsive C-terminal switch that alters interaction properties within the myosin complex (PMID:8856505, PMID:2304459, PMID:40418580). Through its myosin-associated, actin-coupled activity MYL6 supports diverse cytoskeleton-dependent cellular processes: in the megakaryocyte/platelet lineage it binds kindlin-3 and is required for integrin αIIbβ3 avidity modulation, proplatelet formation, and hemostasis, with conditional knockout producing macrothrombocytopenia (PMID:38266679); it enables the actin rearrangement underlying neutrophil extracellular trap formation (PMID:36527167); and in lung endothelium it is activated downstream of STIM1-dependent Ca2+ signaling to engage phospho-Tyr242 cGAS, driving cGAS condensation and type I interferon innate immune signaling (PMID:42154837). During spermiogenesis MYL6 requires the BAG5–HSPA8 chaperone axis for proper folding during assembly of the sperm head-tail coupling apparatus, and its misfolding causes acephalic spermatozoa (PMID:38454159).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1990 Medium

    Established the molecular identity of MYL6 as a gene encoding multiple essential light chain isoforms generated by alternative splicing, defining the nonmuscle alkaline myosin light chain.

    Evidence cDNA cloning, isoform-specific probes, and RNA expression analysis across species and cell types

    PMID:2304459

    Open questions at the time
    • Functional difference between MLC1sa and MLC3nm isoforms not resolved
    • No structural data on light chain–heavy chain binding
  2. 1996 Medium

    Resolved why MYL6 distributes diffusely rather than into sarcomeres, attributing isoform-specific sorting to the N-terminal lobe and establishing its nonmuscle character.

    Evidence Epitope-tagging competition assay with confocal microscopy and chimeric cDNA expression in rat cardiomyocytes

    PMID:8856505

    Open questions at the time
    • Sorting determinant mapped to N-lobe but binding partners conferring specificity not identified
    • Studied in cardiomyocyte context only
  3. 2009 Low

    Identified MYL6 as a candidate interaction partner of the RNA-binding protein PCBP1, an early hint of non-cytoskeletal associations.

    Evidence Yeast two-hybrid, yeast pulldown, co-IP, and immunofluorescence

    PMID:19727228

    Open questions at the time
    • No functional consequence established for the MYL6–PCBP1 interaction
    • Single lab, interaction screen only
  4. 2011 Medium

    Defined MYL6 as a stable component of the non-muscle myosin II complex and showed its protein stability depends on regulatory light chain expression.

    Evidence Co-IP/MS proteomic association and siRNA knockdown with Western blot in NIH 3T3 fibroblasts

    PMID:21126233

    Open questions at the time
    • Stoichiometry within the holoenzyme not quantified
    • Whether RLC dependence holds in non-fibroblast cells untested
  5. 2015 Low

    Linked MYL6 to spermiogenesis by identifying its interaction with the HTCA-assembly protein SPATA6, implicating myosin-based transport during sperm head-tail coupling.

    Evidence Proteomic analysis of SPATA6-interacting proteins in mouse spermatids

    PMID:25605924

    Open questions at the time
    • Single proteomic pulldown with no MYL6-specific functional follow-up
    • Direct vs indirect binding not distinguished
  6. 2021 Low

    Reinforced MYL6 as a functional subunit of non-muscle myosin IIA whose activity can be modulated by an interacting lncRNA.

    Evidence RIP/pulldown, ATPase assay after MAFG-AS1 knockdown, and co-IP of NM IIA subunits

    PMID:33813778

    Open questions at the time
    • MYL6 a secondary finding; ATPase readout indirect for MYL6 role
    • Mechanism by which lncRNA tunes complex unclear
  7. 2022 Medium

    Demonstrated MYL6 is required for actin polymerization driving neutrophil extracellular trap formation, connecting it to innate immune effector function.

    Evidence Anti-MYL6 antibody inhibition of actin polymerization and NET formation in neutrophils; clinical correlation in microscopic polyangiitis

    PMID:36527167

    Open questions at the time
    • Antibody-based loss of function; genetic confirmation absent
    • Molecular step between MYL6 and actin assembly not defined
  8. 2022 Medium

    Placed MYL6 downstream of ADCK2 in the control of melanoma cell migration via an epistasis experiment.

    Evidence ADCK2 overexpression and MYL6 knockdown with scratch and transwell migration assays

    PMID:35205819

    Open questions at the time
    • Mechanistic link between ADCK2 and MYL6 not defined
    • Whether the effect operates through myosin contractility untested
  9. 2024 High

    Provided the strongest genetic evidence for MYL6 function: kindlin-3 binding and a requirement for integrin αIIbβ3 avidity, proplatelet formation, and hemostasis.

    Evidence Megakaryocyte-lineage conditional knockout mouse, integrin activation and aggregation assays, co-IP, and in vivo thrombosis models

    PMID:38266679

    Open questions at the time
    • Structural basis of MYL6–kindlin-3 interaction unknown
    • How a myosin light chain regulates integrin avidity mechanistically unresolved
  10. 2024 Medium

    Established that MYL6 requires the BAG5–HSPA8 chaperone axis for folding during sperm head-tail coupling apparatus assembly, with misfolding causing acephalic spermatozoa.

    Evidence BAG5 knockout mouse, in vivo/in vitro folding assays, and co-IP

    PMID:38454159

    Open questions at the time
    • Whether MYL6 misfolding alone causes the phenotype not isolated
    • Folding requirement in other tissues untested
  11. 2024 Medium

    Demonstrated by reconstitution that MYL6 can serve as the essential light chain for Myosin 5c, conferring actin-activated ATPase and motility.

    Evidence Recombinant co-production and purification with in vitro ATPase and motility assays

    PMID:38606007

    Open questions at the time
    • MYL6 role ancillary to Myo5c characterization
    • Physiological context of MYL6–Myo5c pairing not addressed
  12. 2025 Medium

    Identified a glomerular-hypertension-responsive Myl6 isoform switch that alters the C-terminal sequence and predicted interaction properties, linking mechanical stress to myosin remodeling.

    Evidence RNA-Seq splicing analysis, proteomics, RT-PCR, and in situ hybridization in mechanically stretched murine podocytes

    PMID:40418580

    Open questions at the time
    • Functional consequence of the C-terminal switch predicted, not measured
    • Whether the switch changes contractility unknown
  13. 2025 Medium

    Uncovered a non-myosin function for MYL6 as a pseudouridine-binding protein that directs modified RNAs into extracellular vesicles.

    Evidence Genome-wide CRISPR screen, proteomics, and pseudouridine-RNA binding assays (preprint)

    PMID:41280092

    Open questions at the time
    • Preprint not yet peer-reviewed
    • How a myosin light chain reads RNA modifications structurally unexplained
  14. 2026 High

    Defined a signaling role for MYL6 in innate immunity: STIM1/Ca2+-activated MYL6 engages phospho-Tyr242 cGAS to drive cGAS condensation and type I interferon responses in lung endothelium.

    Evidence Phosphomimetic/phospho-dead cGAS mutants, co-IP, condensation imaging, Ca2+ measurement, STIM1 perturbation, and in vivo endothelium-specific cGAS rescue in lung infection

    PMID:42154837

    Open questions at the time
    • Whether MYL6's myosin/actin activity is required for cGAS condensation unresolved
    • Direct vs scaffolded contact with cGAS not structurally defined
  15. 2026 Low

    Linked MYL6 to myoblast differentiation through interaction with a circRNA-encoded micropeptide that upregulates MYL6 and accelerates muscle regeneration.

    Evidence Co-IP of ARHGAP10-202aa with MYL6 and in vivo muscle regeneration overexpression model

    PMID:41617081

    Open questions at the time
    • Single Co-IP; MYL6 a secondary partner
    • Causal role of MYL6 in the differentiation phenotype not isolated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single essential myosin light chain coordinates its canonical structural role with emerging non-cytoskeletal activities (RNA modification reading, cGAS-coupled signaling, integrin avidity control) remains unresolved.
  • No structural model distinguishing myosin-bound vs free MYL6 functional states
  • Mechanism by which isoform/splice variants partition among these roles unknown
  • Whether non-myosin functions require myosin binding untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0005198 structural molecule activity 2 GO:0003723 RNA binding 1
Localization
GO:0005856 cytoskeleton 2 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 2 R-HSA-109582 Hemostasis 1
Partners
CGASHSPA8KINDLIN-3MYH10MYH9MYL12AMYL12BSPATA6
Complex memberships
Myosin 5c holoenzymenon-muscle myosin IIA

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 MYL6 (ELC) is a component of non-muscle myosin II complexes, associating with myosin heavy chains MYH9 (NMHC IIA) and MYH10 (NMHC IIB) as well as regulatory light chains MYL12A, MYL12B, and MYL9 in NIH 3T3 fibroblasts. Knockdown of regulatory light chains MYL12A/12B caused significant reduction in MYL6 protein levels, indicating that RLC expression is required to maintain MYL6 stability within the myosin II complex. Proteomic association analysis (Co-IP/MS), siRNA knockdown with Western blot quantification in NIH 3T3 fibroblasts The Biochemical journal Medium 21126233
1996 MYL6 (MLC3nm, the nonmuscle essential light chain isoform) shows the lowest sarcomeric sorting specificity among alkali MLC isoforms when expressed in cardiomyocytes; it distributes throughout the cytoplasm rather than localizing to A-bands. The N-terminal lobe of each MLC isoprotein is responsible for isoform-specific sarcomeric sorting. Double epitope-tagging competition assay with confocal microscopy in adult and neonatal rat ventricular cardiomyocytes; chimeric cDNA expression Journal of cell science Medium 8856505
1990 Human MYL6 encodes two closely related essential light chain isoforms (MLC1sa and MLC3nm) generated from the same gene via alternative splicing; in smooth muscle one exon is spliced out of the MLC3nm transcript to give an alternative product. MLC3nm is the major nonmuscle alkaline myosin light chain across multiple species. MLC1sa expression is detected at the onset of myogenesis and is present in nonmuscle cells. cDNA cloning and sequencing, isoform-specific probes, RNA expression analysis in multiple species and cell types, RT-PCR validation Molecular and cellular biology Medium 2304459
2015 SPATA6, a testis-specific protein required for sperm head-tail coupling apparatus (HTCA) assembly, interacts with myosin subunit MYL6, implicating MYL6 in myosin-based microfilament transport during spermiogenesis. Proteomic analysis of SPATA6-interacting proteins in mouse spermatids Proceedings of the National Academy of Sciences of the United States of America Low 25605924
2024 BAG5, a co-chaperone expressed in step 9-16 spermatids, is required for proper folding of MYL6 (along with MYO5A and dynein subunits) during sperm HTCA assembly. In BAG5-deficient mice, MYL6 and other cargo transport-related myosin proteins are misfolded, leading to acephalic spermatozoa syndrome. BAG5 promotes folding by forming a complex with HSPA8 and enhancing HSPA8's affinity for substrate proteins including MYL6. BAG5 knockout mouse model, in vivo and in vitro protein folding assays, co-immunoprecipitation, Western blot EMBO reports Medium 38454159
2024 MYL6 interacts directly with kindlin-3 in platelets and is required for integrin αIIbβ3 activation, platelet aggregation, and proplatelet formation. Conditional knockout of Myl6 in the megakaryocyte lineage (Myl6fl/fl PF4-Cre mice) causes macrothrombocytopenia from defective proplatelet formation, suppresses integrin αIIbβ3 activation, and impairs hemostasis and thrombosis. MYL6 deficiency preferentially affected multivalent ligand binding to integrin αIIbβ3, suggesting MYL6 contributes to avidity modulation via kindlin-3. Conditional knockout mouse (Myl6fl/fl PF4-Cre), integrin activation assays, platelet aggregation assays, co-immunoprecipitation (kindlin-3 binding), hemostasis and thrombosis in vivo models Journal of thrombosis and haemostasis : JTH High 38266679
2022 Anti-MYL6 antibody found in a subset of microscopic polyangiitis patients disrupts G-actin polymerization into F-actin, thereby suppressing phorbol 12-myristate 13-acetate-induced neutrophil extracellular trap (NET) formation. This indicates that MYL6 is required for actin rearrangement necessary for NET formation in neutrophils. Fluorescent staining of actin polymerization and NET formation in neutrophils treated with anti-MYL6 antibody; ELISA for serum anti-MYL6 antibody; clinical correlation study Arthritis research & therapy Medium 36527167
2022 ADCK2 overexpression in melanoma cells reduces cell migration, and this effect is abrogated by knockdown of MYL6, establishing a functional connection between ADCK2 and MYL6 in the regulation of melanoma cell motility. MYL6 acts downstream of ADCK2 to modulate cell migration. siRNA-mediated knockdown and stable overexpression of ADCK2; scratch assay; transwell invasion assay; MYL6 knockdown in ADCK2-overexpressing cells; gene expression array Cancers Medium 35205819
2021 The lncRNA MAFG-AS1 physically interacts with three subunits of non-muscle myosin IIA — MYH9, MYL12B, and MYL6. Knockdown of MAFG-AS1 inhibits ATPase activity of MYH9 and disrupts interaction of NM IIA subunits, indicating that MYL6 participates in the functional non-muscle myosin IIA complex whose activity is modulated by MAFG-AS1. RNA immunoprecipitation (RIP)/pulldown identifying MYL6 as an MAFG-AS1-interacting protein; ATPase activity assay after MAFG-AS1 knockdown; co-IP of NM IIA subunits FASEB journal Low 33813778
2009 MYL6 was identified as a candidate interaction partner of PCBP1 (an hnRNP RNA-binding protein) by yeast two-hybrid screening, pulldown in yeast, co-immunoprecipitation, and immunofluorescence assays. Yeast two-hybrid, yeast pulldown, co-immunoprecipitation, immunofluorescence microscopy Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences Low 19727228
2024 Myo5c (Myosin 5c) can be co-produced with MYL6 (essential light chain) and MYL12b (regulatory light chain) as well as calmodulin. Purified Myo5c-HMM produced with CaM plus MYL6/MYL12b retains actin-activated ATPase and motile activity, demonstrating that MYL6 can function as a light chain for Myosin 5c. Recombinant protein co-production and purification; in vitro actin-activated ATPase assay; motility assay Frontiers in physiology Medium 38606007
2026 Phosphorylation of Tyr242 on cGAS facilitates its interaction with activated MYL6 in lung endothelial cells, enabling cGAS condensation and activation, leading to IFNB mRNA expression. Intracellular Ca2+ increase upon cGAS binding to dsDNA requires the ER Ca2+ sensor STIM1 to activate MYL6 for cGAS condensation. Expression of wild-type or phosphomimetic cGAS in cGAS-deficient mouse lung endothelium enhanced innate immune signaling and lung damage after Pseudomonas aeruginosa infection. Phosphomimetic/phospho-dead cGAS mutants, co-immunoprecipitation, cGAS condensation imaging, Ca2+ measurement, STIM1 perturbation, in vivo lung infection model with endothelium-specific cGAS rescue Science signaling High 42154837
2025 MYL6 is a pseudouridine-binding protein required for secretion of RNAs into extracellular vesicles. Genome-wide CRISPR screening and proteomics identified MYL6 as necessary for extracellular RNA export; pseudouridine modification of RNA is both necessary and sufficient for this export, and MYL6 reads this modification to direct RNA into extracellular routes. Genome-wide CRISPR screen, proteomics, high-sensitivity transcriptomics, pseudouridine-RNA binding assays, extracellular vesicle RNA profiling bioRxivpreprint Medium 41280092
2026 ARHGAP10-202aa, a protein encoded by the circRNA circARHGAP10, interacts with MYL6 and promotes myoblast differentiation. In vivo overexpression of ARHGAP10-202aa significantly enhances MYL6 expression and accelerates regeneration of injured tibialis anterior muscle in mice. Co-immunoprecipitation (ARHGAP10-202aa – MYL6 interaction), functional differentiation assays, in vivo muscle regeneration model with overexpression Journal of genetics and genomics Low 41617081
2025 Under mechanical stretch simulating glomerular hypertension, murine podocytes undergo an isoform switch of Myl6 mRNAs accompanied by an alteration in the C-terminal amino acid sequence of the encoded protein, which is predicted to alter Myl6 interaction properties within the myosin complex. RNA-Seq with multiple splicing analysis tools, proteomics, quantitative RT-PCR, in situ hybridization in mechanically stretched murine podocytes Journal of the American Society of Nephrology : JASN Medium 40418580

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2019 Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. The Journal of allergy and clinical immunology 280 31669095
2015 Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Proceedings of the National Academy of Sciences of the United States of America 152 25605924
2023 Pan-cancer genetic analysis of disulfidptosis-related gene set. Cancer genetics 127 37879141
2011 Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity. The Biochemical journal 106 21126233
2015 Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes. PloS one 96 25978043
2006 Cell type and culture condition-dependent alternative splicing in human breast cancer cells revealed by splicing-sensitive microarrays. Cancer research 72 16488998
1990 Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. Molecular and cellular biology 56 2304459
2021 RNA splicing programs define tissue compartments and cell types at single-cell resolution. eLife 54 34515025
2007 Identification and expression analysis of genes associated with bovine blastocyst formation. BMC developmental biology 48 17559642
2020 The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles. Cancers 42 32512867
2023 Identification of disulfidptosis-related genes and subgroups in Alzheimer's disease. Frontiers in aging neuroscience 36 37600517
2020 Identification of novel mRNA isoforms associated with meat tenderness using RNA sequencing data in beef cattle. Meat science 27 33248741
1996 The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition. Journal of cell science 27 8856505
2022 FAM83A is a potential biomarker for breast cancer initiation. Biomarker research 25 35183258
2021 HBx-upregulated MAFG-AS1 promotes cell proliferation and migration of hepatoma cells by enhancing MAFG expression and stabilizing nonmuscle myosin IIA. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25 33813778
2015 Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D. Chinese journal of natural medicines 18 26412427
2022 ADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6. Cancers 17 35205819
2024 BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly. EMBO reports 15 38454159
2024 Unveiling the role of disulfidptosis-related genes in the pathogenesis of non-alcoholic fatty liver disease. Frontiers in immunology 15 38812509
2018 A Novel 12q13.2-q13.3 Microdeletion Syndrome With Combined Features of Diamond Blackfan Anemia, Pierre Robin Sequence and Klippel Feil Deformity. Frontiers in genetics 14 30524470
2020 DNA Methylation Reorganization of Skeletal Muscle-Specific Genes in Response to Gestational Obesity. Frontiers in physiology 13 32848869
2003 Myosin light chain genes in the turkey (Meleagris gallopavo). Cytogenetic and genome research 13 14970726
1998 Characterisation of a bovine/murine hybrid cell panel informative for all bovine autosomes. Animal genetics 11 9745669
2022 Transcriptome analyses of potential regulators of pre- and post-ovulatory follicles in the pigeon (Columba livia). Reproduction, fertility, and development 10 35366957
2007 Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice. International journal of oncology 10 17611698
2021 miRNAs and Their Gene Targets-A Clue to Differentiate Pregnancies with Small for Gestational Age Newborns, Intrauterine Growth Restriction, and Preeclampsia. Diagnostics (Basel, Switzerland) 8 33923995
2024 Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2. International journal of molecular sciences 7 38674105
2024 Identification and verification of disulfidptosis-related genes in sepsis-induced acute lung injury. Frontiers in medicine 7 39262873
2022 Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation. Arthritis research & therapy 7 36527167
2018 Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish (Carassius auratus) to Alter Fast Muscle Contractile Properties With Seasonal Temperature Change. Frontiers in physiology 7 30568597
2023 A comprehensive landscape of transcription profiles and data resources for human leukemia. Blood advances 6 36595475
2021 RBBP4 Enhances Platinum Chemo Resistance in Lung Adenocarcinoma. BioMed research international 6 33506032
2009 Identification of novel partner proteins of PCBP1. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 6 19727228
2024 Myosin light chain 6 (Myl6) interacts with kindlin-3 and is required to support integrin αIIbβ3 activation in platelets in mice. Journal of thrombosis and haemostasis : JTH 5 38266679
2024 Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis. Open medicine (Warsaw, Poland) 5 38584831
2024 Disulfidptosis: A New Target for Parkinson's Disease and Cancer. Current issues in molecular biology 5 39329952
2012 Novel transcripts and alternatively spliced genes are associated with early development in bovine embryos. Animal : an international journal of animal bioscience 5 23031207
2025 Alternative Splicing in Mechanically Stretched Podocytes as a Model of Glomerular Hypertension. Journal of the American Society of Nephrology : JASN 4 40418580
2024 Evaluation of a proteomic signature coupled with the kidney failure risk equation in predicting end stage kidney disease in a chronic kidney disease cohort. Clinical proteomics 4 38762513
2024 Novel insights of disulfidptosis-mediated immune microenvironment regulation in atherosclerosis based on bioinformatics analyses. Scientific reports 4 39521794
2025 A Novel Disulfidptosis-Related Diagnostic Gene Signature and Differential Expression Validation in Ischaemic Cardiomyopathy. Journal of cellular and molecular medicine 3 40070032
2024 Motor properties of Myosin 5c are modulated by tropomyosin isoforms and inhibited by pentabromopseudilin. Frontiers in physiology 3 38606007
2024 Characterization and proteomic analysis of plasma-derived small extracellular vesicles in locally advanced rectal cancer patients. Cellular oncology (Dordrecht, Netherlands) 3 39162991
2023 Analysis of RNA processing directly from spatial transcriptomics data reveals previously unknown regulation. bioRxiv : the preprint server for biology 3 36993757
2021 Proteomic and electron microscopy study of myogenic differentiation of alveolar mucosa multipotent mesenchymal stromal cells in three-dimensional culture. Proteomics 2 34674377
2026 Shared splicing dysregulation in heart failure associated with dilated and ischaemic cardiomyopathy and spatial specificity across cardiac regions. Cardiovascular research 1 41877661
2025 Identification of disulfidptosis-related genes and subgroups in spinal cord injury. Spinal cord 1 40319145
2025 Identification of disulfidptosis-related genes in immunity and immunotherapy in diabetic foot ulcer. Annals of medicine and surgery (2012) 1 41675755
2026 Circulating Extracellular Vesicle Protein Biomarkers for the Early Detection of High-Grade Serous Ovarian Cancer. Molecular & cellular proteomics : MCP 0 41519436
2026 The ARHGAP10-202aa protein encoded by circARHGAP10 promotes skeletal muscle development and regeneration. Journal of genetics and genomics = Yi chuan xue bao 0 41617081
2026 Single-cell sequencing combined with transcriptome sequencing to reveal the molecular mechanisms related to integrated stress responses in atherosclerosis. Journal of cardiothoracic surgery 0 41840716
2026 Pre-infusion plasma proteomics identifies an endothelial-immune priming signature predictive of severe cytokine release syndrome and neurotoxicity following CAR T-cell therapy in relapsed/refractory lymphoma. medRxiv : the preprint server for health sciences 0 41959837
2026 Condensation of cGAS induced by Tyr242 phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung. Science signaling 0 42154837
2025 Sepsis Important Genes Identification Through Biologically Informed Deep Learning and Transcriptomic Analysis. Clinical and experimental pharmacology & physiology 0 40356040
2025 Investigating the role of disulfidoptosis in spinal cord injury and development of a novel diagnostic model. Acta orthopaedica et traumatologica turcica 0 40726387
2025 Pseudouridine selects RNAs for extracellular transport. bioRxiv : the preprint server for biology 0 41280092

Missed literature

Know a paper Affinage missed for MYL6? Flag it for the maintainers and the community.

No submissions yet.